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1. Leptin and IGF1 receptors in alpaca (Vicugna pacos) ovaries

Author:
Gallelli, M.F.; Bianchi, C.; Lombardo, D.; Rey, F.; Rodriguez, F.M.; Castillo, V.A.; Miragaya, M.
Source:
Animal reproduction science 2019 v.200 pp. 96-104
ISSN:
0378-4320
Subject:
leptin; leptin receptors,   etc   ; Vicugna pacos; alpacas; corpus luteum; follicular development; gonadotropins; granulosa cells; insulin; ovulation; somatomedins; steroid hormones;     Show all 12 Subjects
Abstract:
... Folliculogenesis and ovulation are regulated by gonadotrophins and other factors such as Insulin like growth factor 1 (IGF1) and leptin. In various species the presence of IGF1 receptor (IGF1R) and leptin receptor (ObR) has been detected in the ovary, but not in the alpaca. Thus, the aim of the present study was to evaluate the presence of these receptors in this tissue and analyze if the presence ...
DOI:
10.1016/j.anireprosci.2018.12.001

2. Correction to: Mapping of leptin and its syntenic genes to chicken chromosome 1p

Author:
Seroussi, Eyal; Pitel, Frédérique; Leroux, Sophie; Morisson, Mireille; Bornelöv, Susanne; Miyara, Shoval; Yosefi, Sara; Cogburn, LarryA.; Burt, DavidW.; Andersson, Leif; Friedman-Einat, Miriam
Source:
BMC genetics 2017 v.18 no.1 pp. 113
ISSN:
1471-2156
Subject:
leptin,   etc   ; chickens; chromosomes; genes;     Show all 4 Subjects
Abstract:
... CORRECTION: After the publication of this work [1] an error was noticed in one of the author surnames. The author name Leif Anderson should be spelt as Leif Andersson. ...
DOI:
10.1186/s12863-017-0587-2

3. Immunolocalization of Leptin and its Receptor (ObR-b) in Equine Placenta at Term and Plasma Level Measurement in the Late Gestation

Author:
Pazinato, Fernanda Maria; Curcio, Bruna da Rosa; Varela Junior, Antonio Sergio; Corcini, Carine Dahl; Wendt, Camila Gervini; Moreira, Fabiana; Schmit, Rubia Alves; Nogueira, Carlos Eduardo Wayne
Source:
Journal of equine veterinary science 2019 v.78 pp. 1-5
ISSN:
0737-0806
Subject:
leptin; leptin receptors,   etc   ; autocrine signaling; blood sampling; cytoplasm; epithelial cells; epithelium; fluorescent antibody technique; foaling; humans; mares; placenta; pregnancy; radioimmunoassays; rodents; staining;     Show all 16 Subjects
Abstract:
... Placental tissues from humans, rodents, and farm animal contain leptin and its receptor. Expression of leptin has already been described in horses, although there is no description about immunolocalization of leptin and its receptor. The aim of the present study was to investigate the presence and distribution of leptin and ObR-b in the equine placenta at term by immunofluorescence staining, and t ...
DOI:
10.1016/j.jevs.2019.03.008

4. A novel leptin receptor antagonist uncouples leptin’s metabolic and immune functions

Author:
Zabeau, Lennart; Wauman, Joris; Dam, Julie; Van Lint, Sandra; Burg, Elianne; De Geest, Jennifer; Rogge, Elke; Silva, Anisia; Jockers, Ralf; Tavernier, Jan
Source:
Cellular and molecular life sciences 2019 v.76 no.6 pp. 1201-1214
ISSN:
1420-682X
Subject:
leptin; leptin receptors,   etc   ; Camelidae; adverse effects; antagonists; antibodies; atrophy; autoimmune diseases; biochemical pathways; energy; epidermal growth factor receptors; immune response; mutants; neoplasms; phosphorylation; reproduction; signal transduction; weight gain;     Show all 18 Subjects
Abstract:
... Leptin links body energy stores to high energy demanding processes like reproduction and immunity. Based on leptin’s role in autoimmune diseases and cancer, several leptin and leptin receptor (LR) antagonists have been developed, but these intrinsically lead to unwanted weight gain. Here, we report on the uncoupling of leptin’s metabolic and immune functions based on the cross talk with the epider ...
DOI:
10.1007/s00018-019-03004-9

