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1. Polyherbal mixture ameliorates hyperglycemia, hyperlipidemia and histopathological changes of pancreas, kidney and liver in a rat model of type 1 diabetes

Author:
Madić, Višnja; Petrović, Aleksandra; Jušković, Marina; Jugović, Dragana; Djordjević, Ljubiša; Stojanović, Gordana; Vasiljević, Perica
Source:
Journal of ethnopharmacology 2021 v.265 pp. 113210
ISSN:
0378-8741
Subject:
insulin-dependent diabetes mellitus,   etc   ; 2,2-diphenyl-1-picrylhydrazyl; Geum urbanum; Phaseolus vulgaris; Potentilla erecta; Rubus plicatus; Vaccinium myrtillus; aerial parts; alloxan; animal models; antioxidant activity; blood glucose; caftaric acid; chemical constituents of plants; cholesterol; females; gallic acid; hepatoprotective effect; high performance liquid chromatography; histopathology; hyperglycemia; hyperlipidemia; insulin; intraperitoneal injection; kidneys; laboratory animals; leaves; lipid composition; liver; low density lipoprotein; metformin; nephroprotective effect; pancreas; quercitrin; quinic acid; rats; roots; rutin; staining; toxicity; traditional medicine; triacylglycerols; very low density lipoprotein;     Show all 43 Subjects
Abstract:
... One of the commonly prescribed ‘anti-diabetic’ polyherbal mixtures by European herbalists is made of Rubus fruticosus and Vaccinium myrtillus leaves, Potentilla erecta roots, Geum urbanum aerial parts and Phaseolus vulgaris pods.This study aimed to evaluate the phytochemical composition, antioxidant capacity, potential toxicity, hypoglycemic, hypolipidemic, nephroprotective and hepatoprotective ac ...
DOI:
10.1016/j.jep.2020.113210

2. Measuring glucose at the site of insulin delivery with a redox-mediated sensor

Author:
Jacobs, Peter G.; Tyler, Nichole S.; Vanderwerf, Scott M.; Mosquera-Lopez, Clara; Seidl, Thomas; Cargill, Robert; Branigan, Deborah; Ramsey, Katrina; Morris, Kristin; Benware, Sheila; Ward, W. Kenneth; Castle, Jessica R.
Source:
Biosensors & bioelectronics 2020 v.165 pp. 112221
ISSN:
0956-5663
Subject:
insulin-dependent diabetes mellitus,   etc   ; algorithms; automation; biosensors; cannulas; glucose; insulin; people; phosphates;     Show all 9 Subjects
Abstract:
... Automated insulin delivery systems for people with type 1 diabetes rely on an accurate subcutaneous glucose sensor and an infusion cannula that delivers insulin in response to measured glucose. Integrating the sensor with the infusion cannula would provide substantial benefit by reducing the number of devices inserted into subcutaneous tissue. We describe the sensor chemistry and a calibration alg ...
DOI:
10.1016/j.bios.2020.112221

3. Genetic Susceptibility of the Host in Virus-Induced Diabetes

Author:
Mine, Keiichiro; Yoshikai, Yasunobu; Takahashi, Hirokazu; Mori, Hitoe; Anzai, Keizo; Nagafuchi, Seiho
Source:
Microorganisms 2020 v.8 no.8
ISSN:
2076-2607
Subject:
insulin-dependent diabetes mellitus,   etc   ; Enterovirus; animal models; autoimmunity; environmental factors; genes; genetic factors; humans; viruses;     Show all 9 Subjects
Abstract:
... Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic sus ...
DOI:
10.3390/microorganisms8081133

4. Facilitators and Barriers of Sleep in Young Adults With Type 1 Diabetes

Author:
Griggs, Stephanie; Whittemore, Robin; Redeker, Nancy S.; Grey, Margaret
Source:
TheDiabetes educator 2020 v.46 no.3 pp. 242-251
ISSN:
1554-6063
Subject:
insulin-dependent diabetes mellitus,   etc   ; diabetes educators; disease control; electronic equipment; females; interviews; sleep; young adults;     Show all 8 Subjects
Abstract:
... The purpose of this study was to explore the perceived facilitators and barriers for obtaining sufficient sleep in young adults with type 1 diabetes (T1D). A qualitative descriptive approach was used to generate data. In-depth semi-structured interviews with 30 young adults with T1D (66.7% female, mean age = 22.1 years) were conducted. Interviews were transcribed verbatim and coded using NVivo. Yo ...
DOI:
10.1177/0145721720916179

