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- Author:
- Chitko, Carol; Chitko-McKown, Carol G.; Bierman, Stacy L.; Kuehn, Larry A.; Bennett, Gary L.; DeDonder, Keith D.; Apley, Michael D.; Harhay, Gregory P.; Clawson, Michael L.; White, Bradley J.; Larson, Robert L.; Capik, Sarah F.; Lubbers, Brian V.
- Source:
- Veterinary immunology and immunopathology 2021 v.237 pp. 110274
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; cattle; interleukin-6; Show all 3 Subjects
- Abstract:
- ... Commercially available bovine-specific assays are limited in number, and multiplex assays for this species are rare. Our objective was to develop a multiplex assay for the bovine inflammatory cytokines IL-1β, IL-6, and TNF-α using the Meso Scale Discovery U-PLEX platform. "Do-It-Yourself" ELISA kits that contained polyclonal antibodies, both unlabeled and biotinylated, and the specific recombinant ...
- Handle:
- 10113/7391751
- DOI:
- 10.1016/j.vetimm.2021.110274
-
https://dx.doi.org/10.1016/j.vetimm.2021.110274
- Author:
- Soler, Lourdes; Szczubiał, Marek; Dąbrowski, Roman; Płusa, Anna; Bochniarz, Mariola; Brodzki, Piotr; Lampreave, Fermín; Piñeiro, Matilde
- Source:
- Veterinary immunology and immunopathology 2021 v.235 pp. 110221
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; biomarkers; blood serum; haptoglobins; medicine; pyometra; Show all 6 Subjects
- Abstract:
- ... Measurement of acute phase proteins (APPs) as biomarkers in canine medicine is in increasing demand. In the present study, the development and validation of two ELISA methods for the quantification of canine inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) and haptoglobin (Hp) are shown. The adequate imprecision and accuracy and wide analytical range make the developed methods appropriate to qu ...
- DOI:
- 10.1016/j.vetimm.2021.110221
-
https://dx.doi.org/10.1016/j.vetimm.2021.110221
- Author:
- Celias, Daiana Pamela; Motrán, Claudia Cristina; Cervi, Laura
- Source:
- Trends in parasitology 2020 v.36 no.2 pp. 87-90
- ISSN:
- 1471-4922
- Subject:
- immunopathology, etc ; helminthiasis; helminths; inflammasomes; Show all 4 Subjects
- Abstract:
- ... Helminth infections can activate multimeric protein complexes called inflammasomes. In this forum we summarize the main effects of the NLRP3 inflammasome activation, including control of excessive Th2 response and immunopathology induction. These mechanisms would ensure the survival of both the host and the parasite. ...
- DOI:
- 10.1016/j.pt.2019.10.012
-
https://dx.doi.org/10.1016/j.pt.2019.10.012
- Author:
- Schnabel, Christiane L.; Babasyan, Susanna; Freer, Heather; Larson, Elisabeth M.; Wagner, Bettina
- Source:
- Veterinary immunology and immunopathology 2021 v.238 pp. 110284
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; biomarkers; flow cytometry; fluorescence; horses; inflammation; monocytes; necrosis; neoplasms; Show all 9 Subjects
- Abstract:
- ... Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine, that is involved in acute inflammation and is employed as a biomarker of inflammatory diseases in several species for which reliable quantification is available. We aimed to develop suitable tools to quantify TNF-α in equine samples. We generated two new mAbs against equine TNF-α (clones 48 and 292), evaluated their specificity for this cy ...
- DOI:
- 10.1016/j.vetimm.2021.110284
-
https://dx.doi.org/10.1016/j.vetimm.2021.110284
- Author:
- Sajiki, Y.; Konnai, S.; Ikenaka, Y.; Okagawa, T.; Maekawa, N.; Logullo, C.; da Silva Vaz, I.; Murata, S.; Ohashi, K.
- Source:
- Veterinary immunology and immunopathology 2021 v.236 pp. 110238
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; arachidonic acid; cattle; concanavalin A; immunosuppression; prostaglandin synthase; prostaglandins; Show all 7 Subjects
- Abstract:
- ... Prostaglandins (PGs) are lipid mediators derived from arachidonic acid by several enzymes including cyclooxygenase (COX)-1 and COX-2. We have previously shown that PGE₂ regulates immune responses, such as Th1 cytokine production and T-cell proliferation, in cattle. However, it is still unclear whether other PGs are involved in the regulation of immune responses in cattle.Here, immunosuppressive pr ...
- DOI:
- 10.1016/j.vetimm.2021.110238
-
https://dx.doi.org/10.1016/j.vetimm.2021.110238
- Author:
- Díaz, I.; Pujols, J.; Cano, E.; Cuadrado, R.; Navarro, N.; Mateu, E.; Martín, M.
