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1. Trajectory of leptin and leptin receptor in vertebrates: Structure, function and their regulation

Author:
Amrita Bakshi; Rajeev Singh; Umesh Rai
Source:
Comparative biochemistry and physiology 2022 v.257 pp. 110652
ISSN:
1096-4959
Subject:
leptin; leptin receptors,   etc   ; catecholamines; food intake; glucocorticoids; physiology; refeeding;     Show all 7 Subjects
Abstract:
... The present review provides a comparative insight into structure, function and control of leptin system in fishes, herptiles, birds and mammals. In general, leptin acts as an anorexigenic hormone since its administration results in decrease of food intake in vertebrates. Nonetheless, functional paradox arises in fishes from contradictory observations on level of leptin during fasting and re-feedin ...
DOI:
10.1016/j.cbpb.2021.110652

2. Association of leptin and leptin receptor genes variants and pulmonary tuberculosis susceptibility, clinical manifestations in a Chinese population

Author:
Hong-Miao Li; Li-Jun Wang; Fei Tang; Hai-Feng Pan; Tian-Ping Zhang
Source:
Microbial pathogenesis 2022 v.165 pp. 105499
ISSN:
0882-4010
Subject:
leptin; leptin receptors,   etc   ; alleles; fever; genotyping; haplotypes; ligases; models; pathogenesis; tuberculosis;     Show all 10 Subjects
Abstract:
... The aim of our study was to investigate the association of leptin (LEP) gene (rs11761556, rs12706832, rs2167270), leptin receptor (LEPR) gene (rs1137100, rs1137101, rs1805096) variants and pulmonary tuberculosis (PTB) susceptibility, as well as their several clinical manifestations, in a Chinese population. This study included a cohort of 489 PTB patients and 489 healthy controls, and six SNPs wer ...
DOI:
10.1016/j.micpath.2022.105499

3. Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort

Author:
Yu-Hsuan Shih; Annelise J. Blomberg; Louise Helskov Jørgensen; Pál Weihe; Philippe Grandjean
Source:
Environmental research 2022 v.204 pp. 111905
ISSN:
0013-9351
Subject:
leptin; leptin receptors,   etc   ; Bayesian theory; adiponectin; blood serum; childhood; models; obesity; perfluorocarbons; regression analysis; research; resistin;     Show all 12 Subjects
Abstract:
... Per- and polyfluoroalkyl substances (PFAS) exposure has been linked to metabolic health outcomes such as obesity, and changes in adipokine hormones may be one of the underlying biological mechanisms. We prospectively evaluated the associations between prenatal and early childhood exposures to PFASs and adipokines in children. PFAS concentrations were measured in serum samples collected at birth, 1 ...
DOI:
10.1016/j.envres.2021.111905

4. Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study

Author:
Ruyi Cong; Xiaoyu Zhang; Zihong Song; Shanshan Chen; Guanhua Liu; Yizhi Liu; Xiuyu Pang; Fang Dong; Weijia Xing; Youxin Wang; Xizhu Xu
Source:
Nutrients 2022 v.14 no.5 pp. -
ISSN:
2072-6643
Subject:
leptin,   etc   ; adiponectin; gout; hyperuricemia; pleiotropy; uric acid;     Show all 6 Subjects
Abstract:
... Previous observational studies have highlighted associations between adipokines and hyperuricemia, as well as gout, but the causality and direction of these associations are not clear. Therefore, we attempted to assess whether there are causal effects of specific adipokines (such as adiponectin (ADP) and soluble leptin receptors (sOB-R)) on uric acid (UA) or gout in a two-sample Mendelian randomiz ...
DOI:
10.3390/nu14051091

5. Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN)

