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1. Immobilisation of CXCL8 gradients in microfluidic devices for migration experiments

Author:
Kilb, Michelle F.; Engemann, Victoria I.; Siddique, Asma; Stark, Robert W.; Schmitz, Katja
Source:
Colloids and surfaces 2021 v.198 pp. 111498
ISSN:
0927-7765
Subject:
interleukin-8,   etc   ; cell movement; chemotaxis; heparan sulfate;     Show all 4 Subjects
Abstract:
... The release of inflammatory chemokines leads to the formation of chemokine gradients that result in the directed migration of immune cells to the site of injury. In this process, cells respond to soluble gradients (chemotaxis) as well as to immobilised gradients (haptotaxis). Surface-bound chemokine gradients are mostly presented by endothelial cells and supported by glycosaminoglycans (GAGs), suc ...
DOI:
10.1016/j.colsurfb.2020.111498

2. Cytokine expression in the eye and brain of chickens following infection with a very virulent plus Marek’s disease virus strain

Author:
Salvador, Coral; Cortes, Aneg L.; Pandiri, Arun R.; Gimeno, Isabel M.
Source:
Veterinary immunology and immunopathology 2021 v.237 pp. 110277
ISSN:
0165-2427
Subject:
interleukin-8,   etc   ; brain; chickens; eyes; immunopathology; interleukin-15; interleukin-18; nervous system diseases; paralysis; pathogenesis; virulence;     Show all 11 Subjects
Abstract:
... Cytokine transcripts were evaluated chronologically in the brain and in the eye of chickens infected with the very virulent plus Marek’s disease virus (vv + MDV) strain 648A. Brain and eye samples were collected from chickens that were either suffering from transient paralysis (TP) (11 days post inoculation, dpi) or had completely recovered from TP but started developing clinical signs of persiste ...
DOI:
10.1016/j.vetimm.2021.110277

3. Mycobacterium tuberculosis stimulates IL-1β production by macrophages in an ESAT-6 dependent manner with the involvement of serum amyloid A3

Author:
Jung, Bock-Gie; Vankayalapati, Ramakrishna; Samten, Buka
Source:
Molecular immunology 2021 v.135 pp. 285-293
ISSN:
0161-5890
Subject:
interleukin-8,   etc   ; Mycobacterium tuberculosis; amyloid; blood serum; gene deletion; lungs; macrophages; mice; sequence analysis; tuberculosis;     Show all 10 Subjects
Abstract:
... Despite its critical roles in immune responses against tuberculosis infection and immune pathology, the molecular details of interleukin (IL)-1β production in tuberculosis infection remain elusive. To explore IL-1β production in tuberculosis infection, we infected mouse bone marrow-derived macrophages (BMDM) with Mycobacterium tuberculosis (Mtb) H37Rv, its early secreted antigenic target protein o ...
DOI:
10.1016/j.molimm.2021.04.022

4. PM2.5 collected using cyclonic separation causes stronger biological responses than that collected using a conventional filtration method

Author:
Honda, Akiko; Okuda, Tomoaki; Nagao, Megumi; Miyasaka, Natsuko; Tanaka, Michitaka; Takano, Hirohisa
Source:
Environmental research 2021 v.198 pp. 110490
ISSN:
0013-9351
Subject:
interleukin-8,   etc   ; aerodynamics; cyclone separators; epithelium; filtration; inflammation; interleukin-6; lungs; necrosis; neoplasms; particulates; research; secretion;     Show all 13 Subjects
Abstract:
... Evaluation of the health effects of particulate matter with aerodynamic dias. ≤ 2.5 μm (PM2.5) should reflect realistic condition in ambient atmosphere. However, using conventional filtration methods, only extracts from PM2.5 collected on the filter can be analyzed and not the particle itself. Cyclonic separation is a technique that enables the direct analysis of the effects of the crude “powder f ...
DOI:
10.1016/j.envres.2020.110490

5. The effect of lower airway inflammation on inflammatory cytokine gene expression in bronchoalveolar lavage fluid and whole blood in racing Thoroughbreds

