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1. Improved secretion of recombinant human IL-25 in HEK293 cells using a signal peptide-pro-peptide domain derived from Trypsin-1

Author:
Mullin, Michael J.; Wilkinson, Claire; Hiles, Ian; Smith, Kathrine J.
Source:
Biotechnology letters 2021 v.43 no.4 pp. 757-765
ISSN:
0141-5492
Subject:
interleukin-17,   etc   ; biotechnology; humans; secretion; signal peptide;     Show all 5 Subjects
Abstract:
... OBJECTIVE: To compare the effects of human Trypsin-1 signal peptide and pro-peptide on the expression and secretion efficiency of human Interleukin-25 from mammalian cells. RESULTS: The signal peptide and combined signal peptide-pro-peptide sequence of human Trypsin-1 improved the secretion of human IL-25 from 1.7 to 3.2 µg/ml and 1.7 to 8.2 µg/ml, respectively. Deletion analysis identified the mi ...
DOI:
10.1007/s10529-020-03072-z

2. The quest for faithful in vitro models of human dendritic cells types

Author:
Luo, Xin-Long; Dalod, Marc
Source:
Molecular immunology 2020 v.123 pp. 40-59
ISSN:
0161-5890
Subject:
interleukin-17,   etc   ; cytotoxicity; humans;     Show all 3 Subjects
Abstract:
... Dendritic cells (DCs) are mononuclear phagocytes that are specialized in the induction and functional polarization of effector lymphocytes, thus orchestrating immune defenses against infections and cancer. The population of DC encompasses distinct cell types that vary in their efficacy for complementary functions and are thus likely involved in defending the body against different threats. Plasmac ...
DOI:
10.1016/j.molimm.2020.04.018

3. Protection studies of an excretory–secretory protein HcABHD against Haemonchus contortus infection

Author:
Lu, Mingmin; Tian, Xiaowei; Zhang, Yang; Wang, Wenjuan; Tian, Ai-Ling; Aimulajiang, Kalibixiati; Liu, Lianrui; Li, Charles; Yan, Ruofeng; Xu, Lixin; Song, Xiaokai; Li, Xiangrui
Source:
Veterinary research 2021 v.52 no.1 pp. 3
ISSN:
1297-9716
Subject:
interleukin-17,   etc   ; Haemonchus contortus; antibodies; antigens; blood serum; eggs; goats; hemoglobin; immunization; subcutaneous injection; veterinary medicine;     Show all 11 Subjects
Abstract:
... Unlike the successful immunization of native H. contortus antigens that contributed to the realization of the first commercial vaccine Barbervax, not many studies revealed the encouraging protective efficacies of recombinant H. contortus antigens in laboratory trials or under field conditions. In our preliminary study, H. contortus α/β-hydrolase domain protein (HcABHD) was demonstrated to be an im ...
DOI:
10.1186/s13567-020-00871-0

4. Ruxolitinib attenuates experimental autoimmune encephalomyelitis (EAE) development as animal models of multiple sclerosis (MS)

Author:
Hosseini, Arezoo; Gharibi, Tohid; Mohammadzadeh, Adel; Ebrahimi-kalan, Abbas; Jadidi-niaragh, Farhad; Babaloo, Zohreh; Shanehbandi, Dariush; Baghbani, Elham; Baradaran, Behzad
Source:
Life sciences 2021 v.276 pp. 119395
ISSN:
0024-3205
Subject:
interleukin-17,   etc   ; encephalitis; interleukin-10; pathogenesis; quantitative polymerase chain reaction; sclerosis; therapeutics; transcription factors;     Show all 8 Subjects
Abstract:
... STAT3 signaling is critical for Th17 development that plays an important role in multiple sclerosis pathogenesis. To evaluate the anti-inflammatory and regulatory T cells effects of JAK1/2 and STAT3 inhibition, we assessed the JAK 1/2 inhibitor ruxolitinib effects on Th17 cell/Tregs balance.Ruxolitinib was administered to experimental autoimmune encephalomyelitis (EAE) mice via oral gavage, and it ...
DOI:
10.1016/j.lfs.2021.119395

