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- Author:
- Ji-Yoon Lee; Won Kon Kim; Kwang-Hee Bae; Sang Chul Lee; Eun-Woo Lee
- Source:
- Biology 2021 v.10 no.3 pp. -
- ISSN:
- 2079-7737
- Subject:
- lipid metabolism, etc ; biosynthesis; blood; cell membranes; ferroptosis; lipid peroxidation; lymph; necrosis; phosphatidylcholines; phosphatidylethanolamines; Show all 10 Subjects
- Abstract:
- ... and signaling pathways. In this review, we summarize our current knowledge of how various lipid metabolic pathways are associated with lipid peroxidation and ferroptosis. Our review will provide insight into treatment strategies for ferroptosis-related diseases. ...
- DOI:
- 10.3390/biology10030184
- https://doi.org/10.3390/biology10030184
- Author:
- Jie Gao; Manqian Zhang; Ruixue Niu; Xue Gu; Erwei Hao; Xiaotao Hou; Jiagang Deng; Gang Bai
- Source:
- Journal of functional foods 2021 v.83 pp. 104556
- ISSN:
- 1756-4646
- Subject:
- AMP-activated protein kinase; amino acid metabolism; diabetes; energy; fatty acids; flavor compounds; gluconeogenesis; glucose; glycolysis; kaempferol; lipolysis; metabolomics
- Abstract:
- ... acid synthesis both in vivo and in vitro. In conclusion, this study indicated that the CA and KP combination ameliorated glucose and lipid metabolism disorders by enhancing lipid metabolism via the activation of AMPK. ...
- DOI:
- 10.1016/j.jff.2021.104556
- https://doi.org/10.1016/j.jff.2021.104556
- Author:
- Yong Zhou; Juan Pu; Yuping Wu
- Source:
- Pathogens 2021 v.10 no.3 pp. -
- ISSN:
- 2076-0817
- Subject:
- lipid metabolism, etc ; Influenza A virus; cholesterol; death; fatty acids; glycolipids; pathogens; phospholipids; poultry; public health; viruses; Show all 11 Subjects
- Abstract:
- ... Influenza A virus (IAV) is an important zoonotic pathogen that can cause disease in animals such as poultry and pigs, and it can cause infection and even death in humans, posing a serious threat to public health. IAV is an enveloped virus that relies on host cell metabolic systems, especially lipid metabolism systems, to complete its life cycle in host cells. On the other side, host cells ...
- DOI:
- 10.3390/pathogens10030303
- https://doi.org/10.3390/pathogens10030303
- Author:
- Jerome E. Tanner; Caroline Alfieri
- Source:
- Viruses 2021 v.13 no.1 pp. -
- ISSN:
- 1999-4915
- Subject:
- AMP-activated protein kinase; COVID-19 infection; Orthocoronavirinae; disease severity; fatty acids; fatty-acid synthase; homeostasis; immune response; inflammation; intestines; liver; metformin; palmitoylation; pancreas; patients; therapeutics; virus replication
- Abstract:
- ... Enteric symptomology seen in early-stage severe acute respiratory syndrome (SARS)-2003 and COVID-19 is evidence of virus replication occurring in the intestine, liver and pancreas. Aberrant lipid metabolism in morbidly obese individuals adversely affects the COVID-19 immune response and increases disease severity. Such observations are in line with the importance of lipid metabolism in COVID-19 ...
- DOI:
- 10.3390/v13010090
- https://doi.org/10.3390/v13010090
- Author:
- Tianci Jiang; Lingling Dai; Pengfei Li; Junwei Zhao; Xi Wang; Lin An; Meng Liu; Shujun Wu; Yu Wang; Youmei Peng; Di Sun; Caopei Zheng; Tingting Wang; Xuejun Wen; Zhe Cheng
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.2 pp. 158853
- ISSN:
- 1388-1981
- Subject:
- lipid metabolism, etc ; asthma; biomarkers; blood lipids; ceramides; energy; lipid composition; lipidomics; liquid chromatography; lysophosphatidylcholine; mass spectrometry; metabolites; phosphatidylethanolamines; signal transduction; sphingomyelins; triacylglycerols; Show all 16 Subjects
- Abstract:
- ... Lipids participate in many important biological functions through energy storage, material transport, signal transduction, and molecular recognition processes. Studies have reported that asthmatic patients have abnormal lipid metabolism. However, there are limited studies on the characterization of lipid metabolism in asthmatic patients by lipidomics.We characterized the plasma lipid profile ...
