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You searched for: Subject "interleukin-6" Remove constraint Subject: "interleukin-6"
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1. Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo

Author:
Jixuan Ma; Yujia Xie; Yiju Xu; Pei Gu; Yingdie Zhang; Lieyang Fan; Yun Zhou; Haijiao Wang; Ting Zhou; Jintong He; Dongming Wang; Weihong Chen
Source:
Journal of environmental sciences (China) 2023 v.126 pp. 772-783
ISSN:
1001-0742
Subject:
interleukin-6,   etc   ; antibodies; collagen; environmental exposure; epithelium; fibroblasts; fibrosis; gelatinase A; glycoproteins; inflammation; interleukin-11; lungs; mice; mitogen-activated protein kinase; necrosis; neoplasms; neutralization; silica; therapeutics; China;     Show all 20 Subjects
Abstract:
... Environmental exposure to crystalline silica particles can lead to silicosis, which is one of the most serious pulmonary interstitial fibrosis around the world. Unfortunately, the exact mechanism on silicosis is unclear, and the effective treatments are lacking to date. In this study, we aim to explore the molecular mechanism by which interleukin-11 (IL-11) affects silica particles-induced lung in ...
DOI:
10.1016/j.jes.2022.03.015

2. Dietary Flavonoids Alleviate Inflammation and Vascular Endothelial Barrier Dysfunction Induced by Advanced Glycation End Products In Vitro

Author:
Yishan Fu; Yijia Jia; Yilin Sun; Xiaojing Liu; Junjie Yi; Shengbao Cai
Source:
Nutrients 2022 v.14 no.5 pp. -
ISSN:
2072-6643
Subject:
interleukin-6,   etc   ; flavonoids; inflammation; profilins;     Show all 4 Subjects
Abstract:
... The aim of this study was to compare the protective effects of three dietary flavonoids (apigenin-7-O-glucoside (A7G), isorhamnetin-3-O-rutinoside (I3R), and cyanidin-3-O-glucoside (C3G)) on advanced glycation end products (AGEs)-induced inflammation and vascular endothelial dysfunction. Furthermore, the potential mechanisms of varied effects of those three dietary flavonoids were analyzed by mole ...
DOI:
10.3390/nu14051026

3. Hasubanan alkaloids with anti-inflammatory activity from Stephania longa

Author:
Hui Liu; Wan-Qin Liao; Rong-Xiao Lin; Lixia Fan; Jinyan Sun; Hong-Yuan Chen; Fang Liu; An-Ping Yang
Source:
Natural product research 2022 v.36 no.11 pp. 2800-2805
ISSN:
1478-6427
Subject:
interleukin-6,   etc   ; Stephania; anti-inflammatory activity; research;     Show all 4 Subjects
Abstract:
... Two new hasubanan alkaloids, stephalonester A (1) and stephalonester B (2), together with four known compounds, stephalonine E (3), longanone (4), cephatonine (5), and prostephabyssine (6) were isolated from the whole plant of Stephania longa. Their structures were determined by HR-ESI-MS, 1 D and 2 D NMR, ECD calculations, as well as by comparison with literature values. All compounds were evalua ...
DOI:
10.1080/14786419.2021.1928118

4. The immunomodulatory activity of degradation products of Sesbania cannabina galactomannan with different molecular weights

Author:
Yuheng Tao; Junmei Ma; Caoxing Huang; Chenhuan Lai; Zhe Ling; Qiang Yong
Source:
International journal of biological macromolecules 2022 v.205 pp. 530-538
ISSN:
0141-8130
Subject:
interleukin-6,   etc   ; Sesbania cannabina; ethanol; galactomannans; immunomodulators;     Show all 5 Subjects
Abstract:
... Galactomannan (GM) is widely recognized as an immune enhancer; however, the underlying molecular mechanism is still unknown. Herein, four products with molecular weights in descending order, namely GM40, GM50, GM65, and GMOS, were separated from incomplete degradation products of Sesbania cannabina GM by ethanol precipitation, followed by their immunomodulatory activity. Through FTIR and XPS spect ...
DOI:
10.1016/j.ijbiomac.2022.02.122

