PubAg

Main content area

You searched for: Subject "leptin" Remove constraint Subject: "leptin"
Start Over

Search

3,476  Search Results

« Previous | 1 - 20 of 3,476 |
Number of results to display per page

Search Results

1. Deletion of growth hormone receptor in hypothalamic neurons affects the adaptation capacity to aerobic exercise

Author:
Pedroso, João A.B.; dos Santos, Lucas B.P.; Furigo, Isadora C.; Spagnol, Alexandre R.; Wasinski, Frederick; List, Edward O.; Kopchick, John J.; Donato, Jose
Source:
Peptides 2021 v.135 pp. 170426
ISSN:
0196-9781
Subject:
leptin receptors,   etc   ; athletic performance; blood glucose; energy expenditure; exercise; glucose tolerance; hypertrophy; hypothalamus; locomotion; males; mice; muscles; neurons; somatotropin; somatotropin receptors;     Show all 15 Subjects
Abstract:
... The hypothalamus mediates important exercise-induced metabolic adaptations, possibly via hormonal signals. Hypothalamic leptin receptor (LepR)- and steroidogenic factor 1 (SF1)-expressing neurons are directly responsive to growth hormone (GH) and deletion of GH receptor (GHR) in these cells impairs neuroendocrine responses during situations of metabolic stress. In the present study, we determined ...
DOI:
10.1016/j.peptides.2020.170426

2. Interplay of circulating leptin and obesity in cognition and cerebral volumes in older adults

Author:
Zonneveld, M.H.; Noordam, R.; van der Grond, J.; van Heemst, D.; Mooijaart, S.P.; Sabayan, B.; Jukema, J.W.; Trompet, S.
Source:
Peptides 2021 v.135 pp. 170424
ISSN:
0196-9781
Subject:
leptin,   etc   ; amygdala; at-risk population; blood serum; body mass index; cardiovascular diseases; cognition; demographic statistics; elderly; females; hippocampus; magnetic resonance imaging; obesity; pravastatin; prospective studies; regression analysis; risk factors;     Show all 17 Subjects
Abstract:
... We aimed to investigate whether circulating leptin and body mass index (BMI) associate independently with cognitive function (decline) and brain volumes using magnetic resonance imaging (MRI) in older individuals at risk of cardiovascular disease. We studied the cross-sectional and longitudinal associations in participants enrolled in the PROSPER study (Prospective Study of Pravastatin in the Elde ...
DOI:
10.1016/j.peptides.2020.170424

3. Adipokines: A gear shift in puberty

Author:
Nieuwenhuis, Desirée; Pujol‐Gualdo, Natàlia; Arnoldussen, Ilse A.C.; Kiliaan, Amanda J.
Source:
Obesity reviews 2020 v.21 no.6 pp. e13005
ISSN:
1467-7881
Subject:
leptin,   etc   ; adiponectin; boys; childhood obesity; children; girls; gonads; puberty; receptors;     Show all 9 Subjects
Abstract:
... In this review, we discuss the role of adipokines in the onset of puberty in children with obesity during adrenarche and gonadarche and provide a clear and detailed overview of the biological processes of two major players, leptin and adiponectin. Adipokines, especially leptin and adiponectin, seem to induce an early onset of puberty in girls and boys with obesity by affecting the hypothalamic‐pit ...
DOI:
10.1111/obr.13005

4. Interrelationships between metabolic hormones, leptin and ghrelin, and oil-related contaminants in control of oxytocin and prostaglandin F release by feline ovaries

Author:
Sirotkin, Alexander V.; Tarko, Adam; Kotwica, Jan; Alrezaki, Abdulkarem; Harrath, Abdel Halim
Source:
Reproductive Biology 2020 v.20 no.2 pp. 254-258
ISSN:
1642-431X
Subject:
leptin,   etc   ; animal ovaries; cats; ghrelin; oxytocin; pollution; prostaglandins; toluene; xylene;     Show all 9 Subjects
Abstract:
... We examined the effects of metabolic hormones leptin and ghrelin, and the oil-related environmental contaminants toluene and xylene on the release of ovarian hormones by gravid and non-gravid cats, as well as the functional interrelationships between metabolic hormones and contaminants. Ovarian fragments of non-gravid cats were cultured with and without leptin and toluene. Next, ovarian fragments ...
DOI:
10.1016/j.repbio.2020.02.003

5. Systemic and brain delivery of leptin via intranasal coadministration with cell-penetrating peptides and its therapeutic potential for obesity