- DOI:
- 10.1016/j.bbalip.2020.158853
- https://doi.org/10.1016/j.bbalip.2020.158853
- Author:
- Jinhong Wu; Qiaoyu Wu; Danlu Yang; Mi Zhou; Jingshen Xu; Qing Wen; Yan Cui; Yalong Bai; Shannan Xu; Zhengwu Wang; Shaoyun Wang
- Source:
- Food chemistry 2021 v.344 pp. 128661
- ISSN:
- 0308-8146
- Subject:
- lipid metabolism, etc ; Aleuria; Danio rerio; absorption; amino acid composition; arabinose; carboxylic ester hydrolases; catabolism; degradation; drugs; essential amino acids; food chemistry; fucose; galactose; glucose; glycoproteins; lectins; lipids; mannose; patatin; protein sources; rhamnose; xylose; Show all 23 Subjects
- Abstract:
- ... Patatin, the major protein found in potatoes, was purified and shows several isoforms. The essential amino acid content of patatin was ashighas 76%, indicating that it is a valuable protein source. Patatin was an O-linked glycoprotein that contained fucose monosaccharides, as well as mannose, rhamnose, glucose, galactose, xylose, and arabinose. Patatin had a fucosylated glycan structural feature, ...
- DOI:
- 10.1016/j.foodchem.2020.128661
- https://doi.org/10.1016/j.foodchem.2020.128661
- Author:
- Xu Zhao; Huashan Huang; Xiao Ding; Zaibin Yang; Yanru Hou; Hongfang Wang
- Source:
- Poultry science 2021 v.100 no.7 pp. 101159
- ISSN:
- 0032-5791
- Subject:
- lipid metabolism, etc ; blood serum; breast muscle; carnitine palmitoyltransferase; cell viability; coculture; cytotoxicity; free fatty acids; gene expression; intravenous injection; lipoprotein lipase; males; myoblasts; triacylglycerol lipase; triacylglycerols; Show all 15 Subjects
- Abstract:
- ... The objective of this study was to determine the effects of angiopoietin-like protein 4 (ANGPTL4) on breast muscle lipid metabolism in broilers. In experiment 1, 36 thirty-five-day-old male Arbor Acres broilers were randomly allocated into 6 treatment groups with 6 birds in a completely randomized design. The broilers were subjected to intravenous injection of His-SUMO-ANGPTL4 at the dose of 0 ...
- DOI:
- 10.1016/j.psj.2021.101159
- https://doi.org/10.1016/j.psj.2021.101159
- Author:
- Fan Xiong; Lu Cao; Xiao Man Wu; Ming Xian Chang
- Source:
- Developmental and comparative immunology 2021 v.116 pp. 103955
- ISSN:
- 0145-305X
- Subject:
- lipid metabolism, etc ; Carp sprivivirus; Danio rerio; Edwardsiella piscicida; antibacterial properties; antiviral properties; bile; bile acids; biosynthesis; dose response; energy; fish; glucose; glycerophospholipids; homeostasis; lipidomics; mammals; transcriptomics; transportation; Show all 19 Subjects
- Abstract:
- ... G protein-coupled bile acids receptor 1 (GPBAR1 or TGR5) has been widely studied as a metabolic regulator involved in bile acids synthesis, glucose metabolism and energy homeostasis. Several recent studies have shown that mammalian GPBAR1 is also involved in antiviral innate immune responses. However, the functions of piscine GPBAR1 in antibacterial or antiviral immune responses and lipid ...
- DOI:
- 10.1016/j.dci.2020.103955
- https://doi.org/10.1016/j.dci.2020.103955
9. Glyphosate-induced lipid metabolism disorder contributes to hepatotoxicity in juvenile common carp
- Author:
- Jingbo Liu; Chenyu Dong; Zhenzhen Zhai; Liang Tang; Lin Wang
- Source:
- Environmental pollution 2021 v.269 pp. 116186
- ISSN:
- 0269-7491
- Subject:
- lipid metabolism disorders, etc ; Cyprinus carpio; biomarkers; blood serum; cytokines; fish; gene expression; glyphosate; hepatotoxicity; histopathology; inflammation; juveniles; lipids; liver; oxidative stress; pollution; public health; Show all 17 Subjects
- Abstract:
- ... d, 30 d, and 45 d to analyze the assays. First, GLY-induced hepatic damage was confirmed by serum liver damage biomarker and hepatic histopathological analysis. Next, changes in oxidative stress biomarkers, gene expression levels of pro- and anti-inflammatory cytokines, and lipid metabolism-related parameters in collected samples were analyzed to clarify their roles in GLY-induced hepatic damage ...
