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1. Differing planes of pre- and postweaning phase nutrition in Holstein heifers: I. Effects on feed intake, growth efficiency, and metabolic and development indicators

Author:
Rosadiuk, J.P.; Bruinjé, T.C.; Moslemipur, F.; Fischer-Tlustos, A.J.; Renaud, D.L.; Ambrose, D.J.; Steele, M.A.
Source:
Journal of dairy science 2021 v.104 no.1 pp. 1136-1152
ISSN:
0022-0302
Subject:
insulin-like growth factor I,   etc   ; 3-hydroxybutyric acid; Holstein; average daily gain; blood; body condition; body weight; calves; dry matter intake; energy; feeding level; glucose; growth and development; heifers; insulin; metabolites; metabolizable energy; milk consumption; rumen; starch; total mixed rations; volatile fatty acids; whole milk;     Show all 23 Subjects
Abstract:
... The objectives of this study were to determine the effects of pre- and postweaning planes of nutrition on feed and metabolizable energy (ME) intake, growth, concentrations of glucose, insulin, insulin-like growth factor 1 (IGF-1), and β-hydroxybutyrate (BHB) in blood and rumen volatile fatty acids (VFA) from birth to 25 wk of age in Holstein heifers. Heifer calves (n = 36) were randomly assigned t ...
DOI:
10.3168/jds.2020-18809

2. Effects of dietary protein and lipid levels on growth, body composition, enzymes activity, expression of IGF-1 and TOR of juvenile northern whiting, Sillago sihama

Author:
Liu, Hao; Dong, Xiaohui; Tan, Beiping; Du, Tao; Zhang, Shuang; Yang, Yuanzhi; Chi, Shuyan; Yang, Qihui; Liu, Hongyu
Source:
Aquaculture 2021 v.533 pp. 736166
ISSN:
0044-8486
Subject:
insulin-like growth factor I,   etc   ; Sillago sihama; alanine transaminase; aspartate transaminase; body fat; dietary fat; dietary protein; enzyme activity; fatty-acid synthase; feed conversion; feed intake; genes; glutamate dehydrogenase; growth performance; high energy diet; high protein diet; juveniles; lipid content; lipids; lipoprotein lipase; liver; low protein diet; protein content; protein efficiency ratio; protein requirement; rapamycin; regression analysis; specific growth rate; water content; weight gain; whiting;     Show all 31 Subjects
Abstract:
... The purpose of this study was to estimate the effect of dietary protein and lipid levels on growth performance, feed utilization, body composition, liver metabolic enzymes activity and expression of insulin-like growth factor-1 (IGF-1) and target of rapamycin (TOR) of the northern whiting, Sillago sihama. A 56-day feeding trial was a completely randomized 4 × 3 factorial design and twelve diets we ...
DOI:
10.1016/j.aquaculture.2020.736166

3. Mosaic Analysis with Double Markers reveals IGF1R function in granule cell progenitors during cerebellar development

Author:
Terry, Tiffany T.; Cheng, Tao; Mahjoub, Moe; Zong, Hui
Source:
Developmental biology 2020 v.465 no.2 pp. 130-143
ISSN:
0012-1606
Subject:
insulin-like growth factor I,   etc   ; alleles; cerebellum; homozygosity; interphase; mice; models; phenotype;     Show all 8 Subjects
Abstract:
... During cerebellar development, granule cell progenitors (GCPs) proliferate exponentially for a fixed period, promoted by paracrine mitogenic factor Sonic Hedgehog (Shh) secreted from Purkinje cells (PCs). Dysregulation of Shh signaling leads to uncontrolled GCP proliferation and medulloblastoma. Serendipitously our previous work discovered insulin-like growth factor 1 (IGF1) as another key driver ...
DOI:
10.1016/j.ydbio.2020.07.008

4. Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth

Author:
Yao, Maojin; Ventura, P. Britten; Jiang, Ying; Rodriguez, Fausto J.; Wang, Lixin; Perry, Justin S.A.; Yang, Yibo; Wahl, Kelsey; Crittenden, Rowena B.; Bennett, Mariko L.; Qi, Lin; Gong, Cong-Cong; Li, Xiao-Nan; Barres, Ben A.; Bender, Timothy P.; Ravichandran, Kodi S.; Janes, Kevin A.; Eberhart, Charles G.; Zong, Hui
Source:
Cell 2020 v.180 no.3 pp. 502-520.e19
ISSN:
0092-8674
Subject:
insulin-like growth factor I,   etc   ; astrocytes; brain; interleukin-4; mice; neoplasm cells; neoplasm progression; neoplasms; neurons;     Show all 9 Subjects
Abstract:
... The tumor microenvironment (TME) is critical for tumor progression. However, the establishment and function of the TME remain obscure because of its complex cellular composition. Using a mouse genetic system called mosaic analysis with double markers (MADMs), we delineated TME evolution at single-cell resolution in sonic hedgehog (SHH)-activated medulloblastomas that originate from unipotent granu ...
DOI:
10.1016/j.cell.2019.12.024

