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- Author:
- Rosadiuk, J.P.; Bruinjé, T.C.; Moslemipur, F.; Fischer-Tlustos, A.J.; Renaud, D.L.; Ambrose, D.J.; Steele, M.A.
- Source:
- Journal of dairy science 2021 v.104 no.1 pp. 1136-1152
- ISSN:
- 0022-0302
- Subject:
- insulin-like growth factor I, etc ; 3-hydroxybutyric acid; Holstein; average daily gain; blood; body condition; body weight; calves; dry matter intake; energy; feeding level; glucose; growth and development; heifers; insulin; metabolites; metabolizable energy; milk consumption; rumen; starch; total mixed rations; volatile fatty acids; whole milk; Show all 23 Subjects
- Abstract:
- ... The objectives of this study were to determine the effects of pre- and postweaning planes of nutrition on feed and metabolizable energy (ME) intake, growth, concentrations of glucose, insulin, insulin-like growth factor 1 (IGF-1), and β-hydroxybutyrate (BHB) in blood and rumen volatile fatty acids (VFA) from birth to 25 wk of age in Holstein heifers. Heifer calves (n = 36) were randomly assigned t ...
- DOI:
- 10.3168/jds.2020-18809
-
https://dx.doi.org/10.3168/jds.2020-18809
- Author:
- Liu, Hao; Dong, Xiaohui; Tan, Beiping; Du, Tao; Zhang, Shuang; Yang, Yuanzhi; Chi, Shuyan; Yang, Qihui; Liu, Hongyu
- Source:
- Aquaculture 2021 v.533 pp. 736166
- ISSN:
- 0044-8486
- Subject:
- insulin-like growth factor I, etc ; Sillago sihama; alanine transaminase; aspartate transaminase; body fat; dietary fat; dietary protein; enzyme activity; fatty-acid synthase; feed conversion; feed intake; genes; glutamate dehydrogenase; growth performance; high energy diet; high protein diet; juveniles; lipid content; lipids; lipoprotein lipase; liver; low protein diet; protein content; protein efficiency ratio; protein requirement; rapamycin; regression analysis; specific growth rate; water content; weight gain; whiting; Show all 31 Subjects
- Abstract:
- ... The purpose of this study was to estimate the effect of dietary protein and lipid levels on growth performance, feed utilization, body composition, liver metabolic enzymes activity and expression of insulin-like growth factor-1 (IGF-1) and target of rapamycin (TOR) of the northern whiting, Sillago sihama. A 56-day feeding trial was a completely randomized 4 × 3 factorial design and twelve diets we ...
- DOI:
- 10.1016/j.aquaculture.2020.736166
-
https://dx.doi.org/10.1016/j.aquaculture.2020.736166
- Author:
- Terry, Tiffany T.; Cheng, Tao; Mahjoub, Moe; Zong, Hui
- Source:
- Developmental biology 2020 v.465 no.2 pp. 130-143
- ISSN:
- 0012-1606
- Subject:
- insulin-like growth factor I, etc ; alleles; cerebellum; homozygosity; interphase; mice; models; phenotype; Show all 8 Subjects
- Abstract:
- ... During cerebellar development, granule cell progenitors (GCPs) proliferate exponentially for a fixed period, promoted by paracrine mitogenic factor Sonic Hedgehog (Shh) secreted from Purkinje cells (PCs). Dysregulation of Shh signaling leads to uncontrolled GCP proliferation and medulloblastoma. Serendipitously our previous work discovered insulin-like growth factor 1 (IGF1) as another key driver ...
- DOI:
- 10.1016/j.ydbio.2020.07.008
-
https://dx.doi.org/10.1016/j.ydbio.2020.07.008
- Author:
- Yao, Maojin; Ventura, P. Britten; Jiang, Ying; Rodriguez, Fausto J.; Wang, Lixin; Perry, Justin S.A.; Yang, Yibo; Wahl, Kelsey; Crittenden, Rowena B.; Bennett, Mariko L.; Qi, Lin; Gong, Cong-Cong; Li, Xiao-Nan; Barres, Ben A.; Bender, Timothy P.; Ravichandran, Kodi S.; Janes, Kevin A.; Eberhart, Charles G.; Zong, Hui
- Source:
- Cell 2020 v.180 no.3 pp. 502-520.e19
- ISSN:
- 0092-8674
- Subject:
- insulin-like growth factor I, etc ; astrocytes; brain; interleukin-4; mice; neoplasm cells; neoplasm progression; neoplasms; neurons; Show all 9 Subjects
- Abstract:
- ... The tumor microenvironment (TME) is critical for tumor progression. However, the establishment and function of the TME remain obscure because of its complex cellular composition. Using a mouse genetic system called mosaic analysis with double markers (MADMs), we delineated TME evolution at single-cell resolution in sonic hedgehog (SHH)-activated medulloblastomas that originate from unipotent granu ...
