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1. Correction: Rational design of a peptide capture agent for CXCL8 based on a model of the CXCL8:CXCR1 complex

Author:
Helmer, Dorothea; Rink, Ina; Dalton, James A. R.; Brahm, Kevin; Jöst, Marina; Nargang, Tobias M.; Blum, Witali; Wadhwani, Parvesh; Brenner-Weiss, Gerald; Rapp, Bastian E.; Giraldo, Jesús; Schmitz, Katja
Source:
RSC advances 2018 v.8 no.30 pp. 16800-16801
ISSN:
2046-2069
Subject:
interleukin-8,   etc   ; models; synthesis;     Show all 3 Subjects
Abstract:
... Correction for ‘Rational design of a peptide capture agent for CXCL8 based on a model of the CXCL8:CXCR1 complex’ by Dorothea Helmer et al., RSC Adv., 2015, 5, 25657–25668. ...
DOI:
10.1039/c8ra90035c

2. Assessment of seven protocols to prepare Cutibacterium acnes bacterial lysates to measure its immunogenic potential and review of the literature

Author:
Dagnelie, Marie-Ange; Khammari, Amir; Dréno, Brigitte; Corvec, Stéphane
Source:
Anaerobe 2019 v.57 pp. 75-81
ISSN:
1075-9964
Subject:
interleukin-8,   etc   ; artificial skin; bacteria; cell walls; explants; freezing; sonication; thawing;     Show all 8 Subjects
Abstract:
... Seven protocols were tested to prepare cell wall extracts from live Cutibacterium acnes. Different parameters were modified: thawing/freezing and sonication/freezing cycles, to impact on mechanical degradation of the bacteria. Finally, the immunogenic potential of the extracts generated was evaluated by measuring IL-8 releases using an in vitro skin explants system. The aim of this article was to ...
DOI:
10.1016/j.anaerobe.2019.03.019

3. Conformation, allergenicity and human cell allergy sensitization of tropomyosin from Exopalaemon modestus: Effects of deglycosylation and Maillard reaction

Author:
Zhang, Ziye; Xiao, Hang; Zhang, Xiaofeng; Zhou, Peng
Source:
Food chemistry 2019 v.276 pp. 520-527
ISSN:
0308-8146
Subject:
interleukin-8,   etc   ; Maillard reaction; allergenicity; colon; digestibility; digestion; glucose; glycation; glycoproteins; humans; hypersensitivity; tropomyosins;     Show all 12 Subjects
Abstract:
... Tropomyosin (TM) from Exopalaemon modestus was glycoprotein, the effects of deglycosylation (enzyme and chemical regents) and Maillard reaction on the conformation, allergenicity and human cell sensitization of TM were investigated. TM had both N-glycan and O-glycan. After deglycosylation and glycation, the α-helix of TM reduced, while other secondary structures promoted. Deglycosylation enhanced ...
DOI:
10.1016/j.foodchem.2018.10.032

4. Human αS1-casein induces IL-8 secretion by binding to the ecto-domain of the TLR4/MD2 receptor complex

Author:
Saenger, Thorsten; Vordenbäumen, Stefan; Genich, Swetlana; Haidar, Samer; Schulte, Marten; Nienberg, Christian; Bleck, Ellen; Schneider, Matthias; Jose, Joachim
Source:
Biochimica et biophysica acta 2019 v.1863 no.3 pp. 632-643
ISSN:
0304-4165
Subject:
interleukin-8,   etc   ; Toll-like receptor 4; alphaS1-casein; antagonists; humans; secretion;     Show all 6 Subjects
Abstract:
... The milk protein αS1-casein was recently reported to induce secretion of proinflammatory cytokines via Toll-like receptor 4 (TLR4). In this study, αS1-casein was identified as binder of theTLR4 ecto domain.IL-8 secretion after stimulation of TLR4/MD2 (myeloid differentiation factor 2)/CD14 (cluster of differentiation 14)-transfected HEK293 cells (TLR4+) and Mono Mac 6 cells (MM6) with recombinant ...
DOI:
10.1016/j.bbagen.2018.12.007

5. Changes in Gene Expression in Human Epithelial and Mast Cells in Response to Vesicles from Klebsiella pneumonia ATCC 13883

