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You searched for: Keyword "insulin-like growth factor I" Remove constraint Keyword: "insulin-like growth factor I"
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1. Associations of circulating insulin-like growth factor-I with intake of dietary proteins and other macronutrients

Author:
Cody Z. Watling; Rebecca K. Kelly; Tammy Y.N. Tong; Carmen Piernas; Eleanor L. Watts; Sandar Tin Tin; Anika Knuppel; Julie A. Schmidt; Ruth C. Travis; Timothy J. Key; Aurora Perez-Cornago
Source:
Clinical nutrition 2021 v.40 no.7 pp. 4685-4693
ISSN:
0261-5614
Subject:
insulin-like growth factor I,   etc   ; alcohol drinking; alcohols; blood serum; cheeses; clinical nutrition; confidence interval; energy intake; milk; milk proteins; protein content; protein intake; regression analysis; risk; starch; yogurt;     Show all 16 Subjects
Abstract:
... Circulating insulin-like growth factor-I (IGF-I) is associated with the risk of several cancers. Dietary protein intake, particularly dairy protein, may increase circulating IGF-I; however, associations with different protein sources, other macronutrients, and fibre are inconclusive. To investigate the associations between intake of protein, macronutrients and their sources, fibre, and alcohol ...
DOI:
10.1016/j.clnu.2021.04.021

2. The Effects of Marine Algal Polyphenols, Phlorotannins, on Skeletal Muscle Growth in C2C12 Muscle Cells via Smad and IGF-1 Signaling Pathways

Author:
Seo-Young Kim; Ji-Hyeok Lee; Nalae Kang; Kil-Nam Kim; You-Jin Jeon
Source:
Marine drugs 2021 v.19 no.5 pp. -
ISSN:
1660-3397
Subject:
insulin-like growth factor I,   etc   ; Ecklonia; algae; athletic performance; energy metabolism; insulin-like growth factor I receptor; muscle development; muscles; myoblasts; myostatin; phlorotannins; polyphenols; skeletal muscle;     Show all 13 Subjects
Abstract:
... Skeletal muscle is an important tissue in energy metabolism and athletic performance. The use of effective synthetic supplements and drugs to promote muscle growth is limited by various side effects. Moreover, their use is prohibited by anti-doping agencies; hence, natural alternatives are needed. Therefore, we evaluated the muscle growth effect of substances that can act like synthetic supplement ...
DOI:
10.3390/md19050266

3. Ovarian insulin-like growth factor-I

Author:
M. Bijna; K. Karthiayini
Source:
Agricultural science digest 2020 v.40 no.4 pp. 440-444
ISSN:
0976-0547
Subject:
insulin-like growth factor I,   etc   ; agricultural sciences; animal fertility; autocrine signaling; gonadotropins; steroidogenesis;     Show all 6 Subjects
Abstract:
... The insulin-like growth factor-I is a pleotropic growth factor that modulates cell replication. Insulin-like growth factor-I is produced by granulosa, theca and luteal cells and have autocrine and paracrine actions. It plays a crucial role in animal fertility acting as a monitoring signal. Researches have shown that synergistically with gonadotropins it stimulates the growth, survivability ...
DOI:
10.18805/ag.D-5104

4. Characterization of single nucleotide polymorphism in IGF1 and IGF1R genes associated with growth traits in striped catfish (Pangasianodon hypophthalmus Sauvage, 1878)

Author:
Trang Thi Huyen Tran; Hoa Thi Nguyen; Binh Thi Nguyen Le; Phuc Huu Tran; Sang Van Nguyen; Oanh Thi Phuong Kim
Source:
Aquaculture 2021 v.538 pp. 736542
ISSN:
0044-8486
Subject:
insulin-like growth factor I,   etc   ; Pangasianodon hypophthalmus; aquaculture; aquaculture industry; fish; genetic variation; genotyping; haplotypes; insulin-like growth factor I receptor; introns; river deltas; single nucleotide polymorphism; Mekong River;     Show all 13 Subjects
Abstract:
... Development of molecular markers for growth trait in striped catfish (Pangasianodon hypophthalmus) is of importance to the aquaculture industry in the Mekong river delta. This study aims to analyze the genetic variation and the effects of the Insulin-like growth factor 1 (IGF1) and Insulin-like growth factor 1 receptor (IGF1R) genes on growth traits in striped catfish. We sequenced fragments of IG ...
DOI:
10.1016/j.aquaculture.2021.736542