5. A fully implantable device for diffuse insulin delivery at extraperitoneal site for physiological treatment of type 1 diabetes

Author:
Magisson, Jordan; Sassi, Aladin; Kobalyan, Aram; Burcez, Charles-Thibault; Bouaoun, Richard; Vix, Michel; Jeandidier, Nathalie; Sigrist, Severine
Source:
Journal of controlled release 2020 v.320 pp. 431-441
ISSN:
0168-3659
Subject:
insulin-dependent diabetes mellitus,   etc   ; animal disease models; blood glucose; catheters; insulin; intraperitoneal injection; landraces; pharmacokinetics;     Show all 8 Subjects
Abstract:
... Intraperitoneal insulin delivery has higher benefits than subcutaneous insulin administration but has limitations, including obstruction of the catheter used in delivery devices. To overcome these limitations this study assessed safety and efficacy of an alternative approach involving a new delivery device, named ExOlin®, allowing diffuse release of insulin in the extraperitoneal site. The aim of ...
DOI:
10.1016/j.jconrel.2020.01.055

6. Development and Psychometric Testing of the Peer-Mentor Support Scale for Parents of Children With Type 1 Diabetes and for Youths With Type 1 Diabetes

Author:
Sullivan-Bolyai, Susan; Bova, Carol; Johnson, Kimberly
Source:
TheDiabetes educator 2020 v.46 no.2 pp. 191-196
ISSN:
1554-6063
Subject:
insulin-dependent diabetes mellitus,   etc   ; children; cognition; diabetes educators; factor analysis; parents; social support; variance; youth;     Show all 9 Subjects
Abstract:
... The purpose of this study was to develop and evaluate the psychometric properties of the Peer-Mentor Support Scale (PMSS), a measure of peer-mentor support provided to parents of children with type 1 diabetes (T1D) and to youths with T1D. A multistage process was undertaken to include the following: item construction based on qualitive data from those who have experienced peer-mentor support, cogn ...
DOI:
10.1177/0145721720907055

7. Preimplantation Genetic Testing for Polygenic Disease Relative Risk Reduction: Evaluation of Genomic Index Performance in 11,883 Adult Sibling Pairs

Author:
Treff, Nathan R.; Eccles, Jennifer; Marin, Diego; Messick, Edward; Lello, Louis; Gerber, Jessalyn; Xu, Jia; Tellier, Laurent C.A.M.
Source:
Genes 2020 v.11 no.6
ISSN:
2073-4425
Subject:
insulin-dependent diabetes mellitus,   etc   ; adults; disease incidence; genomics; genotype; heart diseases; neoplasms; patients; relative risk; risk reduction; siblings;     Show all 11 Subjects
Abstract:
... Preimplantation genetic testing for polygenic disease risk (PGT-P) represents a new tool to aid in embryo selection. Previous studies demonstrated the ability to obtain necessary genotypes in the embryo with accuracy equivalent to in adults. When applied to select adult siblings with known type I diabetes status, a reduction in disease incidence of 45–72% compared to random selection was achieved. ...
DOI:
10.3390/genes11060648

8. Does meal‐time insulin dosing based on fat‐protein counting give positive results in postprandial glycaemic profile after a high protein‐fat meal in adolescents with type 1 diabetes: a randomised controlled trial

Author:
Kaya, N.; Kurtoğlu, S.; Gökmen Özel, H.
Source:
Journal of human nutrition and dietetics 2020 v.33 no.3 pp. 396-403
ISSN:
0952-3871
Subject:
insulin-dependent diabetes mellitus,   etc   ; adolescents; blood glucose; glucose; insulin; insulin replacement therapy; patients; randomized clinical trials; test meals;     Show all 9 Subjects
Abstract:
... BACKGROUND: The present study investigated the effects of fat‐protein (CFP) counting in addition to carbohydrate (CARB) counting for calculating prandial insulin dosage on blood glucose profile in patients with type 1 diabetes (T1D) on basal‐bolus insulin therapy. METHODS: In this single centre, cross‐over, randomised, controlled study, control meal (SM: standard meal using a carbohydrate counting ...
DOI:
10.1111/jhn.12711

