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1. Natural product puerarin activates Akt and ameliorates glucose and lipid metabolism dysfunction in hepatic cells

Author:
Shen, Yunbing; Yang, Shengnan; Hu, Xueyan; Zhang, Man; Ma, Xiaoyao; Wang, Zhihua; Hou, Yuanyuan; Bai, Gang
Source:
Journal of functional foods 2019 v.55 pp. 296-304
ISSN:
1756-4646
Subject:
lipid metabolism; lipid metabolism disorders,   etc   ; dietary supplements; glucose; insulin; insulin resistance; lipids; phosphorylation; proteins;     Show all 9 Subjects
Abstract:
... Puerarin, one of the major isoflavonoid compounds isolated from Gegen, is widely used to treat glucose and lipid disorders. Identifying the mechanism of puerarin’s action against lipid and glucose metabolism dysfunction is very important for its application and development. Based on the structure of puerarin, different chemical probes were synthesized to capture and identify puerarin’s protein tar ...
DOI:
10.1016/j.jff.2019.02.035

2. Probing in vitro digestion at oil–water interfaces

Author:
Maldonado-Valderrama, Julia
Source:
Current opinion in colloid & interface science 2019 v.39 pp. 51-60
ISSN:
1359-0294
Subject:
lipid metabolism,   etc   ; analytical methods; digestibility; emulsions; gastrointestinal system; microstructure;     Show all 6 Subjects
Abstract:
... Interfacial layers have been widely applied to study the formation and stability of emulsion-based systems. However, the application of isolated interfaces to address digestibility of emulsions is often limited because of the complexity of experimental methods and results. This review summarizes the latest developments in analytical methods and literature data on effects of digestion on interfacia ...
DOI:
10.1016/j.cocis.2019.01.004

3. RETRACTION: Alterations in lipid metabolism due to a protein-restricted diet in rats during gestation and/or lactation

Author:
Sosa-Larios, T. C.; Milliar-Garcia, A.; Reyes-Castro, L. A.; Morimoto, S.; Jaramillo-Flores, M. E.
Source:
Food & function 2018 v.9 no.2 pp. 1274
ISSN:
2042-650X
Subject:
lipid metabolism,   etc   ; diet; lactation; pregnancy; rats;     Show all 5 Subjects
Abstract:
... Retraction of ‘Alterations in lipid metabolism due to a protein-restricted diet in rats during gestation and/or lactation’ by T. C. Sosa-Larios, et al., Food Funct., 2017, DOI: 10.1039/c7fo01513e. ...
DOI:
10.1039/c7fo90045g

4. Increased GPR120 level is associated with gestational diabetes mellitus

Author:
He, Qingwen; Zhu, Shenglong; Lin, Mengyuan; Yang, Qin; Wei, Lengyun; Zhang, Jingwei; Jiang, Xuan; Zhu, Doudou; Lu, Xuyang; Chen, Yong Q.
Source:
Biochemical and biophysical research communications 2019 v.512 no.2 pp. 196-201
ISSN:
0006-291X
Subject:
lipid metabolism; lipid metabolism disorders,   etc   ; G-protein coupled receptors; G-proteins; free fatty acids; gestational diabetes; humans; lipid composition; lipids; mononuclear leukocytes; patients; pregnancy; pregnant women;     Show all 13 Subjects
Abstract:
... G-protein coupled receptor 120 (GPR120 or FFAR4) functions as a receptor for free fatty acids and plays a critical role in lipid metabolism. Studies have shown a close relationship between GDM and lipid metabolism disorders, whether GPR120 participates in the metabolic regulation of GDM remains unclear. In this study, 29 women with GDM and 33 normal pregnant women were enrolled. Lipid profiles wer ...
DOI:
10.1016/j.bbrc.2019.03.034

5. Gut‐derived short‐chain fatty acids: A friend or foe for hepatic lipid metabolism?

Author:
Chambers, E. S.
Source:
Nutrition bulletin 2019 v.44 no.2 pp. 154-159
ISSN:
1471-9827
Subject:
lipid metabolism,   etc   ; acetates; adults; lipid content; liver; propionic acid; short chain fatty acids; therapeutics;     Show all 8 Subjects
Abstract:
... This article describes how a British Nutrition Foundation Drummond Pump Priming Award was used to develop in vivo proof of concept for increasing colonic propionate as a therapeutic strategy to reduce liver fat in adults with non‐alcoholic fatty disease (NAFLD). An overview of how the gut‐derived short‐chain fatty acids propionate and acetate are taken up and metabolised by the liver is provided, ...
DOI:
10.1111/nbu.12377

6. De novo transcriptomic analysis of gonad of Strongylocentrotus nudus and gene discovery for biosynthesis of polyunsaturated fatty acids

Author:
Wei, Zhenlin; Liu, Xiaolin; Zhou, Zunchun; Xu, Junxiao
Source:
Genes & genomics 2019 v.41 no.5 pp. 583-597
ISSN:
1976-9571
Subject:
lipid metabolism,   etc   ; Strongylocentrotus nudus; biosynthesis; databases; enzymes; females; males; messenger RNA; polyunsaturated fatty acids; transcriptomics; unigenes;     Show all 11 Subjects
Abstract:
... BACKGROUND: Strongylocentrotus nudus is an important cultured sea urchin species in north China, because its gonad is rich in unsaturated fatty acids, particularly long polyunsaturated fatty acids (LC-PUFAs). These PUFAs play pleiotropic and crucial roles in a wide range of biological process. OBJECTIVE: However, the genes contributing to biosynthesis PUFAs have not been elucidated yet, and the mo ...
DOI:
10.1007/s13258-019-00799-6

