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You searched for: Subject "innate immunity" Remove constraint Subject: "innate immunity"
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1. miR-92b-5p negatively regulates IKK through targeting its ORF region in the innate immune responses of amphioxus (Branchiostoma belcheri)

Author:
Yunpeng Cao; Ranting Li; Yongxin Du; Na Jin; Tao Fang; Fei Ma; Ping Jin
Source:
Developmental and comparative immunology 2023 v.138 pp. 104556
ISSN:
0145-305X
Subject:
innate immunity,   etc   ; Branchiostoma belcheri; RNA; phylogeny; protein content; vertebrates;     Show all 6 Subjects
Abstract:
... Cephalochordate (Amphioxus), situated at a key phylogenetic position in the phylum Chordata, serves as a model organism for studying the origin and evolution of the vertebrate innate immune. In this study, five members of precursor miR-92 family (miR-92a-1, miR-92a-2, miR-92b, miR-92c and miR-92d) are identified in Branchiostoma belcheri, and their evolutionary conservation and potential molecular ...
DOI:
10.1016/j.dci.2022.104556

2. Mushroom β-glucan and polyphenol formulations as natural immunity boosters and balancers: nature of the application

Author:
Maja Kozarski; Anita Klaus; Leo van Griensven; Dragica Jakovljevic; Nina Todorovic; Wan Abd Al Qadr Imad Wan-Mohtar; Jovana Vunduk
Source:
Food science and human wellness 2023 v.12 no.2 pp. 378-396
ISSN:
2213-4530
Subject:
innate immunity,   etc   ; bioavailability; biomedical research; cosmetics; dietary supplements; food science; health services; human nutrition; humans; industry; markets; mushrooms; polyphenols; secondary metabolites;     Show all 14 Subjects
Abstract:
... Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet. These valuable organisms are more than food, they fit in perfectly as a novel market group known as nutra-mycoceuticals. Immune-balancing mushroom dietary fibers and secondary metabolites such as polyphenols are the main focus of the healthcare industry. Wellness and cosmetic companies are increasingly using ...
DOI:
10.1016/j.fshw.2022.07.040

3. Prediction of intestinal stem cell regulatory genes from Drosophila gut damage model created using multiple inducers: Differential gene expression-based protein-protein interaction network analysis

Author:
Seung Hun Lee; Dooseon Hwang; Tae-Won Goo; Eun-Young Yun
Source:
Developmental and comparative immunology 2023 v.138 pp. 104539
ISSN:
0145-305X
Subject:
innate immunity,   etc   ; Drosophila melanogaster; gene expression regulation; genes; homeostasis; intestines; models; oral administration; prediction; protein-protein interactions; sequence analysis; stem cells;     Show all 12 Subjects
Abstract:
... Intestinal tissue functions in innate immunity to prevent the entry of harmful substances, and to maintain homeostasis through the constant proliferation of intestinal stem cells (ISC). To understand the mechanisms which regulate ISC in response to gut damage, we identified 81 differentially expressed genes (DEGs) through RNA-seq analysis after oral administration of three intestinal-damaging subs ...
DOI:
10.1016/j.dci.2022.104539

4. PRMT6 inhibits K63-linked ubiquitination and promotes the degradation of IRF3 in the antiviral innate immunity of black carp Mylopharyngodon piceus

Author:
Can Yang; Shisi Yang; Yujia Miao; Juanjuan Shu; Yuqing Peng; Jun Li; Hui Wu; Jun Zou; Hao Feng
Source:
Aquaculture 2023 v.562 pp. 738872
ISSN:
0044-8486
Subject:
innate immunity,   etc   ; Carp sprivivirus; Ctenopharyngodon idella; Mylopharyngodon piceus; Reoviridae; antiviral properties; aquaculture; chloroquine; fish; interferons; lysosomes; mammals; precipitin tests; protein content; type I protein arginine methyltransferase; ubiquitination;     Show all 16 Subjects
Abstract:
... Protein arginine methyltransferases (PRMT6) has been shown to negatively regulate interferon (IFN) production in mammals, however, the role of teleost PRMT6 in IFN signaling remains largely unknown. In our previous study, black carp (Mylopharyngodon piceus) PRMT6 (bcPRMT6) has been identified to inhibit bcTBK1/bcIRF3 cascade. In this study, bcIRF3-induced transcription of bcIFNa, bcIFNb, bcp50 and ...
DOI:
10.1016/j.aquaculture.2022.738872

5. Sex and reproductive development impact skin mucosal epithelium immunity, antimicrobial capacity, and up-regulation of immune-related gene of goldfish (Carassius auratus)