5. Leptin induced in vitro development of ovarian follicles in sheep is related to the expression of P450 aromatase and steroidogenesis

Author:
Kumar, P. Anil; Sivakumar, A.V.N.; Pathipati, Deepa; Chakravarthi, V. Praveen; Brahmaiah, K.V.; Rao, V.H.
Source:
Theriogenology 2019 v.136 pp. 1-6
ISSN:
0093-691X
Subject:
leptin,   etc   ; aromatase; culture media; estradiol; genes; oocytes; ovarian follicles; progesterone; sheep; steroidogenesis;     Show all 10 Subjects
Abstract:
... The objective of this study was to test the hypothesis that Leptin induced in vitro growth in preantral follicles in sheep involves modulation of P450 aromatase expression and steroidogenesis. Accordingly, the expression of P450 aromatase gene was studied in the cumulus cells and oocytes isolated from different stages of preantral follicles (PFs') grown in vivo, cultured in TCM 199B, TCM 199B + Le ...
DOI:
10.1016/j.theriogenology.2019.06.017

6. Involvement of the hepatic branch of the vagus nerve in the regulation of plasma adipokine levels in rats fed a high-fructose diet

Author:
Hashimoto, Naoto; Wakagi, Manabu; Ippoushi, Katsunari; Takano-Ishikawa, Yuko
Source:
The Journal of nutritional biochemistry 2019 v.71 pp. 90-97
ISSN:
0955-2863
Subject:
leptin,   etc   ; adiponectin; blood; glucose tolerance tests; high fructose diet; insulin; liver; rats; vagus nerve;     Show all 9 Subjects
Abstract:
... High-fructose diets are associated with not only fat accumulation in liver but also blood adipokine levels. Some studies have shown the involvement of humoral factors in the regulation of adipokines. However, the role of the vagus nerve in expression of adipokines is not fully understood. We attempted to investigate the involvement of the hepatic branch of the vagus nerve (HBVN) in the regulation ...
DOI:
10.1016/j.jnutbio.2019.06.003

7. Fluid Restriction Decreases Solid Food Consumption Post-Exercise

Author:
Pérez-Luco, Cristian; Díaz-Castro, Francisco; Jorquera, Carlos; Troncoso, Rodrigo; Zbinden-Foncea, Hermann; Johannsen, Neil M; Castro-Sepulveda, Mauricio
Source:
Nutrients 2019 v.11 no.6
ISSN:
2072-6643
Subject:
leptin,   etc   ; anorexia; blood; energy intake; exercise; food intake; ghrelin; men; peptide YY; rehydration; rodents; saliva;     Show all 12 Subjects
Abstract:
... Dehydration in rodents induces anorexia. In humans however, the role of dehydration in energy intake is controversial. This study investigated the effect of extreme fluid restriction on acute energy intake during and after exercise-induced dehydration. Eight physically active participants performed two exercise sessions to induce dehydration. After the exercise, the men were allowed to either rehy ...
DOI:
10.3390/nu11061209

8. Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making

Author:
Paslakis, Georgios; Agüera, Zaida; Granero, Roser; Sánchez, Isabel; Riesco, Nadine; Jiménez-Murcia, Susana; Fernández-García, Jose C.; Garrido-Sánchez, Lourdes; Tinahones, Francisco J.; Casanueva, Felipe F.; Baños, Rosa M.; Botella, Cristina; Crujeiras, Ana B.; Torre, Rafael de la; Fernández-Real, Jose M.; Frühbeck, Gema; Ortega, Francisco J.; Rodríguez, Amaia; Serra-Majem, Luís; Fitó, Montserrat; Menchón, José M.; Fernández-Aranda, Fernando
Source:
Molecular and cellular endocrinology 2019 pp. 110441
ISSN:
0303-7207
Subject:
leptin,   etc   ; adiponectin; anorexia nervosa; cholecystokinin; color; decision making; females; ghrelin; nicotinamide phosphoribosyltransferase; patients;     Show all 10 Subjects
Abstract:
... Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also ...
DOI:
10.1016/j.mce.2019.04.021

