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- Author:
- Madić, Višnja; Petrović, Aleksandra; Jušković, Marina; Jugović, Dragana; Djordjević, Ljubiša; Stojanović, Gordana; Vasiljević, Perica
- Source:
- Journal of ethnopharmacology 2021 v.265 pp. 113210
- ISSN:
- 0378-8741
- Subject:
- insulin-dependent diabetes mellitus, etc ; 2,2-diphenyl-1-picrylhydrazyl; Geum urbanum; Phaseolus vulgaris; Potentilla erecta; Rubus plicatus; Vaccinium myrtillus; aerial parts; alloxan; animal models; antioxidant activity; blood glucose; caftaric acid; chemical constituents of plants; cholesterol; females; gallic acid; hepatoprotective effect; high performance liquid chromatography; histopathology; hyperglycemia; hyperlipidemia; insulin; intraperitoneal injection; kidneys; laboratory animals; leaves; lipid composition; liver; low density lipoprotein; metformin; nephroprotective effect; pancreas; quercitrin; quinic acid; rats; roots; rutin; staining; toxicity; traditional medicine; triacylglycerols; very low density lipoprotein; Show all 43 Subjects
- Abstract:
- ... One of the commonly prescribed ‘anti-diabetic’ polyherbal mixtures by European herbalists is made of Rubus fruticosus and Vaccinium myrtillus leaves, Potentilla erecta roots, Geum urbanum aerial parts and Phaseolus vulgaris pods.This study aimed to evaluate the phytochemical composition, antioxidant capacity, potential toxicity, hypoglycemic, hypolipidemic, nephroprotective and hepatoprotective ac ...
- DOI:
- 10.1016/j.jep.2020.113210
-
https://dx.doi.org/10.1016/j.jep.2020.113210
- Author:
- Jacobs, Peter G.; Tyler, Nichole S.; Vanderwerf, Scott M.; Mosquera-Lopez, Clara; Seidl, Thomas; Cargill, Robert; Branigan, Deborah; Ramsey, Katrina; Morris, Kristin; Benware, Sheila; Ward, W. Kenneth; Castle, Jessica R.
- Source:
- Biosensors & bioelectronics 2020 v.165 pp. 112221
- ISSN:
- 0956-5663
- Subject:
- insulin-dependent diabetes mellitus, etc ; algorithms; automation; biosensors; cannulas; glucose; insulin; people; phosphates; Show all 9 Subjects
- Abstract:
- ... Automated insulin delivery systems for people with type 1 diabetes rely on an accurate subcutaneous glucose sensor and an infusion cannula that delivers insulin in response to measured glucose. Integrating the sensor with the infusion cannula would provide substantial benefit by reducing the number of devices inserted into subcutaneous tissue. We describe the sensor chemistry and a calibration alg ...
- DOI:
- 10.1016/j.bios.2020.112221
-
https://dx.doi.org/10.1016/j.bios.2020.112221
- Author:
- Mine, Keiichiro; Yoshikai, Yasunobu; Takahashi, Hirokazu; Mori, Hitoe; Anzai, Keizo; Nagafuchi, Seiho
- Source:
- Microorganisms 2020 v.8 no.8
- ISSN:
- 2076-2607
- Subject:
- insulin-dependent diabetes mellitus, etc ; Enterovirus; animal models; autoimmunity; environmental factors; genes; genetic factors; humans; viruses; Show all 9 Subjects
- Abstract:
- ... Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic sus ...
- DOI:
- 10.3390/microorganisms8081133
-
http://dx.doi.org/10.3390/microorganisms8081133
- Author:
- Griggs, Stephanie; Whittemore, Robin; Redeker, Nancy S.; Grey, Margaret
- Source:
- TheDiabetes educator 2020 v.46 no.3 pp. 242-251
- ISSN:
- 1554-6063
- Subject:
- insulin-dependent diabetes mellitus, etc ; diabetes educators; disease control; electronic equipment; females; interviews; sleep; young adults; Show all 8 Subjects
- Abstract:
- ... The purpose of this study was to explore the perceived facilitators and barriers for obtaining sufficient sleep in young adults with type 1 diabetes (T1D). A qualitative descriptive approach was used to generate data. In-depth semi-structured interviews with 30 young adults with T1D (66.7% female, mean age = 22.1 years) were conducted. Interviews were transcribed verbatim and coded using NVivo. Yo ...
