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1. The crude extract from the flowers of Trollius chinensis Bunge exerts anti-influenza virus effects through modulation of the TLR3 signaling pathway

Author:
Yuxi Liang; Xiaoli Liu; Jingyan Hu; Songli Huang; Xin Ma; Xiaoyan Liu; Rufeng Wang; Xiuhua Hu
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115743
ISSN:
0378-8741
Subject:
Influenza A virus,   etc   ; Oriental traditional medicine; Trollius chinensis; Western blotting; blood; cytoplasm; epithelium; fluorescent antibody technique; lungs; nasal cavity; pharmacology; pharyngitis; pneumonia; spleen; therapeutics; viruses;     Show all 16 Subjects
Abstract:
... The flowers of Trollius chinensis Bunge (Ranunculaceae) is a traditional Chinese medicine used to treat various inflammatory diseases, including upper respiratory infections, chronic tonsillitis, and pharyngitis. Recently, there has been growing research on the antiviral role of the flowers of T. chinensis Bunge. However, little is known about its anti-influenza virus effects and the underlying me ...
DOI:
10.1016/j.jep.2022.115743

2. Lineage-matched versus mismatched influenza B vaccine effectiveness following seasons of marginal influenza B circulation

Author:
Itay Omer; Alina Rosenberg; Hanna Sefty; Rakefet Pando; Michal Mandelboim; Ella Mendelson; Lital Keinan-Boker; Aharona Glatman-Freedman; on behalf of the Israel Influenza Surveillance Network (IISN)
Source:
Vaccine 2022 v.40 no.6 pp. 880-885
ISSN:
0264-410X
Subject:
influenza; influenza vaccines,   etc   ; Israel;     Show all 3 Subject
Abstract:
... Several countries have recently transitioned from the trivalent inactivated influenza vaccine (TIV) to the quadrivalent inactivated influenza vaccine (QIV) in order to outweigh influenza B vaccine-mismatch. However, few studies thus far evaluated its benefits versus the TIV in a systematic manner. Our objective was to compare the QIV VE with lineage-mismatched TIV VE. We estimated the 2015–2016, 2 ...
DOI:
10.1016/j.vaccine.2021.12.056

3. Impact of hemagglutination activity and M2e immunity on conferring protection against influenza viruses

Author:
Judy Oh; Jeeva Subbiah; Ki-Hye Kim; Bo Ryoung Park; Noopur Bhatnagar; Karla Ruiz Garcia; Rong Liu; Yu-Jin Jung; Chong-Hyun Shin; Baik-Lin Seong; Sang-Moo Kang
Source:
Virology 2022 v.574 pp. 37-46
ISSN:
0042-6822
Subject:
Influenza A virus; Influenza B virus; influenza,   etc   ; cross immunity; epitopes; hemagglutination; hemagglutinins; influenza vaccination; influenza vaccines; recombinant fusion proteins; virology; viruses;     Show all 12 Subjects
Abstract:
... To improve cross-protection of influenza vaccination, we tested conjugation of conserved M2e epitopes to the surface of inactivated influenza virus (iPR8-M2e*). Treatment of virus with chemical cross-linker led to diminished hemagglutination activity and failure to induce hemagglutination inhibiting antibodies. Conjugated iPR8-M2e* vaccine was less protective against homologous and heterosubtypic ...
DOI:
10.1016/j.virol.2022.07.010

4. Safety of recombinant quadrivalent influenza vaccine compared to inactivated influenza vaccine in Chinese adults: An observational study

Author:
Amber Hsiao; John Hansen; Karen Valdez Nunley; Ned Lewis; Alex Selmani; Ajinkya Inamdar; Tamala Mallett-Moore; Ruvim Izikson; Deborah Rudin; Nicola P. Klein
Source:
Vaccine 2022 v.40 no.5 pp. 774-779
ISSN:
0264-410X
Subject:
influenza; influenza vaccination; influenza vaccines,   etc   ; observational studies; regression analysis; risk; California;     Show all 7 Subjects
Abstract:
... Recombinant influenza vaccine (RIV) has been in use in US adults since 2013. This study evaluated the safety of quadrivalent recombinant influenza vaccine (RIV4, Flublok® Quadrivalent, Sanofi Pasteur) compared with standard-dose quadrivalent inactivated influenza vaccine (SD-IIV4) in self-identified Chinese adults at Kaiser Permanente Northern California (KPNC).This study evaluated adults aged 18– ...
DOI:
10.1016/j.vaccine.2021.12.035

