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1. Correction: Rational design of a peptide capture agent for CXCL8 based on a model of the CXCL8:CXCR1 complex

Author:
Helmer, Dorothea; Rink, Ina; Dalton, James A. R.; Brahm, Kevin; Jöst, Marina; Nargang, Tobias M.; Blum, Witali; Wadhwani, Parvesh; Brenner-Weiss, Gerald; Rapp, Bastian E.; Giraldo, Jesús; Schmitz, Katja
Source:
RSC advances 2018 v.8 no.30 pp. 16800-16801
ISSN:
2046-2069
Subject:
interleukin-8,   etc   ; models; synthesis;     Show all 3 Subjects
Abstract:
... Correction for ‘Rational design of a peptide capture agent for CXCL8 based on a model of the CXCL8:CXCR1 complex’ by Dorothea Helmer et al., RSC Adv., 2015, 5, 25657–25668. ...
DOI:
10.1039/c8ra90035c

2. IL- 6 and IL-8 are involved in JMJD2A-regulated malignancy of ovarian cancer cells

Author:
Zhang, Haiyu; Wang, Zichao; Wang, Fengxia; Wang, Chengdong; Zhang, Hui
Source:
Archives of biochemistry and biophysics 2020 v.684 pp. 108334
ISSN:
0003-9861
Subject:
interleukin-8,   etc   ; animal ovaries; cisplatin; histone code; interleukin-6; messenger RNA; neoplasm cells; ovarian neoplasms; screening; therapeutics; tissues;     Show all 11 Subjects
Abstract:
... Emerging evidence shows that histone modification and its related regulators are involved in the progression and chemoresistance of ovarian cancer (OC) cells. Our present study found that the expression of Jumonji C domain-containing 2A (JMJD2A), while not JMJD2B or JMJD2C, is increased in OC cells and tissues as compared with that in their corresponding controls. Knockdown of JMJD2A can decrease ...
DOI:
10.1016/j.abb.2020.108334

3. Conservation of eATP perception throughout multicellular animal evolution: Identification and functional characterization of coral and amphioxus P2X7-like receptors and flounder P2X7 receptor

Author:
Duan, Huimin; Ni, Shousheng; Yang, Shuaiqi; Zhou, Yang; Zhang, Yu; Zhang, Shicui
Source:
Developmental and comparative immunology 2020 v.106 pp. 103641
ISSN:
0145-305X
Subject:
interleukin-8,   etc   ; adenosine triphosphate; corals; flounder; humans; interleukin-1beta; interleukin-6; phagocytosis; plasma membrane; receptors; signal transduction;     Show all 11 Subjects
Abstract:
... Perception of extracellular ATP (eATP), a common endogenous damage-associated molecular pattern, is through its receptor P2X7R. If eATP/P2X7R signaling is conserved throughout animal evolution is unknown. Moreover, little information is currently available regarding P2X7R in invertebrates. Here we demonstrated that the coral P2X7-like receptor, AdP2X7RL, the amphioxus P2X7-like receptor, BjP2X7RL ...
DOI:
10.1016/j.dci.2020.103641

4. Sesquiterpenoids from Pilea aquarum subsp. brevicornuta

Author:
Zhou, Pengjun; Hu, Jiachun; Wen, Baoying; Ding, Jie; Lou, Bin; Xiong, Juan; Yang, Guoxun; Hu, Jinfeng
Source:
Tetrahedron 2020 v.76 no.13 pp. 131026
ISSN:
0040-4020
Subject:
interleukin-8,   etc   ; Pilea; X-ray diffraction; chemical reactions; chemical structure; human cell lines; interleukin-1beta; quantum mechanics; sesquiterpenoids; spectroscopy;     Show all 10 Subjects
Abstract:
... Four new sesquiterpenoids named pileaterpenes A-D (1–4), together with three known sesquiterpenoids (5–7), were isolated from Pilea aquarum subsp. brevicornuta. The chemical structures of the new compounds were tentatively established by extensive spectroscopic methods and quantum chemical calculations. The absolute configurations of 1–3 were further determined by X-ray crystal diffraction, the mo ...
DOI:
10.1016/j.tet.2020.131026

5. Characterization of Gardnerella vaginalis membrane vesicles reveals a role in inducing cytotoxicity in vaginal epithelial cells