5. Effect of walking exercise and nutritional plan on goat performance

Author:
Marcella Cândia D'Oliveira; Marcelo Vedovatto; Ibrahim Miranda Cortada Neto; Rafaela Nunes Coelho; Maria da Graça Morais; Marina de Nadai Bonin Gomes; João Alberto Negrão; Gumercindo Loriano Franco
Source:
Livestock science 2021 v.246 pp. 104450
ISSN:
1871-1413
Subject:
insulin-like growth factor I,   etc   ; body weight; compensatory growth; diet; exercise; fat thickness; gene expression; goats; insulin-like growth factor I receptor; longissimus muscle; somatotropin; subcutaneous fat; triiodothyronine; weight gain;     Show all 14 Subjects
Abstract:
... This study evaluated the effects of walking exercise and nutritional plan on metabolic variables and the growth of stabled goats. Thirty-six goats [body weight (BW) = 21 ± 0.3 kg] were allocated in individual pens, and the treatments were randomly assigned to the animals in a 2 × 2 factorial design. The treatments consisted of walking exercise (7,5 km/day) or not and two nutritional plans [90 % (0 ...
DOI:
10.1016/j.livsci.2021.104450

6. Anti-inflammatory effect of IGF-1 is mediated by IGF-1R cross talk with GPER in MPTP/MPP+-induced astrocyte activation

Author:
Liang-Jie Yuan; Mei Zhang; Su Chen; Wen-Fang Chen
Source:
Molecular and cellular endocrinology 2021 v.519 pp. 111053
ISSN:
0303-7207
Subject:
insulin-like growth factor I,   etc   ; antagonists; anti-inflammatory activity; astrocytes; endocrinology; estrogen receptors; inducible nitric oxide synthase; inflammation; insulin-like growth factor I receptor; mitogen-activated protein kinase; phosphatidylinositol 3-kinase; phosphorylation; polypeptides; prostaglandin synthase;     Show all 14 Subjects
Abstract:
... Insulin-like growth factor-1 (IGF-1) is a potent neuroprotective polypeptide that exerts neuroprotective effects via the IGF-1 receptor (IGF-1R). Our previous study reported that G protein-coupled estrogen receptor (GPER) was involved in the anti-apoptotic effect of IGF-1. The present study was designed to investigate the anti-inflammatory effect of IGF-1 in association with astrocyte activation a ...
DOI:
10.1016/j.mce.2020.111053

7. Effects of Insulin-Like Growth Factor 1 on the In Vitro Development of Mouse Embryos after Cryopreservation

Author:
E. Yu. Brusentsev; E. A. Kizilova; T. N. Igonina; S. V. Ranneva; S. Ya. Amstislavsky
Source:
Russian journal of developmental biology 2021 v.52 no.2 pp. 120-124
ISSN:
1062-3604
Subject:
insulin-like growth factor I,   etc   ; blastocyst; cryopreservation; cryoprotectants; culture media; freezers; genome; mice; propylene glycol;     Show all 9 Subjects
Abstract:
... Cryopreservation of gametes and embryos is widely used for mammalian genome resource banking. Effects of insulin-like growth factor-1 (IGF-1) on the in vitro development of cleavage stage CD1 mouse embryos after their cryopreservation were studied. The mouse embryos developed in vivo up to the 4–6-cell stage were frozen in a programmable freezer according to standard protocol with 10% propylene gl ...
DOI:
10.1134/S1062360421020028

8. Branched-chain amino acids partially recover the reduced growth of pigs fed with protein-restricted diets through both central and peripheral factors

Author:
Mohammad Habibi; Cedrick Shili; Julia Sutton; Parniyan Goodarzi; Excel Rio Maylem; Leon Spicer; Adel Pezeshki
Source:
Animal nutrition 2021 v.7 no.3 pp. 868-882
ISSN:
2405-6545
Subject:
insulin-like growth factor I,   etc   ; blood serum; body weight; feed intake; jejunum; neuropeptide Y; serotonin; t-test;     Show all 8 Subjects
Abstract:
... euthanized and tissue samples collected. The data were analyzed by univariate GLM or mixed procedure (SPSS) and the means were separated using paired Student's t-test followed by Benjamini-Hochberg correction. Relative to PC, NC had decreased FI, BW, unsupplemented plasma essential amino acids, serum insulin-like growth factor-I (IGF-I) and hypothalamic neuropeptide Y (NPY) (P < 0.01). Compared to NC, L25 ...
DOI:
10.1016/j.aninu.2021.02.002

