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1. Natural pigments of plant origin: Classification, extraction and application in foods

Author:
Azucena Rodríguez-Mena; Luz Araceli Ochoa-Martínez; Silvia Marina González-Herrera; Olga Miriam Rutiaga-Quiñones; Rubén Francisco González-Laredo; Begoña Olmedilla-Alonso
Source:
Food chemistry 2023 v.398 pp. 133908
ISSN:
0308-8146
Subject:
insulin-dependent diabetes mellitus,   etc   ; anthocyanins; betalains; carotenoids; color; encapsulation; food chemistry; obesity; risk reduction;     Show all 9 Subjects
Abstract:
... Color is the first attribute that influences the acceptance of foods as they become more attractive to consumers when they are more intense and uniform. In recent years, the interest of producers and consumers in purchasing products containing natural ingredients have constantly increased. Natural pigments are commonly extracted from fruits and vegetables, and have been proven to provide health be ...
DOI:
10.1016/j.foodchem.2022.133908

2. Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221

Author:
Jie Yang; Zi-Xuan Wang; Lei Fang; Tu-Shuai Li; Zhi-Hong Liu; Ying Pan; Ling-Dong Kong
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115688
ISSN:
0378-8741
Subject:
insulin; insulin resistance,   etc   ; Atractylodes lancea; Magnolia officinalis; Oriental traditional medicine; Western blotting; adiponectin receptors; agonists; animal models; diet; fluorescent antibody technique; fructose; humans; kidneys; liquid chromatography; non-specific serine/threonine protein kinase; pharmacology; rats; tandem mass spectrometry; therapeutics; thermosensitivity;     Show all 21 Subjects
Abstract:
... In traditional Chinese medicine, a long term of improper diet causes the Dampness and disturbs Zang-Fu's functions including Kidney deficiency. Atractylodes lancea (Atr) and Magnolia officinalis (Mag) as a famous herb pair are commonly used to transform Dampness, with kidney protection. To explore how Atr and Mag protected against insulin signaling impairment in glomerular podocytes induced by hig ...
DOI:
10.1016/j.jep.2022.115688

3. Bayesian joint modeling for causal mediation analysis with a binary outcome and a binary mediator: Exploring the role of obesity in the association between cranial radiation therapy for childhood acute lymphoblastic leukemia treatment and the long-term risk of insulin resistance

Author:
Miguel Caubet; Mariia Samoilenko; Simon Drouin; Daniel Sinnett; Maja Krajinovic; Caroline Laverdière; Valérie Marcil; Geneviève Lefebvre
Source:
Computational statistics & data analysis 2023 v.177 pp. 107586
ISSN:
0167-9473
Subject:
insulin resistance,   etc   ; Bayesian theory; childhood; data analysis; lymphocytic leukemia; models; obesity; radiotherapy; regression analysis; relative risk; sample size;     Show all 11 Subjects
Abstract:
... Mediation analysis with a binary outcome is notoriously more challenging than with a continuous outcome. A new Bayesian approach for performing causal mediation with a binary outcome and a binary mediator, named the t-link approach, is introduced. This approach relies on the Bayesian multivariate logistic regression model introduced by O'Brien and Dunson (2004) and its Student-t approximation. By ...
DOI:
10.1016/j.csda.2022.107586

4. The growth performance, antioxidative status and muscle quality of grass carp (Ctenopharyngodon idellus) cultured in the recirculating pond aquaculture system (RPAS)

Author:
Weitong Xu; Qiushi Yang; Yin Wang; Rong Tang; Dapeng Li
Source:
Aquaculture 2023 v.562 pp. 738829
ISSN:
0044-8486
Subject:
insulin-like growth factor I; insulin-like growth factor II,   etc   ; Ctenopharyngodon idella; ammonium nitrogen; animal growth; aquaculture; aquatic plants; aspartic acid; blood serum; feed conversion; fish; genes; glutamic acid; growth performance; histology; liver; malondialdehyde; muscles; myogenin; nitrate nitrogen; oxidative stress; somatotropin receptors; texture; umami; water quality;     Show all 25 Subjects
Abstract:
... The recirculating pond aquaculture system (RPAS) consisted of culture ponds, a purification pond, inflow ditch, outflow pipe, ecological ditch, and electrically driven pump. The performance of RPAS on grass carp (Ctenopharyngodon idellus) was explored in this study. In both the RPAS and the traditional pond aquaculture system (TPAS), water quality, fish growth performance, muscle quality, and tiss ...
DOI:
10.1016/j.aquaculture.2022.738829

