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1. Association of polymorphisms at −174 in IL-6, and −308 and −238 in TNF-α, in the development of tuberculosis and type 2 diabetes mellitus in the Mexican population

Author:
Lara-Gómez, Ruth Elizabeth; Moreno-Cortes, María Luisa; Muñiz-Salazar, Raquel; Zenteno-Cuevas, Roberto
Source:
Gene 2019 v.702 pp. 1-7
ISSN:
0378-1119
Subject:
interleukin-6,   etc   ; comorbidity; cross-sectional studies; genotype; risk factors; tuberculosis; tumor necrosis factor-alpha;     Show all 7 Subjects
Abstract:
... Polymorphisms at −176 in IL-6, and −238 and −308 in TNF-α have been described as risk factors for developing tuberculosis (TB) and type 2 diabetes mellitus (T2DM). However, it is not known how these changes influence the development of TB-T2DM comorbidity. The objective of this work was therefore to analyze the impact of these polymorphisms in the Mexican population.This is a cross-sectional study ...
DOI:
10.1016/j.gene.2019.03.050

2. Combining single molecule counting with bead-based multiplexing to quantify biological inflammation time course following skeletal muscle injury

Author:
Tanner, Elizabeth A.; Gary, Melody A.; Davis, Asheal A.; McFarlin, Brian K.
Source:
Methods 2019 v.158 pp. 77-80
ISSN:
1046-2023
Subject:
interleukin-6,   etc   ; exercise; inflammation; interleukin-1beta; muscles; skeletal muscle; tumor necrosis factor-alpha;     Show all 7 Subjects
Abstract:
... Bead-based analysis methods allow for the exploration of a variety of complex biological processes. In particular, these techniques can be applied to better understand how peripheral muscle injury contributes to systemic inflammation. Understanding how these two processes affect one another can give additional insight concerning how changes in inflammation effect readiness to perform in exercise a ...
DOI:
10.1016/j.ymeth.2018.11.013

3. Ru(NH₃)₆³⁺/Ru(NH₃)₆²⁺-Mediated Redox Cycling: Toward Enhanced Triple Signal Amplification for Photoelectrochemical Immunoassay

Author:
Wang, Bing; Xu, Yi-Tong; Lv, Jing-Lu; Xue, Tie-Ying; Ren, Shu-Wei; Cao, Jun-Tao; Liu, Yan-Ming; Zhao, Wei-Wei
Source:
Analytical chemistry 2019 v.91 no.6 pp. 3768-3772
ISSN:
1520-6882
Subject:
interleukin-6,   etc   ; alkaline phosphatase; aminophenols; ammonia; immunoassays; lighting; oxidation; phosphates; phosphine; reducing agents;     Show all 10 Subjects
Abstract:
... Herein we report an effective Ru(NH₃)₆³⁺/Ru(NH₃)₆²⁺-mediated photoelectrochemical-chemical-chemical (PECCC) redox cycling amplification (RCA) strategy toward enhanced triple signal amplification for advanced split-type PEC immunoassay application. Specifically, alkaline phosphatase (ALP) label was confined via a sandwich immunorecognition to convert 4-aminophenyl phosphate to the signal reporter 4 ...
DOI:
10.1021/acs.analchem.8b05129

4. 3D type I collagen environment leads up to a reassessment of the classification of human macrophage polarizations

Author:
Court, Magali; Malier, Marie; Millet, Arnaud
Source:
Biomaterials 2019 v.208 pp. 98-109
ISSN:
0142-9612
Subject:
interleukin-6,   etc   ; CD18 antigen; collagen; homeostasis; humans; immunomodulation; inflammasomes; interleukin-1beta; macrophages; neoplasms; phenotypic plasticity; phosphorylation; polymerization; rats; secretion;     Show all 15 Subjects
Abstract:
... Macrophages have multiple roles in development, tissue homeostasis and repair and present a high degree of phenotypic plasticity embodied in the concept of polarization. One goal of macrophage biology field is to characterize these polarizations at the molecular level. To achieve this task, it is necessary to integrate how physical environment signals are interpreted by macrophages under immune st ...
DOI:
10.1016/j.biomaterials.2019.04.018

