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1. In vivo monitoring platform of transplanted human stem cells using magnetic resonance imaging

Author:
Seungmin Han; Byunghoon Kang; Hye Young Son; Yuna Choi; Moo-Kwang Shin; Jongjin Park; Jeong-Ki Min; Daewon Park; Eun-Kyung Lim; Yong-Min Huh; Seungjoo Haam
Source:
Biosensors & bioelectronics 2021 v.178 pp. 113039
ISSN:
0956-5663
Subject:
intravenous injection,   etc   ; antibodies; biosensors; humans; magnetism;     Show all 5 Subjects
Abstract:
... . Additionally, MnOHo-Ab provides improved T1 MRI owing to the hollow structure of the MnOHo. Particularly, the anti-integrin β1 antibody (Ab) introduced in the MnOHo targets integrin β1 expressed in the entire stem cell lineage, enabling targeted monitoring regardless of the differentiation stage of the stem cells. Furthermore, we verified that intravenously injected MnOHo-Ab specifically targeted human ...
DOI:
10.1016/j.bios.2021.113039

2. Pharmacological torpor prolongs rat survival in lethal normobaric hypoxia

Author:
Nadezhda M. Zakharova; Yury S. Tarahovsky; Natalia P. Komelina; Maxim O. Khrenov; Anatoly L. Kovtun
Source:
Journal of thermal biology 2021 v.98 pp. 102906
ISSN:
0306-4565
Subject:
intravenous injection,   etc   ; ambient temperature; hibernation; hypoxia; oxygen; rats;     Show all 6 Subjects
Abstract:
... Resistance to hypoxia is one of the most prominent features of natural hibernation and is expected to be present in the pharmacological torpor (PT) that simulates hibernation. We studied resistance to lethal hypoxia (3.5% oxygen content) in rats under PT. To initiate PT, we used the previously developed pharmacological composition (PC) which, after a single intravenous injection, can induce ...
DOI:
10.1016/j.jtherbio.2021.102906

3. Intranasal versus intraperitoneal Myrj 59-stabilized cubosomes: A potential armamentarium of effective anti-diabetic therapy

Author:
Mai Mansour; Enas Elmowafy; Heba A. Gad
Source:
Colloids and surfaces 2021 v.199 pp. 111534
ISSN:
0927-7765
Subject:
intravenous injection,   etc   ; diabetes; drugs; gels; stabilizers;     Show all 5 Subjects
Abstract:
... The present study is concerned with the suitability of using Myrj 59, out-performing the commonly used stabilizer i.e., poloxamer, for preparation of cubosomes on one hand and gives an insight into the need for distinctive choice of delivery system and administration route towards better diabetes pharmacotherapy on the other hand. In light, repaglinide (REP) cubosomal dispersion and in-situ gel fo ...
DOI:
10.1016/j.colsurfb.2020.111534

4. Kupffer cell release of platelet activating factor drives dose limiting toxicities of nucleic acid nanocarriers

Author:
Meredith A. Jackson; Shrusti S. Patel; Fang Yu; Matthew A. Cottam; Evan B. Glass; Ella N. Hoogenboezem; R. Brock Fletcher; Bryan R. Dollinger; Prarthana Patil; Danielle D. Liu; Isom B. Kelly; Sean K. Bedingfield; Allyson R. King; Rachel E. Miles; Alyssa M. Hasty; Todd D. Giorgio; Craig L. Duvall
Source:
Biomaterials 2021 v.268 pp. 120528
ISSN:
0142-9612
Subject:
intravenous injection,   etc   ; biocompatible materials; lipids; liver; nanocarriers; nanomedicine; toxicity;     Show all 7 Subjects
Abstract:
... This work establishes that Kupffer cell release of platelet activating factor (PAF), a lipidic molecule with pro-inflammatory and vasoactive signaling properties, dictates dose-limiting siRNA nanocarrier-associated toxicities. High-dose intravenous injection of siRNA-polymer nano-polyplexes (si-NPs) elicited acute, shock-like symptoms in mice, associated with increased plasma PAF and consequently ...
DOI:
10.1016/j.biomaterials.2020.120528

5. Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF₄–NaGdF₄ Core–Shell Nanoparticles

Author:
Armita Dash; Barbara Blasiak; Boguslaw Tomanek; Peter Latta; Frank C. J. M. van Veggel
Source:
ACS applied materials & interfaces 2021 v.13 no.21 pp. 24345-24355
ISSN:
1944-8252
Subject:
intravenous injection,   etc   ; adenocarcinoma; antigens; humans; magnetism; permeability; prostatic neoplasms;     Show all 7 Subjects
Abstract:
... post-24 h of their intravenous injection. On the other hand, in vivo passive targeting showed preferential accumulation of NPs at tumor sites only within 2 h of their injection, ascribed to the enhanced permeation and retention effect of the tumor. A biodistribution study employing the harvested organs of mice, post-24 h injection of NPs, quantified active targeting as nearly twice as efficient ...
DOI:
10.1021/acsami.0c19273

6. Current advances in nanomaterials affecting morphology, structure, and function of erythrocytes

Author:
Yaxian Tian; Zhaoju Tian; Yanrong Dong; Xiaohui Wang; Linsheng Zhan
Source:
RSC advances 2021 v.11 no.12 pp. 6958-6971
ISSN:
2046-2069
Subject:
intravenous injection,   etc   ; biocompatibility; drugs; erythrocytes; longevity; nanomedicine;     Show all 6 Subjects
Abstract:
... In recent decades, nanomaterials have been widely used in the field of biomedicine due to their unique physical and chemical properties, and have shown good prospects for in vitro diagnosis, drug delivery, and imaging. With regard to transporting nanoparticles (NPs) to target tissues or organs in the body intravenously or otherwise, blood is the first tissue that NPs come into contact with and is ...
DOI:
10.1039/d0ra10124a

7. Envenomation by Centruroides pococki scorpion with neuromuscular toxicity

Author:
Weniko Caré; Sébastien Larréché; Paul Busser; Laurène Dufayet; Dominique Vodovar; Luc de Haro; Jérôme Langrand
Source:
Toxicon 2021 v.190 pp. 39-40
ISSN:
0041-0101
Subject:
intravenous injection,   etc   ; Centruroides; antivenoms; humans; toxicity; Guadeloupe;     Show all 6 Subjects
Abstract:
... Cases of human envenomation by Centruroides pococki are exceptionally reported in human. We report a Class III human envenomation by C. pococki in Guadeloupe, French West Indies, with neuromuscular toxicity that has never been described before. Symptoms resolved within a few hours, without the need for intravenous scorpion-specific antivenom. ...
DOI:
10.1016/j.toxicon.2020.12.005

8. Pharmacokinetics and effects on clinical and physiological parameters following a single bolus dose of propofol in common marmosets (Callithrix jacchus)

Author:
Kanako Muta; Takako Miyabe‐Nishiwaki; Kenichi Masui; Isao Yajima; Tomoya Iizuka; Akihisa Kaneko; Ryohei Nishimura
Source:
Journal of veterinary pharmacology and therapeutics 2021 v.44 no.1 pp. 18-27
ISSN:
0140-7783
Subject:
intravenous injection,   etc   ; Callithrix jacchus; anesthesia; models; pharmacokinetics; sevoflurane;     Show all 6 Subjects
Abstract:
... The objectives of this study were (a) to establish a population pharmacokinetic model and (b) to investigate the clinical and physiological effects of a single bolus dose of propofol in common marmosets. In Study 1, pharmacokinetic analysis was performed in six marmosets under sevoflurane anaesthesia. 8 mg/kg of propofol was administrated at a rate of 4 mg kg⁻¹ min⁻¹. Blood samples were collected ...
DOI:
10.1111/jvp.12905