Author:
Khafagy, El-Sayed; Kamei, Noriyasu; Fujiwara, Yui; Okumura, Haruka; Yuasa, Teruyo; Kato, Masahiro; Arime, Kenji; Nonomura, Anna; Ogino, Hideyuki; Hirano, Serena; Sugano, Sayaka; Takeda-Morishita, Mariko
Source:
Journal of controlled release 2020 v.319 pp. 397-406
ISSN:
0168-3659
Subject:
leptin; leptin receptors,   etc   ; appetite; blood-brain barrier; energy metabolism; glucose; hypothalamus; obesity; permeability; phosphorylation; surfactants; therapeutics; triacylglycerols;     Show all 13 Subjects
Abstract:
... Leptin is an endogenous hormone that regulates the appetite, energy metabolism, and glucose intake in the central nervous system (CNS) and is a potential therapeutic agent for obesity. In the normal healthy condition, peripherally secreted leptin is transported across the blood-brain barrier (BBB) to the target brain site, in particular the hypothalamus. However, it was reported that the progressi ...
DOI:
10.1016/j.jconrel.2020.01.016

6. Temporal expression profiles of leptin and its receptor genes during early development and ovarian maturation of Cynoglossus semilaevis

Author:
Wang, Bin; Cui, Aijun; Wang, Pengfei; Zhang, Yaxing; Liu, Xuezhou; Jiang, Yan; Xu, Yongjiang
Source:
Fish physiology and biochemistry 2020 v.46 no.1 pp. 359-370
ISSN:
0920-1742
Subject:
leptin; leptin receptors,   etc   ; Cynoglossus semilaevis; developmental stages; early development; eggs; embryogenesis; food intake; gene expression; genes; homeostasis; larval development; ligands; messenger RNA; reverse transcriptase polymerase chain reaction; vertebrates;     Show all 16 Subjects
Abstract:
... Leptin (Lep) plays a key role in the regulation of food intake and energy homeostasis in vertebrates. Our previous studies have provided evidence for the existence of two leptin genes (lepa and lepb) and one leptin receptor (lepr) gene in a flatfish, the half-smooth tongue sole (Cynoglossus semilaevis). However, the spatial-temporal expression patterns and possible roles of the leptin system durin ...
DOI:
10.1007/s10695-019-00722-6

7. Leptin affects the inflammatory response after STEMI

Author:
Demarchi, Andrea; Mazzucchelli, Iolanda; Somaschini, Alberto; Cornara, Stefano; Dusi, Veronica; Mirizzi, Alessandro Mandurino; Ruffinazzi, Marta; Crimi, Gabriele; Ferlini, Marco; Gnecchi, Massimiliano; Visconti, Luigi Oltrona; De Servi, Stefano; De Ferrari, Gaetano M.
Source:
Nutrition, metabolism, and cardiovascular diseases 2020 v.30 no.6 pp. 922-924
ISSN:
0939-4753
Subject:
leptin,   etc   ; appetite; blood serum; body weight; food intake; inflammation; myocardial infarction; patients; risk assessment;     Show all 9 Subjects
Abstract:
... Leptin is an adipose tissue-derived hormone primarily involved in the regulation of food intake. Leptine has been shown to have a much broader role than just regulating body weight and appetite in response to food intake: among the others, it has been associated with increased ROS production and inflammation, factors involved in the restoration of an effective myocardial reperfusion after myocardi ...
DOI:
10.1016/j.numecd.2020.02.004

8. Influence of macronutrient composition of commercial diets on circulating leptin and adiponectin concentrations in overweight dogs

Author:
Blees, Niels Roderick; Wolfswinkel, Jeannette; Kooistra, Hans Sjoerd; Corbee, Ronald Jan
Source:
Journal of animal physiology and animal nutrition 2020 v.104 no.2 pp. 698-706
ISSN:
0931-2439
Subject:
leptin,   etc   ; adiponectin; animal feeding; blood; carbohydrates; comorbidity; dogs; experimental diets; females; inflammation; males; overweight; satiety;     Show all 13 Subjects
Abstract:
... Leptin and adiponectin play important roles in obesity‐related inflammation and comorbidities. Previous research suggests that alterations in dietary macronutrient composition can modify circulating leptin and adiponectin concentrations in people, but limited research on this subject has been performed in dogs. This study investigated the effects of commercial high protein (HP), high fat (HF) and ...
DOI:
10.1111/jpn.13285
PubMed:
31880032
PubMed Central:
PMC7078794

9. Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?

