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leptin; leptin receptors, etc ; catecholamines; food intake; glucocorticoids; physiology; refeeding; Show all 7 Subjects
Abstract:
... The present review provides a comparative insight into structure, function and control of leptin system in fishes, herptiles, birds and mammals. In general, leptin acts as an anorexigenic hormone since its administration results in decrease of food intake in vertebrates. Nonetheless, functional paradox arises in fishes from contradictory observations on level of leptin during fasting and re-feedin ...
leptin; leptin receptors, etc ; alleles; fever; genotyping; haplotypes; ligases; models; pathogenesis; tuberculosis; Show all 10 Subjects
Abstract:
... The aim of our study was to investigate the association of leptin (LEP) gene (rs11761556, rs12706832, rs2167270), leptin receptor (LEPR) gene (rs1137100, rs1137101, rs1805096) variants and pulmonary tuberculosis (PTB) susceptibility, as well as their several clinical manifestations, in a Chinese population. This study included a cohort of 489 PTB patients and 489 healthy controls, and six SNPs wer ...
... Per- and polyfluoroalkyl substances (PFAS) exposure has been linked to metabolic health outcomes such as obesity, and changes in adipokine hormones may be one of the underlying biological mechanisms. We prospectively evaluated the associations between prenatal and early childhood exposures to PFASs and adipokines in children. PFAS concentrations were measured in serum samples collected at birth, 1 ...
leptin, etc ; adiponectin; gout; hyperuricemia; pleiotropy; uric acid; Show all 6 Subjects
Abstract:
... Previous observational studies have highlighted associations between adipokines and hyperuricemia, as well as gout, but the causality and direction of these associations are not clear. Therefore, we attempted to assess whether there are causal effects of specific adipokines (such as adiponectin (ADP) and soluble leptin receptors (sOB-R)) on uric acid (UA) or gout in a two-sample Mendelian randomiz ...
... Adipokines, cytokines secreted by adipose tissue, may contribute to obesity-related metabolic disease. The role of environmental phenols and parabens in racial difference in metabolic disease burden has been suggested, but there is limited evidence. We examined the cross-sectional associations of urinary phenols and parabens with adipokines and effect modification by race. Urinary concentrations o ...
Francesco Suriano; Claudia Manca; Nicolas Flamand; Clara Depommier; Matthias Van Hul; Nathalie M. Delzenne; Cristoforo Silvestri; Patrice D. Cani; Vincenzo Di Marzo
... Obesity and type 2 diabetes are two interrelated metabolic disorders characterized by insulin resistance and a mild chronic inflammatory state. We previously observed that leptin (ob/ob) and leptin receptor (db/db) knockout mice display a distinct inflammatory tone in the liver and adipose tissue. The present study aimed at investigating whether alterations in these tissues of the molecules belong ...
... Brown seaweeds, which are macroalgae, are common foods and traditional medicines for Asians. Ishige okamurae (Yendo), found in Korea's shallow coastal areas, is one of the edible and medicinal brown seaweeds. Recent studies verified the pharmacological activities of the valuable properties from brown seaweeds such as ishophloroglucin A, a phlorotannin from I. okamurae. Recently, many studies have ...
leptin, etc ; Acipenser baerii; appetite; fasting; fish; food intake; ghrelin; hypothalamus; intraperitoneal injection; Show all 9 Subjects
Abstract:
... In 1996, kiss was reported to regulate feeding in mammals, but studies are limited in fish. Our study aimed to explore the possible role of kiss in the regulation of feeding in Siberian sturgeon (Acipenser baerii). kiss1 and kiss2 were cloned, and the expression patterns were analyzed in Siberian sturgeon. The complete coding regions of kiss1 and kiss2 genes were 393 and 471 bp. Both kiss1 and kis ...
leptin; leptin receptors, etc ; adiposity; anterior pituitary; diet; euthanasia; nutritional status; preoptic area; resistin; Show all 9 Subjects
Abstract:
... The short form of the leptin receptor (LRa) plays a key role in the transport of leptin to the central nervous system (CNS). Here, the resistin (RSTN)-mediated expression of LRa in the preoptic area (POA), ventromedial and dorsomedial nuclei (VMH/DMH),arcuate nucleus (ARC) and the anterior pituitary gland (AP)was analyzed considering the photoperiodic (experiment 1) and nutritional status (experim ...
Elizabeth Marchlewicz; Carolyn McCabe; Zora Djuric; Mark Hoenerhoff; John Barks; Lu Tang; Peter X. Song; Karen Peterson; Vasantha Padmanabhan; Dana C. Dolinoy
... The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. Perinatal development is a critical window for altered, lifelong health trajectory, and evidence supports the role of perinatal programming in chronic metabolic diseases. To examine the impact of diet and bisphenol A (BPA) on the developmental trajectory of NAFLD in offspring, we exposed dams from pre-gestation th ...
leptin; leptin receptors, etc ; Rasa Aragonesa; adipose tissue; body condition; gene expression; insulin; liver; malnutrition; somatotropin receptors; Show all 10 Subjects
Abstract:
... The aim of this work was to determine the effects of undernutrition on gene expression in liver and adipose tissue, and on the hepatic concentration of insulin like growth factor 1 (IGF1) and insulin, in pregnant ewes with different initial body condition score (iBCS). Thirty-six Rasa Aragonesa ewes were divided into 2 groups with different BCS: BCS > 2.75 (n = 19; high, H) and BCS < 2.25 (n = 17; ...
