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1. Oxidation of Licorice-Root Triterpene-Acid Derivatives by m-Chloroperbenzoic Acid

Author:
Mikhailova, L. R.; Budaev, A. S.; Spirikhin, L. V.; Baltina, L. A.
Source:
Chemistry of natural compounds 2019 v.55 no.1 pp. 88-91
ISSN:
0009-3130
Subject:
licorice,   etc   ; acids; chemical structure; esters; nuclear magnetic resonance spectroscopy; oxidation;     Show all 6 Subjects
Abstract:
... Methyl esters of 3β-O-acetoxy-18βH-olean-12-en-30-oic, 3β-hydroxy-9(11),12(13)-dien-30-oic, and 3β-O-acetoxy-18βH-olean-12-en-30-oic acids were oxidized by meta-chloroperbenzoic acid (m-CPBA) to produce methyl esters of 3β-O-acetoxy-12α,13α-epoxy-18β-oleanan-30-oic and 3β-O-acetoxy-18β-oleanan-12-on-30-oic acids in addition to 3β-hydroxy-12-oxo-18βH-olean-9(11)-en-30-oic and 3β-O-acetoxy-18β-olean ...
DOI:
10.1007/s10600-019-02619-5

2. Licorice flavonoids nanoparticles prepared by liquid antisolvent re-crystallization exhibit higher oral bioavailability and antioxidant activity in rat

Author:
Wang, Zijian; Zhao, Xiuhua; Zu, Yuangang; Wu, Weiwei; Li, Yuanyuan; Guo, Zijing; Wang, Li; Wang, Lingling
Source:
Journal of functional foods 2019 v.57 pp. 190-201
ISSN:
1756-4646
Subject:
licorice,   etc   ; antioxidant activity; bioavailability; biosafety; flavonoids; gastric juice; health services; liquids; nanoparticles; rats; solubility;     Show all 11 Subjects
Abstract:
... The aim of the experiment was to prepare licorice flavonoids nanoparticles (LFNs) by a liquid antisolvent re-crystallization (LAR) method to improve its oral bioavailability. The experimental data suggested that the saturation solubility of LFNs was 25 times of raw licorice flavonoids (LFs), and at 720 min, the dissolution rates of LFNs in artificial intestinal juice and artificial gastric juice w ...
DOI:
10.1016/j.jff.2019.04.010

3. Establishing the chromatographic fingerprint of traditional Chinese medicine standard decoction based on quality by design approach: A case study of Licorice

Author:
Zhang, Hui; Wang, Jianan; Chen, Yan; Shen, Xiaowei; Jiang, Huijie; Gong, Xingchu; Yan, Jizhong
Source:
Journal of separation science 2019 v.42 no.6 pp. 1144-1154
ISSN:
1615-9306
Subject:
licorice,   etc   ; Oriental traditional medicine; acetonitrile; case studies; formic acid; high performance liquid chromatography; temperature; wavelengths;     Show all 8 Subjects
Abstract:
... A novel analytical quality by design approach for developing a chromatographic fingerprint was established for analyzing complex traditional Chinese medicine, using a licorice standard decoction as an example. Considering the characteristics of integrity and ambiguity, the resolution of eight common peaks, total peak number, capacity factor distributions, and peak purity were selected as potential ...
DOI:
10.1002/jssc.201800989

4. Effect of seedling grade standard on improving the quality of licorice (Glycyrrhiza uralensis F.): changes in the seven bioactive components and root biomass during two-year growth

Author:
Hou, Jia; Guo, Hongru; Du, Tao; Shao, Shijun; Zhang, Yanhong
Source:
Food science and biotechnology 2018 v.27 no.4 pp. 939-945
ISSN:
1226-7708
Subject:
licorice,   etc   ; Glycyrrhiza uralensis; bioactive compounds; biomass; glycyrrhizin; herbal medicines; seedlings;     Show all 7 Subjects
Abstract:
... Licorice cultivated is one of the most popular herbal medicines, while its quality is unstable. The aim of present study is to investigate the effect of licorice seedling grade standard on improving its quality. One-year-old Glycyrrhiza uralensis seedlings were classified into three grades 1, 2, and 3 by weight per plant. The major root biomass indexes (root fresh weight, root dry weight and tapro ...
DOI:
10.1007/s10068-018-0333-1