- DOI:
- 10.1016/j.envpol.2020.116186
- https://doi.org/10.1016/j.envpol.2020.116186
- Author:
- Yingying Li; Xinyu Ji; Haonan Wu; Xiang Li; Huamin Zhang; Danli Tang
- Source:
- Journal of ethnopharmacology 2021 v.278 pp. 114207
- ISSN:
- 0378-8741
- Subject:
- lipid metabolism, etc ; Oriental traditional medicine; bile acids; biosynthesis; blood; databases; hyperlipidemia; intestinal microorganisms; intestines; metabolites; trimethylamine; Show all 11 Subjects
- Abstract:
- ... The gut microbiome plays an important role in advancing the process of host lipid metabolism directly or indirectly. Traditional Chinese medicine (TCM) can improve the intestinal environment by intervening with gut microbiota metabolites to potentially regulate lipid levels. However, the underlying mechanisms remain unclear. Therefore, we examined the current databases to search for studies ...
- DOI:
- 10.1016/j.jep.2021.114207
- https://doi.org/10.1016/j.jep.2021.114207
- Author:
- Ya Gao; Jia-Huan Hu; Xiao-Dong Liang; Jing Chen; Chun-Chun Liu; Ya-Yun Liu; Yan Cheng; Yun Young Go; Bin Zhou
- Source:
- Veterinary microbiology 2021 v.259 pp. 109152
- ISSN:
- 0378-1135
- Subject:
- lipid metabolism, etc ; Classical swine fever virus; Dengue virus; Hepatitis C virus; Japanese encephalitis virus; adsorption; antiviral properties; curcumin; dose response; drugs; fatty acids; genes; virus replication; viruses; Show all 14 Subjects
- Abstract:
- ... CSFV replication in a dose-dependent manner, but had no effect on virus adsorption and entry. Furthermore, the results showed that curcumin inhibited the expression of FASN, one of the key enzymes of fatty acid synthesis pathway, thereby, causing the reduction of the production of LDs upon infection. To this end, we detected transcription factor 6 (ATF6), the key factor of regulating lipid metabolism ...
- DOI:
- 10.1016/j.vetmic.2021.109152
- https://doi.org/10.1016/j.vetmic.2021.109152
- Author:
- Fuyuki Tokumasu; Eri H. Hayakawa; Junpei Fukumoto; Suzumi M. Tokuoka; Shinya Miyazaki
- Source:
- Parasitology international 2021 v.83 pp. 102369
- ISSN:
- 1383-5769
- Subject:
- lipid metabolism, etc ; Plasmodium falciparum; antimalarials; biophysics; cholesterol; erythrocytes; interior design; lipid composition; malaria; organelles; parasites; parasitism; parasitology; phospholipids; secretion; transportation; Show all 16 Subjects
- Abstract:
- ... Malaria parasites conceal themselves within host erythrocytes and establish a necessary logistics system through the three-membrane layered structures of these cells. To establish this system, lipid metabolism is needed for the de novo synthesis of lipids and the recycling of extracellular lipids and erythrocyte lipid components. Cholesterol supply depends on its uptake from the extracellular ...
- DOI:
- 10.1016/j.parint.2021.102369
- https://doi.org/10.1016/j.parint.2021.102369
- Author:
- Qingqing Hou; Shiming Zhang; Yuan Li; Huanjun Wang; Dan Zhang; Dongmei Qi; Yunlun Li; Haiqiang Jiang
- Source:
- Life sciences 2021 v.271 pp. 119145
- ISSN:
- 0024-3205
- Subject:
- lipid metabolism, etc ; circadian clocks; circadian rhythm; gene expression regulation; lipidomics; lipids; liquid chromatography; mass spectrometry; metabolites; Show all 9 Subjects
- Abstract:
- ... The aim of this study is to provide new insights on the association of lipid metabolites, circadian genes and lipid metabolism associated genes in spontaneously hypertensive rats.An untargeted lipidomics using ultrahigh performance liquid chromatography-mass spectrometry metabolomics was used to identify the differentially expressed lipid metabolites over 24 h in Spontaneously hypertensive rats ...
