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1. Biosynthesis of amidated pectins with ultra-high viscosity and low gelation restriction through ultra-low temperature enzymatic method

Author:
Chenmin Zheng; Yuping Zou; Yufan Huang; Bihua Shen; Peng Fei; Guoguang Zhang
Source:
Food hydrocolloids 2023 v.134 pp. 108037
ISSN:
0268-005X
Subject:
leucine,   etc   ; alanine; ammonia; biosynthesis; enzymatic treatment; ethanol; galacturonic acid; gelation; hardness; hydrocolloids; hydrogels; industry; medicine; pectins; temperature; thermal stability; valine; viscosity;     Show all 18 Subjects
Abstract:
... In traditional industry, amidated pectin was usually prepared by adding ammonia gas under the alkaline condition or ethanol system which degrades the galacturonic acid chain of pectin and weakens the advantage of amidated pectin in gel. In this study, amidated pectin with ultra-high viscosity and low gelation restriction were prepared by grafting with the neutral aliphatic amino acids through enzy ...
DOI:
10.1016/j.foodhyd.2022.108037

2. Integrated physiologic and proteomic analysis of Stropharia rugosoannulata mycelia in response to Cd stress

Author:
Qin Dong; Mingjie Chen; Yaru Zhang; Panpan Song; Huanling Yang; Yan Zhao; Changxia Yu; Lei Zha
Source:
Journal of hazardous materials 2023 v.441 pp. 129877
ISSN:
0304-3894
Subject:
leucine,   etc   ; Stropharia rugosoannulata; antioxidants; bioremediation; biosynthesis; energy; energy metabolism; gene expression regulation; growth retardation; homeostasis; human health; isoleucine; mycelium; pollution; proteome; proteomics; soil; toxicity; valine;     Show all 19 Subjects
Abstract:
... Soil Cd pollution seriously threatens environment and human health. Due to its ability to absorb and accumulate Cd in mycelia, Stropharia rugosoannulata could be a potential candidate for bioremediation of Cd-contaminated soils; however, the response mechanism of mycelia to Cd stress is still unclear. In this study, the physiologic and proteomic differences of S. rugosoannulata mycelia under 0.2 m ...
DOI:
10.1016/j.jhazmat.2022.129877

3. Amino acid degradation and related quality changes caused by common spoilage bacteria in chill-stored grass carp (Ctenopharyngodon idella)

Author:
Shuai Zhuang; Li Tian; Yueyue Liu; Luxin Wang; Hui Hong; Yongkang Luo
Source:
Food chemistry 2023 v.399 pp. 133989
ISSN:
0308-8146
Subject:
leucine,   etc   ; 3,4-dihydroxyphenylalanine oxidative deaminase; Aeromonas; Ctenopharyngodon idella; Pseudomonas putida; Shewanella putrefaciens; ammonia; arginine deiminase; deamination; food chemistry; freshwater fish; isoleucine; lyases; putrescine; quality control; spoilage;     Show all 16 Subjects
Abstract:
... To characterize the involvement of microorganisms in amino acid degradation and fish quality deterioration, three major grass carp spoilage bacteria were artificially inoculated in amino acid solutions (in-vitro) and grass carp flesh (in-situ). Results showed that Pseudomonas putida largely degraded free amino acids and produced 3.78 mM/100 g ammonia in grass carp flesh, relying on its high amino ...
DOI:
10.1016/j.foodchem.2022.133989

4. Comparative analysis of sugar, acid, and volatile compounds in CPPU-treated and honeybee-pollinated melon fruits during different developmental stages