- Source:
- Veterinary immunology and immunopathology 2021 v.234 pp. 110206
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; Porcine epidemic diarrhea virus; immune response; nucleocapsid proteins; Show all 4 Subjects
- Abstract:
- ... Three commercial ELISAs -two based on spike (E1 and E3) and one on nucleocapsid protein (E2)-were used to analyze the development and persistence of antibodies against Porcine epidemic diarrhea virus (PEDV). Seventy-five four-week-old PEDV-negative piglets were inoculated orally with a European G1b PEDV (INOC) and fourteen were kept as controls (CTRL). After the inoculation, E3 detected positive a ...
- DOI:
- 10.1016/j.vetimm.2021.110206
-
https://dx.doi.org/10.1016/j.vetimm.2021.110206
- Author:
- Pujol, Myriam; Guzman, Efrain; Montaner-Tarbes, Sergio; Montoya, Maria
- Source:
- Veterinary immunology and immunopathology 2021 v.234 pp. 110215
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; antigens; bone marrow; macrophages; monocytes; phenotype; swine; Show all 7 Subjects
- Abstract:
- ... Dendritic cells (DCs) are the most potent antigen presenting cells (APCs). Because of the difficulty in obtaining these cells directly from tissues, different sources of DCs are frequently used for in vitro experimentation and many of their biological and functional characteristics were studied using these systems. Until recently, it was assumed that specific culture conditions polarized the diffe ...
- DOI:
- 10.1016/j.vetimm.2021.110215
-
https://dx.doi.org/10.1016/j.vetimm.2021.110215
- Author:
- Cascio, Matthew J.; Whitley, Elizabeth M.; Sahay, Bikash; Cortes-Hinojosa, Galaxia; Chang, Lung-Ji; Cowart, Jonathan; Salute, Marc; Sayour, Elias; Dark, Michael; Sandoval, Zachary; Mitchell, Duane A.; Milner, Rowan J.
- Source:
- Veterinary immunology and immunopathology 2021 v.232 pp. 110169
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; T-lymphocytes; dogs; humans; immunohistochemistry; ligands; metastasis; osteosarcoma; patients; Show all 9 Subjects
- Abstract:
- ... Immune-targeted therapies are being successfully implemented into cancer clinical practice. In particular checkpoint inhibitors are employed to modulate the immune microenvironment of solid tumors. We sought to determine the expression of PD-L1, HVEM, and B7H3 in human and canine osteosarcoma, and correlate expression with clinical features and tumor infiltrating lymphocytes in naturally-occurring ...
- DOI:
- 10.1016/j.vetimm.2020.110169
-
https://dx.doi.org/10.1016/j.vetimm.2020.110169
- Author:
- Kalfaoglu, Bahire; Almeida-Santos, José; Tye, Chanidapa Adele; Satou, Yorifumi; Ono, Masahiro
- Source:
- Biochemical and biophysical research communications 2021 v.538 pp. 204-210
- ISSN:
- 0006-291X
- Subject:
- immunopathology, etc ; COVID-19 infection; cytotoxicity; disease severity; immunity; research; Show all 6 Subjects
- Abstract:
- ... T-cells play key roles in immunity to COVID-19 as well as the development of severe disease. T-cell immunity to COVID-19 is mediated through differentiated CD4⁺ T-cells and cytotoxic CD8⁺ T-cells, although their differentiation is often atypical and ambiguous in COVID-19 and single cell dynamics of key genes need to be characterized. Notably, T-cells are dysregulated in severe COVID-19 patients, a ...
- DOI:
- 10.1016/j.bbrc.2020.10.079
-
https://dx.doi.org/10.1016/j.bbrc.2020.10.079
- Author:
- Snyder, Kristin M.; McAloney, Camille A.; Montel, Joshua S.; Modiano, Jaime F.; Walcheck, Bruce
- Source:
- Veterinary immunology and immunopathology 2021 v.231 pp. 110162
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; ; adhesion; dogs; humans; inflammation; metalloproteinases; neutrophils; therapeutics; Show all 9 Subjects
- Abstract:
- ... ADAM17 is a transmembrane protease expressed by most cells in humans and mice that cleaves cell surface substrates primarily in a cis manner, a process referred to as ectodomain shedding. ADAM17 has numerous substrates and plays a broad role in various physiological processes, including as a key regulator of inflammation. At this time, little is known about ADAM17 expression and function in dogs. ...