9. Effects of GH/IGF axis on bone and cartilage

Author:
Manisha Dixit; Sher Bahadur Poudel; Shoshana Yakar
Source:
Molecular and cellular endocrinology 2021 v.519 pp. 111052
ISSN:
0303-7207
Subject:
insulin-like growth factor I,   etc   ; bone density; cartilage; extracellular matrix; gene targeting; metabolism; proteinases; skeleton; somatotropin;     Show all 9 Subjects
Abstract:
... Growth hormone (GH) and its mediator, the insulin-like growth factor-1 (IGF-1) regulate somatic growth, metabolism and many aspects of aging. As such, actions of GH/IGF have been studied in many tissues and organs over decades. GH and IGF-1 are part of the hypothalamic/pituitary somatotrophic axis that consists of many other regulatory hormones, receptors, binding proteins, and proteases. In human ...
DOI:
10.1016/j.mce.2020.111052

10. IGF-1 supplementation in semen affects mitochondrial functional and calcium status of buffalo sperm following cryopreservation

Author:
Amit Kumar; Gyan Singh; Jerome A; Pradeep Kumar; Arjun V; Renu Bala; Nisha Verma; R.K. Sharma
Source:
Animal reproduction science 2021 v.231 pp. 106783
ISSN:
0378-4320
Subject:
insulin-like growth factor I,   etc   ; buffaloes; calcium; cryopreservation; eggs; membrane potential; mitochondria; semen; sperm motility; spermatozoa;     Show all 10 Subjects
Abstract:
... This study was designed to examine the effects of seminal insulin-like growth factor-1 (IGF-1) supplementation on structural and functional properties of buffalo sperm post cryopreservation. Semen ejaculates from buffalo bulls (n = 6) were proportioned into four aliquots and diluted with egg yolk-based extender. Prior to equilibration, IGF-1 was added to extender as four treatments: group IGF0 (no ...
DOI:
10.1016/j.anireprosci.2021.106783

11. Postpartum nutrition affects the insulin-like growth factor system in dominant follicles and plasma of anestrous beef cows

Author:
I. Rubio; F.J. White; L.J. Spicer; R.P. Wettemann
Source:
Animal reproduction science 2021 v.229 pp. 106760
ISSN:
0378-4320
Subject:
insulin-like growth factor I,   etc   ; anovulation; beef; body condition; body weight; diet; follicular fluid; hay; insulin; postpartum interval; ultrasonography;     Show all 11 Subjects
Abstract:
... Effects of nutrition on insulin-like growth factor-I (IGF-I), IGF binding proteins (IGFBP), and insulin in plasma and dominant follicles were evaluated at day 72 and 56 (Exp. 1, n = 12 and Exp. 2, n = 28, respectively) postpartum in anovulatory primiparous beef cows. Cows were stratified based on body condition score at calving and randomly assigned to nutritional treatments: maintain (M ...
DOI:
10.1016/j.anireprosci.2021.106760

12. Food restriction reduces cortical bone mass and serum insulin-like growth factor-1 levels and promotes uterine atrophy in mice

Author:
Eri Ito; Yuiko Sato; Tami Kobayashi; Satoshi Nakamura; Yosuke Kaneko; Tomoya Soma; Tatsuaki Matsumoto; Atushi Kimura; Kana Miyamoto; Hideo Matsumoto; Morio Matsumoto; Masaya Nakamura; Kazuki Sato; Takeshi Miyamoto
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 165-171
ISSN:
0006-291X
Subject:
insulin-like growth factor I,   etc   ; amenorrhea; atrophy; blood serum; bone density; energy; exercise; females; osteoclasts; osteoporosis; research;     Show all 11 Subjects
Abstract:
... Low energy availability in female athletes often causes hypothalamic amenorrhea and osteoporosis, in turn promoting stress fractures. Mechanisms underlying these conditions remain unclear. Here we show that model mice subjected to food restriction (FR) or FR-plus-voluntary running exercise exhibit significantly reduced bone mineral density, cortical bone parameters and uterine weight than do contr ...
DOI:
10.1016/j.bbrc.2020.11.122

