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1. Detection of bovine inflammatory cytokines IL-1β, IL-6, and TNF-α with a multiplex electrochemiluminescent assay platform

Author:
Chitko-McKown, Carol G.; Bierman, Stacy L.; Kuehn, Larry A.; Bennett, Gary L.; DeDonder, Keith D.; Apley, Michael D.; Harhay, Gregory P.; Clawson, Michael L.; White, Bradley J.; Larson, Robert L.; Capik, Sarah F.; Lubbers, Brian V.
Source:
Veterinary immunology and immunopathology 2021 v.237 pp. 110274
ISSN:
0165-2427
Subject:
interleukin-6,   etc   ; cattle; immunopathology;     Show all 3 Subjects
Abstract:
... Commercially available bovine-specific assays are limited in number, and multiplex assays for this species are rare. Our objective was to develop a multiplex assay for the bovine inflammatory cytokines IL-1β, IL-6, and TNF-α using the Meso Scale Discovery U-PLEX platform. "Do-It-Yourself" ELISA kits that contained polyclonal antibodies, both unlabeled and biotinylated, and the specific recombinant ...
DOI:
10.1016/j.vetimm.2021.110274

2. Lacto-N-fucopentaose-III ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model

Author:
Brown, Kyle A.; Carpenter, Jessica M.; Preston, Collin J.; Ludwig, Helaina D.; Clay, Kendall B.; Harn, Donald A.; Norberg, Thomas; Wagner, John J.; Filipov, Nikolay M.
Source:
Life sciences 2021 pp. 119707
ISSN:
0024-3205
Subject:
interleukin-6,   etc   ; ; electrophysiology; hippocampus; immunotherapy; mice; neuroplasticity; remission; synaptic transmission;     Show all 9 Subjects
Abstract:
... The present study investigated if treatment with the immunotherapeutic, lacto-N-fucopentaose-III (LNFPIII), resulted in amelioration of acute and persisting deficits in synaptic plasticity and transmission as well as trophic factor expression along the hippocampal dorsoventral axis in a mouse model of Gulf War Illness (GWI).Mice received either coadministered or delayed LNFPIII treatment throughou ...
DOI:
10.1016/j.lfs.2021.119707

3. Peripheral blood cultured mast cells: Phenotypic and functional outcomes of different culture protocols

Author:
Elst, Jessy; Sabato, Vito; van der Poorten, Marie-Line M.; Faber, Margaretha; Van Gasse, Athina L.; De Puysseleyr, Leander P.; Bridts, Chris H.; Mertens, Christel; Van Houdt, Michel; Maurer, Marcus; Hagendorens, Margo M.; Ebo, Didier G.
Source:
Journal of immunological methods 2021 v.492 pp. 113003
ISSN:
0022-1759
Subject:
interleukin-6,   etc   ; blood; crosslinking; humans; phenotype; substance P;     Show all 6 Subjects
Abstract:
... Mast cells (MCs) play a pivotal role in innate and adaptive immune responses. However, MCs are also involved in different pathologic conditions. Studies on the mechanisms that govern human MC functions are impeded by their limited and difficult recovery. Therefore, several research groups have developed protocols to culture human MCs from progenitor cells. These protocols vary with respect to cult ...
DOI:
10.1016/j.jim.2021.113003

4. Anti-rheumatoid arthritis potential of diterpenoid fraction derived from Rhododendron molle fruits

Author:
HE, Yan-Chen; YAO, Yu-Min; XUE, Qiu-Wen; FANG, Xin; LIANG, Shuang
Source:
Chinese journal of natural medicines 2021 v.19 no.3 pp. 181-187
ISSN:
1875-5364
Subject:
interleukin-6,   etc   ; Rhododendron; diterpenoids; phytochemicals; rats; rheumatoid arthritis; therapeutics;     Show all 7 Subjects
Abstract:
... Rhododendron molle G. Don is first recorded in Shengnong’s Herbal Classic, and its fruits, which are termed as Liuzhouzi, are often used to treat rheumatoid arthritis in Chinese folk. During our ongoing investigation to develop a safer and potential new arthritis therapy, a process for the preparation of diterpenoid fraction from Rhododendron mollefruits was established. In order to evaluate the m ...
DOI:
10.1016/S1875-5364(21)60019-5

5. HUCMSCs transplantation combined with ultrashort wave therapy attenuates neuroinflammation in spinal cord injury through NUR77/ NF-κB pathway

