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1. The effect of maternal antibodies on the cellular immune response after infant vaccination: A review

Author:
Orije, Marjolein R.P.; Maertens, Kirsten; Corbière, Véronique; Wanlapakorn, Nasamon; Van Damme, Pierre; Leuridan, Elke; Mascart, Françoise
Source:
Vaccine 2020 v.38 no.1 pp. 20-28
ISSN:
0264-410X
Subject:
cell-mediated immunity; humoral immunity; maternal immunity,   etc   ; antibodies; humans; infants; infectious diseases; labor; laboratory techniques; live vaccines; vaccination;     Show all 11 Subjects
Abstract:
... During the last few decades, maternal immunization as a strategy to protect young infants from infectious diseases has been increasingly recommended, yet some issues have emerged. Studies have shown that for several vaccines, such as live attenuated, toxoid and conjugated vaccines, high maternal antibody titers inhibit the infant’s humoral immune response after infant vaccination. However, it is n ...
DOI:
10.1016/j.vaccine.2019.10.025

2. Synthetic 3D scaffolds for cancer immunotherapy

Author:
Kurum, Armand; Gao, Min; Tang, Li
Source:
Current opinion in biotechnology 2020 v.65 pp. 1-8
ISSN:
0958-1669
Subject:
immunity,   etc   ; adverse effects; clinical trials; immunotherapy; neoplasms;     Show all 5 Subjects
Abstract:
... Recent clinical success of systemic cancer immunotherapy has paved the way for the next-generation therapeutics. Nevertheless, cancer immunotherapies, in particular combination therapies, are associated in some cases with severe side effects and low response rates. Synthetic scaffolds have emerged as a promising platform to deliver immunotherapeutic agents locally. Placed at strategic locations of ...
DOI:
10.1016/j.copbio.2019.11.010

3. A More Granular View of Neutrophils in Malaria

Author:
Amulic, Borko; Moxon, Christopher A.; Cunnington, Aubrey J.
Source:
Trends in parasitology 2020 v.36 no.6 pp. 501-503
ISSN:
1471-4922
Subject:
immunity,   etc   ; Plasmodium; inflammation; malaria; neutrophils; pathogenesis;     Show all 6 Subjects
Abstract:
... Neutrophils are abundant innate immune cells with crucial roles in immunity and vascular inflammation. Recent evidence indicates that neutrophils have a dual role in malaria, contributing to both pathogenesis and control of Plasmodium. We discuss emerging mechanisms behind these opposing functions and identify key outstanding questions. ...
DOI:
10.1016/j.pt.2020.03.003

4. Japanese encephalitis in the Western Pacific Region: Implication from the Republic of Korea

Author:
Choe, Young June; Jee, Youngmee; Takashima, Yoshihiro; Lee, Jong-koo
Source:
Vaccine 2020 v.38 no.13 pp. 2760-2763
ISSN:
0264-410X
Subject:
immunity,   etc   ; encephalitis; monitoring; vaccination; vaccines; South Korea;     Show all 6 Subjects
Abstract:
... Japanese encephalitis (JE) is endemic in the Western Pacific Region. We aim to describe the regional status of control of JE, based on the World Health Organization (WHO) surveillance data, and to share the experience from the Republic of Korea. Substantial progress has been made in the region to date; however, epidemiologic changes have not been delineated. The vaccination coverage should be addr ...
DOI:
10.1016/j.vaccine.2020.02.061

5. Pertussis vaccines: The first hundred years

Author:
Guiso, Nicole; Meade, Bruce D.; Wirsing von König, Carl Heinz
Source:
Vaccine 2020 v.38 no.5 pp. 1271-1276
ISSN:
0264-410X
Subject:
immunity,   etc   ; children; infants; morbidity; mortality; vaccines;     Show all 6 Subjects
Abstract:
... Vaccines against pertussis have been used for more than a hundred years. This review describes the development of whole-cell (wP) and acellular pertussis (aP) vaccines, which, as DTP combination vaccines, have significantly reduced morbidity and mortality from pertussis, and which currently serve as the building blocks for a variety of vaccines used to immunize all infants worldwide. Two series of ...
DOI:
10.1016/j.vaccine.2019.11.022

6. Seeking the optimal schedule for chickenpox vaccination in Canada: Using an agent-based model to explore the impact of dose timing, coverage and waning of immunity on disease outcomes