Author:
You, Hee Sang; Ok, Yeon Jeong; Lee, Song Hee; Kang, Sang Sun; Hyun, Sung Hee
Source:
Indian journal of microbiology 2019 v.59 no.2 pp. 241-245
ISSN:
0046-8991
Subject:
interleukin-8,   etc   ; Klebsiella pneumoniae; chemokine CCL3; epithelial cells; epithelium; gene expression; gene expression regulation; genes; immune response; mast cells; pathogenicity;     Show all 11 Subjects
Abstract:
... We investigated alterations in the expression of immune-related genes in epithelial cells and mast cells treated with outer membrane vesicles (OMVs) derived from Klebsiella pneumoniae (KpOMVs). Previous studies have shown that OMVs contain substances that enable their delivery to host cells and induce an immune response. Our results indicate an increase in expression of genes such as IL-8, IL-1b, ...
DOI:
10.1007/s12088-018-0774-5

6. Interleukin (IL)-8 polymorphisms and risk of prostate disorders

Author:
Taheri, Mohammad; Noroozi, Rezvan; Dehghan, Arash; Roozbahani, Golnaz Atri; Omrani, Mir Davood; Ghafouri-Fard, Soudeh
Source:
Gene 2019 v.692 pp. 22-25
ISSN:
0378-1119
Subject:
interleukin-8,   etc   ; alleles; biomarkers; genotyping; haplotypes; hyperplasia; males; models; pathogenesis; patients; prostatic neoplasms; risk; single nucleotide polymorphism;     Show all 13 Subjects
Abstract:
... Prostate cancer (PCa) and benign prostate hyperplasia (BPH) as two prevalent age-related disorders in male have some shared genetic and immunological underlying mechanisms. However, researchers have aimed at identification of specific biomarkers with the ability to differentiate between these disorders. In the present study, we genotyped the rs4073, rs2227306 and rs1126647 single nucleotide polymo ...
DOI:
10.1016/j.gene.2019.01.005

7. Functionality of the Interleukin 8 haplotypes in lymphocytes and macrophages in response to gram-negative periodontopathogens

Author:
Pigossi, Suzane C.; Anovazzi, Giovana; Finoti, Livia S.; de Medeiros, Marcell C.; Mayer, Marcia P.A.; Rossa Junior, Carlos; Scarel-Caminaga, Raquel M.
Source:
Gene 2019 v.689 pp. 152-160
ISSN:
0378-1119
Subject:
interleukin-8,   etc   ; Gram-negative bacteria; chemotaxis; gene expression; genes; haplotypes; infectious diseases; lymphocytes; macrophages; monocytes; patients; periodontitis; phagocytosis; phenotype;     Show all 14 Subjects
Abstract:
... Individuals carrying the ATC/TTC haplotype (Hap-1) in the interleukin 8 (IL8) gene were reported as more susceptible to chronic periodontitis (CP), an infectious disease associated with Gram-negative bacteria, in comparison to patients with the ATT/TTC haplotype (Hap-2). This study investigated the functionality of the IL8 haplotypes in lymphocytes and monocytes of individuals carrying the Hap-1 o ...
DOI:
10.1016/j.gene.2018.12.012

8. Interferences of anthocyanins with the uptake of lycopene in Caco-2 cells, and their interactive effects on anti-oxidation and anti-inflammation in vitro and ex vivo

Author:
Phan, Minh Anh Thu; Bucknall, Martin P.; Arcot, Jayashree
Source:
Food chemistry 2019 v.276 pp. 402-409
ISSN:
0308-8146
Subject:
interleukin-8,   etc   ; anthocyanidins; anthocyanins; anti-inflammatory activity; antioxidant activity; antioxidants; biomarkers; glucosides; human cell lines; lycopene; models; synergism;     Show all 12 Subjects
Abstract:
... Lycopene was combined with the glucosides of each of the six common anthocyanidins at 3 different ratios to investigate their interactions on antioxidant and anti-inflammatory activities, and cellular uptake. The bioactivity interaction between lycopene and anthocyanins was studied in both chemical and cellular models. Anti-oxidative synergy was not seen in any of the tested lycopene-anthocyanin m ...
DOI:
10.1016/j.foodchem.2018.10.012

9. Rapid initiation of guided bone regeneration driven by spatiotemporal delivery of IL-8 and BMP-2 from hierarchical MBG-based scaffold