5. Sucrose-induced abiotic stress improves the phytochemical profiles and bioactivities of mung bean sprouts

Author:
Jaeeun Yu; Hana Lee; Huijin Heo; Heon Sang Jeong; Jeehye Sung; Junsoo Lee
Source:
Food chemistry 2023 v.400 pp. 134069
ISSN:
0308-8146
Subject:
insulin resistance,   etc   ; abiotic stress; antioxidants; chemical constituents of plants; elicitors; flavonoids; food chemistry; mung beans; nutritive value; oxidative toxicity; phytosterols; polyphenols; sucrose;     Show all 13 Subjects
Abstract:
... This study aimed to examine the impact of sucrose treatment on the growth conditions, dietary nutritional quality, and biological activities of mung bean sprouts. Mung bean seeds were sprouted with solutions containing different sucrose concentrations (10, 20, and 30 g/L). The application of exogenous sucrose significantly decreased the height and fresh weight of mung bean sprouts. However, the su ...
DOI:
10.1016/j.foodchem.2022.134069

6. Interaction of temperature and feed ration on male postsmolt maturation of Atlantic salmon (Salmo salar L.)

Author:
Enrique Pino Martinez; Pablo Balseiro; Sigurd O. Stefansson; Nobuto Kaneko; Birgitta Norberg; Mitchell S. Fleming; Albert K.D. Imsland; Sigurd O. Handeland
Source:
Aquaculture 2023 v.562 pp. 738877
ISSN:
0044-8486
Subject:
insulin-like growth factor I,   etc   ; Salmo salar; adenosinetriphosphatase; aquaculture; early development; genes; gonadosomatic index; life history; males; parr; photoperiod; restricted feeding; risk; salmon; seawater; smoltification; temperature;     Show all 17 Subjects
Abstract:
... Early maturation of Atlantic salmon male postsmolts is undesirable in aquaculture due to its negative impact on growth, welfare and seawater adaptation, however it is an increasing problem under intensive rearing conditions. The effect of temperature and feeding ration on sexual maturation during the induction of smoltification was tested with a 3 × 2 factorial design including three temperatures ...
DOI:
10.1016/j.aquaculture.2022.738877

7. Characterization of antidiabetic effects of Dendrobium officinale derivatives in a mouse model of type 2 diabetes mellitus

Author:
Dong Peng; Wenni Tian; Miaoqing An; Yanlan Chen; Wenshen Zeng; Siyang Zhu; Pan Li; Bing Du
Source:
Food chemistry 2023 v.399 pp. 133974
ISSN:
0308-8146
Subject:
insulin resistance,   etc   ; Dendrobium officinale; blood lipids; dietary supplements; digestive system; dysbiosis; food chemistry; glucomannans; glucose; histopathology; lipid metabolism; metformin; mice; microorganisms; molecular weight; noninsulin-dependent diabetes mellitus; oxidative stress;     Show all 17 Subjects
Abstract:
... In this research, two sequential Dendrobium officinale water extracts (WDOE and WDOP1) were shown to significantly ameliorate type 2 diabetic mellitus (T2DM) in a mouse model. WDOP1 was identified as a glucomannan with a backbone of 1,4-linked Manp and 1,4-linked Glcp and an average molecular weight of 731 kDa. We also found that both WDOE and WDOP1 could significantly alleviate glucose intoleranc ...
DOI:
10.1016/j.foodchem.2022.133974

8. Sex difference in effects of intermittent heat exposure on hepatic lipid and glucose metabolisms

Author:
Guoqing Zhang; Yindan Wang; Ran Li; Jing Peng; Jinna Zhang; Renjie Hu; Lu Zhang; Yunlu Wu; Qinghua Sun; Cuiqing Liu
Source:
Science of the total environment 2023 v.854 pp. 158704
ISSN:
0048-9697
Subject:
insulin resistance,   etc   ; beta oxidation; body weight; climate; environment; exports; fatty acids; females; free fatty acids; glucose; glucose tolerance; glycolysis; heat; heat-shock protein 70; homeostasis; lipolysis; liver; males; mitochondria; triacylglycerols;     Show all 20 Subjects
Abstract:
... Global climate warming has drawn worldwide attention. However, the health impact of heat exposure is still controversial. This study aimed to explore the exact effects and sex differential vulnerability under intermittent heat exposure (IHE) patterns and tried to elucidate the potential mechanisms by which IHE modulated hepatic lipid and glucose homeostasis. Both female and male C57BL/6 N mice wer ...
DOI:
10.1016/j.scitotenv.2022.158704

