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1. Impacts of polystyrene nanoplastics at the environmentally relevant and sub-lethal concentrations on the oxidative stress, immune responses, and gut microbiota to grass carp (Ctenopharyngodon idella)

Author:
Zhen Li; Lei Yan; Muhammad Junaid; Xikun Chen; Hongping Liao; Dandan Gao; Qiuping Wang; Yanling Zhang; Jun Wang
Source:
Journal of hazardous materials 2023 v.441 pp. 129995
ISSN:
0304-3894
Subject:
intestinal mucosa,   etc   ; Ctenopharyngodon idella; Proteobacteria; community structure; exposure duration; fish; freshwater; homeostasis; human health; immune response; inflammation; interleukin-10; interleukin-6; interleukin-8; intestinal microorganisms; microbial communities; nanoplastics; oxidative stress; pollution; polystyrenes; toxicity;     Show all 21 Subjects
Abstract:
... Nanoplastics (NPs) are emerging environmental contaminants with alarming ecological and human health concerns due to their unique physicochemical properties. This study elucidates the impacts of environmentally relevant concentrations (ERCs, 300 and 3000 ng/L) and sublethal concentrations (SLCs, 300 and 3000 μg/L) of polystyrene nanoplastics (PS-NPs, size 80 nm) on the intestinal immune response a ...
DOI:
10.1016/j.jhazmat.2022.129995

2. From Intestinal Epithelial Homeostasis to Colorectal Cancer: Autophagy Regulation in Cellular Stress

Author:
Qiuluo Liu; Yan Chen; Li Zhou; Haining Chen; Zongguang Zhou
Source:
Antioxidants 2022 v.11 no.7 pp. -
ISSN:
2076-3921
Subject:
intestinal mucosa,   etc   ; autophagy; colorectal neoplasms; homeostasis; therapeutics;     Show all 5 Subjects
Abstract:
... The intestinal epithelium is continuously exposed to abundant stress stimuli, which relies on an evolutionarily conserved process, autophagy, to maintain its homeostasis by degrading and recycling unwanted and damaged intracellular substances. Otherwise, disruption of this balance will result in the development of a wide range of disorders, including colorectal cancer (CRC). Dysregulated autophagy ...
DOI:
10.3390/antiox11071308

3. Modulation of designer biomimetic matrices for optimized differentiated intestinal epithelial cultures

Author:
Wang Xi; Jad Saleh; Ayako Yamada; Caterina Tomba; Barbara Mercier; Sébastien Janel; Tien Dang; Matis Soleilhac; Aurélie Djemat; Huiqiong Wu; Béatrice Romagnolo; Frank Lafont; René-Marc Mège; Yong Chen; Delphine Delacour
Source:
Biomaterials 2022 v.282 pp. 121380
ISSN:
0142-9612
Subject:
intestinal mucosa,   etc   ; biocompatible materials; biomimetics; hydrogels; mice; organoids; phenotype;     Show all 7 Subjects
Abstract:
... The field of intestinal biology is thirstily searching for different culture methods that complement the limitations of organoids, particularly the lack of a differentiated intestinal compartment. While being recognized as an important milestone for basic and translational biological studies, many primary cultures of intestinal epithelium (IE) rely on empirical trials using hydrogels of various st ...
DOI:
10.1016/j.biomaterials.2022.121380

4. Tea Polyphenols: A Natural Antioxidant Regulates Gut Flora to Protect the Intestinal Mucosa and Prevent Chronic Diseases

Author:
Xinzhou Wang; Yanan Liu; Zufang Wu; Peng Zhang; Xin Zhang
Source:
Antioxidants 2022 v.11 no.2 pp. -
ISSN:
2076-3921
Subject:
intestinal mucosa,   etc   ; antioxidants; humans; intestinal microorganisms; polyphenols; tea; therapeutics;     Show all 7 Subjects
Abstract:
... The intestinal tract of a healthy human body hosts many microorganisms that are closely linked to all aspects of people’s lives. The impact of intestinal flora on host health is no longer limited to the gut but can also affect every organ in the body through various pathways. Studies have found that intestinal flora can be altered by external factors, which provides new ideas for treating some dis ...
DOI:
10.3390/antiox11020253

