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1. Blood urea in preterm infants on routine parenteral nutrition: A multiple linear regression analysis

Author:
Giretti, Ilaria; Correani, Alessio; Antognoli, Luca; Monachesi, Chiara; Marchionni, Paolo; Biagetti, Chiara; Bellagamba, Maria Paola; Cogo, Paola; D'Ascenzo, Rita; Burattini, Ilaria; Carnielli, Virgilio P.
Source:
Clinical nutrition 2021 v.40 no.1 pp. 153-156
ISSN:
0261-5614
Subject:
intravenous injection,   etc   ; amino acids; birth weight; blood; creatinine; data collection; distress; energy intake; gestational age; hematologic tests; human physiology; parenteral feeding; patent ductus arteriosus; patients; premature birth; regression analysis; small for gestational age; steroids; umbilical arteries; urea;     Show all 20 Subjects
Abstract:
... Blood urea is considered a marker of amino acid utilization in preterm infants on routine parenteral nutrition. However, the association between blood urea and intravenous amino acid intake remains debated.To evaluate the association between blood urea and both nutrition and clinical data, in a large cohort of preterm infants.Consecutively admitted preterm infants with a gestational age of less th ...
DOI:
10.1016/j.clnu.2020.04.039

2. Pkweb: An online application for pharmacokinetic data analysis

Author:
Dong, Zhaomin; Fan, Xiarui; Fan, Wenhong; Chang, Hong; Xu, Yilu; Li, Tong; Su, Ming
Source:
Environmental technology & innovation 2020 v.19 pp. 100838
ISSN:
2352-1864
Subject:
intravenous injection,   etc   ; Internet; models; pharmacokinetics; user interface;     Show all 5 Subjects
Abstract:
... This research presents a web-based application, pkweb (https://pkweb.hhra.net), with a user-friendly interface and a range of functions for pharmacokinetic (PK) data analysis. Capabilities include simulation of PK data, which integrates 27 modules (e.g., intravenous (IV) bolus injection, IV infusion and extravascular administration) and modeling the fitness of PK data. The pkweb tool provides diff ...
DOI:
10.1016/j.eti.2020.100838

3. Contribution of intravenous medication to water and sodium intake in upper and lower gastrointestinal surgical patients

Author:
Austin, Peter D.; Joskova, Vera; Patkova, Anna; Elia, Marinos
Source:
Nutrition 2020 v.78 pp. 110808
ISSN:
0899-9007
Subject:
intravenous injection,   etc   ; acetaminophen; antibiotics; gastrointestinal system; hospitals; patients; sodium;     Show all 7 Subjects
Abstract:
... The quantitative importance of prescribed intravenous (IV) medication to water and sodium intake in routine clinical practice is undocumented, with uncertain influence on clinical outcomes. The present study aimed to redress this issue in surgical patients with gastrointestinal problems.The prescription and administration of IV medication and fluids were retrospectively reviewed for water and sodi ...
DOI:
10.1016/j.nut.2020.110808

4. Successful treatment with plasma exchange followed by intravenous immunoglobulin in a critically ill patient with COVID-19

Author:
Shi, Hua; Zhou, Chaomin; He, Pinghong; Huang, Sheng; Duan, Youjun; Wang, Xuesheng; Lin, Kexiong; Zhou, Chao; Zhang, Xiangyan; Zha, Yan
Source:
International journal of antimicrobial agents 2020 v.56 no.2 pp. 105974
ISSN:
0924-8579
Subject:
intravenous injection,   etc   ; Coronavirinae; Coronavirus infections; anti-infective agents; diarrhea; patients;     Show all 6 Subjects
Abstract:
... Here we report a case of a laboratory-confirmed 2019 novel coronavirus (2019-nCoV)-infected patient with COVID-19 (coronavirus disease 2019) who developed respiratory failure and shock accompanied by persistent diarrhoea despite conventional therapeutic interventions. The patient avoided mechanical ventilation and showed an immediate clinical and radiological improvement following treatment with i ...
DOI:
10.1016/j.ijantimicag.2020.105974
PubMed:
32298745
PubMed Central:
PMC7194512