Author:
Lin, Dan; Chai, Yanjun; Ma, Yifan; Duan, Bing; Yuan, Yuan; Liu, Changsheng
Source:
Biomaterials 2019 v.196 pp. 122-137
ISSN:
0142-9612
Subject:
interleukin-8,   etc   ; advanced regeneration; biocompatible materials; bone mineralization; cartilage; genes; glass; histology; porous media; receptors; stem cells; synergism;     Show all 12 Subjects
Abstract:
... Initiation of endogenous repair mechanisms, including key steps of stem cell recruitment and cartilage intermediate formation in endochondral ossification, is vital to regeneration of large bone defects. To biomimetically promote a rapid initiation and ensuing osteogenic stimulation, exogenous chemokine IL-8 and growth factor BMP-2 were orchestrated in a mesoporous bioactive glass (MBG)-based spat ...
DOI:
10.1016/j.biomaterials.2017.11.011

10. Fine-Tuning of GPCR–Chemokine Interactions. Design and Identification of Chemokine Analogues as Receptor Agonists, Biased Agonists, and Antagonists

Author:
Navarro, Javier
Source:
Biochemistry 2019 v.58 no.10 pp. 1432-1439
ISSN:
1520-4995
Subject:
interleukin-8,   etc   ; CXCR1 receptor; CXCR2 receptor; agonists; antagonists; calcium; carcinogenesis; chemotaxis; immune response; leukocytes; metastasis; models; phosphorylation; zinc; zinc chloride;     Show all 15 Subjects
Abstract:
... Chemokines play important roles in immune defense by directing migration of leukocytes and serve as key promoters of tumorigenesis and metastasis. This study explores the molecular mechanisms of recognition and activation of two homologous chemokine receptors, CXCR1 and CXCR2, using CXCL8 analogues with residue substitutions in the conserved Glu4Leu5Arg6 (ELR) triad. Analysis of the binding of CXC ...
DOI:
10.1021/acs.biochem.8b01266

11. Association of IL-8-251 A/T rs4073 and IL-10 rs1800872 -592C/A Polymorphisms and Coronary Artery Disease in North Indian Population

Author:
Kaur, Naindeep; Singh, Jagtar; Reddy, S.
Source:
Biochemical genetics 2019 v.57 no.1 pp. 129-146
ISSN:
0006-2928
Subject:
interleukin-8,   etc   ; coronary artery disease; females; genetic polymorphism; genotyping; heterozygosity; interleukin-10; males; morbidity; mutants; patients; risk;     Show all 12 Subjects
Abstract:
... CAD (Coronary Artery Disease) morbidity is becoming an endemic worldwide. Recently, the role of pro- and anti-inflammatory cytokines in the development of atherosclerotic plaques has been explored, but the association of their genetic polymorphisms and CAD has yet not been established. The present study aimed to investigate the association of IL-8-251A/T (rs4073) and IL-10 -592C/A (rs1800872) poly ...
DOI:
10.1007/s10528-018-9880-7

12. IL8 and EDEM3 gene expression ratio indicates peripheral blood mononuclear cell (PBMC) quality

Author:
Kofanova, Olga; Bellora, Camille; Quesada, Rocio Aguilar; Bulla, Alexandre; Panadero-Fajardo, Sonia; Keipes, Marc; Shea, Kathi; Stone, Mars; Lescuyer, Pierre; Betsou, Fay
Source:
Journal of immunological methods 2019 v.465 pp. 13-19
ISSN:
0022-1759
Subject:
interleukin-8,   etc   ; EDTA (chelating agent); RNA; ambient temperature; anticoagulants; blood sampling; citrates; gene expression; mononuclear leukocytes; patients;     Show all 10 Subjects
Abstract:
... Uncontrolled preanalytical variables can reduce the accuracy and reproducibility of downstream analytical results from peripheral blood mononuclear cells (PBMCs).PBMCs were isolated from EDTA and citrate-anticoagulated blood samples, obtained from healthy subjects and patients with inflammatory and infectious conditions. PBMC-derived RNA samples were examined for gene expression changes induced by ...
DOI:
10.1016/j.jim.2018.11.012

13. Oleuropein aglycone attenuates the pro-angiogenic phenotype of senescent fibroblasts: A functional study in endothelial cells

