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1. Change in the active component of processed Tetradium ruticarpum extracts leads to improvement in efficacy and toxicity attenuation

Author:
Shan, Qiyuan; Tian, Gang; Wang, Juli; Hui, Hui; Shou, Qiyang; Fu, Huiying; Hao, Min; Wang, Kuilong; Wu, Xin; Cao, Gang; Chen, Guanqun; Qin, Luping
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113292
ISSN:
0378-8741
Subject:
licorice,   etc   ; Oriental traditional medicine; Tetradium ruticarpum; acute toxicity; alkaloids; amides; analgesics; animal models; anti-inflammatory activity; bioactive compounds; coumarins; essential oils; ethanol; fruits; gas chromatography-mass spectrometry; indoles; limonoids; manufacturing; medicinal plants; mice; oils; plant extracts; quality control; quinolones; smell; stir frying; ultra-performance liquid chromatography; volatile compounds;     Show all 28 Subjects
Abstract:
... The dried and nearly ripe fruits of Tetradium ruticarpum (A. Juss.) T.G. Hartley (TR) have long been used in treating headache and gastrointestinal disorders in oriental medicine. TR is usually processed by stir-frying with licorice extract before use. Although processing procedure is considered as the way to relieve pungent smell, reduce toxicity, and improve efficacy, its effects on TR's toxicit ...
DOI:
10.1016/j.jep.2020.113292

2. Production and characterization of organic manure from liquorice residues

Author:
Mouhamad, Raghad S.; Mohammed, Zainab J.; Abdulhadi, Ahmad A.; Abbas, Mazhar; Iqbal, Munawar; Nazir, Arif
Source:
Information processing in agriculture 2020 v.7 no.2 pp. 233-241
ISSN:
2214-3173
Subject:
licorice,   etc   ; agricultural wastes; carbon nitrogen ratio; composts; electrical conductivity; fermentation; mineral content; nitrogen; pH;     Show all 9 Subjects
Abstract:
... In present investigation, organic manure was produced and characterized from liquorice residues using activated Effective Microoganism (AEM). The liquorice waste residues were fermented for the period of 6 months in the presence of activated AEM at the rate of 2.5% and 5% of total fermented mixture. Nitrogen (62.5 g) was used per 10 kg of liquorice and moister was maintained at 55–60% during ferme ...
DOI:
10.1016/j.inpa.2019.09.004

3. Liquiritigenin suppresses the activation of hepatic stellate cells via targeting miR-181b/PTEN axis

Author:
Geng, Wujun; Zhou, Guangyao; Zhao, Binyu; Xiao, Qingqing; Li, Chunxue; Fan, Sinuo; Dong, Peihong; Zheng, Jianjian
Source:
Phytomedicine 2020 v.66 pp. 153108
ISSN:
0944-7113
Subject:
licorice,   etc   ; antineoplastic activity; antioxidants; carbon tetrachloride; cell proliferation; collagen; curcumin; drugs; enzymes; liver cirrhosis; mice;     Show all 11 Subjects
Abstract:
... Liquiritigenin (LQ), an aglycone of liquiritin in licorice, has demonstrated antioxidant, anti-inflammatory and anti-tumor activities. Previously, LQ was found to inhibit liver fibrosis progression.Phosphatase and tensin homolog (PTEN) has been reported to act as a negative regulator of hepatic stellate cell (HSC) activation. However, the roles of PTEN in the effects of LQ on liver fibrosis have n ...
DOI:
10.1016/j.phymed.2019.153108

4. Quality assessment of licorice (Glycyrrhiza glabra L.) from different sources by multiple fingerprint profiles combined with quantitative analysis, antioxidant activity and chemometric methods

Author:
Yang, Fangliang; Chu, Tiantian; Zhang, Yujing; Liu, Xitong; Sun, Guoxiang; Chen, Zhenhong
Source:
Food chemistry 2020 v.324 pp. 126854
ISSN:
0308-8146
Subject:
licorice,   etc   ; Fourier transform infrared spectroscopy; Glycyrrhiza glabra; antioxidant activity; chemometrics; food quality; habitats; high performance liquid chromatography; ingredients; quantitative analysis;     Show all 10 Subjects
Abstract:
... Licorice, as a nutritional plant extensively used in food fields, grows in various origins of the world as wild and cultivated types. But existing methods were not adequate for quality estimation of licorice samples from multiple sources till date. In the present research, HPLC, UV and FT-IR were applied together to establish fingerprint profiles of licorice (Glycyrrhiza glabra L.) samples. Then, ...
DOI:
10.1016/j.foodchem.2020.126854

