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1. Global vaccine action plan lessons learned I: Recommendations for the next decade

Author:
MacDonald, Noni; Mohsni, Ezzeddine; Al-Mazrou, Yagob; Kim Andrus, Jon; Arora, Narendra; Elden, Susan; Madrid, Marie-Yvette; Martin, Rebecca; Mahmoud Mustafa, Amani; Rees, Helen; Salisbury, David; Zhao, Qinjian; Jones, Ian; Steffen, Christoph A.; Hombach, Joachim; O'Brien, Katherine L.; Cravioto, Alejandro
Source:
Vaccine 2020 v.38 no.33 pp. 5364-5371
ISSN:
0264-410X
Subject:
immunization,   etc   ; experts; monitoring; vaccines;     Show all 4 Subjects
Abstract:
... The Global Vaccine Action Plan 2011–2020 (GVAP) was developed to realize the ambitions of the Decade of Vaccines – that all individuals and communities enjoy lives free from vaccine-preventable diseases. It included a comprehensive monitoring and evaluation/accountability framework to assess progress towards global targets with recommendations for corrective actions. While many of the GVAP targets ...
DOI:
10.1016/j.vaccine.2020.05.003

2. Immunization stress-related response – Redefining immunization anxiety-related reaction as an adverse event following immunization

Author:
Gold, Michael S.; MacDonald, Noni E.; McMurtry, C. Meghan; Balakrishnan, Madhava Ram; Heininger, Ulrich; Menning, Lisa; Benes, Oleg; Pless, Robert; Zuber, Patrick L.F.
Source:
Vaccine 2020 v.38 no.14 pp. 3015-3020
ISSN:
0264-410X
Subject:
immunization,   etc   ; medical sciences; terminology; vaccines;     Show all 4 Subjects
Abstract:
... The Council for the International Organizations of Medical Sciences (CIOMS) and WHO working group on pharmacovigilance defines five cause specific AEFI which includes an immunization anxiety-related reaction. Historically this term has been used to describe a range of symptoms and signs that may arise after immunization that are related to “anxiety” about the immunization. However, the term “anxie ...
DOI:
10.1016/j.vaccine.2020.02.046

3. Social mobilization for cholera prevention & control in India: Building on the existing framework

Author:
Gupta, Sanjukta Sen; Gupta, Satish Kumar
Source:
Vaccine 2020 v.38 pp. A181
ISSN:
0264-410X
Subject:
immunization,   etc   ; cholera; disasters; guidelines; vaccines; Haiti; India;     Show all 7 Subjects
Abstract:
... Social mobilization is an important component of the delivery of vaccines and has to be carried out at different levels. It plays a very critical role in success of a campaign, as was shown by the Polio eradication program in India that was supported by SMNet, a platform created for the purpose. Learnings from this has been used for other vaccine deployments in India as well. In addition, there is ...
DOI:
10.1016/j.vaccine.2019.07.047

4. GAVI, the Vaccine Alliance

Author:
Zerhouni, Elias
Source:
Cell 2019 v.179 no.1 pp. 13-17
ISSN:
0092-8674
Subject:
immunization,   etc   ; childhood; vaccines;     Show all 3 Subjects
Abstract:
... This year’s Lasker-Bloomberg Public Service Award goes to GAVI, the Vaccine Alliance, for providing sustained access to childhood vaccines around the globe, saving millions of lives, and highlighting the power of immunization to prevent disease. ...
DOI:
10.1016/j.cell.2019.08.026

5. Avoidance of Self during CRISPR Immunization

Author:
Weissman, Jake L.; Stoltzfus, Arlin; Westra, Edze R.; Johnson, Philip L.F.
Source:
Trends in microbiology 2020 v.28 no.7 pp. 543-553
ISSN:
0966-842X
Subject:
immunization,   etc   ; gene editing; immunologic memory; prokaryotic cells; viruses;     Show all 5 Subjects
Abstract:
... The battle between microbes and their viruses is ancient and ongoing. Clustered regularly interspaced short palindromic repeat (CRISPR) immunity, the first and, to date, only form of adaptive immunity found in prokaryotes, represents a flexible mechanism to recall past infections while also adapting to a changing pathogenic environment. Critical to the role of CRISPR as an adaptive immune mechanis ...
DOI:
10.1016/j.tim.2020.02.005

