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1. Immunogenicity and safety of a quadrivalent inactivated influenza vaccine in healthy subjects aged 3 to 17 years old: A phase III, open label, single-arm study

Author:
Chang, Chia-Yuan; Cho, Ching-Yi; Lai, Chou-Cheng; Lu, Chun-Yi; Chang, Luan-Yin; Hung, Miao-Chiu; Huang, Li-Min; Wu, Keh-Gong
Source:
Vaccine 2020 v.38 no.22 pp. 3839-3846
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; children; hemagglutination; humans; immunogenicity; influenza; seroconversion; vaccination; Taiwan;     Show all 9 Subjects
Abstract:
... Quadrivalent influenza vaccines are particularly valuable during seasons in which a mismatch occurs between the predicted influenza B lineage for the trivalent influenza vaccine and the circulating strain. This study evaluated the immunogenicity and safety of a quadrivalent inactivated influenza vaccine AdimFlu-S manufactured in Taiwan for the 2016–2017 influenza season in healthy children.A total ...
DOI:
10.1016/j.vaccine.2020.03.048

2. The risk of febrile seizures following influenza and 13-valent pneumococcal conjugate vaccines

Author:
Baker, Meghan A.; Jankosky, Christopher; Yih, W. Katherine; Gruber, Susan; Li, Lingling; Cocoros, Noelle M.; Lipowicz, Hana; Coronel-Moreno, Claudia; DeLuccia, Sandra; Lin, Nancy D.; McMahill-Walraven, Cheryl N.; Menschik, David; Selvan, Mano S.; Selvam, Nandini; Chen Tilney, Rong; Zichittella, Lauren; Lee, Grace M.; Kawai, Alison Tse
Source:
Vaccine 2020 v.38 no.9 pp. 2166-2171
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; Streptococcus pneumoniae; children; influenza; risk; seizures;     Show all 6 Subjects
Abstract:
... Evidence on the risk of febrile seizures after inactivated influenza vaccine (IIV) and 13-valent pneumococcal conjugate vaccine (PCV13) is mixed. In the FDA-sponsored Sentinel Initiative, we examined risk of febrile seizures after IIV and PCV13 in children 6–23 months of age during the 2013–14 and 2014–15 influenza seasons.Using claims data and a self-controlled risk interval design, we compared t ...
DOI:
10.1016/j.vaccine.2020.01.046

3. Does having a seasonal influenza program facilitate pandemic preparedness? An analysis of vaccine deployment during the 2009 pandemic

Author:
Porter, Rachael M.; Goldin, Shoshanna; Lafond, Kathryn E.; Hedman, Lisa; Ungkuldee, Mellissa; Kurzum, Jordan; Azziz-Baumgartner, Eduardo; Nannei, Claudia; Bresee, Joseph S.; Moen, Ann
Source:
Vaccine 2020 v.38 no.5 pp. 1152-1159
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; confidence interval; influenza; models; monitoring; pandemic; vaccination;     Show all 7 Subjects
Abstract:
... National seasonal influenza programs have been recommended as a foundation for pandemic preparedness. During the 2009 pandemic, WHO aimed to increase Member States’ equitable access to influenza vaccines through pandemic vaccine donation.This analysis explores whether the presence of a seasonal influenza program contributed to more rapid national submission of requirements to receive vaccine durin ...
DOI:
10.1016/j.vaccine.2019.11.025
PubMed:
31839465
PubMed Central:
PMC6992512

4. Swine influenza virus: Current status and challenge

Author:
Ma, Wenjun
Source:
Virus research 2020 v.288 pp. 198118
ISSN:
0168-1702
Subject:
influenza vaccines,   etc   ; Influenza A virus; disease control; genotype; humans; pandemic; pork industry; swine; swine influenza;     Show all 9 Subjects
Abstract:
... Since swine influenza virus was first isolated in 1930, it has become endemic in pigs worldwide. Although large amount of swine influenza vaccines has been used in swine industry, swine influenza still cannot be efficiently controlled and has been an important economic disease for swine industry. The high diversity and varied distribution of different subtypes and genotypes of swine influenza viru ...
DOI:
10.1016/j.virusres.2020.198118