9. Stereoselective metabolic disruption of cypermethrin by remolding gut homeostasis in rat

Author:
Quan Zhang; Sijia Gu; Yan Wang; Shitao Hu; Siqing Yue; Cui Wang
Source:
Journal of environmental sciences (China) 2023 v.126 pp. 761-771
ISSN:
1001-0742
Subject:
insulin resistance,   etc   ; Elusimicrobia; Firmicutes; Verrucomicrobia; blood glucose; body weight; cypermethrin; digestive system; energy; glycogen; glycolipids; homeostasis; hyperlipidemia; inflammation; intestinal microorganisms; phenotype; probiotics; pyrethrins; rats; species diversity; stereoselectivity; triacylglycerols; weight loss; China;     Show all 24 Subjects
Abstract:
... Cypermethrin (CYP), a prototypical synthetic pyrethroid, reportedly causes metabolic disruption, while its stereoselective impact remains elusive. This study initially revealed that only α-CYP caused significant weight loss at 8.5 mg/(kg•day) in rats. All three CYP isomers caused the accumulation of hepatic glycogen, and hyperlipemia phenotype as the increment of total triglyceride. Rats treated w ...
DOI:
10.1016/j.jes.2022.03.035

10. Cloning, prokaryotic expression, purification, and functional verification of the insulin gene in black carp (Mylopharyngodon piceus)

Author:
Jiahua Zhang; Yubang Shen; Yafan Dai; Xiaoyan Xu; Yuhong Su; Jiale Li
Source:
Aquaculture and fisheries 2023 v.8 no.1 pp. 18-25
ISSN:
2468-550X
Subject:
insulin,   etc   ; Mylopharyngodon piceus; aquaculture; blood; brain; cell membranes; cell nucleus; fatty-acid synthase; gene expression; genes; glucose-6-phosphatase; glycogen; hybridization; liver; metabolism; molecular weight; muscle tissues; phosphatidylinositol 3-kinase; phosphorylase; somatotropin;     Show all 20 Subjects
Abstract:
... In this paper, we studied the structure, expression and function of black carp insulin gene. The complete Mylopharyngodon piceus insulin (Mp-Ins) gene is 1,965 bp long and includes a 1,499 bp 5ʹ-untranslated region (UTR), a 139 bp 3′-UTR with a poly(A) tail, and an open reading frame (ORF) of 327 bp. The predicted molecular weight of the recombinant Mp-Ins(rMp-Ins) protein is 11.87 kDa. The mRNA e ...
DOI:
10.1016/j.aaf.2021.03.005

11. Combining LC-MS/MS profiles with network pharmacology to predict molecular mechanisms of the hyperlipidemic activity of Lagenaria siceraria stand

Author:
Subhadip Banerjee; Amrendra Tiwari; Amit Kar; Joydeb Chanda; Sayan Biswas; Gudrun Ulrich-Merzenich; Pulok K. Mukherjee
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115633
ISSN:
0378-8741
Subject:
insulin,   etc   ; Ayurvedic medicine; Lagenaria siceraria; albino; alcohols; animals; atorvastatin; bioinformatics; computer simulation; ferulic acid; food plants; hesperidin; high fat diet; hyperlipidemia; hypertension; lipids; mechanism of action; metabolites; obesity; p-coumaric acid; pharmacology;     Show all 21 Subjects
Abstract:
... Lagenaria siceraria Stand. (Family: Cucurbitaceae), popularly known as bottle gourd, is traditionally used in Ayurvedic medicine as a food plant, especially in hypertension and obesity. Investigations were undertaken to assign novel lead combinations from this common food plant to multi-molecular modes of actions in the complex disease networks of obesity and hypertension. LC–MS/MS based metabolit ...
DOI:
10.1016/j.jep.2022.115633

12. Integrated serum pharmacochemistry and network pharmacology analyses reveal the bioactive metabolites and potential functional mechanism of ground cherry (Physalis pruinosa L.) in treatment of type 2 diabetes mellitus in rats