5. Dietary alterations modulate the microRNA 29/30 and IGF-1/AKT signaling axis in breast Cancer liver metastasis

Author:
Shastri, Anuradha A.; Saleh, Anthony; Savage, Jason E.; DeAngelis, Tiziana; Camphausen, Kevin; Simone, Nicole L.
Source:
Nutrition & metabolism 2020 v.17 no.1 pp. 23
ISSN:
1743-7075
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; Western blotting; breast neoplasms; colorectal neoplasms; liver; low calorie diet; metastasis; mice; microRNA; models; patients; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction;     Show all 15 Subjects
Abstract:
... BACKGROUND: Metastatic cancer is incurable and understanding the molecular underpinnings is crucial to improving survival for our patients. The IGF-1/Akt signaling pathway is often impaired in cancer leading to its progression and metastases. Diet modification is known to alter the IGF-1/Akt pathway and affect the expression of microRNA involved in tumor initiation, growth and metastases. Liver me ...
DOI:
10.1186/s12986-020-00437-z
PubMed:
32211051
PubMed Central:
PMC7092508

6. Supplementation of various zinc sources modify sexual development and testicular IGF family gene expression in pre-pubertal male Japanese quail

Author:
Khoobbakht, Zeinab; Roostaei-Ali Mehr, Mohammad; Mohammadi, Mehrdad; Mohammadghasemi, Fahimeh; Sohani, Mohammad Mehdi
Source:
Research in veterinary science 2020 v.130 pp. 87-92
ISSN:
0034-5288
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; Coturnix japonica; blood serum; chicks; cloaca; diet; epithelium; gene expression; gonadosomatic index; histology; males; messenger RNA; nanoparticles; puberty; testes; testicular development; testosterone; zinc; zinc methionine; zinc oxide;     Show all 21 Subjects
Abstract:
... Zinc plays an important role in the regulation of insulin-like growth factor-I (IGF-I). IGF system, in turn, has a key role in the development and functions of the reproductive organs. This research was performed to investigate the effects of different sources of zinc on IGF-I gene expression and testicular development in pre-pubertal male Japanese quail. A total of 512 unsexed day-old Japanese qu ...
DOI:
10.1016/j.rvsc.2020.03.004

7. Ketogenic Diet Potentiates Electrical Stimulation–Induced Peripheral Nerve Regeneration after Sciatic Nerve Crush Injury in Rats

Author:
Li, Ji; Liu, Yang; Liu, Huan‐qiu; Chen, Lei; Li, Rui‐jun
Source:
Molecular nutrition & food research 2020 v.64 no.7 pp. e1900535
ISSN:
1613-4125
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; animal models; axons; carbohydrates; electrical treatment; electromyography; histology; hypersensitivity; ketogenic diet; muscles; myelin sheath; myelination; nerve regeneration; nerve tissue; patients; rats;     Show all 17 Subjects
Abstract:
... SCOPE: Recent findings indicate that the ketogenic diet (KD) is neuroprotective and electrical stimulation (ES) can improve functional recovery from peripheral nerve injury. However, it is not clear whether KD and ES play a synergistical role in the peripheral nerve recovery following injury. METHODS AND RESULTS: A KD consisting of a 3:1 ratio of fat to carbohydrate + protein is used and is couple ...
DOI:
10.1002/mnfr.201900535

8. Arca subcrenata Polypeptides Inhibit Human Colorectal Cancer HT-29 Cells Growth via Suppression of IGF-1R/Akt/mTOR Signaling and ATP Production

