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Influenza A virus, etc ; Oriental traditional medicine; Trollius chinensis; Western blotting; blood; cytoplasm; epithelium; fluorescent antibody technique; lungs; nasal cavity; pharmacology; pharyngitis; pneumonia; spleen; therapeutics; viruses; Show all 16 Subjects
Abstract:
... The flowers of Trollius chinensis Bunge (Ranunculaceae) is a traditional Chinese medicine used to treat various inflammatory diseases, including upper respiratory infections, chronic tonsillitis, and pharyngitis. Recently, there has been growing research on the antiviral role of the flowers of T. chinensis Bunge. However, little is known about its anti-influenza virus effects and the underlying me ...
Itay Omer; Alina Rosenberg; Hanna Sefty; Rakefet Pando; Michal Mandelboim; Ella Mendelson; Lital Keinan-Boker; Aharona Glatman-Freedman; on behalf of the Israel Influenza Surveillance Network (IISN)
... Several countries have recently transitioned from the trivalent inactivated influenza vaccine (TIV) to the quadrivalent inactivated influenza vaccine (QIV) in order to outweigh influenza B vaccine-mismatch. However, few studies thus far evaluated its benefits versus the TIV in a systematic manner. Our objective was to compare the QIV VE with lineage-mismatched TIV VE. We estimated the 2015–2016, 2 ...
Influenza A virus; Influenza B virus; influenza, etc ; cross immunity; epitopes; hemagglutination; hemagglutinins; influenza vaccination; influenza vaccines; recombinant fusion proteins; virology; viruses; Show all 12 Subjects
Abstract:
... To improve cross-protection of influenza vaccination, we tested conjugation of conserved M2e epitopes to the surface of inactivated influenza virus (iPR8-M2e*). Treatment of virus with chemical cross-linker led to diminished hemagglutination activity and failure to induce hemagglutination inhibiting antibodies. Conjugated iPR8-M2e* vaccine was less protective against homologous and heterosubtypic ...
Amber Hsiao; John Hansen; Karen Valdez Nunley; Ned Lewis; Alex Selmani; Ajinkya Inamdar; Tamala Mallett-Moore; Ruvim Izikson; Deborah Rudin; Nicola P. Klein
influenza; influenza vaccination; influenza vaccines, etc ; observational studies; regression analysis; risk; California; Show all 7 Subjects
Abstract:
... Recombinant influenza vaccine (RIV) has been in use in US adults since 2013. This study evaluated the safety of quadrivalent recombinant influenza vaccine (RIV4, Flublok® Quadrivalent, Sanofi Pasteur) compared with standard-dose quadrivalent inactivated influenza vaccine (SD-IIV4) in self-identified Chinese adults at Kaiser Permanente Northern California (KPNC).This study evaluated adults aged 18– ...
influenza; influenza vaccination; influenza vaccines, etc ; heart failure; risk; risk reduction; stroke; Show all 7 Subjects
Abstract:
... Older adults are at high risk of major acute cardiovascular events (MACE) linked to influenza illness andpreventable by influenza vaccination. It is unknown whether high-dose vaccine might incrementally reduce the risk of MACE.We conducted a post-hoc analysis of data collected from a pragmatic cluster randomized study of 823 nursing homes (NH) randomized to standard-dose (SD) or high-dose (HD) inf ...
influenza; influenza vaccines, etc ; disease severity; risk; Show all 4 Subjects
Abstract:
... Benefit conferred by “enhanced” influenza vaccines is often measured by relative vaccine effectiveness, (rVE), which compares disease risk among groups of people who received alternative vaccines. Differences in attenuation of illness severity by vaccine types could manifest as differences in rVE. Using a simulated VE study and cohort of adults aged ≥ 65 years, we examined how rVE varied with assu ...
influenza; influenza vaccination; influenza vaccines, etc ; COVID-19 infection; databases; gender; monitoring; pruritus; Taiwan; Show all 9 Subjects
Abstract:
... During the COVID-19 pandemic, the need for influenza vaccine significantly increased in the initial weeks of the 2020–2021 influenza vaccination campaign season in Taiwan. To meet this demand, the Taiwanese government therefore purchased additional influenza vaccines via special import, including 350,000 doses of quadrivalent recombinant influenza vaccines (RIV4, Flublok Quadrivalent). Approved in ...
influenza; influenza vaccination; influenza vaccines, etc ; American Indians; COVID-19 infection; females; regression analysis; Show all 7 Subjects
Abstract:
... Recent data indicates increasing hesitancy towards both COVID-19 and influenza vaccination. We studied attitudes towards COVID-19 booster, influenza, and combination influenza-COVID-19 booster vaccines in a nationally representative sample of US adults between May and June 2021 (n = 12,887). We used pre-qualification quotes to ensure adequate sample sizes for minority populations. Overall vaccine ...
influenza; influenza vaccines, etc ; confidence interval; summer; Australia; Show all 5 Subjects
Abstract:
... An influenza outbreak occurred during summer (February 2019) in an aged-care facility in Sydney, Australia. Residents had not received the annual 2019 influenza vaccine while 76.7% had received 2018 influenza vaccines about 9 months prior. Overall, 2018 influenza vaccine effectiveness during this outbreak was high (93.6%). The effectiveness of the high-dose trivalent vaccine (HD-TIV) and adjuvante ...
influenza; influenza vaccination; influenza vaccines, etc ; COVID-19 infection; cohort studies; education; income; insurance; pandemic; Show all 9 Subjects
Abstract:
... Little is known about how the coronavirus disease 2019 (COVID-19) pandemic affected influenza vaccine utilization and disparities. We sought to estimate changes in the likelihood of receiving an influenza vaccine across different demographic subgroups during the COVID-19 pandemic. In this cohort study, we analyzed influenza vaccine uptake from 2019 to 2020 using Optum commercial insurance claims d ...
