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1. Effectiveness of inactivated influenza vaccine in children by vaccine dose, 2013–18

Author:
Shinjoh, Masayoshi; Sugaya, Norio; Furuichi, Munehiro; Araki, Eriko; Maeda, Naonori; Isshiki, Kyohei; Ohnishi, Takuma; Nakamura, Shoko; Yamada, Go; Narabayashi, Atsushi; Nishida, Mitsuhiro; Taguchi, Nobuhiko; Nakata, Yuji; Yoshida, Makoto; Tsunematsu, Kenichiro; Shibata, Meiwa; Munenaga, Takeshi; Hirano, Yasuhiro; Ookawara, Ichiro; Sekiguchi, Shinichiro; Kobayashi, Yasuaki; Yamaguchi, Yoshio; Yoshida, Naoko; Mitamura, Keiko; Takahashi, Takao
Source:
Vaccine 2019 v.37 no.30 pp. 4047-4054
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; children; fever; hospitals; influenza; Japan;     Show all 6 Subjects
Abstract:
... We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) by vaccine dose in children aged 6 months to 12 years for whom two doses are recommended in Japan to ascertain the appropriate vaccine doses.VE was assessed according to a test-negative case-control design based on rapid influenza diagnostic test (RIDT) results. Children aged 6 months to 12 years with a fever ≥38 °C ...
DOI:
10.1016/j.vaccine.2019.05.090

2. “Breathing” Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design

Author:
Wu, Yan; Gao, George F.
Source:
Cell 2019 v.177 no.5 pp. 1086-1088
ISSN:
0092-8674
Subject:
influenza vaccines,   etc   ; epitopes; glycoproteins; hemagglutinins; influenza;     Show all 5 Subjects
Abstract:
... A universal vaccine against influenza remains a critical target, and efforts have recently focused on the stem of the hemagglutinin glycoprotein. In this issue of Cell and a related Cell Host & Microbe article, three studies identify broad protective epitopes in the hemagglutinin head domain that are exposed by trimer “breathing.” ...
DOI:
10.1016/j.cell.2019.04.034

3. Vaccine-preventable diseases, vaccines and Guillain-Barre’ syndrome

Author:
Principi, Nicola; Esposito, Susanna
Source:
Vaccine 2019 v.37 no.37 pp. 5544-5550
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; Papillomaviridae; influenza; measles; people; risk; risk reduction; vaccination;     Show all 8 Subjects
Abstract:
... Guillain–Barré syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy. Infections and vaccines have been hypothesized to play a role in triggering GBS development. These beliefs can play a role in reducing vaccination coverage. In this report, data concerning this hypothesis are discussed. It is shown that an association between vaccine administration and GBS has never been proven for ...
DOI:
10.1016/j.vaccine.2018.05.119

4. Impact of seasonal influenza vaccination in the presence of vaccine interference

Author:
Shim, Eunha; Smith, Kenneth J.; Nowalk, Mary Patricia; Raviotta, Jonathan M.; Brown, Shawn T.; DePasse, Jay; Zimmerman, Richard K.
Source:
Vaccine 2018 v.36 no.6 pp. 853-858
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; influenza; influenza vaccination; models;     Show all 4 Subjects
Abstract:
... Annual influenza vaccination is a key to preventing widespread influenza infections. Recent reports of influenza vaccine effectiveness (VE) indicate that vaccination in prior years may reduce VE in the current season, suggesting vaccine interference. The purpose of this study is to evaluate the potential effect of repeat influenza vaccinations in the presence of vaccine interference.Using literatu ...
DOI:
10.1016/j.vaccine.2017.12.067

5. Can routinely collected laboratory and health administrative data be used to assess influenza vaccine effectiveness? Assessing the validity of the Flu and Other Respiratory Viruses Research (FOREVER) Cohort