5. Immunizations at Wisconsin Pharmacies: Results of a statewide vaccine registry analysis and pharmacist survey

Author:
Berce, Philip C.; Bernstein, Rebecca S.; MacKinnon, George E.; Sorum, Sarah; Martin, Erica; MacKinnon, Karen J.; Rein, Lisa E.; Schellhase, Kenneth G.
Source:
Vaccine 2020 v.38 no.28 pp. 4448-4456
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; Papillomaviridae; attitudes and opinions; health insurance; issues and policy; patients; physicians; surveys; vaccination; Wisconsin;     Show all 10 Subjects
Abstract:
... There is currently limited data in the United States on the proportion of immunization doses given at pharmacies outside the influenza vaccine. This study aims to obtain baseline information on the percentage of vaccine doses administered at pharmacies in Wisconsin and to understand the immunization barriers for Wisconsin pharmacists, to inform interventions to increase immunization access at phar ...
DOI:
10.1016/j.vaccine.2020.04.043

6. Antibody responses to influenza A(H1N1)pdm infection

Author:
Wraith, Steph; Nachbagauer, Raffael; Balmaseda, Angel; Stadlbauer, Daniel; Ojeda, Sergio; Rajabhathor, Arvind; Lopez, Roger; Guglia, Andrea F.; Sanchez, Nery; Amanat, Fatima; Gresh, Lionel; Kuan, Guillermina; Krammer, Florian; Gordon, Aubree
Source:
Vaccine 2020 v.38 no.27 pp. 4221-4225
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; antibodies; antibody formation; hemagglutinins; humoral immunity; influenza; polymerase chain reaction; sialidase;     Show all 8 Subjects
Abstract:
... We investigated humoral immune response to influenza A(H1N1)pdm infection and found 32 (22%) of the infected individuals identified by PCR failed to produce a ≥ 4-fold hemagglutinin inhibition assay (HAI) response; a subset of 18 (56%) produced an alternate antibody response (against full-length HA, HA stalk, or neuraminidase). These individuals had lower pre-existing HAI antibody titers and showe ...
DOI:
10.1016/j.vaccine.2020.04.069

7. Investigating the association of receipt of seasonal influenza vaccine with occurrence of anesthesia/paresthesia and severe headaches, Canada 2012/13–2016/17, the Canadian Vaccine Safety Network

Author:
Ahmed, May A.; Naus, Monika; Singer, Joel; Valiquette, Louis; Coleman, Brenda L.; De Serres, Gaston; Vanderkooi, Otto G.; Top, Karina A.; Isenor, Jennifer E.; Kellner, James D.; McCarthy, Anne E.; Bettinger, Julie A.
Source:
Vaccine 2020 v.38 no.19 pp. 3582-3590
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; anesthesia; clinical trials; headache; influenza vaccination; odds ratio; regression analysis; Canada;     Show all 8 Subjects
Abstract:
... Concern about adverse events following immunization is frequently cited by both those who receive or decline vaccines. Neurological adverse events are especially concerning.Our aim was to detect associations between seasonal influenza vaccination and the occurrence of severe anesthesia/paresthesia or severe headaches.Data were analyzed from the Canadian National Vaccine Safety network. Events occu ...
DOI:
10.1016/j.vaccine.2020.03.018

8. Impact of media reports regarding influenza vaccine on obstetricians’ vaccination practices

Author:
O'Leary, Sean T.; Cataldi, Jessica R.; Lindley, Megan C.; Hurley, Laura P.; Riley, Laura E.; Brtnikova, Michaela; Crane, Lori A.; Beaty, Brenda; Stokley, Shannon; Fisher, Allison; Kempe, Allison
Source:
Vaccine 2020 v.38 no.18 pp. 3474-3479
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; abortion (animals); attitudes and opinions; influenza; influenza vaccination; patients; pregnant women; risk; surveys;     Show all 9 Subjects
Abstract:
... In 2017, three media stories regarding influenza vaccine may have impacted obstetricians’ (OB) influenza vaccination practices: reports of reduced influenza vaccine effectiveness, a severe influenza season, and a possible increased risk of miscarriage among pregnant women receiving 2009 H1N1 vaccine in the 1st trimester who had received H1N1 vaccine the previous season (later disproven).Describe O ...
DOI:
10.1016/j.vaccine.2020.02.051