Author:
Shishpal, Parul; Kasarpalkar, Nandini; Singh, Dipty; Bhor, Vikrant M.
Source:
Anaerobe 2020 v.61 pp. 102090
ISSN:
1075-9964
Subject:
interleukin-8,   etc   ; Gardnerella vaginalis; cytotoxicity; epithelial cells; erythrocytes; liquid chromatography; mass spectrometry; metabolism; molecular chaperones; pathogenesis; proteomics; virulence; women;     Show all 13 Subjects
Abstract:
... Bacterial vaginosis (BV) is a common polymicrobial infection affecting women in the reproductive age and is associated with adverse obstetric and gynaecological outcomes. Gardnerella vaginalis is the most virulent anaerobic bacterial species predominantly associated with BV. However, a clear understanding of the mechanisms by which it contributes to the pathogenesis and persistence of BV is lackin ...
DOI:
10.1016/j.anaerobe.2019.102090

6. Wash-Free, Digital Immunoassay in Polydisperse Droplets

Author:
Byrnes, Samantha A.; Huynh, Toan; Chang, Tim C.; Anderson, Caitlin E.; McDermott, James J.; Oncina, Ciela I.; Weigl, Bernhard H.; Nichols, Kevin P.
Source:
Analytical chemistry 2020 v.92 no.5 pp. 3535-3543
ISSN:
1520-6882
Subject:
interleukin-8,   etc   ; biomarkers; blood; detection limit; droplets; fluorescence microscopes; immunoassays; laboratory equipment; point-of-care systems; proteins; stochastic processes;     Show all 11 Subjects
Abstract:
... Immunoassays are important for the detection of proteins to enable disease identification and monitor treatment, but many immunoassays suffer from sensitivity limitations. The development of digital assays has enabled highly sensitive biomarker detection and quantification, but the necessary devices typically require precisely controlled volumes to reduce biases in concentration estimates from com ...
DOI:
10.1021/acs.analchem.9b02526

7. Silencing KPNA2 inhibits IL-6-induced breast cancer exacerbation by blocking NF-κB signaling and c-Myc nuclear translocation in vitro

Author:
Duan, Mingyue; Hu, Fei; Li, Dan; Wu, Shouzhen; Peng, Niancai
Source:
Life sciences 2020 v.253 pp. 117736
ISSN:
0024-3205
Subject:
interleukin-8,   etc   ; breast neoplasms; carcinogenesis; inflammation; interleukin-17; interleukin-6; karyopherins; loss-of-function mutation; models; nucleocytoplasmic transport; secretion; therapeutics; transcription factor NF-kappa B;     Show all 13 Subjects
Abstract:
... Recently, studies indicated that inflammation could exacerbate the development of BC. Karyopherin α-2 (KPNA2) is a molecule which modulates nucleocytoplasmic transport and is involved in malignant cellular behavior and carcinogenesis. Our study aims to elucidate the role of KPNA2 in BC pathogenesis and explore the mechanism of KPNA2 in regulating inflammation-induced BC exacerbations.We measured t ...
DOI:
10.1016/j.lfs.2020.117736

8. Passion fruit (Passiflora edulis) leaf aqueous extract ameliorates intestinal epithelial barrier dysfunction and reverts inflammatory parameters in Caco-2 cells monolayer

Author:
Cristina Lopes do Carmo, Mônica; Mateus Martins, Isabela; Elisa Ramos Magalhães, Ana; Roberto Maróstica Júnior, Mário; Alves Macedo, Juliana
Source:
Food research international 2020 v.133 pp. 109162
ISSN:
0963-9969
Subject:
interleukin-8,   etc   ; Passiflora edulis; anti-inflammatory activity; antioxidants; electrical resistance; epithelium; human cell lines; interleukin-1beta; intestines; leaves; passion fruits; permeability; polyphenols; protective effect;     Show all 14 Subjects
Abstract:
... The aqueous extract of Passiflora edulis leaves is rich in bioactive polyphenolics, with antioxidant and anti-inflammatory properties. In this study, the recovery of barrier dysfunction and the anti-inflammatory effect of P. edulis leaf aqueous extract (PELE) were evaluated using a Caco-2 monolayer model challenged with IL-1β and LPS. After inflammatory stimuli, it was observed a 28% reduction in ...
DOI:
10.1016/j.foodres.2020.109162