Author:
Kwong, Jeffrey C.; Buchan, Sarah A.; Chung, Hannah; Campitelli, Michael A.; Schwartz, Kevin L.; Crowcroft, Natasha S.; Jackson, Michael L.; Karnauchow, Timothy; Katz, Kevin; McGeer, Allison J.; McNally, J. Dayre; Richardson, David C.; Richardson, Susan E.; Rosella, Laura C.; Simor, Andrew; Smieja, Marek; Zahariadis, George; Campigotto, Aaron; Gubbay, Jonathan B.
Source:
Vaccine 2019 v.37 no.31 pp. 4392-4400
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; elderly; health services; influenza; laboratory experimentation; odds ratio; patients; vaccination; viruses;     Show all 9 Subjects
Abstract:
... Linking data on laboratory specimens collected during clinical practice with health administrative data permits highly powered vaccine effectiveness (VE) studies to be conducted at relatively low cost, but bias from using convenience samples is a concern. We evaluated the validity of using such data for estimating VE.We created the Flu and Other Respiratory Viruses Research (FOREVER) Cohort by lin ...
DOI:
10.1016/j.vaccine.2019.06.011

6. Influenza immunisation coverage from 2015 to 2017: A national study of adult patients from Australian general practice

Author:
De Oliveira Bernardo, Carla; González-Chica, David Alejandro; Chilver, Monique; Stocks, Nigel
Source:
Vaccine 2019 v.37 no.31 pp. 4268-4274
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; adults; comorbidity; indigenous peoples; influenza; national surveys; patients; vaccination;     Show all 8 Subjects
Abstract:
... To assess influenza immunisation rates and coverage in adult patients from Australian general practice and identify whether practice or patients’ characteristics are associated with vaccination uptake.Open cohort study.550 Australian general practices included in the MedicineInsight database.Patients aged 18+ years who had at least one consultation during influenza season between 2015 and 2017. Tw ...
DOI:
10.1016/j.vaccine.2019.06.057

7. Comparing influenza vaccine effectiveness between cell-derived and egg-derived vaccines, 2017–2018 influenza season

Author:
DeMarcus, Laurie; Shoubaki, Lisa; Federinko, Susan
Source:
Vaccine 2019 v.37 no.30 pp. 4015-4021
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; adults; case-control studies; children; confidence interval; health services; influenza; monitoring; odds ratio; pathogens;     Show all 10 Subjects
Abstract:
... The Department of Defense Global Respiratory Pathogen Surveillance Program conducted a study to compare the differences in vaccine effectiveness (VE) of the cell-derived and egg-derived vaccines. DoD healthcare beneficiaries, excluding service members, that presented with influenza-like illness for the period of 1 October 2017 through 28 April 2018 were included in a test-negative case-control stu ...
DOI:
10.1016/j.vaccine.2019.06.004

8. Measuring the impact of a mandatory province-wide vaccinate-or-mask policy on healthcare worker absenteeism in British Columbia, Canada

Author:
Murti, Michelle; Otterstatter, Michael; Orth, Alison; Balshaw, Robert; Halani, Khalif; Brown, Paul D; Hejazi, Samar; Thompson, Darby; Allison, Sandra; Bharmal, Aamir; Dawar, Meena; Hoyano, Dee; Lee, Victoria; Naus, Monika; Pollock, Sue; Bevanda, John; Coughlin, Sandy; Fitzgerald, John; Keen, Dave; Maracle, Melanie; Sprague, Stacy; Henry, Bonnie
Source:
Vaccine 2019 v.37 no.30 pp. 4008-4014
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; health care workers; influenza; issues and policy; models; odds ratio; patients; British Columbia;     Show all 8 Subjects
Abstract:
... Vaccinate-or-mask (VOM) policies aim to improve influenza vaccine coverage among healthcare workers (HCW) and reduce influenza-related illness among patients and staff. In 2012, British Columbia (BC) implemented a province-wide VOM influenza prevention policy. This study describes an evaluation of policy impacts on HCW absenteeism rates from before to after policy implementation.Using payroll data ...
DOI:
10.1016/j.vaccine.2019.06.007

9. Comparison of a frailty short interview to a validated frailty index in adults hospitalized for acute respiratory illness

