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1. Ancillary benefits of seasonal influenza vaccination in middle-income countries

Author:
Ebama, Malembe S.; Chu, Susan Y.; Azziz-Baumgartner, Eduardo; Lafond, Kathryn E.; McCarron, Margaret; Hadler, Stephen C.; Porter, Rachael M.; McKinlay, Mark; Bresee, Joseph
Source:
Vaccine 2021 v.39 no.14 pp. 1892-1896
ISSN:
0264-410X
Subject:
influenza; influenza vaccination; influenza vaccines,   etc   ; COVID-19 infection; risk;     Show all 5 Subjects
Abstract:
... While seasonal influenza vaccines (SIV) remain the best method to prevent influenza-associated illnesses, implementing SIV programs may benefit countries beyond disease reduction, strengthening health systems and national immunization programs, or conversely, introduce new challenges. Few studies have examined perceived impacts of SIV introduction beyond disease reduction on health systems; unders ...
DOI:
10.1016/j.vaccine.2021.02.048

2. A validated modification of the vaccine hesitancy scale for childhood, influenza and HPV vaccines

Author:
Helmkamp, Laura J.; Szilagyi, Peter G.; Zimet, Gregory; Saville, Alison W.; Gurfinkel, Dennis; Albertin, Christina; Breck, Abigail; Vangala, Sitaram; Kempe, Allison
Source:
Vaccine 2021 v.39 no.13 pp. 1831-1839
ISSN:
0264-410X
Subject:
influenza; influenza vaccines,   etc   ; childhood; children; factor analysis;     Show all 5 Subjects
Abstract:
... Vaccine hesitancy contributes to outbreaks of preventable disease worldwide. The Vaccine Hesitancy Scale (VHS), developed by the international WHO SAGE Working Group, has been validated previously for measuring hesitancy towards childhood vaccines; some psychometric properties were suboptimal.We collected data using large, nationally-representative samples of parents in the U.S. We adapted the VHS ...
DOI:
10.1016/j.vaccine.2021.02.039

3. Introductory paper: High-dose influenza vaccine

Author:
Diaco, Mia; Chang, Lee-Jah; Seet, Bruce; Robertson, Corey A; Chit, Ayman; Mercer, Monica; Greenberg, David P; Hollingsworth, Rosalind; Samson, Sandrine I.
Source:
Vaccine 2021 v.39 pp. A1
ISSN:
0264-410X
Subject:
influenza; influenza vaccines,   etc   ; evolution; public health;     Show all 4 Subjects
Abstract:
... Seasonal influenza has a significant impact on global public health each year, especially in older adults 65 years of age and above. This paper presents the evolution of high-dose influenza vaccine and the quantity as well as quality of evidence on this vaccine. Its introduces other peer-reviewed manuscripts included in this supplement covering the benefits high-dose influenza vaccine over ten con ...
DOI:
10.1016/j.vaccine.2020.09.005

4. Filamentous anti-influenza agents wrapping around viruses

Author:
Chung, Jinhyo; Jung, Younghun; Hong, Caleb; Kim, Subin; Moon, Seokoh; Kwak, Eun A.; Hwang, Beom Jeung; Park, Seong-Hyun; Seong, Baik Lin; Kweon, Dae-Hyuk; Chung, Woo-Jae
Source:
Journal of colloid and interface science 2021 v.583 pp. 267-278
ISSN:
0021-9797
Subject:
Influenza A virus; influenza,   etc   ; dendrimers; ligands;     Show all 4 Subjects
Abstract:
... Owing to the emerging resistance to current anti-influenza therapies, strategies for blocking virus–cell interaction with agents that mimic interactions with host cell receptors are garnering interest. In this context, a multivalent presentation of sialyl groups on various types of scaffold materials such as dendrimers, liposomes, nanoparticles, and natural/synthetic polymers has been investigated ...
DOI:
10.1016/j.jcis.2020.09.012