Author:
Seulbi Lee; Carrie Karvonen-Gutierrez; Bhramar Mukherjee; William H. Herman; Sung Kyun Park
Source:
Environmental pollution 2022 v.303 pp. 119164
ISSN:
0269-7491
Subject:
leptin; leptin receptors,   etc   ; 2,4-dichlorophenol; Bayesian theory; adiponectin; adipose tissue; benzophenones; bisphenol A; blood serum; burden of disease; cytokines; metabolic diseases; molecular weight; pollution; regression analysis; triclosan;     Show all 16 Subjects
Abstract:
... Adipokines, cytokines secreted by adipose tissue, may contribute to obesity-related metabolic disease. The role of environmental phenols and parabens in racial difference in metabolic disease burden has been suggested, but there is limited evidence. We examined the cross-sectional associations of urinary phenols and parabens with adipokines and effect modification by race. Urinary concentrations o ...
DOI:
10.1016/j.envpol.2022.119164

6. Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota

Author:
Francesco Suriano; Claudia Manca; Nicolas Flamand; Clara Depommier; Matthias Van Hul; Nathalie M. Delzenne; Cristoforo Silvestri; Patrice D. Cani; Vincenzo Di Marzo
Source:
Biochimica et biophysica acta 2022 v.1867 no.1 pp. 159056
ISSN:
1388-1981
Subject:
leptin; leptin receptors,   etc   ; adipose tissue; cannabinoids; gene expression; inflammation; insulin resistance; intestinal microorganisms; lipidomics; liver; liver function; metabolites; noninsulin-dependent diabetes mellitus; obesity; transcriptomics; transient receptor potential vanilloid channels;     Show all 16 Subjects
Abstract:
... Obesity and type 2 diabetes are two interrelated metabolic disorders characterized by insulin resistance and a mild chronic inflammatory state. We previously observed that leptin (ob/ob) and leptin receptor (db/db) knockout mice display a distinct inflammatory tone in the liver and adipose tissue. The present study aimed at investigating whether alterations in these tissues of the molecules belong ...
DOI:
10.1016/j.bbalip.2021.159056

7. Anti-obesity effects of Ishophloroglucin A from the brown seaweed Ishige okamurae (Yendo) via regulation of leptin signal in ob/ob mice

Author:
Nalae Kang; Seyeon Oh; Seo-Young Kim; Hyosang Ahn; Myeongjoo Son; Soo-Jin Heo; Kyunghee Byun; You-Jin Jeon
Source:
Algal research 2022 v.61 pp. 102533
ISSN:
2211-9264
Subject:
leptin; leptin receptors,   etc   ; Ishige okamurae; anti-obesity effects; appetite; cell lines; computer simulation; food intake; hypothalamus; immunocytochemistry; insulin; macroalgae; models; neurons; obesity; oral administration; phlorotannins; research; secondary metabolites; Korean Peninsula;     Show all 20 Subjects
Abstract:
... Brown seaweeds, which are macroalgae, are common foods and traditional medicines for Asians. Ishige okamurae (Yendo), found in Korea's shallow coastal areas, is one of the edible and medicinal brown seaweeds. Recent studies verified the pharmacological activities of the valuable properties from brown seaweeds such as ishophloroglucin A, a phlorotannin from I. okamurae. Recently, many studies have ...
DOI:
10.1016/j.algal.2021.102533

8. Cloning and expression of kiss genes and regulation of feeding in Siberian sturgeon (Acipenser baerii)

Author:
Shaoqi Xu; Mei Wang; Ya Li; Ni Tang; Xin Zhang; Hu Chen; Shupeng Zhang; Yanling Liu; Jun Wang; Defang Chen; Zhiqiong Li
Source:
Fish physiology and biochemistry 2022 v.48 no.2 pp. 419-436
ISSN:
0920-1742
Subject:
leptin,   etc   ; Acipenser baerii; appetite; fasting; fish; food intake; ghrelin; hypothalamus; intraperitoneal injection;     Show all 9 Subjects
Abstract:
... In 1996, kiss was reported to regulate feeding in mammals, but studies are limited in fish. Our study aimed to explore the possible role of kiss in the regulation of feeding in Siberian sturgeon (Acipenser baerii). kiss1 and kiss2 were cloned, and the expression patterns were analyzed in Siberian sturgeon. The complete coding regions of kiss1 and kiss2 genes were 393 and 471 bp. Both kiss1 and kis ...
DOI:
10.1007/s10695-022-01055-7