9. Two-Photon Excitation-Based Imaging Postprocessing Algorithm Model for Background-Free Bioimaging

Author:
Xiu Wang; Wei Yuan; Ming Xu; Fuyou Li
Source:
Analytical chemistry 2021 v.93 no.4 pp. 2551-2559
ISSN:
1520-6882
Subject:
intravenous injection,   etc   ; algorithms; analytical chemistry; bioimaging; bioluminescence; fluorescence; light intensity; models;     Show all 8 Subjects
Abstract:
... background easily after intravenous injection. This image postprocessing method combined with special two-photon excited luminescent materials can conduct biological imaging from complex background interference without using expensive instruments or delicate materials, which holds great promise for accurate biological imaging. ...
DOI:
10.1021/acs.analchem.0c04611

10. Subsequent Ultrasound Vascular Targeting Therapy of Hepatocellular Carcinoma Improves the Treatment Efficacy

Author:
Laith R. Sultan; Mrigendra B. Karmacharya; Stephen J. Hunt; Andrew K.W. Wood; Chandra M. Sehgal
Source:
Biology 2021 v.10 no.2 pp. -
ISSN:
2079-7737
Subject:
intravenous injection,   etc   ; angiogenesis; diethylnitrosamine; hepatoma; histology; ingestion; microbubbles; necrosis; ultrasonics; viability;     Show all 10 Subjects
Abstract:
... of AVUS. HCC was induced in 30 Wistar rats by oral ingestion of diethylnitrosamine (DEN) for 12 weeks. A total of 24 rats received treatment with low intensity, 2.8 MHz ultrasound with an intravenous injection of microbubbles. Treated rats were divided into three groups: single therapy group (ST), 2-days subsequent therapy group (2DST), and 7-days subsequent therapy group (7DST). A sham control group ...
DOI:
10.3390/biology10020079

11. Evaluation of bone and kidney toxicity of BT2-peg2, a potential carrier for the targeted delivery of antibiotics to bone

Author:
Zaineb A.F. Albayati; Narsimha R. Penthala; Shobanbabu Bommagani; Ginell R. Post; Mark S. Smeltzer; Peter A. Crooks
Source:
Toxicology reports 2021 v.8 pp. 359-364
ISSN:
2214-7500
Subject:
intravenous injection,   etc   ; animal models; histopathology; nephrotoxicity; pharmacokinetics; toxicology; vancomycin;     Show all 7 Subjects
Abstract:
... Previous studies have demonstrated that the bone targeting agent BT2-peg2 (BT2-minipeg2, 9), when conjugated to vancomycin and delivered systemically by intravenous (IV) or intraperitoneal (IP) injection accumulates in bone to a greater degree than vancomycin alone, but that this accumulation is associated with severe nephrotoxicity. To determine whether this nephrotoxicity could be attributed to ...
DOI:
10.1016/j.toxrep.2021.02.002

12. Dual-Stimulus Responsive Near-Infrared Reversible Ratiometric Fluorescent and Photoacoustic Probe for In Vivo Tumor Imaging

Author:
Xiao Liu; Xiangyang Gong; Jie Yuan; Xiaopeng Fan; Xingxing Zhang; Tianbing Ren; Sheng Yang; Ronghua Yang; Lin Yuan; Xiao-Bing Zhang
Source:
Analytical chemistry 2021 v.93 no.13 pp. 5420-5429
ISSN:
1520-6882
Subject:
intravenous injection,   etc   ; adenosine; analytical chemistry; dyes; energy; fluorescence; neoplasms; resection; rhodamines; silicon;     Show all 10 Subjects
Abstract:
... , and ATP/H⁺ recognition units that could only be activated when both H⁺ and ATP were connected to the acceptor. The ATP-pH probe is reversibly activated by both the H⁺ and ATP, which effectively reduces the cumulative response of the probe in circulation after intravenous injection. Further, the NIR ratiometric property of the probe makes it suitable for in vivo imaging. Finally, our probe ...
DOI:
10.1021/acs.analchem.0c04804