Author:
Taylor, Sandra D.; Ivester, Kathleen M.; Stewart, Craig; Page, Allen E.; Horohov, David W.; Couetil, Laurent L.
Source:
Veterinary immunology and immunopathology 2021 v.237 pp. 110266
ISSN:
0165-2427
Subject:
interleukin-8,   etc   ; asthma; exercise; gene expression; immunopathology; inflammation; mast cells; neutrophils; observational studies; pathogenesis;     Show all 10 Subjects
Abstract:
... Immunological mechanisms involved in the pathogenesis of mild to moderate equine asthma (MEA) are not completely understood. There are limited data on bronchoalveolar lavage fluid (BALF) and blood inflammatory cytokine profiles in racehorses with MEA, and the effect of racing on inflammatory cytokines is unknown.We hypothesized that inflammatory cytokine gene expression in BALF and resting blood w ...
DOI:
10.1016/j.vetimm.2021.110266

6. Modulation of the inflammatory environment by spermatozoa through regulation of transforming growth factor beta in porcine uterine epithelial cells

Author:
Kim, Su-Jin; Hwangbo, Yong; Park, Choon-Keun
Source:
Reproductive Biology 2021 v.21 no.2 pp. 100484
ISSN:
1642-431X
Subject:
interleukin-8,   etc   ; boars; epithelium; gene expression; inflammation; interleukin-6; plasminogen; quantitative polymerase chain reaction; spermatozoa; uterus;     Show all 10 Subjects
Abstract:
... This study investigated the changes in the mRNA expression of transforming growth factor beta (TGF-β), plasminogen activators (PAs), and interleukin (IL) caused by sperm, as well as the regulatory mechanism of PA activity through TGF-β, in porcine uterine epithelial cells. The cells were isolated from the uterine horn of pig and co-incubated with Percoll-separated boar sperm (45% or 90%), or TGF-β ...
DOI:
10.1016/j.repbio.2021.100484

7. Proteasome subunit beta type-8 from sevenband grouper negatively regulates cytokine responses by interfering NF-κB signaling upon nervous necrosis viral infection

Author:
krishnan, Rahul; Kim, Jong-Oh; Jang, Yo-Seb; Oh, Myung-Joo
Source:
Fish & shellfish immunology 2021 v.113 pp. 118-124
ISSN:
1050-4648
Subject:
interleukin-8,   etc   ; cytopathogenicity; grouper; interferons; interleukin-6; necrosis; proteasome endopeptidase complex; shellfish; viral load; viruses;     Show all 10 Subjects
Abstract:
... During viral infection, proper regulation of immune signaling is essential to ensure successful clearance of virus. Immunoproteasome is constitutively expressed and gets induced during viral infection by interferon signaling and contributes to regulate proinflammatory cytokine production and activation of the NF-κB pathway. In this study, we identified Hs-PSMB8, a member of the proteasome β-subuni ...
DOI:
10.1016/j.fsi.2021.04.004

8. IL- 1β induces expression of proinflammatory cytokines and migration of human colon cancer cells through upregulation of SIRT1

Author:
Jung, Jaekyung; Lee, Yeon-Hwa; Fang, Xizhu; Kim, Su-Jung; Kim, Seong Hoon; Kim, Do-Hee; Song, Na-Young; Na, Hye-Kyung; Baek, Jeong-Heum; Surh, Young-Joon
Source:
Archives of biochemistry and biophysics 2021 v.703 pp. 108847
ISSN:
0003-9861
Subject:
interleukin-8,   etc   ; biophysics; cell senescence; colorectal neoplasms; humans; interleukin-6; low calorie diet; phosphorylation; protein synthesis;     Show all 9 Subjects
Abstract:
... SIRT1 is a mammalian NAD⁺-dependent deacetylase, which is known to be involved in various physiological events, such as adaptive response to environmental stresses including caloric restriction, as well as in aging and cellular senescence. However, recent studies have revealed overexpression of SIRT1 in many different types of human malignancies, particularly colon cancer. Interleukin-1β (IL-1β) i ...
DOI:
10.1016/j.abb.2021.108847