5. Liquiritinapioside – A mineralocorticoid-like substance from liquorice

Author:
Fan, Simiao; Gu, Kun; Wu, Yuanyuan; Luo, Houmin; Wang, Yuming; Zhang, Tianpu; Wang, Xing; Zhang, Yanjun; Li, Yubo
Source:
Food chemistry 2019 v.289 pp. 419-425
ISSN:
0308-8146
Subject:
licorice,   etc   ; Western blotting; agonists; binding capacity; collagen; fibrosis; mineralocorticoid receptors; mitogen-activated protein kinase; signal transduction; staining; surface plasmon resonance;     Show all 11 Subjects
Abstract:
... Surface plasmon resonance (SPR) analysis of the main components of liquorice was performed and a novel strong mineralocorticoid receptor (MR) agonist, namely liquiritinapioside (LA), whose the binding constant was 1.093 × 10−5 M, was reported. As a supplement, LA has been further demonstrated to have a strong MR binding capacity through competitive binding experiments (the enrichment factor of LA ...
DOI:
10.1016/j.foodchem.2019.03.056

6. Effects of heating on the total phenolic content, antioxidant activities and main functional components of simulated Chinese herb candy during boiling process

Author:
Yin, Qianqian; Mu, Haibo; Zeng, Maomao; Gao, Daming; Qin, Fang; Chen, Jie; He, Zhiyong
Source:
Journal of food measurement & characterization 2019 v.13 no.1 pp. 476-486
ISSN:
2193-4126
Subject:
licorice,   etc   ; 2,2-diphenyl-1-picrylhydrazyl; Chrysanthemum; Taraxacum; antioxidant activity; boiling; candy; chlorogenic acid; heat; leaves; mulberries; naringin; rutin; tangerines; temperature;     Show all 15 Subjects
Abstract:
... The effects of heating (100–140 °C/10–180 min) on functional component contents, total phenolic content (TPC) and antioxidant activities of six simulated Chinese herb candies containing honeysuckle, chrysanthemum, dandelion, liquorice, mulberry leaf and tangerine, respectively were studied, which revealed that TPC and antioxidant activity of candies significantly increased (p < 0.05) with increasi ...
DOI:
10.1007/s11694-018-9961-7

7. Development of chloroplast microsatellite markers for identification of Glycyrrhiza species

Author:
Lee, Kyung Jun; Raveendar, Sebastin; Choi, Ji Seon; Gil, Jinsu; Lee, Jeong Hoon; So, Yoon-Sup; Chung, Jong-Wook
Source:
Plant genetic resources 2019 v.17 no.1 pp. 95-98
ISSN:
1479-263X
Subject:
licorice,   etc   ; Glycyrrhiza glabra; Glycyrrhiza lepidota; alleles; chloroplast genome; chloroplasts; genetic markers; genetic variation; loci; medicinal plants; microsatellite repeats; traditional medicine;     Show all 12 Subjects
Abstract:
... Licorice (Glycyrrhiza glabra) is an important medicinal herb and has long been used in traditional medicine for the treatment of several diseases worldwide. Understanding the genetic diversity within Glycyrrhiza species is important for the efficient conservation of these medicinal herbs. In this study, we have developed 20 polymorphic chloroplast microsatellite (cpSSR) markers using the chloropla ...
DOI:
10.1017/S1479262118000308

8. An efficient DNA barcoding based method for the authentication and adulteration detection of the powdered natural spices

Author:
Zhang, Mengting; Shi, Yuhua; Sun, Wei; Wu, Lan; Xiong, Chao; Zhu, Zhihui; Zhao, Hongfei; Zhang, Bolin; Wang, Caixia; Liu, Xia
Source:
Food control 2019 v.106 pp. 106745
ISSN:
0956-7135
Subject:
licorice,   etc   ; DNA; DNA barcoding; adulterants; adulterated products; color; corn; fennel; flavorings; food additives; internal transcribed spacers; preservatives; public health; quality control; rice; spices; traditional medicine; wheat flour;     Show all 18 Subjects
Abstract:
... Natural spices are widely used as food additives, coloring and flavoring agents, preservatives, and traditional medicines. However, the authentication and adulteration detection of spices, particularly the powdered ones, is a significant challenge and public health concern in the growing spice industry. To address this issue, a DNA barcoding-based identification method was developed in this study. ...
DOI:
10.1016/j.foodcont.2019.106745