Author:
Rafferty, Ellen R.S.; McDonald, Wade; Osgood, Nathaniel D.; Qian, Weicheng; Doroshenko, Alexander
Source:
Vaccine 2020 v.38 no.3 pp. 521-529
ISSN:
0264-410X
Subject:
immunity,   etc   ; antigens; models; risk; vaccination; vaccines; Alberta;     Show all 7 Subjects
Abstract:
... Many countries continue to consider implementing a universal chickenpox vaccine program; however, there is no consensus on the most appropriate and effective timing between vaccine doses. The chickenpox vaccine schedule debate is highlighted in Canada, where there are currently eight different vaccine schedules across the country. The objective of this study was to test the overall effectiveness o ...
DOI:
10.1016/j.vaccine.2019.10.065

7. Plant and Animal Innate Immunity Complexes: Fighting Different Enemies with Similar Weapons

Author:
Mermigka, Glykeria; Amprazi, Maria; Mentzelopoulou, Adriani; Amartolou, Argyro; Sarris, Panagiotis F.
Source:
Trends in plant science 2020 v.25 no.1 pp. 80-91
ISSN:
1360-1385
Subject:
innate immunity,   etc   ; inflammasomes; mammals; plants (botany); receptors;     Show all 5 Subjects
Abstract:
... Both animals and plants express intracellular innate immunity receptors known as NLR (NOD-like receptors or nucleotide-binding domain and leucine-rich repeat receptors, respectively). For various mammalian systems, the specific formation of macromolecular structures, such as inflammasomes by activated NLR receptors, has been extensively reported. However, for plant organisms, the formation of such ...
DOI:
10.1016/j.tplants.2019.09.008

8. Hemocytin facilitates host immune responses against Nosema bombycis

Author:
Ni, Wenjia; Bao, Jialing; Mo, Biying; Liu, Lulu; Li, Tian; Pan, Guoqing; Chen, Jie; Zhou, Zeyang
Source:
Developmental and comparative immunology 2020 v.103 pp. 103495
ISSN:
0145-305X
Subject:
adaptive immunity; innate immunity,   etc   ; Nosema bombycis; RNA interference; agglutination; antimicrobial peptides; hemocytes; invertebrates; melanization; pathogens; silkworms;     Show all 11 Subjects
Abstract:
... Invertebrates lack an adaptive immune response and thus are reliant on their innate immune response for eliminating invading pathogens. The innate immune responses of silkworms against the pathogen Nosema bombycis include: hemocyte aggregation, melanization, antimicrobial peptides, etc. In our current study, we discovered that a silkworm hemostasis-related protein, hemocytin, is up-regulated after ...
DOI:
10.1016/j.dci.2019.103495

9. Pattern recognition receptors in annelids

Author:
Prochazkova, P.; Roubalova, R.; Dvorak, J.; Navarro Pacheco, N.I.; Bilej, M.
Source:
Developmental and comparative immunology 2020 v.102
ISSN:
0145-305X
Subject:
adaptive immunity; innate immunity,   etc   ; Annelida; antibodies; chemical structure; invertebrates; lymphocytes; microorganisms; pathogen-associated molecular patterns; receptors;     Show all 10 Subjects
Abstract:
... The existence of pattern recognition receptors (PRRs) on immune cells was discussed in 1989 by Charles Janeway, Jr., who proposed a general concept of the ability of PRRs to recognize and bind conserved molecular structures of microorganisms known as pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, PRRs trigger intracellular signaling cascades resulting in the expression of va ...
DOI:
10.1016/j.dci.2019.103493

10. Comparison of immunomodulatory effects of three polysaccharide fractions from Lentinula edodes water extracts

Author:
Chen, Shuping; Liu, Cencen; Huang, Xiaojun; Hu, Liuyun; Huang, Yansheng; Chen, Hongzhang; Fang, Qiuyue; Dong, Nan; Li, Mingzhi; Tang, Wei; Nie, Shaoping
Source:
Journal of functional foods 2020 v.66 pp. 103791
ISSN:
1756-4646
Subject:
cell-mediated immunity; humoral immunity; innate immunity,   etc   ; Lentinula edodes; cell proliferation; cytotoxicity; immunoglobulins; immunomodulators; immunosuppression; molecular weight; mushrooms; natural killer cells; polysaccharides; splenocytes;     Show all 14 Subjects
Abstract:
... Lentinula edodes (L. edodes) is a type of edible mushroom which is known to beneficially support the immune system. In this study, three polysaccharide fractions (F1, F2 and F3) were isolated from L. edodes water extracts. Their molecular weights distribution (F1 > F2 > F3) and their immunomodulatory properties were investigated. Thymus index, thickness of footpad, proliferation of splenocytes, im ...
DOI:
10.1016/j.jff.2020.103791