- DOI:
- 10.1177/0145721720916179
-
http://dx.doi.org/10.1177/0145721720916179
- Author:
- Magisson, Jordan; Sassi, Aladin; Kobalyan, Aram; Burcez, Charles-Thibault; Bouaoun, Richard; Vix, Michel; Jeandidier, Nathalie; Sigrist, Severine
- Source:
- Journal of controlled release 2020 v.320 pp. 431-441
- ISSN:
- 0168-3659
- Subject:
- insulin-dependent diabetes mellitus, etc ; animal disease models; blood glucose; catheters; insulin; intraperitoneal injection; landraces; pharmacokinetics; Show all 8 Subjects
- Abstract:
- ... Intraperitoneal insulin delivery has higher benefits than subcutaneous insulin administration but has limitations, including obstruction of the catheter used in delivery devices. To overcome these limitations this study assessed safety and efficacy of an alternative approach involving a new delivery device, named ExOlin®, allowing diffuse release of insulin in the extraperitoneal site. The aim of ...
- DOI:
- 10.1016/j.jconrel.2020.01.055
-
https://dx.doi.org/10.1016/j.jconrel.2020.01.055
- Author:
- Sullivan-Bolyai, Susan; Bova, Carol; Johnson, Kimberly
- Source:
- TheDiabetes educator 2020 v.46 no.2 pp. 191-196
- ISSN:
- 1554-6063
- Subject:
- insulin-dependent diabetes mellitus, etc ; children; cognition; diabetes educators; factor analysis; parents; social support; variance; youth; Show all 9 Subjects
- Abstract:
- ... The purpose of this study was to develop and evaluate the psychometric properties of the Peer-Mentor Support Scale (PMSS), a measure of peer-mentor support provided to parents of children with type 1 diabetes (T1D) and to youths with T1D. A multistage process was undertaken to include the following: item construction based on qualitive data from those who have experienced peer-mentor support, cogn ...
- DOI:
- 10.1177/0145721720907055
-
http://dx.doi.org/10.1177/0145721720907055
- Author:
- Treff, Nathan R.; Eccles, Jennifer; Marin, Diego; Messick, Edward; Lello, Louis; Gerber, Jessalyn; Xu, Jia; Tellier, Laurent C.A.M.
- Source:
- Genes 2020 v.11 no.6
- ISSN:
- 2073-4425
- Subject:
- insulin-dependent diabetes mellitus, etc ; adults; disease incidence; genomics; genotype; heart diseases; neoplasms; patients; relative risk; risk reduction; siblings; Show all 11 Subjects
- Abstract:
- ... Preimplantation genetic testing for polygenic disease risk (PGT-P) represents a new tool to aid in embryo selection. Previous studies demonstrated the ability to obtain necessary genotypes in the embryo with accuracy equivalent to in adults. When applied to select adult siblings with known type I diabetes status, a reduction in disease incidence of 45–72% compared to random selection was achieved. ...
- DOI:
- 10.3390/genes11060648
-
http://dx.doi.org/10.3390/genes11060648
- Author:
- Kaya, N.; Kurtoğlu, S.; Gökmen Özel, H.
- Source:
- Journal of human nutrition and dietetics 2020 v.33 no.3 pp. 396-403
- ISSN:
- 0952-3871
- Subject:
- insulin-dependent diabetes mellitus, etc ; adolescents; blood glucose; glucose; insulin; insulin replacement therapy; patients; randomized clinical trials; test meals; Show all 9 Subjects
- Abstract:
- ... BACKGROUND: The present study investigated the effects of fat‐protein (CFP) counting in addition to carbohydrate (CARB) counting for calculating prandial insulin dosage on blood glucose profile in patients with type 1 diabetes (T1D) on basal‐bolus insulin therapy. METHODS: In this single centre, cross‐over, randomised, controlled study, control meal (SM: standard meal using a carbohydrate counting ...
- DOI:
- 10.1111/jhn.12711
-
http://dx.doi.org/10.1111/jhn.12711
- Author:
- Henze, Martha M.; Bemis, Elizabeth A.; Seifert, Jennifer A.; Johnson, Randi K.; Dong, Fran; Rewers, Marian; Norris, Jill M.
