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1. NUCB2/nesfatin-1 – Inhibitory effects on food intake, body weight and metabolism

Author:
Schalla, Martha A.; Unniappan, Suraj; Lambrecht, Nils W.G.; Mori, Masatomo; Taché, Yvette; Stengel, Andreas
Source:
Peptides 2020 v.128 pp. 170308
ISSN:
0196-9781
Subject:
lipid metabolism,   etc   ; body weight; food intake; glucose;     Show all 4 Subjects
Abstract:
... Since its discovery in 2006 by Oh-I and colleagues, NUCB2/nesfatin-1 encoded by nucleobindin-2 (NUCB2) has drawn sustained attention as reflected in over 500 publications. Among those, more than half focused on the alterations of food intake, body weight and metabolism (glucose, fat) induced by nesfatin-1 and/or NUCB2/nesfatin-1. In the current review we discuss the existing literature focusing on ...
DOI:
10.1016/j.peptides.2020.170308

2. Light-Up Lipid Droplets Dynamic Behaviors Using a Red-Emitting Fluorogenic Probe

Author:
Zhang, Xin; Yuan, Lin; Jiang, Jianxia; Hu, Jiwen; du Rietz, Anna; Cao, Hongzhi; Zhang, Ruilong; Tian, Xiaohe; Zhang, Fengling; Ma, Yuguang; Zhang, Zhongping; Uvdal, Kajsa; Hu, Zhangjun
Source:
Analytical chemistry 2020 v.92 no.5 pp. 3613-3619
ISSN:
1520-6882
Subject:
lipid metabolism,   etc   ; droplets; fluorescent dyes; image analysis; lipids; lipotoxicity; photobleaching;     Show all 7 Subjects
Abstract:
... Intracellular lipid metabolism occurs in lipid droplets (LDs), which is critical to the survival of cells. Imaging LDs is an intuitive way to understand their physiology in live cells. However, this is limited by the availability of specific probes that can properly visualize LDs in vivo. Here, an LDs-specific red-emitting probe is proposed to address this need, which is not merely with an ultrahi ...
DOI:
10.1021/acs.analchem.9b04410

3. Specialized ER membrane domains for lipid metabolism and transport

Author:
Nishimura, Taki; Stefan, Christopher J.
Source:
Biochimica et biophysica acta 2020 v.1865 no.1 pp. 158492
ISSN:
1388-1981
Subject:
lipid metabolism,   etc   ; biosynthesis; endoplasmic reticulum; enzymes; lipid transfer proteins; lipids;     Show all 6 Subjects
Abstract:
... The endoplasmic reticulum (ER) is a highly organized organelle that performs vital functions including de novo membrane lipid synthesis and transport. Accordingly, numerous lipid biosynthesis enzymes are localized in the ER membrane. However, it is now evident that lipid metabolism is sub-compartmentalized within the ER and that lipid biosynthetic enzymes engage with lipid transfer proteins (LTPs) ...
DOI:
10.1016/j.bbalip.2019.07.001

4. An update on the potential role of advanced glycation end products in glycolipid metabolism

Author:
Wang, Xiaolei; Liu, Junjun; Yang, Ying; Zhang, Xiandang
Source:
Life sciences 2020 v.245 pp. 117344
ISSN:
0024-3205
Subject:
lipid metabolism; lipid metabolism disorders,   etc   ; advanced glycation end products; animal models; atherosclerosis; diabetes; glucose; glycolipids; hyperglycemia; insulin resistance; pathogenesis; pathophysiology; receptors; therapeutics;     Show all 14 Subjects
Abstract:
... Advanced glycation end products (AGEs) play a crucial role in many major diseases, such as diabetes and atherosclerosis. AGE accumulation in the body is generally considered a consequence of hyperglycaemia. However, recent studies have shown that AGEs may also be an important cause of the initial pathogenesis of diabetes and atherosclerosis. The objective of the present review is to provide an upd ...
DOI:
10.1016/j.lfs.2020.117344