5. Comparison of the neuromuscular blocking effects of cisatracurium during isoflurane or propofol anesthesia in dogs

Author:
Chen, I-Ying; Liang, Yun-Yu; Chen, Kuan-Sheng; Lee, Wei-Ming; Wang, Hsien-Chi
Source:
Veterinary anaesthesia and analgesia 2020 v.47 no.4 pp. 454-462
ISSN:
1467-2987
Subject:
intravenous injection,   etc   ; anesthesia; dogs; dose response; females; isoflurane; males; surgery;     Show all 8 Subjects
Abstract:
... To compare the neuromuscular blocking effects of cisatracurium during isoflurane versus propofol anesthesia in dogs.Prospective, randomized study.A total of 20 healthy, client-owned dogs (16 females, four males) weighing 12.5–22 kg and aged 1–8 years.Dogs undergoing elective surgery were randomized in equal numbers to an isoflurane (ISO) or propofol (PPF) group. Other drugs used during anesthesia ...
DOI:
10.1016/j.vaa.2020.03.002

6. Accelerating the development of novel technologies and tools for the subcutaneous delivery of biotherapeutics

Author:
Collins, David S.; Sánchez-Félix, Manuel; Badkar, Advait V.; Mrsny, Randall
Source:
Journal of controlled release 2020 v.321 pp. 475-482
ISSN:
0168-3659
Subject:
intravenous injection,   etc   ; biopharmaceuticals; commercialization; drug development; experts; industry; monoclonal antibodies;     Show all 7 Subjects
Abstract:
... Subcutaneous (SC) delivery of biotherapeutics is well established as a route of administration across many therapeutic areas and has been shown to be effective and well-tolerated. It can offer several advantages over intravenous administration. This notwithstanding, there remain critical development issues and knowledge gaps in SC drug delivery. To articulate and address these issues, the SC Drug ...
DOI:
10.1016/j.jconrel.2020.02.036

7. Renewing the Fight Against TB with an Old Vaccine

Author:
Scriba, Thomas J.; Mizrahi, Valerie
Source:
Cell 2020 v.180 no.5 pp. 829-831
ISSN:
0092-8674
Subject:
intravenous injection,   etc   ; Primates; tuberculosis; vaccination; vaccine development; vaccines;     Show all 6 Subjects
Abstract:
... Prevention of pulmonary tuberculosis by vaccination has proven an elusive goal. In a recent study, Darrah et al. show that prevention of infection and disease can be achieved in non-human primates by intravenous administration of the century-old vaccine BCG. This finding heralds a step-change in the approach to TB vaccine development. ...
DOI:
10.1016/j.cell.2020.02.024

8. Measurement of isoagglutinins in immunoglobulins for intravenous application by flow cytometry

Author:
Bürzle, Marc; Hubsch, Alphonse; Spiegl, Nicole; Roten, Thomas; Marques, Adriano; Martig, Lukas; Shebl, Amgad; Stadler, Dominik
Source:
Analytical biochemistry 2020 v.591 pp. 113534
ISSN:
0003-2697
Subject:
intravenous injection,   etc   ; antibodies; erythrocytes; flow cytometry; fluorescence; hemolysis; immunoglobulins;     Show all 7 Subjects
Abstract:
... Isoagglutinins present in intravenous immunoglobulin (IVIG) products have been linked to haemolysis. Therefore, accurately assessing isoagglutinin content in IVIG products is important. The standard European Pharmacopoeia (Ph.Eur.) direct assay is limited by low precision. Here, we describe the development of a fluorescence-activated cell sorting (FACS) method for assessing isoagglutinin levels. S ...
DOI:
10.1016/j.ab.2019.113534

9. Dextran sulfate sodium-induced colitis and ginseng intervention altered oral pharmacokinetics of cyclosporine A in rats