5. High-Dose Influenza Vaccines for the Prevention of Hospitalization due to Cardiovascular Events in Older Adults in the Nursing Home: Post-hoc Analysis of a Cluster-Randomized Trial

Author:
Elie A. Saade; Yasin Abul; Kevin McConeghy; H Edward Davidson; Lisa Han; Nina Joyce; David H. Canaday; Leon Hsueh; Elliott Bosco; Stefan Gravensteinc
Source:
Vaccine 2022 pp. -
ISSN:
0264-410X
Subject:
influenza; influenza vaccination; influenza vaccines,   etc   ; heart failure; risk; risk reduction; stroke;     Show all 7 Subjects
Abstract:
... Older adults are at high risk of major acute cardiovascular events (MACE) linked to influenza illness andpreventable by influenza vaccination. It is unknown whether high-dose vaccine might incrementally reduce the risk of MACE.We conducted a post-hoc analysis of data collected from a pragmatic cluster randomized study of 823 nursing homes (NH) randomized to standard-dose (SD) or high-dose (HD) inf ...
DOI:
10.1016/j.vaccine.2022.09.085

6. Influence of disease attenuation on relative influenza vaccine effectiveness by vaccine type

Author:
Jill M. Ferdinands; Manish Patel
Source:
Vaccine 2022 v.40 no.19 pp. 2797-2801
ISSN:
0264-410X
Subject:
influenza; influenza vaccines,   etc   ; disease severity; risk;     Show all 4 Subjects
Abstract:
... Benefit conferred by “enhanced” influenza vaccines is often measured by relative vaccine effectiveness, (rVE), which compares disease risk among groups of people who received alternative vaccines. Differences in attenuation of illness severity by vaccine types could manifest as differences in rVE. Using a simulated VE study and cohort of adults aged ≥ 65 years, we examined how rVE varied with assu ...
DOI:
10.1016/j.vaccine.2022.03.012

7. National safety surveillance of quadrivalent recombinant influenza vaccine in Taiwan during NH 20/21

Author:
Szu-Ying Tsai; Ting-Yu Yeh; Nan-Chang Chiu; Ching-Tai Huang
Source:
Vaccine 2022 v.40 no.26 pp. 3701-3704
ISSN:
0264-410X
Subject:
influenza; influenza vaccination; influenza vaccines,   etc   ; COVID-19 infection; databases; gender; monitoring; pruritus; Taiwan;     Show all 9 Subjects
Abstract:
... During the COVID-19 pandemic, the need for influenza vaccine significantly increased in the initial weeks of the 2020–2021 influenza vaccination campaign season in Taiwan. To meet this demand, the Taiwanese government therefore purchased additional influenza vaccines via special import, including 350,000 doses of quadrivalent recombinant influenza vaccines (RIV4, Flublok Quadrivalent). Approved in ...
DOI:
10.1016/j.vaccine.2022.05.017

8. Underserved population acceptance of combination influenza-COVID-19 booster vaccines

Author:
Robert P. Lennon; Ray Block; Eric C. Schneider; Laurie Zephrin; Arnav Shah; The African American Research Collaborative 2021 COVID Group
Source:
Vaccine 2022 v.40 no.4 pp. 562-567
ISSN:
0264-410X
Subject:
influenza; influenza vaccination; influenza vaccines,   etc   ; American Indians; COVID-19 infection; females; regression analysis;     Show all 7 Subjects
Abstract:
... Recent data indicates increasing hesitancy towards both COVID-19 and influenza vaccination. We studied attitudes towards COVID-19 booster, influenza, and combination influenza-COVID-19 booster vaccines in a nationally representative sample of US adults between May and June 2021 (n = 12,887). We used pre-qualification quotes to ensure adequate sample sizes for minority populations. Overall vaccine ...
DOI:
10.1016/j.vaccine.2021.11.097

