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1. Role of regulatory T cells in Schistosoma-mediated protection against type 1 diabetes

Author:
Tang, Chun-lian; Gao, Yan-ru; Wang, Li-xia; Zhu, Ya-wen; Pan, Qun; Zhang, Rong-hui; Xiong, Ying
Source:
Molecular and cellular endocrinology 2019 v.491 pp. 110434
ISSN:
0303-7207
Subject:
insulin-dependent diabetes mellitus,   etc   ; Schistosoma; T-lymphocytes; hygiene; parasites; pathogens;     Show all 6 Subjects
Abstract:
... The prevalence of T1D in developed societies is partly based on the hygiene hypothesis, that is, the loss of exposure to infectious agents accompanies the loss of immune stimuli shaping the immune system during development. Indeed, the components of parasites, such as Schistosoma, have been reported to ameliorate or prevent the development of T1D, which might be associated with immune cell activit ...
DOI:
10.1016/j.mce.2019.04.014

2. Postprandial Glucose Control in Type 1 Diabetes: Importance of the Gastric Emptying Rate

Author:
Lupoli, Roberta; Pisano, Federica; Capaldo, Brunella
Source:
Nutrients 2019 v.11 no.7
ISSN:
2072-6643
Subject:
insulin-dependent diabetes mellitus,   etc   ; algorithms; gastric emptying; glucose; glycemic control; hyperglycemia; insulin; insulin replacement therapy; patients;     Show all 9 Subjects
Abstract:
... The achievement of optimal post-prandial (PP) glucose control in patients with type 1 diabetes (T1DM) remains a great challenge. This review summarizes the main factors contributing to PP glucose response and discusses the likely reasons why PP glucose control is rarely achieved in T1DM patients. The macronutrient composition of the meal, the rate of gastric emptying and premeal insulin administra ...
DOI:
10.3390/nu11071559

3. Experiences of Adolescents and Emerging Adults Living With Type 1 Diabetes

Author:
Datye, Karishma; Bonnet, Kemberlee; Schlundt, David; Jaser, Sarah
Source:
TheDiabetes educator 2019 v.45 no.2 pp. 194-202
ISSN:
1554-6063
Subject:
insulin-dependent diabetes mellitus,   etc   ; adolescents; disease control; focus groups; health education; patient education; patients; young adults;     Show all 8 Subjects
Abstract:
... The purpose of this study was to identify barriers to adherence in type 1 diabetes through adolescent focus groups and to use this information to determine how diabetes educators can have a positive impact on their patients’ diabetes management. Two focus groups were conducted with adolescents and young adults (n = 11) ages 17 to 21 with type 1 diabetes. A focus group script, which consisted of 4 ...
DOI:
10.1177/0145721718825342

4. Localized immune tolerance from FasL-functionalized PLG scaffolds

Author:
Skoumal, Michael; Woodward, Kyle B.; Zhao, Hong; Wang, Feng; Yolcu, Esma S.; Pearson, Ryan M.; Hughes, Kevin R.; García, Andrés J.; Shea, Lonnie D.; Shirwan, Haval
Source:
Biomaterials 2019 v.192 pp. 271-281
ISSN:
0142-9612
Subject:
insulin-dependent diabetes mellitus,   etc   ; apoptosis; biotin; blood glucose; immunosuppression; liver; porous media; rapamycin; streptavidin; therapeutics;     Show all 10 Subjects
Abstract:
... Intraportal allogeneic islet transplantation has been demonstrated as a potential therapy for type 1 diabetes (T1D). The placement of islets into the liver and chronic immunosuppression to control rejection are two major limitations of islet transplantation. We hypothesize that localized immunomodulation with a novel form of FasL chimeric with streptavidin, SA-FasL, can provide protection and long ...
DOI:
10.1016/j.biomaterials.2018.11.015