Author:
Wang, Shuai; Jia, Yiying; Cao, Xiangyan; Feng, Sining; Na, Li; Dong, Hongxuan; Gao, Jian; Zhang, Lixin
Source:
Life sciences 2021 v.267 pp. 118958
ISSN:
0024-3205
Subject:
interleukin-6,   etc   ; animal injuries; astrocytes; humans; rats; therapeutics; umbilical cord;     Show all 7 Subjects
Abstract:
... Spinal cord injury (SCI) is a major cause of long-term physical impairment. Currently, treatment for SCI is limited to supportive measures, which can lead to permanent disability, representing a serious social burden. The present study aimed to evaluate the inflammatory microenvironment effects of human umbilical cord mesenchymal stem cells (HUCMSCs)+ Ultrashort Wave (USW) therapy on SCI and revea ...
DOI:
10.1016/j.lfs.2020.118958

6. Effect of non-encapsulated and encapsulated active dried yeast on blood cell count, blood metabolites, and immune response of finishing beef heifers

Author:
Jiao, Peixin; Beauchemin, Karen A.; Ma, Fengchun; AlZahal, Ousama; Xie, Xiaolai; Yang, Wenzhu
Source:
Canadian journal of animal science 2021 v.101 no.2 pp. 390-394
ISSN:
0008-3984
Subject:
interleukin-6,   etc   ; beef; erythrocytes; immune response; metabolites; urea nitrogen; yeasts;     Show all 7 Subjects
Abstract:
... A study was conducted to evaluate whether encapsulated active dried yeast (EDY), compared with non-protected active dried yeast (ADY) or antibiotics (ANT), improved immune response and blood metabolites of finishing beef heifers. Blood urea nitrogen was lower (P < 0.05) with supplemented ADY and mixture of ADY and EDY (MDY) compared with control. Supplementation of MDY also resulted in lower (P <  ...
DOI:
10.1139/cjas-2020-0160

7. Increased circulating CD31+/CD42b-EMPs in Perthes disease and inhibit HUVECs angiogenesis via endothelial dysfunction

Author:
Li, Boxiang; Huang, Qian; Lin, Chengsen; Lu, Rongbin; Wang, Tiantian; Chen, Xianxiang; Liu, Zhengtang; Liu, Yun; Wu, Jianping; Wu, Yang; Liao, Shijie; Ding, Xiaofei
Source:
Life sciences 2021 v.265 pp. 118749
ISSN:
0024-3205
Subject:
interleukin-6,   etc   ; angiogenesis; apoptosis; biomarkers; flow cytometry; phenotype; secretion;     Show all 7 Subjects
Abstract:
... Endothelial microparticles (EMPs) are extracellular vesicles secreted by endothelial cells. The purpose of this research is to explore that the clinical significance and roles in angiogenesis and endothelial dysfunction of circulating microparticles in Perthes disease.We collected platelet-poor plasma (PPP) from patients and controls, then microparticles (MPs) were extracted. Flow cytometry was pe ...
DOI:
10.1016/j.lfs.2020.118749

8. Effects of 14-weeks betaine supplementation on pro-inflammatory cytokines and hematology status in professional youth soccer players during a competition season: a double blind, randomized, placebo-controlled trial

Author:
Nobari, Hadi; Cholewa, Jason M.; Pérez-Gómez, Jorge; Castillo-Rodríguez, Alfonso
Source:
Journal of the International Society of Sports Nutrition 2021 v.18 no.1 pp. 42
ISSN:
1550-2783
Subject:
interleukin-6,   etc   ; betaine; hematology; hemoglobin; immune response; placebos; secretion; sports; tumor necrosis factor-alpha; youth;     Show all 10 Subjects
Abstract:
... OBJECTIVE: Systemic elevations in pro-inflammatory cytokines are a marker of non-functional over reaching, and betaine has been shown to reduce the secretion of pro-inflammatory cytokines in vitro. The aim of this study was to investigate the effects of betaine supplementation on tumor necrosis factor alpha (TNF-α), interleukins-1 beta (IL-1β), − 6 (IL-6) and the complete blood cell (CBC) count in ...
DOI:
10.1186/s12970-021-00441-5