6. The binomial nature of immunization session size distributions and the implications for vaccine wastage

Author:
Colrain, Paul; Chang Blanc, Diana; Grundy, John; Kone, Solo
Source:
Vaccine 2020 v.38 no.16 pp. 3271-3279
ISSN:
0264-410X
Subject:
immunization,   etc   ; models; monitoring; operations research; planning; statistics; vaccines; watersheds;     Show all 8 Subjects
Abstract:
... In this paper we demonstrate that immunization session size distributions are governed by binomial statistics and determined by just two readily available programmatic parameters, the birth cohort of the catchment area and the session frequency. Given this new knowledge, the unavoidable component of an immunization facility’s opened vial wastage rate can be determined algebraically for each vial s ...
DOI:
10.1016/j.vaccine.2020.02.064

7. Extracellular vesicles as a platform to study cell-surface membrane proteins

Author:
Delauzun, Vincent; Amigues, Beatrice; Gaubert, Anais; Leone, Philippe; Grange, Magali; Gauthier, Laurent; Roussel, Alain
Source:
Methods 2020
ISSN:
1046-2023
Subject:
immunization,   etc   ; artificial membranes; detergents; ligands; membrane proteins; protein structure; solubilization;     Show all 7 Subjects
Abstract:
... Producing intact recombinant membrane proteins for structural studies is an inherently challenging task due to their requirement for a cell-lipid environment. Most of the procedures developed involve isolating the protein by solubilization with detergent and further reconstitutions into artificial membranes. These procedures are highly time consuming and suffer from further drawbacks, including lo ...
DOI:
10.1016/j.ymeth.2020.03.004

8. Augmented immune responses to a booster dose of oral cholera vaccine in Bangladeshi children less than 5 years of age: Revaccination after an interval of over three years of primary vaccination with a single dose of vaccine

Author:
Chowdhury, Fahima; Bhuiyan, Taufiqur Rahman; Akter, Afroza; Bhuiyan, Md Saruar; Khan, Ashraful Islam; Tauheed, Imam; Ahmed, Tasnuva; Ferdous, Jannatul; Dash, Pinki; Basher, Salima Raiyan; Hakim, Al; Lynch, Julia; Kim, Jerome H.; Excler, Jean-Louis; Kim, Deok Ryun; Clemens, John D.; Qadri, Firdausi
Source:
Vaccine 2020 v.38 no.7 pp. 1753-1761
ISSN:
0264-410X
Subject:
secondary immunization,   etc   ; adults; blood; children; cholera; immunoglobulin A; vaccination; vaccines;     Show all 8 Subjects
Abstract:
... We have earlier reported that a single dose of oral cholera vaccine (OCV) is protective in adults and children ≥5 years of age and sustained for 2 years. We enrolled participants (n = 240) from this study, between March-September 2017, over 3 years after receiving a primary single dose. Immune responses were measured in placebo group (Primary Immunization group: PI) and compared with those who rec ...
DOI:
10.1016/j.vaccine.2019.12.034
PubMed:
31879124
PubMed Central:
PMC7014297

9. Parental awareness of Meningococcal B vaccines and willingness to vaccinate their teens

Author:
Basta, Nicole E.; Becker, Andrew B.; Li, Qingxiao; Nederhoff, Dawn
Source:
Vaccine 2019 v.37 no.4 pp. 670-676
ISSN:
0264-410X
Subject:
immunization,   etc   ; exhibitions; parents; vaccines; Minnesota;     Show all 5 Subjects
Abstract:
... In the US, Meningococcal B (MenB) vaccines were first licensed in 2014. In 2015, the Advisory Committee on Immunization Practices recommended that parents of teens talk to their provider about receiving MenB vaccine, rather than issuing a routine recommendation. We assessed parental awareness of MenB vaccines and willingness to vaccinate their teens with MenB vaccines compared to MenACWY vaccines, ...
DOI:
10.1016/j.vaccine.2018.11.078
PubMed:
30587431
PubMed Central:
PMC6441613