Author:
Zahra Roosta; Bahram Falahatkar; Mirmasoud Sajjadi; Hamed Paknejad; Arash Akbarzadeh; Patrick Kestemont
Source:
Developmental and comparative immunology 2023 v.138 pp. 104494
ISSN:
0145-305X
Subject:
innate immunity,   etc   ; Carassius auratus; Enterococcus faecium; Micrococcus luteus; Staphylococcus aureus; alkaline phosphatase; antimicrobial properties; calcium; complement; epithelium; females; gene expression; genes; goldfish; liver; lysozyme; males; models; mucosal immunity; peroxidase; spermatogenesis; spermiation; vitellogenesis;     Show all 23 Subjects
Abstract:
... This study evaluated the epidermis mucosal capacity of goldfish (Carassius auratus) during different stages of reproductive development in both females and males. In this regard, the activity of mucolytic immune enzymes, i.e., lysozyme, complement and peroxidase, as well as the activity of alkaline phosphatase (ALP) were evaluated. There were five stages for females i.e., immature (f1), cortical a ...
DOI:
10.1016/j.dci.2022.104494

6. Pomegranate (Punica granatum) peel extract supplementation in diet influences growth performance, haemato-immunological responses and cytokine expression in pathogen- aggravated Labeo rohita fingerlings

Author:
Sanjay Kumar Gupta; Akruti Gupta; Biplab Sarkar; Rajan Gupta; Madan Kumar; Aditi Kumari; Md. Javed Foysal
Source:
Aquaculture 2023 v.562 pp. 738823
ISSN:
0044-8486
Subject:
innate immunity,   etc   ; Aeromonas hydrophila; Labeo rohita; Punica granatum; aquaculture; blood proteins; dietary supplements; disease resistance; fish; gene expression; globulins; growth performance; interleukin-10; kidneys; liver; lysozyme; pomegranates; respiratory burst; specific growth rate;     Show all 19 Subjects
Abstract:
... Pomegranate peel extract (PPE) has been widely identified as a rich source of therapeutically active phyto-compounds, known for their beneficial effects in aquaculturable species. In this context, a 60-day feeding trial was carried out to evaluate the effect of supplementation of pomegranate peel extract (PPE) on growth performance, haemato-immunological responses and cytokine gene expression in L ...
DOI:
10.1016/j.aquaculture.2022.738823

7. Effects of synthetic astaxanthin and Haematococcus pluvialis on growth, antioxidant capacity, immune response, and hepato-morphology of Oncorhynchus mykiss under cage culture with flowing freshwater

Author:
Wei Zhao; Han-Lin Wei; Meng-Die Chen; Rong Yao; Zi-Qiao Wang; Jin Niu
Source:
Aquaculture 2023 v.562 pp. 738860
ISSN:
0044-8486
Subject:
innate immunity,   etc   ; Haematococcus pluvialis; Oncorhynchus mykiss; anti-inflammatory activity; antioxidant activity; astaxanthin; cage culture; complement; diet; fish; freshwater; growth performance; immune response; interleukin-8; lipids; liver; lysozyme; muscles; necrosis; neoplasms; pigmentation; superoxide dismutase;     Show all 22 Subjects
Abstract:
... A feeding experiment was carried out to compare the effects of dietary synthetic astaxanthin and Haematococcus pluvialis on growth, antioxidant capacity, immune response and hepato-morphology of Oncorhynchus mykiss under cage culture with flowing freshwater. Three isonitrogenous and isolipidic diets were formulated with or without synthetic astaxanthin and H. pluvialis and were administered to O. ...
DOI:
10.1016/j.aquaculture.2022.738860

8. Natural Immunity against HIV-1: Progression of Understanding after Association Studies

Author:
Ma Luo
Source:
Viruses 2022 v.14 no.6 pp. -
ISSN:
1999-4915
Subject:
innate immunity,   etc   ; females; immunogenetics;     Show all 3 Subjects
Abstract:
... Natural immunity against HIV has been observed in many individuals in the world. Among them, a group of female sex workers enrolled in the Pumwani sex worker cohort remained HIV uninfected for more than 30 years despite high-risk sex work. Many studies have been carried out to understand this natural immunity to HIV in the hope to develop effective vaccines and preventions. This review focuses on ...
DOI:
10.3390/v14061243

9. Immunity boosting roles of biofunctional compounds available in aquafoods: A review

Author:
Sharmin Suraiya; Mirja Kaizer Ahmmed; Monjurul Haq
Source:
Heliyon 2022 v.8 no.5 pp. e09547
ISSN:
2405-8440
Subject:
innate immunity,   etc   ; food intake; humans; immunomodulation;     Show all 4 Subjects
Abstract:
... Aquafoods are diverse and rich in containing various health functional compounds which boost natural immunity. In this manuscript, the contents of biofunctional compounds such as vitamins, minerals, protein and amino acids, ω-3 polyunsaturated fatty acids, and pigments, etc. in various aquafoods like fishes, molluscs, crustaceans, seaweeds etc. are reported. The functional roles of those compounds ...
DOI:
10.1016/j.heliyon.2022.e09547

