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1. Fibroblast deficiency of insulin-like growth factor 1 receptor type 1 (IGF1R) impairs initial steps of murine pheochromocytoma development

Author:
Martin, Ayelen; Venara, Marcela; Mathó, Cecilia; Olea, Fernanda D.; Fernández, María Celia; Pennisi, Patricia A.
Source:
Biochimie 2019 v.163 pp. 108-116
ISSN:
0300-9084
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; binding proteins; fibroblasts; fibronectins; heterozygosity; integrins; knockout mutants; mice; neoplasm cells; neoplasms; phenotype; secretion; subcutaneous injection;     Show all 14 Subjects
Abstract:
... Insulin-like growth factor 1 (IGF1) has a critical role in maintaining tumor phenotype and survival of already transformed murine pheochromocytoma (pheo) cells (MPC4/30) and it is required for the initial establishment of these tumors. However, the role of local IGF1/IGF1R system in tumor microenvironment has not been fully understood. In vivo, by subcutaneous injection of pheo cells in heterozygo ...
DOI:
10.1016/j.biochi.2019.06.004

2. Growth hormone (GH) receptor (GHR)-specific inhibition of GH-Induced signaling by soluble IGF-1 receptor (sol IGF-1R)

Author:
Zhang, Yue; Gc, Sajina; Patel, Sweta B.; Liu, Ying; Paterson, Andrew J.; Kappes, John C.; Jiang, Jing; Frank, Stuart J.
Source:
Molecular and cellular endocrinology 2019 v.492 pp. 110445
ISSN:
0303-7207
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; antagonists; breast neoplasms; cattle; humans; islets of Langerhans; mice; neoplasm cells; prostatic neoplasms; somatotropin; somatotropin receptors;     Show all 12 Subjects
Abstract:
... Human growth hormone (GH) binds and activates GH receptor (GHR) and prolactin (PRL) receptor (PRLR). LNCaP human prostate cancer cells express only GHR. A soluble fragment of IGF-1 receptor (IGF-1R) extracellular domain (sol IGF-1R) interacts with GHR and blocks GH signaling. We now explore sol IGF-1R's specificity for inhibiting GH signaling via GHR vs. PRLR and test GHR and PRLR extracellular do ...
DOI:
10.1016/j.mce.2019.05.004

3. Characterization of insulin and IGF-1 receptor binding in equine liver and lamellar tissue: implications for endocrinopathic laminitis

Author:
Nanayakkara, S.N.; Rahnama, S.; Harris, P.A.; Anderson, S.T.; de Laat, M.A.; Bailey, S.; Sillence, M.N.
Source:
Domestic animal endocrinology 2019 v.66 pp. 21-26
ISSN:
0739-7240
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; cell death; cell membranes; gene expression; hooves; horses; hyperinsulinemia; immunohistochemistry; insulin; insulin receptors; laminitis; liver; slaughterhouses;     Show all 14 Subjects
Abstract:
... Although it is well established that equine laminitis can be triggered by extreme hyperinsulinemia, the mechanism of insulin action is not known. High concentrations of insulin lead to separation of the weight-bearing apparatus from the hoof wall and are associated with an increased cycle of cell death and proliferation in the lamellae. Gene expression and immunohistochemistry studies have indicat ...
DOI:
10.1016/j.domaniend.2018.05.008

4. Arginine induces IGF-1 secretion from the endoplasmic reticulum

Author:
Tsugawa, Yoji; Handa, Hiroshi; Imai, Takeshi
Source:
Biochemical and biophysical research communications 2019 v.514 no.4 pp. 1128-1132
ISSN:
0006-291X
Subject:
insulin-like growth factor I,   etc   ; arginine; endoplasmic reticulum; hepatocytes; metabolism; mice; protein content; secretion; somatotropin;     Show all 9 Subjects
Abstract:
... Arginine is a semi-essential amino acid with multiple functions, including stimulating the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). IGF-1, which is produced by hepatocytes, plays important roles in cellular metabolism, proliferation, and growth. Previous studies showed that arginine-induced IGF-1 secretion occurs via two pathways: a GH-dependent pathway and an arg ...
DOI:
10.1016/j.bbrc.2019.05.044