9. The NR4A agonist, Cytosporone B, attenuates pro-inflammatory mediators in human colorectal cancer tissue ex vivo

Author:
Ismaiel, Mohamed; Murphy, Brenda; Aldhafiri, Sarah; Giffney, Hugh E.; Thornton, Kevin; Mukhopadhya, Anindya; Keogh, Ciara E.; Fattah, Sarinj; Mohan, Helen M.; Cummins, Eoin P.; Murphy, Evelyn P.; Winter, Des C.; Crean, Daniel
Source:
Biochemical and biophysical research communications 2021 v.554 pp. 179-185
ISSN:
0006-291X
Subject:
interleukin-8,   etc   ; agonists; colon; colorectal neoplasms; disease progression; electrical resistance; histology; humans; inflammation; research;     Show all 10 Subjects
Abstract:
... Inflammation is a pivotal pathological factor in colorectal cancer (CRC) initiation and progression, and modulating this inflammatory state has the potential to ameliorate disease progression. NR4A receptors have emerged as key regulators of inflammatory pathways that are important in CRC. Here, we have examined the effect of NR4A agonist, Cytosporone B (CsnB), on colorectal tissue integrity and i ...
DOI:
10.1016/j.bbrc.2021.03.110

10. Insight into chitosan/zeolite-A nanocomposite as an advanced carrier for levofloxacin and its anti-inflammatory properties; loading, release, and anti-inflammatory studies

Author:
Mostafa, Merna; El-Meligy, Mohammed A.; Sharaf, Mohamed; Soliman, Ahmed T.; AbuKhadra, Mostafa R.
Source:
International journal of biological macromolecules 2021 v.179 pp. 206-216
ISSN:
0141-8130
Subject:
interleukin-8,   etc   ; anti-inflammatory activity; chitosan; cytotoxicity; energy; heat production; humans; interleukin-6; levofloxacin; nanocomposites;     Show all 10 Subjects
Abstract:
... Chitosan/zeolite-A nanocomposite (CH/ZA) was synthesized as a potential carrier for levofloxacin (LVOX) of enhanced technical properties. The CH/ZA composite displayed enhanced loading capacity (425 mg/g) as compared to chitosan (188.8 mg/g) and zeolite-A (234.6 mg/g). The loading behavior follows Pseudo-Second-order and Langmuir as kinetic and isotherm models. The equilibrium studies, Gaussian en ...
DOI:
10.1016/j.ijbiomac.2021.02.201

11. Immunohistochemical Expression of Neurokinin-A and Interleukin-8 in the Bronchial Epithelium of Horses with Severe Equine Asthma Syndrome during Asymptomatic, Exacerbation, and Remission Phase

Author:
Morini, Maria; Peli, Angelo; Rinnovati, Riccardo; Magazzù, Giuseppe; Romagnoli, Noemi; Spadari, Alessandro; Pietra, Marco
Source:
Animals 2021 v.11 no.5
ISSN:
2076-2615
Subject:
interleukin-8,   etc   ; adults; asthma; biopsy; bronchi; bronchoscopy; disease diagnosis; epithelium; horses; immunohistochemistry; inflammation; remission;     Show all 12 Subjects
Abstract:
... Severe equine asthma (EA) syndrome is a chronic obstructive disease characterized by exaggerated contraction, inflammation, and structural alteration of the airways in adult horses, when exposed to airborne molds and particulate material. However, little is known about the relationship between the degree and type of inflammation on one hand, and the severity of the disease and the response to trea ...
DOI:
10.3390/ani11051376

12. Sea Urchin Pigments: Echinochrome A and Its Potential Implication in the Cytokine Storm Syndrome

Author:
Rubilar, Tamara; Barbieri, Elena S.; Gazquez, Ayelén; Avaro, Marisa
Source:
Marine drugs 2021 v.19 no.5
ISSN:
1660-3397
Subject:
interleukin-8,   etc   ; Echinoidea; blood flow; drugs; glaucoma; glutathione; interleukin-6; lipid peroxidation; mitochondria;     Show all 9 Subjects
Abstract:
... Background: Echinochrome A (EchA) is a pigment from sea urchins. EchA is a polyhydroxylated 1,4-naphthoquinone that contains several hydroxyl groups appropriate for free-radical scavenging and preventing redox imbalance. EchA is the most studied molecule of this family and is an active principle approved to be used in humans, usually for cardiopathies and glaucoma. EchA is used as a pharmaceutical ...
DOI:
10.3390/md19050267

13. Association of Obesity with Depressive Symptomatology, Eating Habits, Interleukin-8 and Cortisol in a Young Population