10. Split-luciferase complementary assay of NLRP3 PYD-PYD interaction indicates inflammasome formation during inflammation

Author:
Mohsen Isazadeh; Mojdeh Amandadi; Farnaz Haghdoust; Shima Lotfollazadeh; Mar Orzáez; Saman Hosseinkhani
Source:
Analytical biochemistry 2022 v.638 pp. 114510
ISSN:
0003-2697
Subject:
innate immunity,   etc   ; biosensors; inflammasomes; inflammation; luciferase;     Show all 5 Subjects
Abstract:
... The NLRP3 inflammasome is a key macromolecular complex of the innate immune system that activates the inflammatory signalling cascade in response to a wide range of stimuli. Structural studies have shown that the intracellular cytosolic receptor NLRP3 oligomerizes upon stimulation and serves as a scaffold to form the ASC filaments necessary for procaspase-1 activation. Despite the abundant structu ...
DOI:
10.1016/j.ab.2021.114510

11. The interplay of plant hormonal pathways and geminiviral proteins: partners in disease development

Author:
Kanika Gupta; Rashmi Rishishwar; Indranil Dasgupta
Source:
Virus genes 2022 v.58 no.1 pp. 1-14
ISSN:
0920-8569
Subject:
innate immunity,   etc   ; Geminiviridae; plant hormones; viruses;     Show all 4 Subjects
Abstract:
... Viruses belonging to the family Geminiviridae infect plants and are responsible for a number of diseases of crops in the tropical and sub-tropical regions of the World. The innate immune response of the plant assists in its defense against such viral pathogens by the recognition of pathogen/microbe-associated molecular patterns through pattern-recognition receptors. Phytohormone signalling pathway ...
DOI:
10.1007/s11262-021-01881-6

12. Roles of pattern recognition receptors in response to fungal keratitis

Author:
Xiaolong Fang; Huifang Lian; Shihao Bi; Sijin Liu; Xiaoyong Yuan; Chunyang Liao
Source:
Life sciences 2022 v.307 pp. 120881
ISSN:
0024-3205
Subject:
innate immunity,   etc   ; blindness; cornea; fungi; keratitis;     Show all 5 Subjects
Abstract:
... Fungal keratitis is one of the leading causes of blindness worldwide, which has become an increasingly serious threat to public ocular health, but no effective treatment strategies are available now. Pattern recognition receptors (PRRs) of the innate immune system are the first line of host defense against fungal infections. They could recognize pathogen-associated molecular patterns (PAMPs) or da ...
DOI:
10.1016/j.lfs.2022.120881

13. Zw10 negatively regulates the MyD88-mediated NF-κB signaling through autophagy in teleost fish

Author:
Baolan Cao; Ya Chen; Junxia Cui; Yuena Sun; Tianjun Xu
Source:
Developmental and comparative immunology 2022 v.132 pp. 104401
ISSN:
0145-305X
Subject:
innate immunity,   etc   ; autophagy; cell proliferation; fish;     Show all 4 Subjects
Abstract:
... MyD88 is a typical street protein of the TLRs signaling pathway and is a central player in innate immune signaling, which can regulate the NF-κB signaling pathway and promote downstream inflammatory factors. However, studies on the molecular mechanisms of the MyD88-mediated NF-κB signaling pathway in teleosts have been poorly reported. In this study, we report that Zw10 targets MyD88 to inhibit NF ...
DOI:
10.1016/j.dci.2022.104401

14. miR-2013 negatively regulates phylogenetically conserved PIP5K involved in TLR4 mediated immune responses of amphioxus (Branchiostoma belcheri Tsingtaunese)

Author:
Yunpeng Cao; Tao Fang; Yongxin Du; Ranting Li; Mingli Fan; Fei Ma; Ping Jin
Source:
Developmental and comparative immunology 2022 v.133 pp. 104430
ISSN:
0145-305X
Subject:
innate immunity,   etc   ; Branchiostoma belcheri; genes; phylogeny;     Show all 4 Subjects
Abstract:
... Phosphatidylinositol 4-phosphate 5-kinase (PIP5K) is a catalytic kinase that performs multiple functions in organisms. Recent studies have shown that PIP5Kα in mammals can directly participate in the TLR-mediated innate immune regulation by controlling the production of PIP2. However, the PIP5K homologous gene has not been identified in Cephalochordata to date. In this study, we firstly identify a ...
DOI:
10.1016/j.dci.2022.104430