- ISSN:
- 2048-6790
- Subject:
- insulin-dependent diabetes mellitus, etc ; added sugars; biomarkers; carbon; children; compliance; dietary carbohydrate; erythrocytes; nitrogen; risk; stable isotopes; Colorado; Show all 12 Subjects
- Abstract:
- ... We examined whether change in added sugar intake is associated with change in δ¹³C, a novel sugar biomarker, in thirty-nine children aged 5–10 years selected from a Colorado (USA) prospective cohort of children at increased risk for type 1 diabetes. Reported added sugar intake via FFQ and δ¹³C in erythrocytes were measured at two time points a median of 2 years apart. Change in added sugar intake ...
- DOI:
- 10.1017/jns.2020.9
-
http://dx.doi.org/10.1017/jns.2020.9
- Author:
- Wessels, Inga; Rink, Lothar
- Source:
- The Journal of nutritional biochemistry 2020 v.77 pp. 108240
- ISSN:
- 0955-2863
- Subject:
- insulin-dependent diabetes mellitus, etc ; Crohn disease; cost effectiveness; immune response; immune system; pathogens; rheumatoid arthritis; sclerosis; therapeutics; vitamin D; zinc; Show all 11 Subjects
- Abstract:
- ... A functional immune system is essential for healthy life. This is achieved by the coordinate activation and interaction of different immune cells. One should be aware that activation of the immune response is as important as its deactivation when the pathogens are cleared, as otherwise host tissue can be damaged up to life-threatening levels.Autoimmune diseases (AID) represent a phenomenon of immu ...
- DOI:
- 10.1016/j.jnutbio.2019.108240
-
https://dx.doi.org/10.1016/j.jnutbio.2019.108240
- Author:
- Kushner, Jake A.
- Source:
- Nutrients 2019 v.11 no.11
- ISSN:
- 2072-6643
- Subject:
- insulin-dependent diabetes mellitus, etc ; athletic performance; carbohydrates; nutrients; Show all 4 Subjects
- Abstract:
- ... I read with great interest the thoughtful review concerning the potential impact of carbohydrate restriction in type 1 diabetes on glycaemic parameters and athletic performance [...] ...
- DOI:
- 10.3390/nu11112700
- PubMed:
- 31703469
- PubMed Central:
- PMC6893803
-
http://dx.doi.org/10.3390/nu11112700
- Author:
- Tang, Chun-lian; Gao, Yan-ru; Wang, Li-xia; Zhu, Ya-wen; Pan, Qun; Zhang, Rong-hui; Xiong, Ying
- Source:
- Molecular and cellular endocrinology 2019 v.491 pp. 110434
- ISSN:
- 0303-7207
- Subject:
- insulin-dependent diabetes mellitus, etc ; Schistosoma; T-lymphocytes; hygiene; parasites; pathogens; Show all 6 Subjects
- Abstract:
- ... The prevalence of T1D in developed societies is partly based on the hygiene hypothesis, that is, the loss of exposure to infectious agents accompanies the loss of immune stimuli shaping the immune system during development. Indeed, the components of parasites, such as Schistosoma, have been reported to ameliorate or prevent the development of T1D, which might be associated with immune cell activit ...
- DOI:
- 10.1016/j.mce.2019.04.014
-
https://dx.doi.org/10.1016/j.mce.2019.04.014
- Author:
- Almeida, Joana T.; Rodrigues, Dircea; Guimarães, Joana; Lemos, Manuel C.
- Source:
- Genes 2020 v.11 no.8
- ISSN:
- 2073-4425
- Subject:
- insulin-dependent diabetes mellitus, etc ; alleles; biochemical pathways; blood serum; confidence interval; disease susceptibility; gene frequency; genetic variation; genotype; hydroxylation; loci; odds ratio; patients; single nucleotide polymorphism; vitamin D; Show all 15 Subjects
- Abstract:
- ... Vitamin D has immunomodulatory effects, and its deficiency has been implicated in the autoimmune process of type 1 diabetes. Serum vitamin D levels are influenced by variants in genes involved in the synthesis, transport, hydroxylation and degradation of vitamin D. The aim of this study was to assess if single nucleotide polymorphisms (SNPs) at the DHCR7 (rs12785878), GC (rs2282679), CYP2R1 (rs206 ...