Author:
Hu, Xianjing; Zheng, Weiming; Luo, Yuanyuan; Ou, Xiaozheng; Song, Liyan; Zhang, Sirui; He, Tingsha; Guo, Zhongyi; Zhu, Jianhua; Shi, Hui; Huang, Weijuan; Yu, Rongmin
Source:
Nutrition and cancer 2020 v.72 no.2 pp. 260-272
ISSN:
1532-7914
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; adenosine triphosphate; apoptosis; colon; colorectal neoplasms; fluorescent antibody technique; human cell lines; human diseases; inhibitory concentration 50; mice; mitosis; mucosa; phosphorylation; polypeptides;     Show all 15 Subjects
Abstract:
... Arca subcrenata Lischke, widely scattering offshore at neritic regions, is very popular on dining table due to its edible and medical functional meatball. This study aims to investigate the suppression of a polypeptide fraction from A. subcrenata (PAS) on human colorectal cancer HT-29 cells, and its underlying mechanism. The results showed that PAS inhibited the growth of HT-29 cells with an IC₅₀ ...
DOI:
10.1080/01635581.2019.1625935

9. Fish protein hydrolysate affected amino acid absorption and related gene expressions of IGF‐1/AKT pathways in turbot (Scophthalmus maximus)

Author:
Wei, Yuliang; Liang, Mengqing; Xu, Houguo
Source:
Aquaculture nutrition 2020 v.26 no.1 pp. 145-155
ISSN:
1353-5773
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; Scophthalmus maximus; amino acids; blood serum; diet; fish meal; fish protein hydrolysate; gene expression; intestines; messenger RNA; muscle protein; muscles; plant proteins; protein synthesis; transporters; turbot;     Show all 17 Subjects
Abstract:
... The effects of fish protein hydrolysate (FPH) on growth, peptide and amino acid (AA) transporters, postprandial free AA and related gene expression of IGF‐1/AKT pathway were evaluated in turbot (Scophthalmus maximus). Three diets were formulated to contain the same low level of fishmeal; meanwhile 0, 45 and 180 g/kg FPH were, respectively, supplemented to the FF (FPH‐free), FL (FPH‐Low) and FH (FP ...
DOI:
10.1111/anu.12976

10. Protective effects of galangin against H2O2‐induced aging via the IGF‐1 signaling pathway in human dermal fibroblasts

Author:
Wen, Su‐Ying; Chen, Jia‐Yi; Chen, Chih‐Jung; Huang, Chih‐Yang; Kuo, Wei‐Wen
Source:
Environmental toxicology 2020 v.35 no.2 pp. 115-123
ISSN:
1520-4081
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; anti-aging properties; antioxidant activity; beta-galactosidase; collagen; fibroblasts; flavonols; hydrogen peroxide; longevity; protective effect; signal transduction; skin (animal);     Show all 13 Subjects
Abstract:
... Galangin, a natural flavonol, has anti‐inflammatory and antioxidative potential. However, the cytoprotective effects of galangin against oxidative‐induced aging in human fibroblasts have not been well studied. IGF‐1 signaling pathway is associated with the control of aging and longevity in human. The goal of this study was to investigate the effects of galangin on human skin fibroblast HS68 cells ...
DOI:
10.1002/tox.22847

11. Effect of grapeseed procyanidins on small intestinal mucosa morphology and small intestinal development in weaned piglets

Author:
Yan, Huishi; Gao, Wenwei; Li, Qinghong; Li, Hongquan; Hao, Ruirong
Source:
Animal production science 2020 v.60 no.16 pp. 1894-1901
ISSN:
1836-0939
Subject:
insulin-like growth factor I; insulin-like growth factor I receptor,   etc   ; diarrhea; dietary supplements; duodenum; epidermal growth factor receptors; gene expression; ileum; intestinal mucosa; jejunum; light microscopy; piglets; procyanidins; scanning electron microscopy; soybean meal; villi;     Show all 16 Subjects
Abstract:
... Context Grapeseed procyanidins (GSP) are widely recognised to have potential biological properties, and dietary supplementation with GSP could reduce diarrhoea incidence in weaned piglets. Aims This trial was conducted to investigate the effect of GSP on small intestinal mucosa morphology and small intestinal development in weaned piglets. Methods Seventy-two weaned piglets were randomly allocated ...
DOI:
10.1071/AN18638

