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1. Development of a multiplexed giant magnetoresistive biosensor array prototype to quantify ovarian cancer biomarkers

Author:
Klein, Todd; Wang, Wei; Yu, Lina; Wu, Kai; Boylan, Kristin L.M.; Vogel, Rachel Isaksson; Skubitz, Amy P.N.; Wang, Jian-Ping
Source:
Biosensors & bioelectronics 2019 v.126 pp. 301-307
ISSN:
0956-5663
Subject:
interleukin-6,   etc   ; animal ovaries; antigens; biomarkers; biosensors; detection limit; epididymis; human diseases; humans; mobile telephones; ovarian neoplasms; prototypes; user interface;     Show all 13 Subjects
Abstract:
... In this work, we developed benchtop and handheld Giant Magnetoresistive (GMR) biosensing systems that serve as platforms for detecting a wide variety of protein biomarkers for human diseases. System development included spintronic and nanomagnetic materials, biomolecular chemistry, electronic circuitry, analog and digital signal processing, firmware programming, user interface programming on both ...
DOI:
10.1016/j.bios.2018.10.046

2. Psychological responses, muscle damage, inflammation, and delayed onset muscle soreness to high-intensity interval and moderate-intensity continuous exercise in overweight men

Author:
Farias-Junior, Luiz Fernando; Browne, Rodrigo Alberto Vieira; Freire, Yuri Alberto; Oliveira-Dantas, Filipe Fernandes; Lemos, Telma Maria Araújo Moura; Galvão-Coelho, Nicole Leite; Hardcastle, Sarah J.; Okano, Alexandre Hideki; Aoki, Marcelo Saldanha; Costa, Eduardo Caldas
Source:
Physiology & behavior 2019 v.199 pp. 200-209
ISSN:
0031-9384
Subject:
interleukin-6,   etc   ; creatine kinase; exercise; inflammation; lactate dehydrogenase; men; muscles; overweight; physiological response; self-efficacy; tumor necrosis factor-alpha;     Show all 11 Subjects
Abstract:
... We compared in-task affect to HIIE and MICE, and its relationship with time spent at different metabolic domains, perceived exertion (RPE), self-efficacy, enjoyment, and future intention of exercise in overweight inactive men. Muscle damage and soreness, and inflammation were assessed post-exercise. Fifteen participants (28.9 ± 5.0 yr; 29.2 ± 3.8 kg/m2) completed a HIIE (10 × 1 min at 100% Vmax, 1 ...
DOI:
10.1016/j.physbeh.2018.11.028

3. Sonic hedgehog drives layered double hydroxides-induced acute inflammatory landscape

Author:
da Silva Feltran, Geórgia; da Costa Fernandes, Célio Junior; Rodrigues Ferreira, Marcel; Kang, Ha Ram; de Carvalho Bovolato, Ana Lívia; de Assis Golim, Márjorie; Deffune, Elenice; Koh, Ivan Hong Jun; Constantino, Vera Regina Leopoldo; Zambuzzi, Willian F.
Source:
Colloids and surfaces 2019 v.174 pp. 467-475
ISSN:
0927-7765
Subject:
interleukin-6,   etc   ; colloids; cyclopamine; genes; health services; humans; hydroxides; inflammasomes; interleukin-10; landscapes; nanomaterials; osteoblasts; tumor necrosis factor-alpha;     Show all 13 Subjects
Abstract:
... Although layered double hydroxides (LDH) have been listed as promising nanomaterials in human healthcare, very little has been achieved on osteoblast inflammatory signaling. Thus, osteoblasts were challenged with two LDHs (Mg2Al-Cl and Zn2Al-Cl, at 0.002 mg/mL) up to 24 h, establishing an acute inflammatory mechanism, as well as identifying whether Sonic hedgehog (Shh) signaling has an influence. ...
DOI:
10.1016/j.colsurfb.2018.11.051

4. Effects of 12-wk Lactobacillus plantarum OLL2712 treatment on glucose metabolism and chronic inflammation in prediabetic individuals: A single-arm pilot study

Author:
Toshimitsu, Takayuki; Gotou, Ayako; Furuichi, Keisuke; Hachimura, Satoshi; Asami, Yukio
Source:
Nutrition 2019 v.58 pp. 175-180
ISSN:
0899-9007
Subject:
interleukin-6,   etc   ; Lactobacillus plantarum; animal models; beverages; blood glucose; blood serum; diabetes; glucose; hyperglycemia; inflammation; insulin resistance; metabolism; obesity;     Show all 13 Subjects
Abstract:
... Previously, we demonstrated that the administration of heat-killed OLL2712 cells suppressed chronic inflammation and improved hyperglycemia in a mouse model of obesity and diabetes. The aim of this study was to preliminarily examine the effect of OLL2712 supplementation on glucose metabolism and chronic inflammation in prediabetic subjects.This study was a prospective, 12-wk, single-arm, open tria ...
DOI:
10.1016/j.nut.2018.07.116