9. Associations of <i>ADIPOQ</i> and <i>LEP</i> Gene Variants with Energy Intake: A Systematic Review

Author:
Kroll, Caroline; Mastroeni, Silmara S.B.S.; Veugelers, Paul J.; Mastroeni, Marco F
Source:
Nutrients 2019 v.11 no.4
ISSN:
2072-6643
Subject:
leptin,   etc   ; adiponectin; databases; energy intake; energy metabolism; genes; genetic variation; systematic review; Caribbean;     Show all 9 Subjects
Abstract:
... This systematic review aims to evaluate the association of adiponectin (ADIPOQ) and leptin (LEP) gene variants with energy intake. Cross-sectional, cohort, and case–control studies that reported an association of leptin and/or adiponectin gene variants with energy intake were included in this review. Human studies without any age restrictions were considered eligible. Detailed individual sea ...
DOI:
10.3390/nu11040750

10. Serum SIRT1 is Associated with Frailty and Adipokines in Older Adults

Author:
Ma, Lina; Niu, H.; Sha, G.; Zhang, Y.; Liu, P.; Li, Y.
Source:
The journal of nutrition, health & aging 2019 v.23 no.3 pp. 246-250
ISSN:
1279-7707
Subject:
leptin,   etc   ; adiponectin; biomarkers; blood serum; cytokines; elderly; gait; inflammation; insulin; patients; phenotype; phospholipase A2; weight loss;     Show all 13 Subjects
Abstract:
... BACKGROUND: Because frailty is a major health concern among older patients, identifying frailty-related biomarkers will help in the early detection and prevention of frailty. Thus, we aimed to determine the association between circulating levels of silent mating-type information regulation 2 homolog 1 (SIRT1) and frailty. METHODS: We assessed circulating SIRT1 levels in 16 robust, 74 prefrail, and ...
DOI:
10.1007/s12603-018-1149-7

11. Does road transport influence plasma leptin concentrations in horses? Preliminary study

Author:
Kędzierski, Witold; Bełkot, Zbigniew
Source:
Annals of animal science 2018 v.18 no.1 pp. 185-193
ISSN:
2300-8733
Subject:
leptin,   etc   ; blood sampling; cortisol; geldings; mares; road transportation; secretion;     Show all 7 Subjects
Abstract:
... Transport is one of the most common stressors for horses leading to an increase in cortisol secretion. Cortisol promotes leptin synthesis and release. The aim of the study was to evaluate the effect of short transport on circulating leptin and cortisol concentrations. A total of 16 crossbred naïve horses (7 geldings, 9 mares) aged 2-11 years, and weighing 530-680 kg were included in the study. The ...
DOI:
10.1515/aoas-2017-0015

12. Targeting the leptin receptor: To evaluate therapeutic efficacy and anti-tumor effects of Doxil, in vitro and in vivo in mice bearing C26 colon carcinoma tumor

Author:
Amiri Darban, Shahrzad; Nikoofal-Sahlabadi, Sara; Amiri, Nafise; Kiamanesh, Nafiseh; Mehrabian, Amin; Zendehbad, Bamdad; Gholizadeh, Zahra; Jaafari, Mahmoud Reza
Source:
Colloids and surfaces 2018 v.164 pp. 107-115
ISSN:
0927-7765
Subject:
leptin; leptin receptors,   etc   ; adipose tissue; antineoplastic activity; appetite; blood circulation; carcinoma; colloids; colorectal neoplasms; cytotoxicity; doxorubicin; ligands; mice; models; nanocarriers;     Show all 15 Subjects
Abstract:
... Leptin is an appetite regulatory hormone that is secreted into the blood circulation by the adipose tissue and it functions via its over expressed receptors (Ob-R) in a wide variety of cancers. In the present study, the function of a leptin-derived peptide (LP16, 91–110 of Leptin) was investigated as a targeting ligand to decorate PEGylated liposomal doxorubicin (PLD, Doxil®) surface and the anti- ...
DOI:
10.1016/j.colsurfb.2018.01.035

13. Hypothalamic insulin receptor expression and DNA promoter methylation are sex-specifically altered in adult offspring of high-fat diet (HFD)-overfed mother rats