9. Association between change in self-reported sugar intake and a sugar biomarker (δ¹³C) in children at increased risk for type 1 diabetes

Author:
Henze, Martha M.; Bemis, Elizabeth A.; Seifert, Jennifer A.; Johnson, Randi K.; Dong, Fran; Rewers, Marian; Norris, Jill M.
ISSN:
2048-6790
Subject:
insulin-dependent diabetes mellitus,   etc   ; added sugars; biomarkers; carbon; children; compliance; dietary carbohydrate; erythrocytes; nitrogen; risk; stable isotopes; Colorado;     Show all 12 Subjects
Abstract:
... We examined whether change in added sugar intake is associated with change in δ¹³C, a novel sugar biomarker, in thirty-nine children aged 5–10 years selected from a Colorado (USA) prospective cohort of children at increased risk for type 1 diabetes. Reported added sugar intake via FFQ and δ¹³C in erythrocytes were measured at two time points a median of 2 years apart. Change in added sugar intake ...
DOI:
10.1017/jns.2020.9

10. Micronutrients in autoimmune diseases: possible therapeutic benefits of zinc and vitamin D

Author:
Wessels, Inga; Rink, Lothar
Source:
The Journal of nutritional biochemistry 2020 v.77 pp. 108240
ISSN:
0955-2863
Subject:
insulin-dependent diabetes mellitus,   etc   ; Crohn disease; cost effectiveness; immune response; immune system; pathogens; rheumatoid arthritis; sclerosis; therapeutics; vitamin D; zinc;     Show all 11 Subjects
Abstract:
... A functional immune system is essential for healthy life. This is achieved by the coordinate activation and interaction of different immune cells. One should be aware that activation of the immune response is as important as its deactivation when the pathogens are cleared, as otherwise host tissue can be damaged up to life-threatening levels.Autoimmune diseases (AID) represent a phenomenon of immu ...
DOI:
10.1016/j.jnutbio.2019.108240

11. Letter to the Editor Re: Scott S.N., et al. Nutrients 2019, 11(5), 1022

Author:
Kushner, Jake A.
Source:
Nutrients 2019 v.11 no.11
ISSN:
2072-6643
Subject:
insulin-dependent diabetes mellitus,   etc   ; athletic performance; carbohydrates; nutrients;     Show all 4 Subjects
Abstract:
... I read with great interest the thoughtful review concerning the potential impact of carbohydrate restriction in type 1 diabetes on glycaemic parameters and athletic performance [...] ...
DOI:
10.3390/nu11112700
PubMed:
31703469
PubMed Central:
PMC6893803

12. Role of regulatory T cells in Schistosoma-mediated protection against type 1 diabetes

Author:
Tang, Chun-lian; Gao, Yan-ru; Wang, Li-xia; Zhu, Ya-wen; Pan, Qun; Zhang, Rong-hui; Xiong, Ying
Source:
Molecular and cellular endocrinology 2019 v.491 pp. 110434
ISSN:
0303-7207
Subject:
insulin-dependent diabetes mellitus,   etc   ; Schistosoma; T-lymphocytes; hygiene; parasites; pathogens;     Show all 6 Subjects
Abstract:
... The prevalence of T1D in developed societies is partly based on the hygiene hypothesis, that is, the loss of exposure to infectious agents accompanies the loss of immune stimuli shaping the immune system during development. Indeed, the components of parasites, such as Schistosoma, have been reported to ameliorate or prevent the development of T1D, which might be associated with immune cell activit ...
DOI:
10.1016/j.mce.2019.04.014

13. Vitamin D Pathway Genetic Variation and Type 1 Diabetes: A Case–Control Association Study

Author:
Almeida, Joana T.; Rodrigues, Dircea; Guimarães, Joana; Lemos, Manuel C.
Source:
Genes 2020 v.11 no.8
ISSN:
2073-4425
Subject:
insulin-dependent diabetes mellitus,   etc   ; alleles; biochemical pathways; blood serum; confidence interval; disease susceptibility; gene frequency; genetic variation; genotype; hydroxylation; loci; odds ratio; patients; single nucleotide polymorphism; vitamin D;     Show all 15 Subjects
Abstract:
... Vitamin D has immunomodulatory effects, and its deficiency has been implicated in the autoimmune process of type 1 diabetes. Serum vitamin D levels are influenced by variants in genes involved in the synthesis, transport, hydroxylation and degradation of vitamin D. The aim of this study was to assess if single nucleotide polymorphisms (SNPs) at the DHCR7 (rs12785878), GC (rs2282679), CYP2R1 (rs206 ...
DOI:
10.3390/genes11080897