5. PE17 protein from Mycobacterium tuberculosis enhances Mycobacterium smegmatis survival in macrophages and pathogenicity in mice

Author:
Li, Zhe; Liu, Hongxiu; Li, Huafang; Dang, Guanghui; Cui, Ziyin; Song, Ningning; Wang, Quankai; Liu, Siguo; Chen, Liping
Source:
Microbial pathogenesis 2019 v.126 pp. 63-73
ISSN:
0882-4010
Subject:
interleukin-6,   etc   ; Mycobacterium smegmatis; Mycobacterium tuberculosis; bacteria; hosts; interferon-gamma; interleukin-12; interleukin-1beta; macrophages; mice; models; necrosis; pathogenicity; secretion;     Show all 14 Subjects
Abstract:
... The capacity of Mycobacterium tuberculosis to survive and cause disease is strongly correlated with its ability to escape multiple defense strategies in hosts. In particular, M. tuberculosis has the remarkable capacity to survive within the hostile environment of macrophages. Here, we found that the PE17 (Rv1646) protein promoted intracellular survival of M. smegmatis in peritoneal macrophages fro ...
DOI:
10.1016/j.micpath.2018.10.030

6. Synthesis and Structure–Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues

Author:
Wolleb, Helene; Ogawa, Seiji; Schneider, Michael; Shemet, Andrej; Muri, Jonathan; Kopf, Manfred; Carreira, Erick M.
Source:
Organic letters 2018 v.20 no.10 pp. 3014-3016
ISSN:
1523-7052
Subject:
interleukin-6,   etc   ; alcohols; chemical reactions; lactams; secretion; structure-activity relationships;     Show all 6 Subjects
Abstract:
... The lactone derivative of the epoxyisoprostane EC is a highly effective inhibitor of the secretion of the proinflammatory cytokine IL-6. Herein, a modular synthesis of analogues is described, allowing flexible variations of the cyclic side chain of the parent lactone. A structure–activity relationship study identified a lactam analogue that retains the high activity. Furthermore, the exocyclic all ...
DOI:
10.1021/acs.orglett.8b01042

7. TNF-α disrupts the integrity of the porcine respiratory epithelial barrier

Author:
Bercier, Philippe; Grenier, Daniel
Source:
Research in veterinary science 2019 v.124 pp. 13-17
ISSN:
0034-5288
Subject:
interleukin-6,   etc   ; dextran; electrical resistance; epithelial cells; epithelium; fluorescein; fluorescence microscopy; inflammation; interleukin-8; models; occludins; pathogens; secretion; swine; tight junctions; tumor necrosis factor-alpha;     Show all 16 Subjects
Abstract:
... The airway epithelium plays an important role in protecting the host against environmental microbial pathogens. The disruption of the epithelial barrier may lead to inflammation and invasion by bacterial pathogens. The aim of the present study was to determine whether TNF-α can damage the integrity of the epithelial barrier using a tracheal epithelial cell model. TNF-α (10 and 100 ng/mL) significa ...
DOI:
10.1016/j.rvsc.2019.01.029

8. Macranthol attenuates lipopolysaccharide-induced depressive-like behaviors by inhibiting neuroinflammation in prefrontal cortex

Author:
Weng, Lianjin; Dong, Shuqi; Wang, Shuangshuang; Yi, Litao; Geng, Di
Source:
Physiology & behavior 2019 v.204 pp. 33-40
ISSN:
0031-9384
Subject:
interleukin-6,   etc   ; Illicium dunnianum; blood serum; fluorescent antibody technique; interleukin-1beta; lignans; lipopolysaccharides; mice; prefrontal cortex; signal transduction; sucrose; swimming; tumor necrosis factor-alpha;     Show all 13 Subjects
Abstract:
... Macranthol is a lignans natural product isolated from Illicium dunnianum Tutch. Our previous studies have shown that BDNF dependent signaling pathway activation was involved in the antidepressant-like effects of macranthol. However, it is not clear whether neuro-inflammation suppression is involved in the effects of macranthol. Therefore, the aim of this present study was to determine whether macr ...
DOI:
10.1016/j.physbeh.2019.02.010