5. Development of 31 EST-SNP markers in Glycyrrhiza uralensis Fisch (Leguminosae) based on transcriptomics

Author:
Hu, Weiming
Source:
Conservation genetics resources 2020 v.12 no.2 pp. 219-223
ISSN:
1877-7252
Subject:
licorice,   etc   ; Glycyrrhiza uralensis; endangered species; genetic structure; genetic variation; heterozygosity; medicinal plants; population structure; single nucleotide polymorphism; transcriptomics; China;     Show all 11 Subjects
Abstract:
... Ural licorice, Glycyrrhiza uralensis Fisch (Leguminosae), is an economically important and endangered medicinal plant species in China. Understanding of population genetic structure using single nucleotide polymorphisms (SNPs) will provide valuable knowledge for the conservation and sustainable utilization of the Ural licorice. Base on the transcriptomic data of G. uralensis, a total of 30,030 pot ...
DOI:
10.1007/s12686-019-01101-2

6. Classification of Flavonoid Metabolomes via Data Mining and Quantification of Hydroxyl NMR Signals

Author:
Yu, Yang; Pauli, Guido F.; Huang, Lingyi; Gan, Li-She; van Breemen, Richard B.; Li, Dianpeng; McAlpine, James B.; Lankin, David C.; Chen, Shao-Nong
Source:
Analytical chemistry 2020 v.92 no.7 pp. 4954-4962
ISSN:
1520-6882
Subject:
licorice,   etc   ; Glycyrrhiza uralensis; bioactive properties; chalcones; metabolites; metabolome; metabolomics; nuclear magnetic resonance spectroscopy; phenols; quality control; solvents;     Show all 11 Subjects
Abstract:
... Utilizing the distinct HMBC cross-peak patterns of lower-field range (LFR; 11.80–14.20 ppm) hydroxyl singlets, presented NMR methodology characterizes flavonoid metabolomes both qualitatively and quantitatively. It enables simultaneous classification of the structural types of 5-OH flavonoids and biogenetically related 2′-OH chalcones, as well as quantification of individual metabolites from ¹H NM ...
DOI:
10.1021/acs.analchem.9b05084

7. Temporal profiling of simplified lemonade using temporal dominance of sensations and temporal check‐all‐that‐apply

Author:
Wu, Anna Zhenan; Lee, Rachel W.; Calvé, Bénédicte Le; Cayeux, Isabelle
Source:
Journal of sensory studies 2019 v.34 no.6 pp. e12531
ISSN:
0887-8250
Subject:
licorice,   etc   ; citric acid; glycosides; lemons; steviol; sucrose; sweetness; taste;     Show all 8 Subjects
Abstract:
... Given that little is known about how sensory interactions during lemonade consumption unfold over time, we studied the impact of citric acid level and type of sweetener on dynamic perception of simplified lemonade using temporal dominance of sensations (TDS) and temporal check‐all‐that‐apply (TCATA). We found that citric acid level did not impact perception of lemon flavor. Instead, the sweetener ...
DOI:
10.1111/joss.12531

8. Oxidation of Licorice-Root Triterpene-Acid Derivatives by m-Chloroperbenzoic Acid

Author:
Mikhailova, L. R.; Budaev, A. S.; Spirikhin, L. V.; Baltina, L. A.
Source:
Chemistry of natural compounds 2019 v.55 no.1 pp. 88-91
ISSN:
0009-3130
Subject:
licorice,   etc   ; acids; chemical structure; esters; nuclear magnetic resonance spectroscopy; oxidation;     Show all 6 Subjects
Abstract:
... Methyl esters of 3β-O-acetoxy-18βH-olean-12-en-30-oic, 3β-hydroxy-9(11),12(13)-dien-30-oic, and 3β-O-acetoxy-18βH-olean-12-en-30-oic acids were oxidized by meta-chloroperbenzoic acid (m-CPBA) to produce methyl esters of 3β-O-acetoxy-12α,13α-epoxy-18β-oleanan-30-oic and 3β-O-acetoxy-18β-oleanan-12-on-30-oic acids in addition to 3β-hydroxy-12-oxo-18βH-olean-9(11)-en-30-oic and 3β-O-acetoxy-18β-olean ...
DOI:
10.1007/s10600-019-02619-5

9. Effects of enhancement of liquorice plants with dark septate endophytes on the root growth, glycyrrhizic acid and glycyrrhizin accumulation amended with organic residues