Author:
Yang, Ying; Hu, Nan; Gao, Xue-Jiao; Li, Ting; Yan, Zhi-Xiang; Wang, Pan-Pan; Wei, Bin; Li, Sai; Zhang, Zai-Jun; Li, Song-Lin; Yan, Ru
Source:
Journal of ethnopharmacology 2021 v.265 pp. 113251
ISSN:
0378-8741
Subject:
intravenous injection,   etc   ; P-glycoproteins; Panax; blood; cyclosporine; cytochrome P-450; dextran sulfate; disease susceptibility; drinking water; enzymes; excretion; feces; human cell lines; hydroxylation; immune response; intestinal microorganisms; intestines; liver; medicinal plants; metabolites; microbial culture; oral administration; pharmacokinetics; physiological transport; plant extracts; rats; tight junctions; traditional medicine; ulcerative colitis;     Show all 29 Subjects
Abstract:
... Application of cyclosporine A (CsA) as a rescue treatment in acute severe ulcerative colitis (UC) is limited by its narrow therapeutic window and great interpatient variability. As a substrate of cytochrome P450 3A enzyme (CYP3A) and P-glycoprotein (P-gp), the oral pharmacokinetics of CsA is susceptible to disease status and concomitant medications. Combined treatment with ginseng, a famous medici ...
DOI:
10.1016/j.jep.2020.113251

10. Effect of Morphine Administration on Social and Non-Social Play Behaviour in Calves

Author:
Sutherland, Mhairi; Worth, Gemma; Cameron, Catherine; Verbeek, Else
Source:
Animals 2019 v.9 no.2
ISSN:
2076-2615
Subject:
intravenous injection,   etc   ; calves; cortisol; morphine;     Show all 4 Subjects
Abstract:
... The objective of this study was to evaluate the effect of morphine on social and non-social play behaviour in calves. Twelve calves experienced four treatments in a cross over 2 × 2 factorial design: Calves received an intravenous injection of morphine or saline 10 min prior to being tested individually or in pairs in an arena for 20 min. Play behaviour was continuously recorded in the arena ...
DOI:
10.3390/ani9020056
PubMed:
30759872
PubMed Central:
PMC6406493

11. Immunoglobulin G Glycoprofiles are Unaffected by Common Bottom-Up Sample Processing

Author:
Amez-Martín, Manuela; Wuhrer, Manfred; Falck, David
Source:
Journal of proteome research 2020 v.19 no.10 pp. 4158-4162
ISSN:
1535-3907
Subject:
intravenous injection,   etc   ; acid hydrolysis; biomarkers; biopharmaceuticals; denaturation; glycopeptides; glycoproteomics; glycosylation; heat; immunoglobulin G; proteome; sialic acids;     Show all 12 Subjects
Abstract:
... Immunoglobulin G (IgG) glycosylation is a key post-translational modification in regulating IgG function. It is therefore a prominent target for biomarker discovery and a critical quality attribute of antibody-based biopharmaceuticals. A common approach for IgG glycosylation analysis is the measurement of tryptic glycopeptides. Glycosylation stability during sample processing is a key prerequisite ...
DOI:
10.1021/acs.jproteome.0c00656

12. Investigation of selected respiratory effects of (dex)medetomidine in healthy Beagles

Author:
Pleyers, Tekla; Levionnois, Olivier; Siegenthaler, Joëlle; Spadavecchia, Claudia; Raillard, Mathieu
Source:
Veterinary anaesthesia and analgesia 2020 v.47 no.5 pp. 667-671
ISSN:
1467-2987
Subject:
intravenous injection,   etc   ; Beagle; adults; analysis of variance; chest; dexmedetomidine; dogs; electric impedance; medetomidine; respiratory rate; tomography;     Show all 11 Subjects
Abstract:
... To investigate the effects of sedative doses of intravenous (IV) medetomidine (MED) or dexmedetomidine (DEX) on selected respiratory variables in dogs.Randomized, blinded, crossover study.A total of eight healthy adult research Beagles.Dogs breathing room air had an electrical impedance tomography belt placed around the chest and were maintained in right lateral recumbency. Respiratory rate (fR) i ...
DOI:
10.1016/j.vaa.2020.05.001

