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You searched for: Subject "immunomodulators" Remove constraint Subject: "immunomodulators"
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1. Metabolomics driven analysis of Nigella sativa seeds identifies the impact of roasting on the chemical composition and immunomodulatory activity

Author:
Mohamed A. Salem; Riham A. El-Shiekh; Nora M. Aborehab; Ahmed A. Al‐Karmalawy; Shahira M. Ezzat; Saleh Alseekh; Alisdair R. Fernie
Source:
Food chemistry 2023 v.398 pp. 133906
ISSN:
0308-8146
Subject:
immunomodulators,   etc   ; Nigella sativa; cell lines; chemical composition; flavonoids; flavor; food chemistry; metabolites; metabolomics; monocytes; saponins;     Show all 11 Subjects
Abstract:
... Nigella sativa L. seeds (NS) are known as one of the most traditional immunomodulatory and nutritive food additives. NS can, furthermore, be roasted to give curries, breads, and other dishes a smoky, nutty flavor. This study evaluated the effect of roasting NS on the metabolic profile and immunomodulatory activity. Non-targeted metabolomics analysis was conducted using several analytical platforms ...
DOI:
10.1016/j.foodchem.2022.133906

2. Application of lignin and lignin-based composites in different tissue engineering fields

Author:
Yuqi Liu; Xucai Wang; Qiming Wu; Wenhui Pei; Miou Jing Teo; Zhefan Stephen Chen; Caoxing Huang
Source:
International journal of biological macromolecules 2022 v.222 pp. 994-1006
ISSN:
0141-8130
Subject:
immunomodulators,   etc   ; antioxidants; lignin; phytomass; systematic review;     Show all 5 Subjects
Abstract:
... Lignin is a major phenolic polymer from the plant biomass. Due to its abundant functional groups (carboxyl and hydroxyl groups), lignin could act as an antioxidant, antimicrobial as well as an immune modulator. These remarkable biological properties render lignin a highly potential bioactive candidate in the biomedical applications including tissue engineering. Although several effective applicati ...
DOI:
10.1016/j.ijbiomac.2022.09.267

3. Update on the management of vitamins and minerals in cystic fibrosis

Author:
Senthilkumar Sankararaman; Sara J. Hendrix; Terri Schindler
Source:
Nutrition in clinical practice 2022 v.37 no.5 pp. 1074-1087
ISSN:
0884-5336
Subject:
immunomodulators,   etc   ; biomarkers; cystic fibrosis; enteral feeding;     Show all 4 Subjects
Abstract:
... Advancements in respiratory and nutrition management have significantly improved the survival of patients with cystic fibrosis (CF). With the availability of several nutrition interventions such as oral/enteral nutrition supplements, enteric‐coated pancreatic enzymes, and water‐miscible CF‐specific vitamin supplements, frank vitamin deficiencies—with the exception of vitamin D—are rarely encounter ...
DOI:
10.1002/ncp.10899

4. The regulate function of polysaccharides and oligosaccharides that with sulfate group on immune-related disease

Author:
Ling Xu; Dan He; Changlin Zhang; Ying Bai; Cuili Zhang
Source:
Journal of functional foods 2022 v.88 pp. 104870
ISSN:
1756-4646
Subject:
immunomodulators,   etc   ; oligosaccharides; proteoglycans; solubility; sulfates; sulfuric acid;     Show all 6 Subjects
Abstract:
... Sulfate polysaccharide is a kind of polyanionic linear macromolecular compound which contained sulfate groups. In vivo, most of them combine with proteins to form proteoglycans. The oligosaccharides obtained by degradation from polysaccharides would have different biological activities. Sulfate polysaccharides and oligosaccharides have immunomodulatory activity, which can be involved in activating ...
DOI:
10.1016/j.jff.2021.104870

5. The immunomodulatory activity of degradation products of Sesbania cannabina galactomannan with different molecular weights