9. Fatal outcomes following immunization errors as reported to the EudraVigilance: A case series

Author:
Hoeve, Christina E.; Gadroen, Kartini; Kwa, Marcel S.G.; van Haren, Anja; Sturkenboom, Miriam C.J.M.; Straus, Sabine M.J.M.
Source:
Vaccine 2020 v.38 no.15 pp. 3086-3095
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; Streptococcus pneumoniae; adverse effects; education; immunization; live vaccines; measles; patients; quality control; rabies; screening;     Show all 11 Subjects
Abstract:
... Serious adverse reactions after immunization are rare but do occur. In very rare instances, cases with fatal outcome have been reported. These reports can have a huge impact and even more so when due to an immunization error. The aim of this study is to systematically review immunization errors with fatal outcomes in EudraVigilance.This was a case-series analysis of Individual Case Safety Reports ...
DOI:
10.1016/j.vaccine.2020.02.074

10. Influenza vaccine effectiveness against influenza-associated hospitalization in children: A systematic review and meta-analysis

Author:
Kalligeros, Markos; Shehadeh, Fadi; Mylona, Evangelia K.; Dapaah-Afriyie, Christine; van Aalst, Robertus; Chit, Ayman; Mylonakis, Eleftherios
Source:
Vaccine 2020 v.38 no.14 pp. 2893-2903
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; children; databases; elderly; influenza; influenza vaccination; meta-analysis; risk; systematic review;     Show all 9 Subjects
Abstract:
... Vaccination remains the most effective way to prevent influenza infection, albeit vaccine effectiveness (VE) varies by year. Compared to other age groups, children and elderly adults have the highest risk of developing influenza-related complications and requiring hospitalization. During the last years, “test negative design” (TND) studies have been implemented in order to estimate influenza VE. T ...
DOI:
10.1016/j.vaccine.2020.02.049

11. Association between health insurance coverage and uptake of seasonal influenza vaccine in Brazos County, Texas

Author:
Akpalu, Yao; Sullivan, Seth J.; Regan, Annette K.
Source:
Vaccine 2020 v.38 no.9 pp. 2132-2135
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; adults; health insurance; health services; influenza; influenza vaccination; medical records; regression analysis; risk; Texas;     Show all 10 Subjects
Abstract:
... Lack of health insurance may limit access to influenza vaccination, resulting in higher risk of infection.The Brazos County Health Department obtained medical records summarizing vaccination and health insurance status of all influenza cases occurring in December 2017 (n = 417). The odds of influenza vaccination were estimated for those with public or private health insurance as compared to uninsu ...
DOI:
10.1016/j.vaccine.2020.01.029

12. Comparison of alpha-spending plans for near real-time monitoring for Guillain-Barré Syndrome after influenza vaccination during the 2010/11 influenza season

Author:
Sandhu, Sukhminder K.; Hua, Wei; MaCurdy, Thomas E.; Franks, Riley L.; Avagyan, Armen; Chillarige, Yoganand; Wernecke, Michael; Kelman, Jeffrey; Ball, Robert
Source:
Vaccine 2020 v.38 no.9 pp. 2221-2228
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; Guillain-Barre Syndrome; influenza; influenza vaccination; monitoring; relative risk; United States;     Show all 7 Subjects
Abstract:
... Near real-time surveillance of the influenza vaccine, which is administered to a large proportion of the US population every year, is essential to ensure safety of the vaccine. For efficient near real-time surveillance, it is key to select appropriate parameters such as monitoring start date, number of interim tests and a scheme for spending a pre-defined total alpha across the entire influenza se ...
DOI:
10.1016/j.vaccine.2019.12.032