Author:
Haiwen Chen; Jintao Cheng; Yuan Huang; Qiusheng Kong; Zhilong Bie
Source:
Food chemistry 2023 v.401 pp. 134072
ISSN:
0308-8146
Subject:
leucine,   etc   ; citric acid; ethyl acetate; food chemistry; fruit quality; fruits; gas chromatography-mass spectrometry; isoleucine; melons; metabolism; methionine; odor compounds; odors; phenylalanine; plant growth substances; sugars; valine;     Show all 17 Subjects
Abstract:
... Plant growth regulator N-(2-chloro-4-pyridyl)-N′-phenylurea (CPPU) is widely used in fruit production. However, the mechanism in which CPPU affects melon fruit quality, especially aroma compound, remains unclear. Here, gas chromatography–mass spectrometry was performed to detect the sugar, citric acid, and aroma content in CPPU-treated and pollinated melon fruit. Results showed that the applicatio ...
DOI:
10.1016/j.foodchem.2022.134072

5. An integrated proteomics and metabolomics investigation of feed efficiency in seawater reared Chinook salmon (Oncorhynchus tshawytscha)

Author:
Moha Esmaeili; Chris G. Carter; Richard Wilson; Seumas P. Walker; Matthew R. Miller; Andrew R. Bridle; Tim Young; Andrea C. Alfaro; Olivier Laroche; Jane E. Symonds
Source:
Aquaculture 2023 v.562 pp. 738845
ISSN:
0044-8486
Subject:
leucine,   etc   ; Oncorhynchus tshawytscha; amino acid metabolism; aquaculture; blood plasma; catabolism; data collection; feed conversion; fish; genes; glucose; glutathione; isoleucine; liver; metabolites; metabolomics; multiomics; muscles; phenotype; phenylalanine; protein degradation; protein synthesis; proteolysis; proteomics; pyruvic acid; seawater; tryptophan; tyrosine; valine;     Show all 29 Subjects
Abstract:
... Feed efficiency (FE) is a critical phenotype for aquaculture sustainability, yet it is poorly understood at the molecular level. In this study, the molecular basis of FE was investigated using a multi-omics approach to integrate proteome-level data and metabolites associated with differences in feed efficiency. To achieve this, Chinook salmon (Oncorhynchus tshawytscha) were reared in seawater and ...
DOI:
10.1016/j.aquaculture.2022.738845

6. Amino acid regulated co-assembly for formation of one-dimensional ordered monocrystal by hydrogen bonding interactions

Author:
Qianqian Dong; Meiyue Wang; Chunjing Yu; Qi Li; Shuo Bai; Jian Yin; Qingjun You
Source:
Colloids and surfaces 2022 v.636 pp. 128169
ISSN:
0927-7757
Subject:
leucine,   etc   ; crystallization; hydrogen;     Show all 3 Subjects
Abstract:
... The interaction between amino acid molecules, especially crystallization, has always been the focus of researches. In this article, we use C-terminally aminated leucine (L-NH₂) to regulate and co-assemble with amino acid model molecules to obtain a one-dimensional ordered monocrystal structure. We propose a possible electrostatic attraction-enhanced hydrogen bonding interaction between amino acids ...
DOI:
10.1016/j.colsurfa.2021.128169

7. Self-Assembly of Functional Protein Nanosheets from Thermoresponsive Bolaamphiphiles

Author:
Dylan R. Dautel; Julie A. Champion
Source:
Biomacromolecules 2022 v.23 no.9 pp. 3612-3620
ISSN:
1526-4602
Subject:
leucine; leucine zipper,   etc   ; biocatalysis; fluorescence; graphene; hydrophilicity; hydrophobicity; liquid-air interface; malate synthase; nanosheets; peptides;     Show all 11 Subjects
Abstract:
... Nanosheets are two-dimensional materials, less than 100 nm thick, that can be used for separations, biosensing, and biocatalysis. Nanosheets can be made from inorganic and organic materials such as graphene, polymers, and proteins. Here, we report the self-assembly of nanosheets under aqueous conditions from functional proteins. The nanosheets are synthesized from two fusion proteins held together ...
DOI:
10.1021/acs.biomac.2c00525