5. Differences and disparities in seasonal influenza vaccine, acceptance, adverse reactions, and coverage by age, sex, gender, and race

Author:
Kini, Aniket; Morgan, Rosemary; Kuo, Helen; Shea, Patrick; Shapiro, Janna; Leng, Sean X.; Pekosz, Andrew; Klein, Sabra L.
Source:
Vaccine 2021
ISSN:
0264-410X
Subject:
influenza; influenza vaccines,   etc   ; databases; gender; public health;     Show all 5 Subjects
Abstract:
... Influenza is a significant threat to public health worldwide. Despite the widespread availability of effective and generally safe vaccines, the acceptance and coverage of influenza vaccines are significantly lower than recommended. Sociodemographic variables are known to be potential predictors of differential influenza vaccine uptake and outcomes.This review aims to (1) identify how sociodemograp ...
DOI:
10.1016/j.vaccine.2021.04.013

6. One world, one health

Author:
Peiris, Joseph Sriyal Malik
Source:
Cell 2021 v.184 no.8 pp. 1956-1959
ISSN:
0092-8674
Subject:
influenza,   etc   ; Asia; Canada;     Show all 3 Subjects
Abstract:
... The past year has underscored the threat that emerging viruses pose to global health. The 2021 John Dirks Canada Gairdner Global Health award recognizes the contributions of Joseph Sriyal Malik Peiris and Yi Guan toward understanding the origins and options for control of newly emerging infectious disease outbreaks in Asia, notably zoonotic influenza and severe acute respiratory syndrome (SARS). N ...
DOI:
10.1016/j.cell.2021.03.021

7. Sample size considerations for mid-season estimates from a large influenza vaccine effectiveness network in the United States

Author:
Chung, Jessie R.; Flannery, Brendan; Kim, Sara S.; Gaglani, Manjusha; Raiyani, Chandni; Belongia, Edward A.; McLean, Huong Q.; Nowalk, Mary Patricia; Zimmerman, Richard K.; Jackson, Michael L.; Jackson, Lisa A.; Martin, Emily T.; Monto, Arnold S.; Patel, Manish
Source:
Vaccine 2021 v.39 no.25 pp. 3324-3328
ISSN:
0264-410X
Subject:
influenza; influenza vaccines,   etc   ; issues and policy; public health; sample size;     Show all 5 Subjects
Abstract:
... Mid-season influenza vaccine effectiveness (VE) estimates are a useful tool to help guide annual influenza vaccine strain selection, vaccine policy, and public health messaging. We propose using a sample size-driven approach with data-driven inputs for publication of mid-season influenza VE.We used pooled inputs for VE by (sub)type and average vaccine coverage by age groups using data from eight s ...
DOI:
10.1016/j.vaccine.2021.05.004

8. Influenza vaccination among caregivers and household contacts of children with asthma

Author:
Gkentzi, Despoina; Aggelopoulos, Konstantinos; Karatza, Ageliki; Sinopidis, Xenophon; Dimitriou, Gabriel; Fouzas, Sotirios
Source:
Vaccine 2021 v.39 no.17 pp. 2331-2334
ISSN:
0264-410X
Subject:
influenza vaccination; influenza vaccines,   etc   ; asthma; caregivers; factor analysis; questionnaires; surveys;     Show all 7 Subjects
Abstract:
... Data on influenza vaccination status among household contacts of asthmatic children are lacking. Our aim was to assess the influenza vaccination status of parents and caregivers of asthmatic children in the 2018–2019 season as well as to identify reasons for undervaccination. We performed a questionnaire-based survey in parents, caregivers and household contacts of 178 asthmatic children. Only the ...
DOI:
10.1016/j.vaccine.2021.03.042

9. Egyptian Fruit Bats (Rousettus aegyptiacus) Were Resistant to Experimental Inoculation with Avian-Origin Influenza A Virus of Subtype H9N2, But Are Susceptible to Experimental Infection with Bat-Borne H9N2 Virus