9. Seasonal and Nutritional Fluctuations in the mRNA Levels of the Short Form of the Leptin Receptor (LRa) in the Hypothalamus and Anterior Pituitary in Resistin-Treated Sheep

Author:
Weronika Biernat; Malgorzata Szczęsna; Katarzyna Kirsz; Dorota Anna Zieba
Source:
Animals 2021 v.11 no.8 pp. -
ISSN:
2076-2615
Subject:
leptin; leptin receptors,   etc   ; adiposity; anterior pituitary; diet; euthanasia; nutritional status; preoptic area; resistin;     Show all 9 Subjects
Abstract:
... The short form of the leptin receptor (LRa) plays a key role in the transport of leptin to the central nervous system (CNS). Here, the resistin (RSTN)-mediated expression of LRa in the preoptic area (POA), ventromedial and dorsomedial nuclei (VMH/DMH),arcuate nucleus (ARC) and the anterior pituitary gland (AP)was analyzed considering the photoperiodic (experiment 1) and nutritional status (experim ...
DOI:
10.3390/ani11082451

10. Gestational exposure to high fat diets and bisphenol A alters metabolic outcomes in dams and offspring, but produces hepatic steatosis only in dams

Author:
Elizabeth Marchlewicz; Carolyn McCabe; Zora Djuric; Mark Hoenerhoff; John Barks; Lu Tang; Peter X. Song; Karen Peterson; Vasantha Padmanabhan; Dana C. Dolinoy
Source:
Chemosphere 2022 v.286 pp. 131645
ISSN:
0045-6535
Subject:
leptin,   etc   ; Mediterranean diet; bisphenol A; blood serum; fatty liver; lactation; maternal exposure; phenotype; progeny; tissue weight;     Show all 10 Subjects
Abstract:
... The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. Perinatal development is a critical window for altered, lifelong health trajectory, and evidence supports the role of perinatal programming in chronic metabolic diseases. To examine the impact of diet and bisphenol A (BPA) on the developmental trajectory of NAFLD in offspring, we exposed dams from pre-gestation th ...
DOI:
10.1016/j.chemosphere.2021.131645

11. Metabolic memory determines gene expression in liver and adipose tissue of undernourished ewes

Author:
A. Fernández-Foren; A. Meikle; V. de Brun; A. Graña-Baumgartner; J.A. Abecia; C. Sosa
Source:
Livestock science 2022 v.260 pp. 104949
ISSN:
1871-1413
Subject:
leptin; leptin receptors,   etc   ; Rasa Aragonesa; adipose tissue; body condition; gene expression; insulin; liver; malnutrition; somatotropin receptors;     Show all 10 Subjects
Abstract:
... The aim of this work was to determine the effects of undernutrition on gene expression in liver and adipose tissue, and on the hepatic concentration of insulin like growth factor 1 (IGF1) and insulin, in pregnant ewes with different initial body condition score (iBCS). Thirty-six Rasa Aragonesa ewes were divided into 2 groups with different BCS: BCS > 2.75 (n = 19; high, H) and BCS < 2.25 (n = 17; ...
DOI:
10.1016/j.livsci.2022.104949

12. Leptin and Metabolic Programming

Author:
Catalina Picó; Mariona Palou
Source:
Nutrients 2021 v.14 no.1 pp. -
ISSN:
2072-6643
Subject:
leptin,   etc   ; breast milk; liquids; milk;     Show all 4 Subjects
Abstract:
... This Special Issue of Nutrients “Leptin and Metabolic Programming” includes one review article regarding the function of leptin throughout the entire life on cardiometabolic fates and four original articles related to the new function of leptin present in milk and liquid amniotic, its possible relation with other components of breast milk, and how environmental conditions may impact on leptin acti ...
DOI:
10.3390/nu14010114

13. Effect of disrupted episodic memory on food consumption: no impact of neuronal loss of endophilin A1 on food intake and energy balance