8. Enzymatic processing and MHC loading 2Peptide editing mediated by TAPBPR

Author:
F. Tudor Ilca; Andreas Neerincx; Clemens Hermann; Ana Marcu; Stefan Stevanović; Janet E. Deane; Louise H. Boyle
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
leucine,   etc   ; dissociation; humans; immunology; mice; peptides;     Show all 6 Subjects
Abstract:
... Although tapasin and TAPBPR are known to perform peptide editing on MHC class I molecules, the precise molecular mechanism(s) involved in this process remain largely enigmatic. The recently reported crystal structures of human TAPBPR in complex with mouse MHC class I demonstrated that TAPBPR facilitates peptide exchange by widening the peptide binding groove of MHC class I at the α2–1 region. Howe ...
DOI:
10.1016/j.molimm.2022.05.016

9. Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity-Making Mutations

Author:
Juan Luis Pacheco-Garcia; Dmitry S. Loginov; Ernesto Anoz-Carbonell; Pavla Vankova; Rogelio Palomino-Morales; Eduardo Salido; Petr Man; Milagros Medina; Athi N. Naganathan; Angel L. Pey
Source:
Antioxidants 2022 v.11 no.6 pp. -
ISSN:
2076-3921
Subject:
leucine,   etc   ; active sites; mutation; proteins; solubility;     Show all 5 Subjects
Abstract:
... Allosterism is a common phenomenon in protein biochemistry that allows rapid regulation of protein stability; dynamics and function. However, the mechanisms by which allosterism occurs (by mutations or post-translational modifications (PTMs)) may be complex, particularly due to long-range propagation of the perturbation across protein structures. In this work, we have investigated allosteric commu ...
DOI:
10.3390/antiox11061110

10. Numerous variants of leucine rich repeats in proteins from nucleo-cytoplasmic large DNA viruses

Author:
Norio Matsushima; Robert H. Kretsinger
Source:
Gene 2022 v.817 pp. 146156
ISSN:
0378-1119
Subject:
leucine,   etc   ; DNA; cysteine; genes; hydrophobicity; metagenomics;     Show all 6 Subjects
Abstract:
... Leucine rich repeats (LRRs) occurring in tandem are 20–29 amino acids long. Eleven LRR types have been recognized. Sequence features of LRRs from viruses were investigated using over 600 LRR proteins from 89 species. Directly before, metagenome data of nucleo-cytoplasmic large dsDNA viruses (NCLDVs) have been published; the 2,074 NCLDVs encode 199,021 proteins. From the NCLDVs 547 LRR proteins wer ...
DOI:
10.1016/j.gene.2021.146156

11. Reconsidering the in vivo functions of Clostridial Stickland amino acid fermentations

Author:
Aidan Pavao; Madeline Graham; Mario L. Arrieta-Ortiz; Selva Rupa Christinal Immanuel; Nitin S. Baliga; Lynn Bry
Source:
Anaerobe 2022 v.76 pp. 102600
ISSN:
1075-9964
Subject:
leucine,   etc   ; Clostridium difficile; genes; ornithine; oxidoreductases; pathogens; proline;     Show all 7 Subjects
Abstract:
... Stickland amino acid fermentations occur primarily among species of Clostridia. An ancient form of metabolism, Stickland fermentations use amino acids as electron acceptors in the absence of stronger oxidizing agents and provide metabolic capabilities to support growth when other fermentable substrates, such as carbohydrates, are lacking. The reactions were originally described as paired fermentat ...
DOI:
10.1016/j.anaerobe.2022.102600

12. Influence of amino acid residue on chromatographic behaviour of μ-opioid receptor agonist tetrapeptide analogue on crown ether based chiral stationary phase

Author:
T. Upmanis; H. Kažoka
Source:
Journal of chromatography 2022 v.1673 pp. 463059
ISSN:
0021-9673
Subject:
leucine,   etc   ; agonists; chromatography; cysteine; enantiomers; glutamic acid; histidine; tryptophan;     Show all 8 Subjects
Abstract:
... The influence of amino acid residue on μ-opioid receptor agonist tetrapeptide Tyr-Arg-Phe-Lys-NH₂ analogue chromatographic behaviour on crown ether based chiral stationary phases has been investigated. S- and R-(3,3′-diphenyl-1,1′-binaphthyl)-20-crown-6 chiral selectors in commercially available CROWNPAK CR-I (+) and (-) columns are both each other enantiomers, thus, under the same LC conditions, ...
DOI:
10.1016/j.chroma.2022.463059

