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1. Callicarpa nudiflora Hook. & Arn.: A comprehensive review of its phytochemistry and pharmacology

Author:
Yang, Ying; Li, Zhong-Yuan; Shao, Jun-Jing; Wang, Gang; Wen, Rou; Tian, Jing-Zhen; Hou, Lin
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113123
ISSN:
0378-8741
Subject:
iridoid glycosides,   etc   ; Callicarpa nudiflora; Oriental traditional medicine; aerial parts; antioxidant activity; antiviral properties; cytotoxicity; databases; diterpenoids; essential oils; flavonoids; hepatoprotective effect; memory; neoplasm cells; nitric oxide; phenylpropanoids; platelet aggregation; shrubs; triterpenoids; China;     Show all 20 Subjects
Abstract:
... Callicarpa nudiflora Hook. & Arn. is a perennial evergreen shrub or low arbor in the Genus Callicarpa. Its dried aerial parts are used as traditional Chinese herbal medicine, Luo-hua-zi-zhu (Callicarpa nudiflora), which has been widely used in anti-bacteria and anti-ulcer in China (Commission, 2015; Development, 1994; Ming-Sheng, 2008).The present paper reviewed findings in phytochemistry and phar ...
DOI:
10.1016/j.jep.2020.113123

2. Chemical constituents of Uncaria rhynchophylloides How and their chemotaxonomic significance

Author:
Wang, Yun; Fang, Yin-Dong; Su, Jie-Li; Li, Rong-Sheng; Wang, Fei; Wang, Kou
Source:
Biochemical systematics and ecology 2020 v.91 pp. 104051
ISSN:
0305-1978
Subject:
iridoid glycosides,   etc   ; Uncaria; aerial parts; alkaloids; benzoic acid; chemical composition; chemotaxonomy; ethanol; flavonoids; phenylpropanoids; spectral analysis;     Show all 11 Subjects
Abstract:
... One undescribed 1,4-diazaindan-type alkaloid, namely howlumine (1), along with seventeen known compounds, including a known analogue, agrocybenine (2), three iridoid glycosides (3–5), four megastigmane glycosides (6–9), two benzoic acid derivatives (10–11), two phenylpropanoids (12–13), and five flavonoids (14–18), were isolated from the 95% EtOH extract of the aerial parts of Uncaria rhynchophyll ...
DOI:
10.1016/j.bse.2020.104051

3. Linaburiosides A−D, acylated iridoid glucosides from Linaria buriatica

Author:
Niwa, Kanji; Yi, Ren; Tanaka, Naonobu; Kitaguchi, Shindai; Tsuji, Daisuke; Kim, Sang-Yong; Tsogtbaatar, Ariuntuya; Bunddulam, Perleidulam; Kawazoe, Kazuyoshi; Kojoma, Mareshige; Damdinjav, Davaadagva; Itoh, Kohji; Kashiwada, Yoshiki
Source:
Phytochemistry 2020 v.171 pp. 112247
ISSN:
0031-9422
Subject:
iridoid glycosides,   etc   ; Linaria; aerial parts; glucosides; herbal medicines; moieties; spectral analysis;     Show all 7 Subjects
Abstract:
... Four previously undescribed acylated iridoid glucosides, linaburiosides A‒D, one undescribed iridoid, 7-deoxyiridolactonic acid, and one known acylated iridoid glucoside, iridolinarin C, were isolated from the aerial parts of a Mongolian traditional herbal medicine, Linaria buriatica. Linaburiosides A‒D had an acyl moiety corresponding to 7-deoxyiridolactonic acid. Detailed spectroscopic analyses ...
DOI:
10.1016/j.phytochem.2019.112247

4. “Quantity-effect” research strategy for comparison of antioxidant activity and quality of Rehmanniae Radix and Rehmannia Radix Praeparata by on-line HPLC-UV-ABTS assay

