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1. A hybrid metal-organic framework nanomedicine-mediated photodynamic therapy and hypoxia-activated cancer chemotherapy

Author:
Zhen Jia; Yong Gao; Jiali Ni; Xiaochang Wu; Zhengwei Mao; Guoping Sheng; Yuefeng Zhu
Source:
Journal of colloid and interface science 2023 v.629 pp. 379-390
ISSN:
0021-9797
Subject:
hypoxia,   etc   ; antineoplastic agents; blood; blood circulation; coordination polymers; hybridization; immunotherapy; nanogold; nanomedicine; neoplasms; pharmacokinetics; phosphates; photochemotherapy; polyethylene glycol; porphyrins;     Show all 15 Subjects
Abstract:
... The hypoxic tumor microenvironment and photodynamic therapy (PDT)-aggravated hypoxia compromise the anticancer efficacy of chemotherapy, immunotherapy, and PDT. Thus, sophisticated nanomedicines that can activate their anticancer capability in situ in response to specific stimuli need to be developed. This study aimed to construct a hybrid nanomedicine that activated chemotherapy by inducing hypox ...
DOI:
10.1016/j.jcis.2022.09.061

2. Regulation of epithelial‐to‐mesenchymal transition in hypoxia by the HIF‐1α network

Author:
Hang‐Yu Wang; Xiao‐Peng Zhang; Wei Wang
Source:
FEBS letters 2022 v.596 no.3 pp. 338-349
ISSN:
0014-5793
Subject:
hypoxia,   etc   ; metastasis; models;     Show all 3 Subjects
Abstract:
... Epithelial‐to‐mesenchymal transition (EMT) plays a significant role in cancer metastasis. A series of models have focused on EMT regulation by TGF‐β network. However, how EMT is regulated under hypoxia is less understood. We developed a model of HIF‐1α network to explore the potential link between EMT and the network topology. Our results revealed that three positive feedback loops, composed of HI ...
DOI:
10.1002/1873-3468.14258

3. Marine sponges in the once and future ocean

Author:
Daniel B. Mills; Erik A. Sperling
Source:
Global change biology 2022 v.28 no.6 pp. 1953-1955
ISSN:
1354-1013
Subject:
hypoxia,   etc   ; animals; global change; oceans;     Show all 4 Subjects
Abstract:
... Animals originated under hypoxia—low‐oxygen conditions that are currently expanding throughout the global ocean. How marine sponges respond to hypoxia is both relevant to reconstructing early animal evolution and for forecasting the fate of modern marine ecosystems. In a new effort, multiple sponge species from two different oceans were found to tolerate hypoxia in the lab, revealing a more genera ...
DOI:
10.1111/gcb.16053

4. Recent Advances in Petroleum Microbiology

Author:
Bo-Zhong Mu; Tamara N. Nazina
Source:
Microorganisms 2022 v.10 no.9 pp. -
ISSN:
2076-2607
Subject:
hypoxia,   etc   ; microbiology; petroleum; salinity; temperature;     Show all 5 Subjects
Abstract:
... Petroleum reservoirs are unique deep-subsurface ecosystems that are generally characterized by such extreme conditions as high temperature, high pressure, high salinity, and anoxia [...] ...
DOI:
10.3390/microorganisms10091706

5. The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches

Author:
Esmaa Bouhamida; Giampaolo Morciano; Mariasole Perrone; Asrat E. Kahsay; Mario Della Sala; Mariusz R. Wieckowski; Francesco Fiorica; Paolo Pinton; Carlotta Giorgi; Simone Patergnani
Source:
Biology 2022 v.11 no.2 pp. -
ISSN:
2079-7737
Subject:
hypoxia; hypoxia-inducible factor 1,   etc   ; humans; inflammation; mitochondria; mortality; oxidative stress; oxygen; pathogenesis; reactive oxygen species; therapeutics;     Show all 11 Subjects
Abstract:
... Cardiovascular diseases (CVDs) and cancer continue to be the primary cause of mortality worldwide and their pathomechanisms are a complex and multifactorial process. Insufficient oxygen availability (hypoxia) plays critical roles in the pathogenesis of both CVDs and cancer diseases, and hypoxia-inducible factor 1 (HIF-1), the main sensor of hypoxia, acts as a central regulator of multiple target g ...
DOI:
10.3390/biology11020300