13. Diversity of insulin and IGF signaling in breast cancer: Implications for therapy

Author:
Michael W. Lero; Leslie M. Shaw
Source:
Molecular and cellular endocrinology 2021 v.527 pp. 111213
ISSN:
0303-7207
Subject:
insulin-like growth factor I receptor,   etc   ; biomarkers; breast neoplasms; insulin; insulin receptors; ligands; mammary glands; metabolism; therapeutics;     Show all 9 Subjects
Abstract:
... This review highlights the significance of the insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF-1R) signaling pathway in cancer and assesses its potential as a therapeutic target. Our emphasis is on breast cancer, but this pathway is central to the behavior of many cancers. An understanding of how IR/IGF-1R signaling contributes to the function of the normal mammary gland provi ...
DOI:
10.1016/j.mce.2021.111213

14. Effects of a Mixture of Humulus japonicus on Longitudinal Bone Growth in Hypophysectomized Rats

Author:
Ok-Kyung Kim; Jeong Moon Yun; Minhee Lee; Soo-Jeung Park; Dakyung Kim; Dong Hwan Oh; Hong-Sik Kim; Jeongmin Lee
Source:
Journal of medicinal food 2021 v.24 no.5 pp. 497-504
ISSN:
1557-7600
Subject:
insulin-like growth factor I,   etc   ; Humulus japonicus; bone mineralization; females; femur; functional foods; growth plate; males; somatotropin; tibia;     Show all 10 Subjects
Abstract:
... Previously, we reported that the administration of a mixture of Humulus japonicus (MH) increased the longitudinal bone growth rate in Sprague Dawley rats. In this study, we investigated the effects of the dietary administration of MH on longitudinal bone growth in growth hormone (GH)-deficient hypophysectomized male and female rats to determine whether the effect of MH was similar to that of GH. W ...
DOI:
10.1089/jmf.2020.4876

15. Identification of monoclonal antibodies suitable for blocking IGF-1 receptors in the horse

Author:
S. Rahnama; N. Vathsangam; R. Spence; S.T. Anderson; M.A. de Laat; S. Bailey; M.N. Sillence
Source:
Domestic animal endocrinology 2021 v.74 pp. 106510
ISSN:
0739-7240
Subject:
insulin-like growth factor I receptor,   etc   ; analgesia; flow cytometry; horses; humans; hyperinsulinemia; insulin; laminitis; liver; monoclonal antibodies; prototypes;     Show all 11 Subjects
Abstract:
... Prolonged hyperinsulinemia is thought to be the cause of equine endocrinopathic laminitis, a common and crippling disease of the foot, for which there are no pharmacologic treatments other than pain relief. It has been suggested that insulin causes its effects on the lamellae by activating IGF-1 receptors (IGF-1R), as insulin receptors (InsR) are scarce in this tissue, whereas IGF-1R are abundant ...
DOI:
10.1016/j.domaniend.2020.106510

16. Pilot study assessing the use of cabergoline for the treatment of cats with hypersomatotropism and diabetes mellitus

Author:
Christopher J Scudder; Katarina Hazuchova; Ruth Gostelow; David B Church; Yaiza Forcada; Robert C Fowkes; Stijn JM Niessen
Source:
Journal of feline medicine and surgery 2021 v.23 no.2 pp. 131-137
ISSN:
1532-2750
Subject:
insulin-like growth factor I,   etc   ; blood serum; cats; diabetes mellitus; insulin; medicine; patients; quality of life; questionnaires; surgery;     Show all 10 Subjects
Abstract:
... An affordable and effective treatment is needed to manage feline hypersomatotropism. The aim of this study was to assess whether treatment with oral cabergoline for 90 days in cats with hypersomatotropism and diabetes mellitus improved diabetic and insulin-like growth factor 1 (IGF-1) control. This was a prospective cohort non-blinded pilot study enrolling client-owned cats with spontaneously occu ...
DOI:
10.1177/1098612X20933213