- DOI:
- 10.1016/j.cell.2019.12.024
-
http://dx.doi.org/10.1016/j.cell.2019.12.024
- Author:
- Shastri, Anuradha A.; Saleh, Anthony; Savage, Jason E.; DeAngelis, Tiziana; Camphausen, Kevin; Simone, Nicole L.
- Source:
- Nutrition & metabolism 2020 v.17 no.1 pp. 23
- ISSN:
- 1743-7075
- Subject:
- insulin-like growth factor I; insulin-like growth factor I receptor, etc ; Western blotting; breast neoplasms; colorectal neoplasms; liver; low calorie diet; metastasis; mice; microRNA; models; patients; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; Show all 15 Subjects
- Abstract:
- ... BACKGROUND: Metastatic cancer is incurable and understanding the molecular underpinnings is crucial to improving survival for our patients. The IGF-1/Akt signaling pathway is often impaired in cancer leading to its progression and metastases. Diet modification is known to alter the IGF-1/Akt pathway and affect the expression of microRNA involved in tumor initiation, growth and metastases. Liver me ...
- DOI:
- 10.1186/s12986-020-00437-z
- PubMed:
- 32211051
- PubMed Central:
- PMC7092508
-
https://dx.doi.org/10.1186/s12986-020-00437-z
- Author:
- Khoobbakht, Zeinab; Roostaei-Ali Mehr, Mohammad; Mohammadi, Mehrdad; Mohammadghasemi, Fahimeh; Sohani, Mohammad Mehdi
- Source:
- Research in veterinary science 2020 v.130 pp. 87-92
- ISSN:
- 0034-5288
- Subject:
- insulin-like growth factor I; insulin-like growth factor I receptor, etc ; Coturnix japonica; blood serum; chicks; cloaca; diet; epithelium; gene expression; gonadosomatic index; histology; males; messenger RNA; nanoparticles; puberty; testes; testicular development; testosterone; zinc; zinc methionine; zinc oxide; Show all 21 Subjects
- Abstract:
- ... Zinc plays an important role in the regulation of insulin-like growth factor-I (IGF-I). IGF system, in turn, has a key role in the development and functions of the reproductive organs. This research was performed to investigate the effects of different sources of zinc on IGF-I gene expression and testicular development in pre-pubertal male Japanese quail. A total of 512 unsexed day-old Japanese qu ...
- DOI:
- 10.1016/j.rvsc.2020.03.004
-
https://dx.doi.org/10.1016/j.rvsc.2020.03.004
- Author:
- Li, Ji; Liu, Yang; Liu, Huan‐qiu; Chen, Lei; Li, Rui‐jun
- Source:
- Molecular nutrition & food research 2020 v.64 no.7 pp. e1900535
- ISSN:
- 1613-4125
- Subject:
- insulin-like growth factor I; insulin-like growth factor I receptor, etc ; animal models; axons; carbohydrates; electrical treatment; electromyography; histology; hypersensitivity; ketogenic diet; muscles; myelin sheath; myelination; nerve regeneration; nerve tissue; patients; rats; Show all 17 Subjects
- Abstract:
- ... SCOPE: Recent findings indicate that the ketogenic diet (KD) is neuroprotective and electrical stimulation (ES) can improve functional recovery from peripheral nerve injury. However, it is not clear whether KD and ES play a synergistical role in the peripheral nerve recovery following injury. METHODS AND RESULTS: A KD consisting of a 3:1 ratio of fat to carbohydrate + protein is used and is couple ...
