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1. A mixed methods study of stakeholders’ practices and attitudes on avian influenza H7N9 vaccination for the yellow broiler industry in Guangxi, China

Author:
Hao Tang; Chaojian Shen; Lianbin Zou; Chang Cai; Youming Wang; Ian D. Robertson; John Edwards; Baoxu Huang; Mieghan Bruce
Source:
Transboundary and emerging diseases 2022 v.69 no.4 pp. e224
ISSN:
1865-1674
Subject:
inactivated vaccines,   etc   ; avian influenza; chicken industry; humans; stakeholders; vaccination; China;     Show all 7 Subjects
Abstract:
... In response to a sudden increase in H7N9 human infections, China introduced an H5/H7 bivalent inactivated vaccine for poultry in Guangxi and Guangdong provinces in July 2017, which subsequently became integrated into the existing compulsory national H5N1 vaccination programme from September 2017. Although the vaccination programme effectively reduced H7N9 infections in humans and poultry, there ar ...
DOI:
10.1111/tbed.14286

2. Steep Decline in Binding Capability of SARS-CoV-2 Omicron Variant (B.1.1.529) RBD to the Antibodies in Early COVID-19 Convalescent Sera and Inactivated Vaccine Sera

Author:
Wenhao Zhou; Ping He; Junhua Li; Huan Liu; Mengjuan Shi; Junping Yu; Hongping Wei
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
inactivated vaccines,   etc   ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2;     Show all 3 Subjects
Abstract:
... A new SARS-CoV-2 variant B.1.1.529 was named by the WHO as Omicron and classified as a Variant of Concern (VOC) on 26 November 2021. Because this variant has more than 50 mutations, including 30 mutations on the spike, it has generated a lot of concerns on the potential impacts of the VOC on COVID-19. Here through ELISA assays using the recombinant RBD proteins with sequences the same to that of S ...
DOI:
10.3390/v14020335

3. The Swine Erysipelas Vaccine SER-ME Effectively Protects Pigs against Challenge with the Erysipelothrix rhusiopathiae M203/I257 SpaA-Type Variant

Author:
Misako Morimoto; Atsushi Kato; Kotoe Nogami; Yuta Akaike; Takaaki Furusawa; Hiroe Kojima; Chihiro Sasakawa
Source:
Veterinary sciences 2022 v.9 no.8 pp. -
ISSN:
2306-7381
Subject:
inactivated vaccines,   etc   ; Erysipelothrix rhusiopathiae; Japan; antigens; isoleucine; methionine; serotypes; swine erysipelas;     Show all 8 Subjects
Abstract:
... Erysipelothrix rhusiopathiae causes swine erysipelas (SE). Sporadic SE outbreaks in Japan are mostly caused by the E. rhusiopathiae serovar 1a variant featured by methionine (M) and isoleucine (I) at amino acid positions 203 and 257 of the surface protective antigen (Spa) A protein (M203/I257 SpaA-type). To determine if current vaccines are effective against infection with this variant in pigs, on ...
DOI:
10.3390/vetsci9080382

4. Development and immunogenicity evaluation of porcine deltacoronavirus inactivated vaccine with different adjuvants in mice

Author:
Fu-jie Zhao; Lin-tao Liu; Zi Wang; Nian-xiang Wang; Meng-yao Ma; Xin-hao Jia; Si-jia Lu; Yu-qiang Xiang; Lan-lan Zheng; Hui Hu
Source:
Vaccine 2022 v.40 no.31 pp. 4211-4219
ISSN:
0264-410X
Subject:
inactivated vaccines,   etc   ; Porcine deltacoronaviruses; blood serum; diarrhea; histopathology; immunogenicity; interleukin-4; ligands; vaccination;     Show all 9 Subjects
Abstract:
... Porcine deltacoronavirus (PDCoV) is a novel coronavirus that causes diarrhea in pigs of various ages, especially in suckling piglets, and there are no effective measures to prevent and control PDCoV currently. In this study, two adjuvants Al(OH)₃ and ODN2395 working through different mechanisms were used to prepare inactivated PDCoV vaccines, and the immune effects of PDCoV inactivated vaccines we ...
DOI:
10.1016/j.vaccine.2022.05.085

5. Previous Infection with SARS-CoV-2 Correlates with Increased Protective Humoral Responses after a Single Dose of an Inactivated COVID-19 Vaccine