13. Glycol chitosan-based renal docking biopolymeric nanomicelles for site-specific delivery of the immunosuppressant

Author:
Kim, Chang Seong; Mathew, Ansuja Pulickal; Uthaman, Saji; Moon, Myeong Ju; Bae, Eun Hui; Kim, Soo Wan; Park, In-Kyu
Source:
Carbohydrate polymers 2020 v.241 pp. 116255
ISSN:
0144-8617
Subject:
intravenous injection,   etc   ; adverse effects; chitosan; drugs; encapsulation; hydrophobicity; in vivo studies; kidneys; micelles; polymers; tacrolimus; toxicity;     Show all 12 Subjects
Abstract:
... In this study, we propose the use of glycol chitosan for the targeted delivery of hydrophobic drugs such as tacrolimus (TAC) towards the kidney. We synthesized a hydrophobically modified glycol chitosan (HGC) polymeric nanomicelle followed by loading TAC resulting in TAC loaded HGC nanomicelles (HGC-TAC). The HGC-TAC nanomicelles displayed spherical morphology with superior drug loading content an ...
DOI:
10.1016/j.carbpol.2020.116255

14. Antinociceptive Effect of Intravenous Regional Analgesia in Horses Underwent Selected Short-Time Distal Limb Surgeries

Author:
Samy, Alaa; Elmetwally, Mohammed; El-khodery, Sabry A.
Source:
Journal of equine veterinary science 2020 v.91 pp. 103113
ISSN:
0737-0806
Subject:
intravenous injection,   etc   ; analgesia; analgesic effect; anesthesia; draft horses; lidocaine; pain; sodium; surgery; thiopental;     Show all 10 Subjects
Abstract:
... The aim of the present study was to establish appropriate doses for both lidocaine hydrochloride (Hcl) and mepivacaine in intravenous regional analgesia (IVRA) and to assess their intraoperative and postoperative analgesic effects in horses with distal limb surgeries. A total of 55 draft horses were included in the present study. Six clinically healthy horses were selected randomly for establishin ...
DOI:
10.1016/j.jevs.2020.103113

15. Patient characteristics and clinical outcomes in a specialised intestinal failure unit: An observational cohort study

Author:
Eriksen, Marcel Kjærsgaard; Jørgensen, Simon Mark Dahl; Lemming, Lars Erik; Lal, Simon; Dahlerup, Jens Frederik; Hvas, Christian Lodberg
Source:
Clinical nutrition ESPEN 2020 v.38 pp. 253-262
ISSN:
2405-4577
Subject:
intravenous injection,   etc   ; blood flow; central venous catheters; cohort studies; comorbidity; confidence interval; intestines; mortality; patients;     Show all 9 Subjects
Abstract:
... Intestinal failure (IF) is defined by a need for intravenous (IV) supplementation. Patients may present with multiple morbidities, and IV treatments carry a risk for catheter-related complications. Few studies described patient characteristics and clinical outcomes according to type of IF.We consecutively included patients who were admitted to a newly established inpatient IF unit (IFU) from 2013 ...
DOI:
10.1016/j.clnesp.2020.04.002

16. Tipping point: When patients stop eating and drinking in the last phase of their life

Author:
Blum, David; Jensen, Wiebke; Ullrich, Anneke; Hlawatsch, Cornelia; Bokemeyer, Carsten; Oechsle, Karin
Source:
Clinical nutrition ESPEN 2020 v.38 pp. 280-282
ISSN:
2405-4577
Subject:
intravenous injection,   etc   ; death; deglutition; distress; food intake; management systems; neoplasms; patients; retrospective studies; sociodemographic characteristics; taste;     Show all 11 Subjects
Abstract:
... Eating and drinking are essential also in social life. Nutrition and hydration (N&H) at end of life are often a source of discussion and distress. Stopping eating and drinking is a defining element of the dying phase, however, this time point is not well defined. The aim of this retrospective analysis was to investigate whether such a time point can be detected, whether there are specific characte ...
DOI:
10.1016/j.clnesp.2020.04.012

