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1. Akirin2 plays an important role in protecting Megalobrama amblycephala from Aeromonas hydrophila infection

Author:
Shujuan Wang; Zhipeng Tai; Qianhui Sun; Jixiu Wang; Huanling Wang; Zexia Gao; Hong Liu
Source:
Aquaculture 2023 v.562 pp. 738836
ISSN:
0044-8486
Subject:
intraperitoneal injection,   etc   ; Aeromonas hydrophila; Drosophila; Megalobrama amblycephala; antimicrobial peptides; aquaculture; fish; gene expression; glutathione transferase; immunity; liver; luciferase; protective effect; quantitative polymerase chain reaction; spleen;     Show all 15 Subjects
Abstract:
... Akirins are highly conserved, small, nuclear proteins that have been recognized as key regulators of multiple gene expression patterns and play important roles in immune responses. Previous studies on Akirins have mainly focused on the model species Drosophila and mice, while there have been few studies on fish. In the present study, two Akirin genes, Akirin1 and Akirin2, were identified from Mega ...
DOI:
10.1016/j.aquaculture.2022.738836

2. Determining transcriptomic response of kidneys of olive flounder to viral hemorrhagic septicemia virus infection using next-generation sequencing

Author:
Hyoung Jun Kim; Jeong Su Park; Se Ryun Kwon; Youngjin Park
Source:
Aquaculture 2023 v.562 pp. 738886
ISSN:
0044-8486
Subject:
intraperitoneal injection,   etc   ; Paralichthys olivaceus; RNA; Viral hemorrhagic septicemia virus; aquaculture; aquaculture industry; chemokines; flounder; gene expression regulation; interleukins; kidneys; metabolism; septicemia; tissue culture; transcriptomics; Korean Peninsula;     Show all 16 Subjects
Abstract:
... Viral hemorrhagic septicemia (VHS) in olive flounder (Paralichthys olivaceus) causes considerable economic losses in the flounder aquaculture industry in Korea. This study was aimed to identify the immune-associated genes contributing to VHSV infection progression in the kidneys of the olive flounder. Ten fish were divided into two groups via an intraperitoneal injection with either diethylpyrocar ...
DOI:
10.1016/j.aquaculture.2022.738886

3. Pathogenic infection and microbial composition of yellow catfish (Pelteobagrus fulvidraco) challenged by Aeromonas veronii and Proteus mirabilis

Author:
Wanying Zhai; Qian Wang; Xinpeng Zhu; Xiaoying Jia; Liangbiao Chen
Source:
Aquaculture and fisheries 2023 v.8 no.2 pp. 166-173
ISSN:
2468-550X
Subject:
intraperitoneal injection,   etc   ; Aeromonas veronii; Danio rerio; Ictalurus punctatus; Moraxella; Proteus mirabilis; Tachysurus fulvidraco; Vibrio; bacterial communities; catfish; disease prevention; freshwater fish; microbiome; mortality; mucus; pathogenicity; China;     Show all 17 Subjects
Abstract:
... The catfishes are a group of economically important freshwater fish in China, which in recent years have suffered heavy losses as a result of bacterial outbreaks. In this study, we examined the diversity of the microbiome of infected skin mucus of yellow catfish (Pelteobagrus fulvidraco) and channel catfish (Ictalurus punctatus) and analyzed the bacterial pathogens. We found several common pathoge ...
DOI:
10.1016/j.aaf.2021.05.007

4. Analgesic grayanoids from Craibiodendron henryi

Author:
Shu-Meng Xiao; Yun-Bao Liu; Jing Qu; Shuang-Gang Ma; Yong Li; Shi-Shan Yu
Source:
Tetrahedron 2022 v.120 pp. 132892
ISSN:
0040-4020
Subject:
intraperitoneal injection,   etc   ; Craibiodendron; analgesic effect; diterpenoids; morphine; spectroscopy;     Show all 6 Subjects
Abstract:
... Fourteen new grayanane-type diterpenes, and a known diterpene, 14β-O-(2S,3S-nilyl)-2α,3β,5β,6β,16α-pentahydroxygrayanane, were isolated from twigs of Craibiodendron henryi W. W. Smith. The structures of the new compounds were confirmed by extensive spectroscopy. The analgesic activities of Compounds 1–14 were evaluated by performing an acetic-acid-induced writhing test on mice. Compounds 1–5 and 9 ...
DOI:
10.1016/j.tet.2022.132892

