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1. Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes

Author:
Chen, Zhuo; Yuan, Shen-Jun; Li, Ke; Zhang, Quan; Li, Tong-Fei; An, Hui-Chao; Xu, Hua-Zhen; Yue, Yuan; Han, Min; Xu, Yong-Hong; Komatsu, Naoki; Zhao, Li; Chen, Xiao
Source:
Journal of controlled release 2020 v.320 pp. 469-483
ISSN:
0168-3659
Subject:
interleukin-6,   etc   ; apoptosis; astrocytes; drug therapy; glioblastoma; macrophages;     Show all 6 Subjects
Abstract:
... Astrocytes are key stromal components in glioblastoma (GBM) and have complex interactions with the GBM cells (GBC) promoting the survival, progression and therapy resistance of GBM. In this study, we first demonstrated the existence of a reciprocal activation loop mediated by the STAT3/IL-6 signaling between GBC and astrocytes. This loop of reciprocity was found to be initiated by the constitutive ...
DOI:
10.1016/j.jconrel.2020.01.044

2. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Author:
Blanco-Melo, Daniel; Nilsson-Payant, Benjamin E.; Liu, Wen-Chun; Uhl, Skyler; Hoagland, Daisy; Møller, Rasmus; Jordan, Tristan X.; Oishi, Kohei; Panis, Maryline; Sachs, David; Wang, Taia T.; Schwartz, Robert E.; Lim, Jean K.; Albrecht, Randy A.; tenOever, Benjamin R.
Source:
Cell 2020 v.181 no.5 pp. 1036-1045.e9
ISSN:
0092-8674
Subject:
interleukin-6,   etc   ; Coronavirus infections; animal models; blood serum; chemokines; inflammation; interferons; pandemic; patients; transcription (genetics); viruses;     Show all 11 Subjects
Abstract:
... Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 compared with other respiratory viruses. Cell and animal models of SARS-CoV-2 infecti ...
DOI:
10.1016/j.cell.2020.04.026

3. Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

Author:
Zhang, Chi; Wu, Zhao; Li, Jia-Wen; Zhao, Hong; Wang, Gui-Qiang
Source:
International journal of antimicrobial agents 2020 v.55 no.5 pp. 105954
ISSN:
0924-8579
Subject:
interleukin-6,   etc   ; Coronavirus infections; antagonists; death; drugs; mortality; patients; people; signal transduction; viral pneumonia; China;     Show all 11 Subjects
Abstract:
... Since December 2019, a viral pneumonia, named coronavirus disease 2019 (COVID-19), from Wuhan, China, has swept the world. Although the case fatality rate is not high, the number of people infected is large and there is still a large number of patients dying. With the collation and publication of more and more clinical data, a large number of data suggest that there are mild or severe cytokine sto ...
DOI:
10.1016/j.ijantimicag.2020.105954
PubMed:
32234467
PubMed Central:
PMC7118634

4. Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway

Author:
Wang, Bin; Xu, Heshan; Hu, Xiaoyin; Ma, Wenyu; Zhang, Jian; Li, Yuanfeng; Yu, Min; Zhang, Yaru; Li, Xuegang; Ye, Xiaoli
Source:
Life sciences 2020 v.245 pp. 117387
ISSN:
0024-3205
Subject:
interleukin-6,   etc   ; apoptosis; breast neoplasms; daidzein; epinephrine; exercise; mitochondria; natural killer cells; neoplasm cells; signal transduction;     Show all 10 Subjects
Abstract:
... The aim of this study was to investigate the inhibition of daidzein or/and regular exercise on breast cancer and to reveal the potential biological mechanisms. BALB/c mice pretreated with regular exercise training for 20 days (15 m/min, 60 min/d) were orthotopically transplanted with mouse breast cancer cells (4T1), and then treated with daidzein (145 mg/kg) by gavage for another 22 days. Results ...
DOI:
10.1016/j.lfs.2020.117387

5. Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner

Author:
Willis, Emily F.; MacDonald, Kelli P.A.; Nguyen, Quan H.; Garrido, Adahir Labrador; Gillespie, Ellen R.; Harley, Samuel B.R.; Bartlett, Perry F.; Schroder, Wayne A.; Yates, Abi G.; Anthony, Daniel C.; Rose-John, Stefan; Ruitenberg, Marc J.; Vukovic, Jana
Source:
Cell 2020 v.180 no.5 pp. 833-846.e16
ISSN:
0092-8674
Subject:
interleukin-6,   etc   ; adults; brain; brain damage; cognition; cognitive disorders; mice; neonates; neurogenesis; neuroglia; neurons; phenotype;     Show all 12 Subjects
Abstract:
... Cognitive dysfunction and reactive microglia are hallmarks of traumatic brain injury (TBI), yet whether these cells contribute to cognitive deficits and secondary inflammatory pathology remains poorly understood. Here, we show that removal of microglia from the mouse brain has little effect on the outcome of TBI, but inducing the turnover of these cells through either pharmacologic or genetic appr ...
DOI:
10.1016/j.cell.2020.02.013

6. Associations of polymorphisms in IL-6 and IL-18 with tuberculosis: Evidence from a meta-analysis

Author:
He, Chenyan; Liu, Li
Source:
Microbial pathogenesis 2020 v.139 pp. 103823
ISSN:
0882-4010
Subject:
interleukin-6,   etc   ; Asians; alleles; genetic polymorphism; interleukin-18; meta-analysis; tuberculosis;     Show all 7 Subjects
Abstract:
... Associations between polymorphisms in interleukin-6 (IL-6)/interleukin-18 (IL-18) and tuberculosis (TB) were already reported by many publications. The aim of this meta-analysis was to better clarify associations between polymorphisms in IL-6/IL-18 and TB by combing the results of all relevant publications.Eligible publications were searched from Pubmed, Embase, WOS and CNKI. We used Review Manage ...
DOI:
10.1016/j.micpath.2019.103823

7. Multi-walled carbon nanotubes (MWCNTs) transformed THP-1 macrophages into foam cells: Impact of pulmonary surfactant component dipalmitoylphosphatidylcholine

Author:
Lin, Jinru; Jiang, Ying; Luo, Yingmei; Guo, Hao; Huang, Chaobo; Peng, Jinfeng; Cao, Yi
Source:
Journal of hazardous materials 2020 v.392 pp. 122286
ISSN:
0304-3894
Subject:
interleukin-6,   etc   ; biomarkers; carbon nanotubes; carboxylation; coatings; foam cells; hydroxylation; lipids; lipogenesis; oxidative stress; proteins; signal transduction; surfactants;     Show all 13 Subjects
Abstract:
... Pulmonary surfactant or its components can function as barriers toward nanomaterials (NMs) entering pulmonary systems. However, since pulmonary surfactant mainly consists of lipids, it may be necessary to investigate the effects of co-exposure to NMs and pulmonary surfactant or its components on lipid metabolism and related signaling pathways. Recently we found that multi-walled carbon nanotubes ( ...
DOI:
10.1016/j.jhazmat.2020.122286

8. TAOK1 positively regulates TLR4-induced inflammatory responses by promoting ERK1/2 activation in macrophages

Author:
Zhu, Lingxi; Yu, Qingzhuo; Gao, Peng; Liu, Qianru; Luo, Xiaogang; Jiang, Guixian; Ji, Ruihua; Yang, Rui; Ma, Xianwei; Xu, Jing; Yuan, Hongbin; Zhou, Jun; An, Huazhang
Source:
Molecular immunology 2020 v.122 pp. 124-131
ISSN:
0161-5890
Subject:
interleukin-6,   etc   ; amino acids; endotoxins; inflammation; interleukin-12; macrophages; mice; mitogen-activated protein kinase; tumor necrosis factor-alpha;     Show all 9 Subjects
Abstract:
... Thousand and one amino acid kinase 1 (TAOK1) is a member of Ste20-like kinases, but its function in regulating inflammatory responses remains largely unknown. In this study, we identify TAOK1 as a positive regulator of TLR4-triggered inflammatory responses in macrophages. TAOK1 increases LPS-induced production of pro-inflammatory cytokine such as IL-6, TNF-α and IL12p40 in macrophages. TAOK1 defic ...
DOI:
10.1016/j.molimm.2020.04.006