Author:
Halwe, Nico Joel; Gorka, Marco; Hoffmann, Bernd; Rissmann, Melanie; Breithaupt, Angele; Schwemmle, Martin; Beer, Martin; Kandeil, Ahmed; Ali, Mohamed A.; Kayali, Ghazi; Hoffmann, Donata; Balkema-Buschmann, Anne
Source:
Viruses 2021 v.13 no.4
ISSN:
1999-4915
Subject:
Influenza A virus; influenza,   etc   ; Rousettus; fruits; laying hens; pathogenesis; seroconversion;     Show all 7 Subjects
Abstract:
... Influenza A viruses (IAV) of subtype H9N2, endemic in world-wide poultry holdings, are reported to cause spill-over infections to pigs and humans and have also contributed substantially to recent reassortment-derived pre-pandemic zoonotic viruses of concern, such as the Asian H7N9 viruses. Recently, a H9N2 bat influenza A virus was found in Egyptian fruit bats (Rousettus aegyptiacus), raising the ...
DOI:
10.3390/v13040672

10. Differential Influence of Age on the Relationship between Genetic Mismatch and A(H1N1)pdm09 Vaccine Effectiveness

Author:
Cao, Lirong; Zhao, Shi; Lou, Jingzhi; Zheng, Hong; Chan, Renee W. Y.; Chong, Marc K. C.; Chen, Zigui; Chan, Paul K. S.; Zee, Benny C. Y.; Wang, Maggie H.
Source:
Viruses 2021 v.13 no.4
ISSN:
1999-4915
Subject:
influenza; influenza vaccines,   etc   ; amino acids; elderly; hemagglutinins; mutation; sialidase; vaccination;     Show all 8 Subjects
Abstract:
... Assessment of influenza vaccine effectiveness (VE) and identification of relevant influencing factors are the current priorities for optimizing vaccines to reduce the impacts of influenza. To date, how the difference between epidemic strains and vaccine strains at genetic scale affects age-specific vaccine performance remains ambiguous. This study investigated the association between genetic misma ...
DOI:
10.3390/v13040619

11. Effectiveness of influenza vaccination in infants and toddlers with and without prior infection history: The Japan Environment and Children’s Study

Author:
Yokomichi, Hiroshi; Kojima, Reiji; Horiuchi, Sayaka; Ooka, Tadao; Akiyama, Yuka; Miyake, Kunio; Mochizuki, Mie; Otawa, Sanae; Shinohara, Ryoji; Yamagata, Zentaro
Source:
Vaccine 2021 v.39 no.13 pp. 1800-1804
ISSN:
0264-410X
Subject:
influenza; influenza vaccination,   etc   ; Japan; preschools; relative risk; risk reduction; vaccines;     Show all 7 Subjects
Abstract:
... We calculated the Poisson-regression-adjusted relative risk (RR) of new influenza infection by vaccination, prior infection, and vaccination after prior infection in a large Japanese birth cohort, using data from ≤89,253 children aged 6 months to 3 years. The effectiveness of risk reduction (1 − RR) by vaccination at ages 1.5–3 years was 21%–31%. The RR of new infection after prior infection vs. n ...
DOI:
10.1016/j.vaccine.2021.02.044

12. Comparison of local influenza vaccine effectiveness using two methods

Author:
Balasubramani, G.K.; Zimmerman, Richard K; Eng, Heather; Lyons, Jason; Clarke, Lloyd; Nowalk, Mary Patricia
Source:
Vaccine 2021 v.39 no.8 pp. 1283-1289
ISSN:
0264-410X
Subject:
influenza; influenza vaccines,   etc   ; databases; regression analysis; sample size; vaccination;     Show all 6 Subjects
Abstract:
... In some settings, research methods to determine influenza vaccine effectiveness (VE) may not be appropriate because of cost, time constraints, or other factors. Administrative database analysis of viral testing results and vaccination history may be a viable alternative. This study compared VE estimates from outpatient research and administrative databases.Using the test-negative, case-control des ...
DOI:
10.1016/j.vaccine.2021.01.013