5. The pattern of hippocampal neuronal, LTP and unilateral labyrinthectomy in male rats: the role of exercise and curcumin

Author:
N. Khalaji; G. Aminpour; B. Pourheydar; N. Abdollahzade; H. Parsaie; L. Derafshpour
Source:
Comparative exercise physiology 2022 v.18 no.4 pp. 311-318
ISSN:
1755-2559
Subject:
intraperitoneal injection,   etc   ; cognition; curcumin; exercise; hippocampus; males; memory; neurons;     Show all 8 Subjects
Abstract:
... A wide range of cognitive disorders, long-term potentiation (LTP) disorders, and biochemical changes have been reported in labyrinthectomy situations in the hippocampus of rodents. In order to investigate whether exercise and/or curcumin induce LTP and increase neurons in the hippocampus of unilateral labyrinthectomy male rats, after undergoing labyrinthectomy, animals were subjected to treadmill ...
DOI:
10.3920/CEP210041

6. The ability of remaining glomerular podocytes to adapt to the loss of their neighbours decreases with age

Author:
James van der Wolde; Kotaro Haruhara; Victor G. Puelles; David Nikolic-Paterson; John F. Bertram; Luise A. Cullen-McEwen
Source:
Cell and tissue research 2022 v.388 no.2 pp. 439-451
ISSN:
0302-766X
Subject:
intraperitoneal injection,   etc   ; albuminuria; diphtheria toxin; hypertrophy; phosphorylation; rapamycin; research;     Show all 7 Subjects
Abstract:
... Progressive podocyte loss is a feature of healthy ageing. While previous studies have reported age-related changes in podocyte number, density and size and associations with proteinuria and glomerulosclerosis, few studies have examined how the response of remaining podocytes to podocyte depletion changes with age. Mild podocyte depletion was induced in PodCʳᵉiDTR mice aged 1, 6, 12 and 18 months v ...
DOI:
10.1007/s00441-022-03611-2

7. Pharmacological blockade of angiotensin II receptor restores diabetes-associated reduction of store operated Ca2+ entry in adult cardiomyocytes

Author:
Yasin Gökçe; Orhan Erkan; Kamil Savaş; Taufiq Rahman; Nazmi Yaraş
Source:
Biochemical and biophysical research communications 2022 v.610 pp. 56-60
ISSN:
0006-291X
Subject:
intraperitoneal injection,   etc   ; adults; calcium; cardiomyocytes; cardiomyopathy; diabetes; males; research; streptozotocin;     Show all 9 Subjects
Abstract:
... The store-operated Ca²⁺ entry (SOCE) represents an important route for generating cellular Ca²⁺ signals that are implicated in physiological and various pathological scenarios that include diabetic cardiomyopathy (DM-CMP) which is well known to have Ca²⁺ dysregulation among other salient features. In this study, we investigated the role of SOCE in Ca²⁺ handling of cardiomyocytes obtained from adul ...
DOI:
10.1016/j.bbrc.2022.04.031

8. A low body-color regulating ability of spotted halibut Verasper variegatus: Evaluation of the roles of melanin-concentrating hormone and proopiomelanocortin systems

Author:
Daigo Yamaguchi; Satoshi Kasagi; Daisuke Shimizu; Tomoki Maeda; Akiyoshi Takahashi; Kanta Mizusawa
Source:
Fisheries science 2022 v.88 no.3 pp. 411-418
ISSN:
0919-9268
Subject:
intraperitoneal injection,   etc   ; Verasper variegatus; brain; color; dose response; fish; gene expression;     Show all 7 Subjects
Abstract:
... In teleosts, melanin-concentrating hormone (MCH) induces body brightening. On the other hand, α-melanophore-stimulating hormone (α-MSH), derived from the precursor proopiomelanocortin (POMC), leads to body darkening. In many teleosts, the expression level of pmch is high in light backgrounds, while that of pomc is low in dark backgrounds. In the present study, we investigated the ability of spotte ...
DOI:
10.1007/s12562-022-01600-6