5. Bifunctional Pdots-Based Novel ECL Nanoprobe with Qualitative and Quantitative Dual Signal Amplification Characteristics for Trace Cytokine Analysis

Author:
Jinxia Liu; Xiaodi Liu; Huanhuan Chen; Luxia Yang; Aiting Cai; Haiwei Ji; Qi Wang; Xiaobo Zhou; Guo Li; Mingmin Wu; Yuling Qin; Li Wu
Source:
Analytical chemistry 2022 v.94 no.19 pp. 7115-7122
ISSN:
1520-6882
Subject:
interleukin-6,   etc   ; analytical chemistry; biomarkers; detection limit; immunosensors;     Show all 5 Subjects
Abstract:
... In this work, a novel methodology to design bifunctional ECL-luminophores with self-enhanced and TSA-amplified characteristics was proposed for improving the sensing performance of ECL-immunosensor toward trace cytokine analysis. Thanks to the qualitative- and quantitative- dual signal amplification technique, the as-prepared ECL biosensor demonstrated excellent detection performance. By analyzing ...
DOI:
10.1021/acs.analchem.2c01041

6. Biomarkers of Age-Related Frailty and Frailty Related to Diseases: An Exploratory, Cross-Sectional Analysis from the MAPT Study

Author:
D. Angioni; W. H. Lu; S. Sourdet; T. Macaron; C. Takeda; S. Guyonnet; J. F. Mangin; Y. Rolland; P. de Souto Barreto; B. Vellas; MAPT/DSA Group
Source:
The Journal of nutrition, health and aging 2022 v.26 no.6 pp. 545-551
ISSN:
1760-4788
Subject:
interleukin-6,   etc   ; biomarkers; blood; cross-sectional studies; people;     Show all 5 Subjects
Abstract:
... BACKGROUND: Frailty may in most cases result from two main causes: the aging process (age-related frailty) and diseases (evolving chronic conditions or acute medical illnesses — disease-related frailty). The biological determinants characterizing these two main causes of frailty may be different. OBJECTIVES: The aim of this study is to compare the biological and neuroimaging profile of people with ...
DOI:
10.1007/s12603-022-1793-9

7. Sensitive Protein Detection Using Site-Specifically Oligonucleotide-Conjugated Nanobodies

Author:
Rasel A. Al-Amin; Phathutshedzo M. Muthelo; Eldar Abdurakhmanov; Cécile Vincke; Shahnaz P. Amin; Serge Muyldermans; U. Helena Danielson; Ulf Landegren
Source:
Analytical chemistry 2022 v.94 no.28 pp. 10054-10061
ISSN:
1520-6882
Subject:
interleukin-6,   etc   ; analytical chemistry; antigen detection; biomarkers; sortase A;     Show all 5 Subjects
Abstract:
... High-quality affinity probes are critical for sensitive and specific protein detection, in particular for detection of protein biomarkers in the early phases of disease development. Proximity extension assays (PEAs) have been used for high-throughput multiplexed protein detection of up to a few thousand different proteins in one or a few microliters of plasma. Clonal affinity reagents can offer ad ...
DOI:
10.1021/acs.analchem.2c00584

8. Local and systemic effects of interleukin‐6 (IL‐6) in inflammation and cancer

Author:
Stefan Rose‐John
Source:
FEBS letters 2022 v.596 no.5 pp. 557-566
ISSN:
0014-5793
Subject:
interleukin-6,   etc   ; dimerization; hepatocytes; immune system; inflammation; loci; mice;     Show all 7 Subjects
Abstract:
... Interleukin‐6 (IL‐6) is an inflammatory cytokine, the level of which is highly elevated in most, if not all, inflammatory states. IL‐6 triggers cell type‐specific responses and acts on target cells via a specific interleukin‐6 receptor (IL‐6R), which, together with IL‐6, binds to and induces the dimerization of a second receptor subunit, gp130. IL‐6 also binds to soluble IL‐6R, and this complex in ...
DOI:
10.1002/1873-3468.14220