5. PM2.5 exposure induces age-dependent hepatic lipid metabolism disorder in female mice

Author:
Yan, Ruifeng; Ku, Tingting; Yue, Huifeng; Li, Guangke; Sang, Nan
Source:
Journal of environmental sciences (China) 2020 v.89 pp. 227-237
ISSN:
1001-0742
Subject:
lipid metabolism; lipid metabolism disorders,   etc   ; aerodynamics; animal diseases; body weight; cardiovascular diseases; diet; droplets; females; gene expression; lipids; liver; liver diseases; lungs; mice; particulates; risk; secretion; ultrastructure;     Show all 19 Subjects
Abstract:
... Particulate matter exposure has been described to elevate the risk of lung and cardiovascular diseases. An increasing number of recent studies have indicated positive correlations between PM₂.₅ (the fraction of airborne particles with an aerodynamic diameter less than 2.5 μm) exposure and the risk of liver diseases. However, research on the effects of PM₂.₅ exposure on liver fat synthesis, secreti ...
DOI:
10.1016/j.jes.2019.10.014

6. Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5

Author:
Zhang, Yuezhu; Zhou, Liting; Zhang, Zhaoming; Xu, Qi; Han, Xu; Zhao, Yaming; Song, Xinyue; Zhao, Tianyang; Ye, Lin
Source:
Environmental science and pollution research international 2020 v.27 no.4 pp. 3837-3848
ISSN:
0944-1344
Subject:
lipid metabolism; lipid metabolism disorders,   etc   ; adipogenesis; high fat diet; lipids; liver; messenger RNA; non-specific protein-tyrosine kinase; phthalates; protein content; rats; toxicity; weight gain;     Show all 13 Subjects
Abstract:
... Exposure to di (2-ethylhexyl) phthalate (DEHP) induces lipid metabolism disorder and high-fat diet (HD) may have joint effects with DEHP. We aim to clarify the role of JAK2/STAT5 pathway in the process and reveal the effects of HD on the toxicity of DEHP. Wistar rats (160 animals) were fed with HD or normal diet (ND) respectively and exposed to DEHP 0, 5, 50, and 500 mg/kg/day for 8 weeks. Lipid l ...
DOI:
10.1007/s11356-019-06599-5

7. Roadmap to pregnancy during the period of maternal recognition in the cow: Changes within the corpus luteum associated with luteal rescue

Author:
Pate, Joy L.
Source:
Theriogenology 2020 v.150 pp. 294-301
ISSN:
0093-691X
Subject:
lipid metabolism,   etc   ; blood flow; corpus luteum; cows; longevity; luteolysis; pregnancy; progesterone; prostaglandins; secretion; sheep; uterus;     Show all 12 Subjects
Abstract:
... A viable corpus luteum (CL) producing an adequate amount of progesterone is absolutely essential for establishment and maintenance of pregnancy. One function of embryonic signaling to the mother is to ensure that the CL is maintained. In ruminants, the secretion of uterine prostaglandin F2alpha (PGF2A) is the signal that initiates luteolysis. Despite many studies to determine if PGF2A secretion fr ...
DOI:
10.1016/j.theriogenology.2020.01.074

8. An overlooked danger of ketogenic diets: Making the case that ketone bodies induce vascular damage by the same mechanisms as glucose

Author:
Burkitt, Mark J.
Source:
Nutrition 2020 v.75-76 pp. 110763
ISSN:
0899-9007
Subject:
lipid metabolism,   etc   ; cardiovascular diseases; glucose; ketogenic diet; ketone bodies; ketones; ketosis; proteins; weight loss;     Show all 9 Subjects
Abstract:
... Intense debate surrounds the use of low-carbohydrate, ketogenic diets for the promotion of weight loss and avoidance of cardiovascular disease. The rationale behind these diets is that they promote fat oxidation and minimize the addition of glucose to proteins in the formation of adducts that trigger inflammation.Although nutritional ketosis is widely assumed to be a safe metabolic condition, prop ...
DOI:
10.1016/j.nut.2020.110763