5. Influence of Incubation Time and Incubation Tube on the Cytokine and Growth Factor Concentrations of Autologous Conditioned Serum in Horses

Author:
Lasarzik de Ascurra, Juliane; Ehrle, Anna; Einspanier, Ralf; Lischer, Christoph
Source:
Journal of equine veterinary science 2019 v.75 pp. 30-34
ISSN:
0737-0806
Subject:
insulin-like growth factor I,   etc   ; antagonists; blood sampling; blood serum; glass; horses; humans; interleukin-1beta; osteoarthritis;     Show all 9 Subjects
Abstract:
... Autologous conditioned serum (ACS) is commonly used for the treatment of human and equine osteoarthritis (OA). The objective of this study was to investigate the influence of incubation time and incubation tube on concentrations of interleukin-1 receptor antagonist (IL-1ra), interleukin-1 beta (IL-1β), and insulin-like growth factor-1 (IGF-1) in ACS of horses with and without OA. Blood samples of ...
DOI:
10.1016/j.jevs.2018.12.015

6. Association of circular Klotho and insulin-like growth factor 1 with cardiac hypertrophy indexes in athlete and non-athlete women following acute and chronic exercise

Author:
Rahimi, Sepideh; Khademvatani, Kamal; Zolfaghari, Mohammad Reza
Source:
Biochemical and biophysical research communications 2018 v.505 no.2 pp. 448-452
ISSN:
0006-291X
Subject:
insulin-like growth factor I,   etc   ; athletes; electrocardiography; exercise; hypertrophy; women;     Show all 6 Subjects
Abstract:
... Owing to the role of insulin-like growth factor 1 (IGF-I) in cardiac hypertrophy and the ability of Klotho in inhibiting the IGF-I action, we investigated effects of exercise on plasma Klotho and IGF-I and their association with cardiac hypertrophy. In this study, 10 non-athlete and 10 athlete women underwent a Bruce test (acute exercise) and 12-weeks water aerobics training (chronic exercise). El ...
DOI:
10.1016/j.bbrc.2018.09.138

7. Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time

Author:
Crosby, Priya; Hamnett, Ryan; Putker, Marrit; Hoyle, Nathaniel P.; Reed, Martin; Karam, Carolyn J.; Maywood, Elizabeth S.; Stangherlin, Alessandra; Chesham, Johanna E.; Hayter, Edward A.; Rosenbrier-Ribeiro, Lyn; Newham, Peter; Clevers, Hans; Bechtold, David A.; O’Neill, John S.
Source:
Cell 2019 v.177 no.4 pp. 896-909.e20
ISSN:
0092-8674
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; chronic diseases; circadian clocks; circadian rhythm; diabetes; gene expression; insulin; lighting; mice; microRNA; protein synthesis; proteins; rapamycin; work schedules;     Show all 15 Subjects
Abstract:
... In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting cues, adjusting internal ∼24 h rhythms to resonate with, and anticipate, external cycles of day and night. The mechanism underlying circadian entrainment to feeding time is critical for understanding why mistimed feeding, as occurs during shift work, disrupts circadian physiology, a state that is associated wit ...
DOI:
10.1016/j.cell.2019.02.017

8. Seasonal expression of insulin-like growth factor 1 (IGF-1), its receptor IGF-1R and klotho in testis and epididymis of the European bison (Bison bonasus, Linnaeus 1758)

Author:
Tabecka-Lonczynska, Anna; Mytych, Jennifer; Solek, Przemyslaw; Kowalewski, Mariusz P.; Koziorowski, Marek
Source:
Theriogenology 2019 v.126 pp. 199-205
ISSN:
0093-691X
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; Bison bonasus; Western blotting; bison; epididymis; extinction; gene expression; males; messenger RNA; protein content; protein synthesis; reproduction; reverse transcriptase polymerase chain reaction; solar radiation; testes; threatened species; Europe;     Show all 18 Subjects
Abstract:
... The European bisons are the largest mammals of Europe that are still in danger of extinction. The species conservation is associated with their continuous reproduction, and bisons are characterized by the well-pronounced seasonality of reproductive processes. However, the exact mechanisms regulating their reproduction still remain unknown. Our previous studies indicated the involvement of some of ...
DOI:
10.1016/j.theriogenology.2018.12.016