- DOI:
- 10.1016/j.vetimm.2020.110162
-
https://dx.doi.org/10.1016/j.vetimm.2020.110162
- Author:
- Whiting-Fawcett, Flora; Field, Kenneth A; Puechmaille, Sébastien J; Blomberg, Anna S; Lilley, Thomas M
- Source:
- Current opinion in microbiology 2021 v.62 pp. 61-67
- ISSN:
- 1369-5274
- Subject:
- immunopathology, etc ; Chiroptera; Pseudogymnoascus destructans; disease severity; energy; hibernation; inflammation; innate immunity; neutrophils; psychrophilic fungi; Show all 10 Subjects
- Abstract:
- ... Hibernation, a period where bats have suppressed immunity and low body temperatures, provides the psychrophilic fungus Pseudogymnoascus destructans the opportunity to colonise bat skin, leading to severe disease in susceptible species. Innate immunity, which requires less energy and may remain more active during torpor, can control infections with local inflammation in some bat species that are re ...
- DOI:
- 10.1016/j.mib.2021.05.002
-
https://dx.doi.org/10.1016/j.mib.2021.05.002
- Author:
- Salvador, Coral; Cortes, Aneg L.; Pandiri, Arun R.; Gimeno, Isabel M.
- Source:
- Veterinary immunology and immunopathology 2021 v.237 pp. 110277
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; brain; chickens; eyes; interleukin-15; interleukin-18; interleukin-8; nervous system diseases; paralysis; pathogenesis; virulence; Show all 11 Subjects
- Abstract:
- ... Cytokine transcripts were evaluated chronologically in the brain and in the eye of chickens infected with the very virulent plus Marek’s disease virus (vv + MDV) strain 648A. Brain and eye samples were collected from chickens that were either suffering from transient paralysis (TP) (11 days post inoculation, dpi) or had completely recovered from TP but started developing clinical signs of persiste ...
- DOI:
- 10.1016/j.vetimm.2021.110277
-
https://dx.doi.org/10.1016/j.vetimm.2021.110277
- Author:
- Swain, Trevon; Deaver, Christine M.; Lewandowski, Anne; Myers, Michael J.
- Source:
- Veterinary immunology and immunopathology 2021 v.237 pp. 110267
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; Escherichia coli; biomarkers; body weight; endotoxemia; immunology; inflammation; lipopolysaccharides; microRNA; quantitative polymerase chain reaction; swine; Show all 11 Subjects
- Abstract:
- ... In veterinary medicine, inflammation in swine is evaluated principally by clinical signs. This method is often unreliable when assessing large animal populations because of inconsistent interpretations of clinical observations. This study examined whether changes in miRNA expression can predict the severity of the inflammatory response in swine after administration of Escherichia coli lipopolysacc ...
- DOI:
- 10.1016/j.vetimm.2021.110267
-
https://dx.doi.org/10.1016/j.vetimm.2021.110267
- Author:
- Taylor, Sandra D.; Ivester, Kathleen M.; Stewart, Craig; Page, Allen E.; Horohov, David W.; Couetil, Laurent L.
- Source:
- Veterinary immunology and immunopathology 2021 v.237 pp. 110266
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; asthma; exercise; gene expression; inflammation; interleukin-8; mast cells; neutrophils; observational studies; pathogenesis; Show all 10 Subjects
- Abstract:
- ... Immunological mechanisms involved in the pathogenesis of mild to moderate equine asthma (MEA) are not completely understood. There are limited data on bronchoalveolar lavage fluid (BALF) and blood inflammatory cytokine profiles in racehorses with MEA, and the effect of racing on inflammatory cytokines is unknown.We hypothesized that inflammatory cytokine gene expression in BALF and resting blood w ...
- DOI:
- 10.1016/j.vetimm.2021.110266
-
https://dx.doi.org/10.1016/j.vetimm.2021.110266
- Author:
- Muleme, Michael; Devlin, Joanne M.; Campbell, Angus; Vincent, Gemma; Benham, Paul John; Sprohnle, Cleide; Stent, Andrew; Cameron, Alexander; Islam, Aminul; Graves, Stephen; Wilks, Colin; Stenos, John; Firestone, Simon M.
- Source:
- Veterinary immunology and immunopathology 2021 v.236 pp. 110253
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; Coxiella burnetii; Q fever; colostrum; disease susceptibility; immunogenicity; randomized clinical trials; vaccination; vaccines; Show all 9 Subjects
- Abstract:
- ... Coxiella burnetii causes Q fever in individuals exposed to infected ruminants. Vaccination in 3−4-month-old goats, has been reported to result in significantly greater reduction in C. burnetii shedding compared to goats vaccinated one month before breeding, the most commonly used strategy of controlling Q fever on infected intensively-managed herds. It is possible that an even greater reduction in ...