Author:
Petrie, Joshua G.; Martin, Emily T.; Zhu, Yuwei; Wyatt, Dayna G.; Kaniclides, Anne; Ferdinands, Jill M.; Monto, Arnold S.; Trabue, Christopher; Talbot, H. Keipp
Source:
Vaccine 2019 v.37 no.29 pp. 3849-3855
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; elderly; hospitals; influenza; influenza vaccination; medical records; men; patients; races; regression analysis; women;     Show all 11 Subjects
Abstract:
... Frailty is an important physiologic factor in studies of influenza and influenza vaccines carried out in older adults and hospitalized populations. Unfortunately, comprehensive assessments of frailty requiring physical assessments and extensive medical record review are not often feasible in time- and resource-limited settings common to studies of influenza and influenza vaccines.We developed a 5- ...
DOI:
10.1016/j.vaccine.2019.05.051

10. Evaluating the effectiveness of the influenza vaccine during respiratory outbreaks in Singapore’s long term care facilities, 2017

Author:
Ng, Yixiang; Nandar, Khine; Chua, Lily Ai Vee; Mak, Tze Minn; Foo, Kelly; Muhammad, Imran Roshan; Low, Constance Khia Ki; Ma, Stefan; Ooi, Steven Peng-Lim; Lin, Raymond Tzer Pin; James, Lyn; Lee, Vernon Jian Ming
Source:
Vaccine 2019 v.37 no.29 pp. 3925-3931
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; gender; influenza; long term care; regression analysis; risk; vaccination; Singapore;     Show all 8 Subjects
Abstract:
... Influenza outbreaks occur periodically in Long Term Care Facilities (LTCFs) and vaccination is critical in preventing influenza infections. We evaluated the influenza vaccine effectiveness (VE) during respiratory outbreaks in LTCFs reported to the Ministry of Health, Singapore in 2017.A test-negative design was used to estimate the ratio of the odds of testing positive for influenza among vaccinat ...
DOI:
10.1016/j.vaccine.2019.03.054

11. Surveillance for Guillain-Barré syndrome after influenza vaccination among U.S. Medicare beneficiaries during the 2017–2018 season

Author:
Perez-Vilar, Silvia; Wernecke, Michael; Arya, Deepa; Lo, An-Chi; Lufkin, Bradley; Hu, Mao; Chu, Steve; MaCurdy, Thomas E.; Kelman, Jeffrey; Forshee, Richard A.
Source:
Vaccine 2019 v.37 no.29 pp. 3856-3865
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; Food and Drug Administration; influenza vaccination; monitoring; morbidity; mortality; risk; United States;     Show all 8 Subjects
Abstract:
... The U.S. Food and Drug Administration and the Centers for Medicare & Medicaid Services have been actively monitoring the risk of Guillain-Barré syndrome (GBS) following influenza vaccination among Fee-for-Service (FFS) Medicare beneficiaries every season since 2008. We present our evaluation of the GBS risk following influenza vaccinations during the 2017–2018 season.We implemented a multilayered ...
DOI:
10.1016/j.vaccine.2019.05.041

12. Selective Capture and Determination of Receptor-Binding Hemagglutinin in Influenza Vaccine Preparations Using a Coupled Receptor-Binding/RP-HPLC Assay

Author:
Lorbetskie, Barry; Cunningham, Anna-Maria; Lemieux, Michèle; Durno, Laura; Farnsworth, Aaron; Wang, Junzhi; Li, Changgui; Li, Xuguang; Gilbert, Michel; Sauvé, Simon; Girard, Michel
Source:
Analytical chemistry 2019 v.91 no.14 pp. 8908-8917
ISSN:
1520-6882
Subject:
influenza vaccines,   etc   ; hemagglutinins; immunization; neutralizing antibodies; reversed-phase high performance liquid chromatography; sialic acid;     Show all 6 Subjects
Abstract:
... Influenza vaccine potency is determined by the quantification of immunologically active hemagglutinin capable of eliciting neutralizing antibodies upon immunization. Currently, the single radial immunodiffusion (SRID) method is the standard in vitro potency assay used for lot release of seasonal inactivated influenza vaccines. Despite the proven usage of SRID, significant limitations such as the t ...
DOI:
10.1021/acs.analchem.9b00617