- DOI:
- 10.3390/genes11080897
-
http://dx.doi.org/10.3390/genes11080897
- Author:
- Leroux, Grégory; Neumann, Myriam; Meunier, Christophe F.; Michiels, Carine; Wang, Li; Su, Bao-Lian
- Source:
- Journal of materials science 2020 v.55 no.18 pp. 7857-7869
- ISSN:
- 0022-2461
- Subject:
- insulin-dependent diabetes mellitus, etc ; alginates; biochemical pathways; biocompatible materials; encapsulation; immunosuppression; insulin; insulin secretion; islets of Langerhans; nutrients; rats; therapeutics; titanium dioxide; Show all 13 Subjects
- Abstract:
- ... Designing biocompatible materials to encapsulate xenogeneic insulin-releasing β-cells for transplantation has been considered as a promising alternative to avoid the immunosuppression and drawbacks of the treatment of Type 1 diabetes mellitus (T1D) by direct islet transplantation. The current work for the first time studied a hybrid alginate@TiO₂ microcapsule as a reservoir for rat insulinoma-deri ...
- DOI:
- 10.1007/s10853-020-04576-9
-
https://dx.doi.org/10.1007/s10853-020-04576-9
- Author:
- Elten, Michael; Donelle, Jessy; Lima, Isac; Burnett, Richard T.; Weichenthal, Scott; Stieb, David M.; Hystad, Perry; van Donkelaar, Aaron; Chen, Hong; Paul, Lauren A.; Crighton, Eric; Martin, Randall V.; Decou, Mary Lou; Luo, Wei; Lavigne, Éric
- Source:
- Environmental research 2020 v.184 pp. 109291
- ISSN:
- 0013-9351
- Subject:
- insulin-dependent diabetes mellitus, etc ; air pollutants; air pollution; calcium; childhood; children; cohort studies; nitrogen dioxide; oxidants; ozone; particulates; pregnancy; regression analysis; Ontario; Show all 14 Subjects
- Abstract:
- ... Studies have reported increasing incidence rates of paediatric diabetes, especially among those aged 0–5 years. Epidemiological evidence linking ambient air pollution to paediatric diabetes remains mixed.This study investigated the association between maternal and early-life exposures to common air pollutants (NO₂, PM₂.₅, O₃, and oxidant capacity [Ox; the redox-weighted average of O₃ and NO₂]) and ...
- DOI:
- 10.1016/j.envres.2020.109291
-
https://dx.doi.org/10.1016/j.envres.2020.109291
- Author:
- Kumari, Yogita; Singh, Sachin Kumar; Kumar, Rajesh; Kumar, Bimlesh; Kaur, Gurmandeep; Gulati, Monica; Tewari, Devesh; Gowthamarajan, K.; Karri, V.V.S. Narayana Reddy; Ayinkamiye, Clarisse; Khursheed, Rubiya; Awasthi, Ankit; Pandey, Narendra Kumar; Mohanta, Souvik; Gupta, Saurabh; Corrie, Leander; Patni, Pooja; Kumar, Rajan; Kumar, Rakesh
- Source:
- International journal of biological macromolecules 2020 v.149 pp. 976-988
- ISSN:
- 0141-8130
- Subject:
- insulin-dependent diabetes mellitus, etc ; animal models; apples; blood glucose; body weight; creatinine; insulin; lipid composition; liver; nanogold; oral administration; polysaccharides; streptozotocin; urea; zeta potential; Show all 15 Subjects
- Abstract:
- ... The study entailed formulation of gold nanoparticles (AuNPs) upon reduction of chloroauric acid by modified apple polysaccharide (MAP). AuNPs were conjugated with insulin (INS) for its oral delivery to treat type 1 diabetes mellitus (DM). The size of MAP conjugated AuNPs loaded with INS was 124 ± 8.55 nm with zeta potential −10.5 ± 0.54 mV. The animal study carried out in streptozotocin induced ra ...