9. Cloning and expression of kiss genes and regulation of feeding in Siberian sturgeon (Acipenser baerii)

Author:
Shaoqi Xu; Mei Wang; Ya Li; Ni Tang; Xin Zhang; Hu Chen; Shupeng Zhang; Yanling Liu; Jun Wang; Defang Chen; Zhiqiong Li
Source:
Fish physiology and biochemistry 2022 v.48 no.2 pp. 419-436
ISSN:
0920-1742
Subject:
intraperitoneal injection,   etc   ; Acipenser baerii; appetite; fasting; fish; food intake; ghrelin; hypothalamus; leptin;     Show all 9 Subjects
Abstract:
... In 1996, kiss was reported to regulate feeding in mammals, but studies are limited in fish. Our study aimed to explore the possible role of kiss in the regulation of feeding in Siberian sturgeon (Acipenser baerii). kiss1 and kiss2 were cloned, and the expression patterns were analyzed in Siberian sturgeon. The complete coding regions of kiss1 and kiss2 genes were 393 and 471 bp. Both kiss1 and kis ...
DOI:
10.1007/s10695-022-01055-7

10. Daidzein alleviates neuronal damage and oxidative stress via GSK3β/Nrf2 pathway in mice

Author:
Xuerui Wang; Zequn Yin; Xianshe Meng; Daigang Yang; Huawen Meng; Chenzhong Liao; Lingling Wei; Yuanli Chen; Xiaoxiao Yang; Jihong Han; Yajun Duan; Shuang Zhang
Source:
Journal of functional foods 2022 v.92 pp. 105060
ISSN:
1756-4646
Subject:
intraperitoneal injection,   etc   ; Parkinson disease; antioxidants; brain; daidzein; neurons; oxidative stress; plant estrogens;     Show all 8 Subjects
Abstract:
... Parkinson's disease (PD) is the most common neurodegenerative disease. Daidzein (DAI) is one of the most commonly ingested phytoestrogens with anti-oxidant properties. However, the effects of DAI on oxidative stress in PD has not been reported. In this study, we used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for intraperitoneal injection of C57/BL6J mice for continuous 7 days to simulate ...
DOI:
10.1016/j.jff.2022.105060

11. In Vivo Uranium Decorporation by a Tailor-Made Hexadentate Ligand

Author:
Bin Chen; Sheng Hong; Xing Dai; Ximeng Li; Qi Huang; Tingfeng Sun; Dehan Cao; Hailong Zhang; Zhifang Chai; Juan Diwu; Shuao Wang
Source:
Journal of the American Chemical Society 2022 v.144 no.25 pp. 11054-11058
ISSN:
1520-5126
Subject:
intraperitoneal injection,   etc   ; cations; chelation; desorption; drugs; geometry; ligands; phosphates; therapeutics; uranium; uranyl ions;     Show all 11 Subjects
Abstract:
... The sequestration of uranium, particularly from the deposited bones, has been an incomplete task in chelation therapy for actinide decorporation. Part of the reason is that all previous decorporation ligands are not delicately designed to meet the coordination requirement of uranyl cations. Herein, guided by DFT calculation, we elaborately design a hexadentate ligand (TAM-2LI-MAM₂), whose preorgan ...
DOI:
10.1021/jacs.2c00688

12. Effects of insulin and sitagliptin on early cardiac dysfunction in diabetic rats

Author:
Walaa Wadie; Gehad S. Ahmed; Amani N. Shafik; Mohamed El-sayed
Source:
Life sciences 2022 v.299 pp. 120542
ISSN:
0024-3205
Subject:
intraperitoneal injection,   etc   ; cardioprotective effect; insulin; insulin-dependent diabetes mellitus; interleukin-6; natriuretic peptides; streptozotocin;     Show all 7 Subjects
Abstract:
... Cardiac affection is common in diabetic patients. Although insulin exerts a cardioprotective role, it may not be enough to totally prevent this affection. The current study aimed to compare the cardioprotective effect of insulin alone or combined with sitagliptin in a rat model of type 1 diabetes mellitus. Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ; 60 mg/kg) ...
DOI:
10.1016/j.lfs.2022.120542