Author:
Yuheng Tao; Junmei Ma; Caoxing Huang; Chenhuan Lai; Zhe Ling; Qiang Yong
Source:
International journal of biological macromolecules 2022 v.205 pp. 530-538
ISSN:
0141-8130
Subject:
immunomodulators,   etc   ; Sesbania cannabina; ethanol; galactomannans; interleukin-6;     Show all 5 Subjects
Abstract:
... Galactomannan (GM) is widely recognized as an immune enhancer; however, the underlying molecular mechanism is still unknown. Herein, four products with molecular weights in descending order, namely GM40, GM50, GM65, and GMOS, were separated from incomplete degradation products of Sesbania cannabina GM by ethanol precipitation, followed by their immunomodulatory activity. Through FTIR and XPS spect ...
DOI:
10.1016/j.ijbiomac.2022.02.122

6. Discovery of nitric oxide-inducing activities of synthetic LAM glycan motifs prepared by scalable rapid syntheses

Author:
Nutchapong Suwanwong; Jaruwan Chatwichien; Kittipong Chainok; Somsak Ruchirawat; Siwarutt Boonyarattanakalin
Source:
Carbohydrate polymers 2022 v.296 pp. 119637
ISSN:
0144-8617
Subject:
immunomodulators,   etc   ; Mycobacterium tuberculosis; adjuvants; macrophages; polysaccharides; structure-activity relationships;     Show all 6 Subjects
Abstract:
... Enhancement of local nitric oxide (NO) concentration is important for the effectiveness of an adjuvant and for both innate and adaptive immunological responses. Currently, the information on the NO-inducing activities of lipoarabinomannan (LAM) glycan motifs on Mycobacterium tuberculosis (Mtb) is not possibly available. Thus, detailed studies on the structure-activity relationship of discrete LAM ...
DOI:
10.1016/j.carbpol.2022.119637

7. Ganoderma immunomodulatory proteins: mushrooming functional FIPs

Author:
Jingwei Lin; Huan Chen; Yudong Bai; Shoukun Li; Gengyuan Liang; Tianning Fan; Ningyuan Gao; Xiupeng Wu; Hui Li; Gang Chen; Yingxu Gao; Jungang Fan
Source:
Applied microbiology and biotechnology 2022 v.106 no.7 pp. 2367-2380
ISSN:
0175-7598
Subject:
immunomodulators,   etc   ; Ganoderma lucidum; antineoplastic activity; biotechnology; fungi; genes; immunomodulation;     Show all 7 Subjects
Abstract:
... Fungal immunomodulatory protein (FIP) is a novel functional protein family with specific immunomodulatory activity identified from several macro-fungi. A variety of biological activities of FIPs have been reported, such as anti-allergy, anti-tumor, mitogenic activity, and immunomodulation. Among all known FIPs, the firstly discovered FIP was isolated from Ganoderma lucidum, and most FIP members we ...
DOI:
10.1007/s00253-022-11839-9

8. Enhanced migration and immunoregulatory capacity of BMSCs mediated by overexpression of CXCR4 and IL-35

Author:
Chen Tan; Songwei Tan; Hao Zhang; Man Zhang; Heng Fan; Zhen Nan; Xingxing Liu; Wenzhu Wang; Lijuan Zhang; Shuangjiao Deng; Dongmei Zuo; Qing Tang
Source:
Molecular immunology 2022 v.150 pp. 1-8
ISSN:
0161-5890
Subject:
immunomodulators,   etc   ; genes; immune response; immunomodulation; interleukins; therapeutics; tissue repair;     Show all 7 Subjects
Abstract:
... Bone marrow-derived mesenchymal stem cells (BMSCs) have been widely studied for their applications in immunoregulation and tissue repair. However, the therapeutic effects of BMSCs in the body are limited, partly due to the low homing efficiency of BMSCs to affected parts. The stromal cell-derived factor 1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis is well known to play an essential role ...
DOI:
10.1016/j.molimm.2022.07.005