9. IL- 6 and IL-8 are involved in JMJD2A-regulated malignancy of ovarian cancer cells

Author:
Zhang, Haiyu; Wang, Zichao; Wang, Fengxia; Wang, Chengdong; Zhang, Hui
Source:
Archives of biochemistry and biophysics 2020 v.684 pp. 108334
ISSN:
0003-9861
Subject:
interleukin-6,   etc   ; animal ovaries; cisplatin; histone code; interleukin-8; messenger RNA; neoplasm cells; ovarian neoplasms; screening; therapeutics; tissues;     Show all 11 Subjects
Abstract:
... Emerging evidence shows that histone modification and its related regulators are involved in the progression and chemoresistance of ovarian cancer (OC) cells. Our present study found that the expression of Jumonji C domain-containing 2A (JMJD2A), while not JMJD2B or JMJD2C, is increased in OC cells and tissues as compared with that in their corresponding controls. Knockdown of JMJD2A can decrease ...
DOI:
10.1016/j.abb.2020.108334

10. Conservation of eATP perception throughout multicellular animal evolution: Identification and functional characterization of coral and amphioxus P2X7-like receptors and flounder P2X7 receptor

Author:
Duan, Huimin; Ni, Shousheng; Yang, Shuaiqi; Zhou, Yang; Zhang, Yu; Zhang, Shicui
Source:
Developmental and comparative immunology 2020 v.106 pp. 103641
ISSN:
0145-305X
Subject:
interleukin-6,   etc   ; adenosine triphosphate; corals; flounder; humans; interleukin-1beta; interleukin-8; phagocytosis; plasma membrane; receptors; signal transduction;     Show all 11 Subjects
Abstract:
... Perception of extracellular ATP (eATP), a common endogenous damage-associated molecular pattern, is through its receptor P2X7R. If eATP/P2X7R signaling is conserved throughout animal evolution is unknown. Moreover, little information is currently available regarding P2X7R in invertebrates. Here we demonstrated that the coral P2X7-like receptor, AdP2X7RL, the amphioxus P2X7-like receptor, BjP2X7RL ...
DOI:
10.1016/j.dci.2020.103641

11. IL- 6/STAT3 mediates the HPV18 E6/E7 stimulated upregulation of MALAT1 gene in cervical cancer HeLa cells

Author:
Hao, Yunpeng; Yan, Zhinan; Zhang, Aowei; Hu, Shiyue; Wang, Nan; Luo, Xue-Gang; Ma, Wenjian; Zhang, Tong-Cun; He, Hongpeng
Source:
Virus research 2020 v.281 pp. 197907
ISSN:
0168-1702
Subject:
interleukin-6,   etc   ; etiological agents; gene expression regulation; genes; human cell lines; luciferase; neoplasm cells; non-coding RNA; uterine cervical neoplasms;     Show all 9 Subjects
Abstract:
... MALAT1, a long non-coding RNA, is highly expressed in cervical cancer cells and plays an important role in the development of cervical cancer. However, the mechanism for the excessive expression of MALAT1 in cervical cancer remains unclear. High-risk HPVs are causative agents of cervical cancer and the IL-6/STAT3 signaling is closely correlated with the development of various cancers including cer ...
DOI:
10.1016/j.virusres.2020.197907

12. The mechanism of the reduction in allergenic reactivity of bovine α-lactalbumin induced by glycation, phosphorylation and acetylation

Author:
Liu, Jun; Chen, Wen-mei; Shao, Yan-hong; Zhang, Jia-li; Tu, Zong-cai
Source:
Food chemistry 2020 v.310 pp. 125853
ISSN:
0308-8146
Subject:
interleukin-6,   etc   ; acetylation; allergenicity; cattle; enzyme-linked immunosorbent assay; epitopes; glycation; histamine; hypersensitivity; immunoglobulin E; lactalbumin; mass spectrometry; phosphorylation;     Show all 13 Subjects
Abstract:
... Bovine α-lactalbumin (α-Lac) allergy is a common health problem. This study assesses the allergenic reactivity and the structural properties of α-Lac after protein modification (glycation, phosphorylation and acetylation) by ELISA, cells experiment and high-resolution mass spectrometry. Three modified methods significantly reduced the IgE/IgG-binding capacity, and the release of histamine and inte ...
DOI:
10.1016/j.foodchem.2019.125853