Author:
Asmaa Mahana; Hala M. Hammoda; Asmaa A. Khalifa; Samar S. Elblehi; Fathallah M. Harraz; Eman Shawky
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115750
ISSN:
0378-8741
Subject:
insulin,   etc   ; Physalis pruinosa; atherosclerosis; blood serum; calyx; cherries; gene ontology; genome; glucose; glycemic effect; high fat diet; histopathology; immunoblotting; lipid metabolism; lipids; mechanism of action; metabolites; models; noninsulin-dependent diabetes mellitus; pharmacology; quercetin; rats; streptozotocin; traditional medicine;     Show all 24 Subjects
Abstract:
... Different Physalis plants have been widely employed in traditional medicine for management of diabetes mellitus. Previous studies with respect to the in vivo antidiabetic activity of Physalis plants illustrated that they improved glucose and lipid metabolism in streptozotocin (STZ) -induced diabetic rats yet the mechanism of action of bioactive constituents of the different organs of Physalis plan ...
DOI:
10.1016/j.jep.2022.115750

13. Dietary fiber konjac glucomannan exerts an antidiabetic effect via inhibiting lipid absorption and regulation of PPAR-γ and gut microbiome

Author:
Muthukumaran Jayachandran; Sunil Christudas; Xuchu Zheng; Baojun Xu
Source:
Food chemistry 2023 v.403 pp. 134336
ISSN:
0308-8146
Subject:
insulin,   etc   ; absorption; blood lipids; body weight; dietary fiber; drugs; fibrosis; food chemistry; glycemic effect; high fat diet; hyperlipidemia; immunohistochemistry; intestinal microorganisms; konjac mannan; lipid composition; lipid metabolism; lipids; liver; microbiome; noninsulin-dependent diabetes mellitus; protein synthesis; streptozotocin;     Show all 22 Subjects
Abstract:
... Konjac glucomannan’s influence on the regulation of diabetes mellitus, hyperlipidemia, and gut microbial flora was evaluated in this study. In addition, a high-fat diet and streptozotocin were used to induce type 2 diabetes mellitus in rats. At the end of the study, we analyzed various parameters such as body weight, plasma lipid profile, insulin levels by immunohistochemistry, degree of fibrosis ...
DOI:
10.1016/j.foodchem.2022.134336

14. Effects of apolipoprotein E on regulating insulin sensitivity via regulating insulin receptor signalosome in caveolae

Author:
Miao Liu; Man-Yun Chen; Liang An; Si-Qing Ma; Jie Mei; Wei-Hua Huang; Wei Zhang
Source:
Life sciences 2022 v.308 pp. 120929
ISSN:
0024-3205
Subject:
insulin; insulin receptors; insulin resistance,   etc   ; apolipoprotein E; glucose; glucose transporters; liver; pathogenesis; signalosome;     Show all 9 Subjects
Abstract:
... Although impaired insulin signaling at a post-receptor level was a well-established key driver of insulin resistance, the role of surface abnormal insulin receptor (INSR) location in insulin resistance pathogenesis tended to be ignored and its molecular mechanisms remained obscure. Herein, this study aimed to investigate hepatic apolipoprotein E (APOE) impaired cellular insulin action via reducing ...
DOI:
10.1016/j.lfs.2022.120929

15. Impact of Diet Composition on Insulin Resistance

Author:
Fátima O. Martins; Silvia V. Conde
Source:
Nutrients 2022 v.14 no.18 pp. -
ISSN:
2072-6643
Subject:
insulin; insulin resistance,   etc   ; blood glucose; diet; pancreas;     Show all 5 Subjects
Abstract:
... Insulin resistance is a complex condition in which the body does not respond adequately to insulin, a hormone secreted by the pancreas with an essential role in the regulation of blood sugar levels [...] ...
DOI:
10.3390/nu14183716

16. The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion

Author:
Mitsuaki Sobajima; Masato Miyake; Yoshimasa Hamada; Kazue Tsugawa; Miho Oyadomari; Ryota Inoue; Jun Shirakawa; Hiroshi Arima; Seiichi Oyadomari
Source:
Biochemical and biophysical research communications 2022 v.611 pp. 165-171
ISSN:
0006-291X
Subject:
insulin; insulin secretion,   etc   ; glucose; research; transcription factors;     Show all 5 Subjects
Abstract:
... Stress-inducible transcription factor ATF4 is essential for survival and identity of β-cell during stress conditions. However, the physiological role of ATF4 in β-cell function is not yet completely understood. To understand the role of ATF4 in glucose-stimulated insulin secretion (GSIS), β-cell-specific Atf4 knockout (βAtf4KO) mice were phenotypically characterized. Insulin secretion and mechanis ...
DOI:
10.1016/j.bbrc.2022.04.038