12. Regulation of gene expression by growth hormone

Author:
Rotwein, Peter
Source:
Molecular and cellular endocrinology 2020 v.507 pp. 110788
ISSN:
0303-7207
Subject:
insulin-like growth factor I,   etc   ; gene expression; gene expression regulation; genes; genomics; humans; metabolism; signal transduction; somatotropin; transactivators; transcription (genetics);     Show all 11 Subjects
Abstract:
... Growth hormone (GH) plays a pivotal role in many physiological processes in humans, and in other mammalian and non-mammalian vertebrate species, through actions on somatic growth, tissue development and repair, and intermediary metabolism. This review will focus on mechanisms of GH actions on gene expression, primarily from the perspective of the genes that encode proteins stimulated by GH to regu ...
DOI:
10.1016/j.mce.2020.110788
PubMed:
32151566
PubMed Central:
PMC7138728

13. Chlormequat chloride promotes rat embryonic growth and GH-IGF-1 axis

Author:
Xiagedeer, Bayindala; Kang, Chenping; Hou, Xiaohong; Hu, Hong; Xiao, Qianqian; Hao, Weidong
Source:
Toxicology 2020 v.429 pp. 152326
ISSN:
0300-483X
Subject:
insulin-like growth factor I,   etc   ; chlorides; chlormequat; crops; embryo (animal); oral exposure; pregnancy; somatotropin; tandem mass spectrometry;     Show all 9 Subjects
Abstract:
... Chlormequat chloride, a plant growth regulator, is widely applied in agriculture because it can promote sturdier growth of the crops. In this research, we found that rat embryo growth on GD11 was inhibited in vitro at 50 μg/ml but promoted in vivo at 75 mg/kg.bw by maternal oral exposure. Therefore, the concentrations of chlormequat chloride in the sera of the pregnant rats on gestation day (GD)11 ...
DOI:
10.1016/j.tox.2019.152326

14. Endocrine and reproductive parameters in sick and healthy primiparous and multiparous dairy cows

Author:
Ruprechter, Gretel; Noro, Mirela; Meotti, Otavio; Batista, Chester; Adrien, M. de Lourdes; Barca, Joaquin; Meikle, Ana
Source:
Theriogenology 2020 v.141 pp. 173-179
ISSN:
0093-691X
Subject:
insulin-like growth factor I,   etc   ; Holstein; adiponectin; calving; cohort studies; dairy cows; health status; insulin; leptin; pregnancy; reproductive performance;     Show all 11 Subjects
Abstract:
... To investigate the association of health status and parity with hormone profiles during the transition period and reproductive parameters in Holstein dairy cows, a prospective observational cohort study was carried out including only healthy primiparous (PP, n = 116) and multiparous (MP, n = 172) cows at the beginning of the study. A subset of 120 healthy and sick cows was randomly selected for in ...
DOI:
10.1016/j.theriogenology.2019.09.026

15. Are trade‐offs really the key drivers of ageing and life span?

Author:
Cohen, Alan A.; Coste, Christophe F. D.; Li, Xiang‐Yi; Bourg, Salomé; Pavard, Samuel
Source:
Functional ecology 2020 v.34 no.1 pp. 153-166
ISSN:
0269-8463
Subject:
insulin-like growth factor I,   etc   ; evolution; life history; longevity; models; mortality; reproduction; stem cells; stress response; vertebrates;     Show all 10 Subjects
Abstract:
... Current thinking in life‐history theory and the biology of ageing suggests that ageing rates, and consequently life spans, evolve largely as a function of trade‐offs with reproduction. While various evolutionary constraints are generally acknowledged to exist, their potential role in determining ageing rates is rarely considered. This review integrates three types of information to assess the rela ...
DOI:
10.1111/1365-2435.13444

16. Effects of posthatch feed deprivation on residual yolk absorption, macronutrients synthesis, and organ development in broiler chicks

Author:
Wang, J.S.; Hu, H.J.; Xu, Y.B.; Wang, D.C.; Jiang, L.; Li, K.X.; Wang, Y.Y.; Zhan, X.A.
Source:
Poultry science 2020 v.99 no.11 pp. 5587-5597
ISSN:
0032-5791
Subject:
insulin-like growth factor I,   etc   ; absorption; amino acids; antibodies; body weight; breast muscle; broiler chickens; chicks; fasting; fatty acids; feed deprivation; glycogen; liver; minerals; pancreas; spleen; starvation; triacylglycerols;     Show all 18 Subjects
Abstract:
... The aim of the research was to evaluate the dynamic changes of early posthatch starvation on residual yolk absorption, synthesis of macronutrients (protein, lipid, and glycogen), and organ development in broiler chicks. A total of 720 1-day-old chicks (Lingnan Yellow) were randomly assigned to 3 treatments: group A (nonfasted), group B (fasting for 24 h after placement), and group C (fasting for 4 ...
DOI:
10.1016/j.psj.2020.08.032

17. Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway

Author:
Wang, Zhuo; Nan, Weixiao; Si, Huazhe; Wang, Shiyong; Zhang, Haihua; Li, Guangyu
Source:
Life sciences 2020 v.252 pp. 117667
ISSN:
0024-3205
Subject:
insulin-like growth factor I,   etc   ; DNA; alopecia; cell cycle; cell movement; cell proliferation; cell viability; hair follicles; mink; pantothenic acid; signal transduction; vascular endothelial growth factors;     Show all 12 Subjects
Abstract:
... Pantothenic acid (PA) has been applied to treat alopecia, but the underlying mechanism is still unclear. Our study aims to explore the underlying mechanism of PA in regulating hair follicle (HF) growth.Mink HFs and dermal papilla (DP) cells were isolated and cultured in vitro. HFs and DP cells were treated with 0, 10, 20, 40 μg/ml PA. The effect of PA on HF growth, DP cell proliferation, cell cycl ...
DOI:
10.1016/j.lfs.2020.117667

18. Destination of corpus luteum in postpartum clinical endometritis cows and factors affecting self-recovery

Author:
Mogheiseh, Asghar; Ahmadi, Mohammad Rahim; Nazifi, Saeed; Mirzaei, Abdollah; Fallah, Eisa
Source:
Veterinary and Animal Science 2020 v.9 pp. 100067
ISSN:
2451-943X
Subject:
insulin-like growth factor I,   etc   ; adiponectin; corpus luteum; dairy cows; endometritis; insulin; interleukin-1beta; interleukin-6; lactation number; leptin; pregnancy rate; progesterone; ultrasonography; uterus;     Show all 14 Subjects
Abstract:
... In this study, the fate of corpus luteum was investigated in cows affected by severe clinical endometritis. Also, concentration of IL-1β, IL-6, COX-2, adiponectin, leptin, progesterone (P4), PGFM, insulin, and IGF-1 were studied in severe clinical endometritis cows at day 30 ± 3 postpartum. Eighty-seven dairy cows affected by severe clinical endometritis were selected and their reproductive tract ...
DOI:
10.1016/j.vas.2019.100067

19. Effect of calorie restriction or protein intake on circulating levels of insulin like growth factor I in humans: A systematic review and meta-analysis

Author:
Kazemi, Asma; Speakman, John R.; Soltani, Sepideh; Djafarian, Kurosh
Source:
Clinical nutrition 2020 v.39 no.6 pp. 1705-1716
ISSN:
0261-5614
Subject:
insulin-like growth factor I,   etc   ; clinical trials; databases; dietary protein; guidelines; humans; insulin; longevity; low calorie diet; meta-analysis; observational studies; protein intake; rodents; systematic review;     Show all 14 Subjects
Abstract:
... Calorie restriction (CR) and reductions in protein intake in rodents result in increased lifespan and reduced levels of IGF-1. However, the changes in IGF-1 in humans in response to CR and elevated protein intake are confused. We conducted a systematic review and meta-analysis to investigate the effect of Calorie restriction (CR) or increase in protein intake on IGF-1 in humans. The systematic rev ...
DOI:
10.1016/j.clnu.2019.07.030

20. GH and GHR gene cloning, expression and their associations with growth-related traits of the barbel chub (Squaliobarbus curriculus)

Author:
Wang, Jing'an; Li, Dongfang; Zhao, Xin; Sun, Tong; Jin, Shengzhen; Wang, Hongquan; Xiao, Tiaoyi; Li, Yaoguo
Source:
Comparative biochemistry and physiology 2020 v.243-244 pp. 110429
ISSN:
1096-4959
Subject:
insulin-like growth factor I,   etc   ; complementary DNA; gene expression; genes; liver; messenger RNA; molecular cloning; muscles; quantitative polymerase chain reaction; somatotropin; somatotropin receptors;     Show all 11 Subjects
Abstract:
... Growth hormone (ScGH) and growth hormone receptor (ScGHR) genes from the barbel chub (Squaliobarbus curriculus), in addition to their cDNAs, were cloned. The associations between their mRNA expression levels and growth-related traits were analysed, and the differences in the levels of expression of growth regulation-related genes between the largest and smallest individuals were compared. The full ...
DOI:
10.1016/j.cbpb.2020.110429