13. Variable seasonal influenza vaccine effectiveness across geographical regions, age groups and levels of vaccine antigenic similarity with circulating virus strains: A systematic review and meta-analysis of the evidence from test-negative design studies after the 2009/10 influenza pandemic

Author:
Okoli, G.N.; Racovitan, F.; Abdulwahid, T.; Righolt, C.H.; Mahmud, S.M.
Source:
Vaccine 2021 v.39 no.8 pp. 1225-1240
ISSN:
0264-410X
Subject:
influenza; influenza vaccines,   etc   ; meta-analysis; pandemic; systematic review; variance; viruses;     Show all 7 Subjects
Abstract:
... We examined the influence of some factors on seasonal influenza vaccine effectiveness (VE) from test-negative design (TND) studies.We systematically searched for full-text publications of VE against laboratory-confirmed influenza from TND studies in outpatient settings after the 2009/10 influenza pandemic. Two reviewers independently selected and extracted data from the included studies. We calcul ...
DOI:
10.1016/j.vaccine.2021.01.032

14. T Cell Immunity against Influenza: The Long Way from Animal Models Towards a Real-Life Universal Flu Vaccine

Author:
Schmidt, Anna; Lapuente, Dennis
Source:
Viruses 2021 v.13 no.2
ISSN:
1999-4915
Subject:
influenza; influenza vaccines,   etc   ; T-lymphocytes; immunity; memory; pandemic; respiratory system;     Show all 7 Subjects
Abstract:
... Current flu vaccines rely on the induction of strain-specific neutralizing antibodies, which leaves the population vulnerable to drifted seasonal or newly emerged pandemic strains. Therefore, universal flu vaccine approaches that induce broad immunity against conserved parts of influenza have top priority in research. Cross-reactive T cell responses, especially tissue-resident memory T cells in th ...
DOI:
10.3390/v13020199

15. Effect of influenza A virus sow vaccination on infection in pigs at weaning: A prospective longitudinal study

Author:
Chamba Pardo, Fabian O.; W. Allerson, Matthew; R. Culhane, Marie; B. Morrison, Robert; R. Davies, Peter; Perez, Andres; Torremorell, Montserrat
Source:
Transboundary and emerging diseases 2021 v.68 no.1 pp. 183-193
ISSN:
1865-1674
Subject:
Influenza A virus; influenza,   etc   ; ; herds; longitudinal studies; nose; swine; vaccination;     Show all 8 Subjects
Abstract:
... Although vaccination is the main measure to control influenza A virus (IAV) in swine, there is limited information on the efficacy of sow vaccination on reducing IAV infections in pigs at weaning. We assessed the effect of sow vaccination on IAV infection in pigs at weaning in a cohort of 52 breeding herds studied prospectively. Herds were voluntarily enrolled according to their IAV history, sow v ...
DOI:
10.1111/tbed.13688

16. Cellular self‐cannibalism helps immune cells fight the flu

Author:
Postoak, Joshua Luke; Yang, Guan; Wu, Lan; Van Kaer, Luc
Source:
TheFEBS journal 2021 v.288 no.10 pp. 3154-3158
ISSN:
1742-464X
Subject:
influenza,   etc   ; Orthomyxoviridae; antigens; autophagy; peptides;     Show all 5 Subjects
Abstract:
... CD4 T cells are critical for generating protective immune responses to infection with influenza virus. Although most CD4 T cells react with peptides from extracellular sources, many react with peptides from viral particles synthesized inside cells; however, the pathways employed for processing the latter antigens remain uncertain. Deng et al. provide evidence for a role of autophagy, a cellular se ...
DOI:
10.1111/febs.15641