Author:
Li, Hong-Ying; Fang, Jiang-Ji; Shen, Hua-Dan; Zhang, Xue-Qiong; Ding, Xiao-Ping; Liu, Jun-Feng
Source:
BMC complementary medicine and therapies 2020 v.20 no.1 pp. 16
ISSN:
2662-7671
Subject:
iridoid glycosides,   etc   ; Rehmannia; antioxidant activity; chromatography; equations; free radical scavengers; herbal medicines; herbs; mass spectrometry; research planning; sulfonic acids; verbascoside;     Show all 12 Subjects
Abstract:
... BACKGROUND: Quantitation analysis and chromatographic fingerprint of multi-components are frequently used to evaluate quality of herbal medicines but fail to reveal activity of the components. It is necessary to develop a rational approach of chromatography coupled with activity detection for quality assessment of herbal medicines. METHODS: An on-line HPLC-ultraviolet detection-2,2′-azino-bis(3-et ...
DOI:
10.1186/s12906-019-2798-8
PubMed:
32020888
PubMed Central:
PMC7076824

5. Chemical components, pharmacological actions, and clinical applications of Rhizoma Picrorhizae

Author:
Guo, Ning; Jin, Cheng; Shen, Lan; Wu, Fei; Lin, Xiao; Feng, Yi
Source:
Phytotherapy research 2020 v.34 no.5 pp. 1071-1082
ISSN:
0951-418X
Subject:
iridoid glycosides,   etc   ; Oriental traditional medicine; active ingredients; cucurbitacins; databases; epilepsy; hepatitis B; liver; malnutrition; medicinal plants; pharmacology; rhizomes;     Show all 12 Subjects
Abstract:
... Rhizoma Picrorhizae (RP) is a traditional Chinese medicine, which has always been used to treat many diseases like infantile epilepsy and malnutrition. In modern applications, it has been used to treat hepatitis B and various liver injuries with remarkable curative effects. So far, more than 90 chemical components have been reported in RP, mainly including iridoid glycosides, cucurbitacins, phenyl ...
DOI:
10.1002/ptr.6591

6. Neuroprotective terpenoids from the leaves of Viburnum odoratissimum

Author:
Zhang, Yan; Zhou, Wei-Yu; Song, Xiao-Yu; Yao, Guo-Dong; Song, Shao-Jiang
Source:
Natural product research 2020 v.34 no.10 pp. 1352-1359
ISSN:
1478-6427
Subject:
iridoid glycosides,   etc   ; Viburnum odoratissimum; Western blotting; apoptosis; chemical structure; human cell lines; leaves; neuroprotective effect; nuclear magnetic resonance spectroscopy; spectral analysis;     Show all 10 Subjects
Abstract:
... As a part of our ongoing search for neuroprotective compounds from natural products, two new iridoid glycosides, vibsansuspenside A-B (1-2), along with five known terpenoids (3-7), were isolated from the dry leaves of Viburnum odoratissimum. Their chemical structures were well determined by means of NMR spectroscopic data as well as HRESIMS analysis. All compounds were detected for their neuroprot ...
DOI:
10.1080/14786419.2018.1514400

7. Iridoid, phenylethanoid and flavonoid glycosides from Forsythia suspensa

Author:
Wei, Qian; Zhang, Rong; Wang, Qin; Yan, Xin Jia; Yu, Quan Wei; Yan, Fu Xia; Li, Chang; Pei, Yue Hu
Source:
Natural product research 2020 v.34 no.9 pp. 1320-1325
ISSN:
1478-6427
Subject:
iridoid glycosides,   etc   ; Forsythia suspensa; Influenza A virus; antiviral properties; bioactive compounds; flavonoids; fruits; influenza; monoterpenoids; natural resources; nuclear magnetic resonance spectroscopy; spectral analysis; viruses;     Show all 13 Subjects
Abstract:
... As part of our continuing efforts to explore bioactive compounds from natural resources, a new iridoid glycoside, adoxosidic acid-6′-oleuroperic ester (1), together with one known phenylethanoid glycoside (2) and two known flavonoid glycosides (3–4) were isolated from the fruit of Forsythia suspensa. The structure of the new compound (1) was elucidated through 1D and 2D NMR spectroscopic data and ...
DOI:
10.1080/14786419.2018.1560288