13. Synthesis of one-for-all type Cu5FeS4 nanocrystals with improved near infrared photothermal and Fenton effects for simultaneous imaging and therapy of tumor

Author:
Zhaojie Wang; Yue Wang; Honghua Guo; Nuo Yu; Qian Ren; Qin Jiang; Jindong Xia; Chen Peng; Haijun Zhang; Zhigang Chen
Source:
Journal of colloid and interface science 2021 v.592 pp. 116-126
ISSN:
0021-9797
Subject:
intravenous injection,   etc   ; hydroxyl radicals; magnetism; mice; nanocrystals; neoplasms; pH; wavelengths;     Show all 8 Subjects
Abstract:
... ) under a wide pH range (e.g., pH = 5.4–7.4) to realize the chemodynamic effect. In addition, Cu₅FeS₄ can be employed as an efficient MRI contrast agent. When Cu₅FeS₄ dispersion is intravenously injected into the mouse, the tumor can be detected by MRI as well as thermal imaging, and eliminated through photothermal-enhanced chemodynamic effect. Therefore, Cu₅FeS₄ can be used as an efficient “one-for-all ...
DOI:
10.1016/j.jcis.2021.02.037

14. Tailor-Made Single-Core PLGA Microbubbles as Acoustic Cavitation Enhancers for Therapeutic Applications

Author:
Shani Tsirkin; Riki Goldbart; Tamar Traitel; Joseph Kost
Source:
ACS applied materials & interfaces 2021 v.13 no.22 pp. 25748-25758
ISSN:
1944-8252
Subject:
intravenous injection,   etc   ; acoustics; blood-brain barrier; microbubbles; permeability; swine; ultrasonics;     Show all 7 Subjects
Abstract:
... that they exhibit (i.e., their cavitation dose). We showed that single-core MBs filled with C₃F₈ gas can produce cavitation effects for extended periods under continuous circulation. These MBs exhibited high stability, and their cavitation activity was not affected by prior circulation in the system. Preliminary in vivo results demonstrated that intravenously injected MBs did not cause adverse effects ...
DOI:
10.1021/acsami.1c04770

15. Pharmacokinetics of exogenous GIP(1-42) in C57Bl/6 mice; Extremely rapid degradation but marked variation between available assays

Author:
Geke Aline Boer; Bolette Hartmann; Jens Juul Holst
Source:
Peptides 2021 v.136 pp. 170457
ISSN:
0196-9781
Subject:
intravenous injection,   etc   ; females; gastric inhibitory polypeptide; half life; heparin; intraperitoneal injection; pharmacokinetics;     Show all 7 Subjects
Abstract:
... inhibition in conscious female C57Bl/6 mice. Secondly, we compared total and intact GIP levels measured by an in-house RIA and commercially available ELISA kits to determine the suitability of these methods for in vivo and in vitro measurements. GIP half-life following intravenous injection amounted to 93 ± 2 s, which was extended to 5 ± 0.6 min by inhibition of DPP-4. Intact GIP levels following ...
DOI:
10.1016/j.peptides.2020.170457

16. Marine polymeric microneedles for transdermal drug delivery

Author:
Tânia Moniz; Sofia A. Costa Lima; Salette Reis
Source:
Carbohydrate polymers 2021 v.266 pp. 118098
ISSN:
0144-8617
Subject:
intravenous injection,   etc   ; alginates; chitosan; drugs; hyaluronic acid; markets; permeability; polymers;     Show all 8 Subjects
Abstract:
... Transdermal drug delivery is considered one of the most attractive routes for administration of pharmaceutic and cosmetic active ingredients due to the numerous advantages, especially over oral and intravenous methodologies. However, some limitations still exist mainly regarding the need to improve the drugs permeation across the skin. For this, several strategies have been described, considering ...
DOI:
10.1016/j.carbpol.2021.118098

17. Clinical use of the parasympathetic tone activity index as a measurement of postoperative analgaesia in dogs undergoing ovariohysterectomy