- DOI:
- 10.1016/j.lfs.2021.119145
- https://doi.org/10.1016/j.lfs.2021.119145
- Author:
- Yingying Liu; Yinghui Li; Yi Xiao; Yinglin Peng; Jianhua He; Chen Chen; Dingfu Xiao; Yulong Yin; Fengna Li
- Source:
- Animal nutrition 2021 v.7 no.2 pp. 421-429
- ISSN:
- 2405-6545
- Subject:
- lipid metabolism, etc ; acetyl-CoA carboxylase; animal nutrition; antioxidant activity; average daily gain; blood serum; corn; diet; fatty acid composition; finishing; gene expression; genes; glutathione; glutathione peroxidase; growth performance; leaves; lipid peroxidation; lipoprotein lipase; longissimus muscle; mitochondria; mulberries; muscle tissues; peroxisome proliferator-activated receptors; polyunsaturated fatty acids; sampling; soybean meal; swine; swine feeding; wheat bran; Show all 29 Subjects
- Abstract:
- ... This study evaluated the potential of mulberry leaf powder as an unconventional feed material for finishing pigs by assessing the growth performance, antioxidative properties, fatty acid profile, and lipid metabolism in 180 Xiangcun black pigs. Pigs with an initial body weight (BW) of 71.64 ± 1.46 kg were randomly assigned to 5 treatment groups, including the control diet and 4 experimental diets ...
- DOI:
- 10.1016/j.aninu.2020.08.005
- https://doi.org/10.1016/j.aninu.2020.08.005
- Author:
- Jiaqi Yang; Hexing Wang; Hongyi Du; Hongji Fang; Minghui Han; Linji Xu; Shuping Liu; Jianping Yi; Yue Chen; Qingwu Jiang; Gengsheng He
- Source:
- Chemosphere 2021 v.273 pp. 128566
- ISSN:
- 0045-6535
- Subject:
- lipid metabolism, etc ; blood serum; cholesterol; high density lipoprotein; low density lipoprotein; perfluorohexane sulfonic acid; perfluorononanoic acid; pregnancy; principal component analysis; triacylglycerols; China; Show all 11 Subjects
- Abstract:
- ... Laboratory and epidemiologic studies suggested that exposure to perfluoroalkyl substances (PFASs) could affect lipid metabolisms, but data remain limited for pregnant women. A total of 436 pregnant women were selected in Tangshan City, North China. Serum levels of 11 PFASs were determined in the early term of pregnancy. Four lipids (total cholesterol (TC), triglyceride (TG), high-density ...
- DOI:
- 10.1016/j.chemosphere.2020.128566
- https://doi.org/10.1016/j.chemosphere.2020.128566
- Author:
- Zhengfeng Ding
- Source:
- Journal of fish diseases 2021 v.44 no.3 pp. 305-313
- ISSN:
- 0140-7775
- Subject:
- lipid metabolism, etc ; Eriocheir sinensis; biomarkers; ceramides; color; crabs; diacylglycerols; energy; fatty acids; fish; hepatopancreas; histology; lipidomics; liquid chromatography; mass spectrometry; parasites; pathogenesis; pathogens; phosphatidylcholines; phosphatidylethanolamines; sphingomyelins; tissue tropism; triacylglycerols; Show all 23 Subjects
- Abstract:
- ... The microsporidia Hepatospora eriocheir has been identified as an emerging pathogenic agent in the commercial crab Eriocheir sinensis. Histology analysis indicated that hepatopancreas was a significant target for H. eriocheir infection. However, the functional consequences of such tissue tropism remain poorly studied. Considering that hepatopancreas was a centre for lipid metabolism and energy ...