6. Fluorescent probes for biomolecule detection under environmental stress

Author:
Xiaoyue Han; Yue Wang; Yan Huang; Xiaoyan Wang; Jaebum Choo; Lingxin Chen
Source:
Journal of hazardous materials 2022 v.431 pp. 128527
ISSN:
0304-3894
Subject:
hypoxia,   etc   ; fever; fluorescence; glucose; hypothermia; toxicity;     Show all 6 Subjects
Abstract:
... The use of fluorescent probes in visible detection has been developed over the last several decades. Biomolecules are essential in the biological processes of organisms, and their distribution and concentration are largely influenced by environmental factors. Significant advances have occurred in the applications of fluorescent probes for the detection of the dynamic localization and quantity of b ...
DOI:
10.1016/j.jhazmat.2022.128527

7. Oxygen-generating materials and their biomedical applications: a review

Author:
Xin Sun; Fanglian Yao; Hong Zhang; Junjie Li
Source:
Journal of materials science 2022 v.57 no.20 pp. 9077-9103
ISSN:
0022-2461
Subject:
hypoxia,   etc   ; metabolism; oxygen; reactive oxygen species;     Show all 4 Subjects
Abstract:
... Oxygen and reactive oxygen species (ROS), as indispensable small molecular substances in the basic metabolism of life, have become the key to the success of implantable medical materials, and their importance cannot be overstated. Either improving the hypoxia environment in vivo to avoid tissue damage or using the ROS to selectively kill cells are the strategies adopted in the actual biomedical ap ...
DOI:
10.1007/s10853-022-07229-1

8. HIF-1alpha/VEGF pathway mediates 1,3,6,8-tetrabromo-9 H-carbazole-induced angiogenesis: a potential vascular toxicity of an emerging contaminant

Author:
Tong Xu; Xiaoxu Hu; Guanglei Yang; Yiyun Liu; Qian Zhang; Shuyuan Yu; Guomin Chen; Yunping Li; Rui Sha; Yangsheng Chen; Heidi Qunhui Xie; Tai L. Guo; Li Xu; Bin Zhao
Source:
Journal of hazardous materials 2022 v.432 pp. 128718
ISSN:
0304-3894
Subject:
hypoxia; hypoxia-inducible factor 1,   etc   ; angiogenesis; aryl hydrocarbon receptors; carbazoles; computer simulation; erythropoietin; humans; luciferase; risk assessment; secretion; toxicity;     Show all 12 Subjects
Abstract:
... The dioxin-like substances polyhalogenated carbazoles (PHCZs) may trigger the aryl hydrocarbon receptor (AhR) signaling pathway. Although the crosstalk between AhR and the hypoxia inducible factor-1 (HIF-1) pathways is generally believed to occur, the exact mechanisms of the HIF-1 pathway in PHCZ toxicity have not been determined. We aimed to elucidate the effect of PHCZs on the HIF-1 pathway and ...
DOI:
10.1016/j.jhazmat.2022.128718

9. Nutrition and Immunity in Perinatal Hypoxic-Ischemic Injury

Author:
Hema Gandecha; Avineet Kaur; Ranveer Sanghera; Joanna Preece; Thillagavathie Pillay
Source:
Nutrients 2022 v.14 no.13 pp. -
ISSN:
2072-6643
Subject:
hypoxia,   etc   ; fetus; immune response; ischemia; neonates; nutrition;     Show all 6 Subjects
Abstract:
... Perinatal hypoxia ischaemia (PHI), acute and chronic, may be associated with considerable adverse outcomes in the foetus and neonate. The molecular and cellular mechanisms of injury and repair associated with PHI in the perinate are not completely understood. Increasing evidence is mounting for the role of nutrients and bioactive food components in immune development, function and repair in PHI. I ...
DOI:
10.3390/nu14132747