9. Arginine and glutamine supplementation on transthyretin levels in severely burned patients: A systematic review

Author:
Marcela Almeida Linden; Thais Longo de Morais Teixeira; Renata Germano Borges de Oliveira Nascimento Freitas; Maria Ângela Bellomo Brandão; Roberto José Negrão Nogueira
Source:
Nutrition 2022 v.101 pp. 111657
ISSN:
0899-9007
Subject:
immunomodulators,   etc   ; arginine; blood serum; energy; glutamine; nutrition; prealbumin; systematic review;     Show all 8 Subjects
Abstract:
... The aim of this study was to investigate the influence of supplementation with the immunomodulators arginine and glutamine on transthyretin levels in burn patients. This systematic review followed the protocol proposed and registered in PROSPERO (CRD42021239526) and was carried out following the PRISMA checklist for systematic reviews. Forty-four studies were evaluated. Of the 44, we included 6 fo ...
DOI:
10.1016/j.nut.2022.111657

10. Structural characteristics and biological activities of a pectic-polysaccharide from okra affected by ultrasound assisted metal-free Fenton reaction

Author:
Ding-Tao Wu; Yuan He; Meng-Xi Fu; Ren-You Gan; Yi-Chen Hu; Lian-Xin Peng; Gang Zhao; Liang Zou
Source:
Food hydrocolloids 2022 v.122 pp. 107085
ISSN:
0268-005X
Subject:
immunomodulators,   etc   ; esterification; hydrocolloids; molecular weight; okra; ultrasonics; uronic acids; viscosity;     Show all 8 Subjects
Abstract:
... This study aimed to investigate the impact of ultrasound assisted metal-free Fenton (H₂O₂-ascorbic acid system) reaction on structural and biological properties of a pectic-polysaccharide extracted from okra (OPP). Three degraded fractions (DOPP-1, DOPP-2, and DOPP-3) were successfully prepared by ultrasound assisted Fenton treatment of OPP for 0.5, 1.0, and 3.0 h, respectively. Molecular weights ...
DOI:
10.1016/j.foodhyd.2021.107085

11. Effects of selenylation modification on the antioxidative and immunoregulatory activities of polysaccharides from the pulp of Rose laevigata Michx fruit

Author:
Qiping Zhan; Yong Chen; Yifang Guo; Qian Wang; Hui Wu; Liyan Zhao
Source:
International journal of biological macromolecules 2022 v.206 pp. 242-254
ISSN:
0141-8130
Subject:
immunomodulators,   etc   ; antioxidant activity; erythrocytes; fruits; immunomodulation; macrophages; polysaccharides; pulp; selenium;     Show all 9 Subjects
Abstract:
... Selenylation modification has been widely utilized to improve the activity of polysaccharides and to develop novel sources of selenium (Se) supplements. A purified pulp polysaccharide of Rose laevigata Michx fruit (PPRLMF-2) was selenized into Se-PPRLMF-2 in this study. PPRLMF-2 + Se was formulated by Na₂SeO₃ according to the Se content of Se-PPRLMF-2. To investigate the effects of selenylation mo ...
DOI:
10.1016/j.ijbiomac.2022.02.149

12. ALVAC‐fIL2, a feline interleukin‐2 immunomodulator, as a treatment for sarcoids in horses: A pilot study

Author:
Corey Saba; Randall Eggleston; Andrew Parks; John Peroni; Eric Sjoberg; Shelbe Rice; Jesse Tyma; Jarred Williams; Deborah Grosenbaugh; A. Timothy Leard
Source:
Journal of veterinary internal medicine 2022 v.36 no.3 pp. 1179-1184
ISSN:
0891-6640
Subject:
immunomodulators,   etc   ; cats; horses; inflammation; interleukin-2; neoplasm progression; sarcoid; veterinary medicine;     Show all 8 Subjects
Abstract:
... BACKGROUND: Sarcoid tumors are common in horses and may negatively impact the performance and value of the horse. No known treatment is reliably successful. HYPOTHESES/OBJECTIVES: To determine tolerability, overall response rate, time to response, and progression‐free survival of horses with biopsy‐confirmed or suspected sarcoids treated with ALVAC‐fIL2. ANIMALS: Client‐owned horses with measurabl ...
DOI:
10.1111/jvim.16425