10. Modified intermediate pore blockage model describes fouling behavior during sterile filtration of glycoconjugate vaccines

Author:
Emami, Parinaz; Fallahianbijan, Fatemeh; Dinse, Erica; Motevalian, Seyed Pouria; Conde, Brenda Carrillo; Reilly, Kelvin; Zydney, Andrew L.
Source:
Journal of membrane science 2020 v.613 pp. 118495
ISSN:
0376-7388
Subject:
immunization,   etc   ; artificial membranes; bacterial infections; biopharmaceuticals; confocal microscopy; filtration; fouling; models; porosity; thermoplastics; vaccines;     Show all 11 Subjects
Abstract:
... Sterile filtration using 0.2 μm pore size membranes is used to insure sterility of almost all biopharmaceuticals. Sterile filtration can be particularly challenging with large complex molecules such as glycoconjugate vaccines that are nearly 200 nm in size, leading to low yield and capacity. The objective of this study was to develop a fundamental understanding of the fouling behavior during steri ...
DOI:
10.1016/j.memsci.2020.118495

11. Comparison of anti-capsular antibody quantity and functionality in children after different primary dose and booster schedules of 13 valent-pneumococcal conjugate vaccine

Author:
Kaur, Ravinder; Pichichero, Michael
Source:
Vaccine 2020 v.38 no.28 pp. 4423-4431
ISSN:
0264-410X
Subject:
immunization,   etc   ; Streptococcus pneumoniae; antibodies; blood serum; childhood; children; immunoglobulin G; serotypes; vaccines; United States;     Show all 10 Subjects
Abstract:
... Different schedules for pediatric use of the 13-valent pneumococcal conjugate vaccine (PCV-13) are recommended in different countries and the U.S. Advisory Committee on Immunization Practices (ACIP) has considered potential of changing from 3 primary doses plus a booster (3p + 1) to two primary doses plus a booster (2p + 1) for protection against Streptococcus pneumoniae. In this paper, we report ...
DOI:
10.1016/j.vaccine.2020.04.063

12. Persistence of bactericidal antibodies following primary and booster MenACWY-TT vaccination of toddlers: A review of clinical studies

Author:
Webber, Chris; Peyrani, Paula; Balmer, Paul; Serra, Lidia
Source:
Vaccine 2020 v.38 no.27 pp. 4236-4245
ISSN:
0264-410X
Subject:
secondary immunization,   etc   ; adolescence; antibodies; children; immunologic memory; randomized clinical trials; risk; serotypes; tetanus; toddlers; vaccination; vaccines;     Show all 12 Subjects
Abstract:
... The long-term persistence of antibody responses following primary vaccination with quadrivalent conjugate vaccines targeting meningococcal serogroups A, C, W, and Y (MenACWY) and the duration of protection following a booster dose have not been fully elucidated, particularly in children who received primary dosing as toddlers. This review summarizes the findings of one phase 3 and three phase 2 op ...
DOI:
10.1016/j.vaccine.2020.02.048

13. An opportunity to incentivize innovation to increase vaccine safety in the United States by improving vaccine delivery using vaccine patches

Author:
Thompson, Kimberly M.; Orenstein, Walter A.; Hinman, Alan R.
Source:
Vaccine 2020 v.38 no.25 pp. 4060-4065
ISSN:
0264-410X
Subject:
immunization,   etc   ; business enterprises; cost effectiveness; economic incentives; funding; laws and regulations; vaccine development; vaccines; United States;     Show all 9 Subjects
Abstract:
... Vaccines represent cost-effective and safe interventions that provide substantial health and economic benefits to individuals and populations. The US vaccine enterprise that supports all aspects of immunization continues to encourage innovation. Despite some limited historical recommendations to create a fund to support investments in vaccine safety, and recent legislation that supports innovation ...
DOI:
10.1016/j.vaccine.2020.04.044
PubMed:
32345447
PubMed Central:
PMC7172634

14. The impact of PCV7/13 on the distribution of carried pneumococcal serotypes and on pilus prevalence; 14 years of repeated cross-sectional surveillance