8. Comprehensive separation of iridoid glycosides and triterpenoid saponins from Dipsacus asper with salt‐containing solvent by high‐speed countercurrent chromatography coupled with recycling mode

Author:
Yu, Jinqian; Zhang, Jinqiang; Sun, Xiaowei; Xiao, Chenghong; Wang, Xiao; Zhou, Tao
Source:
Journal of separation science 2020 v.43 no.7 pp. 1265-1274
ISSN:
1615-9306
Subject:
iridoid glycosides,   etc   ; Dipsacus; Oriental traditional medicine; active ingredients; bones; countercurrent chromatography; ethanol; isomers; kidneys; liver; muscles; porous media; roots; solvents; triterpenoid saponins;     Show all 15 Subjects
Abstract:
... The roots of Dipsacus asper Wall as a commonly used traditional Chinese medicine are used for tonifying liver and kidney and strengthening bones and muscles. However, an effective separation strategy for comprehensive and rapid separation of the main active compounds from the roots of D. asper is nonexistent. This investigation provided an effective separation method based on AB‐8 macroporous resi ...
DOI:
10.1002/jssc.201901186

9. Comprehensive analysis of the chemical constituents in sulfur-fumigated Lonicerae Japonicae Flos using UHPLC-LTQ-Orbitrap mass spectrometry

Author:
LIU, Zi-Han; WANG, Yu-Qi; MEI, Xiao-Dan; WANG, Fei; YANG, Xian-Zhao; LI, Xiao-Dong; JIANG, Feng; ZHANG, Jia-Yu
Source:
Chinese journal of natural medicines 2020 v.18 no.2 pp. 148-160
ISSN:
1875-5364
Subject:
iridoid glycosides,   etc   ; Oriental traditional medicine; chemical composition; chlorogenic acid; esterification; flavonoids; fumigation; heat; high performance liquid chromatography; mass spectrometry; quality control; sulfates; sulfites; sulfur; ultra-performance liquid chromatography;     Show all 15 Subjects
Abstract:
... Lonicerae Japonicae Flos (LJF), a kind of traditional Chinese medicines (TCMs), has functions of detoxifying and evacuating heat. In the study, a method based on ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry (UHPLC-LTQ-Orbitrap MS) was developed for the chemical constituent analysis of organic acids, flavonoids, iridoids and new-generated comp ...
DOI:
10.1016/S1875-5364(20)30015-7

10. Iridoids from Vitex negundo var. heterophylla and their antioxidant activities

Author:
Niu, Ying-Xue; Wang, Dun; Chu, Xin-Yue; Gao, Su-Yu; Yang, Dong-Xin; Chen, Li-Xia; Li, Hua
Source:
Phytochemistry letters 2020 v.35 pp. 186-190
ISSN:
1874-3900
Subject:
iridoid glycosides,   etc   ; 2,2-diphenyl-1-picrylhydrazyl; Vitex negundo; antioxidant activity; ethanol; free radicals; inhibitory concentration 50; leaves; plant extracts; spectral analysis;     Show all 10 Subjects
Abstract:
... Two new iridoids (1-2) together with eight known iridoid glycosides (3-10) were isolated from the 70% EtOH extract of the dried leaves of Vitex negundo var. heterophylla. Their structures were elucidated by extensive spectroscopic analyses. Iridoid aglycones were found for the first time from this plant. All of these compounds were tested for their antioxidant activities. Among them, compound 9 sh ...
DOI:
10.1016/j.phytol.2019.11.018

11. Towards eco‐friendly secondary plant metabolite quantitation: Ultra high performance supercritical fluid chromatography applied to common vervain (Verbena officinalis L.)