5. Aluminum induced intestinal dysfunction via mechanical, immune, chemical and biological barriers

Author:
Wudi Hao; Chenyu Hao; Chengrong Wu; Yuqing Xu; Cuihong Jin
Source:
Chemosphere 2022 v.288 pp. 132556
ISSN:
0045-6535
Subject:
intestinal mucosa,   etc   ; aluminum; apoptosis; digestive tract; intestinal microorganisms; permeability;     Show all 6 Subjects
Abstract:
... Aluminum is the most abundant metal element in the Earth's crust, which exists naturally in the form of aluminum compounds. Aluminum is mainly absorbed through the gastrointestinal tract, which varies with different aluminum compounds. During this process, aluminum could induce the disruption of intestinal mucosa barrier. However, its underlying mechanism has not been elucidated yet. Previous stud ...
DOI:
10.1016/j.chemosphere.2021.132556

6. Thyroid hormone signaling in the intestinal stem cells and their niche

Author:
Maria Virginia Giolito; Michelina Plateroti
Source:
Cellular and molecular life sciences 2022 v.79 no.9 pp. 476
ISSN:
1420-682X
Subject:
intestinal mucosa,   etc   ; amphibians; hormone receptors; metamorphosis; stem cells; thyroid hormones;     Show all 6 Subjects
Abstract:
... Several studies emphasized the function of the thyroid hormones in stem cell biology. These hormones act through the nuclear hormone receptor TRs, which are T3-modulated transcription factors. Pioneer work on T3-dependent amphibian metamorphosis showed that the crosstalk between the epithelium and the underlying mesenchyme is absolutely required for intestinal maturation and stem cell emergence. W ...
DOI:
10.1007/s00018-022-04503-y

7. Distribution of intraepithelial lymphocytes, mast cells, and goblet cells in the intestine of alpaca

Author:
Meng Ma; Xue Bai; Zixu Wang; Yulan Dong; Yaoxing Chen; Jing Cao
Source:
Anatomia, histologia, embryologia 2022 v.51 no.4 pp. 501-508
ISSN:
0340-2096
Subject:
intestinal mucosa,   etc   ; alpacas; colon; cytoplasm; ileum; immunohistochemistry; mucosal immunity; serosa;     Show all 8 Subjects
Abstract:
... Intestinal diseases in ruminants are frequent and susceptible to invasion by exogenous substances, and the intestinal mucosal barrier is the first line of defence of the body's immune defence. At present, the study on the structure of intestinal mucosal immune barrier in alpaca is incomplete. Therefore, the alpaca intestines were studied to show the distribution characteristics of intestinal mucos ...
DOI:
10.1111/ahe.12823

8. Hepatic portal venous gas associated with rapid infusion of postoperative early enteral nutrition after radical total gastrectomy

Author:
Shengbo Sun; Xiangyun Zheng; Huanhu Zhang; Chuanji Han; Guowei Zhao
Source:
Nutrition 2022 v.101 pp. 111685
ISSN:
0899-9007
Subject:
intestinal mucosa,   etc   ; enteral feeding; hospitals; laparotomy; patients; stomach neoplasms; women;     Show all 7 Subjects
Abstract:
... Hepatic portal venous gas (HPVG) is a rare and severe imaging manifestation for surgeons, and it may require emergency surgery. We report an unusual case of HPVG in association with the drip rate of enteral nutrition (EN) after laparoscopic-assisted radical total gastrectomy with Roux-en-Y reconstruction. A 66-year-old woman with gastric cancer was admitted to our hospital. She was diagnosed with ...
DOI:
10.1016/j.nut.2022.111685