17. Flu Universal Vaccines: New Tricks on an Old Virus

Author:
Du, Ruikun; Cui, Qinghua; Rong, Lijun
Source:
Virologica Sinica 2021 v.36 no.1 pp. 13-24
ISSN:
1674-0769
Subject:
influenza,   etc   ; epitopes; vaccine development; viruses;     Show all 4 Subjects
Abstract:
... Conventional influenza vaccines are based on predicting the circulating viruses year by year, conferring limited effectiveness since the antigenicity of vaccine strains does not always match the circulating viruses. This necessitates development of universal influenza vaccines that provide broader and lasting protection against pan-influenza viruses. The discovery of the highly conserved immunogen ...
DOI:
10.1007/s12250-020-00283-6

18. Knowledge and attitude of Kenyan healthcare workers towards pandemic influenza disease and vaccination: 9 years after the last influenza pandemic

Author:
Andayi, Fred; Emukule, Gideon O.; Osoro, Eric; Ndegwa, Linus K.; Otiato, Fredrick; Muturi, Peter; Azziz-Baumgartner, Eduardo; Kalani, Rosalia; Anyango, Edwina; Muthoka, Philip M.; Ebama, Malembe S.; Bresee, Joseph; Chaves, Sandra S
Source:
Vaccine 2021 v.39 no.29 pp. 3991-3996
ISSN:
0264-410X
Subject:
influenza; influenza vaccination; influenza vaccines,   etc   ; health education; health services; pandemic; risk; surveys; Kenya;     Show all 9 Subjects
Abstract:
... Healthcare workers (HCWs) are at high risk of exposure and transmission of infectious respiratory pathogens like influenza. Despite the potential benefits, safety and efficacy of influenza vaccination, vaccines are still underutilized in Africa, including among HCWs.From May-June 2018, we conducted a cross-sectional, self-administered, written survey among HCWs from seven counties in Kenya and ass ...
DOI:
10.1016/j.vaccine.2021.05.057

19. Impact of prior vaccination on antibody response and influenza-like illness among Australian healthcare workers after influenza vaccination in 2016

Author:
Leung, Vivian K.Y.; Fox, Annette; Carolan, Louise A.; Aban, Malet; Laurie, Karen L.; Druce, Julian; Deng, Yi-Mo; Slavin, Monica A.; Marshall, Caroline; Sullivan, Sheena G.
Source:
Vaccine 2021 v.39 no.24 pp. 3270-3278
ISSN:
0264-410X
Subject:
influenza; influenza vaccination; influenza vaccines,   etc   ; antibodies; antibody formation; blood serum; health services; hemagglutination; immunogenicity;     Show all 9 Subjects
Abstract:
... Epidemiological studies suggest that influenza vaccine effectiveness decreases with repeated administration. We examined antibody responses to influenza vaccination among healthcare workers (HCWs) by prior vaccination history and determined the incidence of influenza infection.HCWs were vaccinated with the 2016 Southern Hemisphere quadrivalent influenza vaccine. Serum samples were collected pre-va ...
DOI:
10.1016/j.vaccine.2021.04.036

20. Rapid and Efficient Cell-to-Cell Transmission of Avian Influenza H5N1 Virus in MDCK Cells Is Achieved by Trogocytosis

Author:
Kongsomros, Supasek; Manopwisedjaroen, Suwimon; Chaopreecha, Jarinya; Wang, Sheng-Fan; Borwornpinyo, Suparerk; Thitithanyanont, Arunee
Source:
Pathogens 2021 v.10 no.4
ISSN:
2076-0817
Subject:
Influenza A virus; avian influenza; human influenza,   etc   ; coculture; dogs; epithelium; humans; kidneys; lungs; plasma membrane;     Show all 10 Subjects
Abstract:
... Viruses have developed direct cell-to-cell transfer strategies to enter target cells without being released to escape host immune responses and antiviral treatments. These strategies are more rapid and efficient than transmission through indirect mechanisms of viral infection between cells. Here, we demonstrate that an H5N1 influenza virus can spread via direct cell-to-cell transfer in Madin-Darby ...
DOI:
10.3390/pathogens10040483