5. Interleukin-17 mediates inflammatory tissue injury during orf development in goats

Author:
Tang, Xidian; Jing, Tian; Chen, Xi; Wang, Tianxing; Xie, Yanfei; Chen, Fengqiang; Wen, Ying; Chang, Jianjun; Chen, Dekun; Ma, Wentao
Source:
Veterinary microbiology 2021 v.258 pp. 109105
ISSN:
0378-1135
Subject:
interleukin-17,   etc   ; Orf virus; chemokines; epithelium; infectious diseases; inflammation; microbiology; neutrophils; pathogenesis; therapeutics;     Show all 10 Subjects
Abstract:
... Orf is an epithelial zoonotic infectious disease caused by orf virus (ORFV). Mounting studies have shown that IL-17-driven neutrophil inflammation plays a central role in inflammatory skin diseases. However, whether IL-17 plays a similar role and how does it work in the pathogenesis of orf is unclear. In this study, we found that during orf development, numerous inflammatory cells, especially neut ...
DOI:
10.1016/j.vetmic.2021.109105

6. Goat γδ T cell subpopulations defined by WC1 expression, responses to pathogens and cytokine production

Author:
Yirsaw, Alehegne W.; Gillespie, Alexandria; Britton, Emily; Doerle, Alyssa; Johnson, Lisa; Marston, Susan; Telfer, Janice; Baldwin, Cynthia L.
Source:
Developmental and comparative immunology 2021 v.118 pp. 103984
ISSN:
0145-305X
Subject:
interleukin-17,   etc   ; Leptospira; Mycobacterium avium; animal age; cattle; goats; hybrids; monoclonal antibodies; paratuberculosis; sheep;     Show all 10 Subjects
Abstract:
... The major functions of γδ T cells in mammals overlap with those of αβ T cells but differ in that γδ T cells are rapid responders and see different types of antigens. While γδ T cells have been shown to be a major population of circulating lymphocytes in artiodactyl species such as cattle, sheep, and pigs, less is known about these cells in goats, an important agricultural species. We have recently ...
DOI:
10.1016/j.dci.2020.103984

7. Lnc-OIP5-AS1 exacerbates aorta wall injury during the development of aortic dissection through upregulating TUB via sponging miR-143-3p

Author:
Wang, Peng; Wang, Zhiwei; Zhang, Min; Wu, Qi; Shi, Feng
Source:
Life sciences 2021 v.271 pp. 119199
ISSN:
0024-3205
Subject:
interleukin-17,   etc   ; aorta; apoptosis; bioluminescence assay; dissection; genes; interleukin-6; microRNA; precipitin tests; secretion;     Show all 10 Subjects
Abstract:
... Dysfunction of major cells constituting the aortic wall is the pathological basis for AD development. Determining whether non-coding RNAs can influence AD progression by regulating these cellular functions and identifying some specific non-coding RNAs is of great significance in uncovering molecular mechanisms of the development of AD.Microarray analyses and hierarchical clustering analysis were u ...
DOI:
10.1016/j.lfs.2021.119199

8. Double-negative T cells are absolutely elevated in patients with antineutrophil cytoplasmic autoantibody-associated vasculitis

Author:
Qin, Yan; Wang, Yanlin; Wu, Yanyao; Feng, Min; Zhao, Xiangcong; Gao, Chong; Guo, Hui; Luo, Jing
Source:
Molecular immunology 2021 v.132 pp. 250-259
ISSN:
0161-5890
Subject:
interleukin-17,   etc   ; autoantibodies; flow cytometry; interleukin-4; methylprednisolone; pathogenesis; phenotype; vasculitis;     Show all 8 Subjects
Abstract:
... CD3⁺CD4⁻CD8⁻ [double-negative (DN)] T cells play vital roles in the pathogenesis of autoimmune disorders. In this study, we investigated the exact level of DN T cells in patients with antineutrophil cytoplasmic autoantibody (ANCA)–associated vasculitis (AAV). Forty patients with active AAV and 19 healthy controls (HCs) were enrolled in this study. Peripheral mononuclear cells were characterised ph ...
DOI:
10.1016/j.molimm.2021.01.014

9. Haemonchus contortus hepatocellular carcinoma-associated antigen 59 with poly (lactic-co-glycolic acid): A promising nanovaccine candidate against Haemonchus contortus infection