5. PEDV nsp16 negatively regulates innate immunity to promote viral proliferation

Author:
Shi, Peidian; Su, Yanxin; Li, Ruiqiao; Liang, Zhixuan; Dong, Shuren; Huang, Jinhai
Source:
Virus research 2019 v.265 pp. 57-66
ISSN:
0168-1702
Subject:
interleukin-6,   etc   ; Porcine epidemic diarrhea virus; diarrhea; enzymes; gene overexpression; innate immunity; interferon-beta; messenger RNA; pathogenesis; swine; viruses;     Show all 11 Subjects
Abstract:
... Type-I IFNs (IFN-I) provide a key mediator of innate antiviral response during virus proliferation. Porcine epidemic diarrhea virus (PEDV), which causes diarrhea in swine of all ages, is a worldwide-distributed alphacoronavirus with economic importance. Here, we screened PEDV RNA modification enzymes involved in regulating antiviral response. Whereas the PEDV nsp13 barely regulates type I IFN, inf ...
DOI:
10.1016/j.virusres.2019.03.005

6. Taurine reduces hyperactive behavior in SHR rats through upregulating the proportion of CD4+CD25+Foxp3+ regulatory T cells

Author:
Chen, Vincent Chin-Hung; Chiu, Chun-Ching; Weng, Jun-Cheng; Chen, Li-Jeng; Siow, Jing Yi; Hsu, Tsai-Ching; Tzang, Bor-Show
Source:
Journal of functional foods 2019 v.56 pp. 312-320
ISSN:
1756-4646
Subject:
interleukin-6,   etc   ; T-lymphocytes; adults; behavior disorders; children; dopamine; galectins; interleukin-10; interleukin-2; locomotion; rats; systolic blood pressure; taurine;     Show all 13 Subjects
Abstract:
... Attention deficit hyperactivity disorder (ADHD) is a most common mental illness in both children and adults. Our recent studies revealed that high-dose taurine improves hyperactivity in SHR rats by reducing mALFF signal and striatal dopamine uptake. This study further revealed the association between immune factors and hyperactivity in SHR rats fed with high-dose taurine. A positive correlation wa ...
DOI:
10.1016/j.jff.2019.03.032

7. Sensitive Raman detection of human recombinant interleukin-6 mediated by DCDR/GERS hybrid platforms

Author:
de la O-Cuevas, Emmanuel; Badillo-Ramírez, Isidro; Islas, Selene R.; Araujo-Andrade, C.; Saniger, José M.
Source:
RSC advances 2019 v.9 no.22 pp. 12269-12275
ISSN:
2046-2069
Subject:
interleukin-6,   etc   ; Raman spectroscopy; biomarkers; clinical examination; detection limit; droplets; graphene oxide; humans; immune system; inflammation; silicon;     Show all 11 Subjects
Abstract:
... Recombinant human interleukin-6 (IL-6) is a key cytokine that plays an important role in the immune system and inflammatory response, explaining why any modification of its concentration in biological fluids is considered a signal of a pathological condition. Therefore, it is important to develop alternative, highly sensitive and reliable analytical methodologies to detect and identify this analyt ...
DOI:
10.1039/c9ra01396b

8. Epistasis between ADIPOQ rs1501299 and PON1 rs662 polymorphisms is potentially associated with the development of knee osteoarthritis

Author:
Fernández-Torres, Javier; Martínez-Nava, Gabriela Angélica; Zamudio-Cuevas, Yessica; Martínez-Flores, Karina; Espinosa-Morales, Rolando
Source:
Molecular biology reports 2019 v.46 no.2 pp. 2049-2058
ISSN:
0301-4851
Subject:
interleukin-6,   etc   ; cartilage; entropy; epistasis; genes; genotype; genotyping; osteoarthritis; overweight; oxidative stress; pathogenesis; patients; risk; single nucleotide polymorphism;     Show all 14 Subjects
Abstract:
... Overweight produces oxidative stress (OS) on the articular cartilage, with the subsequent risk of developing knee osteoarthritis (OA). Associations between genetic polymorphisms related to OS and OA have been reported, but it is currently unknown whether there exist interactions among them that affect OA development. To identify and evaluate interactions between multiple SNPs related to OS in Mexi ...
DOI:
10.1007/s11033-019-04654-5

9. Expression of interleukins 6 and 10 and population of inflammatory cells in the equine endometrium: diagnostic implications