- DOI:
- 10.1002/mnfr.201900535
-
http://dx.doi.org/10.1002/mnfr.201900535
- Author:
- Hu, Xianjing; Zheng, Weiming; Luo, Yuanyuan; Ou, Xiaozheng; Song, Liyan; Zhang, Sirui; He, Tingsha; Guo, Zhongyi; Zhu, Jianhua; Shi, Hui; Huang, Weijuan; Yu, Rongmin
- Source:
- Nutrition and cancer 2020 v.72 no.2 pp. 260-272
- ISSN:
- 1532-7914
- Subject:
- insulin-like growth factor I; insulin-like growth factor I receptor, etc ; adenosine triphosphate; apoptosis; colon; colorectal neoplasms; fluorescent antibody technique; human cell lines; human diseases; inhibitory concentration 50; mice; mitosis; mucosa; phosphorylation; polypeptides; Show all 15 Subjects
- Abstract:
- ... Arca subcrenata Lischke, widely scattering offshore at neritic regions, is very popular on dining table due to its edible and medical functional meatball. This study aims to investigate the suppression of a polypeptide fraction from A. subcrenata (PAS) on human colorectal cancer HT-29 cells, and its underlying mechanism. The results showed that PAS inhibited the growth of HT-29 cells with an IC₅₀ ...
- DOI:
- 10.1080/01635581.2019.1625935
-
http://dx.doi.org/10.1080/01635581.2019.1625935
- Author:
- Wei, Yuliang; Liang, Mengqing; Xu, Houguo
- Source:
- Aquaculture nutrition 2020 v.26 no.1 pp. 145-155
- ISSN:
- 1353-5773
- Subject:
- insulin-like growth factor I; insulin-like growth factor I receptor, etc ; Scophthalmus maximus; amino acids; blood serum; diet; fish meal; fish protein hydrolysate; gene expression; intestines; messenger RNA; muscle protein; muscles; plant proteins; protein synthesis; transporters; turbot; Show all 17 Subjects
- Abstract:
- ... The effects of fish protein hydrolysate (FPH) on growth, peptide and amino acid (AA) transporters, postprandial free AA and related gene expression of IGF‐1/AKT pathway were evaluated in turbot (Scophthalmus maximus). Three diets were formulated to contain the same low level of fishmeal; meanwhile 0, 45 and 180 g/kg FPH were, respectively, supplemented to the FF (FPH‐free), FL (FPH‐Low) and FH (FP ...
- DOI:
- 10.1111/anu.12976
-
http://dx.doi.org/10.1111/anu.12976
- Author:
- Wen, Su‐Ying; Chen, Jia‐Yi; Chen, Chih‐Jung; Huang, Chih‐Yang; Kuo, Wei‐Wen
- Source:
- Environmental toxicology 2020 v.35 no.2 pp. 115-123
- ISSN:
- 1520-4081
- Subject:
- insulin-like growth factor I; insulin-like growth factor I receptor, etc ; anti-aging properties; antioxidant activity; beta-galactosidase; collagen; fibroblasts; flavonols; hydrogen peroxide; longevity; protective effect; signal transduction; skin (animal); Show all 13 Subjects
- Abstract:
- ... Galangin, a natural flavonol, has anti‐inflammatory and antioxidative potential. However, the cytoprotective effects of galangin against oxidative‐induced aging in human fibroblasts have not been well studied. IGF‐1 signaling pathway is associated with the control of aging and longevity in human. The goal of this study was to investigate the effects of galangin on human skin fibroblast HS68 cells ...
- DOI:
- 10.1002/tox.22847
-
http://dx.doi.org/10.1002/tox.22847
- Author:
- Yan, Huishi; Gao, Wenwei; Li, Qinghong; Li, Hongquan; Hao, Ruirong
- Source:
- Animal production science 2020 v.60 no.16 pp. 1894-1901
- ISSN:
- 1836-0939
- Subject:
- insulin-like growth factor I; insulin-like growth factor I receptor, etc ; diarrhea; dietary supplements; duodenum; epidermal growth factor receptors; gene expression; ileum; intestinal mucosa; jejunum; light microscopy; piglets; procyanidins; scanning electron microscopy; soybean meal; villi; Show all 16 Subjects
- Abstract:
- ... Context Grapeseed procyanidins (GSP) are widely recognised to have potential biological properties, and dietary supplementation with GSP could reduce diarrhoea incidence in weaned piglets. Aims This trial was conducted to investigate the effect of GSP on small intestinal mucosa morphology and small intestinal development in weaned piglets. Methods Seventy-two weaned piglets were randomly allocated ...
- DOI:
- 10.1071/AN18638
-
http://dx.doi.org/10.1071/AN18638
- Author:
- Rotwein, Peter
- Source:
- Molecular and cellular endocrinology 2020 v.507 pp. 110788
- ISSN:
- 0303-7207
- Subject:
- insulin-like growth factor I, etc ; gene expression; gene expression regulation; genes; genomics; humans; metabolism; signal transduction; somatotropin; transactivators; transcription (genetics); Show all 11 Subjects
- Abstract:
- ... Growth hormone (GH) plays a pivotal role in many physiological processes in humans, and in other mammalian and non-mammalian vertebrate species, through actions on somatic growth, tissue development and repair, and intermediary metabolism. This review will focus on mechanisms of GH actions on gene expression, primarily from the perspective of the genes that encode proteins stimulated by GH to regu ...