Author:
Kasher, Melody; Roizin, Hector; Cohen, Adi; Jaber, Hanaa; Mikhailov, Sharon; Rubin, Carmit; Doron, Daphna; Rahav, Galia; Regev-Yochay, Gili
Source:
Vaccine 2020 v.38 no.19 pp. 3591-3599
ISSN:
0264-410X
Subject:
immunization,   etc   ; Streptococcus pneumoniae; children; fimbriae; monitoring; physicians; serotypes; vaccines; virulence; Israel;     Show all 10 Subjects
Abstract:
... S. pneumoniae carriage by children is a major source of pneumococcal transmission, and the initial step prior to infection. Pilus type 1, reported in ~30% of pneumococcal strains in the pre-vaccine era, contributes to pneumococcal colonization and virulence. In this study, we report the impact of the pneumococcal conjugate vaccine (PCV), PCV7/PCV13 sequential implementation on serotype distributio ...
DOI:
10.1016/j.vaccine.2020.03.016

15. Immunogenicity and safety of the RTS,S/AS01 malaria vaccine co-administered with measles, rubella and yellow fever vaccines in Ghanaian children: A phase IIIb, multi-center, non-inferiority, randomized, open, controlled trial

Author:
Asante, Kwaku Poku; Ansong, Daniel; Kaali, Seyram; Adjei, Samuel; Lievens, Marc; Nana Badu, Lydia; Agyapong Darko, Prince; Boakye Yiadom Buabeng, Patrick; Boahen, Owusu; Maria Rettig, Theresa; Agutu, Clara; Benard Ekow Harrison, Samuel; Ntiamoah, Yaw; Adomako Anim, Japhet; Adeniji, Elisha; Agordo Dornudo, Albert; Gvozdenovic, Emilia; Dosoo, David; Sambian, David; Owusu-Boateng, Harry; Ato Wilson, Elvis; Prempeh, Frank; Vandoolaeghe, Pascale; Schuerman, Lode; Owusu-Agyei, Seth; Agbenyega, Tsiri; Ofori-Anyinam, Opokua
Source:
Vaccine 2020 v.38 no.18 pp. 3411-3421
ISSN:
0264-410X
Subject:
immunization,   etc   ; antibody formation; children; immunogenicity; malaria vaccines; measles; surface antigens; viruses; vitamin A; yellow fever;     Show all 10 Subjects
Abstract:
... To optimize vaccine implementation visits for young children, it could be efficient to administer the first RTS,S/AS01 malaria vaccine dose during the Expanded Programme on Immunization (EPI) visit at 6 months of age together with Vitamin A supplementation and the third RTS,S/AS01 dose on the same day as yellow fever (YF), measles and rubella vaccines at 9 months of age. We evaluated the safety an ...
DOI:
10.1016/j.vaccine.2020.03.014

16. Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity

Author:
Lai, Jennifer I.; Eszterhas, Susan K.; Brooks, Seth A.; Guo, Chengzi; Zolla-Pazner, Susan; Seaman, Michael S.; Bailey-Kellogg, Chris; Griswold, Karl E.; Ackerman, Margaret E.
Source:
Vaccine 2020 v.38 no.18 pp. 3436-3446
ISSN:
0264-410X
Subject:
immunization,   etc   ; Human immunodeficiency virus 1; animal models; antibodies; antigens; immunogenicity; risk; vaccine development; vaccines;     Show all 9 Subjects
Abstract:
... Antibodies against the HIV-1 V1V2 loops were the only correlate of reduced infection risk in the RV144 vaccine trial, highlighting the V1V2 loops as promising targets for vaccine design. The V1V2 loops are structurally plastic, exhibiting either an α-helix-coil or β-strand conformation. V1V2-specific antibodies may thus recognize distinct conformations, and an antibody’s conformational specificity ...
DOI:
10.1016/j.vaccine.2020.03.010
PubMed:
32192810
PubMed Central:
PMC7132531

17. Skeleton binding protein 1 (SBP1) of Plasmodium falciparum accumulates in electron-dense material before passing through the parasitophorous vacuole membrane