9. Heat stress decreased hair follicle population in rex rabbits

Author:
Sun, Haitao; Zhang, Yin; Bai, Liya; Wang, Yuding; Yang, Liping; Su, Wenzheng; Gao, Shuxia
Source:
Journal of animal physiology and animal nutrition 2019 v.103 no.2 pp. 501-508
ISSN:
0931-2439
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; alkaline phosphatase; body weight changes; bone morphogenetic proteins; feed conversion; hair follicles; heat; heat stress; hepatocyte growth factor; protein synthesis; rabbits; rapamycin; signal transduction; temperature;     Show all 15 Subjects
Abstract:
... The aim of this study was conducted to investigate the effect of heat stress on the hair follicle population and related signalling pathways in rex rabbits. Forty‐eight rabbits were randomly divided into two groups: one group in a high ambient environment (32 ± 2°C, heat stress) and the other group with normal temperature (20 ± 2°C, control). The results show that heat stress decreased the body we ...
DOI:
10.1111/jpn.13044

10. Overview of polyphenols and polyphenol-rich extracts as modulators of IGF-1, IGF-1R, and IGFBP expression in cancer diseases

Author:
Caban, Miłosz; Owczarek, Katarzyna; Chojnacka, Katarzyna; Lewandowska, Urszula
Source:
Journal of functional foods 2019 v.52 pp. 389-407
ISSN:
1756-4646
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; anti-inflammatory agents; apoptosis; bioactive properties; carcinogenesis; insulin-like growth factor binding proteins; mechanism of action; mitogen-activated protein kinase; neoplasms; polyphenols; receptors; signal transduction;     Show all 13 Subjects
Abstract:
... Plant polyphenols, including polyphenol-rich extracts, display various biological activities. They have been found to act as, among others, anti-oxidative, anti-proliferative, pro-apoptotic, anti-angiogenic and anti-inflammatory agents. These compounds can modulate the activities of some functional proteins and receptors, such as insulin-like growth factor system, including IGF, IGF-1R, and IGFBPs ...
DOI:
10.1016/j.jff.2018.11.003

11. Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating γ-glutamyl cyclotransferase expression

Author:
Takahashi, Tetsuyuki; Ichikawa, Hirona; Morimoto, Yuuki; Tsuneyama, Koichi; Hijikata, Takao
Source:
Biochemical and biophysical research communications 2019 v.516 no.2 pp. 388-396
ISSN:
0006-291X
Subject:
insulin-like growth factor I,   etc   ; cell proliferation; metabolome; mitogen-activated protein kinase; pancreatic neoplasms; phosphorylation; prostaglandins; receptors;     Show all 8 Subjects
Abstract:
... Inhibition of prostaglandin E2 signaling via EP2/EP4 prostanoid receptors suppresses Insulin-like growth factor (IGF)-1-induced proliferation of pancreatic cancer BxPC-3 cells. To better understand the mechanism of EP2/EP4 signaling for controlling cell proliferation, we performed metabolome analyses in BxPC-3 cells treated with IGF-1 alone or IGF-1 plus EP2/EP4 inhibitors. These analyses revealed ...
DOI:
10.1016/j.bbrc.2019.06.054

12. Effect of bST administration on plasma concentrations of IGF-I and follicular dynamics and ovulation during the interovulatory cycle of sheep and goats

Author:
Cox, J.F.; Navarrete, F.; Carrasco, A.; Dorado, J.; Saravia, F.
Source:
Theriogenology 2019 v.123 pp. 159-166
ISSN:
0093-691X
Subject:
insulin-like growth factor I,   etc   ; Saanen; animal ovaries; cattle; ewes; follicular development; goats; ovulation; radioimmunoassays; somatotropin; ultrasonography;     Show all 11 Subjects
Abstract:
... This study used a comparative approach to gather clinical information to assess the effect of bovine somatotropin (bST) on follicular dynamics and ovulation in sheep and goats during an interovulatory cycle. The performance of general markers of ovarian function and specific features of follicular dynamics obtained by daily ultrasonography (US) were used to assess the hypothesis that bST, associat ...
DOI:
10.1016/j.theriogenology.2018.10.003