9. lncRNA TUG1 regulates ulcerative colitis through miR-142-5p/SOCS1 axis

Author:
Han, Jing; Li, Yawei; Zhang, Baolian; Liu, Hong; Wu, Mengyao; Zhang, Xiaolan
Source:
Microbial pathogenesis 2020 v.143 pp. 104139
ISSN:
0882-4010
Subject:
interleukin-8,   etc   ; cell viability; colon; inflammation; interleukin-1beta; interleukin-6; lactate dehydrogenase; models; mucosa; nitrites; non-coding RNA; patients; rectum; tumor necrosis factor-alpha; ulcerative colitis;     Show all 15 Subjects
Abstract:
... Ulcerative colitis (UC) is a long-lasting inflammation disease which finally results in ulcer of the colon and rectum. The long non-coding RNA (lncRNA) TUG1 has been described to target miR-142 and regulate its expression. In current study, we evaluated the effects of long non-coding RNA TUG1 on cell injury and inflammatory cytokine production using a TNFα-treated HT-29 cells model. We monitored t ...
DOI:
10.1016/j.micpath.2020.104139

10. Does tumour necrosis factor alpha-induced cyclooxygenase-2 expression lead to spontaneous abortion in Chlamydia trachomatis-infected women

Author:
Singh, Namita; Prasad, Priya; Das, Banashree; Rastogi, Sangita
Source:
Microbial pathogenesis 2020 v.142 pp. 103994
ISSN:
0882-4010
Subject:
interleukin-8,   etc   ; Chlamydia trachomatis; abortion (animals); endometrium; gene expression; genes; interferon-gamma; messenger RNA; pregnant women; prostaglandin synthase; quantitative polymerase chain reaction; tumor necrosis factor-alpha; India;     Show all 13 Subjects
Abstract:
... Cytokines might be involved in spontaneous abortion by triggering inflammatory mediators (Cyclooxygenases (Cox)) leading to spontaneous abortion in Chlamydia trachomatis (Ct)-infected women. Study aimed to quantitate the expression of pro-inflammatory cytokines (TNF-α, IFN-γ, IL-8) and Cox-2 in endometrial curettage tissue (ECT) of Spontaneous Aborters (SA). SA (n = 135) and 120 age-matched contro ...
DOI:
10.1016/j.micpath.2020.103994

11. virB11 gene potentially involves in ATP metabolism to provide energy in H. pylori infection

Author:
Sun, Da-Lin; Gong, Zhen-Hua; Shao, Shu-Li; Shi, Xiao-Lin; Yuan, Xiao-Yan; Luo, Hong; Wang, Ming-Yi
Source:
Microbial pathogenesis 2020 v.142 pp. 104067
ISSN:
0882-4010
Subject:
interleukin-8,   etc   ; H+/K+-exchanging ATPase; H-transporting ATP synthase; adenosine triphosphate; antibody formation; bacteria; bioinformatics; cell membranes; coculture; cytotoxicity; energy; hydrophilicity; isocitrate dehydrogenase; metabolism; proteins; structural genes;     Show all 16 Subjects
Abstract:
... Helicobater pylori (H. pylori) is the most important bacteria known to be associated with various gastroduodenal diseases. virB11 gene is a structural gene of tfs3a genes cluster in the plasticity region of H. pylori. In this study, the structure and biology of virB11 gene were analyzed and elucidated with bioinformatics analysis. After cloning, expression and purification, VirB11 protein was gene ...
DOI:
10.1016/j.micpath.2020.104067

12. Keratinocytes are capable of selectively sensing low amounts of graphene-based materials: Implications for cutaneous applications

Author:
Fusco, Laura; Pelin, Marco; Mukherjee, Sourav; Keshavan, Sandeep; Sosa, Silvio; Martín, Cristina; González, Viviana; Vázquez, Ester; Prato, Maurizio; Fadeel, Bengt; Tubaro, Aurelia
Source:
Carbon 2020 v.159 pp. 598-610
ISSN:
0008-6223
Subject:
interleukin-8,   etc   ; cell movement; cell viability; coculture; exposure pathways; graphene; graphene oxide; humans; inflammation; interleukin-6; keratinocytes; monocytes; secretion; tumor necrosis factor-alpha;     Show all 14 Subjects
Abstract:
... Skin provides the first interface between body and environment, representing one of the most feasible exposure routes to graphene-based materials (GBMs). However, interactions of GBMs with the skin are poorly understood. In particular, low-concentration effects have not been investigated. Here we explored the ability of endotoxin-free, few-layer graphene (FLG) and dehydrated graphene oxide (d-GO) ...
DOI:
10.1016/j.carbon.2019.12.064