13. Identification, tissue distribution, and anorexigenic effect of amylin in Siberian sturgeon (Acipenser baeri)

Author:
Mei Wang; Shaoqi Xu; Ya Li; Ni Tang; Hu Chen; Shupeng Zhang; Yanling Liu; Jun Wang; Defang Chen; Xin Zhang; Zhiqiong Li
Source:
Comparative biochemistry and physiology 2022 v.263 pp. 111079
ISSN:
1095-6433
Subject:
intraperitoneal injection,   etc   ; Acipenser baerii; appetite; duodenum; food intake; ghrelin; goldfish; hypothalamus; insulin; somatostatin; tissue distribution;     Show all 11 Subjects
Abstract:
... Amylin is a 37-amino acid polypeptide that has been found to be involved in feeding regulation in some mammals, birds, and goldfish. We cloned amylin of Siberian sturgeon and detected its distribution pattern in 15 tissues. The expression levels in the periprandial period (pre-and post-feeding), the changes in the food intake, and the expression levels of related appetite factors after the intrape ...
DOI:
10.1016/j.cbpa.2021.111079

14. Enzyme-responsive nano-drug delivery system for combined antitumor therapy

Author:
Fangyuan Guo; Yunlong Jiao; Yinzhou Du; Shuai Luo; Weiyong Hong; Qiafan Fu; Aiqin Li; Guoping Wang; Gensheng Yang
Source:
International journal of biological macromolecules 2022 v.220 pp. 1133-1145
ISSN:
0141-8130
Subject:
intraperitoneal injection,   etc   ; biocompatibility; cancer therapy; collagen; curcumin; drugs; electricity; metalloproteinases; nanoparticles; neoplasms; peptides; polyesters; toxicity;     Show all 13 Subjects
Abstract:
... Efficient drug loading, tumor targeting, intratumoral penetration, and cellular uptake are the main factors affecting the effectiveness of drug delivery systems in oncotherapy. Based on the tumor microenvironment, we proposed to develop Curcumin (Cur)-loaded matrix metalloproteinase (MMP)-responsive nanoparticles (Cur-P-NPs) by static electricity, to enhance tumor targeting, cellular uptake, and d ...
DOI:
10.1016/j.ijbiomac.2022.08.123

15. The efficacy and toxicity of grayanoids as analgesics: A systematic review

Author:
Jian Yang; Jingyi Zhao; Jiquan Zhang
Source:
Journal of ethnopharmacology 2022 v.298 pp. 115581
ISSN:
0378-8741
Subject:
intraperitoneal injection,   etc   ; Rhododendron; analgesics; diterpenoids; grayanotoxin; pain; rheumatoid arthritis; sodium; systematic review; toxicity; traditional medicine;     Show all 11 Subjects
Abstract:
... Grayanoids are natural diterpenoids that are mostly found in the Ericaceae family, such as Rhododendron molle (Blume) G. Don (Relevant herb: nao yang hua), Rhododendron micranthum Turcz (also known as: zhao shan bai), which have traditionally been used to treat abdominal pain, cephalgia, and rheumatoid arthritis. The review investigated advancements in notable anti-nociception, toxicity, and proba ...
DOI:
10.1016/j.jep.2022.115581

16. Effect of the analgesics dipyrone, tramadol, and meloxicam on the behavior of laboratory rats

Author:
Jilma Alemán-Laporte; Gilbert Alvarado; Ana Tada Fonseca Brasil Antiorio; Jaime Fornaguera Trías; Mijail Rojas-Carvajal; Claudia Madalena Cabrera Mori
Source:
Journal of veterinary behavior 2022 v.57 pp. 24-30
ISSN:
1558-7878
Subject:
intraperitoneal injection,   etc   ; analgesia; analgesics; cannabinoids; ethics; experimental design; laws and regulations; locomotion; males; meloxicam; rats;     Show all 11 Subjects
Abstract:
... Awareness about the ethical use of laboratory animals has increased over recent decades alongside the development of strict guidelines and legislation concerning the welfare of animals in scientific research. Although minimization of animal suffering during experimentation is of paramount importance, it is sometimes neglected because of the presumed interference of analgesics on behavioral pattern ...
DOI:
10.1016/j.jveb.2022.08.001

17. 2‐Arachidonoyl glycerol suppresses gastric emptying via the cannabinoid receptor 1‐cholecystokinin signaling pathway in mice