- DOI:
- 10.1111/jfd.13284
- https://doi.org/10.1111/jfd.13284
- Author:
- Simona Mattioli; Gisella Paci; Filippo Fratini; Alessandro Dal Bosco; Tiziano Tuccinardi; Simone Mancini
- Source:
- Lebensmittel-Wissenschaft + [i.e. und] Technologie 2021 v.147 pp. 111644
- ISSN:
- 0023-6438
- Subject:
- lipid metabolism, etc ; Tenebrio molitor; antioxidants; breads; frass; microbial contamination; nutritive value; vitamin A; wastes; zeaxanthin; Show all 10 Subjects
- Abstract:
- ... The capability of some insects to be reared on by-products, waste and former foodstuff make them a very promising response to the increasing request of animals’ products. Mealworm larvae (Tenebrio molitor) are widely studied for feed and food purposes. In this study the effects of five diets were tested on the fatty acids (FA) profile, the lipid metabolism and the antioxidant molecules ...
- DOI:
- 10.1016/j.lwt.2021.111644
- https://doi.org/10.1016/j.lwt.2021.111644
- Author:
- Huan Wang; Bin Chen; Juan Tian; Zhaosheng Kong
- Source:
- Environmental microbiology 2021 v.23 no.4 pp. 1991-2003
- ISSN:
- 1462-2912
- Subject:
- lipid metabolism, etc ; Verticillium dahliae; biosynthesis; conidia; gene expression regulation; lint cotton; lipids; metabolome; metabolomics; microbiology; polyketides; secondary metabolites; sequence analysis; terpenoids; toxicity; ubiquitin-protein ligase; vascular wilt; Show all 17 Subjects
- Abstract:
- ... of the ∆VdBre1 strain was dramatically reduced. RNA‐seq revealed that a total of 1643 differentially expressed genes between the ∆VdBre1 strain and the wild type strain V592, among which genes related to lipid metabolism were significantly overrepresented. Remarkably, the volume of lipid droplets in the ∆VdBre1 conidia was shown to be smaller than that of wild‐type strains. Further metabolomics analysis ...
- DOI:
- 10.1111/1462-2920.15319
- https://doi.org/10.1111/1462-2920.15319
19. Roles of microRNAs in carbohydrate and lipid metabolism disorders and their therapeutic potential
- Author:
- Sujay Paul; Luis Alberto Bravo Vázquez; Samantha Pérez Uribe; Luis Aarón Manzanero Cárdenas; María Fernanda Ruíz Aguilar; Samik Chakraborty; Ashutosh Sharma
- Source:
- Biochimie 2021 v.187 pp. 83-93
- ISSN:
- 0300-9084
- Subject:
- lipid metabolism, etc ; carbohydrates; fatty liver; genes; homeostasis; hyperlipidemia; insulin resistance; lipids; mice; microRNA; non-coding RNA; noninsulin-dependent diabetes mellitus; nucleotides; obesity; therapeutics; Show all 15 Subjects
- Abstract:
- ... MicroRNAs (miRNAs) are small (∼21 nucleotides), endogenous, non-coding RNA molecules implicated in the post-transcriptional gene regulation performed through target mRNA cleavage or translational inhibition. In recent years, several investigations have demonstrated that miRNAs are involved in regulating both carbohydrate and lipid homeostasis in humans and other organisms. Moreover, it has been ob ...
- DOI:
- 10.1016/j.biochi.2021.05.015
- https://doi.org/10.1016/j.biochi.2021.05.015
- Author:
- Zhiqiang Li; Yeun-Po Chiang; Mulin He; Ke Zhang; Jiao Zheng; Weihua Wu; Jiajia Cai; Yong Chen; Guangzhi Chen; Yunqin Chen; Jibin Dong; Tilla S. Worgall; Xian-Cheng Jiang
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.5 pp. 158898
- ISSN:
- 1388-1981
- Subject:
- biosynthesis; blood lipids; ceramides; gene targeting; high fat diet; lipoprotein metabolism; liver; low density lipoprotein; metabolites; phosphatidylcholines; sphingomyelins; triacylglycerols; very low density lipoprotein
- Abstract:
- ... Sphingomyelin (SM) is one major phospholipids on lipoproteins. It is enriched on apolipoprotein B-containing particles, including very low-density lipoprotein (VLDL) and its catabolites, low-density lipoprotein (LDL). SM is synthesized by sphingomyelin synthase 1 and 2 (SMS1 and SMS2) which utilizes ceramide and phosphatidylcholine, as two substrates, to produce SM and diacylglyceride. SMS1 and SM ...
- DOI:
- 10.1016/j.bbalip.2021.158898
- https://doi.org/10.1016/j.bbalip.2021.158898