9. Human Beta Papillomavirus Type 8 E1 and E2 Proteins Suppress the Activation of the RIG-I-Like Receptor MDA5

Author:
Stephanie Rattay; Martin Hufbauer; Christian Hagen; Bastian Putschli; Christoph Coch; Baki Akgül; Gunther Hartmann
Source:
Viruses 2022 v.14 no.7 pp. -
ISSN:
1999-4915
Subject:
interleukin-6,   etc   ; RNA; humans; keratinocytes; ligands; risk; skin neoplasms;     Show all 7 Subjects
Abstract:
... Persistent infections of the skin with the human papillomavirus of genus beta (β-HPV) in immunocompetent individuals are asymptomatic, but in immunosuppressed patients, β-HPV infections exhibit much higher viral loads on the skin and are associated with an increased risk of skin cancer. Unlike with HPV16, a high-risk α-HPV, the impact of β-HPV early genes on the innate immune sensing of viral nucl ...
DOI:
10.3390/v14071361

10. IL- 6 activates pathologic Th17 cell via STAT 3 phosphorylation in inflammatory joint of Ankylosing Spondylitis

Author:
Hae-in Lee; Hui-Ju Kim; Sungsin Jo; Seung Cheol Shim; Tae-Hwan Kim; Eun Jeong Won; Tae-Jong Kim
Source:
Biochemical and biophysical research communications 2022 v.620 pp. 69-75
ISSN:
0006-291X
Subject:
interleukin-6,   etc   ; arthritis; inflammation; interferon-gamma; mice; phosphorylation; research; skeleton;     Show all 8 Subjects
Abstract:
... Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease, which is characterized by inflammation of the axial skeleton and the peripheral arthritis. An increase in the number of Th17 cells in patients with AS has been reported. Although Th17 cells have been involved in the induction of inflammation, recent data suggest that not all Th17 cells are pathogenic, showing regulatory funct ...
DOI:
10.1016/j.bbrc.2022.06.081

11. Association of three single nucleotide polymorphisms in interleukin 6 gene with risk of chronic obstructive pulmonary disease

Author:
Ying Hao; Qing Zhou; Yingtong Sun; Wenquan Niu; Juan Du
Source:
Gene 2022 v.828 pp. 146467
ISSN:
0378-1119
Subject:
interleukin-6,   etc   ; computer software; genes; loci; respiratory tract diseases; risk;     Show all 6 Subjects
Abstract:
... Experimental studies have implicated the involvement of interleukin 6 (IL6) in chronic obstructive pulmonary disease (COPD), supporting the possible association between genetic alterations in IL6 gene and risk of COPD. We aimed to examine the association of three polymorphisms in IL6 gene with COPD by integrating the summary results of available reports, and summarize the changes circulating IL6 c ...
DOI:
10.1016/j.gene.2022.146467

12. Two new stilbene glucosides and a new benzoic acid derivative from Tournefortia sibirica

Author:
Lan-Tian Cui; Zhe Jiang; Tie-Qiang Zong; Zheng-Yu Hu; Long Jin; Mei Jin; Jin-Feng Sun; Wei Zhou; Sheng-Bao Diao; Gao Li
Source:
Journal of Asian natural products research 2022 v.24 no.8 pp. 746-753
ISSN:
1477-2213
Subject:
interleukin-6,   etc   ; Tournefortia; benzoic acid; glucosides; research; spectral analysis; stilbenes;     Show all 7 Subjects
Abstract:
... Two new stilbene glucosides, trans-3,5-dihydroxy-4-methoxystilbene 3-O-β-D-glucopyranoside (1), cis-3,5-dihydroxy-4-methoxystilbene 3-O-β-D-glucopyranoside (2), one new benzoic acid derivative, cis-4-hydroxy-3-hydroxymethyl-2-butenyl benzoate 4-O-β-D-glucopyranoside (3), and four known compounds (4 − 7) were isolated from Tournefortia sibirica L. The structures of these compounds were elucidated o ...
DOI:
10.1080/10286020.2021.1983800

13. Anti-neuroinflammatory 3-hydroxycoumaronochromones and isoflavanones enantiomers from the fruits of Ficus altissima Blume