17. Systematic overview of soft materials as a novel frontier for MRI contrast agents

Author:
Gallo, Enrico; Rosa, Elisabetta; Diaferia, Carlo; Rossi, Filomena; Tesauro, Diego; Accardo, Antonella
Source:
RSC advances 2020 v.10 no.45 pp. 27064-27080
ISSN:
2046-2069
Subject:
intravenous injection,   etc   ; administered dose; diagnostic techniques; gadolinium; humans; magnetic resonance imaging; pharmacokinetics; physiological state; thermodynamics; toxicity;     Show all 10 Subjects
Abstract:
... Magnetic resonance imaging (MRI) is a well-known diagnostic technique used to obtain high quality images in a non-invasive manner. In order to increase the contrast between normal and pathological regions in the human body, positive (T1) or negative (T2) contrast agents (CAs) are commonly intravenously administered. The most efficient class of T1-CAs are based on kinetically stable and thermodynam ...
DOI:
10.1039/d0ra03194a

18. Comprehensive toxicokinetic analysis reveals major interspecies differences in absorption, distribution and elimination of citrinin in pigs and broiler chickens

Author:
Meerpoel, Celine; Vidal, Arnau; Huybrechts, Bart; Tangni, Emmanuel K.; De Saeger, Sarah; Croubels, Siska; Devreese, Mathias
Source:
Food and chemical toxicology 2020 v.141 pp. 111365
ISSN:
0278-6915
Subject:
intravenous injection,   etc   ; bioavailability; biotransformation; blood proteins; broiler chickens; citrinin; humans; pharmacokinetics; protein binding; swine; toxicology;     Show all 11 Subjects
Abstract:
... A comprehensive toxicokinetic analysis of citrinin (CIT) revealed interspecies differences for all toxicokinetic parameters and in absolute oral bioavailability. Oral bioavailability for CIT was complete for broilers (113–131%), while ranging from 37 to 44% in pigs. CIT was more rapidly absorbed in pigs (Tₘₐₓ = 0.92 h) compared to broiler chickens (Tₘₐₓ = 7.33 h). The elimination of CIT was slower ...
DOI:
10.1016/j.fct.2020.111365

19. Effects of constant rate infusions of dexmedetomidine, remifentanil and their combination on minimum alveolar concentration of sevoflurane in dogs

Author:
Akashi, Natsuki; Murahata, Yusuke; Kishida, Hikaru; Hikasa, Yoshiaki; Azuma, Kazuo; Imagawa, Tomohiro
Source:
Veterinary anaesthesia and analgesia 2020 v.47 no.4 pp. 490-498
ISSN:
1467-2987
Subject:
intravenous injection,   etc   ; Beagle; adults; anesthesia; dexmedetomidine; dogs; females; males; oxygen; sevoflurane; synergism;     Show all 11 Subjects
Abstract:
... To evaluate the effects of constant rate infusions (CRIs) of dexmedetomidine and remifentanil alone and their combination on minimum alveolar concentration (MAC) of sevoflurane in dogs.Randomized crossover experimental study.A total of six (three males, three females) healthy, adult neutered Beagle dogs weighing 12.6 ± 1.4 kg.Anesthesia was induced with sevoflurane in oxygen until endotracheal int ...
DOI:
10.1016/j.vaa.2020.04.002

20. Effects of ketamine or midazolam continuous rate infusions on alfaxalone total intravenous anaesthesia requirements and recovery quality in healthy dogs: a randomized clinical trial

Author:
Bustamante, Rocío; Gómez de Segura, Ignacio A.; Canfrán, Susana; Aguado, Delia
Source:
Veterinary anaesthesia and analgesia 2020 v.47 no.4 pp. 437-446
ISSN:
1467-2987
Subject:
intravenous injection,   etc   ; acepromazine; alfaxalone; analysis of variance; anesthesia; dogs; ketamine; methadone; randomized clinical trials;     Show all 9 Subjects
Abstract:
... To determine the alfaxalone dose reduction during total intravenous anaesthesia (TIVA) when combined with ketamine or midazolam constant rate infusions and to assess recovery quality in healthy dogs.Prospective, blinded clinical study.A group of 33 healthy, client-owned dogs subjected to dental procedures.After premedication with intramuscular acepromazine 0.05 mg kg⁻¹ and methadone 0.3 mg kg⁻¹, a ...
DOI:
10.1016/j.vaa.2019.10.010