13. IGF-1 and somatocrinin trigger islet differentiation in human amniotic membrane derived mesenchymal stem cells

Author:
Kharat, Avinash; Chandravanshi, Bhawna; Gadre, Shashikant; Patil, Vikrant; Bhonde, Ramesh; Dubhashi, Aparna
Source:
Life sciences 2019 v.216 pp. 287-294
ISSN:
0024-3205
Subject:
insulin-like growth factor I,   etc   ; c-peptide; gene expression; gene expression regulation; glucose; humans; mesenchymal stromal cells; somatoliberin; transcription factors;     Show all 9 Subjects
Abstract:
... To induce differentiation of human amniotic membrane derived mesenchymal stem cells (hAMMSCs) into insulin producing cells (IPCs) by treating with somatocrinin or growth hormone releasing hormone (GHRH) and Insulin-like growth factor-1 (IGF-1).In this investigation, we cultivated and characterized hAMMSCs and then treated with IGF-1 and somatocrinin to find out whether this combination gives bette ...
DOI:
10.1016/j.lfs.2018.11.028

14. Interrelationship between late gestational ewe factor and early life lamb factors in semi-arid tropical region

Author:
De, Kalyan; Swarnkar, C. P.; Prince, L. L. L.; Ali, S. F.
Source:
Tropical animal health and production 2019 v.51 no.1 pp. 249-255
ISSN:
0049-4747
Subject:
insulin-like growth factor I,   etc   ; birth weight; body condition; colostrum; ewes; immunoglobulin G; lambing; lambs; pregnancy; semiarid zones; somatotropin; tropics;     Show all 12 Subjects
Abstract:
... The limitation in feed availability in the semi-arid region during the lean period can result in a variation of the body condition, body weight of pregnant ewe which in turn may affect the lamb birth weight, colostrum immunoglobulin, growth hormone (GH), and insulin-like growth factor-1 (IGF-1). Therefore, the present study was initiated to assess the interrelationship between late gestational ewe ...
DOI:
10.1007/s11250-018-1653-0

15. Curcumol induces cell cycle arrest and apoptosis by inhibiting IGF‐1R/PI3K/Akt signaling pathway in human nasopharyngeal carcinoma CNE‐2 cells

Author:
Li, Xumei; Liu, Haowei; Wang, Juan; Qin, Jianli; Bai, Zhun; Chi, Bixia; Yan, Wei; Chen, Xu
Source:
Phytotherapy research 2018 v.32 no.11 pp. 2214-2225
ISSN:
0951-418X
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; agonists; antineoplastic activity; apoptosis; carcinogenesis; carcinoma; cell cycle checkpoints; colorectal neoplasms; humans; interphase; neoplasm cells; signal transduction;     Show all 13 Subjects
Abstract:
... Curcumol has been proved to possess antitumor effects in vivo and in vitro in several cancers. Previously, we have found that curcumol induced apoptosis in CNE‐2 cells, but its underlying mechanism has not yet been studied well. Recently, our team clarified that curcumol inhibited colorectal cancer cells' growth partially through insulin‐like growth factor 1 receptor (IGF‐1R) pathway. Given the ke ...
DOI:
10.1002/ptr.6158

16. Expression of Insulin-like Growth Factor Binding Protein-3 and Regulation of the Insulin-like Growth Factor-I Axis in Pig Testis

Author:
Park, Hyun-Jung; Lee, Won-Young; Chai, Seung-Yeon; Woo, Jae-Seok; Chung, Hak-Jae; Park, Jin-Ki; Song, Hyuk; Hong, Kwonho
Source:
Biotechnology and bioprocess engineering 2018 v.23 no.3 pp. 278-285
ISSN:
1226-8372
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; Sertoli cells; adult stem cells; coculture; extracellular matrix; genes; heparan sulfate; mitosis; spermatogonia; swine;     Show all 11 Subjects
Abstract:
... The stem cell niche is a complex unit comprising key components, such as the extracellular matrix and various paracrine factors, which regulate the differentiation of adult stem cells. In our previous study, we established pig spermatogonial stem cells (pSSCs) in culture and identified the expression of insulin-like growth factor binding protein-3 (IGFBP-3) in pSSCs. The present study investigated ...
DOI:
10.1007/s12257-018-0041-y