9. Effectiveness estimates for enhanced trivalent influenza vaccines in an aged care summer outbreak

Author:
Mohana Kunasekaran; Aye Moa; Elmira Hooshmand; Mallory Trent; Christopher J Poulos; Abrar A Chughtai; David J Heslop; C Raina MacIntyre
Source:
Vaccine 2022 pp. -
ISSN:
0264-410X
Subject:
influenza; influenza vaccines,   etc   ; confidence interval; summer; Australia;     Show all 5 Subjects
Abstract:
... An influenza outbreak occurred during summer (February 2019) in an aged-care facility in Sydney, Australia. Residents had not received the annual 2019 influenza vaccine while 76.7% had received 2018 influenza vaccines about 9 months prior. Overall, 2018 influenza vaccine effectiveness during this outbreak was high (93.6%). The effectiveness of the high-dose trivalent vaccine (HD-TIV) and adjuvante ...
DOI:
10.1016/j.vaccine.2022.06.018

10. Trends and disparities in the utilization of influenza vaccines among commercially insured US adults during the COVID-19 pandemic

Author:
Kun Li; Tianzhou Yu; Seth A. Seabury; Avi Dor
Source:
Vaccine 2022 v.40 no.19 pp. 2696-2704
ISSN:
0264-410X
Subject:
influenza; influenza vaccination; influenza vaccines,   etc   ; COVID-19 infection; cohort studies; education; income; insurance; pandemic;     Show all 9 Subjects
Abstract:
... Little is known about how the coronavirus disease 2019 (COVID-19) pandemic affected influenza vaccine utilization and disparities. We sought to estimate changes in the likelihood of receiving an influenza vaccine across different demographic subgroups during the COVID-19 pandemic. In this cohort study, we analyzed influenza vaccine uptake from 2019 to 2020 using Optum commercial insurance claims d ...
DOI:
10.1016/j.vaccine.2022.03.058

11. Efficacy and safety of a quadrivalent influenza vaccine in children aged 6–35 months: A global, multiseasonal, controlled, randomized Phase III study

Author:
Susanna Esposito; Jos Nauta; Giulia Lapini; Emanuele Montomoli; Serge van de Witte
Source:
Vaccine 2022 v.40 no.18 pp. 2626-2634
ISSN:
0264-410X
Subject:
influenza; influenza vaccination; influenza vaccines,   etc   ; antibodies; confidence interval; hemagglutination; hemagglutination inhibition test; immunogenicity; neutralization tests;     Show all 9 Subjects
Abstract:
... Children are an important target group for influenza vaccination, but few studies have prospectively evaluated influenza vaccine efficacy (VE) in children under 3 years of age. This was a randomized Phase III trial to assess the efficacy, immunogenicity, and safety of an inactivated quadrivalent influenza vaccine (QIV) in young children (EudraCT: 2016–004904–74). Influenza-naïve children aged 6–35 ...
DOI:
10.1016/j.vaccine.2022.02.088

12. Is annual vaccination best? A modelling study of influenza vaccination strategies in children

Author:
Kylie E.C. Ainslie; Steven Riley
Source:
Vaccine 2022 v.40 no.21 pp. 2940-2948
ISSN:
0264-410X
Subject:
influenza; influenza vaccination,   etc   ; childhood; models; vaccines; United Kingdom;     Show all 6 Subjects
Abstract:
... Annual vaccination of children against influenza is a key component of vaccination programs in many countries. However, past infection and vaccination may affect an individual’s susceptibility to infection. Little research has evaluated whether annual vaccination is the best strategy. Using the United Kingdom as our motivating example, we developed a framework to assess the impact of different chi ...
DOI:
10.1016/j.vaccine.2022.03.065

13. Inactivated whole influenza virus particle vaccines induce neutralizing antibodies with an increase in immunoglobulin gene subclones of B-lymphocytes in cynomolgus macaques