Author:
Flávia F. Bagno; Luis A. F. Andrade; Sarah A. R. Sérgio; Pierina L. Parise; Daniel A. Toledo-Teixeira; Ricardo T. Gazzinelli; Ana P. S. M. Fernandes; Santuza M. R. Teixeira; Fabiana Granja; José L. Proença-Módena; Flavio G. da Fonseca
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
inactivated vaccines,   etc   ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antibodies; vaccination;     Show all 5 Subjects
Abstract:
... Previous studies have indicated that antibody responses can be robustly induced after the vaccination in individuals previously infected by SARS-CoV-2. To evaluate anti-SARS-CoV-2 humoral responses in vaccinated individuals with or without a previous history of COVID-19, we compared levels of anti-SARS-CoV-2 antibodies in the sera from 21 vaccinees, including COVID-19-recovered or -naïve individua ...
DOI:
10.3390/v14030510

6. Heterologous prime-boost vaccination programs against Newcastle disease virus genotype VII in chickens

Author:
M.E. Sedeik; A.M. Awad; N.A. El-Shall
Source:
Comparative immunology, microbiology, and infectious diseases 2022 v.87 pp. 101836
ISSN:
0147-9571
Subject:
inactivated vaccines,   etc   ; Avian orthoavulavirus 1; chickens; genotype; hatcheries; immunology; microbiology; mortality; vaccination; weight gain;     Show all 10 Subjects
Abstract:
... The effectiveness of two vectored ND vaccines (Innovax® ND and Vectormune® ND) was tested, in single and prime-boost vaccination programs, against challenge with velogenic NDV genotype VII, in eight chicken groups (G). G1 and G2 were control groups. G3–5 received Innovax® ND, while G6–8 received Vectormune® ND on the hatchery. Additionally, G4 and G7 received live La Sota two-weeks later, and G5 a ...
DOI:
10.1016/j.cimid.2022.101836

7. Immune responses to Vibrio vulnificus formalin‐killed vaccine and ghost vaccine in Scophthalmus maximus

Author:
Shun Zhou; Ying Li; Jingyuan Yi; Xujia Zheng; Qing Huang; Lin Su; Baoshan Guo; Zongrui Yang; Yunji Xiu
Source:
Journal of fish diseases 2022 v.45 no.10 pp. 1511-1527
ISSN:
0140-7775
Subject:
inactivated vaccines,   etc   ; Scophthalmus maximus; Vibrio vulnificus; antibodies; autoimmunity; fish; immune response; transcriptome; vaccination; vibriosis;     Show all 10 Subjects
Abstract:
... In this research, Vibrio vulnificus formalin‐killed (FKCs) vaccine and ghost (VVGs) vaccine were successfully developed, and shown to prevent vibriosis of Scophthalmus maximus resulting from V. vulnificus. The antibody titre of FKCs and VVGs vaccine was 1: 2⁸ and 1: 2¹¹. The RPS of FKCs and VVGs vaccine was 60% and 80%. In order to improve the understanding of vaccine protection mechanism, transcr ...
DOI:
10.1111/jfd.13678

8. TbpBY167A-Based Vaccine Can Protect Pigs against Glässer’s Disease Triggered by Glaesserella parasuis SV7 Expressing TbpB Cluster I

Author:
Simone Ramos Prigol; Rafaela Klein; Somshukla Chaudhuri; Gabriela Paraboni Frandoloso; João Antônio Guizzo; César Bernardo Gutiérrez Martín; Anthony Bernard Schryvers; Luiz Carlos Kreutz; Rafael Frandoloso
Source:
Pathogens 2022 v.11 no.7 pp. -
ISSN:
2076-0817
Subject:
inactivated vaccines,   etc   ; amino acid sequences; antibody formation; antigenic variation; cross immunity; epitopes; phylogeny; serotypes; swine; virulence;     Show all 10 Subjects
Abstract:
... Glaesserella parasuis is the etiological agent of Glässer’s disease (GD), one of the most important diseases afflicting pigs in the nursery phase. We analyzed the genetic and immunological properties of the TbpB protein naturally expressed by 27 different clinical isolates of G. parasuis that were typed as serovar 7 and isolated from pigs suffering from GD. All the strains were classified as virul ...
DOI:
10.3390/pathogens11070766

9. Comparative proteomic analysis of Leptospira interrogans serogroup Icterohaemorrhagiae human vaccine strain and epidemic isolate from China