Author:
Gibitz‐Eisath, Nora; Eichberger, Miriam; Gruber, Regina; Seger, Christoph; Sturm, Sonja; Stuppner, Hermann
Source:
Journal of separation science 2020 v.43 no.4 pp. 829-838
ISSN:
1615-9306
Subject:
iridoid glycosides,   etc   ; Verbena officinalis; carbon dioxide; diodes; flavonoids; methanol; phosphoric acid; reversed-phase liquid chromatography; secondary metabolites; supercritical fluid chromatography; ultra-performance liquid chromatography; verbascoside;     Show all 12 Subjects
Abstract:
... This report presents the first ultra high performance supercritical fluid chromatography diode array detector based assay for simultaneous determination of iridoid glucosides, flavonoid glucuronides, and phenylpropanoid glycosides in Verbena officinalis (Verbenaceae) extracts. Separation of the key metabolites was achieved in less than 7 min on an Acquity UPC² Torus Diol column using a mobile phas ...
DOI:
10.1002/jssc.201900854
PubMed:
31769179
PubMed Central:
PMC7160600

12. Guided isolation of new iridoid glucosides from Anarrhinum pubescens by high-performance thin-layer chromatography-acetylcholinesterase assay

Author:
Mahran, Ehab; Morlock, Gertrud E.; Keusgen, Michael
Source:
Journal of chromatography 2020 v.1609 pp. 460438
ISSN:
0021-9673
Subject:
iridoid glycosides,   etc   ; Alzheimer disease; Anarrhinum; acetylcholinesterase; chemical composition; enzyme inhibitors; mass spectrometry; metabolites; neurodegenerative diseases; neuroprotective effect; nuclear magnetic resonance spectroscopy; screening; spectral analysis; thin layer chromatography;     Show all 14 Subjects
Abstract:
... Plants are an important source of natural iridoids. This study demonstrates for the first time the acetylcholinesterase (AChE) inhibitory activity of iridoids belonging to the class of antirrhinosides. As iridoids distinguish the chemical composition of most species of the Plantaginaceae family, the active AChE inhibitors were investigated in the hydro-alcoholic extract of Anarrhinum pubescens Fre ...
DOI:
10.1016/j.chroma.2019.460438

13. Acylated iridoid glycosides with hyaluronidase inhibitory activity from the rhizomes of Picrorhiza kurroa Royle ex Benth

Author:
Morikawa, Toshio; Nakanishi, Yusuke; Inoue, Naoki; Manse, Yoshiaki; Matsuura, Hideyuki; Hamasaki, Shinya; Yoshikawa, Masayuki; Muraoka, Osamu; Ninomiya, Kiyofumi
Source:
Phytochemistry 2020 v.169 pp. 112185
ISSN:
0031-9422
Subject:
iridoid glycosides,   etc   ; Picrorhiza kurrooa; anti-allergic agents; enzyme inhibition; fumarates; hyaluronoglucosaminidase; inhibitory concentration 50; methanol; nuclear magnetic resonance spectroscopy; rhizomes; stereochemistry;     Show all 11 Subjects
Abstract:
... Seven new acylated iridoid glycosides, picrorhizaosides A–G (1–7), were isolated from the methanol extract of the rhizomes of Picrorhiza kurroa Royle ex Benth. (Plantaginaceae), in addition to six known iridoid glycosides (8–13). The structures of these new iridoids, including their stereochemistry, were determined based on chemical and physicochemical evidence derived from NMR and MS analysis. Of ...
DOI:
10.1016/j.phytochem.2019.112185

