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Camelia Savulescu; Pavla Krizova; Palle Valentiner-Branth; Shamez Ladhani; Hanna Rinta-Kokko; Corinne Levy; Jolita Mereckiene; Mirjam Knol; Brita A. Winje; Pilar Ciruela; Sara de Miguel; Marcela Guevara; Laura MacDonald; Jana Kozakova; Hans-Christian Slotved; Norman K. Fry; J. Pekka Nuorti; Kostas Danis; Mary Corcoran; Arie van der Ende; Didrik F. Vestrheim; Carmen Munoz-Almagro; Juan-Carlos Sanz; Jesus Castilla; Andrew Smith; Edoardo Colzani; Lucia Pastore Celentano; Germaine Hanquet; SpIDnet VE study group
secondary immunization, etc ; Streptococcus pneumoniae; odds ratio; serotypes; vaccination; vaccines; Show all 6 Subjects
Abstract:
... Pneumococcal conjugate vaccines covering 10 (PCV10) and 13 (PCV13) serotypes have been introduced in the infant immunization schedule of most European countries in 2010-11. To provide additional real-life data, we measured the effectiveness of PCV10 and PCV13 against invasive pneumococcal disease (IPD)in children of 12 European sites (SpIDnet). We compared the vaccination status of PCV10 and PCV13 ...
immunization, etc ; abortion (animals); conception; databases; fetal death; monitoring; vaccines; Show all 7 Subjects
Abstract:
... GSK initiated a Pregnancy Registry in the United States (US) for the reduced-antigen-content tetanus-diphtheria-acellular pertussis (Tdap; Boostrix, GSK) vaccine with the aim to detect and describe pregnancy outcomes in women vaccinated with Boostrix 28 days before estimated conception or during pregnancy. Voluntary reports of pregnancy exposure to Boostrix received from spontaneous and post-marke ...
immunization, etc ; children; education; employment; regression analysis; socioeconomics; surveys; vaccines; Indonesia; Show all 9 Subjects
Abstract:
... The success of a basic immunization program among children has been known as the cheapest and most effective approach in improving child survival against preventable diseases. This study aims to examine the determinant factors at the individual and contextual level that affect the provision of complete basic immunization for children aged 12–23 months in Sumatra, Indonesia. Using the 2020 Indonesi ...
Erin Sparrow; Ifedayo Adetifa; Nathorn Chaiyakunapruk; Thomas Cherian; Deshayne B. Fell; Barney S. Graham; Bruce Innis; David C. Kaslow; Ruth A. Karron; Harish Nair; Kathleen M. Neuzil; Samir Saha; Peter G. Smith; Padmini Srikantiah; Fred Were; Heather J. Zar; Daniel Feikin
immunization, etc ; Respiratory syncytial virus; World Health Organization; public health; vaccines; Show all 5 Subjects
Abstract:
... World Health Organization (WHO) preferred product characteristics describe preferences for product attributes that would help optimize value and use to address global public health needs, with a particular focus on low- and middle-income countries. Having previously published preferred product characteristics for both maternal and paediatric respiratory syncytial virus (RSV) vaccines, WHO recently ...
immunization, etc ; Enterovirus C; dynamic models; immunogenicity; mucosal immunity; risk; serotypes; vaccines; Show all 8 Subjects
Abstract:
... The global withdrawal of trivalent oral poliovirus vaccine (OPV) (tOPV, containing Sabin poliovirus strains serotypes 1, 2 and 3) from routine immunization, and the introduction of bivalent OPV (bOPV, containing Sabin poliovirus strains serotypes 1 and 3) and trivalent inactivated poliovirus vaccine (IPV) into routine immunization was expected to improve population serologic and mucosal immunity t ...
immunization, etc ; DNA; Orthomyxoviridae; albumins; anion exchange chromatography; hemagglutinins; influenza; purification methods; viruses; Show all 9 Subjects
Abstract:
... Immunization is the most effective way to respond to an influenza epidemic. To produce Vero cell-derived influenza vaccines, a more efficient, stable and economical purification process is required. In this study, we purified the H7N9 influenza virus grown in Vero cells that were cultured in a serum-free medium by using a combination of anion exchange chromatography (AEC) and ligand-activated core ...
immunization, etc ; Streptococcus pneumoniae; etiology; morbidity; mortality; pneumonia; regression analysis; vaccines; British Columbia; Show all 9 Subjects
Abstract:
... Pneumonia is a leading cause of morbidity and mortality globally. We determined the impact of 13-valent pneumococcal conjugate vaccine (PCV13) use on community-acquired pneumonia (CAP) rates eight years after the vaccine was introduced in the infant immunization program. Using diagnostic codes from administrative databases, we calculated the overall and age-specific CAP incidence per month (2000–2 ...
immunization, etc ; COVID-19 infection; Philippines; environmental monitoring; serotypes; sewage; vaccines; viruses; Malaysia; Show all 9 Subjects
Abstract:
... Concurrent outbreaks of circulating vaccine-derived poliovirus serotypes 1 and 2 (cVDPV1, cVDPV2) were confirmed in the Republic of the Philippines in September 2019 and were subsequently confirmed in Malaysia by early 2020. There is continuous population subgroup movement in specific geographies between the two countries. Outbreak response efforts focused on sequential supplemental immunization a ...