10. Rational design of a meso phosphate-substituted pyronin as a type I photosensitizer for photodynamic therapy

Author:
Yong Wang; Jigai Li; Yukun Zhang; Yi Nan; Xin Zhou
Source:
Chemical communications 2022 v.58 no.56 pp. 7797-7800
ISSN:
1364-548X
Subject:
hypoxia,   etc   ; oxygen consumption; photochemotherapy; photosensitizing agents; toxicity;     Show all 5 Subjects
Abstract:
... Type I photodynamic therapy (PDT) with less oxygen consumption shows great potential to overcome the malignant hypoxia in solid tumors. Herein, a novel meso phosphate-substituted pyronin PY-P and its nanoparticles (PY-P NPs) were prepared as an efficient type I organic photosensitizer. The in vivo data prove that PY-P NPs have outstanding low dark toxicity but high photocytotoxicity under hypoxia ...
DOI:
10.1039/d2cc02124b

11. In Situ Hypoxia-Induced Supramolecular Perylene Diimide Radical Anions in Tumors for Photothermal Therapy with Improved Specificity

Author:
Hua Wang; Ke-Fei Xue; Yuchong Yang; Hao Hu; Jiang-Fei Xu; Xi Zhang
Source:
Journal of the American Chemical Society 2022 v.144 no.5 pp. 2360-2367
ISSN:
1520-5126
Subject:
hypoxia,   etc   ; absorption; drug resistance; metastasis; neoplasms; photothermotherapy;     Show all 6 Subjects
Abstract:
... Considering that hypoxia is closely associated with tumor proliferation, invasion, metastasis, and drug resistance, it is of great significance to overcome hypoxia in tumor treatment. Herein, we report a hypoxia-induced specific photothermal therapy (PTT) based on the photothermal agent of supramolecular perylene diimide radical anions. Hypoxic regions in various tumors display strong reductive ab ...
DOI:
10.1021/jacs.1c13067

12. O-carboxymethyl chitosan based pH/hypoxia-responsive micelles relieve hypoxia and induce ROS in tumor microenvironment

Author:
Liqun Jiang; Mi Zhang; Yuting Bai; Feiyan Cui; Cong Zhang; Ziyao Wang; Sujia Si; Ling Yang; Yun Wang; Yudong Zhang; Lei Li; Shuo Liu; Xiangrong Wei; Yan Wang; Ya Xu; Jian Meng
Source:
Carbohydrate polymers 2022 v.275 pp. 118611
ISSN:
0144-8617
Subject:
hypoxia,   etc   ; chitosan; cytotoxicity; immunosuppression; micelles; neoplasms; oxygen;     Show all 7 Subjects
Abstract:
... The hypoxia in tumor microenvironment (TME) can upregulate the HIF-1α and PD-L1 expression and cause immunosuppression of tumor. In this study, a carboxymethyl chitosan-based pH/hypoxia-responsive and γ-Fe₂O₃/isosorbide dinitrate carrying micelle was designed, and it could catalyze endogenous H₂O₂ to generate oxygen and relieve hypoxia in TME, so as to relieve the overexpression of HIF-1α and PD-L ...
DOI:
10.1016/j.carbpol.2021.118611

13. Two birds with one stone: innovative ceria-loaded gold@platinum nanospheres for photothermal-catalytic therapy of tumors