13. Protein synthesis as a modifiable target for autism‐related dendritic spine pathophysiologies

Author:
Ming‐Hsuan Lu; Yi‐Ping Hsueh
Source:
FEBS journal 2022 v.289 no.8 pp. 2282-2300
ISSN:
1742-464X
Subject:
leucine,   etc   ; autism; brain; dendrites; mutants; pathophysiology; protein synthesis; rapamycin;     Show all 8 Subjects
Abstract:
... Autism spectrum disorder (ASD) is increasingly recognized as a condition of altered brain connectivity. As synapses are fundamental subcellular structures for neuronal connectivity, synaptic pathophysiology has become one of central themes in autism research. Reports disagree upon whether the density of dendritic spines, namely excitatory synapses, is increased or decreased in ASD and whether the ...
DOI:
10.1111/febs.15733

14. Electrolyte Effects on the Amino Acid Solubility in Water: Solubilities of Glycine, l-Leucine, l-Phenylalanine, and l-Aspartic Acid in Salt Solutions of (Na⁺, K⁺, NH₄⁺)/(Cl–, NO₃–)

Author:
Mehriban Aliyeva; Paula Brandão; José R. B. Gomes; João A. P. Coutinho; Olga Ferreira; Simão P. Pinho
Source:
Industrial & engineering chemistry process design and development 2022 v.61 no.16 pp. 5620-5631
ISSN:
1520-5045
Subject:
leucine,   etc   ; aspartic acid; gravimetry; nitrates; phenylalanine; process design; solubility;     Show all 7 Subjects
Abstract:
... The solubilities of glycine, l-leucine, l-phenylalanine, and l-aspartic acid in aqueous solutions of the salts composed by combining Na⁺, K⁺, and NH₄⁺ cations and Cl– and NO₃– anions were measured up to 2.0 salt molality at 298.2 K by the analytical gravimetric method. Using these data along with a review of literature information, encompassing all amino acids for which solubility is available in ...
DOI:
10.1021/acs.iecr.1c04562

15. Genetic, metabolic and immunological features of cancers with NRF2 addiction

Author:
Hiroshi Kitamura; Haruna Takeda; Hozumi Motohashi
Source:
FEBS letters 2022 v.596 no.16 pp. 1981-1993
ISSN:
0014-5793
Subject:
basic-leucine zipper transcription factors,   etc   ; Lewis acids; carcinogenesis; humans; therapeutics;     Show all 5 Subjects
Abstract:
... Nuclear factor erythroid‐derived 2‐like 2 (NRF2) is a master transcription factor that coordinately regulates the expression of many cytoprotective genes and plays a central role in defense mechanisms against oxidative and electrophilic insults. Although increased NRF2 activity is principally beneficial for our health, NRF2 activation in cancer cells is detrimental. Many human cancers exhibit pers ...
DOI:
10.1002/1873-3468.14458

16. Sustainable preparation of spherical amphoteric organics:Isoelectric point-spherical agglomeration technology

Author:
Shilin Guo; Shanshan Feng; Changyou Yu; Yanbo Liu; Mingyang Chen; Junbo Gong
Source:
Powder technology 2022 v.407 pp. 117645
ISSN:
0032-5910
Subject:
leucine,   etc   ; adhesion; agitation; crystallization; isoelectric point; liquids; separation; solutes; technology; tryptophan;     Show all 10 Subjects
Abstract:
... This work developed a sustainable and highly-efficient isoelectric point-spherical agglomeration (IPSA) technology for preparing spherical particles of amphoteric organics. The IPSA technology couples isoelectric point crystallization and spherical agglomeration (SA), eliminating the most polluting part in SA technology, i.e. the use of solvents and anti-solvents, and also achieving multiple recyc ...
DOI:
10.1016/j.powtec.2022.117645