Author:
Ismael Hernández-Avalos; Alex Valverde; José Antonio Ibancovichi-Camarillo; Pedro Sánchez-Aparicio; Sergio Recillas-Morales; Desiderio Rodríguez-Velázquez; Jorge Osorio-Avalos; Luis Armando Magdaleno-Torres; Julio Chavez-Monteagudo; Carlos Manuel Acevedo-Arcique
Source:
Journal of Veterinary Research 2021 v.65 no.1 pp. 117-123
ISSN:
2450-8608
Subject:
intravenous injection,   etc   ; acetaminophen; meloxicam; pain; postoperative care; spaying; veterinary medicine;     Show all 7 Subjects
Abstract:
... While the current tools to assess canine postoperative pain using physiological and behavioural parameters are reliable, an objective method such as the parasympathetic tone activity (PTA) index could improve postoperative care. The aim of the study was to determine the utility of the PTA index in assessing postoperative analgaesia. Thirty healthy bitches of different breeds were randomly allocate ...
DOI:
10.2478/jvetres-2021-0004

18. Furosemide administration onehour before bone scintigraphy examination in horses does not improve the image quality or reduce the radiation dose rate

Author:
Mahmoud Mageed; Julius Wegert; Shahlaa Dyab; Kerstin Gerlach
Source:
Veterinary radiology & ultrasound 2021 v.62 no.1 pp. 126-132
ISSN:
1058-8183
Subject:
intravenous injection,   etc   ; furosemide; head; horses; kidneys; pelvis; radiology; scintigraphy; ultrasonics;     Show all 9 Subjects
Abstract:
... This prospective, cross‐sectional, pilot study aimed to investigate the effects of furosemide as a diuretic on the image quality of bone scintigraphy performed using ⁹⁹ᵐTc‐HDP and to investigate the impact of furosemide on the radiation dose rate. Thirty‐one horses undergoing bone scintigraphy were included. The horses were divided into the control (n = 14) and furosemide group (n = 17), which rec ...
DOI:
10.1111/vru.12917

19. Dual-Stimuli Responsive Polymeric Micelles for the Effective Treatment of Rheumatoid Arthritis

Author:
Liming He; Xianyan Qin; Donghao Fan; Chenglan Feng; Qin Wang; Jiyu Fang
Source:
ACS applied materials & interfaces 2021 v.13 no.18 pp. 21076-21086
ISSN:
1944-8252
Subject:
intravenous injection,   etc   ; dexamethasone; metalloproteinases; micelles; models; pH; polyethylene; rheumatoid arthritis;     Show all 8 Subjects
Abstract:
... The nontargeted distribution and uncontrolled in vivo release of drugs impede their efficacy in the treatment of rheumatoid arthritis (RA). Delivering drugs to arthritic joints and releasing drugs on demand are a feasible solution to achieve the effective treatment of RA. In this paper, we report a facile method to assemble dual-stimuli responsive polymeric micelles from polyethylene glycol–phenyl ...
DOI:
10.1021/acsami.1c04953

20. Initiation of Vancomycin Therapy and the First Therapeutic Drug Monitoring

Author:
Inga Mauliņa; Angelika Krūmiņa; Aleksandra Aitullina; Roberts Erts; Katrīna Bandere; Dace Bandere; Eva Strīķe
Source:
Proceedings of the Latvian Academy of Sciences 2021 v.75 no.1 pp. 40-46
ISSN:
1407-009X
Subject:
intravenous injection,   etc   ; adults; hospitals; observational studies; renal function; vancomycin; Latvia;     Show all 7 Subjects
Abstract:
... There have been a limited number of studies in Latvia that were focused on vancomycin therapeutic drug monitoring (TDM), especially during the initiation phase of the therapy. The aim of this study was to investigate details of vancomycin therapy in its initiation phase and to analyse the results of the first therapeutic drug monitoring within a multidisciplinary hospital in Latvia. A retrospectiv ...
DOI:
10.2478/prolas-2021-0007