11. Bispecific antibodies in cancer immunotherapy

Author:
Rader, Christoph
Source:
Current opinion in biotechnology 2020 v.65 pp. 9-16
ISSN:
0958-1669
Subject:
innate immunity,   etc   ; T-lymphocytes; antibodies; antigens; immunotherapy; neoplasms; toxicity;     Show all 7 Subjects
Abstract:
... Among antibody-based cancer therapies, bispecific antibodies (biAbs) have gained momentum in preclinical and clinical investigations following the regulatory approvals of the trailblazing T-cell engaging biAb (T-biAb) blinatumomab. Discussed herein are recent strategies that aim at boosting the potency and mitigating the toxicity of T-biAbs, broadening their therapeutic utility from hematologic to ...
DOI:
10.1016/j.copbio.2019.11.020

12. Apoplastic effector proteins of plant-associated fungi and oomycetes

Author:
Rocafort, Mercedes; Fudal, Isabelle; Mesarich, Carl H
Source:
Current opinion in plant biology 2020 v.56 pp. 9-19
ISSN:
1369-5266
Subject:
immunity,   etc   ; Oomycetes; anti-infective agents; apoplast; fungi; immunologic receptors; neutralization;     Show all 7 Subjects
Abstract:
... The outcome of an interaction between a plant and a fungus or an oomycete, whether compatibility or incompatibility, is often determined in the hostile extracellular spaces and matrices of the apoplast. Indeed, for compatibility to occur, many plant-associated fungi and oomycetes must first neutralize the apoplast, which is both monitored by plant cell-surface immune receptors, and enriched in pla ...
DOI:
10.1016/j.pbi.2020.02.004

13. Multi-metal nutrient restriction and crosstalk in metallostasis systems in microbial pathogens

Author:
Jordan, Matthew R; Wang, Jiefei; Capdevila, Daiana A; Giedroc, David P
Source:
Current opinion in microbiology 2020 v.55 pp. 17-25
ISSN:
1369-5274
Subject:
immunity,   etc   ; bacteria; catalytic activity; enzymes; manganese; pathogens; proteins; zinc;     Show all 8 Subjects
Abstract:
... Transition metals from manganese to zinc function as catalytic and structural cofactors for an amazing diversity of proteins and enzymes, and thus are essential for all forms of life. During infection, inflammatory host proteins limit the accessibility of multiple transition metals to invading pathogens in a process termed nutritional immunity. In order to respond to host-mediated metal starvation ...
DOI:
10.1016/j.mib.2020.01.010

14. The unconventional role of HLA-E: The road less traveled

Author:
Grant, Emma J.; Nguyen, Andrea T.; Lobos, Christian A.; Szeto, Christopher; Chatzileontiadou, Demetra S.M.; Gras, Stephanie
Source:
Molecular immunology 2020 v.120 pp. 101-112
ISSN:
0161-5890
Subject:
adaptive immunity,   etc   ; T-lymphocytes; antigens; humans; monitoring; pathogens; peptides;     Show all 7 Subjects
Abstract:
... Histocompatibility Leukocyte Antigens, or HLAs, are one of the most polymorphic molecules in humans. This high degree of polymorphism endows HLA molecules with the ability to present a vast array of peptides, an essential trait for responding to ever-evolving pathogens. Unlike classical HLA molecules (HLA-Ia), some non-classical HLA-Ib molecules, including HLA-E, are almost monomorphic. Several st ...
DOI:
10.1016/j.molimm.2020.02.011

15. Immunostimulating effect of polysaccharides isolated from Ma-Nuo-Xi decoction in cyclophosphamide-immunosuppressed mice

Author:
Jie, Duo; Gao, Tingting; Shan, Zhongshu; Song, Jiayin; Zhang, Ming; Kurskaya, Olga; Sharshov, Kirill; Wei, Lixin; Bi, Hongtao
Source:
International journal of biological macromolecules 2020 v.146 pp. 45-52
ISSN:
0141-8130
Subject:
immunity,   etc   ; Oriental traditional medicine; arabinogalactans; cyclophosphamide; mice; pectins;     Show all 6 Subjects
Abstract:
... Ma-Nuo-Xi Decoction (MNXD) is well-known in Tibetan medicine to be in line with the theory of treatment determination based on syndrome differentiation. However, the components responsible for its immunomodulating effect are unknown. In this study, three polysaccharide components—MNXD-P, MNXD-BD-P, and MNXD-AD-P—were isolated from MNXD and its basic and auxiliary prescription decoctions, of which ...
DOI:
10.1016/j.ijbiomac.2019.12.042