Author:
de Holanda, Aline Gomes Buarque; da Silva Leite, Juliana; Consalter, Angélica; da Silva, Kassia Valéria Gomes Coelho; dos Santos Batista, Barbara Paula; Fonseca, Ana Beatriz Monteiro; Brandão, Felipe Zandonadi; Ferreira, Ana Maria Reis
Source:
Molecular biology reports 2019 v.46 no.2 pp. 2485-2491
ISSN:
0301-4851
Subject:
interleukin-6,   etc   ; antibodies; artificial insemination; biopsy; diestrus; endometritis; endometrium; fibrosis; histopathology; immunohistochemistry; inflammation; interleukin-10; mares; ovulation;     Show all 14 Subjects
Abstract:
... Endometritis consists of an acute or chronic inflammatory process involving the endometrium and together with endometrosis constitute the main causes of infertility in mares. The aim of this study was to associate the histopathological findings with the immunohistochemical markers interleukins 6 (IL-6) and 10 (IL-10) to evaluate the inflammatory changes and progression of uterine tissue lesions of ...
DOI:
10.1007/s11033-018-04579-5

10. Enhanced Immunoassay Using a Rotating Paper Platform for Quantitative Determination of Low Abundance Protein Biomarkers

Author:
Sedighi, Abootaleb; Krull, Ulrich. J.
Source:
Analytical chemistry 2019 v.91 no.8 pp. 5371-5379
ISSN:
1520-6882
Subject:
interleukin-6,   etc   ; bioassays; biomarkers; blood serum; colorimetry; detection limit; immunoassays; nanoparticles; oligonucleotides; paper; patients; proteins; quantitative analysis; therapeutics;     Show all 14 Subjects
Abstract:
... The changing concentrations of circulating protein biomarkers have been correlated with a variety of diseases. Quantitative bioassays capable of sensitive and specific determination of protein biomarkers at low levels can be essential for therapeutic treatments that can improve outcomes for patients. Herein, we describe the investigation of a rotating paper device (RPD) for quantitative determinat ...
DOI:
10.1021/acs.analchem.9b00502

11. MiR-3926 inhibits synovial fibroblasts proliferation and inflammatory cytokines secretion through targeting toll like receptor 5

Author:
Fu, Di; Xiao, Chuyin; Xie, Yingying; Gao, Jianquan; Ye, Shanhui
Source:
Gene 2019 v.687 pp. 200-206
ISSN:
0378-1119
Subject:
interleukin-6,   etc   ; Toll-like receptor 5; bioactive properties; fibroblasts; interleukin-1beta; pathogenesis; rheumatoid arthritis; secretion; tumor necrosis factor-alpha;     Show all 9 Subjects
Abstract:
... Rheumatoid arthritis synovial fibroblasts (RASFs) play a key role in the pathogenesis of rheumatoid arthritis (RA). This study was aimed to investigate the effects of miR-3926 on the biological activities of RASFs. The results showed that miR-3926 was significantly down-regulated in RASFs and RA synovial tissue. Overexpression of miR-3926 significantly inhibited RASFs proliferation and decreased t ...
DOI:
10.1016/j.gene.2018.11.014

12. Fecal bacteria from ulcerative colitis patients downregulate Tim-3-mediated inhibitory effects on monocytes in vitro

Author:
Wang, Shaoxuan; Liu, Yanyan; Yuan, Xuemin; Yao, Li; Yang, Shaofeng; Ma, Ran
Source:
Microbial pathogenesis 2019 v.128 pp. 147-152
ISSN:
0882-4010
Subject:
interleukin-6,   etc   ; colitis; fecal bacteria; galectins; ligands; macrophage activation; macrophages; monocytes; patients; secretion; tumor necrosis factor-alpha;     Show all 11 Subjects
Abstract:
... Tim-3 is highly expressed on monocytes and macrophages. Blocking Tim-3 was shown to promote macrophage activation. We previously showed that fecal bacteria from patients with active ulcerative colitis (UC) presented significantly higher capacity to stimulate monocyte activation, resulting in higher expression of MHC molecules, costimulatory molecules, and proinflammatory cytokines, but the underly ...
DOI:
10.1016/j.micpath.2018.12.043