13. Combination of PEG-decorated black phosphorus nanosheets and immunoadjuvant for photoimmunotherapy of melanoma

Author:
Wan, Shiyu; Zhang, Boya; Li, Sai; He, Bin; Pu, Yuji
Source:
Journal of materials chemistry B 2020 v.8 no.14 pp. 2805-2813
ISSN:
2050-7518
Subject:
interleukin-6,   etc   ; antigens; electrostatic interactions; immune response; interleukin-12; melanoma; mice; nanosheets; phosphorus; photothermotherapy; polyethylene glycol; tumor necrosis factor-alpha;     Show all 12 Subjects
Abstract:
... Photoimmunotherapy, which combines local photothermal therapy (PTT) with immunological stimulation, is a promising modality for cancer treatment. Herein, we have reported a photothermal-immunotherapy of melanoma using pegylated black phosphorus nanosheets (BP-PEG NSs) and imiquimod (R837) as the photothermal conversion agent and the immunoadjuvant, respectively. The photothermal stability of BP NS ...
DOI:
10.1039/d0tb00434k

14. Protective Effects of Polysaccharide Extracted from Portulacae oleracea L. on Colitis Induced by Dextran Sulfate Sodium

Author:
Wang, Zheng; Liang, Yanni; Zhang, Dongbo; Wu, Xue; Yu, Jingao; Zhang, Zhen; Li, Yi; Sun, Chen; Tang, Zhishu; Liu, Li
Source:
Journal of medicinal food 2020 v.23 no.2 pp. 125-131
ISSN:
1557-7600
Subject:
interleukin-6,   etc   ; catalytic activity; colitis; colon; dextran sulfate; histopathology; phosphorylation; protective effect; protein content; protein synthesis; proteins; staining; therapeutics;     Show all 13 Subjects
Abstract:
... Polysaccharide from Ma-chi-xian (Portulacae oleracea L., POLP) was prepared and the therapeutic effect on dextran sodium sulfate-induced colitis mice was investigated in this study. The results of clinical activity score and H&E staining confirmed the therapeutic effect of POLP. POLP could diminished the symptoms of colitis and improve colon histopathological structure of the colitis mice. The exp ...
DOI:
10.1089/jmf.2019.4414

15. Correction: Isoleucine attenuates infection induced by E. coli challenge through the modulation of intestinal endogenous antimicrobial peptide expression and the inhibition of the increase in plasma endotoxin and IL-6 in weaned pigs

Author:
Ren, Man; Cai, Shuang; Zhou, Tong; Zhang, Shihai; Li, Shenghe; Jin, Erhui; Che, Chuanyan; Zeng, Xiangfang; Zhang, Tao; Qiao, Shiyan
Source:
Food & function 2019 v.10 no.6 pp. 3799
ISSN:
2042-650X
Subject:
interleukin-6,   etc   ; Escherichia coli; antimicrobial peptides; endotoxins; intestines; isoleucine; swine;     Show all 7 Subjects
Abstract:
... Correction for ‘Isoleucine attenuates infection induced by E. coli challenge through the modulation of intestinal endogenous antimicrobial peptide expression and the inhibition of the increase in plasma endotoxin and IL-6 in weaned pigs’ by Man Ren et al., Food Funct., 2019, DOI: 10.1039/c9fo00218a. ...
DOI:
10.1039/c9fo90028d

16. Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways

Author:
Han, Ying-Hao; Chen, Dong-Qin; Jin, Mei-Hua; Jin, Ying-Hua; Li, Jing; Shen, Gui-Nan; Li, Wei-Long; Gong, Yi-Xi; Mao, Ying-Ying; Xie, Dan-Ping; Lee, Dong-Seok; Yu, Li-Yun; Kim, Sun-Uk; Kim, Ji-Su; Kwon, Taeho; Cui, Yu-Dong; Sun, Hu-Nan
Source:
Applied biological chemistry 2020 v.63 no.1 pp. 21
ISSN:
2468-0834
Subject:
interleukin-6,   etc   ; anti-inflammatory activity; inflammation; macrophage activation; macrophages; mitogen-activated protein kinase; nitric oxide; phagocytosis; reactive oxygen species; signal transduction; therapeutics; tumor necrosis factor-alpha;     Show all 12 Subjects
Abstract:
... Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α p ...
DOI:
10.1186/s13765-020-00504-2

17. Effects of resistant starch interventions on circulating inflammatory biomarkers: a systematic review and meta-analysis of randomized controlled trials