13. Improvement of human pancreatic islet quality after co-culture with human adipose-derived stem cells

Author:
de Souza, Bianca M.; Rodrigues, Michelle; de Oliveira, Fernanda S.; da Silva, Liana P.A.; Bouças, Ana P.; Portinho, Ciro P.; dos Santos, Bruno P.; Camassola, Melissa; Rocha, Dagoberto; Lysakowski, Simone; Martini, Juliano; Leitão, Cristiane B.; Nardi, Nance B.; Bauer, Andrea C.; Crispim, Daisy
Source:
Molecular and cellular endocrinology 2020 v.505 pp. 110729
ISSN:
0303-7207
Subject:
interleukin-8,   etc   ; chemokine CCL2; coculture; gene expression regulation; genes; humans; interleukin-10; interleukin-6; islets of Langerhans; protective effect; protein content; stem cells; tumor necrosis factors; viability;     Show all 14 Subjects
Abstract:
... The aim of this study was to investigate whether co-culture of human islets with adipose-derived stem cells (ASCs) can improve islet quality and to evaluate which factors play a role in the protective effect of ASCs against islet dysfunction. Islets and ASCs were cultured in three experimental groups for 24 h, 48 h, and 72 h: 1) indirect co-culture of islets with ASC monolayer (Islets/ASCs); 2) is ...
DOI:
10.1016/j.mce.2020.110729

14. Biogenic silver nanoparticles reduce adherence, infection, and proliferation of toxoplasma gondii RH strain in HeLa cells without inflammatory mediators induction

Author:
Machado, Laís Fernanda; Sanfelice, Raquel Arruda; Bosqui, Larissa Rodrigues; Assolini, João Paulo; Scandorieiro, Sara; Navarro, Italmar Teodorico; Depieri Cataneo, Allan Henrique; Wowk, Pryscilla Fanini; Nakazato, Gerson; Bordignon, Juliano; Pavanelli, Wander Rogerio; Conchon-Costa, Ivete; Costa, Idessania Nazareth
Source:
Experimental parasitology 2020 v.211 pp. 107853
ISSN:
0014-4894
Subject:
interleukin-8,   etc   ; Toxoplasma gondii; antiparasitic properties; dose response; drugs; human cell lines; nanoparticles; nanosilver; nitric oxide; reactive oxygen species; therapeutics; toxicity; toxoplasmosis; viability assays;     Show all 14 Subjects
Abstract:
... The highlights of biogenic silver nanoparticles (AgNp-Bio) include low toxicity – depending on size and concentration – and efficient antiparasitic activity. Therefore, the objective of this study was to assess the action of the AgNp-Bio on HeLa cells in an infection with strain of RH Toxoplasma gondii. Firstly, we performed a cellular viability test and characterized the AgNp-Bio to proceed with ...
DOI:
10.1016/j.exppara.2020.107853

15. Application of the TruCulture® whole blood stimulation system for immune response profiling in cattle

Author:
O’Brien, Megan B.; McLoughlin, Rachel M.; Meade, Kieran G.
Source:
Veterinary immunology and immunopathology 2020 v.221 pp. 110025
ISSN:
0165-2427
Subject:
interleukin-8,   etc   ; Holstein; blood; blood volume; bulls; calves; cell viability; flow cytometry; hematology; humans; hypoxia; immune response; interleukin-1beta; pathogen-associated molecular patterns; phenotype; phenotypic variation; vaccination; zymosan;     Show all 18 Subjects
Abstract:
... Capturing the phenotypic variation in immune responses holds enormous promise for the development of targeted treatments for disease as well as tailored vaccination schedules. However, accurate detection of true biological variation can be obscured by the lack of standardised immune assays. The TruCulture® whole blood stimulation system has now been extensively used to detect basal and induced imm ...
DOI:
10.1016/j.vetimm.2020.110025

16. Biotransformation processes in soymilk isoflavones to enhance anti‐inflammatory potential in intestinal cellular model

Author:
Hiramatsu, Erika Yumi; de Ávila, Amanda Rejane Alves; Gênova, Vanize Martins; de Queirós, Lívia Dias; Macedo, Gabriela Alves; Martins, Isabela Mateus; Macedo, Juliana Alves
Source:
Journal of food biochemistry 2020 v.44 no.3 pp. e13149
ISSN:
0145-8884
Subject:
interleukin-8,   etc   ; adjuvants; anti-inflammatory activity; antioxidant activity; biotransformation; dietary supplements; glycosylation; inflammation; intestines; isoflavones; metabolites; models; probiotics; reactive oxygen species; soybeans; soymilk; tannase;     Show all 17 Subjects
Abstract:
... The present study investigated, in in vitro cellular model, the modulation of intestinal inflammation by biotransformed soymilk with tannase and probiotic strains. The ability to reduce the generation of intracellular reactive oxygen species (ROS) and the antioxidant power of soy extracts were also evaluated. The results showed changes in isoflavones profile after biotransformation processes, with ...
DOI:
10.1111/jfbc.13149