5. Targeting Type 1 Diabetes: Selective Approaches for New Therapies

Author:
Sheehy, Daniel F.; Quinnell, Sean P.; Vegas, Arturo J.
Source:
Biochemistry 2019 v.58 no.4 pp. 214-233
ISSN:
1520-4995
Subject:
insulin-dependent diabetes mellitus,   etc   ; amputation; autoimmunity; blindness; inflammation; insulin; islets of Langerhans; patients; renal failure;     Show all 9 Subjects
Abstract:
... The clinical onset of type 1 diabetes is characterized by the destruction of the insulin-producing β cells of the pancreas and is caused by autoantigen-induced inflammation (insulitis) of the islets of Langerhans. The current standard of care for type 1 diabetes mellitus patients allows for management of the disease with exogenous insulin, but patients eventually succumb to many chronic complicati ...
DOI:
10.1021/acs.biochem.8b01118

6. Detecting autoreactive B cells in the peripheral blood of people with type 1 diabetes using ELISpot

Author:
Powell, W.E.; Hanna, S.J.; Hocter, C.N.; Robinson, E.; Lewis, M.; Dunseath, G.; Luzio, S.; Howell, A.; Dayan, C.M.; Wong, F.S.
Source:
Journal of immunological methods 2019 v.471 pp. 61-65
ISSN:
0022-1759
Subject:
insulin-dependent diabetes mellitus,   etc   ; B-lymphocytes; T-lymphocytes; autoantibodies; autoantigens; blood serum; enzymes; glutamic acid; phenotype; secretion;     Show all 10 Subjects
Abstract:
... Type 1 diabetes mellitus (T1D) is an autoimmune disorder where T lymphocytes damage the islet beta cells but B lymphocytes also play an important role. Although changes in peripheral B cell phenotype have been observed, little is known about the B cells that secrete the autoantibodies.We developed a sensitive B cell enzyme-linked immunospot assay (ELISpot assay) to detect individual B cell antibod ...
DOI:
10.1016/j.jim.2019.05.007

7. Home Telemedicine (CoYoT1 Clinic): A Novel Approach to Improve Psychosocial Outcomes in Young Adults With Diabetes

Author:
Bakhach, Marwan; Reid, Mark W.; Pyatak, Elizabeth A.; Berget, Cari; Cain, Cindy; Thomas, John “Fred”; Klingensmith, Georgeanna J.; Raymond, Jennifer K.
Source:
TheDiabetes educator 2019 v.45 no.4 pp. 420-430
ISSN:
1554-6063
Subject:
insulin-dependent diabetes mellitus,   etc   ; adolescence; distress; epidemiological studies; health education; males; mental depression; models; patients; self-efficacy; telemedicine; young adults;     Show all 12 Subjects
Abstract:
... To assess the impact of a home telemedicine clinic model (CoYoT1 Clinic) on psychosocial and behavioral outcomes designed for young adults (YAs) with type 1 diabetes (T1D). YAs self-selected to participate in the CoYoT1 Clinic or serve as a usual care control. CoYoT1 Clinic visits consisted of an individual appointment with a provider and a group appointment with other YAs with T1D using home tele ...
DOI:
10.1177/0145721719858080

8. Supplementary Nitric Oxide Donors and Exercise as Potential Means to Improve Vascular Health in People with Type 1 Diabetes: Yes to NO?

Author:
McCarthy, Olivia; Moser, Othmar; Eckstein, Max L.; Bain, Stephen C.; Pitt, Jason; Bracken, Richard
Source:
Nutrients 2019 v.11 no.7
ISSN:
2072-6643
Subject:
insulin-dependent diabetes mellitus,   etc   ; arginine; citrulline; enzyme activity; exercise; metabolism; nitrates; nitric oxide; nitric oxide synthase; nitrites; risk reduction; tempering;     Show all 12 Subjects
Abstract:
... Type 1 diabetes (T1D) is associated with a greater occurrence of cardiovascular pathologies. Vascular dysfunction has been shown at the level of the endothelial layers and failure to maintain a continuous pool of circulating nitric oxide (NO) has been implicated in the progression of poor vascular health. Biochemically, NO can be produced via two distinct yet inter-related pathways that involve an ...
DOI:
10.3390/nu11071571