Author:
Minglu Tang; Zhaocong Zhang; Chengwen Ding; Jingqi Li; Yangtian Shi; Tiedong Sun; Chunxia Chen
Source:
Journal of colloid and interface science 2022 v.627 pp. 299-307
ISSN:
0021-9797
Subject:
hypoxia,   etc   ; metastasis; nanospheres; neoplasms; photothermotherapy; polyethylene glycol; toxicity;     Show all 7 Subjects
Abstract:
... Photothermal therapy (PTT) has been widely employed in tumor treatment due to the non-invasive, highly selective, and low toxic side effects. However, the limited penetration of laser couples with the metastasis and recurrence of tumors, thus failing to eliminate them. Here, we report that ceria-loaded gold@platinum (CeO₂/Au@Pt) nanospheres modified with polyethylene glycol (PEG). exhibit dual enz ...
DOI:
10.1016/j.jcis.2022.07.065

14. Anti-angiogenic nano-delivery system promotes tumor vascular normalizing and micro-environment reprogramming in solid tumor

Author:
Ruoyu Shen; Lijun Peng; Wentao Zhou; Ding Wang; Qi Jiang; Jian Ji; Fuqiang Hu; Hong Yuan
Source:
Journal of controlled release 2022 v.349 pp. 550-564
ISSN:
0168-3659
Subject:
hypoxia,   etc   ; breast neoplasms; drugs; models; neoplasm progression; therapeutics;     Show all 6 Subjects
Abstract:
... Aberrant tumor vasculature leads to the malignant tumor microenvironment (TME) for tumor progression. Research has found temporary tumor vascular normalization after treated with low-dose anti-angiogenic agents, however, has paid little attention to prolonging the normalization window and its further influence on tumor tissue. Based on the dose- and time-dependent effect of anti-angiogenic agents, ...
DOI:
10.1016/j.jconrel.2022.07.015

15. Widespread oxyregulation in tropical corals under hypoxia

Author:
David J. Hughes; James Alexander; Gary Cobbs; Michael Kühl; Chris Cooney; Mathieu Pernice; Deepa Varkey; Christian R. Voolstra; David J. Suggett
Source:
Marine pollution bulletin 2022 v.179 pp. 113722
ISSN:
0025-326X
Subject:
hypoxia,   etc   ; air; corals; marine pollution; oxygen; partial pressure;     Show all 6 Subjects
Abstract:
... Hypoxia (low oxygen stress) is increasingly reported on coral reefs, caused by ocean deoxygenation linked to coastal nutrient pollution and ocean warming. While the ability to regulate respiration is a key driver of hypoxia tolerance in many other aquatic taxa, corals' oxyregulatory capabilities remain virtually unexplored. Here, we examine O₂-consumption patterns across 17 coral species under dec ...
DOI:
10.1016/j.marpolbul.2022.113722

16. Oxygen sensors mediated HIF-1α accumulation and translocation: A pivotal mechanism of fine particles-exacerbated myocardial hypoxia injury

Author:
Ze Zhang; Liu Wu; Tenglong Cui; Rifat Zubair Ahmed; Haiyi Yu; Rong Zhang; Yanhong Wei; Daochuan Li; Yuxin Zheng; Wen Chen; Xiaoting Jin
Source:
Environmental pollution 2022 v.300 pp. 118937
ISSN:
0269-7491
Subject:
hypoxia; hypoxia-inducible factor 1,   etc   ; chronic exposure; energy metabolism; glycolysis; hypertrophy; models; mortality; myocardial ischemia; myocardium; oxygen; particulates; pollution; procollagen-proline dioxygenase; proteinases; ubiquitin;     Show all 16 Subjects
Abstract:
... Epidemiological studies have demonstrated a strong association of ambient fine particulate matter (PM₂.₅) exposure with the increasing mortality by ischemic heart disease (IHD), but the involved mechanisms remain poorly understood. Herein, we found that the chronic exposure of real ambient PM₂.₅ led to the upregulation of hypoxia-inducible factor-1 alpha (HIF-1α) protein in the myocardium of mice, ...
DOI:
10.1016/j.envpol.2022.118937

17. Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders

Author:
Claudia J. Diehl; Alessio Ciulli
Source:
Chemical Society reviews 2022 v.51 no.19 pp. 8216-8257
ISSN:
1460-4744
Subject:
hypoxia,   etc   ; ligands; protein degradation; proteolysis; ubiquitin-protein ligase; ubiquitination;     Show all 6 Subjects
Abstract:
... The von Hippel-Lindau (VHL) Cullin RING E3 ligase is an essential enzyme in the ubiquitin-proteasome system that recruits substrates such as the hypoxia inducible factor for ubiquitination and subsequent proteasomal degradation. The ubiquitin-proteasome pathway can be hijacked toward non-native neo-substrate proteins using proteolysis targeting chimeras (PROTACs), bifunctional molecules designed t ...
DOI:
10.1039/d2cs00387b

18. Efficiency of pre‐process anoxia treatment on quality of fresh‐cut pineapples cv. ‘Phulae’ during storage

Author:
Suriyan Supapvanich; Chairat Techavuthiporn
Source:
International journal of food science & technology 2022 v.57 no.3 pp. 1679-1687
ISSN:
0950-5423
Subject:
hypoxia,   etc   ; ascorbic acid; food science; pineapples; weight loss; yeasts;     Show all 6 Subjects
Abstract:
... The aim of this study was to investigate the competency of pre‐process anoxia treatment on physicochemical quality of fresh‐cut pineapples cv. ‘Phulae’ during storage. The fruits were kept in anoxia atmosphere (N₂) for 16 h before processing. The fruits were processed immediately after treatment (G1) and after storage at 13 °C for 6 days (G2). Anoxia treatment delayed the weight loss and had no ef ...
DOI:
10.1111/ijfs.15533

19. Noncovalent Dual-Locked Near-Infrared Fluorescent Probe for Precise Imaging of Tumor via Hypoxia/Glutathione Activation

Author:
Xiao-Bo Zhao; Jing-Yan Kang; Yan-Ping Shi
Source:
Analytical chemistry 2022 v.94 no.17 pp. 6574-6581
ISSN:
1520-6882
Subject:
hypoxia,   etc   ; analytical chemistry; fluorescence; fluorescent dyes; glutathione; neoplasms; patients;     Show all 7 Subjects
Abstract:
... Stimulus-responsive fluorescent probes have broad applications in the early detection and treatment of tumors and thus promote the personalized treatment of tumors and improve patient survival. Among the repertoires of probes, dual-locked near-infrared (NIR) fluorescent probes are of great significance due to their improved specificity and multiplex detection in tumor imaging but remain to be expl ...
DOI:
10.1021/acs.analchem.2c00406

20. Oxygen Vacancy-Mediated CuCoFe/Tartrate-LDH Catalyst Directly Activates Oxygen to Produce Superoxide Radicals: Transformation of Active Species and Implication for Nitrobenzene Degradation

Author:
Shaohong Wang; Jiayi Zhu; Ting Li; Fei Ge; Zhihao Zhang; Runliang Zhu; Haijiao Xie; Yin Xu
Source:
Environmental science & technology 2022 v.56 no.12 pp. 7924-7934
ISSN:
1520-5851
Subject:
hypoxia,   etc   ; catalysts; catalytic activity; energy; nitrobenzenes; oxygen; wastewater treatment;     Show all 7 Subjects
Abstract:
... Oxygen vacancies play a vital role in the catalytic activity of layered double hydroxide (LDH) catalysts in wastewater treatment. However, the mechanism of oxygen vacancy-mediated LDH-activated oxygen to produce reactive oxygen species (ROS) still lacks a reasonable explanation. In this work, a tartrate-modified CuCoFe-LDH (CuCoFe/Tar-LDH) with abundant oxygen vacancies was designed, which can eff ...
DOI:
10.1021/acs.est.2c00522