Author:
He, Chao; Cui, Jie; Chen, Xiaoyu; Wang, Wenquan; Hou, Junling
Source:
Current plant biology 2020 v.23 pp. 100154
ISSN:
2214-6628
Subject:
licorice,   etc   ; Ascomycota; Glycyrrhiza uralensis; active ingredients; ecological function; endophytes; fungi; glycyrrhizin; host plants; lateral roots; mutualism; nutrient deficiencies; phytomass; root growth; structural equation modeling; tap roots;     Show all 16 Subjects
Abstract:
... Dark septate endophytes (DSE) is a diverse group of Ascomycetes fungi involved in a mutualistic symbiosis with plant roots, however, their ecological roles need further clarification. This study aimed to investigate how DSE (Acrocalymma vagum and Paraboeremia putaminum) affect liquorice (Glycyrrhiza uralensis) growth under additional sterilized fermented and unfermented organic residues. Two DSE s ...
DOI:
10.1016/j.cpb.2020.100154

10. Metabolic profiling of mice plasma, bile, urine and feces after oral administration of two licorice flavonones

Author:
Zhang, Lin; Wang, Chen-xiang; Wu, Jing; Wang, Tian-Yun; Zhong, Qiao-Qiao; Du, Yan; Ji, Shuai; Wang, Liang; Guo, Meng-Zhe; Xu, Sheng-Qiu; Tang, Dao-Quan
Source:
Journal of ethnopharmacology 2020 v.257 pp. 112892
ISSN:
0378-8741
Subject:
licorice,   etc   ; antioxidants; apigenin; bile; cosmetics; feces; ions; liquid chromatography; luteolin; mass spectrometry; medicinal plants; metabolism; metabolites; metabolomics; mice; oral administration; quercetin; reference standards; traditional medicine; urine;     Show all 20 Subjects
Abstract:
... Licorice is an ancient food and medicinal plant. Liquiritigenin and liquiritin, two kinds of major flavonoes in licorice, are effective substances used as antioxidant, anti-inflammatory and tumor-suppressive food, cosmetics or medicines. However, their in vivo metabolites have not been fully explored.To clarify the metabolism of liquiritigenin and liquiritin in mice.In this study, we developed a l ...
DOI:
10.1016/j.jep.2020.112892

11. Glycyrrhizin-induced changes in phospholipid dynamics studied by 1H NMR and MD simulation

Author:
Selyutina, O.Yu; Shelepova, E.A.; Paramonova, E.D.; Kichigina, L.A.; Khalikov, S.S.; Polyakov, N.E.
Source:
Archives of biochemistry and biophysics 2020 v.686 pp. 108368
ISSN:
0003-9861
Subject:
licorice,   etc   ; bioactive properties; drug delivery systems; glycyrrhizin; ions; lipid bilayers; lipid composition; nuclear magnetic resonance spectroscopy; permeability; phase transition; phospholipids; proteins; saponins; temperature; traditional medicine;     Show all 15 Subjects
Abstract:
... Phospholipid bilayer constitutes the basis of the cell membrane. Any changes in its structure and dynamics could significantly affect the properties and functions of the cell membrane and associated proteins. It could, in its turn, affect the mechanism and strength of drug-membrane interaction. Phase transitions in lipid bilayer play an important role in cell life and in transmembrane transport of ...
DOI:
10.1016/j.abb.2020.108368

12. Determination of ochratoxin A in pork meat products: single laboratory validation method and preparation of homogeneous batch materials

Author:
De Santis, Barbara; Gregori, Emanuela; Debegnach, Francesca; Moracci, Gabriele; Saitta, Chiara; Brera, Carlo
Source:
Mycotoxin research 2020 v.36 no.2 pp. 235-241
ISSN:
0178-7888
Subject:
licorice,   etc   ; Aspergillus carbonarius; Aspergillus niger; Aspergillus ochraceus; Penicillium verrucosum; beers; grains; ham; high performance liquid chromatography; kidneys; liver; normal values; ochratoxin A; organ meats; spices; wines;     Show all 16 Subjects
Abstract:
... Ochratoxin A is one of the most diffused mycotoxin present in a large spectrum of food commodities, mainly produced by Aspergillus ochraceus, Aspergillus carbonarius, Aspergillus niger and Penicillium verrucosum. EU has set maximum limits for a number of matrices such as cereals, wine, spices and liquorice, whilst other commodities such as beer and meat products that are susceptible of OTA contami ...
DOI:
10.1007/s12550-020-00386-9

13. Fractionation and precipitation of licorice (Glycyrrhiza glabra L.) phytochemicals by supercritical antisolvent (SAS) technique