9. The effect of Omega-3 polyunsaturated fatty acid supplementation on exercise-induced muscle damage

Author:
Kyriakidou, Yvoni; Wood, Carly; Ferrier, Chrystalla; Dolci, Alberto; Elliott, Bradley
Source:
Journal of the International Society of Sports Nutrition 2021 v.18 no.1 pp. 9
ISSN:
1550-2783
Subject:
interleukin-6,   etc   ; creatine kinase; exercise; inflammation; muscles; omega-3 fatty acids; placebos;     Show all 7 Subjects
Abstract:
... BACKGROUND: Exercise-induced muscle damage (EIMD) results in transient muscle inflammation, strength loss, muscle soreness and may cause subsequent exercise avoidance. Omega-3 (n-3) supplementation may minimise EIMD via its anti-inflammatory properties, however, its efficacy remains unclear. METHODS: Healthy males (n = 14, 25.07 ± 4.05 years) were randomised to 3 g/day n-3 supplementation (N-3, n  ...
DOI:
10.1186/s12970-020-00405-1

10. Clinical efficacy of eucaloric ketogenic nutrition in the COVID-19 cytokine storm: A retrospective analysis of mortality and intensive care unit admission

Author:
Sukkar, Samir Giuseppe; Cogorno, Ludovica; Pisciotta, Livia; Pasta, Andrea; Vena, Antonio; Gradaschi, Raffaella; Dentone, Chiara; Guiddo, Erica; Martino, Eleonora; Beltramini, Sabrina; Donini, Lorenzo Maria; Carmisciano, Luca; Sormani, Maria Pia; Bassetti, Matteo
Source:
Nutrition 2021 v.89 pp. 111236
ISSN:
0899-9007
Subject:
interleukin-6,   etc   ; COVID-19 infection; ketogenic diet; mortality; multivariate analysis; retrospective studies; therapeutics;     Show all 7 Subjects
Abstract:
... Objectives: Our primary objective was to explore the effect of a eucaloric ketogenic diet (EKD) on mortality, admission to the intensive care unit, and need for non-invasive ventilation in hospitalized patients with COronaVIrus Disease 19 (COVID-19), in comparison to a eucaloric standard diet. Secondary objectives were verification of the safety and feasibility of the diet and its effects on infla ...
DOI:
10.1016/j.nut.2021.111236

11. Structural characterization and immunomodulatory activity of a glucan from Radix Codonopsis

Author:
Li, Jiankuan; Wang, Yan; Ji, Jiaojiao; Cao, Lingya; Bai, Yune; Gao, Jianping
Source:
Journal of functional foods 2021 v.83 pp. 104537
ISSN:
1756-4646
Subject:
interleukin-6,   etc   ; Codonopsis pilosula; equations; glucans; human health; immunity; immunomodulators; interleukin-10; molecular weight;     Show all 9 Subjects
Abstract:
... A glucan named as CPC was obtained from the roots of Codonopsis pilosula and its structure was determined by HPGPC, IR, GC–MS, and NMR. HPGPC showed that CPC was a homogeneous polysaccharide and exhibited a molecular weight (Mp) of 1698 Da according to the equation of standard molecular weight (lg Mp = −0.1869 tR + 9.7386). The results from NMR and GC–MS demonstrated that the main linkages in CPC ...
DOI:
10.1016/j.jff.2021.104537

12. Allogenic mesenchymal stem cell-conditioned medium does not affect sperm parameters and mitigates early endometrial inflammatory responses in mares

Author:
Tongu, Eriky Akio de Oliveira; Segabinazzi, Lorenzo G.T.M.; Alvarenga, Marina Landim; Monteiro, Aldine; Papa, Frederico Ozanam; Alvarenga, Marco Antonio
Source:
Theriogenology 2021 v.169 pp. 1-8
ISSN:
0093-691X
Subject:
interleukin-6,   etc   ; endometritis; endometrium; insemination; interleukin-10; milk; neutrophils; ovulation; plasma membrane; pregnancy; semen; spermatozoa; ultrasonography;     Show all 13 Subjects
Abstract:
... This study aimed to evaluate the effects of mesenchymal stem cell-conditioned medium (MSC-CM) on sperm parameters, intrauterine polymorphonuclear neutrophils (PMN), intrauterine fluid accumulation (IUF), and fertility in mares. In experiment 1, two ejaculates from ten stallions were extended to 50 million sperm/mL using a milk-based extender. Thereafter, 20 mL of extended semen was added of MSC-CM ...
DOI:
10.1016/j.theriogenology.2021.03.019