Frédéric Debellut; Rouden Mkisi; Vincent Masoo; Mike Chisema; Dennis Mwagomba; Mphatso Mtenje; Fumbani Limani; Donnie Mategula; Boston Zimba; Clint Pecenka
immunization, etc ; World Health Organization; children; decision making; funding; typhoid fever; vaccines; Malawi; Show all 8 Subjects
Abstract:
... There is a substantial typhoid burden in sub-Saharan Africa, and TCV has been introduced in two African countries to date. Decision-makers in Malawi decided to introduce TCV and applied for financial support from Gavi, the Vaccine Alliance in 2020. The current plan is to introduce TCV as part of the national immunization program in late 2022. The introduction will include a nationwide campaign tar ...
immunization, etc ; Enterovirus C; humoral immunity; intestines; mucosal immunity; risk; risk reduction; serotypes; vaccines; Show all 9 Subjects
Abstract:
... Delivering inactivated poliovirus vaccine (IPV) with oral poliovirus vaccine (OPV) in campaigns has been explored to accelerate the control of type 2 circulating vaccine-derived poliovirus (cVDPV) outbreaks. A review of scientific literature suggests that among populations with high prevalence of OPV failure, a booster with IPV after at least two doses of OPV may close remaining humoral and mucosa ...
immunization, etc ; abortion (animals); death; fetal death; infancy; meta-analysis; risk; systematic review; vaccines; Show all 9 Subjects
Abstract:
... Several countries have introduced maternal immunisation with pertussis vaccine to provide protection against pertussis in early infancy. There is increasing interest in non-specific effects of vaccines including that non-live vaccines may enhance susceptibility to non-targeted infections in females. Some studies have shown increased risk of chorioamnionitis among women receiving pertussis vaccine ...
Matthew Gagne; Juan I. Moliva; Kathryn E. Foulds; Shayne F. Andrew; Barbara J. Flynn; Anne P. Werner; Danielle A. Wagner; I-Ting Teng; Bob C. Lin; Christopher Moore; Nazaire Jean-Baptiste; Robin Carroll; Stephanie L. Foster; Mit Patel; Madison Ellis; Venkata-Viswanadh Edara; Nahara Vargas Maldonado; Mahnaz Minai; Lauren McCormick; Christopher Cole Honeycutt; Bianca M. Nagata; Kevin W. Bock; Caitlyn N.M. Dulan; Jamilet Cordon; Dillon R. Flebbe; John-Paul M. Todd; Elizabeth McCarthy; Laurent Pessaint; Alex Van Ry; Brandon Narvaez; Daniel Valentin; Anthony Cook; Alan Dodson; Katelyn Steingrebe; Saule T. Nurmukhambetova; Sucheta Godbole; Amy R. Henry; Farida Laboune; Jesmine Roberts-Torres; Cynthia G. Lorang; Shivani Amin; Jessica Trost; Mursal Naisan; Manjula Basappa; Jacquelyn Willis; Lingshu Wang; Wei Shi; Nicole A. Doria-Rose; Yi Zhang; Eun Sung Yang; Kwanyee Leung; Sijy O’Dell; Stephen D. Schmidt; Adam S. Olia; Cuiping Liu; Darcy R. Harris; Gwo-Yu Chuang; Guillaume Stewart-Jones; Isabella Renzi; Yen-Ting Lai; Agata Malinowski; Kai Wu; John R. Mascola; Andrea Carfi; Peter D. Kwong; Darin K. Edwards; Mark G. Lewis; Hanne Andersen; Kizzmekia S. Corbett; Martha C. Nason; Adrian B. McDermott; Mehul S. Suthar; Ian N. Moore; Mario Roederer; Nancy J. Sullivan; Daniel C. Douek; Robert A. Seder
immunization, etc ; B-lymphocytes; Severe acute respiratory syndrome coronavirus 2; immunity; neutralization; virus replication; Show all 6 Subjects
Abstract:
... SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to neutralization following immunization with ancestral spike-matched vaccines. It is unclear whether boosting with Omicron-matched vaccines would enhance protection. Here, nonhuman primates that received mRNA-1273 at weeks 0 and 4 were boosted at week 41 with mRNA-1273 or mRNA-Omicron. Neutralizing titers against D614G were ...