Author:
Quintana, Somaris E.; Hernández, Diego Martín; Villanueva-Bermejo, David; García-Risco, Mónica R.; Fornari, Tiziana
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2020 v.126 pp. 109315
ISSN:
0023-6438
Subject:
licorice,   etc   ; Glycyrrhiza glabra; antioxidant activity; bioactive compounds; byproducts; carbon dioxide; food matrix; fractionation; glycyrrhizin; ingredients; oleoresins; particle size; phenolic compounds; phytochemicals; powders; temperature;     Show all 16 Subjects
Abstract:
... Supercritical anti-solvent precipitation (SAS) using carbon dioxide is a novel technique that can be used to produce powdered ingredients in small size particles, facilitating their incorporation into food matrices. In this work, the SAS precipitation of a licorice root ethanolic extract was studied. SAS assays were carried out at 15–20 MPa, 308.15 and 313.15 K, and two different concentrations (9 ...
DOI:
10.1016/j.lwt.2020.109315

14. Zingiber officinale and Glycyrrhiza glabra, individually or in combination, reduce heavy metal accumulation and improve growth performance and immune status in Nile tilapia, Oreochromis niloticus

Author:
Mohammed, Eman; Kamel, Mervat; El Iraqi, Kassem; Tawfik, Azza M.; Khattab, Marwa S.; Elsabagh, Mabrouk
Source:
Aquaculture research 2020 v.51 no.5 pp. 1933-1941
ISSN:
1355-557X
Subject:
licorice,   etc   ; Glycyrrhiza glabra; Oreochromis niloticus; Zingiber officinale; albumins; creatinine; feed conversion; fingerlings; gills; ginger; globulins; growth performance; heavy metals; hematocrit; hemoglobin; histopathology; intestines; necrosis; neutrophils; urea nitrogen; villi;     Show all 21 Subjects
Abstract:
... This study evaluated the impact of dietary ginger and liquorice supplementation on growth performance, physiological and histopathological profiles and heavy metal accumulation in Nile tilapia fingerlings. Fish (n = 1,800, 17.5 ± 0.11 g BW) were randomly distributed into four treatment groups in triplicates and received no supplementation (control group), 5 ml aqueous ginger extract/kg feed (ginge ...
DOI:
10.1111/are.14544

15. Metabolomics study of different parts of licorice from different geographical origins and their anti‐inflammatory activities

Author:
Bai, Haiying; Bao, Fang; Fan, Xiaorui; Han, Shu; Zheng, Wenhui; Sun, Lili; Yan, Na; Du, Hong; Zhao, Haiyu; Yang, Zhigang
Source:
Journal of separation science 2020 v.43 no.8 pp. 1593-1602
ISSN:
1615-9306
Subject:
licorice,   etc   ; Glycyrrhiza uralensis; Oriental traditional medicine; anti-inflammatory activity; bioactive compounds; biomarkers; liquid chromatography; metabolomics; methylation; provenance; tandem mass spectrometry; tap roots; China;     Show all 13 Subjects
Abstract:
... Glycyrrhiza uralensis Fisch., known as licorice, is one of the most famous traditional Chinese medicines. In this study, we perform a metabolome analysis using liquid chromatography–tandem mass spectrometry to assign bioactive components in different parts of licorice from different geographical origins in Gansu province of China. Sixteen potential biomarkers of taproots from different geographica ...
DOI:
10.1002/jssc.201901013

16. Fabricating cellulose nanofibril from licorice residues and its cellulose composite incorporated with natural nanoparticles

Author:
Wang, Si; Wang, Xiao; Liu, Wei; Zhang, Liguo; Ouyang, Hao; Hou, Qingxi; Fan, Kejing; Li, Jinsong; Liu, Pengtao; Liu, Xinliang
Source:
Carbohydrate polymers 2020 v.229 pp. 115464
ISSN:
0144-8617
Subject:
licorice,   etc   ; biomass; bleaching; cellulose; chitosan; composite films; composite materials; crystal structure; homogenization; hydrophobicity; lignin; mechanical properties; nanofibers; nanoparticles; oxidation; peracetic acid; pulp; pulping; quinones; thermal stability; transmittance;     Show all 21 Subjects
Abstract:
... It is important to make full utilization of industrial biomass residues. Pulp was prepared from licorice residues by soda-anthraquinone pulping followed by peroxyacetic acid bleaching. Cellulose nanofibril was obtained by enzymatic pretreatment followed by homogenization of the pulp (ETCNF). The effects of enzymatic pretreatment on ETCNF were investigated. Chitosan nanofibril (CHN) and lignin nano ...
DOI:
10.1016/j.carbpol.2019.115464

17. Investigations into the structure-function relationship of plant-based surfactant glycyrrhizin: Interfacial behavior & emulsion formation