14. New iridoid glycosides from Viburnum punctatum

Author:
Gao, Yuan; Yang, Wan-Qiu; Yang, Ku; Jiang, Xian-Jun; Li, Xiang-Mei; Wang, Fei
Source:
Phytochemistry letters 2018 v.28 pp. 145-148
ISSN:
1874-3900
Subject:
iridoid glycosides,   etc   ; Viburnum; glucose; moieties; spectral analysis;     Show all 5 Subjects
Abstract:
... Three hitherto unknown valeriana-type iridoid glycosides (1−3) were isolated from Viburnum punctatum, and their structures were elucidated by extensive spectroscopic analysis. The new compounds, designated as viburpunosides A − C (1−3), are characterized by having a mono- or triacylated α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranosyl moiety linked to C-11. This is the second report of an iridoid atta ...
DOI:
10.1016/j.phytol.2018.10.010

15. The polymer iridoid glucosides isolated from Dipsacus asper

Author:
Duan, Xiao-Yan; Ai, Lun-Qiang; Qian, Cheng-Zhen; Zhang, Mei-De; Mei, Ren-Qiang
Source:
Phytochemistry letters 2019 v.33 pp. 17-21
ISSN:
1874-3900
Subject:
iridoid glycosides,   etc   ; Dipsacus; anti-inflammatory activity; glucosides; nuclear magnetic resonance spectroscopy; polymers;     Show all 6 Subjects
Abstract:
... Two new iridoid tetramers with four glucosides, dipsanosides H (1) and I (2), as well as one new bis-iridoid glucosides dipsanosides J (3), along with four known polymer iridoid glycosides dipsanosides A (4) and B (5), pterocephaline (6), triplostoside A (7) were isolated from Dipsacus asper. Their structures were determined by analysis of 1D and 2D NMR data. All of them were found to be inactive ...
DOI:
10.1016/j.phytol.2019.07.001

16. Devil's claw (Harpagophytum procumbens) and chronic inflammatory diseases: A concise overview on preclinical and clinical data

Author:
Menghini, Luigi; Recinella, Lucia; Leone, Sheila; Chiavaroli, Annalisa; Cicala, Carla; Brunetti, Luigi; Vladimir‐Knežević, Sanda; Orlando, Giustino; Ferrante, Claudio
Source:
Phytotherapy research 2019 v.33 no.9 pp. 2152-2162
ISSN:
0951-418X
Subject:
iridoid glycosides,   etc   ; Harpagophytum procumbens; clinical trials; fever; indigestion; inflammation; reference standards; rheumatoid arthritis; therapeutics; traditional medicine;     Show all 10 Subjects
Abstract:
... Devil's Claw is a traditional medicine that has been long used a wide range of health conditions, including indigestion, fever, allergic reactions, and rheumatism. The main compounds are iridoid glycosides, including harpagoside, harpagide, and procumbide. However, harpagoside is the most responsible for therapeutic activity, and its content is used as reference standard. Here, we analyzed and sum ...
DOI:
10.1002/ptr.6395

17. Synanthropic Plants as an Underestimated Source of Bioactive Phytochemicals: A Case of Galeopsis bifida (Lamiaceae)

Author:
Olennikov, Daniil N.
Source:
Plants 2020 v.9 no.11
ISSN:
2223-7747
Subject:
iridoid glycosides,   etc   ; Galeopsis bifida; aerial parts; carotenes; chemotaxonomy; flavones; flowers; free radicals; glucosides; hemp; high performance liquid chromatography; leaves; metabolites; metabolomics; oxygen radical absorbance capacity; phenylpropanoids; plant extracts; superoxide anion; synanthropes; toxicity; Siberia;     Show all 21 Subjects
Abstract:
... Hemp nettle (Galeopsis bifida Boenn.) is a synanthropic species of the Lamiaceae family that is widely distributed across Europe, Asia, and Siberia. Galeopsis bifida is deeply embedded in the ethnomedical tradition of Asian healers; however, this plant is still poorly characterized, both chemically and pharmacologically. To study Siberian populations of G. bifida, we used high-performance liquid c ...
DOI:
10.3390/plants9111555