16. Timeliness and equity of infant pertussis vaccination in wales: Analysis of the three dose primary course

Author:
Perry, Malorie; McGowan, Anne; Roberts, Richard; Cottrell, Simon
Source:
Vaccine 2020 v.38 no.6 pp. 1402-1407
ISSN:
0264-410X
Subject:
maternal immunity,   etc   ; children; death; infants; monitoring; risk; vaccination; vaccines; Wales;     Show all 9 Subjects
Abstract:
... Infants aged under one year are at the highest risk of severe complications or death from pertussis infection. Prompt vaccination with a three dose course at two, three and four months of age decreases the amount of time they are vulnerable following waning of maternal antibodies. In Wales, uptake of all three doses of the primary course of pertussis containing vaccine is high. However, timeliness ...
DOI:
10.1016/j.vaccine.2019.12.001

17. Estimating contact-adjusted immunity levels against measles in South Korea and prospects for maintaining elimination status

Author:
Chun, June Young; Park, Wan Beom; Kim, Nam Joong; Choi, Eun Hwa; Funk, Sebastian; Oh, Myoung-don
Source:
Vaccine 2020 v.38 no.2 pp. 107-111
ISSN:
0264-410X
Subject:
herd immunity,   etc   ; measles; seroprevalence; vaccination; vaccines; South Korea;     Show all 6 Subjects
Abstract:
... Measles has been reemerging in South Korea since December 2018 resulting in 185 cases by September 2019.We calculated contact-adjusted immunity levels against measles in South Korea using national seroprevalence data in 2014, vaccination uptake rates, and an age-specific contact matrix. We further explored options to achieve a contact-adjusted immunity level of 93% for herd immunity.The assessed c ...
DOI:
10.1016/j.vaccine.2019.10.040
PubMed:
31679860
PubMed Central:
PMC6964151

18. Fine-Tuning Immunity: Players and Regulators for Plant NLRs

Author:
Sun, Yang; Zhu, Yu-Xiu; Balint-Kurti, Peter J.; Wang, Guan-Feng
Source:
Trends in plant science 2020
ISSN:
1360-1385
Subject:
innate immunity,   etc   ; chemical interactions; engineering; immunologic receptors; pathogens; surveys;     Show all 6 Subjects
Abstract:
... Plants have evolved a sophisticated innate immune system to defend against pathogen infection, and intracellular nucleotide-binding, leucine-rich repeat (NLR or NB-LRR) immune receptors are one of the main components of this system. NLR activity is fine-tuned by intra- and intermolecular interactions. We survey what is known about the conservation and diversity of NLR-interacting proteins, and div ...
DOI:
10.1016/j.tplants.2020.02.008

19. Neutrophils, monocytes and other immune components in the equine endometrium: Friends or foes?

Author:
Skarzynski, Dariusz J.; Szóstek-Mioduchowska, Anna Z.; Rebordão, Maria Rosa; Jalali, Beenu Moza; Piotrowska-Tomala, Katarzyna K.; Leciejewska, Natalia; Łazarczyk, Miriam; Ferreira-Dias, Graça M.
Source:
Theriogenology 2020 v.150 pp. 150-157
ISSN:
0093-691X
Subject:
adaptive immunity; innate immunity,   etc   ; bacteria; corpus luteum; cytokines; endometritis; endometrium; estrogens; estrus; fibrosis; genes; horse diseases; immune response; macrophages; mares; mast cells; monocytes; neutrophils; pathogenesis; pathogens; pregnancy;     Show all 21 Subjects
Abstract:
... The innate and adaptive immune mechanisms are key components of regulation of reproductive physiological function and uterine disorders in equine uterus. The predominant immunological response in equine endometrium, characterized by an innate immune response, occurs under estrogens influence, in the follicular phase. Although, the increase in immune-related genes in equine endometrium during estru ...
DOI:
10.1016/j.theriogenology.2020.01.018

20. Drivers and regulators of humoral innate immune responses to infection and cancer

Author:
Kumar, Deepak; Romero, Yeni; Schuck, Kaitlynn N.; Smalley, Haley; Subedi, Bibek; Fleming, Sherry D.
Source:
Molecular immunology 2020 v.121 pp. 99-110
ISSN:
0161-5890
Subject:
adaptive immunity; innate immunity,   etc   ; B-lymphocytes; antibodies; antigens; apoptosis; blood plasma; complement; homeostasis; immune response; immunoglobulin M; neoplasm cells; neoplasms; neutralization; pathogens; regulatory proteins;     Show all 16 Subjects
Abstract:
... The complement cascade consists of cell bound and serum proteins acting together to protect the host from pathogens, remove cancerous cells and effectively links innate and adaptive immune responses. Despite its usefulness in microbial neutralization and clearance of cancerous cells, excessive complement activation causes an immune imbalance and tissue damage in the host. Hence, a series of comple ...
DOI:
10.1016/j.molimm.2020.03.005
PubMed:
32199212
PubMed Central:
PMC7207242