9. The Impact of Short-Chain Fatty Acids on Neonatal Regulatory T Cells

Author:
Jessica Chun; Gergely Toldi
Source:
Nutrients 2022 v.14 no.18 pp. -
ISSN:
2072-6643
Subject:
intestinal mucosa,   etc   ; adaptive immunity; digestive tract; immune system; metabolism; microbial colonization;     Show all 6 Subjects
Abstract:
... Over the first weeks of life, the neonatal gastrointestinal tract is rapidly colonised by a diverse range of microbial species that come to form the ‘gut microbiota’. Microbial colonisation of the neonatal gut is a well-established regulator of several physiological processes that contribute to immunological protection in postnatal life, including the development of the intestinal mucosa and adapt ...
DOI:
10.3390/nu14183670

10. Surviving in the fish gut: Comparative inhibitory capacities against the host proteinases in cestodes of the genus Proteocephalus

Author:
Galina I. Izvekova; Tatyana V. Frolova; Evgeny I. Izvekov; Alexander E. Zhokhov
Source:
Journal of fish diseases 2022 v.45 no.7 pp. 1011-1021
ISSN:
0140-7775
Subject:
intestinal mucosa,   etc   ; Gymnocephalus cernua; Proteocephalus; fish; polyacrylamide gel electrophoresis; proteolysis; tapeworms; trypsin;     Show all 8 Subjects
Abstract:
... Currently, little is known about inhibitory substances enabling tapeworms to settle in fish intestines thereby avoiding proteolysis. Contrary to previous studies with certain host–parasite pairs, this research compares the inhibitory capacities in three tapeworm species of the same genus Proteocephalus from four different fishes (P. torulosus from dace and zope, P. sagittus from stone loach and P. ...
DOI:
10.1111/jfd.13624

11. Efficacy of clofazimine and nitazoxanide combination in treating intestinal cryptosporidiosis and enhancing intestinal cellular regeneration in immunocompromised mice

Author:
Marwa Esmat; Amany A. Abdel-Aal; Maisa A. Shalaby; Manal Badawi; Hala Elaskary; Ahmed Badawi Yousif; Mennat-Elrahman A. Fahmy
Source:
Food and Waterborne Parasitology 2022 v.27 pp. e00161
ISSN:
2405-6766
Subject:
intestinal mucosa,   etc   ; Cryptosporidium; Protozoa; cryptosporidiosis; drugs; leprosy; mice; microvilli; mitochondria; oocysts; parasites; parasitology;     Show all 12 Subjects
Abstract:
... Cryptosporidium is a widely distributed food and water-borne enteric protozoan that affects a wide range of vertebrates, resulting in life-threatening consequences, particularly in immunocompromised hosts. The lack of effective anti-cryptosporidial drugs may be related to the parasite's unique intestinal location, plus the lack of studies on the process by which the protozoan is able to impair int ...
DOI:
10.1016/j.fawpar.2022.e00161

12. Emerging technologies to increase gastrointestinal transit times of drug delivery systems

Author:
Gergely Kali; Patrick Knoll; Andreas Bernkop-Schnürch
Source:
Journal of controlled release 2022 v.346 pp. 289-299
ISSN:
0168-3659
Subject:
intestinal mucosa,   etc   ; bioadhesives; cyclodextrins; drugs; gastrointestinal transit; gels; glycoproteins; mucus; nanocarriers; pylorus; zeta potential;     Show all 11 Subjects
Abstract:
... Apart from already established technologies to increase gastrointestinal transit times, including devices rapidly increasing in size once they have reached the stomach in order to retard the passage through the pylorus, formulations that float on gastric fluids and mucoadhesive drug delivery systems adhering to the gastrointestinal mucosa, there are new technologies emerging that might be game cha ...
DOI:
10.1016/j.jconrel.2022.04.016