... Children are an important target group for influenza vaccination, but few studies have prospectively evaluated influenza vaccine efficacy (VE) in children under 3 years of age. This was a randomized Phase III trial to assess the efficacy, immunogenicity, and safety of an inactivated quadrivalent influenza vaccine (QIV) in young children (EudraCT: 2016–004904–74). Influenza-naïve children aged 6–35 ...
influenza; influenza vaccination, etc ; childhood; models; vaccines; United Kingdom; Show all 6 Subjects
Abstract:
... Annual vaccination of children against influenza is a key component of vaccination programs in many countries. However, past infection and vaccination may affect an individual’s susceptibility to infection. Little research has evaluated whether annual vaccination is the best strategy. Using the United Kingdom as our motivating example, we developed a framework to assess the impact of different chi ...
Influenza A virus; Influenza B virus; influenza, etc ; B-lymphocytes; animal models; immunoglobulin genes; immunoglobulin heavy chains; influenza vaccines; nose; vaccination; virion; viruses; Show all 12 Subjects
Abstract:
... The All-Japan Influenza Vaccine Study Group has been developing a more effective vaccine than the current split vaccines for seasonal influenza virus infection. In the present study, the efficacy of formalin- and/or β-propiolactone-inactivated whole virus particle vaccines for seasonal influenza was compared to that of the current ether-treated split vaccines in a nonhuman primate model. The monov ...
Helen Kuo; Janna R. Shapiro; Santosh Dhakal; Rosemary Morgan; Ashley L. Fink; Hsuan Liu; Jason W. Westerbeck; Kristyn E. Sylvia; Han-Sol Park; Rebecca L. Ursin; Patrick Shea; Kathryn Shaw-Saliba; Katherine Fenstermacher; Richard Rothman; Andrew Pekosz; Sabra L. Klein
influenza; influenza vaccination; influenza vaccines, etc ; blood serum; body mass index; females; health services; hospitals; males; seroconversion; Show all 10 Subjects
Abstract:
... Healthcare institutions with mandatory influenza vaccination policies have over 90% vaccination rates among healthcare workers (HCWs) resulting in a population that has received the influenza vaccine in many, consecutive years. This study explored the impact of sex and other host factors in pre- and post-vaccination neutralizing antibody (nAb) titers and seroconversion against the H1N1 and H3N2 in ...
Influenza B virus; influenza, etc ; human population; vaccine development; vaccines; Show all 5 Subjects
Abstract:
... In this review, we analyze the epidemiological and ecological features of influenza B, one of the most common and severe respiratory infections. The review presents various strategies for cross-protective influenza B vaccine development, including recombinant viruses, virus-like particles, and recombinant proteins. We provide an overview of viral proteins as cross-protective vaccine targets, along ...
Influenza A virus; human influenza, etc ; humans; plasmids; poultry; swine; Show all 6 Subjects
Abstract:
... The H1N1 subtype influenza viruses (H1N1) have been causing persistent epidemics in human, swine and poultry populations since 1918. This subtype has evolved into four relatively stable genetic lineages, including classical swine influenza virus lineage, seasonal human influenza virus lineage, avian influenza virus lineage and Eurasian avian-like swine influenza virus lineage. In this study, four ...
influenza; influenza vaccination; influenza vaccines, etc ; cognition; community health; health education; health promotion; health services; qualitative analysis; China; Show all 10 Subjects
Abstract:
... In the prevention and control of influenza, it is important for healthcare workers (HCWs) to be vaccinated and recommend influenza vaccines to their patients. However, there is limited evidence on the factors influencing uptake and promotion of influenza vaccination to patients among HCWs in China. We conducted in-depth interviews among HCWs in community health centers, including general practitio ...
Giorgia Sulis; Nicole E. Basta; Christina Wolfson; Susan A. Kirkland; Jacqueline McMillan; Lauren E. Griffith; Parminder Raina; on behalf of the Canadian Longitudinal Study on Aging (CLSA) Team
... Understanding how influenza vaccine uptake changed during the 2020/2021 influenza season compared to previous pre-pandemic seasons is a key priority, as is identifying the relationship between prior influenza vaccination and COVID-19 vaccine willingness.We analyzed data from a large, nationally representative cohort of Canadian residents aged 50 and older to assess influenza vaccination status thr ...
influenza; influenza vaccination; influenza vaccines, etc ; children; cohort studies; databases; death; hazard ratio; maternal exposure; mortality; Western Australia; Show all 11 Subjects
Abstract:
... Influenza vaccination is recommended to protect mothers and their infants from influenza. Few studies have evaluated the association between maternal influenza vaccination and child mortality. We aimed to evaluate the association between in utero exposure to seasonal inactivated influenza vaccine (IIV) and mortality among young children. This longitudinal, population-based cohort study included 19 ...
Influenza B virus; influenza; influenza vaccines, etc ; Escherichia coli; epitopes; hemagglutinins; humans; immunization; prediction; public health; solubility; vaccine development; Show all 12 Subjects
Abstract:
... Two lineages of influenza B viruses (IBV) co-circulating in human beings have been posing a significant public health burden worldwide. A substantial number of broadly neutralizing antibodies (bnAbs) have been identified targeting conserved epitopes on hemagglutinin (HA) stem domain, posing great interest for universal influenza vaccine development. Various strategies to design immunogens that sel ...