9. Plant unusual fatty acids: learning from the less common

Author:
Cahoon, Edgar B; Li-Beisson, Yonghua
Source:
Current opinion in plant biology 2020 v.55 pp. 66-73
ISSN:
1369-5266
Subject:
lipid metabolism,   etc   ; biosynthesis; cutin; enzymes; fatty acids; metabolic engineering; pathogens; polyesters; seed oils;     Show all 9 Subjects
Abstract:
... The plant kingdom contains an abundance of structurally diverse fatty acids referred to as unusual fatty acids. Unusual fatty acids on plant surfaces can form polyesters that contribute to the function of cutin as a barrier for water loss and pathogen protection. Unusual fatty acids are also found as abundant components of seed oils of selected species and often confer desirable properties for ind ...
DOI:
10.1016/j.pbi.2020.03.007

10. Lipid digestion products in meat derivatives enriched with fish oil microcapsules

Author:
Solomando, Juan Carlos; Antequera, Teresa; Perez-Palacios, Trinidad
Source:
Journal of functional foods 2020 v.68 pp. 103916
ISSN:
1756-4646
Subject:
lipid metabolism,   etc   ; European Union; bioavailability; cured meats; fish oils; intestines; meat; omega-3 fatty acids;     Show all 8 Subjects
Abstract:
... This study analyzes the potential application of monolayered (Mo) and multilayered (Mu) fish oil microcapsules as EPA and DHA vehicles in cooked (C-SAU) and dry-cured (D-SAU) meat products and the bioaccesibility of their fatty acids. The quantities of EPA and DHA in all batches (44–64 mg EPA + DHA/100 g sample) exceeded the level established by the European Union to label a food as “source of ω-3 ...
DOI:
10.1016/j.jff.2020.103916

11. Development of AOP relevant to microplastics based on toxicity mechanisms of chemical additives using ToxCast™ and deep learning models combined approach

Author:
Jeong, Jaeseong; Choi, Jinhee
Source:
Environment international 2020 v.137 pp. 105557
ISSN:
0160-4120
Subject:
lipid metabolism,   etc   ; additives; adverse outcome pathways; databases; durability; genes; inflammation; microplastics; neoplasms; neural networks; neurotoxicity; pollution;     Show all 12 Subjects
Abstract:
... Various additives are used in plastic products to improve the properties and the durability of the plastics. Their possible elution from the plastics when plastics are fragmented into micro- and nano-size in the environment is suspected to one of the major contributors to environmental and human toxicity of microplastics. In this context, to better understand the hazardous effect of microplastics, ...
DOI:
10.1016/j.envint.2020.105557

12. Phospholipid imaging of zebrafish exposed to fipronil using atmospheric pressure matrix-assisted laser desorption ionization mass spectrometry

Author:
Liu, Wenjie; Nie, Hongang; Liang, Dapeng; Bai, Yu; Liu, Huwei
Source:
Talanta 2020 v.209 pp. 120357
ISSN:
0039-9140
Subject:
lipid metabolism,   etc   ; Danio rerio; atmospheric pressure; desorption; eyes; fipronil; fish; image analysis; mass spectrometry; phospholipids; toxicology;     Show all 11 Subjects
Abstract:
... Mass spectrometry imaging can effectively detect and reflect the information of molecular spatial distribution, and has been widely used for in situ analysis of endogenous or exogenous molecules in organisms. The present work applied the atmospheric pressure matrix-assisted laser desorption ionization mass spectrometry (AP-MALDI-MS) in the imaging of whole zebrafish slices exposed to fipronil. The ...
DOI:
10.1016/j.talanta.2019.120357