Author:
Iriko, Hideyuki; Ishino, Tomoko; Tachibana, Mayumi; Omoda, Ayaka; Torii, Motomi; Tsuboi, Takafumi
Source:
Parasitology international 2020 v.75 pp. 102003
ISSN:
1383-5769
Subject:
immunization,   etc   ; Plasmodium falciparum; antibodies; binding proteins; endothelial cells; erythrocytes; microscopy; parasites; vacuoles;     Show all 9 Subjects
Abstract:
... Plasmodium falciparum proteins involved in vascular endothelial cell adherence are transported to the surface of infected erythrocytes. These proteins are exported through parasite-derived membrane structures within the erythrocyte cytoplasm called Maurer's clefts. Skeleton binding protein 1 (SBP1) is localized in the Maurer's clefts and plays an important role in transporting molecules to the sur ...
DOI:
10.1016/j.parint.2019.102003

18. Fatal outcomes following immunization errors as reported to the EudraVigilance: A case series

Author:
Hoeve, Christina E.; Gadroen, Kartini; Kwa, Marcel S.G.; van Haren, Anja; Sturkenboom, Miriam C.J.M.; Straus, Sabine M.J.M.
Source:
Vaccine 2020 v.38 no.15 pp. 3086-3095
ISSN:
0264-410X
Subject:
immunization,   etc   ; Streptococcus pneumoniae; adverse effects; education; influenza vaccines; live vaccines; measles; patients; quality control; rabies; screening;     Show all 11 Subjects
Abstract:
... Serious adverse reactions after immunization are rare but do occur. In very rare instances, cases with fatal outcome have been reported. These reports can have a huge impact and even more so when due to an immunization error. The aim of this study is to systematically review immunization errors with fatal outcomes in EudraVigilance.This was a case-series analysis of Individual Case Safety Reports ...
DOI:
10.1016/j.vaccine.2020.02.074

19. Diverse human VH antibody fragments with bio-therapeutic properties from the Crescendo Mouse

Author:
Teng, Yumin; Young, Joyce L.; Edwards, Bryan; Hayes, Philip; Thompson, Lorraine; Johnston, Colette; Edwards, Carolyn; Sanders, Yun; Writer, Michele; Pinto, Debora; Zhang, Yanjing; Roode, Mila; Chovanec, Peter; Matheson, Louise; Corcoran, Anne E.; Fernandez, Almudena; Montoliu, Lluis; Rossi, Beatrice; Tosato, Valentina; Gjuracic, Kresimir; Nikitin, Dmitri; Bruschi, Carlo; McGuinness, Brian; Sandal, Thomas; Romanos, Mike
Source:
New biotechnology 2020 v.55 pp. 65-76
ISSN:
1871-6784
Subject:
immunization,   etc   ; B-lymphocytes; Escherichia coli; antibodies; genes; genetically modified organisms; humans; immunoglobulins; loci; mice; phages;     Show all 11 Subjects
Abstract:
... We describe the ‘Crescendo Mouse’, a human VH transgenic platform combining an engineered heavy chain locus with diverse human heavy chain V, D and J genes, a modified mouse Cγ1 gene and complete 3’ regulatory region, in a triple knock-out (TKO) mouse background devoid of endogenous immunoglobulin expression. The addition of the engineered heavy chain locus to the TKO mouse restored B cell develop ...
DOI:
10.1016/j.nbt.2019.10.003

20. Programmatic Preparations and challenges for OCV introduction in India

Author:
Haldar, Pradeep
Source:
Vaccine 2020 v.38 pp. A175
ISSN:
0264-410X
Subject:
immunization,   etc   ; cholera; control methods; drinking water; edible vaccines; people; risk; sanitation; India;     Show all 9 Subjects
Abstract:
... Cholera mainly affects the marginalized with inequitable access to care, potable water and improved sanitation. An estimated 411 million people in India are at risk from cholera, with 675,188 cases and 20,256 deaths occurring annually. Given the global elimination plan for cholera by 2030, a multi-stakeholder strategy is required. The National Technical Advisory Group on Immunization (NTAGI) Worki ...
DOI:
10.1016/j.vaccine.2019.06.047