Author:
Jacques Togo; Yanrui Yang; Sumei Hu; Jia-Jia Liu; John R. Speakman
Source:
Journal of genetics and genomics 2022 v.49 no.4 pp. 329-337
ISSN:
1673-8527
Subject:
leptin,   etc   ; absorption; energy expenditure; food consumption; food intake; genetic factors; genomics; memory disorders; neurons; neuropeptides; spatial memory;     Show all 11 Subjects
Abstract:
... Food intake is generally assumed to reflect a regulatory tension between homeostatic and hedonic drivers. Information from individuals with memory dysfunction suggests that episodic memory may also play a significant role. We reasoned that if memory influences food intake, then disrupting a genetic factor that is important in episodic memory formation should affect food intake and energy balance. ...
DOI:
10.1016/j.jgg.2022.01.005

14. Metabolic hormones in human breast milk are preserved by high hydrostatic pressure processing but reduced by Holder pasteurization

Author:
Lucie Marousez; Léa Tran; Edwina Micours; Marie De Lamballerie; Frédéric Gottrand; Véronique Pierrat; Delphine Eberlé; Delphine Ley; Jean Lesage
Source:
Food chemistry 2022 v.377 pp. 131957
ISSN:
0308-8146
Subject:
leptin,   etc   ; adiponectin; breast milk; cortisol; food chemistry; glucagon-like peptide 1; high pressure treatment; insulin; milk; pasteurization;     Show all 10 Subjects
Abstract:
... In human milk banks (HMBs), donor milk (DM) is commonly sterilized by Holder pasteurization (HoP). High hydrostatic pressure (HHP) processing is an innovative, alternative method for DM sterilization. We evaluated the impact of HHP processing on the concentration of seven metabolic milk hormones. Eight samples of raw DM were aliquoted. One aliquot was sterilized by HoP (62 °C for 30 min), and anot ...
DOI:
10.1016/j.foodchem.2021.131957

15. Soy isoflavones plus soy protein effects on serum concentration of leptin in adults: A systematic review and meta-analysis of randomized clinical trials

Author:
Ali Gholami; Hamid Reza Baradaran; Mitra Hariri
Source:
Clinical nutrition ESPEN 2022 pp. -
ISSN:
2405-4577
Subject:
leptin,   etc   ; blood serum; clinical nutrition; confidence interval; isoflavones; meta-analysis; models; soy protein; standard deviation; systematic review;     Show all 10 Subjects
Abstract:
... Some studies conducted on soy isoflavones and soy protein reflected that leptin can be reduced by soy isoflavones or soy protein. The aim of present study is to assess the effect of soy isoflavones plus soy protein on serum concentration of leptin among adults. To find randomized clinical trails (RCTs) assessing the effect of soy isoflavones containing soy protein on serum concentration of leptin ...
DOI:
10.1016/j.clnesp.2022.03.015

16. Triacylglycerol rich in docosahexaenoic acid regulated appetite via the mediation of leptin and intestinal epithelial functions in high-fat, high-sugar diet-fed mice

Author:
Wanxiu Cao; Fang Liu; Robert W. Li; Ruili Yang; Yuming Wang; Changhu Xue; Qingjuan Tang
Source:
Journal of nutritional biochemistry 2022 v.99 pp. 108856
ISSN:
0955-2863
Subject:
leptin,   etc   ; appetite; cholecystokinin; docosahexaenoic acid; epithelium; food intake; high carbohydrate diet; hormone secretion; jejunum; overeating; transcriptomics; triacylglycerols;     Show all 12 Subjects
Abstract:
... High-fat, high-sugar diet (HFHS) induced leptin resistance and intestinal epithelial dysfunction is implicated in hyperphagia and metabolic disorders. Numerous studies have demonstrated the efficacy of dietary interventions for reducing appetite. This study aims to investigate whether triacylglycerol rich in DHA (DHA-TG) could regulate appetite in mice fed with a HFHS diet and the mechanism by whi ...
DOI:
10.1016/j.jnutbio.2021.108856