14. Alginate@TiO2 hybrid microcapsules as a reservoir of beta INS-1E cells with controlled insulin delivery

Author:
Leroux, Grégory; Neumann, Myriam; Meunier, Christophe F.; Michiels, Carine; Wang, Li; Su, Bao-Lian
Source:
Journal of materials science 2020 v.55 no.18 pp. 7857-7869
ISSN:
0022-2461
Subject:
insulin-dependent diabetes mellitus,   etc   ; alginates; biochemical pathways; biocompatible materials; encapsulation; immunosuppression; insulin; insulin secretion; islets of Langerhans; nutrients; rats; therapeutics; titanium dioxide;     Show all 13 Subjects
Abstract:
... Designing biocompatible materials to encapsulate xenogeneic insulin-releasing β-cells for transplantation has been considered as a promising alternative to avoid the immunosuppression and drawbacks of the treatment of Type 1 diabetes mellitus (T1D) by direct islet transplantation. The current work for the first time studied a hybrid alginate@TiO₂ microcapsule as a reservoir for rat insulinoma-deri ...
DOI:
10.1007/s10853-020-04576-9

15. Ambient air pollution and incidence of early-onset paediatric type 1 diabetes: A retrospective population-based cohort study

Author:
Elten, Michael; Donelle, Jessy; Lima, Isac; Burnett, Richard T.; Weichenthal, Scott; Stieb, David M.; Hystad, Perry; van Donkelaar, Aaron; Chen, Hong; Paul, Lauren A.; Crighton, Eric; Martin, Randall V.; Decou, Mary Lou; Luo, Wei; Lavigne, Éric
Source:
Environmental research 2020 v.184 pp. 109291
ISSN:
0013-9351
Subject:
insulin-dependent diabetes mellitus,   etc   ; air pollutants; air pollution; calcium; childhood; children; cohort studies; nitrogen dioxide; oxidants; ozone; particulates; pregnancy; regression analysis; Ontario;     Show all 14 Subjects
Abstract:
... Studies have reported increasing incidence rates of paediatric diabetes, especially among those aged 0–5 years. Epidemiological evidence linking ambient air pollution to paediatric diabetes remains mixed.This study investigated the association between maternal and early-life exposures to common air pollutants (NO₂, PM₂.₅, O₃, and oxidant capacity [Ox; the redox-weighted average of O₃ and NO₂]) and ...
DOI:
10.1016/j.envres.2020.109291

16. Modified apple polysaccharide capped gold nanoparticles for oral delivery of insulin

Author:
Kumari, Yogita; Singh, Sachin Kumar; Kumar, Rajesh; Kumar, Bimlesh; Kaur, Gurmandeep; Gulati, Monica; Tewari, Devesh; Gowthamarajan, K.; Karri, V.V.S. Narayana Reddy; Ayinkamiye, Clarisse; Khursheed, Rubiya; Awasthi, Ankit; Pandey, Narendra Kumar; Mohanta, Souvik; Gupta, Saurabh; Corrie, Leander; Patni, Pooja; Kumar, Rajan; Kumar, Rakesh
Source:
International journal of biological macromolecules 2020 v.149 pp. 976-988
ISSN:
0141-8130
Subject:
insulin-dependent diabetes mellitus,   etc   ; animal models; apples; blood glucose; body weight; creatinine; insulin; lipid composition; liver; nanogold; oral administration; polysaccharides; streptozotocin; urea; zeta potential;     Show all 15 Subjects
Abstract:
... The study entailed formulation of gold nanoparticles (AuNPs) upon reduction of chloroauric acid by modified apple polysaccharide (MAP). AuNPs were conjugated with insulin (INS) for its oral delivery to treat type 1 diabetes mellitus (DM). The size of MAP conjugated AuNPs loaded with INS was 124 ± 8.55 nm with zeta potential −10.5 ± 0.54 mV. The animal study carried out in streptozotocin induced ra ...
DOI:
10.1016/j.ijbiomac.2020.01.302