9. The effects of roux en y gastric bypass surgery on neurobehavioral symptom domains associated with severe obesity

Author:
Musselman, Dominique; Shenvi, Neeta; Manatunga, Amita; Miller, Andrew H.; Lin, Edward; Gletsu-Miller, Nana
Source:
Physiology & behavior 2019 v.204 pp. 86-92
ISSN:
0031-9384
Subject:
interleukin-6,   etc   ; C-reactive protein; adipose tissue; adiposity; anxiety; bariatric surgery; body mass index; cognition; inflammation; insulin resistance; leptin; mental depression; neurotoxicity; obesity; regression analysis; suicide; women;     Show all 17 Subjects
Abstract:
... Neurobehavioral symptoms and cognitive dysfunction related to mood disorders are present in individuals with severe obesity. We sought to determine acute improvements in these symptoms and relationships with adiposity, inflammation, and insulin sensitivity after roux-en-y gastric bypass (RYGB) surgery.The self-report Zung Depression Rating (ZDRS) and Neurotoxicity Rating (NRS) scales were administ ...
DOI:
10.1016/j.physbeh.2019.02.013

10. Effects of ω-3 supplementation on the nutritional status, immune, and inflammatory profiles of gastric cancer patients: A randomized controlled trial

Author:
Feijó, Patricia M.; Rodrigues, Viviane D.; Viana, Mônica S.; dos Santos, Mylena P.; Abdelhay, Eliana; Viola, João P.; de Pinho, Nivaldo B.; Martucci, Renata B.
Source:
Nutrition 2019 v.61 pp. 125-131
ISSN:
0899-9007
Subject:
interleukin-6,   etc   ; C-reactive protein; anthropometric measurements; bioelectrical impedance; body composition; longitudinal studies; men; muscles; nutritional status; patients; randomized clinical trials; stomach neoplasms; weight gain;     Show all 13 Subjects
Abstract:
... The aim of this study was to study the effect of ω-3 supplementation on the nutritional status and the immune and inflammatory profiles of patients with gastric cancer during antineoplastic pretreatment.This was a randomized, open, controlled longitudinal study with intervention in outpatient patients with gastric cancer. Sixty-eight patients were randomized into two groups and received either a f ...
DOI:
10.1016/j.nut.2018.11.014

11. Lactational exposure to environmentally relevant benzo(a)pyrene causes astrocytic activation and anxiety-like behavior in male mice

Author:
Yang, Chuanli; Han, Peiyu; Ruan, Fengkai; Zhou, Tengjian; Luo, Bing; Qiu, Yang; Lin, Yuchun; Lin, Zhongning; He, Chengyong
Source:
Chemosphere 2019 v.221 pp. 67-74
ISSN:
0045-6535
Subject:
interleukin-6,   etc   ; adolescence; antioxidant activity; antioxidant genes; astrocytes; benzo(a)pyrene; glutathione; hippocampus; males; mice; neurodevelopment; progeny; thioredoxins; tumor necrosis factor-alpha;     Show all 14 Subjects
Abstract:
... Previous studies have shown the adversely neurodevelopmental effects of exposure to benzo(a)pyrene (BaP) at early life stage. However, it is unclear the effects of lactational exposure to environmentally relevant BaP on anxiety-like behavior and the molecular mechanisms related. In this study, lactational exposure to 1 and 10 μg/kg bw BaP from postnatal day 3–21 caused anxiety-like behavior and al ...
DOI:
10.1016/j.chemosphere.2019.01.006

12. Levels of selected cytokines and acute–phase proteins in the serum of dairy cows with cystic ovarian disease and those in follicular and luteal phases of normal ovarian cycle

Author:
Brodzki, P.; Brodzki, A.; Krakowski, L.; Dąbrowski, R.; Szczubiał, M.; Bochniarz, M.
Source:
Research in veterinary science 2019 v.123 pp. 20-25
ISSN:
0034-5288
Subject:
interleukin-6,   etc   ; Holstein; acute phase proteins; amyloid; animal ovaries; blood serum; dairy cows; enzyme-linked immunosorbent assay; estradiol; haptoglobins; interleukin-10; ovarian cysts; progesterone; tumor necrosis factor-alpha;     Show all 14 Subjects
Abstract:
... The aim of the study was to evaluate the concentration of selected cytokines (tumor necrosis factor [TNFα], interleukin [IL]-6, IL-10) and acute-phase proteins (APPs; haptoglobin [Hp] and serum amyloid A [SAA]) in the serum of cows with follicular and luteal ovarian cysts and in those in the follicular and luteal phases of a physiological ovarian cycle. The study was conducted on 24 Holstein–Fries ...
DOI:
10.1016/j.rvsc.2018.12.007