Author:
Margheri, Francesca; Menicacci, Beatrice; Laurenzana, Anna; Del Rosso, Mario; Fibbi, Gabriella; Cipolleschi, Maria Grazia; Ruzzolini, Jessica; Nediani, Chiara; Mocali, Alessandra; Giovannelli, Lisa
Source:
Journal of functional foods 2019 v.53 pp. 219-226
ISSN:
1756-4646
Subject:
interleukin-8,   etc   ; Mediterranean diet; angiogenesis; cardiovascular diseases; endothelial cells; fibroblasts; morphogenesis; neoplasms; oleuropein; phenotype; secretion; vascular endothelial growth factors;     Show all 12 Subjects
Abstract:
... The “senescence-associated secretory phenotype” (SASP) supports a pro-tumoral and pro-angiogenic microenvironment through increased secretion of inflammatory and growth factors. We investigated oleuropein aglycone (OLE, 10 µM, 5 weeks) effect on capillary morphogenesis induced by MRC5 fibroblast SASP in mature (hMVEC) and progenitor (ECFC) endothelial cells. In senescent fibroblasts OLE reduced NF ...
DOI:
10.1016/j.jff.2018.12.026

14. Allergenicity suppression of tropomyosin from Exopalaemon modestus by glycation with saccharides of different molecular sizes

Author:
Zhang, Ziye; Xiao, Hang; Zhou, Peng
Source:
Food chemistry 2019 v.288 pp. 268-275
ISSN:
0308-8146
Subject:
interleukin-8,   etc   ; allergenicity; basophils; colon; epithelial cells; epitopes; food allergies; glucose; glycation; human cell lines; humans; immunoblotting; maltose; maltotriose; mitogen-activated protein kinase; molecular weight; secretion; tropomyosins;     Show all 18 Subjects
Abstract:
... The allergenicity suppression of tropomyosin (TM) from Exopalaemon modestus by glycation with saccharides of different molecular sizes (glucose, maltose, maltotriose, maltopentaose and maltoheptaose) was investigated using immunoblotting, human colon epithelial cell line (Caco-2) and human basophil cell line (KU812). Glycation of TM by glucose, maltotriose, maltopentaose and maltoheptaose signific ...
DOI:
10.1016/j.foodchem.2019.03.019

15. Combined effects of okadaic acid and pectenotoxin-2, 13-desmethylspirolide C or yessotoxin in human intestinal Caco-2 cells

Author:
Alarcan, Jimmy; Barbé, Sabrina; Kopp, Benjamin; Hessel-Pras, Stefanie; Braeuning, Albert; Lampen, Alfonso; Le Hégarat, Ludovic; Fessard, Valérie
Source:
Chemosphere 2019 v.228 pp. 139-148
ISSN:
0045-6535
Subject:
interleukin-8,   etc   ; DNA damage; cell viability; cytotoxicity; human cell lines; human health; inflammation; intestines; lipophilicity; mathematical models; okadaic acid; oxidative stress; secondary metabolites; shellfish; synergism; yessotoxin;     Show all 16 Subjects
Abstract:
... Lipophilic phycotoxins are secondary metabolites produced by phytoplanktonic species. They accumulate in filtering shellfish and can cause human intoxications. Humans can be exposed to combinations of several phycotoxins. The toxicological effects of phycotoxin mixtures on human health are largely unknown. Published data on phycotoxin co-exposure show that okadaic acid (OA) is simultaneously found ...
DOI:
10.1016/j.chemosphere.2019.04.018

16. Effects on intestinal cellular bioaccessibility of carotenoids and cellular biological activity as a consequence of co-ingestion of anthocyanin- and carotenoid-rich vegetables

Author:
Phan, Minh Anh Thu; Bucknall, Martin P; Arcot, Jayashree
Source:
Food chemistry 2019 v.286 pp. 678-685
ISSN:
0308-8146
Subject:
interleukin-8,   etc   ; alpha-carotene; anaerobic digestion; anti-inflammatory activity; antioxidants; beta-carotene; bioavailability; cabbage; carrots; cherry tomatoes; intestines; lutein; lycopene; nitric oxide; secretion; spinach;     Show all 16 Subjects
Abstract:
... The effects of co-digestion of a carotenoid-rich vegetable such as carrot, cherry tomato or baby spinach with an anthocyanin-rich vegetable such as red cabbage with and without salad dressing on the intestinal cellular bioaccessibility (cBAC) of carotenoids and the resultant cellular antioxidant and anti-inflammatory activities were investigated. The % cBAC of lutein from the tested vegetables was ...
DOI:
10.1016/j.foodchem.2019.02.046

17. The effect of DNA methylation on the miRNA expression pattern in lipopolysaccharide-induced inflammatory responses in human dental pulp cells