13. Polyaminated pullulan, a new biodegradable and cationic pullulan derivative for mucosal drug delivery

Author:
Nguyet-Minh Nguyen Le; Bao Le-Vinh; Julian David Friedl; Aamir Jalil; Gergely Kali; Andreas Bernkop-Schnürch
Source:
Carbohydrate polymers 2022 v.282 pp. 119143
ISSN:
0144-8617
Subject:
intestinal mucosa,   etc   ; bioadhesives; biodegradability; chlorides; drugs; mucoadhesion; mucus; pH; polyamines; pullulan; tensile strength; viscosity;     Show all 12 Subjects
Abstract:
... To prepare new polycationic pullulan derivatives exhibiting highly mucoadhesive and sustained drug release properties. Hydroxy groups of pullulan were activated with mesyl chloride followed by conjugation with low-molecular weight polyamines. Pullulan-tris(2-aminoethyl)amine (Pul-TAEA) and pullulan-polyethyleneimine (Pul-PEI) were evaluated regarding swelling behaviour, mucoadhesive properties and ...
DOI:
10.1016/j.carbpol.2022.119143

14. Intervention and potential mechanism of non-starch polysaccharides from natural resources on ulcerative colitis: A review

Author:
Yu-Jing Wang; Qiang-Ming Li; Xue-Qiang Zha; Jian-Ping Luo
Source:
International journal of biological macromolecules 2022 v.210 pp. 545-564
ISSN:
0141-8130
Subject:
intestinal mucosa,   etc   ; colon; etiology; immune response; intestinal microorganisms; metabolites; pathogenesis; polysaccharides; rectum; therapeutics; ulcerative colitis;     Show all 11 Subjects
Abstract:
... Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology that affects the colon and rectum. It has evolved into a global burden due to the high incidence in developed countries and the highly-increased incidence in developing countries. Non-starch polysaccharides (NSPs) from natural resources, as a type of functional carbohydrates, have a significant therapeutic effect o ...
DOI:
10.1016/j.ijbiomac.2022.04.208

15. Tannic Acid Extracted from Galla chinensis Supplementation in the Diet Improves Intestinal Development through Suppressing Inflammatory Responses via Blockage of NF-κB in Broiler Chickens

Author:
Changwei Jing; Jiaxing Niu; Yang Liu; Ning Jiao; Libo Huang; Shuzhen Jiang; Lei Yan; Weiren Yang; Yang Li
Source:
Animals 2022 v.12 no.18 pp. -
ISSN:
2076-2615
Subject:
intestinal mucosa,   etc   ; blood serum; cytokines; dietary supplements; gene expression; microencapsulation; poultry industry; tannins; tight junctions;     Show all 9 Subjects
Abstract:
... The objective of this study was to investigate the effects of adding tannic acid (TA) extracted from Galla chinensis to the diet of broiler chickens on intestinal development. A total of 324 healthy 1-day-old broilers were used in a 42 d study, and divided into two treatment groups at random (six replicates per group). Broilers were either received a basal diet or a basal diet supplemented with 30 ...
DOI:
10.3390/ani12182397

16. Implications of microbe-mediated crosstalk in the gut: Impact on metabolic diseases

Author:
Roofia Beg; Katja Gonzalez; Kristina Martinez-Guryn
Source:
Biochimica et biophysica acta 2022 v.1867 no.8 pp. 159180
ISSN:
1388-1981
Subject:
intestinal mucosa,   etc   ; cardiovascular diseases; fatty liver; intestinal microorganisms; lipid metabolism; noninsulin-dependent diabetes mellitus; obesity;     Show all 7 Subjects
Abstract:
... Metabolic diseases continue to afflict most of the U.S. population. Advancements in gut microbiota research have led to the discovery of various functional roles of microorganisms that influence the development of obesity and co-morbidities including type 2 diabetes, non-alcoholic fatty liver disease and cardiovascular disease. Many mechanisms behind these host-microbe interactions stem from proce ...
DOI:
10.1016/j.bbalip.2022.159180