- DOI:
- 10.1016/j.vetimm.2021.110253
-
https://dx.doi.org/10.1016/j.vetimm.2021.110253
- Author:
- Garchow, Barry; Maque Acosta, Yvan; Kiriakidou, Marianthi
- Source:
- Molecular immunology 2021 v.133 pp. 128-134
- ISSN:
- 0161-5890
- Subject:
- immunopathology, etc ; T-lymphocytes; humans; hypoxia; immunology; lupus erythematosus; metabolism; microRNA; transcription (genetics); transcriptional activation; Show all 10 Subjects
- Abstract:
- ... Systemic lupus erythematosus (SLE, lupus) is a chronic autoimmune disease characterized by loss of peripheral tolerance to nuclear self-antigens. It is increasingly recognized that aberrant T cell metabolism is a critical mediator of SLE immunopathology. Hypoxia inducible factor 1⍺ (HIF-1α) is a key transcription factor that regulates T cell metabolism in response to immune stimuli. T cell activat ...
- DOI:
- 10.1016/j.molimm.2021.02.019
-
https://dx.doi.org/10.1016/j.molimm.2021.02.019
- Author:
- Malinczak, Carrie-Anne; Schuler, Charles F.; Duran, Angela J.; Rasky, Andrew J.; Mire, Mohamed M.; Núñez, Gabriel; Lukacs, Nicholas W.; Fonseca, Wendy
- Source:
- Viruses 2021 v.13 no.4
- ISSN:
- 1999-4915
- Subject:
- immunopathology, etc ; ; Respiratory syncytial virus; adults; asthma; childhood; disease severity; lungs; mice; risk; therapeutics; viruses; Show all 12 Subjects
- Abstract:
- ... Respiratory syncytial virus (RSV) infects most infants by two years of age. It can cause severe disease leading to an increased risk of developing asthma later in life. Previously, our group has shown that RSV infection in mice and infants promotes IL-1β production. Here, we characterized the role of NLRP3-Inflammasome activation during RSV infection in adult mice and neonates. We observed that th ...
- DOI:
- 10.3390/v13040692
-
http://dx.doi.org/10.3390/v13040692
- Author:
- Ludwig, L.; Tsukui, T.; Kageyama, M.; Farias, M.
- Source:
- Veterinary immunology and immunopathology 2021 v.234 pp. 110199
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; Dermatophagoides farinae; allergens; atopic dermatitis; blood serum; dust; fabrics; furniture; hospitals; immunotherapy; Brazil; Show all 11 Subjects
- Abstract:
- ... Atopic dermatitis is associated with the production of IgE antibodies against environmental allergens and allergens of the house dust miteDermatophagoides farinae are frequently implicated in the disease.We aimed to observe the allergen-specific IgE against crudeD. farinae, Der f 2 and Zen 1 in dogs with atopic dermatitis and report if these dogs are in contact with material that could shelter mit ...
- DOI:
- 10.1016/j.vetimm.2021.110199
-
https://dx.doi.org/10.1016/j.vetimm.2021.110199
- Author:
- Roccabianca, Paola; Turchetto, Sara; Ferrari, Nicola; Romeo, Claudia; Bonacini, Serena; Mortellaro, Carlo Maria; Godizzi, Francesco; Tecilla, Marco
- Source:
- Veterinary immunology and immunopathology 2021 v.234 pp. 110193
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; angiogenesis; cats; cell membranes; females; fibrosis; immunohistochemistry; inflammation; mucins; neutrophils; pathogenesis; rhinitis; serology; Show all 13 Subjects
- Abstract:
- ... Feline lymphoplasmacytic rhinitis (FLPCR) is a rare disease with an unclear pathogenesis characterized by lymphoplasmacytic (LPC) inflammation and progressive tissue destruction. Aims were to evaluate specific FLPCR clinical and pathological features to gain insights into disease pathogenesis. Signalment, clinical signs, serology and 47 pin. h biopsies were retrospectively collected from 33 FLPCR ...
- DOI:
- 10.1016/j.vetimm.2021.110193
-
https://dx.doi.org/10.1016/j.vetimm.2021.110193
- Author:
- Hau, Samantha J.; Eberle, Kirsten C.; Brockmeier, Susan L.
- Source:
- Veterinary immunology and immunopathology 2021 v.234 pp. 110205
- ISSN:
- 0165-2427
- Subject:
- immunopathology, etc ; Haemophilus; antibodies; antibody specificity; complement; microorganisms; polysaccharides; pork industry; serotypes; subunit vaccines; vaccine development; Show all 11 Subjects
- Abstract:
- ... Glaesserella (Haemophilus) parasuis is a part of the microbiota of healthy pigs and also causes the systemic condition called Glässer’s disease. G. parasuis is categorized by it capsular polysaccharide into 15 serovars. Because of the serovar and strain specific immunity generated by whole cell vaccines and the rapid onset of disease, G. parasuis has been difficult to control in the swine industry ...
- DOI:
- 10.1016/j.vetimm.2021.110205
-
https://dx.doi.org/10.1016/j.vetimm.2021.110205