13. Effectiveness of the current and prior influenza vaccinations in Northern Spain, 2018–2019

Author:
Castilla, Jesús; Portillo, María Eugenia; Casado, Itziar; Pozo, Francisco; Navascués, Ana; Adelantado, Marta; Gómez Ibáñez, Carlos; Ezpeleta, Carmen; Martínez-Baz, Iván
Source:
Vaccine 2020 v.38 no.8 pp. 1925-1932
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; confidence interval; general practitioners; hospitals; influenza; influenza vaccination; patients; protective effect; California; Michigan; Spain;     Show all 11 Subjects
Abstract:
... The population targeted for influenza vaccination can be repeatedly vaccinated over successive seasons, and vaccines received in previous seasons may retain preventive effect. This study aims to estimate the effectiveness of inactivated influenza vaccines received in the current and prior seasons in the 2018–2019 season.Influenza-like illness patients attended by sentinel general practitioners or ...
DOI:
10.1016/j.vaccine.2020.01.028

14. Factors associated with perceptions of influenza vaccine safety and effectiveness among adults, United States, 2017–2018

Author:
Lutz, Chelsea S.; Fink, Rebecca V.; Cloud, Ann J.; Stevenson, John; Kim, David; Fiebelkorn, Amy Parker
Source:
Vaccine 2020 v.38 no.6 pp. 1393-1401
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; Internet; adults; influenza; morbidity; mortality; surveys; t-test; vaccination; United States;     Show all 10 Subjects
Abstract:
... Annual vaccination against seasonal influenza is widely recognized as the primary intervention method in preventing morbidity and mortality from influenza, but coverage among adults is suboptimal in the United States. Safety and effectiveness perceptions regarding vaccines are consistently cited as factors that influence adults’ decisions to accept or reject vaccination. Therefore, we conducted th ...
DOI:
10.1016/j.vaccine.2019.12.004

15. A study to evaluate the immunogenicity and shedding of live attenuated influenza vaccine strains in children 24–<48 months of age

Author:
Mallory, Raburn M.; Nyborg, Andrew; Kalyani, Rubana N.; Yuan, Yuan; Block, Stan L.; Dubovsky, Filip
Source:
Vaccine 2020 v.38 no.5 pp. 1001-1008
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; children; hemagglutination; immunogenicity; immunoglobulin A; influenza; live vaccines; males; neutralizing antibodies; nose; Bolivia; Slovenia;     Show all 12 Subjects
Abstract:
... Quadrivalent live attenuated influenza vaccine (LAIV4) showed reduced effectiveness against the A/H1N1 component in the 2013–2014 and 2015–2016 influenza seasons. The most likely cause of reduced LAIV effectiveness against A(H1N1)pdm09 strains was poor intranasal replication.To compare the immunogenicity and shedding of a new A/H1N1 strain (A/Slovenia), to a A/H1N1 strain known to have reduced eff ...
DOI:
10.1016/j.vaccine.2019.11.055

16. Using immersive virtual reality to improve the beliefs and intentions of influenza vaccine avoidant 18-to-49-year-olds: Considerations, effects, and lessons learned

Author:
Nowak, Glen J.; Evans, Nathaniel J.; Wojdynski, Bartosz W.; Ahn, Sun Joo (Grace); Len-Rios, Maria E.; Carera, Karen; Hale, Scott; McFalls, Deborah
Source:
Vaccine 2020 v.38 no.5 pp. 1225-1233
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; adults; computer simulation; education; experimental design; herd immunity; influenza; influenza vaccination; pamphlets; United States;     Show all 10 Subjects
Abstract:
... Only one-third of adults 18–49 years old in the United States receive a recommended annual influenza vaccination. This study examined whether supplementing vaccine information statements (VIS) with an immersive virtual reality (VR), short video or electronic pamphlet story designed to convey the community immunity benefits of influenza vaccination would improve influenza vaccine avoidant participa ...
DOI:
10.1016/j.vaccine.2019.11.009

17. Quantification of the total neuraminidase content of recent commercially-available influenza vaccines: Introducing a neuraminidase titration reagent