13. Activation of TREM-1 induces endoplasmic reticulum stress through IRE-1α/XBP-1s pathway in murine macrophages

Author:
Dong, Liang; Tan, Cheng-Wei; Feng, Peng-Jiu; Liu, Fu-Bing; Liu, De-Xing; Zhou, Jun-Jie; Chen, Yan; Yang, Xin-Xin; Zhu, Yu-Hang; Zhu, Zhao-Qiong
Source:
Molecular immunology 2021 v.135 pp. 294-303
ISSN:
0161-5890
Subject:
interleukin-6,   etc   ; agonists; antibodies; endoplasmic reticulum; endoplasmic reticulum stress; inflammation; lipopolysaccharides; lungs; macrophages; mice;     Show all 10 Subjects
Abstract:
... Increasing evidence suggests that endoplasmic reticulum (ER) stress activates several pro-inflammatory signaling pathways in many diseases, including acute lung injury (ALI). We have reported that blocking triggering receptor expressed on myeloid cells 1 (TREM-1) protects against ALI by suppressing pulmonary inflammation in mice with ALI induced by lipopolysaccharides (LPS). However, the molecular ...
DOI:
10.1016/j.molimm.2021.04.023

14. Influence of UV/H2O2 treatment on polysaccharides from Sargassum fusiforme: Physicochemical properties and RAW 264.7 cells responses

Author:
Chen, Xiaoyong; You, Lijun; Ma, Yongxuan; Zhao, Zhengang; Kulikouskaya, Viktoryia
Source:
Food and chemical toxicology 2021 v.153 pp. 112246
ISSN:
0278-6915
Subject:
interleukin-6,   etc   ; Sargassum fusiforme; anti-inflammatory activity; interleukin-12; macroalgae; polysaccharides; sulfates; toxicity; toxicology; uronic acids;     Show all 10 Subjects
Abstract:
... There are few studies on seaweed polysaccharides with UV/H₂O₂ treatment, so the aim of this study was to evaluate the effects of UV/H₂O₂ treatment on physicochemical properties and RAW 264.7 cells responses of polysaccharides from Sargassum fusiforme (PSF). Results showed that the contents of reducing sugar and sulfate in PSF with UV/H₂O₂ treatment for 2 h increased by 202.86% and 31.77%, respecti ...
DOI:
10.1016/j.fct.2021.112246

15. Secondary metabolites from Scutellaria brevibracteata subsp. subvelutina and their in vitro anti-inflammatory activities

Author:
Erdoğan, Murat; Konya, Rima; Özhan, Yağmur; Sipahi, Hande; Çinbilgel, İlker; Masullo, Milena; Piacente, Sonia; Kırmızıbekmez, Hasan
Source:
South African journal of botany 2021 v.139 pp. 12-18
ISSN:
0254-6299
Subject:
interleukin-6,   etc   ; Scutellaria; catalpol; chemotaxonomy; indomethacin; luteolin; macrophages; nitrites; secondary metabolites;     Show all 9 Subjects
Abstract:
... From the MeOH extract of the aerial parts of Scutellaria brevibracteata subsp. subvelutina 12 secondary metabolites including eight iridoid glycosides (1-8), three flavonoids (9-11) and one phenylethanoid glycoside (12) were isolated. Their structures were elucidated as catalpol (1), globularin (2), scutellarioside II (3), picroside III (4), pensteminoside (5), 8-epiloganic acid (6), albidoside (7 ...
DOI:
10.1016/j.sajb.2021.01.028

16. Probiotic Escherichia coli Nissle inhibits IL-6 and MAPK-mediated cardiac hypertrophy during STZ-induced diabetes in rats

Author:
Chiang, C.J.; Chao, Y.P.; Ali, A.; Day, C.H.; Ho, T.J.; Wang, P.N.; Lin, S.C.; Padma, V.V.; Kuo, W.W.; Huang, C.Y.
Source:
Beneficial microbes 2021 v.12 no.3 pp. 283-293
ISSN:
1876-2891
Subject:
interleukin-6,   etc   ; Escherichia coli; body weight; diabetes; echocardiography; fluorescent antibody technique; hypertrophy; males; natriuretic peptides; probiotics;     Show all 10 Subjects
Abstract:
... Escherichia coli Nissle (EcN), a probiotic bacterium protects against several disorders. Multiple reports have studied the pathways involved in cardiac hypertrophy. However, the effects of probiotic EcN against diabetes-induced cardiac hypertrophy remain to be understood. We administered five weeks old Wistar male (271±19.4 g body weight) streptozotocin-induced diabetic rats with 10⁹ cfu of EcN vi ...
DOI:
10.3920/BM2020.0094