- DOI:
- 10.1016/j.ijbiomac.2020.01.302
-
https://dx.doi.org/10.1016/j.ijbiomac.2020.01.302
- Author:
- Sahinturk, Varol; Kacar, Sedat; Sahin, Erhan; Aykanat, Nuriye Ezgi Bektur
- Source:
- Life sciences 2020 v.246 pp. 117416
- ISSN:
- 0024-3205
- Subject:
- insulin-dependent diabetes mellitus, etc ; Western blotting; alanine transaminase; aspartate transaminase; blood glucose; blood sampling; blood serum; endoplasmic reticulum; endoplasmic reticulum stress; histopathology; liver; liver regeneration; males; proteins; Show all 14 Subjects
- Abstract:
- ... Diabetes is a common metabolic disease which damages many organs including the liver and causes endoplasmic reticulum (ER) stress, which originates from non-folded proteins. Sonic hedgehog (Shh) pathway plays a role in liver regeneration and repair. To our knowledge, there is no study showing the relation between ER stress and Shh pathway in the liver in diabetes. Thus, the aim of this study was t ...
- DOI:
- 10.1016/j.lfs.2020.117416
-
https://dx.doi.org/10.1016/j.lfs.2020.117416
- Author:
- Kim, Hyun-Ouk; Lee, Sang Hoon; Na, Woonsung; Lim, Jong-Woo; Park, Geunseon; Park, Chaewon; Lee, Hwunjae; Kang, Aram; Haam, Seungjoo; Choi, Inho; Kang, Jung-Taek; Song, Daesub
- Source:
- Journal of materials chemistry B 2020 v.8 no.12 pp. 2476-2482
- ISSN:
- 2050-7518
- Subject:
- insulin-dependent diabetes mellitus, etc ; autoimmunity; binding capacity; cell membranes; cell transplantation; coatings; electrostatic interactions; encapsulation; engineering; hydrogen bonding; immunosuppression; insulin secretion; nanocapsules; permeability; polyethylene glycol; swine; Show all 16 Subjects
- Abstract:
- ... Although islet cell transplantation has emerged as a promising treatment for type 1 diabetes, it remains an unmet clinical application due to the need for immunosuppression to prevent islet elimination and autoimmunity. To solve these problems, we developed novel nanoencapsulation of neonatal porcine islet-like cell clusters (NPCCs) with cell-mimic polymersomes (PSomes) based on PEG-b-PLA (poly(et ...
- DOI:
- 10.1039/c9tb02270h
-
http://dx.doi.org/10.1039/c9tb02270h
- Author:
- Kalirajan, Cheirmadurai; Palanisamy, Thanikaivelan
- Source:
- Biomaterials science 2020 v.8 no.6 pp. 1622-1637
- ISSN:
- 2047-4849
- Subject:
- insulin-dependent diabetes mellitus, etc ; albino; angiogenesis; biocompatibility; burns (injuries); collagen; crosslinking; fenugreek; granulation tissue; immunohistochemistry; oxidation; polysaccharides; rats; silica; spectral analysis; tissue repair; transforming growth factor beta 3; Show all 17 Subjects
- Abstract:
- ... The existence of diabetes and microbial infection in burn wounds makes the healing process more complex. Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica–resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection. The spectroscopic analyses of the ...
- DOI:
- 10.1039/c9bm01089k
-
http://dx.doi.org/10.1039/c9bm01089k
- Author:
- Thurmond, Debbie C.; Gaisano, Herbert Y.
- Source:
- Journal of molecular biology 2020 v.432 no.5 pp. 1310-1325
- ISSN:
- 0022-2836
- Subject:
- insulin-dependent diabetes mellitus, etc ; SNARE proteins; adults; exocytosis; glucose; insulin; islets of Langerhans; morbidity; mortality; noninsulin-dependent diabetes mellitus; United States; Show all 11 Subjects
- Abstract:
- ... As one of the leading causes of morbidity and mortality worldwide, diabetes affects an estimated 422 million adults, and it is expected to continue expanding such that by 2050, 30% of the U.S. population will become diabetic within their lifetime. Out of the estimated 422 million people currently afflicted with diabetes worldwide, about 5% have type 1 diabetes (T1D), while the remaining ~95% of di ...
- DOI:
- 10.1016/j.jmb.2019.12.012
-
https://dx.doi.org/10.1016/j.jmb.2019.12.012