17. The phytoestrogen, diosgenin, directly stimulates ovarian cell functions in two farm animal species

Author:
Sirotkin, A.V.; Alexa, R.; Alwasel, S.; Harrath, A.H.
Source:
Domestic animal endocrinology 2019 v.69 pp. 35-41
ISSN:
0739-7240
Subject:
insulin-like growth factor I,   etc   ; apoptosis; diosgenin; estradiol; females; granulosa cells; immunocytochemistry; in vitro studies; models; plant estrogens; progesterone; rabbits; radioimmunoassays; reproduction; swine; testosterone;     Show all 16 Subjects
Abstract:
... The present in vitro study was conducted to examine the direct action of the plant steroidal sapogenin, diosgenin, on basic farm animal ovarian cell functions. As models, we used cultured porcine ovarian granulosa cells, porcine whole follicles, and rabbit ovarian fragments. The effects of diosgenin (0, 1, 10, or 100 μg/mL medium) on the markers of proliferation, cytoplasmic apoptosis, steroid (pr ...
DOI:
10.1016/j.domaniend.2019.04.002

18. Dietary restriction in sheep: Uterine functionality in ewes with different body reserves during early gestation

Author:
Fernández-Foren, A.; Sosa, C.; Abecia, J.A.; Vázquez, M.I.; Forcada, F.; Meikle, A.
Source:
Theriogenology 2019 v.135 pp. 189-197
ISSN:
0093-691X
Subject:
insulin-like growth factor I,   etc   ; Rasa Aragonesa; body condition; diet therapy; dietary restriction; energy; estrogen receptors; ewes; gene expression; insulin; leptin; malnutrition; messenger RNA; pregnancy; progesterone; uterus; viability;     Show all 17 Subjects
Abstract:
... The aim of this study was to characterize insulin, leptin and IGF-1 profiles after undernutrition in pregnant ewes with different initial body condition (iBCS) and to investigate embryo quality, uterine gene expression and presence and location of proteins during early gestation (day 5). Thirty-six Rasa Aragonesa ewes were divided into 2 groups with different BCS: BCS> 2.75 (high, H, n = 19) and B ...
DOI:
10.1016/j.theriogenology.2019.06.023

19. Associations of Calcium, Vitamin D, and Dairy Product Intakes with Colorectal Cancer Risk among Older Women: The Iowa Women’s Health Study

Author:
Um, Caroline Y.; Prizment, Anna; Hong, Ching-Ping; Lazovich, DeAnn; Bostick, Roberd M.
Source:
Nutrition and cancer 2019 v.71 no.5 pp. 739-748
ISSN:
1532-7914
Subject:
insulin-like growth factor I,   etc   ; calcium; colorectal neoplasms; confidence interval; dairy products; food frequency questionnaires; regression analysis; vitamin D; women; Iowa;     Show all 10 Subjects
Abstract:
... Calcium and, to a lesser extent, dairy products are consistently modestly inversely associated with colorectal cancer (CRC). Dairy products may contain components other than calcium and fat, such as insulin-like growth factor-1, that may affect CRC risk. In the prospective Iowa Women’s Health Study, calcium, dairy product, and vitamin D intakes were assessed using a semiquantitative food frequency ...
DOI:
10.1080/01635581.2018.1539188

20. Effects of antimicrobial peptides on growth, morphology of foregut villi and related genes mRNA expression in the common carp (Cyprinus carpio)

Author:
Dong, Xiao‐Qing; Qu, Gui‐Juan; Chen, Yu‐Ke; Wang, Gui‐Qin; Jiang, Dan
Source:
Aquaculture research 2019 v.50 no.7 pp. 1752-1761
ISSN:
1355-557X
Subject:
insulin-like growth factor I,   etc   ; Cyprinus carpio; antimicrobial peptides; carp; enzyme activity; foregut; gene expression; gene expression regulation; genes; interleukin-1beta; messenger RNA; villi;     Show all 12 Subjects
Abstract:
... A 60‐day feeding trial was conducted to examine the effects of different levels (0, 100, 200, 400 and 600 mg/kg) of antimicrobial peptides on growth, protease activity of foregut, the morphology of foregut villi and related genes mRNA expression level in the common carp (Cyprinus carpio). The results showed that the feed of antimicrobial peptides promote common carp growth, and the optimal dosage ...
DOI:
10.1111/are.14041