Author:
Wang, QiangQiang; Muhammad, Tahir Aleem; Muhammad, Waqqas Hasan; Muhammad, Ali Memon; Muhammad, Haseeb; Yan, RuoFeng; Xu, LiXin; Song, XiaoKai; Li, XiangRui
Source:
Veterinary parasitology 2021 v.292 pp. 109398
ISSN:
0304-4017
Subject:
interleukin-17,   etc   ; Haemonchus contortus; adjuvants; antigens; immunization; interleukin-4; interleukin-9; recombinant proteins; veterinary parasitology;     Show all 9 Subjects
Abstract:
... Hepatocellular carcinoma-associated antigen 59 (HCA59), one of significant excretory/secretory products of Haemonchus contortus (HcESPs), is identified to have immunomodulatory eff ;ects on host cells. However, protection potential of the molecule in H. contortus remains poorly understood. In this study, H. contortus recombinant HCA59 protein amalgamated with poly (lactic-co-glycolic acid) (PLGA) n ...
DOI:
10.1016/j.vetpar.2021.109398

10. Intranasal boosting with MVA encoding secreted mycobacterial proteins Ag85A and ESAT-6 generates strong pulmonary immune responses and protection against M. tuberculosis in mice given BCG as neonates

Author:
Khanna, Mayank; Rady, Hamada; Dai, Guixiang; Ramsay, Alistair J.
Source:
Vaccine 2021 v.39 no.12 pp. 1780-1787
ISSN:
0264-410X
Subject:
interleukin-17,   etc   ; Mycobacterium tuberculosis; aerosols; antibodies; immunization; immunogenicity; interleukin-2; lungs; mucosa; tuberculosis; vaccines; young adults;     Show all 12 Subjects
Abstract:
... Bacille-Calmette-Guerin (BCG) has variable efficacy as an adult tuberculosis (TB) vaccine but can reduce the incidence and severity of TB infection in humans. We have engineered modified vaccinia Ankara (MVA) strain vaccine constructs to express the secreted mycobacterial proteins Ag85A and ESAT-6 (MVA-AE) and evaluated their immunogenicity and protective efficacy as mucosal booster vaccines for B ...
DOI:
10.1016/j.vaccine.2021.01.071

11. Exosomes expressing neuronal autoantigens induced immune response in antibody-positive autoimmune encephalitis

Author:
Gu, Jiachen; Jin, Tao; Li, Zongshan; Chen, Huimin; Xia, Hongbo; Xu, Xiaomin; Gui, Yaxing
Source:
Molecular immunology 2021 v.131 pp. 164-170
ISSN:
0161-5890
Subject:
interleukin-17,   etc   ; Western blotting; antibodies; autoantigens; cerebrospinal fluid; encephalitis; exosomes; immune response; immunization; neurons; pathogenesis; splenocytes;     Show all 12 Subjects
Abstract:
... The immunological role of exosomes in autoimmune encephalitis (AE) remains uncharacterized and not examined. In this study we ought to determine whether exosomes are generated in AE and to define the presence of cell surface neuronal autoantigens (autoAgs) in the cargo. Exosomes were isolated from cerebrospinal fluid (CSF) from 12 patients with anti-N-methyl-d-aspartate (NMDA) receptor encephaliti ...
DOI:
10.1016/j.molimm.2020.12.034

12. Polymorphisms and haplotypes in the Interleukin 17 Alfa gene: potential effect of smoking habits in the association with periodontitis and type 2 diabetes mellitus

Author:
Rimachi Hidalgo, Marco A.; Cirelli, Thamiris; da Silva, Bárbara Roque; Nicchio, Ingra Gagno; Nepomuceno, Rafael; Orrico, Silvana R. P.; Cirelli, Joni A.; Theodoro, Letícia Helena; Barros, Silvana P.; Scarel-Caminaga, Raquel M.
Source:
Molecular biology reports 2021 v.48 no.2 pp. 1103-1114
ISSN:
0301-4851
Subject:
interleukin-17,   etc   ; DNA; genes; haplotypes; lipid composition; lipids; molecular biology; noninsulin-dependent diabetes mellitus; periodontitis; risk;     Show all 10 Subjects
Abstract:
... Few studies evaluate interrelationships between periodontitis (P) and Type 2 Diabetes Mellitus (T2DM). The aim of this study is to investigate the genetic susceptibility to periodontitis alone, or concomitant with T2DM (as comorbidities), analyzing single nucleotide polymorphisms (SNPs) in the Interleukin 17 alpha (IL17A) gene, considering the biochemical profile and smoking habits on the subjects ...
DOI:
10.1007/s11033-021-06172-9