Author:
Mo, Zehuan; Li, Qimeng; Cai, Luhui; Zhan, Minkang; Xu, Qiong
Source:
Molecular immunology 2019 v.111 pp. 11-18
ISSN:
0161-5890
Subject:
interleukin-8,   etc   ; DNA; DNA methylation; epigenetics; gene expression; high-throughput nucleotide sequencing; humans; inflammation; interleukin-6; lipopolysaccharides; messenger RNA; methyltransferases; microRNA; protein content; pulp; tooth pulp;     Show all 16 Subjects
Abstract:
... Endodontic infection is a widespread oral problem. DNA methylation is a key epigenetic modification that plays important roles in various inflammatory responses, but its role in dental pulp inflammation is poorly understood. In this study, we assessed the expression of DNA methyltransferases (DNMTs) in human dental pulp cells (hDPCs) during lipopolysaccharide (LPS)-induced inflammation and found th ...
DOI:
10.1016/j.molimm.2019.03.012

18. A bio-guided assessment of the anti-inflammatory activity of hop extracts (Humulus lupulus L. cv. Cascade) in human gastric epithelial cells

Author:
Sangiovanni, Enrico; Fumagalli, Marco; Santagostini, Laura; Forino, Martino; Piazza, Stefano; Colombo, Elisa; Taglialatela-Scafati, Orazio; Fico, Gelsomina; Dell'Agli, Mario
Source:
Journal of functional foods 2019 v.57 pp. 95-102
ISSN:
1756-4646
Subject:
interleukin-8,   etc   ; Humulus lupulus; active ingredients; anti-inflammatory activity; chalcones; epithelial cells; fractionation; gastric mucosa; in vitro digestion; inflammation; models; secretion; tumor necrosis factor-alpha;     Show all 13 Subjects
Abstract:
... The present work aims to characterize and investigate the anti-inflammatory activity of hop extracts (cv. Cascade) in an in vitro model of gastric inflammation. The biological activities of hydroalcoholic and aqueous extracts from cones were evaluated by comparing IL-8 inhibition induced by TNFα. The hydroalcoholic extract demonstrated a higher inhibitory effect, which was just slightly affected b ...
DOI:
10.1016/j.jff.2019.03.041

19. Mediterranean, but not lacto-ovo-vegetarian, diet positively influence circulating progenitor cells for cardiovascular prevention: The CARDIVEG study

Author:
Cesari, F.; Dinu, M.; Pagliai, G.; Rogolino, A.; Giusti, B.; Gori, A.M.; Casini, A.; Marcucci, R.; Sofi, F.
Source:
Nutrition, metabolism, and cardiovascular diseases 2019 v.29 no.6 pp. 604-610
ISSN:
0939-4753
Subject:
interleukin-8,   etc   ; cardioprotective effect; chemokine CCL2; cross-over studies; eating habits; endothelial cells; geometry; interleukin-6; ovo-lacto vegetarian diet; risk profile; stem cells;     Show all 11 Subjects
Abstract:
... To evaluate the possible association between dietary habits and progenitor cells using data obtained from a randomized crossover trial using two different diets, lacto-ovo-vegetarian (VD) and Mediterranean (MD), the CARDIVEG study.Eighty clinically healthy subjects with a low-to-moderate cardiovascular risk profile (61 F; 19 M; mean age: 50.7 ± 11.6 years) were randomly assigned to isocaloric VD a ...
DOI:
10.1016/j.numecd.2019.02.005

20. Procyanidin B2 rich cocoa extracts inhibit inflammation in Caco-2 cell model of in vitro celiac disease by down-regulating interferon-gamma- or gliadin peptide 31-43-induced transglutaminase-2 and interleukin-15

Author:
Kramer, Kristen; Yeboah-Awudzi, Millicent; Magazine, Nicholas; King, Joan M.; Xu, Zhimin; Losso, Jack N.
Source:
Journal of functional foods 2019 v.57 pp. 112-120
ISSN:
1756-4646
Subject:
interleukin-8,   etc   ; biomarkers; caffeine; celiac disease; cysteamine; gliadin; human cell lines; inflammation; interferon-gamma; interleukin-15; interleukin-1beta; interleukin-6; models; procyanidins; secretion; theobromine;     Show all 16 Subjects
Abstract:
... The objective of this research was to investigate the efficacy of procyanidin B2 rich cocoa extracts on interferon-gamma (IFN-γ) or gliadin peptide p31-43-induced transglutaminase-2 and interleukin-15 (IL-15) in Caco-2 cell model of in vitro celiac disease. Cysteamine was used as a positive control inhibitor of TG2. Procyanidin B2-rich extract reduced IFN-γ- and gliadin p31-43-induced TG2 activity ...
DOI:
10.1016/j.jff.2019.03.039