Author:
Keita Ochiai; Rina Hirooka; Masayoshi Sakaino; Shigeo Takeuchi; Tohru Hira
Source:
Lipids 2022 v.57 no.3 pp. 173-181
ISSN:
0024-4201
Subject:
intraperitoneal injection,   etc   ; absorption; acetaminophen; antagonists; cannabinoid receptors; cell lines; cholecystokinin; cholecystokinin receptors; glycerol; mice; phenolsulfonphthalein; secretion;     Show all 12 Subjects
Abstract:
... 2‐Monoacylglycerol (2‐MAG) is one of the digestion products of dietary lipids. We recently demonstrated that a 2‐MAG, 2‐arachidonoyl glycerol (2‐AG) potently stimulated cholecystokinin (CCK) secretion via cannabinoid receptor 1 (CB1) in a murine CCK‐producing cell line, STC‐1. CCK plays a crucial role in suppressing postprandial gastric emptying. To examine the effect of 2‐AG on gastric emptying, ...
DOI:
10.1002/lipd.12341

18. Acute microcystin exposure induces reversible histopathological changes in Chinook Salmon (Oncorhynchus tshawytscha) and Atlantic Salmon (Salmo salar)

Author:
Ryan B. Shartau; Heindrich N. Snyman; Lenora Turcotte; Pearse McCarron; Julia C. Bradshaw; Stewart C. Johnson
Source:
Journal of fish diseases 2022 v.45 no.5 pp. 729-742
ISSN:
0140-7775
Subject:
intraperitoneal injection,   etc   ; Oncorhynchus tshawytscha; Salmo salar; algae; chronic exposure; fish; histopathology; liver; liver diseases; microcystins; seawater;     Show all 11 Subjects
Abstract:
... Atlantic Salmon (Salmo salar) and Chinook Salmon (Oncorhynchus tshawytscha) develop a severe liver disease called net‐pen liver disease (NPLD), which is characterized by hepatic lesions that include megalocytosis and loss of gross liver structure. Based on studies where salmonids have been exposed to microcystin (MC) via intraperitoneal injection, NPLD is believed to be caused by MC exposure, a he ...
DOI:
10.1111/jfd.13599

19. Development of an inactivated whole cell vaccine through immersion for immunoprophylaxis of Francisella orientalis infections in Nile tilapia (Oreochromis niloticus L.) fingerlings and juveniles

Author:
Thaís.F. Oliveira; Guilherme A. Quieróz; Marcia P. Leibowitz; Carlos Augusto Gomes Leal
Source:
Fish & shellfish immunology 2022 v.127 pp. 405-411
ISSN:
1050-4648
Subject:
intraperitoneal injection,   etc   ; Francisella; Oreochromis niloticus; adjuvants; antibiotics; fingerlings; immune response; juveniles; mortality; pathogens; shellfish; vaccination; vaccines;     Show all 13 Subjects
Abstract:
... Francisella orientalis infections, known as francisellosis, are one of the most important diseases affecting the production of Nile tilapia, causing high mortality rates in the most susceptible fish stages: fingerlings and juveniles. Antibiotic therapy is the method of choice for treating the disease, as there are no commercially available vaccines. In this study, we developed an inactivated whole ...
DOI:
10.1016/j.fsi.2022.06.040

20. Effects of IGF-1 on the Three-Dimensional Culture of Ovarian Preantral Follicles and Superovulation Rates in Mice

Author:
Shizhen Dai; Hanxue Zhang; Feng Yang; Wei Shang; Shenming Zeng
Source:
Biology 2022 v.11 no.6 pp. -
ISSN:
2079-7737
Subject:
intraperitoneal injection,   etc   ; alginates; culture media; follicular development; insulin-like growth factor I; mice; oocytes; progesterone; superovulation;     Show all 9 Subjects
Abstract:
... Insulin-like growth factor-1 (IGF-1) plays a crucial role during folliculogenesis, which has been demonstrated by previous research. However, the optimal IGF-1 dosage in the three-dimensional (3D) culture system is unknown. Mouse secondary follicles (140–150 µm) were cultured for 6 days within an alginate bead in a medium supplemented with 0 (G0), 5 ng/mL (G5), 10 ng/mL (G10), or 50 ng/mL IGF-1 (G ...
DOI:
10.3390/biology11060833