17. Cytokine tear film profile determination in eyes of healthy dogs and those with inflammatory periocular and skin disorders

Author:
Martinez, P.S.; Pucheu, C.M.; Liu, C.C.; Carter, R.T.
Source:
Veterinary immunology and immunopathology 2020 v.221 pp. 110012
ISSN:
0165-2427
Subject:
interleukin-8,   etc   ; blood serum; dogs; eyes; humans; immune response; interferon-gamma; interleukin-10; interleukin-2; interleukin-6; interleukin-7; patients; skin diseases; tumor necrosis factor-alpha;     Show all 14 Subjects
Abstract:
... Alterations in serum cytokine levels and profiles have been reported in association with a variety of disease conditions (e.g., allergic, immune-mediated, etc.) in both humans and animals. In comparison to serum cytokine measurements, tear cytokine measurements might be expected to more accurately reflect the inflammatory milieu associated with periocular disease. The purpose of this study was to ...
DOI:
10.1016/j.vetimm.2020.110012

18. Effect of the Antimicrobial Peptide LL-37 on Gene Expression of Chemokines and 29 Toll-like Receptor-Associated Proteins in Human Gingival Fibroblasts Under Stimulation with Porphyromonas gingivalis Lipopolysaccharide

Author:
Inomata, Megumi; Horie, Toshi; Into, Takeshi
Source:
Probiotics and antimicrobial proteins 2020 v.12 no.1 pp. 64-72
ISSN:
1867-1306
Subject:
interleukin-8,   etc   ; Porphyromonas gingivalis; Toll-like receptor 4; antagonists; antimicrobial peptides; chemokine CCL2; chemokine CXCL10; cytotoxicity; fibroblasts; gene expression; gene expression regulation; genes; humans; ligands; lipopolysaccharides; neutralization;     Show all 16 Subjects
Abstract:
... The antimicrobial peptide LL-37 neutralizes the biological activity of lipopolysaccharide (LPS), while it upregulates the expression of several immune-related genes. We investigated the effect of LL-37 on gene regulation of human gingival fibroblasts (HGFs), stimulated with or without Porphyromonas gingivalis-derived LPS, a ligand for Toll-like receptor (TLR). LL-37 was non-toxic to HGFs up to a c ...
DOI:
10.1007/s12602-019-09600-2

19. The effect of probiotics on inflammatory biomarkers: a meta-analysis of randomized clinical trials

Author:
Milajerdi, Alireza; Mousavi, Seyyed Mohammad; Sadeghi, Alireza; Salari-Moghaddam, Asma; Parohan, Mohammad; Larijani, Bagher; Esmaillzadeh, Ahmad
Source:
European journal of nutrition 2020 v.59 no.2 pp. 633-649
ISSN:
1436-6207
Subject:
interleukin-8,   etc   ; adults; biomarkers; blood serum; inflammation; interleukin-10; interleukin-12; interleukin-17; interleukin-4; interleukin-6; meta-analysis; probiotics; randomized clinical trials; systematic review;     Show all 14 Subjects
Abstract:
... PURPOSE: No study has summarized earlier findings on the effect of probiotic supplementation on inflammatory biomarkers. This systematic review and meta-analysis was conducted to systematically review the available placebo-controlled clinical trials about the effect of probiotic supplementation on several inflammatory biomarkers in adults. METHODS: Relevant papers published up to March 2018 were s ...
DOI:
10.1007/s00394-019-01931-8

20. Effect of Zataria multiflora on serum cytokine levels and pulmonary function tests in sulfur mustard-induced lung disorders: A randomized double-blind clinical trial

Author:
Khazdair, Mohammad Reza; Ghorani, Vahideh; Alavinezhad, Azam; Boskabady, Mohammad Hossein
Source:
Journal of ethnopharmacology 2020 v.248 pp. 112325
ISSN:
0378-8741
Subject:
interleukin-8,   etc   ; Zataria multiflora; blood serum; clinical trials; inflammation; interferon-gamma; interleukin-10; interleukin-2; interleukin-6; lung function; lungs; patients; placebos; plant extracts; sulfur; traditional medicine;     Show all 16 Subjects
Abstract:
... Zataria multiflora (Z. multiflora) belongs to the Lamiaceae family and has several traditional uses owing to its antiseptic, aesthetic, antispasmodic, analgesic, and antidiarrheal properties.We aimed to investigate the effect of Z. multiflora on serum cytokine levels and pulmonary function tests (PFT) in patients exposed to sulfur mustard (SM) for a long term (27–30 years).Thirty-five patients wer ...
DOI:
10.1016/j.jep.2019.112325