- DOI:
- 10.1016/j.mce.2020.110788
- PubMed:
- 32151566
- PubMed Central:
- PMC7138728
-
https://dx.doi.org/10.1016/j.mce.2020.110788
- Author:
- Xiagedeer, Bayindala; Kang, Chenping; Hou, Xiaohong; Hu, Hong; Xiao, Qianqian; Hao, Weidong
- Source:
- Toxicology 2020 v.429 pp. 152326
- ISSN:
- 0300-483X
- Subject:
- insulin-like growth factor I, etc ; chlorides; chlormequat; crops; embryo (animal); oral exposure; pregnancy; somatotropin; tandem mass spectrometry; Show all 9 Subjects
- Abstract:
- ... Chlormequat chloride, a plant growth regulator, is widely applied in agriculture because it can promote sturdier growth of the crops. In this research, we found that rat embryo growth on GD11 was inhibited in vitro at 50 μg/ml but promoted in vivo at 75 mg/kg.bw by maternal oral exposure. Therefore, the concentrations of chlormequat chloride in the sera of the pregnant rats on gestation day (GD)11 ...
- DOI:
- 10.1016/j.tox.2019.152326
-
https://dx.doi.org/10.1016/j.tox.2019.152326
- Author:
- Ruprechter, Gretel; Noro, Mirela; Meotti, Otavio; Batista, Chester; Adrien, M. de Lourdes; Barca, Joaquin; Meikle, Ana
- Source:
- Theriogenology 2020 v.141 pp. 173-179
- ISSN:
- 0093-691X
- Subject:
- insulin-like growth factor I, etc ; Holstein; adiponectin; calving; cohort studies; dairy cows; health status; insulin; leptin; pregnancy; reproductive performance; Show all 11 Subjects
- Abstract:
- ... To investigate the association of health status and parity with hormone profiles during the transition period and reproductive parameters in Holstein dairy cows, a prospective observational cohort study was carried out including only healthy primiparous (PP, n = 116) and multiparous (MP, n = 172) cows at the beginning of the study. A subset of 120 healthy and sick cows was randomly selected for in ...
- DOI:
- 10.1016/j.theriogenology.2019.09.026
-
https://dx.doi.org/10.1016/j.theriogenology.2019.09.026
- Author:
- Cohen, Alan A.; Coste, Christophe F. D.; Li, Xiang‐Yi; Bourg, Salomé; Pavard, Samuel
- Source:
- Functional ecology 2020 v.34 no.1 pp. 153-166
- ISSN:
- 0269-8463
- Subject:
- insulin-like growth factor I, etc ; evolution; life history; longevity; models; mortality; reproduction; stem cells; stress response; vertebrates; Show all 10 Subjects
- Abstract:
- ... Current thinking in life‐history theory and the biology of ageing suggests that ageing rates, and consequently life spans, evolve largely as a function of trade‐offs with reproduction. While various evolutionary constraints are generally acknowledged to exist, their potential role in determining ageing rates is rarely considered. This review integrates three types of information to assess the rela ...
- DOI:
- 10.1111/1365-2435.13444
-
http://dx.doi.org/10.1111/1365-2435.13444
- Author:
- Wang, J.S.; Hu, H.J.; Xu, Y.B.; Wang, D.C.; Jiang, L.; Li, K.X.; Wang, Y.Y.; Zhan, X.A.
- Source:
- Poultry science 2020 v.99 no.11 pp. 5587-5597
- ISSN:
- 0032-5791
- Subject:
- insulin-like growth factor I, etc ; absorption; amino acids; antibodies; body weight; breast muscle; broiler chickens; chicks; fasting; fatty acids; feed deprivation; glycogen; liver; minerals; pancreas; spleen; starvation; triacylglycerols; Show all 18 Subjects
- Abstract:
- ... The aim of the research was to evaluate the dynamic changes of early posthatch starvation on residual yolk absorption, synthesis of macronutrients (protein, lipid, and glycogen), and organ development in broiler chicks. A total of 720 1-day-old chicks (Lingnan Yellow) were randomly assigned to 3 treatments: group A (nonfasted), group B (fasting for 24 h after placement), and group C (fasting for 4 ...