Author:
López-Pulido, Edgar Iván; Ramírez-De Los Santos, Saúl; González-Sánchez, Grecia Denisse; Becerra-Ruiz, Julieta Saraí; Rivas-Delgado, Mariana Elizabeth; Becerra-Hurtado, Jessica; Ramírez-De Los Santos, María Luisa; Alonso-Sánchez, Carmen Celina; González-Silva, Napoleón; Guzmán-Flores, Juan Manuel
Source:
Ecology of food and nutrition 2021 v.60 no.3 pp. 324-333
ISSN:
1543-5237
Subject:
interleukin-8,   etc   ; adiposity; blood sampling; cortisol; cross-sectional studies; ecology; glucose; lipid composition; nutrition; obesity;     Show all 10 Subjects
Abstract:
... Obesity is the result of a complex combination of psychological, biological, and environmental factors. In this work, we evaluate whether obesity is related to eating habits, depressive symptomatology, as well as interleukin-8 and cortisol. A descriptive cross-sectional study was carried out in 232 university students. All youths were surveyed to determine their eating habits and depressive sympto ...
DOI:
10.1080/03670244.2020.1845166

14. Immunological components and antioxidant activity in human milk processed by different high pressure-thermal treatments at low initial temperature and flash holding times

Author:
Ramírez, Rosario; Garrido, María; Rocha-Pimienta, Javier; García-Parra, Jesús; Delgado-Adámez, Jonathan
Source:
Food chemistry 2021 v.343 pp. 128546
ISSN:
0308-8146
Subject:
interleukin-8,   etc   ; antioxidant activity; breast milk; food chemistry; immunoglobulins; interleukin-10; interleukin-6; pressure; temperature;     Show all 9 Subjects
Abstract:
... The effect of high pressure thermal (HPT) processing on the immunoglobulin (IgM, IgA and IgG), and cytokine content (IL-6, IL-8, IL-10, and TNF-α), and antioxidant activity of human milk was analyzed after the application of different treatments between 200, and 800 MPa at low initial temperatures (between −15, and 50 °C) and for 1 s (flash treatments). Low pressures intensities did not induce cha ...
DOI:
10.1016/j.foodchem.2020.128546

15. Outer membrane vesicles derived from hypervirulent Klebsiella pneumoniae stimulate the inflammatory response

Author:
Zhang, Jing; Zhao, Jinxin; Li, Jiaxi; Xia, Yun; Cao, Ju
Source:
Microbial pathogenesis 2021 v.154 pp. 104841
ISSN:
0882-4010
Subject:
interleukin-8,   etc   ; Klebsiella pneumoniae; cytotoxicity; innate immunity; interleukin-6; liver; pathogenesis; pathotypes; proteomics; ultracentrifugation;     Show all 10 Subjects
Abstract:
... Hypervirulent Klebsiella pneumoniae (hvKP), an increasing important pathotype, was initially recognized as a cause of severe liver abscesses and subsequently as a cause of other complications posing a clinical threat. Outer membrane vesicles (OMVs) secreted from abundant gram-negative bacteria are considered an important vehicle for delivery of effector molecules to target cells. However, the prod ...
DOI:
10.1016/j.micpath.2021.104841

16. Tanshinone IIA exhibits anti-inflammatory and antioxidative effects in LPS-stimulated bovine endometrial epithelial cells by activating the Nrf2 signaling pathway

Author:
Fu, Kaiqiang; Feng, Chao; Shao, Lingzhen; Mei, Lian; Cao, Rongfeng
Source:
Research in veterinary science 2021 v.136 pp. 220-226
ISSN:
0034-5288
Subject:
interleukin-8,   etc   ; ; Salvia miltiorrhiza; cattle; endometritis; endometrium; epithelium; gene expression; inflammation; interleukin-6; research; veterinary medicine;     Show all 12 Subjects
Abstract:
... Endometritis is a major disease in productive bovines, and is also caused by conditional pathogens after delivery. The integrity and activity of bovine endometrial epithelial cells (bEECs) determine the development of endometritis. Tanshinone IIA, a compound purified from Salvia miltiorrhiza bunge, has been reported to have anti-inflammatory effects. The aim of this study was to investigate the an ...
DOI:
10.1016/j.rvsc.2021.03.004