13. Design, synthesis, and preliminary immunopotentiating activity of new analogues of nojirimycin

Author:
Arun K. Thangarasu; Shainy Sambyal; Halmuthur Mahabalarao Sampath Kumar; Ravi S. Lankalapalli
Source:
Carbohydrate research 2022 v.511 pp. 108479
ISSN:
0008-6215
Subject:
immunomodulators,   etc   ; deoxynojirimycin; immunosuppression; interleukin-12; macrophages; mice; nitric oxide; research; secretion;     Show all 9 Subjects
Abstract:
... Three new classes of nojirimycin analogues viz. N-alkyl with C1-substituent (4-phenylbutyl), N-substituted 1-deoxynojirimycin and its congener δ-lactam, and a 4-phenylbutyl-β-C-glycoside were designed and synthesized for immunological studies. The resulting diverse compound library exhibited proliferation of B Cells and T cells induced by LPS and Con A, respectively. The majority of the analogues ...
DOI:
10.1016/j.carres.2021.108479

14. Nanomaterials with changeable physicochemical property for boosting cancer immunotherapy

Author:
Qiankun Ni; Fengfei Xu; Yufei Wang; Yujie Li; Guangchao Qing; Yuxuan Zhang; Jie Zhong; Jinghong Li; Xing-Jie Liang
Source:
Journal of controlled release 2022 v.342 pp. 210-227
ISSN:
0168-3659
Subject:
immunomodulators,   etc   ; T-lymphocytes; antigens; cancer vaccines; immune response; immunotherapy; immunotoxicity; neoplasms;     Show all 8 Subjects
Abstract:
... The past decade has witnessed a great progress in cancer immunotherapy with the sequential approvals of therapeutic cancer vaccine, immune checkpoint inhibitor and chimeric antigen receptor (CAR) T cell therapy. However, some hurdles still remain to the wide implementation of cancer immunotherapy, including low immune response, complex tumor heterogeneity, off-target immunotoxicity, poor solid tum ...
DOI:
10.1016/j.jconrel.2022.01.003

15. Yeast carboxymethyl-glucan improves endothelial function and inhibits platelet aggregation in spontaneously hypertensive rats

Author:
Lorena Soares Bezerra; Marciane Magnani; Tatiana Colombo Pimentel; Júlio César Pinheiro Lúcio de Oliveira; Francisca Manuela de Souza Freire; Arthur José Pontes Oliveira de Almeida; Mathania Silva de Almeida Rezende; Islânia Giselia Albuquerque Gonçalves; Isac Almeida de Medeiros; Robson Cavalcante Veras
Source:
Food & function 2022 v.13 no.9 pp. 5406-5415
ISSN:
2042-650X
Subject:
immunomodulators,   etc   ; bioactive properties; hypertension; placebos; platelet aggregation; reactive oxygen species; yeasts;     Show all 7 Subjects
Abstract:
... Carboxymethyl-glucan is a semi-synthetic derivative of β-d-glucan, a polysaccharide widely found in several natural sources, such as yeast, fungi, and cereals. This compound has beneficial effects on health and is considered an important immunomodulator. However, studies exploring carboxymethyl-glucan bioactivity in cardiovascular health remain lacking, mainly in hypertension. Thus, this study sou ...
DOI:
10.1039/d1fo03492h

16. Norfloxacin suppresses Leptospira-induced inflammation through inhibiting p65 and ERK phosphorylation and NLRP3 inflammasome activation

Author:
Xufeng Xie; Wenlong Zhang; Xi Chen; Dianjun Wu; Yongguo Cao
Source:
Microbial pathogenesis 2022 v.162 pp. 105315
ISSN:
0882-4010
Subject:
immunomodulators,   etc   ; Leptospira; antibacterial properties; inflammasomes; inflammation; leptospirosis; norfloxacin; pathogenesis; phosphorylation; zoonoses;     Show all 10 Subjects
Abstract:
... Leptospirosis is a worldwide re-emerging zoonosis caused by pathogenic Leptospira. Inflammatory storms induced by Leptospira are the reason to induce immunoparalysis and organ failures. Antibiotics are still the current mainstream treatment for leptospirosis. In addition to their antibacterial action, the immunomodulatory function of antibiotics has been paid more and more attention. In this study ...
DOI:
10.1016/j.micpath.2021.105315

17. β(2→6)-Type fructans attenuate proinflammatory responses in a structure dependent fashion via Toll-like receptors