Author:
Zhe Li; Ying Zhang; Zhongli Du; Xiaofang Xin; Qiang Ye; Yinghua Xu
Source:
Archives of microbiology 2022 v.204 no.8 pp. 460
ISSN:
0302-8933
Subject:
inactivated vaccines,   etc   ; Leptospira interrogans; amino acids; carbohydrates; energy metabolism; humans; leptospirosis; microbiology; pathogens; prediction; proteomics; serotypes; China;     Show all 13 Subjects
Abstract:
... Leptospira interrogans serogroup Icterohaemorrhagiae is the predominant pathogen causing leptospirosis in China and is still used as the vaccine strain for the current human inactivated vaccine. Unlike the clade ST17, which is distributed worldwide, ST1 is the most prevalent in serogroup Icterohaemorrhagiae in China. To further characterize leptospiral pathogens, isobaric tags for relative and abs ...
DOI:
10.1007/s00203-022-02987-7

10. Development and validation of a DIVA ELISA for differentiating BEFV infected from vaccinated animals

Author:
Chenxiang He; Shandian Gao; Junzheng Du; Zhancheng Tian; Guiquan Guan; Hong Yin
Source:
Journal of virological methods 2022 v.310 pp. 114625
ISSN:
0166-0934
Subject:
inactivated vaccines,   etc   ; Escherichia coli; absorbance; antibodies; bovine ephemeral fever; cattle; cross reaction; diagnostic techniques; seroprevalence; surveys; China;     Show all 11 Subjects
Abstract:
... Inactivated vaccine is considered safe and used for prevention of bovine ephemeral fever in several endemic countries. To differentiate between BEFV-infected and vaccinated animals, we developed an ELISA capable of detecting infection-related antibodies against BEFV. Recombinant proteins, including N, P, M, L, GNS, α2, β and γ, were expressed in E. coli and screened by Western blotting and ELISA. ...
DOI:
10.1016/j.jviromet.2022.114625

11. Development of an indirect competitive enzyme linked immunosorbent assay for the quantitative detection of Mycoplasma hyopneumoniae during the vaccine production process

Author:
Yanna Wei; Thandeka Khoza; Yanfei Yu; Li Wang; Beibei Liu; Jia Wang; Lanxi Gan; Fei Hao; Guoqing Shao; Zhixin Feng; Qiyan Xiong
Source:
Journal of immunological methods 2022 v.500 pp. 113196
ISSN:
0022-1759
Subject:
inactivated vaccines,   etc   ; Mycoplasma hyopneumoniae; antigens; color; enzymes; equations; live vaccines; peptide elongation factors; polyclonal antibodies; regression analysis;     Show all 10 Subjects
Abstract:
... Inactivated Mycoplasma hyopneumoniae vaccine is used extensively to control M. hyopneumoniae infection worldwide. Quantification techniques are essential in the process of standardizing and validating vaccines. In this study, we developed and optimized an indirect competitive enzyme linked immunosorbent assay (ic-ELISA) for the rapid quantification of M. hyopneumoniae antigen during vaccine produc ...
DOI:
10.1016/j.jim.2021.113196

12. A pigeon paramyxovirus type 1 isolated from racing pigeon as an inactivated vaccine candidate provides effective protection

Author:
Yajie Zhang; Weifan Wang; Yongkun Li; Jinming Liu; Wenbin Wang; Jun Bai; Zengqi Yang; Haijin Liu; Sa Xiao
Source:
Poultry science 2022 v.101 no.10 pp. 102097
ISSN:
0032-5791
Subject:
inactivated vaccines,   etc   ; Avian orthoavulavirus 1; Newcastle disease; antibodies; cross reaction; genetic distance; genome; mortality; phylogeny; subgenotype; virulence; China;     Show all 12 Subjects
Abstract:
... Pigeon paramyxovirus type 1 (PPMV-1), a variant of Newcastle disease virus (NDV), causes severe Newcastle disease (ND) in pigeons. However, there is no PPMV-1 vaccine available worldwide. In this study, a strain of PPMV-1 was isolated from outbreaks in a vaccinated racing pigeon (Columbia livia) loft in China, namely, PPMV-1/pigeon/Gansu/China/02/2020 (GS02). Experimental infection with GS02 showe ...
DOI:
10.1016/j.psj.2022.102097