17. Effects of poor maternal nutrition during gestation on ewe and offspring plasma concentrations of leptin and ghrelin

Author:
L.M. Soranno; A.K. Jones; S.M. Pillai; M.L. Hoffman; S.A. Zinn; K.E. Govoni; S.A. Reed
Source:
Domestic animal endocrinology 2022 v.78 pp. 106682
ISSN:
0739-7240
Subject:
leptin,   etc   ; adiposity; adults; appetite; energy balance; ewes; ghrelin; homeostasis; maternal nutrition; metabolism; necropsy; nutritional intervention; parturition; pregnancy; progeny;     Show all 15 Subjects
Abstract:
... Poor maternal nutrition during gestation can negatively affect offspring growth, development, and health. Leptin and ghrelin, key hormones in energy homeostasis and appetite control, may mediate these changes. We hypothesized that restricted- and over-feeding during gestation would alter plasma concentrations of leptin and ghrelin in ewes and offspring. Pregnant ewes (n = 37) were fed 1 of 3 diets ...
DOI:
10.1016/j.domaniend.2021.106682

18. Effects of Leptin, Growth Hormone and Photoperiod on Pituitary SOCS-3 Expression in Sheep

Author:
Dorota Anna Zieba; Malgorzata Szczesna; Katarzyna Kirsz; Weronika Biernat
Source:
Animals 2022 v.12 no.3 pp. -
ISSN:
2076-2615
Subject:
leptin,   etc   ; cytokines; photoperiod; secretion; sheep; somatotropin;     Show all 6 Subjects
Abstract:
... This study examined how leptin affects growth hormone (GH) release and investigated the effects of leptin, GH, and day length on the suppressor of cytokine signaling-3 (SOCS-3) mRNA levels in the adenohypophyses of sheep. The study consisted of two experiments. The first experiment was conducted during long (LD) and short (SD) days. Within-season and replicate sheep were centrally infused with Rin ...
DOI:
10.3390/ani12030403

19. Are Peripheral Biomarkers Determinants of Eating Styles in Childhood and Adolescence Obesity? A Cross-Sectional Study

Author:
Lorena Desdentado; Jaime Navarrete; María Folgado-Alufre; Ana de Blas; Jéssica Navarro-Siurana; Francisco Ponce; Guadalupe Molinari; Andrea Jimeno-Martínez; Azahara I. Rupérez; Gloria Bueno-Lozano; Aida Cuenca-Royo; Emili Corbella; Zaida Agüera; Rosa M. Baños; Julio Álvarez-Pitti
Source:
Nutrients 2022 v.14 no.2 pp. -
ISSN:
2072-6643
Subject:
leptin,   etc   ; adiponectin; adolescence; biomarkers; childhood; childhood obesity; ghrelin; glucose; hematologic tests; insulin; insulin resistance; models; questionnaires; regression analysis; variance;     Show all 15 Subjects
Abstract:
... Disturbances in eating behaviors have been widely related to obesity. However, little is known about the role of obesity-related biomarkers in shaping habitual patterns of eating behaviors (i.e., eating styles) in childhood. The objective of the present study was to explore the relationships between several biomarkers crucially involved in obesity (ghrelin, insulin resistance, and leptin/adiponect ...
DOI:
10.3390/nu14020305

20. Immunohistochemical distributions of leptin, ghrelin and obestatin hormones in bull and ram abomasum

Author:
Zelal Karakoç; Uğur Topaloğlu; Bayram Bayram
Source:
Anatomia, histologia, embryologia 2022 v.51 no.3 pp. 411-418
ISSN:
0340-2096
Subject:
leptin,   etc   ; abomasum; blood; energy expenditure; epithelial cells; epithelium; feed intake; ghrelin; immune response; immunohistochemistry; peroxidase; rams; satiety; smooth muscle;     Show all 14 Subjects
Abstract:
... In most mammals, leptin plays central and peripheral roles in a wide range of metabolic activities including feed consumption and digestion, energy expenditure and the regulation of carbohydrate‐fat accumulation. Ghrelin is a strong appetite‐stimulating hormone, while obestatin has the opposite effect of ghrelin. The latter is released during feeding, causing a sense of satiety. This study aimed t ...
DOI:
10.1111/ahe.12801