Author:
C. Fernández-Lainez; R. Akkerman; M.M.P. Oerlemans; M.J. Logtenberg; H.A. Schols; L.A. Silva-Lagos; G. López-Velázquez; P. de Vos
Source:
Carbohydrate polymers 2022 v.277 pp. 118893
ISSN:
0144-8617
Subject:
immunomodulators,   etc   ; Toll-like receptors; computer simulation; cytokines; dendritic cells; fructans; inflammation; polymers;     Show all 8 Subjects
Abstract:
... Graminan-type fructans (GTFs) have demonstrated immune benefits. However, mechanisms underlying these benefits are unknown. We studied GTFs interaction with Toll-like receptors (TLRs), performed molecular docking and determined their impact on dendritic cells (DCs). Effects of GTFs were compared with those of inulin-type fructans (ITFs). Whereas ITFs only contained β(2→1)-linked fructans, GTFs sho ...
DOI:
10.1016/j.carbpol.2021.118893

18. Macrophage-targeted mannose-decorated PLGA-vegetable oil hybrid nanoparticles loaded with anti-inflammatory agents

Author:
Jana Ghitman; Gratiela Gradisteanu Pircalabioru; Adriana Zainea; Luminita Marutescu; Horia Iovu; Eugeniu Vasile; Cristina Stavarache; Bogdan Stefan Vasile; Raluca Stan
Source:
Colloids and surfaces 2022 v.213 pp. 112423
ISSN:
0927-7765
Subject:
immunomodulators,   etc   ; biocompatibility; emulsifying; encapsulation; fluorescence; hydrodynamics; lipophilicity; macrophages; mannose; therapeutics; vegetable oil;     Show all 11 Subjects
Abstract:
... This work pledge to extend the therapeutic windows of hybrid nanoparticulate systems by engineering mannose-decorated hybrid nanoparticles based on poly lactic-co-glycolic acid (PLGA) and vegetable oil for efficient delivery of two lipophilic anti-inflammatory therapeutics (Celecoxib-CL and Indomethacin-IMC) to macrophages. The mannose surface modification of nanoparticles is achieved via O-palmit ...
DOI:
10.1016/j.colsurfb.2022.112423

19. Modulation of Cellular Redox Parameters for Improving Therapeutic Responses in Multiple Myeloma

Author:
Alessandro Allegra; Claudia Petrarca; Mario Di Gioacchino; Marco Casciaro; Caterina Musolino; Sebastiano Gangemi
Source:
Antioxidants 2022 v.11 no.3 pp. -
ISSN:
2076-3921
Subject:
immunomodulators,   etc   ; autografting; drug resistance; homeostasis; myeloma; oxidative stress; proteasome endopeptidase complex; toxicity;     Show all 8 Subjects
Abstract:
... Raised oxidative stress and abnormal redox status are typical features of multiple myeloma cells, and the identification of the intimate mechanisms that regulate the relationships between neoplastic cells and redox homeostasis may reveal possible new anti-myeloma therapeutic targets to increase the effectiveness of anti-myeloma drugs synergistically or to eradicate drug-resistant clones while redu ...
DOI:
10.3390/antiox11030455

20. Robust tolerogenic dendritic cells via push/pull pairing of toll-like-receptor agonists and immunomodulators reduces EAE

Author:
Peter Deak; Hannah Riley Knight; Aaron Esser-Kahn
Source:
Biomaterials 2022 v.286 pp. 121571
ISSN:
0142-9612
Subject:
immunomodulators,   etc   ; antigens; biocompatible materials; dexamethasone; disease models; immunosuppression; ovalbumin; phenotype; simvastatin; therapeutics;     Show all 10 Subjects
Abstract:
... A failure of central immune tolerance driven by autoantigen specific T regulatory (Treg) cells is a major cause of many autoimmune diseases. Restoration of proper autoantigen Treg specific response holds promise as a highly effective, long-term therapy for a wide variety of autoimmune diseases. Generating autoantigen specific Tregs remains a challenge due to the non-specific nature of most toleriz ...
DOI:
10.1016/j.biomaterials.2022.121571