9. MyDiaText™: Feasibililty and Functionality of a Text Messaging System for Youth With Type 1 Diabetes

Author:
Kaushal, Tara; Montgomery, Kathleen A.; Simon, Reid; Lord, Kelly; Dougherty, Jennifer; Katz, Lorraine E. Levitt; Lipman, Terri H.
Source:
TheDiabetes educator 2019 v.45 no.3 pp. 253-259
ISSN:
1554-6063
Subject:
insulin-dependent diabetes mellitus,   etc   ; Internet; adolescents; behavior change; consumer satisfaction; females; health education; males; screening; surveys; user interface; youth;     Show all 12 Subjects
Abstract:
... The purpose of this study was to determine the feasibility and functionality of MyDiaText™, a website and text messaging platform created to support behavior change in adolescents with type 1 diabetes (T1DM) and to evaluate user satisfaction of the application. This study was a nonrandomized, prospective, pilot trial to test the feasibility and user interface with MyDiaText, a text message system ...
DOI:
10.1177/0145721719837895

10. Graphically encoded suspension array for multiplex immunoassay and quantification of autoimmune biomarkers in patient sera

Author:
Zheng, Kexiao; Chen, Chao; Chen, Xiuli; Xu, Menghong; Chen, Linqi; Hu, Yining; Bai, Yanan; Liu, Binghuan; Yan, Cheng; Wang, Hong; Li, Jiong
Source:
Biosensors & bioelectronics 2019 v.132 pp. 47-54
ISSN:
0956-5663
Subject:
insulin-dependent diabetes mellitus,   etc   ; automation; biomarkers; biosensors; blood serum; cost effectiveness; diagnostic techniques; drugs; immunoassays; patients; precision medicine; screening; silica;     Show all 13 Subjects
Abstract:
... In precision medicine, clinical decisions and pharmaceutical evaluations tends to be made upon parallel analysis of multiple protein biomarkers. Currently, the growing needs of high-throughput multiplex immunoassay is partially satisfied by spectrally encoded bead flow suspension arrays and other platforms, yet there is still room for progress in terms of encoding capacity, decoding accuracy, ease ...
DOI:
10.1016/j.bios.2019.02.030

11. Low-Carb and Ketogenic Diets in Type 1 and Type 2 Diabetes

Author:
Bolla, Andrea Mario; Caretto, Amelia; Laurenzi, Andrea; Scavini, Marina; Piemonti, Lorenzo
Source:
Nutrients 2019 v.11 no.5
ISSN:
2072-6643
Subject:
insulin-dependent diabetes mellitus,   etc   ; carbohydrates; glycemic control; intestinal microorganisms; ketogenic diet; noninsulin-dependent diabetes mellitus; nutritional intervention; obesity; pathogenesis; patients;     Show all 10 Subjects
Abstract:
... Low-carb and ketogenic diets are popular among clinicians and patients, but the appropriateness of reducing carbohydrates intake in obese patients and in patients with diabetes is still debated. Studies in the literature are indeed controversial, possibly because these diets are generally poorly defined; this, together with the intrinsic complexity of dietary interventions, makes it difficult to c ...
DOI:
10.3390/nu11050962

12. Performance Assessment and Modification of an Adaptive Model Predictive Control for Automated Insulin Delivery by a Multivariable Artificial Pancreas

Author:
Hajizadeh, Iman; Samadi, Sediqeh; Sevil, Mert; Rashid, Mudassir; Cinar, Ali
Source:
Industrial & engineering chemistry process design and development 2019 v.58 no.26 pp. 11506-11520
ISSN:
1520-5045
Subject:
insulin-dependent diabetes mellitus,   etc   ; algorithms; automation; chemistry; electronic learning; glucose; illicit drugs; insulin; models; pancreas; process design;     Show all 11 Subjects
Abstract:
... A controller-performance-assessment algorithm is developed to analyze the closed-loop behavior and modify the parameters of a control system employed in automated insulin delivery. To this end, various performance indices are defined to quantitatively evaluate the controller efficacy in real-time. The controller assessment and modification module also incorporates online learning from historical d ...
DOI:
10.1021/acs.iecr.8b06202