Author:
Izquierdo, Andrea G.; Crujeiras, Ana B.; Casanueva, Felipe F.; Carreira, Marcos C.
Source:
Nutrients 2019 v.11 no.11
ISSN:
2072-6643
Subject:
leptin,   etc   ; food intake; hypothalamus; obesity; transportation;     Show all 5 Subjects
Abstract:
... Leptin, a hormone that is capable of effectively reducing food intake and body weight, was initially considered for use in the treatment of obesity. However, obese subjects have since been found to have high levels of circulating leptin and to be insensitive to the exogenous administration of leptin. The inability of leptin to exert its anorexigenic effects in obese individuals, and therefore, the ...
DOI:
10.3390/nu11112704
PubMed:
31717265
PubMed Central:
PMC6893721

10. Leptin gene polymorphism (rs7799039; G2548A) is associated with changes in serum lipid concentrations during pregnancy: a prospective cohort study

Author:
Farias, Dayana Rodrigues; Alves-Santos, Nadya Helena; Eshriqui, Ilana; Martins, Maisa Cruz; Struchiner, Cláudio J.; Lepsch, Jaqueline; Costa, Nathalia; Kac, Gilberto
Source:
European journal of nutrition 2020 v.59 no.5 pp. 1999-2009
ISSN:
1436-6207
Subject:
leptin; leptin receptors,   etc   ; DNA; alleles; blood lipids; cholesterol; cohort studies; colorimetry; energy intake; food intake; genotyping; homozygosity; lipid content; models; pregnancy; pregnant women; quantitative polymerase chain reaction; sample size; single nucleotide polymorphism; statistical analysis; triacylglycerols; Brazil;     Show all 22 Subjects
Abstract:
... PURPOSE: Little is known about the effects of leptin and leptin receptor polymorphisms on lipid changes during pregnancy. The aims of this study were to evaluate the associations between the single nucleotide polymorphisms (SNPs) of leptin and leptin receptor genes and the lipid concentrations during pregnancy; and to test whether dietary intake is a mediator in these associations. METHODS: A pros ...
DOI:
10.1007/s00394-019-02049-7

11. Long-term abuse of a high-carbohydrate diet is as harmful as a high-fat diet for development and progression of liver injury in a mouse model of NAFLD/NASH

Author:
Pompili, Simona; Vetuschi, Antonella; Gaudio, Eugenio; Tessitore, Alessandra; Capelli, Roberta; Alesse, Edoardo; Latella, Giovanni; Sferra, Roberta; Onori, Paolo
Source:
Nutrition 2020 v.75-76 pp. 110782
ISSN:
0899-9007
Subject:
leptin; leptin receptors,   etc   ; animal models; carbohydrates; fatty liver; fibrosis; high carbohydrate diet; high fat diet; immunohistochemistry; inflammation; liver; metabolic syndrome; mice; quantitative polymerase chain reaction; transforming growth factor beta 1; triacylglycerols;     Show all 16 Subjects
Abstract:
... Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease globally. It is caused by a complex network of factors, including diet. The hallmark of NAFLD is the benign accumulation of triacylglycerols, however, this condition may worsen into non-alcoholic steatohepatitis (NASH), a more severe form associated with inflammation and fibrosis. Currently, no therapies are availab ...
DOI:
10.1016/j.nut.2020.110782

12. Effect of breed body-size on leptin amniotic fluid concentrations at term pregnancy in dogs

Author:
Veronesi, M.C.; Fusi, J.; Comin, A.; Ferrario, P.G.; Bolis, B.; Prandi, A.
Source:
Theriogenology 2020 v.149 pp. 1-5
ISSN:
0093-691X
Subject:
leptin; leptin receptors,   etc   ; adults; amniotic fluid; birth weight; bitches; body size; breeds; cesarean section; dystocia; enzyme-linked immunosorbent assay; fetal development; free fatty acids; homeostasis; humans; insulin-like growth factor I; litter size; metabolism; pregnancy; puppies; purebreds; risk;     Show all 22 Subjects
Abstract:
... Because of the need to improve the knowledge about canine perinatology, and given the major role of fetal fluids in sustaining the course of pregnancy and fetal development, an in-depth analysis to better understand the role of some hormones in these compartments is essential. Among all, leptin is recognized to play a key role not only on the energetic homeostasis, but also at multiple levels, inf ...
DOI:
10.1016/j.theriogenology.2020.03.021