Author:
Jiaming Yao; Qiuyi Qin; Yihai Wang; Jia Zeng; Jingwen Xu; Xiangjiu He
Source:
Phytochemistry 2022 v.202 pp. 113313
ISSN:
0031-9422
Subject:
interleukin-6,   etc   ; Ficus altissima; cytotoxicity; enantiomers; figs; phytochemicals; spectral analysis;     Show all 7 Subjects
Abstract:
... A phytochemical study on the fruits of Ficus altissima Blume (lofty fig) led to the isolation and structural elucidation of three pairs of enantiomeric 3-hydroxycoumaronochromones and two pairs of enantiomeric isoflavanones, including eight undescribed compounds. Their structures were determined based on a comprehensive analysis of NMR and HR-ESI-MS spectroscopic data, calculated ¹³C NMR-DP4 plus ...
DOI:
10.1016/j.phytochem.2022.113313

14. A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro-inflammatory Cytokines of Rheumatoid Arthritis

Author:
Xiangjie Chen; Qiuyu Wu; Zheng Gong; Tengfei Ren; Qian Du; Yukang Yuan; Yibo Zuo; Ying Miao; Jiuyi He; Caixia Qiao; Zhijin Zheng; Tingting Zhang; Lin Huang; Zhijun Xie; Jun Wang; Yueping Zhu; Chuanwu Zhu; Yang Xu; Depei Wu; Fangyuan Gong; Junping Cheng; Chengping Wen; Hui Zheng
Source:
Journal of natural products 2022 v.85 no.4 pp. 1109-1117
ISSN:
1520-6025
Subject:
interleukin-6,   etc   ; T-lymphocytes; collagen; ingredients; menthone; rheumatoid arthritis; secretion;     Show all 7 Subjects
Abstract:
... Rheumatoid arthritis (RA) is an autoimmune disease with nearly 1.6 billion patients worldwide and an incidence of 0.5–1%. In recent years, basic and clinical studies have revealed that immune cell responses and corresponding secretion of inflammatory factors are important in the control of RA development. Our study found that a natural plant ingredient, menthone, could be used as a potential antir ...
DOI:
10.1021/acs.jnatprod.1c01231

15. Pro-Inflammatory and Immunological Profile of Dogs with Myxomatous Mitral Valve Disease

Author:
Diego Piantedosi; Nadia Musco; Anna Teresa Palatucci; Flavia Carriero; Valentina Rubino; Francesco Pizzo; Saad Nasir; Giuseppe Molinaro; Giuseppina Ruggiero; Giuseppe Terrazzano; Pietro Lombardi; Laura Cortese
Source:
Veterinary sciences 2022 v.9 no.7 pp. -
ISSN:
2306-7381
Subject:
interleukin-6,   etc   ; body weight; dogs; echocardiography; elderly; heart failure; leptin;     Show all 7 Subjects
Abstract:
... Myxomatous mitral valve disease (MMVD) is a very frequently acquired cardiac disease in dog breeds and is responsible for congestive heart failure (CHF). The involvement of the immune system and pro-inflammatory cytokines in dogs with CHF due to mitral valve disease has not yet been extensively investigated. Here, we investigate the role of pro-inflammatory cytokines and the dysfunction of the imm ...
DOI:
10.3390/vetsci9070326

16. Purification, structural characterization and immunomodulatory activities of a polysaccharide from the fruiting body of Morchella sextelata

Author:
Meng-Ting Kuang; Jing-Yue Xu; Jin-Yu Li; Liu Yang; Bo Hou; Qi Zhao; Jiang-Miao Hu
Source:
International journal of biological macromolecules 2022 v.213 pp. 394-403
ISSN:
0141-8130
Subject:
interleukin-6,   etc   ; Morchella; glucose; mannose; methylation; molecular weight; phagocytosis; polysaccharides;     Show all 8 Subjects
Abstract:
... A novel polysaccharide (MSP-1) was isolated from the fruiting body of Morchella sextelata and purified using DEAE-52 and Sephadex G-75. The molecular weight of MSP-1 was 1.17 × 10⁴ Da, as detected by HPLC analysis. The monosaccharide composition of MSP-1 was mannose and glucose at a ratio of 1.00: 1.25. Methylation and NMR results revealed that the backbone of MSP-1 was composed of →4)-β-D-Manp-(1 ...
DOI:
10.1016/j.ijbiomac.2022.05.096