13. Identification of an immunostimulatory polysaccharide in banana

Author:
Yang, Jiali; Tu, Jiaming; Liu, Huiling; Wen, Lingrong; Jiang, Yueming; Yang, Bao
Source:
Food chemistry 2019 v.277 pp. 46-53
ISSN:
0308-8146
Subject:
interleukin-6,   etc   ; T-lymphocytes; antibodies; bananas; cell proliferation; fruits; functional foods; hemolysins; immunoglobulin G; immunoglobulin M; immunostimulants; macrophages; polysaccharides; taste; tumor necrosis factor-alpha;     Show all 15 Subjects
Abstract:
... Banana is a fruit widely accepted by people over the world. Besides having delicious taste, it shows multiple health benefits. In this work, the major polysaccharide was isolated from banana and purified. It was identified to be α-(1 → 6)-d-glucan. The in vivo immunomodulatory activity assay indicated that α-(1 → 6)-d-glucan could improve the immune status by elevating T cell proliferation, phagoc ...
DOI:
10.1016/j.foodchem.2018.10.043

14. Peyer's patch-immunomodulating glucans from sugar cane enhance protective immunity through stimulation of the hemopoietic system

Author:
Sakai, Yusuke; Sato, Masakazu; Funami, Yusuke; Ishiyama, Aki; Hokari, Rei; Iwatsuki, Masato; Nagai, Takayuki; Otoguro, Kazuhiko; Yamada, Haruki; Ōmura, Satoshi; Kiyohara, Hiroaki
Source:
International journal of biological macromolecules 2019 v.124 pp. 505-514
ISSN:
0141-8130
Subject:
interleukin-6,   etc   ; Peyer's patches; Plasmodium; T-lymphocytes; antimalarials; blood flow; erythrocytes; glucans; immune response; interleukin-2; moieties; molasses; neutrophils; oral administration; sugarcane;     Show all 15 Subjects
Abstract:
... The aim of the present study was chemical clarification of in vitro Peyer's patch-immunomodulating polysaccharides in sugar cane molasses, and evaluation of in vivo modulating activity on immune function of T lymphocytes in Peyer's patches and on microenvironment of hemopoietic system. Five kinds of glucans, comprising of dextranase-sensitive and activity-related d-glucosyl moieties, were purified ...
DOI:
10.1016/j.ijbiomac.2018.11.180

15. Effects of cholecalciferol supplementation on inflammatory markers and muscle damage indices of soccer players after a simulated soccer match

Author:
Parsaie, Narges; Ghavamzadeh, Saeed; Cheraghi, Mahdi
Source:
Nutrition 2019 v.59 pp. 37-43
ISSN:
0899-9007
Subject:
interleukin-6,   etc   ; C-reactive protein; athletes; athletic performance; blood sampling; blood serum; cholecalciferol; creatine kinase; heart rate; inflammation; lactate dehydrogenase; muscles; placebos; sports;     Show all 14 Subjects
Abstract:
... Soccer-induced muscle damage and inflammation lead to a reduction in athletic performance. The aim of this study was to determine whether supplementation with cholecalciferol would reduce inflammation and muscle damage in soccer players after a simulated soccer match.Twenty-two soccer players (median age 27 y, interquartile range 5 y) were divided randomly into two groups, as follows: a cholecalci ...
DOI:
10.1016/j.nut.2018.06.028

16. Immunomodulatory effects of exopolysaccharides produced by Bacillus licheniformis and Leuconostoc mesenteroides isolated from Korean kimchi

Author:
Kook, Sun-Young; Lee, Yaelim; Jeong, Eui-Cheon; Kim, Seokjin
Source:
Journal of functional foods 2019 v.54 pp. 211-219
ISSN:
1756-4646
Subject:
interleukin-6,   etc   ; Bacillus licheniformis; Leuconostoc mesenteroides; arabinose; biofilm; cosmetics; dose response; exopolysaccharides; fucose; functional foods; galactose; glucose; immunomodulators; interleukin-10; kimchi; macrophages; mannose; mice; pH; pharmaceutical industry; secretion;     Show all 21 Subjects
Abstract:
... The immunomodulatory properties of exopolysaccharides (EPS), major components of bacterial biofilm, are not fully understood. Here, we examined the immunomodulatory potential of EPS derived from Bacillus licheniformis BioE-BL11 and Leuconostoc mesenteroides BioE-LMD18, isolated from Korean fermented kimchi. EPS from BioE-BL11 was composed of mannose (12.4%), galactose (1.82%), glucose (48.5%), fuc ...
DOI:
10.1016/j.jff.2019.01.003