17. A retrospective study on Schistosoma spindale infection in domestic ruminants, Andhra Pradesh, India

Author:
Ch. Jyothi Sree; V. Samatha; C. Sreedevi; V. Rama Devi
Source:
Journal of parasitic diseases 2022 v.46 no.3 pp. 869-875
ISSN:
0971-7196
Subject:
intestinal mucosa,   etc   ; Schistosoma spindale; adults; eosinophils; fibroblasts; granuloma; histology; microscopy; necropsy; retrospective studies; sheep; India;     Show all 12 Subjects
Abstract:
... The present study was undertaken to determine the prevalence of Schistosoma spindale infection in domestic ruminants in Krishna district, Andhra Pradesh by coprological and necropsy examination. Examination of 177 buffaloes, 283 sheep and 166 goats faecal samples (n = 626) revealed 2.25, 2.82 and 1.80% of S. spindale infection, respectively. Necropsy examination of 21 buffaloes, 185 sheep and 217 ...
DOI:
10.1007/s12639-022-01504-3

18. Research note: effects of different anticoccidial regimens on the growth performance, hematological parameters, immune response, and intestinal coccidial lesion scores of yellow-feathered broilers

Author:
Ting Lei; Dawei Wu; Zheng Song; Yu Ren; Qiang Yu; Changxue Qi; Pan Xiao; Jun Gong
Source:
Poultry science 2022 v.101 no.10 pp. 102019
ISSN:
0032-5791
Subject:
intestinal mucosa,   etc   ; blood; coccidiosis; coccidiostats; diet; feeds; females; growth performance; immune response; narasin; salinomycin; urine; vaccines;     Show all 13 Subjects
Abstract:
... Yellow-feathered broiler chickens generally have a longer growth cycle than white broilers and therefore face different coccidiosis challenges. General single vaccine and drug regimens struggle to prevent coccidiosis for yellow broilers. In this study, a single vaccine, and a combination of coccidiostat regimens was employed to explore the preventative and control effects of different pilot regime ...
DOI:
10.1016/j.psj.2022.102019

19. 4-hydroxy-2-alkenals in foods: a review on risk assessment, analytical methods, formation, occurrence, mitigation and future challenges

Author:
Tânia Gonçalves Albuquerque; Helena S. Costa; M. Beatriz P. P. Oliveira
Source:
Critical reviews in food science and nutrition 2022 v.62 no.13 pp. 3569-3597
ISSN:
1549-7852
Subject:
intestinal mucosa,   etc   ; colon; exposure assessment; food science; human health; nutrition; oxidation; risk; temperature; toxicity; vitamin E;     Show all 11 Subjects
Abstract:
... Undoubtedly, significant advances were performed concerning 4-hydroxy-2-alkenals research on foods, and their formation by double oxidation of polyunsaturated fatty acids. But further studies are still needed, especially on their occurrence in foods enriched with n-3 and n-6 fatty acids, as well as in foods for infants and processed foods. Major factors concerning the formation of 4-hydroxy-2-alke ...
DOI:
10.1080/10408398.2020.1867499

20. Precision of cyathostomin luminal worm counts: Investigation of storage duration and fixative

Author:
Mackenzie A. Smith; Alyssa B. Carpenter; Martin K. Nielsen
Source:
Veterinary parasitology 2022 v.309 pp. 109773
ISSN:
0304-4017
Subject:
intestinal mucosa,   etc   ; Cyathostominae; adults; cecum; colon; ethanol; euthanasia; formalin; horses; larvae; necropsy; storage time; veterinary parasitology;     Show all 13 Subjects
Abstract:
... Essentially all grazing horses are infected with cyathostomin parasites. Adult cyathostomins reside in the large intestine of the horse and larval stages encyst within intestinal mucosa. Manual worm collection from aliquots of intestinal content is the current gold standard for retrieval and enumeration of luminal parasites, however, no research has been conducted to standardize specific parameter ...
DOI:
10.1016/j.vetpar.2022.109773