Author:
Masanori Shiohara; Saori Suzuki; Shintaro Shichinohe; Hirohito Ishigaki; Misako Nakayama; Naoki Nomura; Masashi Shingai; Toshiki Sekiya; Marumi Ohno; Sayaka Iida; Naoko Kawai; Mamiko Kawahara; Junya Yamagishi; Kimihito Ito; Ryotarou Mitsumata; Tomio Ikeda; Kenji Motokawa; Tomoyoshi Sobue; Hiroshi Kida; Kazumasa Ogasawara; Yasushi Itoh
Source:
Vaccine 2022 v.40 no.30 pp. 4026-4037
ISSN:
0264-410X
Subject:
Influenza A virus; Influenza B virus; influenza,   etc   ; B-lymphocytes; animal models; immunoglobulin genes; immunoglobulin heavy chains; influenza vaccines; nose; vaccination; virion; viruses;     Show all 12 Subjects
Abstract:
... The All-Japan Influenza Vaccine Study Group has been developing a more effective vaccine than the current split vaccines for seasonal influenza virus infection. In the present study, the efficacy of formalin- and/or β-propiolactone-inactivated whole virus particle vaccines for seasonal influenza was compared to that of the current ether-treated split vaccines in a nonhuman primate model. The monov ...
DOI:
10.1016/j.vaccine.2022.05.045

14. Sex-specific effects of age and body mass index on antibody responses to seasonal influenza vaccines in healthcare workers

Author:
Helen Kuo; Janna R. Shapiro; Santosh Dhakal; Rosemary Morgan; Ashley L. Fink; Hsuan Liu; Jason W. Westerbeck; Kristyn E. Sylvia; Han-Sol Park; Rebecca L. Ursin; Patrick Shea; Kathryn Shaw-Saliba; Katherine Fenstermacher; Richard Rothman; Andrew Pekosz; Sabra L. Klein
Source:
Vaccine 2022 v.40 no.11 pp. 1634-1642
ISSN:
0264-410X
Subject:
influenza; influenza vaccination; influenza vaccines,   etc   ; blood serum; body mass index; females; health services; hospitals; males; seroconversion;     Show all 10 Subjects
Abstract:
... Healthcare institutions with mandatory influenza vaccination policies have over 90% vaccination rates among healthcare workers (HCWs) resulting in a population that has received the influenza vaccine in many, consecutive years. This study explored the impact of sex and other host factors in pre- and post-vaccination neutralizing antibody (nAb) titers and seroconversion against the H1N1 and H3N2 in ...
DOI:
10.1016/j.vaccine.2021.02.047

15. Influenza B: Prospects for the Development of Cross-Protective Vaccines

Author:
Liudmila M. Tsybalova; Liudmila A. Stepanova; Edward S. Ramsay; Andrey V. Vasin
Source:
Viruses 2022 v.14 no.6 pp. -
ISSN:
1999-4915
Subject:
Influenza B virus; influenza,   etc   ; human population; vaccine development; vaccines;     Show all 5 Subjects
Abstract:
... In this review, we analyze the epidemiological and ecological features of influenza B, one of the most common and severe respiratory infections. The review presents various strategies for cross-protective influenza B vaccine development, including recombinant viruses, virus-like particles, and recombinant proteins. We provide an overview of viral proteins as cross-protective vaccine targets, along ...
DOI:
10.3390/v14061323

16. A SYBR Green-based real-time RT-PCR assay to differentiate the H1N1 influenza virus lineages

Author:
Yulin Cong; Yixue Sun; Xiaoyu Deng; Haiying Yu; Xiaohuan Lian; Yanlong Cong
Source:
Journal of virological methods 2022 v.300 pp. 114387
ISSN:
0166-0934
Subject:
Influenza A virus; human influenza,   etc   ; humans; plasmids; poultry; swine;     Show all 6 Subjects
Abstract:
... The H1N1 subtype influenza viruses (H1N1) have been causing persistent epidemics in human, swine and poultry populations since 1918. This subtype has evolved into four relatively stable genetic lineages, including classical swine influenza virus lineage, seasonal human influenza virus lineage, avian influenza virus lineage and Eurasian avian-like swine influenza virus lineage. In this study, four ...
DOI:
10.1016/j.jviromet.2021.114387