17. Protective effects of prucalopride in MPTP-induced Parkinson’s disease mice: Neurochemistry, motor function and gut barrier

Author:
Shi, Yun; Qiao, Chen-Meng; Zhou, Yu; Wu, Ji; Cui, Chun; Hong, Hui; Jia, Xue-Bing; Huang, Shu-Bing; Yao, Li; Zhao, Wei-Jiang; Shen, Yan-Qin
Source:
Biochemical and biophysical research communications 2021 v.556 pp. 16-22
ISSN:
0006-291X
Subject:
interleukin-6,   etc   ; absorption barrier; agonists; constipation; dopamine; intestines; intraperitoneal injection; mice; research;     Show all 9 Subjects
Abstract:
... Evidence suggests constipation precedes motor dysfunction and is the most common gastrointestinal symptom in Parkinson’s disease (PD). 5-HT4 receptor (5-HT4R) agonist prucalopride has been approved to treat chronic constipation. Here, we reported intraperitoneal injection of prucalopride for 7 days increased dopamine and decreased dopamine turnover. Prucalopride administration improved motor defic ...
DOI:
10.1016/j.bbrc.2021.03.109

18. The role of STIM1/ORAI1 channel in the analgesic effect of grain-sized moxibustion on inflammatory pain mice model

Author:
Zhang, Cheng-shun; Zuo, Chuan-yi; Lv, Peng; Zhang, Han-xiao; Lin, Si-rui; Huang, Rui-zhen; Shi, Gang; Dai, Xiao-qin
Source:
Life sciences 2021 pp. 119699
ISSN:
0024-3205
Subject:
interleukin-6,   etc   ; ; Western blotting; analgesia; analgesic effect; blood serum; fluorescent antibody technique; heat; pain; temperature;     Show all 10 Subjects
Abstract:
... The therapeutic effect of grain-sized moxibustion (GS-Moxi) on inflammatory pain has been well recognized clinically, but the mechanism remains unclear. STIM1/ORAI1 is a sensible temperature channel, therefore; this study aimed to investigate the analgesic effect of GS-Moxi and the association with STIM1/ORAI1 expression. CFA-induced inflammatory pain model was established and was treated with GS- ...
DOI:
10.1016/j.lfs.2021.119699

19. Changes in iron metabolism centered on hepcidin due to high-intensity exercise under restricted food intake

Author:
Kobayashi, Yukiko; Tanizawa, Midori; Ogata, Midori; Aoi, Wataru; Kuwahata, Masashi
Source:
Nutrition 2021 v.86 pp. 111179
ISSN:
0899-9007
Subject:
interleukin-6,   etc   ; anemia; blood serum; erythropoietin; excretion; exercise; food intake; hepcidin; iron absorption; males; transferrin;     Show all 11 Subjects
Abstract:
... The purpose of this study was to observe changes in iron metabolism of rats due to high-intensity exercise during reduced food intake.Thirty-six, 4-wk-old male Wistar rats were divided into six groups after being acclimated to running: rested control, intense exercise, 80% feeding and rested, 80% feeding and intense exercise, 70% feeding diet and rested, and 70% feeding and intense exercise groups ...
DOI:
10.1016/j.nut.2021.111179

20. Esculetin protects against early sepsis via attenuating inflammation by inhibiting NF-κB and STAT1/STAT3 signaling

Author:
CHENG, Yao-Jun; TIAN, Xin-Lei; ZENG, Ya-Zhi; LAN, Nan; GUO, Ling-Feng; LIU, Ke-Feng; FANG, Hui-Long; FAN, Hong-Ye; PENG, Zhong-Lu
Source:
Chinese journal of natural medicines 2021 v.19 no.6 pp. 432-441
ISSN:
1875-5364
Subject:
interleukin-6,   etc   ; anti-inflammatory activity; cortex; inflammation; innate immunity; lungs; macrophages; medicinal plants; therapeutics;     Show all 9 Subjects
Abstract:
... Esculetin, a natural derivative from the traditional and widely-used Chinese medicinal herb Cortex Fraxini, has a variety of pharmacological effects, especially in anti-inflammation. However, it is not clear whether esculetin has a therapeutic effect on sepsis. This study aimed to investigate the anti-inflammatory and protective effects of esculetin on early sepsis. The results showed that the lun ...
DOI:
10.1016/S1875-5364(21)60042-0