17. 14-3-3β is essential for milk composition stimulated by Leu/IGF-1 via IGF1R signaling pathway in BMECs

Author:
Hui Cao; Guan Huang; Haixin Fu; Na Zhang
Source:
In vitro cellular & developmental biology 2022 v.58 no.5 pp. 384-395
ISSN:
1071-2690
Subject:
leucine,   etc   ; cattle; cell proliferation; epithelium; genes; milk; milk fat; milk synthesis;     Show all 8 Subjects
Abstract:
... The cell proliferation of bovine mammary epithelial cells (BMECs) and consequent milk synthesis are regulated by multiple factors. The purpose of this study was to examine the effect of 14-3-3β on cellular proliferation and milk fat/β-casein synthesis in BMECs and reveal its underlying mechanisms. In this study, we employed gene function analysis to explore the regulatory effect and molecular mech ...
DOI:
10.1007/s11626-022-00682-x

18. Characterization of the variable lymphocyte receptor B genes of a freshwater nonparasitic lamprey species, Lampetra hubbsi

Author:
Kyle L. Rekedal; Khan MA. Hassan; Chris T. Amemiya
Source:
Developmental and comparative immunology 2022 v.126 pp. 104241
ISSN:
0145-305X
Subject:
leucine,   etc   ; Lampetra; Petromyzon marinus; adaptive immunity; freshwater; immunoglobulins; organogenesis; rivers; California;     Show all 9 Subjects
Abstract:
... Agnathans possess a convergent adaptive immune system in comparison to that of jawed vertebrates. In lieu of immunoglobulins, agnathans deploy variable lymphocyte receptors (VLRs), single chain protein effector molecules consisting of leucine rich repeat modules. Foundational work for this discovery utilized the parasitic sea lamprey, Petromyzon marinus. However, for several reasons, it is desirab ...
DOI:
10.1016/j.dci.2021.104241

19. Failure of excess leucine to impact live performance and carcass traits in male and female Cobb MV × 500 broilers during a 15- to 32-day grower period

Author:
C.W. Maynard; G.J. Mullenix; C.J. Maynard; J.T. Lee; S.K. Rao; L.D. Butler; J.Z. Hiltz; S.K. Orlowski; M.T. Kidd
Source:
Journal of applied poultry research 2022 v.31 no.2 pp. 100242
ISSN:
1056-6171
Subject:
leucine,   etc   ; antagonism; feed intake; females; industry; isoleucine; lysine; males; research; valine;     Show all 10 Subjects
Abstract:
... Modern broiler diets may contain excess levels of leucine due to the increased level of this amino acid in cereal grains. Excessive levels of leucine have previously been shown to negatively influence broiler performance due to branched-chain amino acid antagonism. Therefore, 2 leucine titrations were conducted in male and female Cobb 500 broilers. Low and high leucine diets were formulated to con ...
DOI:
10.1016/j.japr.2022.100242

20. Improvement of bone marrow mononuclear cells cryopreservation methods to increase the efficiency of dendritic cell production

Author:
H. Kysielova; K. Yampolska; T. Dubrava; O. Lutsenko; M. Bondarovych; N. Babenko; Yu Gaevska; M. Ostankov; A. Goltsev
Source:
Cryobiology 2022 v.106 pp. 122-130
ISSN:
0011-2240
Subject:
leucine zipper,   etc   ; bone marrow; coculture; cryobiology; cryopreservation; dendritic cells; heat stress;     Show all 7 Subjects
Abstract:
... Cryopreservation is now considered an integral part of the biotechnological process, exploiting different types of cells and tissues in clinical practice. Among them, dendritic cells (DCs) deserve special attention, notably the immature tolerogenic cells (tolDCs), which provide natural tolerance in humans and animals. High cryolability of tolDCs has necessitated the search for the methods that wou ...
DOI:
10.1016/j.cryobiol.2022.02.004