17. Acyl-ghrelin mediated lipid retention and inflammation in obesity-related Type 2 diabetes

Author:
Churm, R.; Caplin, S.; Barry, J.; Davies, J.S.; Stephens, J.W.; Prior, S.L.
Source:
Molecular and cellular endocrinology 2019 v.481 pp. 8-13
ISSN:
0303-7207
Subject:
interleukin-6,   etc   ; antioxidants; blood glucose; gene expression regulation; genes; ghrelin; homeostasis; humans; hyperglycemia; inflammation; interleukin-10; lipids; macrophages; models; noninsulin-dependent diabetes mellitus; obesity; tumor necrosis factor-alpha;     Show all 17 Subjects
Abstract:
... Acyl-ghrelin has various peripheral effects including the potential role in mediating cellular lipid removal and macrophage polarization. Previous reports are contradictory as to how glycaemia and acyl-ghrelin mediates lipid retention and inflammation within individuals with Type 2 diabetes (T2D). Our aim was to explore acyl-ghrelin levels and ghrelin expression in relation to lipid and inflammato ...
DOI:
10.1016/j.mce.2018.11.004

18. Analysis of effectiveness of Iranian snake antivenom on Viper venom induced effects including analysis of immunologic biomarkers in the Echis carinatus sochureki envenomed victims

Author:
Monzavi, Seyed Mostafa; Afshari, Reza; Khoshdel, Ali Reza; Mahmoudi, Mahmoud; Salarian, Amir Ahmad; Samieimanesh, Farhad; Shirmast, Elham; Mihandoust, Azam
Source:
Toxicon 2019 v.158 pp. 38-46
ISSN:
0041-0101
Subject:
interleukin-6,   etc   ; Echis carinatus; antivenoms; biomarkers; complement; hemolysis; humans; inflammation; interleukin-1beta; interleukin-8; patients; prothrombin; snake bites; snakes; therapeutics; tumor necrosis factor-alpha; viper venoms;     Show all 17 Subjects
Abstract:
... Snakebite is an important toxicologic emergency with the potential of triggering local and systemic inflammation. Antivenom has remained the mainstay of treatment for snakebite envenomation. In this study we sought to investigate the effectiveness of Iranian antivenom in a series of 44 viper envenomed patients through analysis of changes in clinical severity and the levels of inflammatory markers. ...
DOI:
10.1016/j.toxicon.2018.11.293

19. Peripheral interleukin-6 levels and working memory in non-obese adults: A post-hoc analysis from the CALERIE study

Author:
Trevizol, Alisson P.; Brietzke, Elisa; Grigolon, Ruth Bartelli; Subramaniapillai, Mehala; McIntyre, Roger S.; Mansur, Rodrigo B.
Source:
Nutrition 2019 v.58 pp. 18-22
ISSN:
0899-9007
Subject:
interleukin-6,   etc   ; adults; alcohol drinking; data collection; energy intake; equations; long term effects; longitudinal studies; low calorie diet; memory; physical activity; sleep;     Show all 12 Subjects
Abstract:
... This analysis aimed to investigate the association among interleukin 6 (IL-6) levels, caloric intake, and working memory and to explore the potential mediators of these associations using the public dataset from the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) clinical trial.The CALERIE study was designed to evaluate the effects of 2 y of prolonged caloric r ...
DOI:
10.1016/j.nut.2018.06.010

20. Plantamajoside attenuates inflammatory response in LPS-stimulated human gingival fibroblasts by inhibiting PI3K/AKT signaling pathway

Author:
Liu, Fei; Huang, Xin; He, Jing-jun; Song, Ci; Peng, Ling; Chen, Ting; Wu, Bu-ling
Source:
Microbial pathogenesis 2019 v.127 pp. 208-211
ISSN:
0882-4010
Subject:
interleukin-6,   etc   ; Porphyromonas gingivalis; anti-inflammatory activity; bacteria; fibroblasts; humans; inflammation; interleukin-8; nitric oxide; periodontitis; phosphatidylinositol 3-kinase; phosphorylation; signal transduction; transcription factor NF-kappa B;     Show all 14 Subjects
Abstract:
... Periodontitis is an important inflammatory disease that often causes by periodontopathic bacteria. The present study, we tested the anti-inflammatory effects of plantamajoside on LPS-stimulated human gingival fibroblasts. Human gingival fibroblasts (HGFs) were stimulated with LPS from Porphyromonas gingivalis. Plantamajoside was administrated 1 h before LPS treatment. The results demonstrated that ...
DOI:
10.1016/j.micpath.2018.11.034