13. Development of a multiplexed giant magnetoresistive biosensor array prototype to quantify ovarian cancer biomarkers

Author:
Klein, Todd; Wang, Wei; Yu, Lina; Wu, Kai; Boylan, Kristin L.M.; Vogel, Rachel Isaksson; Skubitz, Amy P.N.; Wang, Jian-Ping
Source:
Biosensors & bioelectronics 2019 v.126 pp. 301-307
ISSN:
0956-5663
Subject:
interleukin-6,   etc   ; animal ovaries; antigens; biomarkers; biosensors; detection limit; epididymis; human diseases; humans; mobile telephones; ovarian neoplasms; prototypes; user interface;     Show all 13 Subjects
Abstract:
... In this work, we developed benchtop and handheld Giant Magnetoresistive (GMR) biosensing systems that serve as platforms for detecting a wide variety of protein biomarkers for human diseases. System development included spintronic and nanomagnetic materials, biomolecular chemistry, electronic circuitry, analog and digital signal processing, firmware programming, user interface programming on both ...
DOI:
10.1016/j.bios.2018.10.046

14. Psychological responses, muscle damage, inflammation, and delayed onset muscle soreness to high-intensity interval and moderate-intensity continuous exercise in overweight men

Author:
Farias-Junior, Luiz Fernando; Browne, Rodrigo Alberto Vieira; Freire, Yuri Alberto; Oliveira-Dantas, Filipe Fernandes; Lemos, Telma Maria Araújo Moura; Galvão-Coelho, Nicole Leite; Hardcastle, Sarah J.; Okano, Alexandre Hideki; Aoki, Marcelo Saldanha; Costa, Eduardo Caldas
Source:
Physiology & behavior 2019 v.199 pp. 200-209
ISSN:
0031-9384
Subject:
interleukin-6,   etc   ; creatine kinase; exercise; inflammation; lactate dehydrogenase; men; muscles; overweight; physiological response; self-efficacy; tumor necrosis factor-alpha;     Show all 11 Subjects
Abstract:
... We compared in-task affect to HIIE and MICE, and its relationship with time spent at different metabolic domains, perceived exertion (RPE), self-efficacy, enjoyment, and future intention of exercise in overweight inactive men. Muscle damage and soreness, and inflammation were assessed post-exercise. Fifteen participants (28.9 ± 5.0 yr; 29.2 ± 3.8 kg/m2) completed a HIIE (10 × 1 min at 100% Vmax, 1 ...
DOI:
10.1016/j.physbeh.2018.11.028

15. Sonic hedgehog drives layered double hydroxides-induced acute inflammatory landscape

Author:
da Silva Feltran, Geórgia; da Costa Fernandes, Célio Junior; Rodrigues Ferreira, Marcel; Kang, Ha Ram; de Carvalho Bovolato, Ana Lívia; de Assis Golim, Márjorie; Deffune, Elenice; Koh, Ivan Hong Jun; Constantino, Vera Regina Leopoldo; Zambuzzi, Willian F.
Source:
Colloids and surfaces 2019 v.174 pp. 467-475
ISSN:
0927-7765
Subject:
interleukin-6,   etc   ; colloids; cyclopamine; genes; health services; humans; hydroxides; inflammasomes; interleukin-10; landscapes; nanomaterials; osteoblasts; tumor necrosis factor-alpha;     Show all 13 Subjects
Abstract:
... Although layered double hydroxides (LDH) have been listed as promising nanomaterials in human healthcare, very little has been achieved on osteoblast inflammatory signaling. Thus, osteoblasts were challenged with two LDHs (Mg2Al-Cl and Zn2Al-Cl, at 0.002 mg/mL) up to 24 h, establishing an acute inflammatory mechanism, as well as identifying whether Sonic hedgehog (Shh) signaling has an influence. ...
DOI:
10.1016/j.colsurfb.2018.11.051

16. Effects of 12-wk Lactobacillus plantarum OLL2712 treatment on glucose metabolism and chronic inflammation in prediabetic individuals: A single-arm pilot study

Author:
Toshimitsu, Takayuki; Gotou, Ayako; Furuichi, Keisuke; Hachimura, Satoshi; Asami, Yukio
Source:
Nutrition 2019 v.58 pp. 175-180
ISSN:
0899-9007
Subject:
interleukin-6,   etc   ; Lactobacillus plantarum; animal models; beverages; blood glucose; blood serum; diabetes; glucose; hyperglycemia; inflammation; insulin resistance; metabolism; obesity;     Show all 13 Subjects
Abstract:
... Previously, we demonstrated that the administration of heat-killed OLL2712 cells suppressed chronic inflammation and improved hyperglycemia in a mouse model of obesity and diabetes. The aim of this study was to preliminarily examine the effect of OLL2712 supplementation on glucose metabolism and chronic inflammation in prediabetic subjects.This study was a prospective, 12-wk, single-arm, open tria ...
DOI:
10.1016/j.nut.2018.07.116