- DOI:
- 10.1016/j.psj.2020.08.032
-
https://dx.doi.org/10.1016/j.psj.2020.08.032
- Author:
- Wang, Zhuo; Nan, Weixiao; Si, Huazhe; Wang, Shiyong; Zhang, Haihua; Li, Guangyu
- Source:
- Life sciences 2020 v.252 pp. 117667
- ISSN:
- 0024-3205
- Subject:
- insulin-like growth factor I, etc ; DNA; alopecia; cell cycle; cell movement; cell proliferation; cell viability; hair follicles; mink; pantothenic acid; signal transduction; vascular endothelial growth factors; Show all 12 Subjects
- Abstract:
- ... Pantothenic acid (PA) has been applied to treat alopecia, but the underlying mechanism is still unclear. Our study aims to explore the underlying mechanism of PA in regulating hair follicle (HF) growth.Mink HFs and dermal papilla (DP) cells were isolated and cultured in vitro. HFs and DP cells were treated with 0, 10, 20, 40 μg/ml PA. The effect of PA on HF growth, DP cell proliferation, cell cycl ...
- DOI:
- 10.1016/j.lfs.2020.117667
-
https://dx.doi.org/10.1016/j.lfs.2020.117667
- Author:
- Mogheiseh, Asghar; Ahmadi, Mohammad Rahim; Nazifi, Saeed; Mirzaei, Abdollah; Fallah, Eisa
- Source:
- Veterinary and Animal Science 2020 v.9 pp. 100067
- ISSN:
- 2451-943X
- Subject:
- insulin-like growth factor I, etc ; adiponectin; corpus luteum; dairy cows; endometritis; insulin; interleukin-1beta; interleukin-6; lactation number; leptin; pregnancy rate; progesterone; ultrasonography; uterus; Show all 14 Subjects
- Abstract:
- ... In this study, the fate of corpus luteum was investigated in cows affected by severe clinical endometritis. Also, concentration of IL-1β, IL-6, COX-2, adiponectin, leptin, progesterone (P4), PGFM, insulin, and IGF-1 were studied in severe clinical endometritis cows at day 30 ± 3 postpartum. Eighty-seven dairy cows affected by severe clinical endometritis were selected and their reproductive tract ...
- DOI:
- 10.1016/j.vas.2019.100067
-
https://dx.doi.org/10.1016/j.vas.2019.100067
- Author:
- Kazemi, Asma; Speakman, John R.; Soltani, Sepideh; Djafarian, Kurosh
- Source:
- Clinical nutrition 2020 v.39 no.6 pp. 1705-1716
- ISSN:
- 0261-5614
- Subject:
- insulin-like growth factor I, etc ; clinical trials; databases; dietary protein; guidelines; humans; insulin; longevity; low calorie diet; meta-analysis; observational studies; protein intake; rodents; systematic review; Show all 14 Subjects
- Abstract:
- ... Calorie restriction (CR) and reductions in protein intake in rodents result in increased lifespan and reduced levels of IGF-1. However, the changes in IGF-1 in humans in response to CR and elevated protein intake are confused. We conducted a systematic review and meta-analysis to investigate the effect of Calorie restriction (CR) or increase in protein intake on IGF-1 in humans. The systematic rev ...
- DOI:
- 10.1016/j.clnu.2019.07.030
-
https://dx.doi.org/10.1016/j.clnu.2019.07.030
- Author:
- Wang, Jing'an; Li, Dongfang; Zhao, Xin; Sun, Tong; Jin, Shengzhen; Wang, Hongquan; Xiao, Tiaoyi; Li, Yaoguo
- Source:
- Comparative biochemistry and physiology 2020 v.243-244 pp. 110429
- ISSN:
- 1096-4959
- Subject:
- insulin-like growth factor I, etc ; complementary DNA; gene expression; genes; liver; messenger RNA; molecular cloning; muscles; quantitative polymerase chain reaction; somatotropin; somatotropin receptors; Show all 11 Subjects
- Abstract:
- ... Growth hormone (ScGH) and growth hormone receptor (ScGHR) genes from the barbel chub (Squaliobarbus curriculus), in addition to their cDNAs, were cloned. The associations between their mRNA expression levels and growth-related traits were analysed, and the differences in the levels of expression of growth regulation-related genes between the largest and smallest individuals were compared. The full ...
- DOI:
- 10.1016/j.cbpb.2020.110429
-
https://dx.doi.org/10.1016/j.cbpb.2020.110429