13. Differential effects of leptin administration on feeding and HPT axis function in early-life overfed adult rats

Author:
de Gortari, P.; Alcántara-Alonso, V.; Matamoros-Trejo, G.; Amaya, M.I.; Alvarez-Salas, E.
Source:
Peptides 2020 v.127 pp. 170285
ISSN:
0196-9781
Subject:
leptin; leptin receptors,   etc   ; ad libitum feeding; adults; blood serum; energy expenditure; food intake; gene expression; homeostasis; laboratory animals; lactation; males; messenger RNA; metabolism; obesity; overeating; overfeeding; rats; rearing; therapeutics; thyrotropin-releasing hormone; weaning;     Show all 22 Subjects
Abstract:
... Early-life overfeeding (OF) disrupts neuroendocrine systems, energy homeostasis and food intake regulation inducing overeating and overweight in adults. Adult rats raised in small litters during lactation, display hyperphagia and overweight since weaning and exhibit a decrease in thyrotropin-releasing hormone (TRH) mRNA expression in hypothalamic paraventricular nucleus (PVN). This is counterintui ...
DOI:
10.1016/j.peptides.2020.170285

14. Bisphenols B, E, F, and S and 4‐cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A

Author:
Ramskov Tetzlaff, Cecilie N.; Svingen, Terje; Vinggaard, Anne M.; Rosenmai, Anna K.; Taxvig, Camilla
Source:
Environmental toxicology 2020 v.35 no.5 pp. 543-552
ISSN:
1520-4081
Subject:
leptin,   etc   ; adipocytes; adipogenesis; bisphenol A; bisphenol B; bisphenol E; bisphenol F; bisphenol S; human health; lipids; mice;     Show all 11 Subjects
Abstract:
... Bisphenol A (BPA) has been widely reported to exert endocrine disrupting effects, including the induction of adipogenesis in cultured preadipocytes and intact animals. Because of the potential harm to human health, BPA is being substituted by structurally related bisphenols. Whether or not such BPA analogues are safe substitutes, however, remains largely unknown. Here, we investigated the potentia ...
DOI:
10.1002/tox.22889

15. Genetic polymorphism association analysis of SNPs on the species conservation genes of Tan sheep and Hu sheep

Author:
EEr, Hehua; Ma, Lina; Xie, Xiulan; Ma, Jifeng; Ma, Xiaoming; Yue, Caijuan; Ma, Qing; Liang, Xiaojun; Ding, Wei; Li, Yingkang
Source:
Tropical animal health and production 2020 v.52 no.3 pp. 915-926
ISSN:
0049-4747
Subject:
leptin,   etc   ; genes; genetic markers; genetic models; genetic variation; growth traits; haplotypes; loci; meat; reproduction; sheep; single nucleotide polymorphism;     Show all 12 Subjects
Abstract:
... For further understanding the genetic control mechanisms of growth and development in Tan sheep, and culturing good traits on meat performance, which is very important to both in developing local species and improving economic efficaciously. In our study, we recruited a total of 250 Tan sheep and 174 healthy Hu sheep to detect 32 SNPs in GH, GHR, NPY, Leptin, H-FABP, MSTN, and CAST by using direct ...
DOI:
10.1007/s11250-019-02063-1
PubMed:
32026291
PubMed Central:
PMC7190689

16. Metabolomic approach in milk from calorie-restricted rats during lactation: a potential link to the programming of a healthy phenotype in offspring

Author:
Palou, Mariona; Torrens, Juana María; Castillo, Pedro; Sánchez, Juana; Palou, Andreu; Picó, Catalina
Source:
European journal of nutrition 2020 v.59 no.3 pp. 1191-1204
ISSN:
1436-6207
Subject:
leptin,   etc   ; adiponectin; adults; lactation; low calorie diet; metabolites; metabolomics; milk; milk composition; myo-inositol; obesity; phenotype; progeny; rats;     Show all 14 Subjects
Abstract:
... PURPOSE: Mild/moderate maternal calorie restriction during lactation in rats has been associated with a lower predisposition to obesity and a healthier metabolic profile in adult offspring. Here, we aimed to assess the impact of maternal calorie restriction during lactation on milk composition to identify potential candidate components that could be involved in the programming effects in offspring ...
DOI:
10.1007/s00394-019-01979-6

17. β2 adrenergic receptors and leptin interplay to decrease food intake in chicken