... This Special Issue of Nutrients “Leptin and Metabolic Programming” includes one review article regarding the function of leptin throughout the entire life on cardiometabolic fates and four original articles related to the new function of leptin present in milk and liquid amniotic, its possible relation with other components of breast milk, and how environmental conditions may impact on leptin acti ...
leptin, etc ; absorption; energy expenditure; food consumption; food intake; genetic factors; genomics; memory disorders; neurons; neuropeptides; spatial memory; Show all 11 Subjects
Abstract:
... Food intake is generally assumed to reflect a regulatory tension between homeostatic and hedonic drivers. Information from individuals with memory dysfunction suggests that episodic memory may also play a significant role. We reasoned that if memory influences food intake, then disrupting a genetic factor that is important in episodic memory formation should affect food intake and energy balance. ...
leptin, etc ; adiponectin; breast milk; cortisol; food chemistry; glucagon-like peptide 1; high pressure treatment; insulin; milk; pasteurization; Show all 10 Subjects
Abstract:
... In human milk banks (HMBs), donor milk (DM) is commonly sterilized by Holder pasteurization (HoP). High hydrostatic pressure (HHP) processing is an innovative, alternative method for DM sterilization. We evaluated the impact of HHP processing on the concentration of seven metabolic milk hormones. Eight samples of raw DM were aliquoted. One aliquot was sterilized by HoP (62 °C for 30 min), and anot ...
leptin, etc ; blood serum; clinical nutrition; confidence interval; isoflavones; meta-analysis; models; soy protein; standard deviation; systematic review; Show all 10 Subjects
Abstract:
... Some studies conducted on soy isoflavones and soy protein reflected that leptin can be reduced by soy isoflavones or soy protein. The aim of present study is to assess the effect of soy isoflavones plus soy protein on serum concentration of leptin among adults. To find randomized clinical trails (RCTs) assessing the effect of soy isoflavones containing soy protein on serum concentration of leptin ...
leptin, etc ; appetite; cholecystokinin; docosahexaenoic acid; epithelium; food intake; high carbohydrate diet; hormone secretion; jejunum; overeating; transcriptomics; triacylglycerols; Show all 12 Subjects
Abstract:
... High-fat, high-sugar diet (HFHS) induced leptin resistance and intestinal epithelial dysfunction is implicated in hyperphagia and metabolic disorders. Numerous studies have demonstrated the efficacy of dietary interventions for reducing appetite. This study aims to investigate whether triacylglycerol rich in DHA (DHA-TG) could regulate appetite in mice fed with a HFHS diet and the mechanism by whi ...
leptin, etc ; adiposity; adults; appetite; energy balance; ewes; ghrelin; homeostasis; maternal nutrition; metabolism; necropsy; nutritional intervention; parturition; pregnancy; progeny; Show all 15 Subjects
Abstract:
... Poor maternal nutrition during gestation can negatively affect offspring growth, development, and health. Leptin and ghrelin, key hormones in energy homeostasis and appetite control, may mediate these changes. We hypothesized that restricted- and over-feeding during gestation would alter plasma concentrations of leptin and ghrelin in ewes and offspring. Pregnant ewes (n = 37) were fed 1 of 3 diets ...
leptin, etc ; cytokines; photoperiod; secretion; sheep; somatotropin; Show all 6 Subjects
Abstract:
... This study examined how leptin affects growth hormone (GH) release and investigated the effects of leptin, GH, and day length on the suppressor of cytokine signaling-3 (SOCS-3) mRNA levels in the adenohypophyses of sheep. The study consisted of two experiments. The first experiment was conducted during long (LD) and short (SD) days. Within-season and replicate sheep were centrally infused with Rin ...
Lorena Desdentado; Jaime Navarrete; María Folgado-Alufre; Ana de Blas; Jéssica Navarro-Siurana; Francisco Ponce; Guadalupe Molinari; Andrea Jimeno-Martínez; Azahara I. Rupérez; Gloria Bueno-Lozano; Aida Cuenca-Royo; Emili Corbella; Zaida Agüera; Rosa M. Baños; Julio Álvarez-Pitti
... Disturbances in eating behaviors have been widely related to obesity. However, little is known about the role of obesity-related biomarkers in shaping habitual patterns of eating behaviors (i.e., eating styles) in childhood. The objective of the present study was to explore the relationships between several biomarkers crucially involved in obesity (ghrelin, insulin resistance, and leptin/adiponect ...
leptin, etc ; abomasum; blood; energy expenditure; epithelial cells; epithelium; feed intake; ghrelin; immune response; immunohistochemistry; peroxidase; rams; satiety; smooth muscle; Show all 14 Subjects
Abstract:
... In most mammals, leptin plays central and peripheral roles in a wide range of metabolic activities including feed consumption and digestion, energy expenditure and the regulation of carbohydrate‐fat accumulation. Ghrelin is a strong appetite‐stimulating hormone, while obestatin has the opposite effect of ghrelin. The latter is released during feeding, causing a sense of satiety. This study aimed t ...