Author:
Vahdat, Mahsa; Hosseini, Seyed Ahmad; Khalatbari Mohseni, Golsa; Heshmati, Javad; Rahimlou, Mehran
Source:
Nutrition journal 2020 v.19 no.1 pp. 33
ISSN:
1475-2891
Subject:
interleukin-6,   etc   ; C-reactive protein; biomarkers; blood serum; databases; meta-analysis; randomized clinical trials; resistant starch; sample size; screening; systematic review; tumor necrosis factor-alpha;     Show all 12 Subjects
Abstract:
... PURPOSE: This study aimed to summarize earlier studies on the effects of RS consumption on the serum levels of inflammatory biomarkers. METHODS: A comprehensive search was done in the electronic databases that published from 1988 up to May 2019. Two reviewers independently performed screening, data extraction, and risk-of-bias assessment. We used from the effect size, as estimated by the mean diff ...
DOI:
10.1186/s12937-020-00548-6
PubMed:
32293469
PubMed Central:
PMC7158011

18. The changes of inflammatory mediators and vasoactive substances in dairy cows’ plasma with pasture-associated laminitis

Author:
Zhang, Xianhao; Ding, Jiafeng; Li, Yuepeng; Song, Qiaozhi; Li, Shuaichen; Hayat, Muhammad Abid; Zhang, Jiantao; Wang, Hongbin
Source:
BMC veterinary research 2020 v.16 no.1 pp. 119
ISSN:
1746-6148
Subject:
interleukin-6,   etc   ; animal welfare; blood plasma; dairy cows; dairy farming; hooves; inducible nitric oxide synthase; inflammation; jugular vein; laminitis; mastitis; pastures; tumor necrosis factor-alpha; veterinarians; China;     Show all 15 Subjects
Abstract:
... BACKGROUND: Hoof disease is one of the three major diseases that often occur in dairy cows. The impact of this disease on dairy farming is second only to mastitis. Laminitis is a diffuse, aseptic, serous, non-purulent inflammation of the dermal papillae and vascular layers of the cow’s hoof wall. In the pasture, laminitis occurs mostly in the laminae, that is, inside the hoof shell. No lesions can ...
DOI:
10.1186/s12917-020-02319-1
PubMed:
32326962
PubMed Central:
PMC7178631

19. Structural characterization and immunostimulatory activity of polysaccharides from Pyrus sinkiangensis Yu

Author:
Zhou, Kai; Taoerdahong, Hailiqian; Bai, Jie; Bakasi, Ayixiaguli; Wang, Xiaojing; Dong, Caixia
Source:
International journal of biological macromolecules 2020 v.157 pp. 444-451
ISSN:
0141-8130
Subject:
interleukin-6,   etc   ; Pyrus; arabinans; cell viability; gel chromatography; glucose; immunostimulants; ion exchange; macrophages; methylation; nitric oxide; nuclear magnetic resonance spectroscopy; pulp; secretion; tumor necrosis factor-alpha; xyloglucans; xylose;     Show all 17 Subjects
Abstract:
... Two neutral polysaccharides (PSNP-1, 104.7 kDa; PSNP-2, 24.5 kDa) were isolated from the pulp of Pyrus sinkiangensis Yu. by using the combined techniques of ion-exchange and gel permeation chromatography. According to the IR, NMR spectra, monosaccharide composition, and methylation analyses, PSNP-1 was mainly composed of glucose and xylose residues, which form a typical xyloglucan. PSNP-2 containe ...
DOI:
10.1016/j.ijbiomac.2020.04.146

20. Highly sensitive impedimetric immunosensor for determination of interleukin 6 as a cancer biomarker by using conjugated polymer containing epoxy side groups modified disposable ITO electrode

Author:
Aydın, Elif Burcu
Source:
Talanta 2020 v.215 pp. 120909
ISSN:
0039-9140
Subject:
interleukin-6,   etc   ; antigens; biomarkers; blood serum; calibration; detection limit; dielectric spectroscopy; early diagnosis; electrodes; epoxides; humans; immunosensors; indium tin oxide; phosphates; polymers; prostatic neoplasms; pyrroles; storage quality; voltammetry;     Show all 19 Subjects
Abstract:
... A novel impedimetric immunosensor based on a conjugated polypyrrole polymer containing epoxy active side groups (PPCE) modified indium tin oxide (ITO) electrode was developed for detection of interleukin 6 (IL 6), a prostate cancer biomarker. IL 6 receptor was used as a biorecognition molecule and successfully immobilized by covalent linkage on the modified ITO electrode. Pyrrole monomer containin ...
DOI:
10.1016/j.talanta.2020.120909