Author:
Zendehdel, M.; Khodadadi, M.; Vosoughi, A.; Mokhtarpouriani, K.; Baghbanzadeh, A.
Source:
British poultry science 2020 v.61 no.2 pp. 156-163
ISSN:
1466-1799
Subject:
leptin,   etc   ; adrenergic agonists; beta-2 adrenergic receptors; body weight; broiler chickens; dose response; feed intake; food intake; undereating; yohimbine;     Show all 10 Subjects
Abstract:
... 1. The present study was designed to examine the effects of intracerebroventricular (ICV) injection of different α and adrenergic receptor antagonists on leptin-induced hypophagia in broiler chickens. 2. The study consisted of six experiments. In all experiments, chickens were deprived of feed for 3 h prior to the ICV injections and thereafter were returned immediately to the individual cages and ...
DOI:
10.1080/00071668.2019.1704687

18. Endocrine and reproductive parameters in sick and healthy primiparous and multiparous dairy cows

Author:
Ruprechter, Gretel; Noro, Mirela; Meotti, Otavio; Batista, Chester; Adrien, M. de Lourdes; Barca, Joaquin; Meikle, Ana
Source:
Theriogenology 2020 v.141 pp. 173-179
ISSN:
0093-691X
Subject:
leptin,   etc   ; Holstein; adiponectin; calving; cohort studies; dairy cows; health status; insulin; insulin-like growth factor I; pregnancy; reproductive performance;     Show all 11 Subjects
Abstract:
... To investigate the association of health status and parity with hormone profiles during the transition period and reproductive parameters in Holstein dairy cows, a prospective observational cohort study was carried out including only healthy primiparous (PP, n = 116) and multiparous (MP, n = 172) cows at the beginning of the study. A subset of 120 healthy and sick cows was randomly selected for in ...
DOI:
10.1016/j.theriogenology.2019.09.026

19. Impact to short-term high intensity intermittent training on different storages of body fat, leptin and soluble leptin receptor levels in physically active non-obese men: A pilot investigation

Author:
Caldeira, Renan Santos; Panissa, Valéria Leme Gonçalves; Inoue, Daniela Sayuri; Campos, Eduardo Zapaterra; Monteiro, Paula Alves; Giglio, Bruna de Melo; Pimentel, Gustavo Duarte; Hofmann, Peter; Lira, Fábio Santos
Source:
Clinical nutrition ESPEN 2018 v.28 pp. 186-192
ISSN:
2405-4577
Subject:
leptin; leptin receptors,   etc   ; body fat; exercise; fasting; hunger; men;     Show all 7 Subjects
Abstract:
... Studies have postulated High Intensity Intermittent Training (HIIT) as a superior strategy to reduce body fat. The purpose of this study was to compare the effects HIIT and steady-state training (SST) on body composition, leptin, soluble leptin receptor (sOB-R) levels, and hunger perception in physically active non-obese men.Twenty men performed five weeks of HIIT (5 km – 1 min running at 100% spe ...
DOI:
10.1016/j.clnesp.2018.08.005

20. Immunolocalization of leptin and its receptor in the sheep ovary and in vitro effect of leptin on follicular development and oocyte maturation

Author:
Macedo, Taís Jobard S.; Santos, Jamile Maiara S.; Bezerra, Maria Éllida S.; Menezes, Vanúzia G.; Gouveia, Bruna B.; Barbosa, Lara Mariane R.; Lins, Thae Lane Barbosa G.; Monte, Alane Pains O.; Barberino, Ricássio S.; Batista, André M.; Barros, Vanessa Raquel P.; Wischral, Aurea; Queiroz, Mário Adriano A.; Araújo, Gherman Garcia L.; Matos, Maria Helena T.
Source:
Molecular and cellular endocrinology 2019 v.495 pp. 110506
ISSN:
0303-7207
Subject:
leptin,   etc   ; animal ovaries; follicular development; immunohistochemistry; mitochondria; oocytes; proteins; sheep;     Show all 8 Subjects
Abstract:
... The aims of the study were to characterize leptin and it is receptor (LEPR) proteins immunoexpression in ovine ovaries and to evaluate the effects of leptin on development of secondary follicles cultured in vitro. The ovaries were collected and fixed for immunohistochemical analysis. Additional pairs of ovaries were collected and secondary follicles were isolated and cultured, for 18 days, in α-ME ...
DOI:
10.1016/j.mce.2019.110506