17. The Autocatalytic Cleavage Domain Is Not Required for the Activity of ScpC, a Virulence Protease from Streptococcus pyogenes: A Structural Insight

Author:
Jobichen, Chacko; Ying Chong, Tan; Hui Ling, Tai; Sivaraman, J.
Source:
Biochemistry 2021 v.60 no.19 pp. 1564-1568
ISSN:
1520-4995
Subject:
interleukin-8,   etc   ; Streptococcus pyogenes; crystal structure; humans; mutants; neutrophils; pathogens; polypeptides; proteolysis; serine proteinases; vaccines; virulence;     Show all 12 Subjects
Abstract:
... Group A Streptococcus (GAS, or Streptococcus pyogenes) is a leading human bacterial pathogen with diverse clinical manifestations, ranging from mild to life-threatening and to severe immune sequela. These diseases, combined, account for more than half a million deaths per year, globally. To accomplish its vast pathogenic potential, GAS expresses a multitude of virulent proteins, including the pivo ...
DOI:
10.1021/acs.biochem.1c00185

18. Biological characteristic and cytokines response of passages duck plague virus in ducks

Author:
Niu, Yinjie; Su, Shibo; Chen, Xiaohan; Zhao, Lili; Chen, Hongyan
Source:
Virus research 2021 v.295 pp. 198320
ISSN:
0168-1702
Subject:
interleukin-8,   etc   ; ; Anatid alphaherpesvirus 1; ducks; fibroblasts; interleukin-1; interleukin-2; mortality; research; virulence; viruses;     Show all 11 Subjects
Abstract:
... To better understand the pathogenicity of duck plague virus (DPV). The DPV Chinese standard challenge strain (DPV CSC) was continuously passaged 20 times in duck embryo fibroblasts (DEFs). DPV F1 was lethal for 2-week-ducks, but DPV F10 and F20 were not lethal for 2-week ducks, the 528 bp in UL2 region of DPV F1-F20 was deleted, which suggested that the deletion in UL2 region was not related with ...
DOI:
10.1016/j.virusres.2021.198320

19. Dydrogesterone Affects the Transcription of Genes in Innate Immune and Coagulation Cascade in Zebrafish Embryos

Author:
Shi, Wen-Jun; Liang, Yan‑Qiu; Zhao, Jian‑Liang; Hu, Li‑Xin; Huang, Guo-Yong; Ying, Guang-Guo
Source:
Bulletin of environmental contamination and toxicology 2021 v.106 no.4 pp. 594-599
ISSN:
0007-4861
Subject:
interleukin-8,   etc   ; ; Danio rerio; animal growth; coagulation; innate immunity; pollution; reproduction; toxicology;     Show all 9 Subjects
Abstract:
... Dydrogesterone (DDG) acts on the reproduction but also affects the functioning of non-reproductive system. So far, the knowledge about other effects of DDG remains limited. Here we investigated the effects of DDG on the transcription of genes in innate immune and coagulation cascade in zebrafish embryos. The zebrafish embryos were exposed to DDG at 49.0, 527 and 5890 ng L⁻ ¹ for 144 hour post fert ...
DOI:
10.1007/s00128-021-03127-5

20. Enhanced immersion vaccination through hyperosmotic treatment in the largemouth bass (Micropterus salmoides)

Author:
Wu, Ronghua; Chi, Yuyu; Yu, Jiaqian; Ni, Chang; Yao, Jiayun
Source:
Aquaculture 2021 v.535 pp. 736371
ISSN:
0044-8486
Subject:
interleukin-8,   etc   ; ; Aeromonas veronii; Micropterus salmoides; antibodies; aquaculture; blood serum; fish; freshwater; lysozyme; myeloperoxidase; salinity; vaccination;     Show all 13 Subjects
Abstract:
... This study aims to evaluate the effects of immersion vaccination through hyperosmotic treatment, and determine the optimum hyperosmotic salinity for largemouth bass (Micropterus salmoides) by determining immune responses and protective efficacies post vaccination. For hyperosmotic immersion (HI), M. salmoides were immersed in three hyperosmotic salinities (5, 10 and 20‰ salinity) respectively, the ...
DOI:
10.1016/j.aquaculture.2021.736371