13. WITHDRAWN: OIP5-AS1 facilitates Th17 differentiation and EAE severity by targeting miR-140-5p to regulate RhoA/ROCK2 signaling pathway

Author:
Liu, Ruihua; Li, Yan; Zhou, Haitao; Wang, Hao; Liu, Dequan; Wang, Huilin; Wang, Zhenghua
Source:
Life sciences 2021 pp. 119108
ISSN:
0024-3205
Subject:
interleukin-17,   etc   ; Western blotting; encephalitis; etiology; flow cytometry; histology; luciferase; sclerosis; secretion;     Show all 9 Subjects
Abstract:
... This article has been withdrawn at the request of the author(s) and/or editor.The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal ...
DOI:
10.1016/j.lfs.2021.119108

14. Pregnant Women Infected with Zika Virus Show Higher Viral Load and Immunoregulatory Cytokines Profile with CXCL10 Increase

Author:
Camacho-Zavala, Elizabeth; Santacruz-Tinoco, Clara; Muñoz, Esteban; Chacón-Salinas, Rommel; Salazar-Sanchez, Ma Isabel; Grajales, Concepción; González-Ibarra, Joaquin; Borja-Aburto, Victor Hugo; Jaenisch, Thomas; Gonzalez-Bonilla, Cesar R.
Source:
Viruses 2021 v.13 no.1
ISSN:
1999-4915
Subject:
interleukin-17,   etc   ; Zika virus; blood serum; fetus; immunomodulation; interleukin-6; monitoring; pregnancy; viral load; viruses;     Show all 10 Subjects
Abstract:
... Background: Zika virus (ZIKV) infection during pregnancy usually shows only mild symptoms and is frequently subclinical. However, it can be vertically transmitted to the fetus, causing microcephaly and other congenital defects. During pregnancy, the immune environment modifications can alter the response to viruses in general and ZIKV in particular. Objective: To describe the role of pregnancy in ...
DOI:
10.3390/v13010080

15. Leukotriene B4 receptors play critical roles in house dust mites-induced neutrophilic airway inflammation and IL-17 production

Author:
Kwak, Dong-Wook; Park, Donghwan; Kim, Jae-Hong
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 646-652
ISSN:
0006-291X
Subject:
interleukin-17,   etc   ; ; asthma; chemoattractants; dust; dust mites; inflammation; ligands; mice; neutrophils; research;     Show all 11 Subjects
Abstract:
... Increased levels of neutrophils in bronchoalveolar lavage fluid (BALF) were associated with asthma severity. As leukotriene B4 (LTB₄) is a principal chemoattractant molecule for neutrophils, its receptors, BLT1 and BLT2, may contribute to neutrophil-dominant airway inflammation. In the present study, we established a mouse model of steroid-resistant, neutrophil-dominant airway inflammation by hous ...
DOI:
10.1016/j.bbrc.2020.11.027

16. Combustion-derived particulate organic matter associated with hemodynamic abnormality and metabolic dysfunction in healthy adults

Author:
Xu, Hongbing; Zhu, Yutong; Li, Lijuan; Liu, Shengcong; Song, Xiaoming; Yi, Tieci; Wang, Yang; Wang, Tong; Zhao, Qian; Liu, Lingyan; Wu, Rongshan; Liu, Shuo; Feng, Baihuan; Chen, Jie; Zheng, Lemin; Rajagopaplan, Sanjay; Brook, Robert D.; Li, Jianping; Cao, Junji; Huang, Wei
Source:
Journal of hazardous materials 2021 v.418 pp. 126261
ISSN:
0304-3894
Subject:
interleukin-17,   etc   ; alkanes; biomarkers; calcification; coal; combustion; diastolic blood pressure; inflammation; insulin; insulin resistance; particulate organic matter; traffic; China;     Show all 13 Subjects
Abstract:
... Epidemiological evidence on cardiometabolic health of particulate organic matter (POM) and its sources is sparse. In a panel of 73 healthy adults in Beijing, China, daily concentrations of ambient fine particulate matter-bound polycyclic aromatic hydrocarbons (PAHs) and n-alkanes were measured throughout the study period, and Positive Matrix Factorization approach was used to identity PAHs sources ...
DOI:
10.1016/j.jhazmat.2021.126261