13. Effectiveness of a multimodal intervention to increase vaccination in obstetrics/gynecology settings

Author:
O'Leary, Sean T.; Pyrzanowski, Jennifer; Brewer, Sarah E.; Sevick, Carter; Miriam Dickinson, L.; Dempsey, Amanda F.
Source:
Vaccine 2019 v.37 no.26 pp. 3409-3418
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; Papillomaviridae; control methods; educational materials; influenza; patient education; patients; pregnant women; purchasing; vaccination; Colorado;     Show all 11 Subjects
Abstract:
... To test the effectiveness of a multimodal intervention in obstetrics/gynecology (ob-gyn) clinics to increase uptake of influenza and tetanus-diphtheria-acellular pertussis (Tdap) vaccines in pregnant women and these vaccines plus human papillomavirus (HPV) vaccine in non-pregnant women.A cluster randomized controlled trial among 9 private ob-gyn practices in Colorado from 9/2011 to 5/2014. The int ...
DOI:
10.1016/j.vaccine.2019.05.034

14. New vaccine introductions in Africa before and during the decade of vaccines – Are we making progress?

Author:
Sambala, Evanson Z.; Wiyeh, Alison B.; Ngcobo, Ntombenhle; Machingaidze, Shingai; Wiysonge, Charles S.
Source:
Vaccine 2019 v.37 no.25 pp. 3290-3295
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; Haemophilus influenzae; Rotavirus; childhood; funding; hepatitis B; immunization; Africa;     Show all 8 Subjects
Abstract:
... Vaccines are excellent investments with far-reaching rewards beyond individual and population health, but their introduction into national programs has been historically slow in Africa. We provide an overview of the introduction of new and underutilized vaccines in countries of the WHO African Region by 2017, using data from the WHO-UNICEF Joint Reporting Form. By 2017, all 47 countries had introd ...
DOI:
10.1016/j.vaccine.2019.05.002

15. Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism

Author:
Watanabe, Akiko; McCarthy, Kevin R.; Kuraoka, Masayuki; Schmidt, Aaron G.; Adachi, Yu; Onodera, Taishi; Tonouchi, Keisuke; Caradonna, Timothy M.; Bajic, Goran; Song, Shengli; McGee, Charles E.; Sempowski, Gregory D.; Feng, Feng; Urick, Patricia; Kepler, Thomas B.; Takahashi, Yoshimasa; Harrison, Stephen C.; Kelsoe, Garnett
Source:
Cell 2019 v.177 no.5 pp. 1124-1135.e16
ISSN:
0092-8674
Subject:
influenza vaccines,   etc   ; B-lymphocytes; Orthomyxoviridae; antibodies; epitopes; hemagglutinins; humans; humoral immunity; immunoglobulin G; influenza; mice; pathogens;     Show all 12 Subjects
Abstract:
... Vaccines to generate durable humoral immunity against antigenically evolving pathogens such as the influenza virus must elicit antibodies that recognize conserved epitopes. Analysis of single memory B cells from immunized human donors has led us to characterize a previously unrecognized epitope of influenza hemagglutinin (HA) that is immunogenic in humans and conserved among influenza subtypes. St ...
DOI:
10.1016/j.cell.2019.03.048

16. The effect of silk peptide on immune system, A randomized, double-blind, placebo-controlled clinical trial

Author:
Hwang, Jin-Taek; Cho, Jung Min; Jeong, In Hye; Lee, Jeong-yong; Ha, Ki-Chan; Baek, Hyang-Im; Yang, Hye Jeong; Kim, Min Jung; Lee, Jong Ho
Source:
Journal of functional foods 2019 v.55 pp. 275-284
ISSN:
1756-4646
Subject:
influenza vaccines,   etc   ; clinical trials; immunostimulants; interferon-gamma; interleukin-12; interleukin-2; natural killer cells; placebos; silk;     Show all 9 Subjects
Abstract:
... In this study, we evaluated the immunostimulatory effect of silk peptide in subjects with peripheral blood leukocyte levels of 4–8 × 103/μl by a randomized, double-blind, placebo-controlled clinical trial. The subjects were randomly assigned to one of two groups, the placebo control or silk peptide intervention group, for 8 weeks. As a result, evaluation of efficacy in 97 subjects showed no signif ...
DOI:
10.1016/j.jff.2019.02.032