13. Sequential immunization with SARS-CoV-2 RBD vaccine induces potent and broad neutralization against variants in mice

Author:
Shuo Song; Bing Zhou; Lin Cheng; Weilong Liu; Qing Fan; Xiangyang Ge; Hua Peng; Yang-Xin Fu; Bin Ju; Zheng Zhang
Source:
Virology journal 2022 v.19 no.1 pp. 2
ISSN:
1743-422X
Subject:
inactivated vaccines,   etc   ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; mutants; neutralization; public health; secondary immunization; virology;     Show all 8 Subjects
Abstract:
... The current COVID-19 pandemic caused by constantly emerging SARS-CoV-2 variants still poses a threat to public health worldwide. Effective next-generation vaccines and optimized booster vaccination strategies are urgently needed. Here, we sequentially immunized mice with a SARS-CoV-2 wild-type inactivated vaccine and a heterologous mutant RBD vaccine, and then evaluated their neutralizing antibody ...
DOI:
10.1186/s12985-021-01737-3

14. Sequentially immune‐induced antibodies could cross‐neutralize SARS‐CoV‐2 variants

Author:
Qi Lv; Shasha Zhou; Feifei Qi; Yaqing Zhang; Fengdi Li; Mingya Liu; Linlin Bao
Source:
Animal models and experimental medicine 2022 v.5 no.1 pp. 89-93
ISSN:
2576-2095
Subject:
inactivated vaccines,   etc   ; Severe acute respiratory syndrome coronavirus 2; antibodies; humans; humoral immunity; medicine; monkeys; neutralization; recombinant proteins; vaccination;     Show all 10 Subjects
Abstract:
... BACKGROUND: The Omicron (B.1.1.529) SARS‐COV‐2 variant has raised serious concerns because of its unprecedented rapid rate of spreading and the fact that there are 36 mutations in the spike protein. Since the vaccine‐induced neutralizing antibody targets are the spike protein, this may lead to the possibility of vaccine‐induced humoral immunity escape. METHODS: We measured the neutralizing activit ...
DOI:
10.1002/ame2.12216

15. An inactivated vaccine against infectious pancreatic necrosis virus in rainbow trout (Oncorhynchus mykiss)

Author:
Kaiyue Duan; Xin Tang; Jingzhuang Zhao; Guangming Ren; Yizhi Shao; Tongyan Lu; Baoquan He; Liming Xu
Source:
Fish & shellfish immunology 2022 v.127 pp. 48-55
ISSN:
1050-4648
Subject:
inactivated vaccines,   etc   ; Infectious pancreatic necrosis virus; Oncorhynchus mykiss; ambient temperature; antiviral properties; financial economics; fish; immune response; industry; shellfish;     Show all 10 Subjects
Abstract:
... Infectious pancreatic necrosis virus (IPNV), belonging to the genus Aquabirnavirus within the family Birnaviridae, causes huge economic loss to the global salmonid industry every year. Recently, outbreaks of disease caused by genogroup I IPNV were found in many rainbow trout (Oncorhynchus mykiss) farms worldwide. An inactivated vaccine was prepared using a genogroup I IPNV isolate with an optimize ...
DOI:
10.1016/j.fsi.2022.06.008

16. Mucosal immune responses and protective efficacy in yellow catfish after immersion vaccination with bivalent inactivated Aeromonas veronii and Edwardsiella ictaluri vaccine

Author:
Wei Guang Kong; Da Cheng Qin; Qing Jiang Mu; Zhao Ran Dong; Yang Zhi Luo; Tao Shan Ai; Zhen Xu
Source:
Water biology and security 2022 v.1 no.2 pp. 100032
ISSN:
2772-7351
Subject:
inactivated vaccines,   etc   ; Aeromonas veronii; Edwardsiella ictaluri; Tachysurus fulvidraco; agglutination; antibodies; farmed fish; kidneys; models; mucosal immunity; spleen; vaccination; virulence; water;     Show all 14 Subjects
Abstract:
... Mucosal vaccination, which has the potential to induce both mucosal and systemic immune responses, is considered the most suitable method of preventing infectious diseases in farmed fish. Aeromonas veronii and Edwardsiella ictaluri are two pathogenic bacteria found in yellow catfish and often infect the fish through mucosal surfaces. Delivery of a bivalent inactivated vaccine by injection has been ...
DOI:
10.1016/j.watbs.2022.100032