Author:
Schellong, Karen; Melchior, Kerstin; Ziska, Thomas; Ott, Raffael; Henrich, Wolfgang; Rancourt, Rebecca C.; Plagemann, Andreas
Source:
The Journal of nutritional biochemistry 2019 v.67 pp. 28-35
ISSN:
0955-2863
Subject:
leptin; leptin receptors,   etc   ; DNA; DNA methylation; adults; epigenetics; gene expression regulation; glucose; glucose tolerance; glucose transporters; high fat diet; hyperinsulinemia; insulin; insulin receptors; insulin resistance; lactation; males; metabolic syndrome; neuropeptides; obesity; phenotype; pregnancy; progeny; rats; risk; satiety;     Show all 26 Subjects
Abstract:
... Maternal overnutrition around reproduction has been shown to increase the offspring's risk for “diabesity,” mediated by altered hypothalamic neuropeptide expression. In this report, a possible contribution of altered hypothalamic sensing capacity for the peripheral satiety signals glucose, insulin and leptin will be addressed, taking into account potential sex differences. Specifically, we evaluat ...
DOI:
10.1016/j.jnutbio.2019.01.014

14. Changes in thyroid hormones, leptin, ghrelin and, galanin following oral melatonin administration in intact and castrated dogs: a preliminary study

Author:
Taheri, Pegah; Mogheiseh, Asghar; Shojaee Tabrizi, Aidin; Nazifi, Saeed; Salavati, Sina; Koohi, Farzaneh
Source:
BMC veterinary research 2019 v.15 no.1 pp. 145
ISSN:
1746-6148
Subject:
leptin,   etc   ; adverse effects; blood sampling; castration; dogs; ghrelin; jugular vein; males; melatonin; metabolism; mixed breeds; neurotransmitters; thyroid hormones;     Show all 13 Subjects
Abstract:
... BACKGROUND: Melatonin regulates metabolism and metabolism related hormones in mammalians. Castration has some adverse effects on the metabolic hormones of dog. This study was conducted to determine the effects of oral melatonin administration on metabolic hormones, as well as to compare changes of these hormones after administration of melatonin in castrated and intact dogs. Twenty healthy mixed b ...
DOI:
10.1186/s12917-019-1894-9

15. Examining weight suppression as a transdiagnostic factor influencing illness trajectory in bulimic eating disorders

Author:
Keel, Pamela K.; Bodell, Lindsay P.; Forney, K. Jean; Appelbaum, Jonathan; Williams, Diana
Source:
Physiology & behavior 2019 v.208 pp. 112565
ISSN:
0031-9384
Subject:
leptin,   etc   ; binge eating disorder; binging; bulimia nervosa; food consumption; glucagon-like peptide 1; models; motivation; risk; satiety;     Show all 10 Subjects
Abstract:
... Recent research indicates that weight suppression (WS: defined as the difference between highest lifetime and current weight) prospectively predicts illness trajectory across eating disorders characterized by binge eating, including AN binge-purge subtype (ANbp), bulimia nervosa (BN), and binge eating disorder (BED), collectively referred to as bulimic eating disorders. Through a series of studies ...
DOI:
10.1016/j.physbeh.2019.112565

16. Metabolic hormones and the regulation of spermatogenesis in fishes

Author:
Hatef, Azadeh; Unniappan, Suraj
Source:
Theriogenology 2019 v.134 pp. 121-128
ISSN:
0093-691X
Subject:
leptin,   etc   ; energy balance; fasting; fish; food deprivation; ghrelin; males; mammals; metabolism; morphogenesis; sperm quality; spermatogenesis; testes; testicular development;     Show all 14 Subjects
Abstract:
... Metabolic hormones play essential regulatory roles in many biological processes, including morphogenesis, growth, and reproduction through the maintenance of energy balance. Various metabolic hormones originally discovered in mammals, including ghrelin, leptin, and nesfatin-1 have been identified and characterized in fish. However, physiological roles of these metabolic hormones in regulating repr ...
DOI:
10.1016/j.theriogenology.2019.05.021