17. Vitamin E δ-tocotrienol inhibits TNF-α-stimulated NF-κB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides

Author:
Yang, Chao; Jiang, Qing
Source:
The Journal of nutritional biochemistry 2019 v.64 pp. 101-109
ISSN:
0955-2863
Subject:
interleukin-6,   etc   ; cell viability; ceramides; delta-tocotrienol; enzymes; inflammation; macrophages; phosphorylation; therapeutics; transcription factor NF-kappa B; transforming growth factors;     Show all 11 Subjects
Abstract:
... Nuclear factor-κB (NF-κB) regulates inflammation and cell survival, and is considered a potential target for anti-inflammatory and anti-cancer therapy. δ-Tocotrienol (δTE), a vitamin E form, has been shown to inhibit NF-κB, but the mechanism underlying this action is not clear. In the present study, we show that δTE inhibited TNF-α-induced activation of NF-κB and LPS-stimulated IL-6 in a dose- and ...
DOI:
10.1016/j.jnutbio.2018.10.013

18. PE17 protein from Mycobacterium tuberculosis enhances Mycobacterium smegmatis survival in macrophages and pathogenicity in mice

Author:
Li, Zhe; Liu, Hongxiu; Li, Huafang; Dang, Guanghui; Cui, Ziyin; Song, Ningning; Wang, Quankai; Liu, Siguo; Chen, Liping
Source:
Microbial pathogenesis 2019 v.126 pp. 63-73
ISSN:
0882-4010
Subject:
interleukin-6,   etc   ; Mycobacterium smegmatis; Mycobacterium tuberculosis; bacteria; hosts; interferon-gamma; interleukin-12; interleukin-1beta; macrophages; mice; models; necrosis; pathogenicity; secretion;     Show all 14 Subjects
Abstract:
... The capacity of Mycobacterium tuberculosis to survive and cause disease is strongly correlated with its ability to escape multiple defense strategies in hosts. In particular, M. tuberculosis has the remarkable capacity to survive within the hostile environment of macrophages. Here, we found that the PE17 (Rv1646) protein promoted intracellular survival of M. smegmatis in peritoneal macrophages fro ...
DOI:
10.1016/j.micpath.2018.10.030

19. Assessing the usefulness of acute physiological responses following resistance exercise: sensitivity, magnitude of change, and time course of measures

Author:
Jackman, Joshua S.; Bell, Phillip G.; Gill, Simone; van Someren, Ken; Davison, Gareth W.; Cockburn, Emma
Source:
Applied physiology, nutrition and metabolism 2019 v.44 no.3 pp. 309-319
ISSN:
1715-5320
Subject:
interleukin-6,   etc   ; C-reactive protein; athletes; creatine kinase; gelatinase B; males; muscles; physiological response; signal-to-noise ratio; strength training;     Show all 10 Subjects
Abstract:
... A variety of strategies exist to modulate the acute physiological responses following resistance exercise aimed at enhancing recovery and/or adaptation processes. To assess the true impact of these strategies, it is important to know the ability of different measures to detect meaningful change. We investigated the sensitivity of measures used to quantify acute physiological responses to resistanc ...
DOI:
10.1139/apnm-2018-0200

20. Recovery following Rugby Union matches: effects of cold water immersion on markers of fatigue and damage

Author:
Nunes, Renan Felipe Hartmann; Duffield, Rob; Nakamura, Fábio Yuzo; Bezerra, Ewertton de Souza; Sakugawa, Raphael Luiz; Loturco, Irineu; Bobinski, Franciane; Martins, Daniel Fernandes; Guglielmo, Luiz Guilherme Antonacci
Source:
Applied physiology, nutrition and metabolism 2019 v.44 no.5 pp. 546-556
ISSN:
1715-5320
Subject:
interleukin-6,   etc   ; athletes; cold; global positioning systems; inflammation; males; muscle fatigue; muscles; tumor necrosis factor-alpha; water;     Show all 10 Subjects
Abstract:
... We investigated the effect of postmatch cold-water immersion (CWI) on markers of muscle damage, neuromuscular fatigue, and perceptual responses within 72 h after a rugby match. Twenty-two professional male rugby players were randomized into CWI (10 °C/10 min; n = 11) or control (CON: 30 min seated; n = 11) groups. Activity profile from Global Positioning Satellite systems and postmatch rating of p ...
DOI:
10.1139/apnm-2018-0542