17. Inflammatory markers in response to interval and continuous exercise in obese women

Author:
A. Andarianto; P.S. Rejeki; Sakina; A. Pranoto; T.W. Aga Seputra; Sugiharto; M. Miftahussurur
Source:
Comparative exercise physiology 2022 v.18 no.2 pp. 135-142
ISSN:
1755-2559
Subject:
interleukin-6,   etc   ; exercise; inflammation; lifestyle; necrosis; neoplasms; obesity; secretion; t-test;     Show all 9 Subjects
Abstract:
... Obesity is strongly associated with the degree of inflammation characterised by proinflammatory cytokines, such as tumour necrosis factor-α (TNF-α). Lifestyle modification with exercise is the right strategy because it can stimulate interleukin 6 (IL-6) secretion which acts as an anti-inflammatory. This study aimed to analyse the response of interval and continuous exercise to inflammatory markers ...
DOI:
10.3920/CEP210038

18. Perspectives on Populus spp. (Salicaceae) bud extracts as antioxidant and anti-inflammatory agents

Author:
Elisa Pannucci; Donatella D’Eliseo; Francesca Ieri; Annalisa Romani; Luca Santi; Roberta Bernini; Maurizio Sabatti; Francesca Velotti
Source:
Natural product research 2022 v.36 no.6 pp. 1648-1652
ISSN:
1478-6427
Subject:
interleukin-6,   etc   ; anti-inflammatory activity; antioxidant activity; antioxidants; nucleoproteins; research; therapeutics;     Show all 7 Subjects
Abstract:
... Hydroalcoholic extracts obtained from buds of P. nigra, P. deltoides and P. trichocarpa were characterized by HPLC-DAD-MS analysis and subsequently evaluated in vitro for their antioxidant and anti-inflammatory activities. ABTS and DPPH assays evidenced that P. nigra showed the best antioxidant activity in line with its highest total phenolic content. The analysis of the anti-inflammatory activity ...
DOI:
10.1080/14786419.2021.1896512

19. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-ɑ/AKT/p70S6 kinase signaling

Author:
Jang-Hyuk Yun; Da-Hye Lee; Han-Seok Jeong; Seung-Hoon Kim; Sang-Kyu Ye; Chung-Hyun Cho
Source:
Biochemical and biophysical research communications 2022 v.613 pp. 133-139
ISSN:
0006-291X
Subject:
interleukin-6,   etc   ; apoptosis; diabetic retinopathy; gene expression; inflammation; neuroglia; research; therapeutics;     Show all 8 Subjects
Abstract:
... Diabetic retinopathy (DR) is one of the vascular complications associated with diabetes mellitus. Pericyte loss is an early characteristic phenomenon in DR. However, the mechanism by which pericyte apoptosis occurs in DR is not fully understood. We have focused on the increased STAT3 activation in diabetic retinas because STAT3 activation is associated with inflammation, and persistent chronic inf ...
DOI:
10.1016/j.bbrc.2022.05.004

20. IL- 6 protects cardiomyocytes from oxidative stress at the early stage of LPS-induced sepsis

Author:
Yue Peng; Qingchen Yang; Shuya Gao; Zekun Liu; Weixian Kong; Xiaohong Bian; Zhe Li; Junmei Ye
Source:
Biochemical and biophysical research communications 2022 v.603 pp. 144-152
ISSN:
0006-291X
Subject:
interleukin-6,   etc   ; antioxidants; cardiomyocytes; histology; homeostasis; oxidative stress; protective effect; research;     Show all 8 Subjects
Abstract:
... Pro-inflammatory cytokines play important roles in sepsis-induced cardiac injury. Among various cytokines, the function of Interleukin-6 (IL-6) in the regulation of cardiomyocyte injury remains to be elucidated. This study aimed to investigate whether IL-6 plays a key role in the sepsis-induced cardiomyocyte injury and the possible mechanism. Mice deficient for Il-6 exhibited impaired heart rhythm ...
DOI:
10.1016/j.bbrc.2022.03.013