9. Co-expression of anti-miR319g and miRStv_11 lead to enhanced steviol glycosides content in Stevia rebaudiana

Author:
Saifi, Monica; Yogindran, Sneha; Nasrullah, Nazima; Nissar, Umara; Gul, Irum; Abdin, M. Z.
Source:
BMC plant biology 2019 v.19 no.1 pp. 274
ISSN:
1471-2229
Subject:
licorice,   etc   ; Stevia rebaudiana; biochemical pathways; diabetes; gene expression regulation; gene overexpression; gene regulatory networks; genes; glycosides; leaf extracts; microRNA; steviol; stevioside; sweeteners; taste sensitivity;     Show all 15 Subjects
Abstract:
... BACKGROUND: miRNAs are major regulators of gene expression and have proven their role in understanding the genetic regulation of biosynthetic pathways. Stevioside and rebaudioside-A, the two most abundant and sweetest compounds found in leaf extract of Stevia rebaudiana, have been used for many years in treatment of diabetes. It has been found that the crude extract is more potent than the purifie ...
DOI:
10.1186/s12870-019-1871-2

10. Antioxidant and antimicrobial assessment of licorice supercritical extracts

Author:
Quintana, Somaris E.; Cueva, Carolina; Villanueva-Bermejo, David; Moreno-Arribas, M. Victoria; Fornari, Tiziana; García-Risco, Mónica R.
Source:
Industrial crops and products 2019 v.139 pp. 111496
ISSN:
0926-6690
Subject:
licorice,   etc   ; Glycyrrhiza glabra; antimicrobial properties; antioxidant activity; antioxidants; bioactive compounds; carbon dioxide; ethanol; fractionation; glycyrrhizin; herbal medicines; high performance liquid chromatography; phenolic compounds; roots;     Show all 14 Subjects
Abstract:
... Licorice (Glycyrrhiza glabra L.) is a plant used widely in herbal medicines due to their several biological potentials. The supercritical extraction of licorice roots was investigated to assess the antioxidant and antimicrobial activity of the extracts. Extraction conditions were pressures from 15 to 40 MPa, 313.15 and 333.15 K, and ethanol cosolvent in the range of 0 to 20% mass. In the case of h ...
DOI:
10.1016/j.indcrop.2019.111496

11. Derivatization, molecular docking and in vitro acetylcholinesterase inhibitory activity of glycyrrhizin as a selective anti-Alzheimer agent

Author:
Abdel Bar, Fatma M.; Elimam, Diaaeldin M.; Mira, Amira S.; El-Senduny, Fardous F.; Badria, Farid A.
Source:
Natural product research 2019 v.33 no.18 pp. 2591-2599
ISSN:
1478-6427
Subject:
licorice,   etc   ; Alzheimer disease; acetylcholine; acetylcholinesterase; active ingredients; computer simulation; derivatization; enzyme inhibition; enzyme inhibitors; glycyrrhetinic acid; glycyrrhizin; inhibitory concentration 50; medicinal properties; screening;     Show all 14 Subjects
Abstract:
... Acetylcholinesterase inhibitors (AChE-Is) increase both level and duration of action of acetylcholine (ACh); thus, alleviate symptoms of Alzheimer’s disease (AD). Glycyrrhizin, is the main active compound in liquorice root. Its aglycone, glycyrrhetinic acid, has shown several beneficial pharmacological activities. This study reports the synthesis and screening of a series of glycyrrhetinic acid an ...
DOI:
10.1080/14786419.2018.1462177

12. Utilization trends in traditional Chinese medicine for acute myocardial infarction

Author:
Lu, Chung-Yen; Lu, Pei-Chin; Chen, Pei-Chun
Source:
Journal of ethnopharmacology 2019 v.241 pp. 112010
ISSN:
0378-8741
Subject:
licorice,   etc   ; Oriental traditional medicine; Salvia miltiorrhiza; blood; cross-sectional studies; death; health insurance; hospitals; hyperlipidemia; men; myocardial infarction; patients; therapeutics; Taiwan;     Show all 14 Subjects
Abstract:
... Among heart diseases, acute myocardial infarction (AMI) is the most serious and life-threatening emergency. In Taiwan, heart disease has consistently ranked second among the top 10 leading causes of death since 2007, second only to malignant tumors; however, population-based studies on the use of traditional Chinese medicine (TCM) in AMI cases are limited.Aim of the study: This study investigated ...
DOI:
10.1016/j.jep.2019.112010