17. Porous graphene-black phosphorus nanocomposite modified electrode for detection of leptin

Author:
Cai, Jinying; Gou, Xiaodan; Sun, Bolu; Li, Wuyan; Li, Dai; Liu, Jinglong; Hu, Fangdi; Li, Yingdong
Source:
Biosensors & bioelectronics 2019 v.137 pp. 88-95
ISSN:
0956-5663
Subject:
leptin,   etc   ; anisotropy; biomarkers; crosslinking; cysteamine; detection limit; electrochemistry; electrodes; fatty liver; glutaraldehyde; graphene; immunosensors; nanocomposites; nanogold; phosphorus; pressing; proteins; screening;     Show all 18 Subjects
Abstract:
... Leptin is a vital biomarker of non-alcoholic fatty liver (NAFLD), and its evaluation of the concentration level in vivo is of great significance to NAFLD diagnosis. Therefore, it is pressing to develop a method for rapid and sensitive detection of leptin. This paper describes an environmentally friendly and label-free immunosensor based on porous graphene functionalized black phosphorus (PG-BP) co ...
DOI:
10.1016/j.bios.2019.04.045

18. The Preventive Effects of Greenshell Mussel (<i>Perna canaliculus)</i> on Early-Stage Metabolic Osteoarthritis in Rats with Diet-Induced Obesity

Author:
Siriarchavatana, Parkpoom; Kruger, Marlena C.; Miller, Matthew R.; Tian, Hong Sabrina; Wolber, Frances M.
Source:
Nutrients 2019 v.11 no.7
ISSN:
2072-6643
Subject:
leptin,   etc   ; Perna canaliculus; biomarkers; blood serum; cartilage; collagen; diet; meat; obesity; oils; osteoarthritis; rats; shellfish; New Zealand;     Show all 14 Subjects
Abstract:
... The prevalence of osteoarthritis (OA) is rising worldwide, with the most pronounced increase being in the category of metabolic-associated osteoarthritis (MetOA). This is predicted to worsen with the global rise in aging societies and obesity. To address this health burden, research is being conducted to identify foods that can reduce the incidence or severity of MetOA. Oil from the Greenshell mus ...
DOI:
10.3390/nu11071601

19. Role of orexin in exercise-induced leptin sensitivity in the mediobasal hypothalamus of mice

Author:
Shiuchi, Tetsuya; Miyatake, Yumiko; Otsuka, Airi; Chikahisa, Sachiko; Sakaue, Hiroshi; Séi, Hiroyoshi
Source:
Biochemical and biophysical research communications 2019 v.514 no.1 pp. 166-172
ISSN:
0006-291X
Subject:
leptin,   etc   ; antagonists; energy metabolism; exercise; hypothalamus; intraperitoneal injection; mice; mitogen-activated protein kinase; neurons; neuropeptides; phosphorylation; signal transduction; transactivators;     Show all 13 Subjects
Abstract:
... Orexin is known as an important neuropeptide in the regulation of energy metabolism. However, the role of orexin in exercise-induced leptin sensitivity in the hypothalamus has been unclear. In this study, we determined the effect of transient treadmill exercise on leptin sensitivity in the mediobasal hypothalamus (MBH) of mice and examined the role of orexin in post-exercise leptin sensitivity. Tr ...
DOI:
10.1016/j.bbrc.2019.04.145

20. Developmental toxicity by thifluzamide in zebrafish (Danio rerio): Involvement of leptin

Author:
Yang, Yang; Dong, Fengshou; Liu, Xingang; Xu, Jun; Wu, Xiaohu; Wang, Donghui; Zheng, Yongquan
Source:
Chemosphere 2019 v.221 pp. 863-869
ISSN:
0045-6535
Subject:
leptin,   etc   ; Danio rerio; cAMP-dependent protein kinase; cyclic AMP; developmental toxicity; genes; glucagon; growth and development; phosphorylation; signal transduction; somatotropin;     Show all 11 Subjects
Abstract:
... Although previous trials have indicated that thifluzamide induces developmental inhibition in zebrafish, understanding the distinct mechanism of thifluzamide in this process remains challenging. This study investigated the effect of thifluzamide on zebrafish development and the underlying related signaling pathway. Thifluzamide repressed glucagon (GC) levels but increased growth hormone (GH) level ...
DOI:
10.1016/j.chemosphere.2019.01.043