Author:
Ralla, Theo; Salminen, Hanna; Braun, Katharina; Edelmann, Matthias; Dawid, Corinna; Hofmann, Thomas; Weiss, Jochen
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2020 v.120 pp. 108910
ISSN:
0023-6438
Subject:
licorice,   etc   ; Glycyrrhiza glabra; beverages; cosmetics; emulsifying; emulsifying properties; emulsions; glycyrrhizin; homogenization; hydrophobic bonding; hydrophobicity; molecular models; oil-water interface; oils; pH; saponins; structure-activity relationships; surfactants; viscoelasticity;     Show all 19 Subjects
Abstract:
... This study describes the interfacial and emulsifying properties of a plant-based saponin glycyrrhizin and its aglycone 18β-glycyrrhetinic acid derived from licorice root (Glycyrrhiza glabra L.) to enable first insights into a potential structure-function relationship. First, the surface activity of glycyrrhizin and its aglycone at air-water and oil-water interfaces, and the viscoelastic behavior a ...
DOI:
10.1016/j.lwt.2019.108910

18. Synergistic anti-colon cancer effect of glycyrol and butyrate is associated with the enhanced activation of caspase-3 and structural features of glycyrol

Author:
Lu, Shangyun; Yin, Shutao; Zhao, Chong; Fan, Lihong; Hu, Hongbo
Source:
Food and chemical toxicology 2020 v.136 pp. 110952
ISSN:
0278-6915
Subject:
licorice,   etc   ; antineoplastic activity; antineoplastic agents; butyrates; caspase-3; colon; colorectal neoplasms; coumarin; coumestrol; furans; intestinal microorganisms; neoplasm cells; short chain fatty acids;     Show all 13 Subjects
Abstract:
... Coumarin-based anti-cancer agents have attracted considerable attention recently. Butyrate, a major short-chain fatty acid produced in colon by gut microbiota, has been shown to exert anticancer activity both in vitro and in vivo. In this study, we evaluated the anti-cancer effect of combining glycyrol (GC), a representative of coumarin compounds in licorice, or its analogues Glycycoumarin/Demethy ...
DOI:
10.1016/j.fct.2019.110952

19. Inhibition of human thrombin by the constituents of licorice: inhibition kinetics and mechanistic insights through in vitro and in silico studies

Author:
Shi, Cheng-Cheng; Chen, Tian-Ran; Zhang, Qi-Hua; Wei, Ling-Hua; Huang, Chao; Zhu, Ya-Di; Liu, Hai-Bin; Bai, Ya-Kun; Wang, Fang-Jun; Guo, Wen-Zhi; Zhang, Li-Rong; Ge, Guang-Bo
Source:
RSC advances 2020 v.10 no.7 pp. 3626-3635
ISSN:
2046-2069
Subject:
licorice,   etc   ; acetates; active sites; blood coagulation; catalytic activity; chalcones; computer simulation; enzyme inhibition; enzyme inhibitors; humans; hydrolysis; inhibitory concentration 50; mass spectrometry; risk; therapeutics; thrombin;     Show all 16 Subjects
Abstract:
... Thrombin inhibition therapy is a practical strategy to reduce thrombotic and cardiovascular risks via blocking the formation of blood clots. This study aimed to identify naturally occurring thrombin inhibitors from licorice (one of the most popular edible herbs), as well as to investigate their inhibitory mechanisms. Among all tested licorice constituents, licochalcone A was found as the most effi ...
DOI:
10.1039/c9ra09203j

20. Hydrothermal deglycosylation and deconstruction effect of steam explosion: application to high-valued glycyrrhizic acid derivatives from liquorice

Author:
Sui, Wenjie; Zhou, Mengjia; Xu, Yi; Wang, Guanhua; Zhao, Huan; Lv, Xiaoling
Source:
Food chemistry 2019
ISSN:
0308-8146
Subject:
licorice,   etc   ; autohydrolysis; bioactive compounds; diffusivity; endothermy; glucuronic acid; glycosidic linkages; glycyrrhetinic acid; glycyrrhizin; reaction kinetics; thermodynamics;     Show all 11 Subjects
Abstract:
... In this work, steam explosion (SE) was exploited as a green and facile process to deconstruct liquorice’s structure and deglycosylate glycyrrhizic acid (GL) to improve conversion and diffusion efficacy of GL and its hydrolyzed products. Results showed SE induced auto-hydrolysis of GL into glycyrrhetic acid 3-O-mono-β-D-glucuronide (GAMG) and glycyrrhetinic acid (GA), by which 30.71% of GL conversi ...
DOI:
10.1016/j.foodchem.2019.125558