17. Assessment of fitness of foot‐and‐mouth disease virus A IND 27/2011 as candidate vaccine strain

Author:
Sreenivasa Beeragere Parameshwaraiah; Jajati K. Mohapatra; Veena Jumanal; Dhanesh Valia Valappil; Saravanan Subramaniam; Bhimnere Hanumanthagouda Manjunatha Patel; Suresh H. Basagoudanavar; Madhusudan Hosamani; Brahmadev Pattnaik; Raj Kumar Singh; Aniket Sanyal
Source:
Transboundary and emerging diseases 2022 v.69 no.5 pp. 2996-3000
ISSN:
1865-1674
Subject:
inactivated vaccines,   etc   ; Foot-and-mouth disease virus; amino acids; antigenic variation; capsid; cattle; cell lines; immunogenicity; nucleotide sequences; serotypes; viruses; India;     Show all 12 Subjects
Abstract:
... Antigenic profiling of recent field outbreak strains of foot‐and‐mouth disease virus (FMDV) serotype A in India has revealed considerable antigenic drift from the vaccine strain, A IND 40/2000, necessitating the selection of a new strain. The complete genome sequence of A IND 27/2011 was analysed. Vaccine quality attributes of the new candidate strain including potency as an inactivated vaccine in ...
DOI:
10.1111/tbed.14166

18. Protective cellular and humoral immune responses to Edwardsiella tarda in flounder (Paralichthys olivaceus) immunized by an inactivated vaccine

Author:
Xiaoyan Wu; Jing Xing; Xiaoqian Tang; Xiuzhen Sheng; Heng Chi; Wenbin Zhan
Source:
Molecular immunology 2022 v.149 pp. 77-86
ISSN:
0161-5890
Subject:
inactivated vaccines,   etc   ; Edwardsiella tarda; Paralichthys olivaceus; acid phosphatase; alkaline phosphatase; flounder; histopathology; kidneys; lysozyme; microbial load; spleen; superoxide dismutase; transcription (genetics);     Show all 13 Subjects
Abstract:
... Protection is crucial for a vaccine. In this study, flounder was inoculated with an inactivated Edwardsiella tarda for 5 weeks then challenged with E. tarda, after that, the protective cellular and humoral immune responses were studied using specific antibodies against CD4, CD8 and IgM, respectively, previously produced in our lab. And then gene transcription, relative percent survival (RPS), inna ...
DOI:
10.1016/j.molimm.2022.06.008

19. Protective efficacy of a reverse genetics-derived inactivated vaccine against equine influenza virus in horses

Author:
Minoru Ohta; Yoshinori Kambayashi; Hiroshi Mita; Taisuke Kuroda; Hiroshi Bannai; Koji Tsujimura; Takashi Yamanaka; Marie Garvey; Ann Cullinane; Seiya Yamayoshi; Yoshihiro Kawaoka; Manabu Nemoto
Source:
Vaccine 2022 pp. -
ISSN:
0264-410X
Subject:
inactivated vaccines,   etc   ; Influenza A virus; amyloid; blood serum; equine influenza; fever; formalin; hemagglutinins; horses; influenza vaccines; reverse genetics; sialidase; vaccination; viruses;     Show all 14 Subjects
Abstract:
... Updating vaccine strains is essential to control equine influenza. We evaluated the protective efficacy of an inactivated equine influenza vaccine derived from viruses generated by reverse genetics (RG) in horses in an experimental viral challenge study. Wild-type (WT) virus (A/equine/Tipperary/1/2019) and virus generated by RG (consisting of hemagglutinin and neuraminidase genes from A/equine/Tip ...
DOI:
10.1016/j.vaccine.2022.09.047

20. Supplementing young cattle with a rumen-protected grape extract around vaccination increases humoral response and antioxidant defenses

Author:
Paul Engler; Clémence Desguerets; Mohamed El Amine Benarbia; Yassine Mallem
Source:
Veterinary and Animal Science 2022 v.15 pp. 100232
ISSN:
2451-943X
Subject:
inactivated vaccines,   etc   ; antibodies; antibody formation; antioxidant activity; antioxidants; biosecurity; blood; cows; dairy farming; disease prevention; farmers; grapes; humoral immunity; oxidative stress; polyphenols; seroprevalence; vaccination;     Show all 17 Subjects
Abstract:
... Vaccination is an important mainstay of biosecurity and disease prevention in livestock farming. Vaccination failures represent an economic burden for the farmer. Polyphenol supplementation, known for its antioxidant properties, could help reduce oxidative damage and improve the success of vaccination. We evaluated the effect of a rumen-protected grape extract (RPGE) supplementation around vaccina ...
DOI:
10.1016/j.vas.2022.100232