13. The influence of carbon limitation on growth of Heterosigma akashiwo: A case study in fatty acids composition

Author:
Lou, Yadi; Liu, Yu; Li, Na; Liu, Yuxin; Wang, Guoguang; Zhao, Xinda; Wang, Haixia
Source:
The Science of the total environment 2020 v.706 pp. 135700
ISSN:
0048-9697
Subject:
lipid metabolism,   etc   ; algal blooms; carbon; case studies; fatty acid composition; microalgae; nitrogen; phosphorus; stable isotopes;     Show all 9 Subjects
Abstract:
... Heterosigma akashiwo is an algal blooms species, and thus selected as the target microalgae in this work. This study attempted to investigate the influence of carbon limitation on the growth of H. akashiwo. Experiments were carried out in CO₂-unlimited and CO₂-limited systems (both include three nutritional groups). The stable isotope signatures and compound-specific stable three nutritional group ...
DOI:
10.1016/j.scitotenv.2019.135700

14. A label-free shotgun proteomics analysis of macadamia nut

Author:
Rost, Johanna; Muralidharan, Sridevi; Lee, N. Alice
Source:
Food research international 2020 v.129 pp. 108838
ISSN:
0963-9969
Subject:
lipid metabolism,   etc   ; allergens; amino acid metabolism; antimicrobial peptides; macadamia nuts; proteomics; stress response; vicilin;     Show all 8 Subjects
Abstract:
... In this study, we present a systematic proteomic overview of macadamia nut using a label-free shotgun proteomic approach. We identified 947 proteins in 723 clusters and gene ontology analysis revealed proteins across 46 functional categories including carbohydrate metabolism (10%), protein metabolic processes (5%), amino acid metabolism (4%), transport (4%), stress response (3%), lipid metabolism ...
DOI:
10.1016/j.foodres.2019.108838

15. Shotgun lipidomics-based characterization of the landscape of lipid metabolism in colorectal cancer

Author:
Wang, Yuting; Hinz, Sebastian; Uckermann, Ortrud; Hönscheid, Pia; von Schönfels, Witigo; Burmeister, Greta; Hendricks, Alexander; Ackerman, Jacobo Miranda; Baretton, Gustavo B.; Hampe, Jochen; Brosch, Mario; Schafmayer, Clemens; Shevchenko, Andrej; Zeissig, Sebastian
Source:
Biochimica et biophysica acta 2020 v.1865 no.3 pp. 158579
ISSN:
1388-1981
Subject:
lipid metabolism,   etc   ; biopsy; blood lipids; colorectal neoplasms; gene expression; lipid composition; mucosa; phospholipids; reactive oxygen species;     Show all 9 Subjects
Abstract:
... Solid tumors are characterized by global metabolic alterations which contribute to their growth and progression. Altered gene expression profiles and plasma lipid composition suggested a role for metabolic reprogramming in colorectal cancer (CRC) development. However, a conclusive picture of CRC-associated lipidome alterations in the tumor tissue has not emerged. Here, we determined molar abundanc ...
DOI:
10.1016/j.bbalip.2019.158579

16. Can metabolic thresholds be used as exercise intensity markers in adult men with obesity – fat burn points used as an exercise marker

Author:
Peric, R.; Nikolovski, Z.
Source:
Comparative exercise physiology 2020 v.16 no.2 pp. 113-119
ISSN:
1755-2559
Subject:
lipid metabolism,   etc   ; adults; exercise; males; men; obesity; peak oxygen uptake; t-test;     Show all 8 Subjects
Abstract:
... We aimed to determine the exercise intensity eliciting the highest (FATₘₐₓ) and the lowest (FATₘᵢₙ) fat oxidation rate in sedentary men with obesity and to examine if these intensities correlate with their individual aerobic (AeT) and anaerobic (AnT) thresholds, respectively. Nineteen obese males performed breath-by-breath analysis to assess maximal oxygen consumption (VO₂ₘₐₓ) and to calculate the ...
DOI:
10.3920/CEP190035

17. Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view

Author:
Ferreira, Vitor; Grajales, Diana; Valverde, Ángela M.
Source:
Biochimica et biophysica acta 2020 v.1865 no.2 pp. 158534
ISSN:
1388-1981
Subject:
lipid metabolism,   etc   ; adipocytes; adipose tissue; adverse effects; antipsychotics; hyperglycemia; hyperlipidemia; patients; schizophrenia; weight gain;     Show all 10 Subjects
Abstract:
... Schizophrenia is a neuropsychiatric disorder that chronically affects 21 million people worldwide. Second-generation antipsychotics (SGAs) are the cornerstone in the management of schizophrenia. However, despite their efficacy in counteracting both positive and negative symptomatology of schizophrenia, recent clinical observations have described an increase in the prevalence of metabolic disturban ...
DOI:
10.1016/j.bbalip.2019.158534

18. Correction to: Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5

Author:
Zhang, Yuezhu; Zhou, Liting; Zhang, Zhaoming; Xu, Qi; Han, Xu; Zhao, Yaming; Song, Xinyue; Zhao, Tianyang; Ye, Lin
Source:
Environmental science and pollution research international 2020 v.27 no.4 pp. 3849
ISSN:
0944-1344
Subject:
lipid metabolism,   etc   ; anesthesia; anesthetics; high fat diet; non-specific protein-tyrosine kinase; pentobarbital; phthalates; rats;     Show all 8 Subjects
Abstract:
... We found an error in the materials and methods section. Since our team used two methodsfor anesthesia in rats and the anesthesia method used in this paper was 3.5% chloralhydrate anesthesia, we mistakenly wrote the anesthetic as 3% sodium pentobarbital. ...
DOI:
10.1007/s11356-019-07442-7

19. Postprandial Lipemia Modulates Pancreatic Alpha-Cell Function in the Prediction of Type 2 Diabetes Development: The CORDIOPREV Study

Author:
Pozuelo-Sanchez, Isabel; Villasanta-Gonzalez, Alejandro; Alcala-Diaz, Juan Francisco; Vals-Delgado, Cristina; Leon-Acuña, Ana; Gonzalez-Requero, Anabel; Yubero-Serrano, Elena Maria; Luque, Raul Miguel; Caballero-Villarraso, Javier; Quesada, Ivan; Ordovas, José María; Pérez-Martinez, Pablo; Roncero-Ramos, Irene; Lopez-Miranda, Jose
Source:
Journal of agricultural and food chemistry 2020 v.68 no.5 pp. 1266-1275
ISSN:
1520-5118
Subject:
lipid metabolism,   etc   ; confidence interval; glucagon; hyperlipidemia; noninsulin-dependent diabetes mellitus; nutritional intervention; patients; prediction; triacylglycerols;     Show all 9 Subjects
Abstract:
... Diabetes (T2DM) is a major global health issue, and developing new approaches to its prevention is of paramount importance. We hypothesized that abnormalities in lipid metabolism are involved in alpha-cell deregulation. We therefore studied the metabolic factors underlying alpha-cell dysfunction in T2DM progression after a dietary intervention (Mediterranean and low-fat). Additionally, we evaluate ...
DOI:
10.1021/acs.jafc.9b06801

20. The effects of a pre-exercise meal on postexercise metabolism following a session of sprint interval training

Author:
Broad, Abigail A.; Howe, Greg J.; McKie, Greg L.; Vanderheyden, Luke W.; Hazell, Tom J.
Source:
Applied physiology, nutrition and metabolism 2020 v.45 no.4 pp. 411-420
ISSN:
1715-5320
Subject:
lipid metabolism,   etc   ; appetite; energy expenditure; energy intake; exercise; gas exchange; males;     Show all 7 Subjects
Abstract:
... Sprint interval training (SIT) has demonstrated reductions in fat mass through potential alterations in postexercise metabolism. This study examined whether exercising in the fasted or fed state affects postexercise metabolism following acute SIT. Ten active males performed a bout of modified SIT (8 × 15-s sprints; 120 s recovery) in both a fasted (FAST) and fed (FED) state. Gas exchange was colle ...
DOI:
10.1139/apnm-2019-0510