17. The crucial role of thioredoxin interacting protein in the liver insulin resistance induced by di (2-ethylhexyl) phthalates

Author:
Wang Zhang; Peng Xu; Jing-ya Li
Source:
Food and chemical toxicology 2022 v.164 pp. 113045
ISSN:
0278-6915
Subject:
insulin; insulin receptor substrate proteins; insulin receptors,   etc   ; genomics; glucose transporters; humans; insulin resistance; liver; oxidative stress; phthalates; protein synthesis; proteomics; thioredoxins; toxicology; verapamil;     Show all 15 Subjects
Abstract:
... The widespread usage of plastic products in human life has led to extensive exposure to plasticizers and resulted in serious health problems for humans, which has become a focus of toxicology research in the world. We aimed to explore the potential mechanism of liver insulin resistance induced by di(2-ethylhexyl) phthalate (DEHP) and working on a novel treatment to alleviate insulin resistance cau ...
DOI:
10.1016/j.fct.2022.113045

18. Integrated multiple-omics reveals the regulatory mechanism underlying the effects of artificial feed and grass feeding on growth and muscle quality of grass carp (Ctenopharyngodon idellus)

Author:
Honghao Zhao; Jasmine Chong; Dapeng Li; Jianguo Xia
Source:
Aquaculture 2023 v.562 pp. 738808
ISSN:
0044-8486
Subject:
insulin resistance,   etc   ; Ctenopharyngodon idella; aquaculture; beta oxidation; cell proliferation; droplets; farmed fish; flavor; glycogen; glycolysis; grasses; hypertrophy; lipids; muscle fibers; muscles; necroptosis; peroxisome proliferator-activated receptor alpha; phosphatidylinositol 3-kinase; protein synthesis; proteolysis; proteomics; stress tolerance; texture; transcriptomics; tricarboxylic acid cycle; ubiquitin;     Show all 26 Subjects
Abstract:
... The muscle quality of farmed fish has attracted widespread public attention. To understand a comprehensive molecular mechanism underlying the effects of artificial formula feed- (AF) and grass-feeding (GF) on muscle quality and growth of grass carp (Ctenopharyngodon idellus), muscular transcriptomics and proteomics of GF and AF C. idellus were characterized. A total of 834 DEGs (484 up-, 350 down- ...
DOI:
10.1016/j.aquaculture.2022.738808

19. Does creatine supplementation improve glycemic control and insulin resistance in healthy and diabetic patients? A systematic review and meta-analysis

Author:
Felipe Mendes Delpino; Lílian Munhoz Figueiredo
Source:
Clinical nutrition ESPEN 2022 v.47 pp. 128-134
ISSN:
2405-4577
Subject:
insulin; insulin resistance; insulin secretion,   etc   ; blood glucose; clinical nutrition; creatine; diabetes; glucose; glycemic control; meta-analysis; systematic review;     Show all 11 Subjects
Abstract:
... Creatine supplementation shows promising effects on diabetes, especially in glucose management and insulin secretion. This study aimed to review the literature on studies that evaluated the effects of creatine supplementation on parameters of diabetes in humans. We conducted a systematic review and meta-analysis, until December 2020, in the following databases: Pubmed, Lilacs, Scielo, Scopus, SPOR ...
DOI:
10.1016/j.clnesp.2021.11.006

20. Comparative proteomic analysis of insulin receptor isoform A and B signaling

Author:
Roberta Malaguarnera; Caterina Gabriele; Gianluca Santamaria; Marika Giuliano; Veronica Vella; Michele Massimino; Paolo Vigneri; Giovanni Cuda; Marco Gaspari; Antonino Belfiore
Source:
Molecular and cellular endocrinology 2022 v.557 pp. 111739
ISSN:
0303-7207
Subject:
insulin; insulin receptors,   etc   ; fibroblasts; genes; interferons; mice; neoplasms; physiology; proteomics;     Show all 9 Subjects
Abstract:
... The insulin receptor (IR) gene undergoes differential splicing generating two IR isoforms, IR-A and IR-B. The roles of IR-A in cancer and of IR-B in metabolic regulation are well known but the molecular mechanisms responsible for their different biological effects are poorly understood. We aimed to identify different or similar protein substrates and signaling linked to each IR isoforms. We employ ...
DOI:
10.1016/j.mce.2022.111739