Jonathan Zintgraff; Paula Gagetti; Daniela Napoli; Nahuel Sanchez Eluchans; Lucia Irazu; Maria Moscoloni; Mabel Regueira; Claudia S. Lara; Alejandra Corso; Argentina Spn Working Group
immunization, etc ; Streptococcus pneumoniae; agar; antibiotic resistance; epidemiology; erythromycin; monitoring; morbidity; mortality; serotypes; vaccines; Argentina; Show all 12 Subjects
Abstract:
... Streptococcus pneumoniae is a major cause of severe invasive disease associated with high mortality and morbidity worldwide. A total of 2908 pneumococcal isolates were analyzed between 2006 and 2019. Gold standard pneumococcal serotyping (the Neufeld-Quellung reaction) was performed to identify the serotypes associated with infection in children < 5 years in Argentina and agar dilution method was ...
Selma Osman; Natasha Crowcroft; Elizabeth McLachlan; Todd Hatchette; Carol Perez-Iratxeta; Eugene Joh; James Wright; Scott A. Halperin; Shelley Deeks; Sarah Wilson; Sarah Buchan; Brian Ward; Jonathan Gubbay; Marc Brisson; Bouchra Serhir; Alberto Severini; Shelly Bolotin
immunization, etc ; adults; confidence interval; immunity; measles; neutralization tests; risk assessment; seroprevalence; surveys; vaccines; Canada; Show all 11 Subjects
Abstract:
... We aimed to determine population immunity to measles in Canada, and to assess the risk of future outbreaks. We tested 11,176 sera from Cycles 2 (2009–2011) and 3 (2011–2013) cohorts from the biobank of Statistics Canada’s Canadian Health Measures Survey (CHMS) using the BioPlex 2220 MMRV IgG assay. We then tested all BioPlex negative and equivocal samples using a more sensitive Plaque Reduction Ne ...
immunization, etc ; Haemonchus; blood serum; camels; electrophoresis; immunoblotting; immunoglobulin G; molecular weight; peroxidase; rabbits; research; Show all 11 Subjects
Abstract:
... The present study was aimed to develop anti-camel immunoglobulin G (IgG) conjugate. Camel serum was obtained from healthy camels and the IgG was extracted from this serum using the commercially available IgG purification kits. The electrophoretic profile of camel IgG showed four bands of molecular weight 66, 50, 44 and 33 kDa. Two rabbits were immunised with the purified camel IgG for production o ...
immunization, etc ; T-lymphocytes; adjuvants; antigens; chitosan; electrophoresis; interleukin-4; ovalbumin; plasmids; splenocytes; transfection; zeta potential; Show all 12 Subjects
Abstract:
... MiR-155 could act as a key modulator of different aspects of immune system including Th1 responses. In this study, we designed chitosan nanoparticles containing miR-155-expressing plasmid and explored their effects as an adjuvant to enhance Th1 responses for potential future application against intracellular pathogens. Nanoparticles were formulated by complex coacervation method and characterized ...
... The aims of the present study were to evaluate the ability of a subunit vaccine composed of recombinant molecules of α-toxin, β-toxin, FnBPA and ClfA, formulated with cationic liposomes and CpG-ODN, to confer protection against natural S. aureus intramammary infection (IMI) and to assess the antibody response against the vaccine components. A stringent criterion based on molecular identification o ...
Catherine Ji; Pierre-Philippe Piché-Renaud; Jemisha Apajee; Ellen Stephenson; Milena Forte; Jeremy N. Friedman; Michelle Science; Stanley Zlotkin; Shaun K. Morris; Karen Tu
immunization, etc ; COVID-19 infection; childhood; cohort studies; databases; medical records; pandemic; public health; vaccines; Ontario; Show all 10 Subjects
Abstract:
... The COVID-19 pandemic has caused a disruption in childhood immunization coverage around the world. This study aimed to determine the change in immunization coverage for children under 2 years old in Ontario, Canada, comparing time periods pre-pandemic to during the first year of the pandemic. Observational retrospective open cohort study, using primary care electronic medical record data from the ...
... Photodynamic therapy (PDT) and immunotherapy are considered promising methods for the treatment of tumors. However, these treatment systems are still suffering from shortcomings such as hypoxia, easy metastasis, and delayed immune response during PDT. Therefore, it is still challenging to establish a programmed and rapid response immune combination therapy platform. Here, we construct a two-step s ...
... This study was undertaken for the development of novel techniques that are based on immunoneutralization of inhibin bioactivity to improve Holstein cow fertility. A series of 4 experiments were carried out on 2 farms that were located in subtropical or temperate regions, to test the effects of immunization against inhibin alpha subunit on cow fertility under varying degrees of heat stress conditio ...