13. Quantitative fingerprint and quality control analysis of Compound Liquorice Tablet combined with antioxidant activities and chemometrics methods

Author:
Zhang, Yujing; Yang, Fangliang; Zhang, Jing; Sun, Guoxiang; Wang, Chao; Guo, Yong; Wen, Ran; Sun, Wanyang
Source:
Phytomedicine 2019 v.59 pp. 152790
ISSN:
0944-7113
Subject:
licorice,   etc   ; active ingredients; alkaloids; antioxidant activity; antioxidants; bioactive compounds; chemometrics; cluster analysis; flavonoids; herbal medicines; high performance liquid chromatography; least squares; medicinal properties; models; monitoring; quality control; saponins;     Show all 17 Subjects
Abstract:
... Herbal medicine (HM), as a complex system, is difficult to investigate their quality consistency effectively by chromatographic fingerprinting obtained in a single detection method. Moreover, active compound discovery affords no information about pharmacological activity until late in the discovery process, and the interaction between HMs in vitro is not yet clear, which requires sufficient practi ...
DOI:
10.1016/j.phymed.2018.12.013

14. Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin

Author:
Razzak, Md. Abdur; Lee, Ji Eun; Choi, Shin Sik
Source:
Food hydrocolloids 2019 v.91 pp. 290-300
ISSN:
0268-005X
Subject:
licorice,   etc   ; bioactive properties; blood plasma; computer simulation; fluorescence; fluorescence emission spectroscopy; food industry; foods; human serum albumin; hydrocolloids; hydrodynamics; hydrophobic bonding; ligands; pharmaceutical industry; solubility; tryptophan; zeta potential;     Show all 17 Subjects
Abstract:
... Glabridin (GB), a prenylated isoflavonoid in licorice root has been used as foods and medicines with beneficial biological activities. Human serum albumin (HSA) is the most abundant blood plasma protein binding and transporting ligands such as GB. The present study investigated the interaction between GB and HSA using multi-spectroscopic and molecular docking techniques. Fluorescence spectroscopy ...
DOI:
10.1016/j.foodhyd.2019.01.031

15. Identification of key transporters mediating uptake of aconitum alkaloids into the liver and kidneys and the potential mechanism of detoxification by active ingredients of liquorice

Author:
He, Yufei; Wang, Ze; Wu, Weidang; Xie, Ying; Wei, Zihong; Yi, Xiulin; Zeng, Yong; Li, Yazhuo; Liu, Changxiao
Source:
RSC advances 2019 v.9 no.28 pp. 16136-16146
ISSN:
2046-2069
Subject:
licorice,   etc   ; Aconitum; aconitine; active ingredients; analgesia; hepatocytes; in vitro studies; in vivo studies; inhibitory concentration 50; kidneys; liver; rheumatoid arthritis; toxicity; transporters;     Show all 14 Subjects
Abstract:
... Aconite as a commonly used herb has been extensively applied in the treatment of rheumatoid arthritis, as pain relief, as well as for its cardiotonic actions. Aconitum alkaloids have been shown to be the most potent ingredients in aconite, in terms of efficacy against disease, but they are also highly toxic. Apart from neurological and cardiovascular toxicity exposed, the damage to hepatocytes and ...
DOI:
10.1039/c9ra00393b

16. Enrichment of total flavones and licochalcone A from licorice residues and its hypoglycemic activity

Author:
Luo, Zhonghua; Guo, Zhenghong; Xiao, Ting; Liu, Hairong; Su, Guangyue; Zhao, Yuqing
Source:
Journal of chromatography 2019 v.1114-1115 pp. 134-145
ISSN:
1570-0232
Subject:
licorice,   etc   ; bioactive compounds; blood glucose; chromatography; cost effectiveness; crystallization; ethanol; flavones; glycemic effect; high fat diet; mice; physical properties; polyamides; porous media; processing technology; resins; waste management;     Show all 17 Subjects
Abstract:
... Industrial processing of glycyrrhizic leads to a lot of residues which are usually threw away randomly or used as feed. Therefore, the purpose of this study was to study licorice residues as a source of bioactive compounds with potentially applications. In this study, the enrichment and purification of total flavones from the licorice residues was achieved by using macroporous resins. The performa ...
DOI:
10.1016/j.jchromb.2019.01.026

17. Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4

Author:
Yokoyama, Takeshi; Matsumoto, Kazunori; Ostermann, Andreas; Schrader, Tobias E.; Nabeshima, Yuko; Mizuguchi, Mineyuki
Source:
TheFEBS journal 2019 v.286 no.9 pp. 1656-1667
ISSN:
1742-464X
Subject:
licorice,   etc   ; X-ray diffraction; antineoplastic agents; chalcone; crystallography; enthalpy; gene expression regulation; histones; hydrogen bonding; lysine; neutrons; oncogenes; screening; transcriptional elongation factors;     Show all 14 Subjects
Abstract:
... Bromodomain‐containing protein 4 (BRD4) recognizes the acetylated lysine of histone H4 via its bromodomains, leading to the recruitment of positive transcription elongation factor b. Small molecules that inhibit BRD4 have potential as anticancer agents by leading to the downregulation of specific oncogenes. Using X‐ray crystallographic screening, we identified the BRD4 inhibitory activity of isoli ...
DOI:
10.1111/febs.14736

18. Structures and In Vitro Antihepatic Fibrosis Activities of Prenylated Dihydrostilbenes and Flavonoids from Glycyrrhiza uralensis Leaves

Author:
Fan, Yu‐Hong; Ye, Rigui; Xu, Hai‐Yan; Feng, Xin‐Hong; Ma, Chao‐Mei
Source:
Journal of food science 2019 v.84 no.5 pp. 1224-1230
ISSN:
0022-1147
Subject:
licorice,   etc   ; Glycyrrhiza uralensis; aerial parts; alpha-glucosidase; bioactive compounds; chromatography; enzyme activity; enzyme inhibition; ethanol; fibrosis; inhibitory concentration 50; leaves; liver; quercetin; spectroscopy;     Show all 15 Subjects
Abstract:
... Glycyrrhiza uralensis is the major plant source of licorice. This study was to identify bioactive compounds from the plant's leaves in order to make better use of its aerial part. An ethanol extract of the leaves was subjected to repeated chromatography to yield 15 compounds. The structures were determined to be three novel dihydrostilbenes, based on their various spectroscopic data—glycypytilbene ...
DOI:
10.1111/1750-3841.14592

19. Glabridin inhibits dexamethasone-induced muscle atrophy

Author:
Yoshioka, Yasukiyo; Kubota, Yusuke; Samukawa, Yumi; Yamashita, Yoko; Ashida, Hitoshi
Source:
Archives of biochemistry and biophysics 2019 v.664 pp. 157-166
ISSN:
0003-9861
Subject:
licorice,   etc   ; dexamethasone; glucocorticoid receptors; ingredients; isoflavones; mice; muscles; muscular atrophy; myotubes; oils; oral administration; phosphorylation; protein degradation; quality of life; skeletal muscle; ubiquitin-protein ligase;     Show all 16 Subjects
Abstract:
... Prevention of muscle wasting is known to contribute to improving the quality of life and extending a healthy life. Recently, we have reported that licorice flavonoid oil containing glabridin, which is a prenylated isoflavone, enhances muscle mass in mice. In this study, we investigated the prevention effect of glabridin on dexamethasone-induced muscle atrophy and clarified its mechanism in culture ...
DOI:
10.1016/j.abb.2019.02.006

20. Liquorice (Glycyrrhiza glabra L.) root sherbet (extract): Microencapsulation and storage stability

Author:
Basyigit, B.; Hayoglu, I.
Source:
Acta alimentaria 2019 v.48 no.1 pp. 76-85
ISSN:
1588-2535
Subject:
licorice,   etc   ; Glycyrrhiza glabra; antioxidant activity; emulsions; gum arabic; maltodextrins; microencapsulation; physical properties; powders; response surface methodology; solubility; spray drying; storage quality; water activity; water content; wettability;     Show all 16 Subjects
Abstract:
... The objectives of this study were to produce microencapsulated liquorice root extract (LRE) and determine storage stability of the product obtained. Maltodextrin (MD) and gum arabic (GA) as wall material were used to produce microencapsulated LRE by spray drying technology. Ratio of MD to GA was determined by response surface methodology. Three parameters: microencapsulation yield (MY), microencap ...
DOI:
10.1556/066.2019.48.1.9