18. Inhibition of the pro-inflammatory mediators in rat neutrophils by shanzhiside methyl ester and its acetyl derivative isolated from Barleria prionitis

Author:
Ghule, B.V.; Kotagale, N.R.; Patil, K.S.
Source:
Journal of ethnopharmacology 2020 v.249 pp. 112374
ISSN:
0378-8741
Subject:
iridoid glycosides,   etc   ; Barleria; Prionitis; aerial parts; drugs; elastase; enzyme-linked immunosorbent assay; gelatinase B; interleukin-8; lipopolysaccharides; myeloperoxidase; neutrophils; quality control; quantitative analysis; rats; therapeutics; thin layer chromatography; traditional medicine; tumor necrosis factor-alpha;     Show all 19 Subjects
Abstract:
... The aerial parts of Barleria prionitis Linn. (BP) (Acanthaceae) plant has long been used to treat inflammatory disorders such as toothache, swellings, arthritis and gout.The purpose of this study was to evaluate the effects of shanzhiside methyl ester (SME), 8-O-acetyl shanzhiside methyl ester (ASME) and iridoid glycosides rich monoterpenoidal fraction (IFBp), isolated from the aerial part of BP, ...
DOI:
10.1016/j.jep.2019.112374

19. Sweroside promotes osteoblastic differentiation and mineralization via interaction of membrane estrogen receptor-α and GPR30 mediated p38 signalling pathway on MC3T3-E1 cells

Author:
Wu, Qing-chang; Tang, Xi-yang; Dai, Zi-qin; Dai, Yi; Xiao, Hui-hui; Yao, Xin-sheng
Source:
Phytomedicine 2020 v.68 pp. 153146
ISSN:
0944-7113
Subject:
iridoid glycosides,   etc   ; G-protein coupled receptors; Western blotting; alizarin; alkaline phosphatase; antagonists; bones; estrogens; extracellular fluids; fluorescent antibody technique; human diseases; mineralization; muscles; osteoblasts; osteoporosis; osteosarcoma; phosphorylation; protective effect; protein synthesis; signal transduction; spectroscopy; staining; China;     Show all 23 Subjects
Abstract:
... Dipsaci Radix has been clinically used for thousands of years in China for strengthening muscles and bones. Sweroside is the major active iridoid glycoside isolated from Dipsaci Radix. It has been reported that sweroside can promote alkaline phosphatase (ALP) activity in both the human osteosarcoma cell line MG-63 and rat osteoblasts. However, the underlying mechanism involved in these osteoblasti ...
DOI:
10.1016/j.phymed.2019.153146

20. Undescribed morroniside-like secoiridoid diglycosides with α-glucosidase inhibitory activity from Corni Fructus

Author:
Ye, Xian-Sheng; He, Jun; Xu, Jie-Kun; He, Xiao-Li; Xia, Cong-Yuan; Yan, Yu; Lian, Wen-Wen; Zhang, Wei-Ku
Source:
Phytochemistry 2020 v.171 pp. 112232
ISSN:
0031-9422
Subject:
iridoid glycosides,   etc   ; Cornus officinalis; Oriental traditional medicine; Saccharomyces cerevisiae; acarbose; alpha-glucosidase; chemical structure; electrospray ionization mass spectrometry; enzyme inhibition; fruits; glycemic effect; inhibitory concentration 50; nuclear magnetic resonance spectroscopy; phytochemicals; spectral analysis; wines;     Show all 16 Subjects
Abstract:
... Corni Fructus, also known as the fruit of Cornus officinalis Sieb. et Zucc., has long been used as a traditional Chinese medicine and is widely consumed as a nutritional food in the form of function drink and wine. Recently, Corni Fructus has attracted considerable interest because of its anti-diabetic effects. A systematic phytochemical investigation of Corni Fructus was performed to find anti-di ...
DOI:
10.1016/j.phytochem.2019.112232