13. Engineered microenvironments and microdevices for modeling the pathophysiology of type 1 diabetes

Author:
Becker, Matthew W.; Simonovich, Jennifer A.; Phelps, Edward A.
Source:
Biomaterials 2019 v.198 pp. 49-62
ISSN:
0142-9612
Subject:
insulin-dependent diabetes mellitus,   etc   ; animal models; biomimetics; cell death; engineering; humans; immunosuppression; pathophysiology; researchers; therapeutics; translation (genetics);     Show all 11 Subjects
Abstract:
... The pathophysiology of type 1 diabetes is a complex process involving tightly controlled microenvironments, a number of highly specific immune cell – islet cell interactions, and the eventual breaking of immune tolerance leading to beta cell death. Modeling this process can provide researchers with powerful insights into how and when to best provide treatment, but has proven difficult to accuratel ...
DOI:
10.1016/j.biomaterials.2018.07.002

14. Maternal and Early Life Iron Intake and Risk of Childhood Type 1 Diabetes: A Danish Case-Cohort Study

Author:
Thorsen, Steffen Ullitz; Halldorsson, Thorhallur I.; Bjerregaard, Anne A.; Olsen, Sjurdur F.; Svensson, Jannet
Source:
Nutrients 2019 v.11 no.4
ISSN:
2072-6643
Subject:
insulin-dependent diabetes mellitus,   etc   ; childhood; children; droplets; iron; iron overload; nutrition risk assessment; pregnancy; primary contact; prospective studies; regression analysis;     Show all 11 Subjects
Abstract:
... Background: Iron overload has been associated with diabetes. Studies on iron exposure during pregnancy and in early life and risk of childhood type 1 diabetes (T1D) are sparse. We investigated whether iron supplementation during pregnancy and early in life were associated with risk of childhood T1D. Methods: In a case-cohort design, we identified up to 257 children with T1D (prevalence 0.37%) from ...
DOI:
10.3390/nu11040734

15. Rabbit models of human diseases for diagnostics and therapeutics development

Author:
Mage, Rose G.; Esteves, Pedro J.; Rader, Christoph
Source:
Developmental and comparative immunology 2019 v.92 pp. 99-104
ISSN:
0145-305X
Subject:
insulin-dependent diabetes mellitus,   etc   ; Oryctolagus cuniculus; animal models; clinical trials; diagnostic techniques; human diseases; monoclonal antibodies; rabbits; sclerosis; therapeutics;     Show all 10 Subjects
Abstract:
... This review presents some examples of studies using the European rabbit (Oryctolagus cuniculus) that have led to, and continue to, contribute to advancement of understanding of human diseases as well as therapeutics development. In addition, we tabulate FDA-approved rabbit polyclonal and rabbit monoclonal antibodies (mAbs) that are used for diagnostic applications, as well as an overview of some “ ...
DOI:
10.1016/j.dci.2018.10.003

16. Fine-Scale Online Evaluation of Glycemic Control Performance Based on Temporal Feature Analysis

Author:
Zhao, Hong; Zhao, Chunhui
Source:
Industrial & engineering chemistry process design and development 2019 v.58 no.11 pp. 4374-4386
ISSN:
1520-5045
Subject:
insulin-dependent diabetes mellitus,   etc   ; adults; data collection; glucose; glycemic control; monitoring; process design; qualitative analysis; quantitative analysis; temporal variation;     Show all 10 Subjects
Abstract:
... Traditional glycemic control metrics ignore the time axis of continuous glucose monitoring (CGM) data which thus cannot further elaborate control performance of glucose within the normal region. They cannot be implemented in real time either, which may lead to incomplete assessment. A fine-scale assessment method of glycemic control performance is proposed for glucose within the normal range. The ...
DOI:
10.1021/acs.iecr.8b05448