17. Remarkable Structural Diversity of N-Glycan Sulfation on Influenza Vaccines

Author:
She, Yi-Min; Li, Xuguang; Cyr, Terry D.
Source:
Analytical chemistry 2019 v.91 no.8 pp. 5083-5090
ISSN:
1520-6882
Subject:
influenza vaccines,   etc   ; databases; glycopeptides; glycoproteins; hemagglutinins; influenza; liquid chromatography; mass spectrometry; sequons; sialidase; sulfates; sulfotransferases; therapeutics;     Show all 13 Subjects
Abstract:
... Sulfated N-glycans are biologically important structures derived from enzymatically post-glycosylational modifications of glycoproteins in many therapeutic biologics. The high-throughput analysis of sulfated N-glycomes remains a daunting technical challenge, because of negatively charged heterogeneous composition, large molecular structures, lability of sulfate attachments, and a lack of highly se ...
DOI:
10.1021/acs.analchem.8b05372

18. Measuring vaccine hesitancy, confidence, trust and flu vaccine uptake: Results of a national survey of White and African American adults

Author:
Quinn, Sandra Crouse; Jamison, Amelia M.; An, Ji; Hancock, Gregory R.; Freimuth, Vicki S.
Source:
Vaccine 2019 v.37 no.9 pp. 1168-1173
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; African Americans; White Americans; adults; children; models; national surveys; United States;     Show all 8 Subjects
Abstract:
... Vaccine hesitancy (VH) has emerged as a factor in vaccine delay and refusal yet the measurement of the constructs within vaccine hesitancy remains a challenge. Outstanding questions include; should VH be measured as an attitude or a behavior? What is the role of key constructs including confidence, complacency, and convenience? What is the role of trust? Should measures be general or vaccine speci ...
DOI:
10.1016/j.vaccine.2019.01.033

19. Bias of influenza vaccine effectiveness estimates from test-negative studies conducted during an influenza pandemic

Author:
Ainslie, Kylie E.C.; Haber, Michael; Orenstein, Walter A.
Source:
Vaccine 2019
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; experimental design; health status; influenza; models; monitoring; pandemic; probability; vaccination;     Show all 9 Subjects
Abstract:
... Test-negative (TN) studies have become the most widely used study design for the estimation of influenza vaccine effectiveness (VE) and are easily incorporated into existing influenza surveillance networks. We seek to determine the bias of TN-based VE estimates during a pandemic using a dynamic probability model. The model is used to evaluate and compare the bias of VE estimates under various sour ...
DOI:
10.1016/j.vaccine.2019.02.036

20. Appropriateness and preferential use of different seasonal influenza vaccines: A pilot study on the opinion of vaccinating physicians in Italy

Author:
Boccalini, S.; Tacconi, F. Mandò; Lai, Piero Luigi; Bechini, A.; Bonanni, P.; Panatto, D.
Source:
Vaccine 2019 v.37 no.7 pp. 915-918
ISSN:
0264-410X
Subject:
influenza vaccines,   etc   ; attitudes and opinions; elderly; guidelines; health policy; markets; physicians; surveys; Italy; United Kingdom;     Show all 10 Subjects
Abstract:
... In Italy, several types of influenza vaccine are on the market. Available evidence suggests that no single vaccine type is universally appropriate; rather, different types may be more appropriate for different population strata. However, while the concept of appropriateness/preferential use of single vaccines is usually adopted at the central level, little is known about the attitudes of physician ...
DOI:
10.1016/j.vaccine.2018.12.057