17. Genome-wide identification of interleukin-17 (IL-17) / interleukin-17 receptor (IL- 17R) in turbot (Scophthalmus maximus) and expression pattern analysis after Vibrio anguillarum infection

Author:
Xue, Ting; Liu, Yiping; Cao, Min; Zhang, Xiaoyan; Fu, Qiang; Yang, Ning; Li, Chao
Source:
Developmental and comparative immunology 2021 v.121 pp. 104070
ISSN:
0145-305X
Subject:
interleukin-17,   etc   ; ; Scophthalmus maximus; Vibrio anguillarum; innate immunity; mucosal immunity; pathogens; phylogeny; protein structure; tissue distribution; turbot;     Show all 11 Subjects
Abstract:
... Interleukin-17 (IL-17) is a cytokine secreted by a variety of immune cells that plays an important role in host defense against pathogens. IL-17 usually activates downstream immune signaling pathway by binding to heterodimeric or homodimeric complex formed by IL-17 receptors (IL-17R). Describing the characteristics, tissue distribution of IL-17 and IL-17 receptor family members and their expressio ...
DOI:
10.1016/j.dci.2021.104070

18. Association of microRNA expression with changes in immune markers in workers with cadmium exposure

Author:
Goyal, Taru; Mitra, Prasenjit; Singh, Preeti; Ghosh, Raghumoy; Sharma, Shailja; Sharma, Praveen
Source:
Chemosphere 2021 v.274 pp. 129615
ISSN:
0045-6535
Subject:
interleukin-17,   etc   ; atomic absorption spectrometry; blood serum; cadmium; carcinogenesis; epigenetics; flow cytometry; handicrafts; humans; inflammation; microRNA; regression analysis; toxicity;     Show all 13 Subjects
Abstract:
... Human exposure to cadmium (Cd) is known to produce severe health effects. Recently, molecular mechanism of Cd toxicity has revealed the role of Cd in causing epigenetic alterations. miRNAs are small, non-coding RNAs which are involved in translational repression of genes. Therefore, the aim of the present study was to evaluate the alterations in expression of miRNAs associated with inflammation, c ...
DOI:
10.1016/j.chemosphere.2021.129615

19. Transforming growth factor β as a possible independent factor in chronic hepatitis B

Author:
Li, Ming-hui; Lu, Yao; Sun, Fang-fang; Chen, Qi-qi; Zhang, Lu; Lu, Hui-hui; Zeng, Zhan; Yi, Wei; Xie, Yao
Source:
Archives of virology 2021 v.166 no.7 pp. 1853-1858
ISSN:
0304-8608
Subject:
interleukin-17,   etc   ; DNA; Hepatitis B virus; alanine transaminase; chronic hepatitis B; interferon-gamma; interleukin-10; ligands; regression analysis; tyrosine; virology;     Show all 11 Subjects
Abstract:
... To investigate the association between immune-cell-related cytokines and the development of chronic hepatitis B (CHB), patients with chronic hepatitis B virus (HBV) infection in the immunotolerant (IT) phase (n = 30) or hepatitis B envelope antigen (HBeAg)-positive CHB (n = 250) were enrolled in this study. Serological indicators and plasma cytokine levels were measured at the time of enrollment. ...
DOI:
10.1007/s00705-021-05062-6

20. Analysis of miRNA expression changes in bovine endometrial stromal cells treated with lipopolysaccharide

Author:
Yan, Chenbo; Lv, Haimiao; Peng, Zhan; Yang, Dexin; Shen, Puxiu; Yu, Jingcheng; Tong, Chao; Wang, Xinzhuang
Source:
Theriogenology 2021 v.167 pp. 85-93
ISSN:
0093-691X
Subject:
interleukin-17,   etc   ; ; atherosclerosis; cattle; endometritis; endometrium; epithelial cells; gene ontology; inflammation; lipopolysaccharides; microRNA; models; parturition; phosphates; shear stress;     Show all 15 Subjects
Abstract:
... After parturition, bovine uterine stromal cells are often exposed to complex bacterial and viral stimuli owing to epithelial cell rupture, resulting in an inflammatory response. In this study, we used an in vitro model to study the response of bovine endometrial stromal cells to inflammatory mediators and the associated regulated microRNAs in response to lipopolysaccharide. Lipopolysaccharide (LPS ...
DOI:
10.1016/j.theriogenology.2021.03.012