17. Long Term Risk of Developing Type 1 Diabetes after HPV Vaccination in Males and Females

Author:
Klein, Nicola P.; Goddard, Kristin; Lewis, Edwin; Ross, Pat; Gee, Julianne; DeStefano, Frank; Baxter, Roger
Source:
Vaccine 2019
ISSN:
0264-410X
Subject:
insulin-dependent diabetes mellitus,   etc   ; Papillomaviridae; algorithms; autoimmune diseases; cohort studies; confidence interval; females; males; models; people; risk; vaccination; vaccines; California;     Show all 14 Subjects
Abstract:
... Despite minimal evidence, public concerns that the human papillomavirus (HPV) vaccine can cause autoimmune diseases (AD) persist. We evaluated whether HPV vaccine is associated with a long-term increased risk of diabetes mellitus type 1 (DM1).This was a retrospective cohort study in which we identified all potential DM1 cases from Kaiser Permanente Northern California (KPNC) members who were betwe ...
DOI:
10.1016/j.vaccine.2019.02.051

18. Efficacy of lanthionine-stabilized angiotensin-(1-7) in type I and type II diabetes mouse models

Author:
Kuipers, Anneke; Moll, Gert N.; Wagner, Elizabeth; Franklin, Rick
Source:
Peptides 2019 v.112 pp. 78-84
ISSN:
0196-9781
Subject:
insulin-dependent diabetes mellitus,   etc   ; animal models; blood glucose; glucose tolerance tests; glycohemoglobin; insulin; noninsulin-dependent diabetes mellitus; peptidases; therapeutics;     Show all 9 Subjects
Abstract:
... Native angiotensin-(1–7) exerts many therapeutic effects. However, it is rapidly degraded by ACE and other peptidases. This drawback is largely eliminated for lanthionine-stabilized angiotensin-(1–7), termed cAng-(1–7), which is fully resistant to ACE and has strongly increased resistance to other peptidases. Goal of the present study was to test whether cAng-(1–7) has therapeutic activity in diab ...
DOI:
10.1016/j.peptides.2018.10.015

19. Reference Guide for Integrating Continuous Glucose Monitoring Into Clinical Practice

Author:
Kruger, Davida F.; Edelman, Steve V.; Hinnen, Deborah A.; Parkin, Christopher G.
Source:
TheDiabetes educator 2019 v.45 no.1_suppl pp. 3S-20S
ISSN:
1554-6063
Subject:
insulin-dependent diabetes mellitus,   etc   ; glucose; health care workers; health education; monitoring; noninsulin-dependent diabetes mellitus; patient care; patient education; patients;     Show all 9 Subjects
Abstract:
... Large randomized trials have demonstrated the efficacy of continuous glucose monitoring (CGM) in persons with type 1 diabetes and insulin-treated type 2 diabetes. The purpose of this article is to provide basic knowledge about CGM technology, discuss the use of CGM data in clinical practice, and direct clinicians to online resources that provide comprehensive information and tools relevant to pati ...
DOI:
10.1177/0145721718818066

20. Sleep in Caregivers of Children With Type 1 Diabetes

Author:
Feeley, Christine A.; Clougherty, Marilyn; Siminerio, Linda; Charron-Prochownik, Denise; Allende, Anna L.; Chasens, Eileen R.
Source:
TheDiabetes educator 2019 v.45 no.1 pp. 80-86
ISSN:
1554-6063
Subject:
insulin-dependent diabetes mellitus,   etc   ; anxiety; blood glucose; caregivers; children; descriptive studies; females; glucose; health education; psychological stress; questionnaires; sleep;     Show all 12 Subjects
Abstract:
... The purpose of this study was to explore caregivers’ descriptions of their experience of nighttime sleep. Caregivers (N = 22) of children 10 to 18 years of age with type 1 diabetes (T1D) were recruited for this descriptive study. Anonymous questionnaires contained demographic information and both open- and closed-ended questions that focused on caregiving as it related to sleep. Open-ended questio ...
DOI:
10.1177/0145721718812484