17. Barriers and facilitators to uptake and promotion of influenza vaccination among health care workers in the community in Beijing, China: A qualitative study

Author:
Mengke Yu; Xi Yao; Guangqi Liu; Jiang Wu; Min Lv; Yuanjie Pang; Zheng Xie; Yangmu Huang
Source:
Vaccine 2022 v.40 no.14 pp. 2202-2208
ISSN:
0264-410X
Subject:
influenza; influenza vaccination; influenza vaccines,   etc   ; cognition; community health; health education; health promotion; health services; qualitative analysis; China;     Show all 10 Subjects
Abstract:
... In the prevention and control of influenza, it is important for healthcare workers (HCWs) to be vaccinated and recommend influenza vaccines to their patients. However, there is limited evidence on the factors influencing uptake and promotion of influenza vaccination to patients among HCWs in China. We conducted in-depth interviews among HCWs in community health centers, including general practitio ...
DOI:
10.1016/j.vaccine.2022.02.060

18. Influenza vaccination uptake among Canadian adults before and during the COVID-19 pandemic: An analysis of the Canadian Longitudinal study on Aging (CLSA)

Author:
Giorgia Sulis; Nicole E. Basta; Christina Wolfson; Susan A. Kirkland; Jacqueline McMillan; Lauren E. Griffith; Parminder Raina; on behalf of the Canadian Longitudinal Study on Aging (CLSA) Team
Source:
Vaccine 2022 v.40 no.3 pp. 503-511
ISSN:
0264-410X
Subject:
influenza; influenza vaccination; influenza vaccines,   etc   ; COVID-19 infection; longitudinal studies; odds ratio; pandemic; regression analysis; sociodemographic characteristics;     Show all 9 Subjects
Abstract:
... Understanding how influenza vaccine uptake changed during the 2020/2021 influenza season compared to previous pre-pandemic seasons is a key priority, as is identifying the relationship between prior influenza vaccination and COVID-19 vaccine willingness.We analyzed data from a large, nationally representative cohort of Canadian residents aged 50 and older to assess influenza vaccination status thr ...
DOI:
10.1016/j.vaccine.2021.11.088

19. Maternal influenza vaccination and child mortality: Longitudinal, population-based linked cohort study

Author:
Damien Foo; Mohinder Sarna; Gavin Pereira; Hannah C. Moore; Annette K. Regan
Source:
Vaccine 2022 v.40 no.27 pp. 3732-3736
ISSN:
0264-410X
Subject:
influenza; influenza vaccination; influenza vaccines,   etc   ; children; cohort studies; databases; death; hazard ratio; maternal exposure; mortality; Western Australia;     Show all 11 Subjects
Abstract:
... Influenza vaccination is recommended to protect mothers and their infants from influenza. Few studies have evaluated the association between maternal influenza vaccination and child mortality. We aimed to evaluate the association between in utero exposure to seasonal inactivated influenza vaccine (IIV) and mortality among young children. This longitudinal, population-based cohort study included 19 ...
DOI:
10.1016/j.vaccine.2022.05.030

20. A Hemagglutinin Stem Vaccine Designed Rationally by AlphaFold2 Confers Broad Protection against Influenza B Infection

Author:
Dian Zeng; Jiabao Xin; Kunyu Yang; Shuxin Guo; Qian Wang; Ying Gao; Huiqing Chen; Jiaqi Ge; Zhen Lu; Limin Zhang; Junyu Chen; Yixin Chen; Ningshao Xia
Source:
Viruses 2022 v.14 no.6 pp. -
ISSN:
1999-4915
Subject:
Influenza B virus; influenza; influenza vaccines,   etc   ; Escherichia coli; epitopes; hemagglutinins; humans; immunization; prediction; public health; solubility; vaccine development;     Show all 12 Subjects
Abstract:
... Two lineages of influenza B viruses (IBV) co-circulating in human beings have been posing a significant public health burden worldwide. A substantial number of broadly neutralizing antibodies (bnAbs) have been identified targeting conserved epitopes on hemagglutinin (HA) stem domain, posing great interest for universal influenza vaccine development. Various strategies to design immunogens that sel ...
DOI:
10.3390/v14061305