Author:
Gao, Zhizeng; Robinson, Kyle; Skowronski, Danuta M.; De Serres, Gaston; Withers, Stephen G.
Source:
Vaccine 2020 v.38 no.4 pp. 715-718
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; fluorometry; immune response; influenza; sialidase; surface proteins; titration; North America;     Show all 8 Subjects
Abstract:
... The protective immunological effects of the influenza neuraminidase (NA) surface protein are of renewed interest but NA content in vaccines remains unstandardized and methods to easily and reliably quantify NA content are unsatisfactory. We describe the use of a recently developed fluorometric titration reagent, TR1, to efficiently quantify the total enzymatically active NA content of six commerci ...
DOI:
10.1016/j.vaccine.2019.11.041

18. A phase 1, randomized, observer blind, antigen and adjuvant dosage finding clinical trial to evaluate the safety and immunogenicity of an adjuvanted, trivalent subunit influenza vaccine in adults ≥ 65 years of age

Author:
Otten, Gillis; Matassa, Vincent; Ciarlet, Max; Leav, Brett
Source:
Vaccine 2020 v.38 no.3 pp. 578-587
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; adjuvants; adults; antigens; clinical trials; confidence interval; hemagglutination; immunogenicity; seroconversion; vaccination;     Show all 10 Subjects
Abstract:
... To assess the safety and immunogenicity of the MF59®-adjuvanted trivalent influenza vaccine (aTIV; Fluad®) compared with modified aTIV formulations.A total of 196 subjects ≥ 65 years were randomized to receive7different formulations of vaccine containing a range of adjuvant and antigen dosesby single injection, or divided into two injections at a single time point. The primary study objective was ...
DOI:
10.1016/j.vaccine.2019.10.058

19. End of season influenza vaccine effectiveness in primary care in adults and children in the United Kingdom in 2018/19

Author:
Pebody, Richard G.; Whitaker, Heather; Ellis, Joanna; Andrews, Nick; Marques, Diogo F.P.; Cottrell, Simon; Reynolds, Arlene J.; Gunson, Rory; Thompson, Catherine; Galiano, Monica; Lackenby, Angie; Robertson, Chris; O'Doherty, Mark G.; Owens, Katie; Yonova, Ivelina; Shepherd, Samantha J.; Moore, Catherine; Johnston, Jillian; Donati, Matthew; McMenamin, Jim; Lusignan, Simon de; Zambon, Maria
Source:
Vaccine 2020 v.38 no.3 pp. 489-497
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; adults; childhood; children; control methods; influenza; influenza vaccination; live vaccines; United Kingdom;     Show all 9 Subjects
Abstract:
... 2018/19 was the first season of introduction of a newly licensed adjuvanted influenza vaccine (aTIV) for adults aged 65 years and over and the sixth season in the roll-out of a childhood influenza vaccination programme with a quadrivalent live attenuated influenza vaccine (LAIV). The season saw mainly A(H1N1)pdm09 and latterly A(H3N2) circulation.End-of-season adjusted vaccine effectiveness (aVE) ...
DOI:
10.1016/j.vaccine.2019.10.071

20. Effectiveness of influenza vaccine in children in preventing influenza associated hospitalisation, 2018/19, England

Author:
Pebody, R.G.; Zhao, H.; Whitaker, H.J.; Ellis, J.; Donati, M.; Zambon, M.; Andrews, N.
Source:
Vaccine 2020 v.38 no.2 pp. 158-164
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; children; general practitioners; influenza; live vaccines; monitoring; reverse transcriptase polymerase chain reaction; England;     Show all 8 Subjects
Abstract:
... 2013/14 saw the start of the introduction of a new live attenuated influenza vaccine (LAIV) programme for children in England. 2018/19 saw co-circulation of both A(H1N1)pdm09 and A(H3N2), when LAIV was offered to all healthy children 2–9 years of age. LAIV effectiveness against influenza hospitalisation is not well described. This paper presents the 2018/19 end-of-season adjusted vaccine effective ...
DOI:
10.1016/j.vaccine.2019.10.035