17. Evaluation of hypophysectomy for treatment of hypersomatotropism in 25 cats

Author:
Kirsten L. van Bokhorst; Sara Galac; Hans S. Kooistra; Chiara Valtolina; Federico Fracassi; Dan Rosenberg; Björn P. Meij
Source:
Journal of veterinary internal medicine 2021 v.35 no.2 pp. 834-842
ISSN:
0891-6640
Subject:
insulin-like growth factor I,   etc   ; confidence interval; diabetes mellitus; hospitals; hypophysectomy; pituitary gland; remission; retrospective studies; somatotropin; veterinary medicine;     Show all 10 Subjects
Abstract:
... BACKGROUND: Successful treatment of cats with hypersomatotropism by transsphenoidal hypophysectomy is described in small numbers of cats. OBJECTIVES: To describe the endocrine profile, survival, and remission rates of hypersomatotropism and diabetes mellitus in a cohort of cats with hypersomatotropism that underwent hypophysectomy between 2008 and 2020. ANIMALS: Twenty‐five client‐owned cats with ...
DOI:
10.1111/jvim.16047

18. Effects of duration of betaine supplementation on growth performance and blood IGF-1 in light- and normal-weight weaner pigs under commercial conditions

Author:
Fan Liu; Erin M. Ford; Chris J. Brewster; David J. Henman; Robert J. Smits
Source:
Animal production science 2021 v.61 no.7 pp. 655-661
ISSN:
1836-0939
Subject:
insulin-like growth factor I,   etc   ; average daily gain; betaine; blood; choline; diet; feed intake; growth performance; industry; methionine; weanlings;     Show all 11 Subjects
Abstract:
... Context Betaine supplementation has been reported to increase insulin-like growth factor 1 (IGF-1) in pigs. Betaine is not generally added to weaner pig diets due to a lack of knowledge on the duration of supplementation and effect on targeted bodyweight class. Light-weight weaners, known for their inferior growth performance, may benefit from betaine supplementation during the early days post-wea ...
DOI:
10.1071/AN20144

19. Invitro effects of Type I interferons (IFNτ and IFNα) on bovine hepatocytes cultured with or without Kupffer cells

Author:
Kai Josef Endriß; Marie Margarete Meyerholz; Teresa Fischbach; Lutz Brimmers; Christiane Pfarrer; Christina Deborah Marth; Marion Schmicke
Source:
Reproduction, fertility, and development 2021 v.33 no.4 pp. 305-317
ISSN:
1031-3613
Subject:
insulin-like growth factor I,   etc   ; chemokines; coculture; gene expression; genes; hepatocytes; immune response; interferons; liver; metabolism; models; pregnancy; progesterone;     Show all 13 Subjects
Abstract:
... In cattle, maternal recognition of early pregnancy depends on the effects of the embryonic signal interferon (IFN)-τ. IFN-stimulated genes have been upregulated in the maternal liver during early pregnancy. In this study, primary hepatocyte cell culture models were evaluated for their suitability to test Type I IFN effects invitro. The expression of target genes (interferon-stimulated gene 15 (ISG ...
DOI:
10.1071/RD20278

20. Combined effect of citrulline and lactoserum on amino acid availability in aged rats

Author:
Prasanthi Jegatheesan; Christel Vicente; Perrine Marquet de Rouge; Nathalie Neveux; Radji Ramassamy; Salimata Magassa; Christian Aussel; Agathe Raynaud-Simon; Luc Cynober; Jean-Pascal De Bandt
Source:
Nutrition 2021 v.87-88 pp. 111196
ISSN:
0899-9007
Subject:
insulin-like growth factor I,   etc   ; anabolism; bioavailability; casein; citrulline; glucose; insulin; muscle protein; muscles; pharmacokinetics; protein synthesis; rapamycin; sarcopenia;     Show all 13 Subjects
Abstract:
... Age-associated sarcopenia is due to anabolic resistance to feeding. Muscle protein synthesis is improved by fast proteins (e.g., lactoserum), which increase peripheral amino acid (AA) bioavailability more rapidly than slow proteins (e.g., casein), and by citrulline. Citrulline, which limits splanchnic sequestration of AA, may more effectively increase peripheral AA bioavailability when combined wi ...
DOI:
10.1016/j.nut.2021.111196