17. Investigation of endoplasmic reticulum stress and sonic hedgehog pathway in diabetic liver injury in mice

Author:
Sahinturk, Varol; Kacar, Sedat; Sahin, Erhan; Aykanat, Nuriye Ezgi Bektur
Source:
Life sciences 2020 v.246 pp. 117416
ISSN:
0024-3205
Subject:
insulin-dependent diabetes mellitus,   etc   ; Western blotting; alanine transaminase; aspartate transaminase; blood glucose; blood sampling; blood serum; endoplasmic reticulum; endoplasmic reticulum stress; histopathology; liver; liver regeneration; males; proteins;     Show all 14 Subjects
Abstract:
... Diabetes is a common metabolic disease which damages many organs including the liver and causes endoplasmic reticulum (ER) stress, which originates from non-folded proteins. Sonic hedgehog (Shh) pathway plays a role in liver regeneration and repair. To our knowledge, there is no study showing the relation between ER stress and Shh pathway in the liver in diabetes. Thus, the aim of this study was t ...
DOI:
10.1016/j.lfs.2020.117416

18. Cell-mimic polymersome-shielded islets for long-term immune protection of neonatal porcine islet-like cell clusters

Author:
Kim, Hyun-Ouk; Lee, Sang Hoon; Na, Woonsung; Lim, Jong-Woo; Park, Geunseon; Park, Chaewon; Lee, Hwunjae; Kang, Aram; Haam, Seungjoo; Choi, Inho; Kang, Jung-Taek; Song, Daesub
Source:
Journal of materials chemistry B 2020 v.8 no.12 pp. 2476-2482
ISSN:
2050-7518
Subject:
insulin-dependent diabetes mellitus,   etc   ; autoimmunity; binding capacity; cell membranes; cell transplantation; coatings; electrostatic interactions; encapsulation; engineering; hydrogen bonding; immunosuppression; insulin secretion; nanocapsules; permeability; polyethylene glycol; swine;     Show all 16 Subjects
Abstract:
... Although islet cell transplantation has emerged as a promising treatment for type 1 diabetes, it remains an unmet clinical application due to the need for immunosuppression to prevent islet elimination and autoimmunity. To solve these problems, we developed novel nanoencapsulation of neonatal porcine islet-like cell clusters (NPCCs) with cell-mimic polymersomes (PSomes) based on PEG-b-PLA (poly(et ...
DOI:
10.1039/c9tb02270h

19. Silica microsphere–resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats

Author:
Kalirajan, Cheirmadurai; Palanisamy, Thanikaivelan
Source:
Biomaterials science 2020 v.8 no.6 pp. 1622-1637
ISSN:
2047-4849
Subject:
insulin-dependent diabetes mellitus,   etc   ; albino; angiogenesis; biocompatibility; burns (injuries); collagen; crosslinking; fenugreek; granulation tissue; immunohistochemistry; oxidation; polysaccharides; rats; silica; spectral analysis; tissue repair; transforming growth factor beta 3;     Show all 17 Subjects
Abstract:
... The existence of diabetes and microbial infection in burn wounds makes the healing process more complex. Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica–resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection. The spectroscopic analyses of the ...
DOI:
10.1039/c9bm01089k

20. Recent Insights into Beta-cell Exocytosis in Type 2 Diabetes

Author:
Thurmond, Debbie C.; Gaisano, Herbert Y.
Source:
Journal of molecular biology 2020 v.432 no.5 pp. 1310-1325
ISSN:
0022-2836
Subject:
insulin-dependent diabetes mellitus,   etc   ; SNARE proteins; adults; exocytosis; glucose; insulin; islets of Langerhans; morbidity; mortality; noninsulin-dependent diabetes mellitus; United States;     Show all 11 Subjects
Abstract:
... As one of the leading causes of morbidity and mortality worldwide, diabetes affects an estimated 422 million adults, and it is expected to continue expanding such that by 2050, 30% of the U.S. population will become diabetic within their lifetime. Out of the estimated 422 million people currently afflicted with diabetes worldwide, about 5% have type 1 diabetes (T1D), while the remaining ~95% of di ...
DOI:
10.1016/j.jmb.2019.12.012