15. Metal sequestration by S100 proteins in chemically diverse environments

Author:
Tomer Rosen; Kwo-Kwang A. Wang; Elizabeth M. Nolan
Source:
Trends in microbiology 2022 v.30 no.7 pp. 654-664
ISSN:
0966-842X
Subject:
innate immunity,   etc   ; antimicrobial properties; extracellular space; mammals;     Show all 4 Subjects
Abstract:
... During infection, the mammalian host initiates a metal-withholding response against invading microbial pathogens to inhibit their growth and survival, a process often termed ‘nutritional immunity’. The host-defense S100 proteins calprotectin (CP) (S100A8/S100A9 oligomer), S100A12, and S100A7 play key roles in the innate immune response by sequestrating essential transition metal nutrients from mic ...
DOI:
10.1016/j.tim.2021.12.006

16. Activation and Evasion of Innate Immunity by Gammaherpesviruses

Author:
Philip T. Lange; Maria C. White; Blossom Damania
Source:
Journal of molecular biology 2022 v.434 no.6 pp. 167214
ISSN:
0022-2836
Subject:
innate immunity,   etc   ; Gammaherpesvirinae; humans; molecular biology; therapeutics;     Show all 5 Subjects
Abstract:
... Gammaherpesviruses are ubiquitous pathogens that establish lifelong infections in the vast majority of adults worldwide. Importantly, these viruses are associated with numerous malignancies and are responsible for significant human cancer burden. These virus-associated cancers are due, in part, to the ability of gammaherpesviruses to successfully evade the innate immune response throughout the cou ...
DOI:
10.1016/j.jmb.2021.167214

17. A simple, robust flow cytometry-based whole blood assay for investigating sex differential interferon alpha production by plasmacytoid dendritic cells

Author:
Oliver Sampson; Nicholas Lim; Jemima White; Vinicius Vieira; Henrik Kløverpris; Emily Adland; Chris Conlon; Donal Skelly; Lucy Jones; Lizzie Stafford; Anni Jamsen; Ellie Barnes; Susie Dunachie; John Frater; Paul Klenerman; Marcus Altfeld; Philip Goulder
Source:
Journal of immunological methods 2022 v.504 pp. 113263
ISSN:
0022-1759
Subject:
innate immunity,   etc   ; blood; cryopreservation; cytokines; immune response; vaccination;     Show all 6 Subjects
Abstract:
... Central to sex differences observed in outcome from infection and vaccination is the innate immune response, and specifically production of type I interferons by plasmacytoid dendtiric cells (pDCs), the main producers of IFN-α. Evaluation of IFN-α production by pDCs is therefore critical for studies of innate immune function. However, reliable measurement of pDC IFN-α is hampered by reduced cell y ...
DOI:
10.1016/j.jim.2022.113263

18. Trained immunity against diseases in domestic animals

Author:
Miriam Angulo; Carlos Angulo
Source:
Acta tropica 2022 v.229 pp. 106361
ISSN:
0001-706X
Subject:
innate immunity,   etc   ; biotechnology; humans; mice; research and development;     Show all 5 Subjects
Abstract:
... Trained immunity is a biological concept that has been demonstrated in different animal species, including human beings. Evidences indicate that innate immune cells can be trained and have a “memory”. Under this concept, studies have shown that a first stimulus can potentiate immune responses upon a second one or protect upon homologous or heterologous pathogenic challenges. Research progress on t ...
DOI:
10.1016/j.actatropica.2022.106361

19. TLR9: A friend or a foe

Author:
Mona M. Saber; Nada Monir; Azza S. Awad; Marwa E. Elsherbiny; Hala F. Zaki
Source:
Life sciences 2022 v.307 pp. 120874
ISSN:
0024-3205
Subject:
innate immunity,   etc   ; homeostasis; immune system; inflammation; nucleotides; therapeutics;     Show all 6 Subjects
Abstract:
... The innate immune system is a primary protective line in our body. It confers its protection through different pattern recognition receptors (PRRs), especially toll like receptors (TLRs). Toll like receptor 9 (TLR9) is an intracellular TLR, expressed in different immunological and non-immunological cells. Release of cellular components, such as proteins, nucleotides, and DNA confers a beneficial i ...
DOI:
10.1016/j.lfs.2022.120874

20. RNAi-Based Antiviral Innate Immunity in Plants

Author:
Liying Jin; Mengna Chen; Meiqin Xiang; Zhongxin Guo
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
innate immunity,   etc   ; Arabidopsis; RNA; RNA interference; eukaryotic cells; viruses;     Show all 6 Subjects
Abstract:
... Multiple antiviral immunities were developed to defend against viral infection in hosts. RNA interference (RNAi)-based antiviral innate immunity is evolutionarily conserved in eukaryotes and plays a vital role against all types of viruses. During the arms race between the host and virus, many viruses evolve viral suppressors of RNA silencing (VSRs) to inhibit antiviral innate immunity. Here, we re ...
DOI:
10.3390/v14020432