7. Oat fiber inhibits atherosclerotic progression through improving lipid metabolism in ApoE−/− mice

Author:
Han, Shufen; Zhang, Ru; Gao, Hui; Yang, Jing; Zhang, Weiguo; Qin, Liqiang
Source:
Journal of functional foods 2019 v.56 pp. 14-20
ISSN:
1756-4646
Subject:
lipid metabolism,   etc   ; atherosclerosis; blood serum; cholesterol; death; high fat diet; intestinal absorption; mice; oats; protective effect;     Show all 10 Subjects
Abstract:
... Cardiovascular diseases caused by atherosclerosis have become one of the leading cause of death. The aim of the present study was to explore how oat fiber regulated lipid metabolism and to elucidate its anti-atherosclerotic potential in ApoE−/− mice. Animals were daily fed a high-fat diet without or with 0.8% oat fiber for 18 weeks. Both serum total cholesterol and low-density cholesterol levels d ...
DOI:
10.1016/j.jff.2019.02.046

8. ALDH2 deficiency inhibits Ox-LDL induced foam cell formation via suppressing CD36 expression

Author:
Wei, Shujian; Zhang, Luetao; Bailu wang,; Zhao, Yu; Dong, Qianqian; Pan, Chang; Li, Chuanbao; He, Dayu; Yuan, Qiuhuan; Xu, Feng; Chen, Yuguo
Source:
Biochemical and biophysical research communications 2019 v.512 no.1 pp. 41-48
ISSN:
0006-291X
Subject:
lipid metabolism,   etc   ; aldehyde dehydrogenase; aldehydes; atherosclerosis; coronary artery disease; foam cells; low density lipoprotein; mice; oxidation;     Show all 9 Subjects
Abstract:
... Foam cell formation plays an important role in the initiation and progression of atherosclerosis. Aldehyde dehydrogenase 2 (ALDH2), a key enzyme for aldehyde metabolism, is associated with coronary artery disease and affects atherosclerotic plaque vulnerability. However, the role of ALDH2 in foam cell formation remains unclear. Using peritoneal macrophages from ALDH2-deficient and control mice, we ...
DOI:
10.1016/j.bbrc.2019.02.012

9. HDAC6 regulates lipid droplet turnover in response to nutrient deprivation via p62-mediated selective autophagy

Author:
Yan, Yan; Wang, Hao; Wei, Chuanxian; Xiang, Yuanhang; Liang, Xuehong; Phang, Chung-Weng; Jiao, Renjie
Source:
Journal of genetics and genomics 2019 v.46 no.4 pp. 221-229
ISSN:
1673-8527
Subject:
lipid metabolism,   etc   ; Drosophila; autophagy; droplets; histone deacetylase; lipids; organelles; protein aggregates; starvation;     Show all 9 Subjects
Abstract:
... Autophagy has been evolved as one of the adaptive cellular processes in response to stresses such as nutrient deprivation. Various cellular cargos such as damaged organelles and protein aggregates can be selectively degraded through autophagy. Recently, the lipid storage organelle, lipid droplet (LD), has been reported to be the cargo of starvation-induced autophagy. However, it remains largely un ...
DOI:
10.1016/j.jgg.2019.03.008

10. Microarray analysis of gene expression of Atlantic cod from different Baltic Sea regions: Adaptation to salinity

Author:
Malachowicz, Magdalena; Wenne, Roman
Source:
Marine genomics 2019
ISSN:
1874-7787
Subject:
lipid metabolism,   etc   ; Gadus morhua; cell cycle; genes; immune system; microarray technology; oligonucleotides; salinity; Baltic Sea;     Show all 9 Subjects
Abstract:
... The Atlantic cod (Gadus morhua L.) is one of the most important species in the Baltic Sea with high ecological and economical value. To explore the differences in adaptation to salinity between Baltic cod from different regions, western (Kiel Bight) and eastern (Gdańsk Bay) samples were analyzed through oligonucleotide microarray. The results showed that a total of 1043 genes were differently expr ...
DOI:
10.1016/j.margen.2019.04.006

11. Altered lipoprotein profiles in cats with hepatic lipidosis

Author:
Minamoto, Tomomi; Walzem, Rosemary L; Hamilton, Alexandra J; Hill, Steve L; Payne, Harold R; Lidbury, Jonathan A; Suchodolski, Jan S; Steiner, Jörg M
Source:
Journal of feline medicine and surgery 2019 v.21 no.4 pp. 363-372
ISSN:
1532-2750
Subject:
lipid metabolism,   etc   ; blood serum; cats; chemistry; cholesterol; high density lipoprotein; low density lipoprotein; triacylglycerols;     Show all 8 Subjects
Abstract:
... The aim of this study was to assess serum lipoprotein profiles using rapid single-spin continuous lipoprotein density profiling (CLPDP) in healthy control cats and cats with hepatic lipidosis (HL). Analysis of serum lipoprotein profiles using the CLPDP was performed in 23 cats with HL and 20 healthy control cats. The area under the curve for each lipoprotein fraction, triglyceride (TG)-rich lipopr ...
DOI:
10.1177/1098612X18780060

12. Comparison of RNA Editing Activity of APOBEC1-A1CF and APOBEC1-RBM47 Complexes Reconstituted in HEK293T Cells

Author:
Wolfe, Aaron D.; Arnold, Don B.; Chen, Xiaojiang S.
Source:
Journal of molecular biology 2019 v.431 no.7 pp. 1506-1517
ISSN:
0022-2836
Subject:
lipid metabolism,   etc   ; RNA; RNA editing; cell lines; cytosine deaminase; fluorescence; gene expression; genes; humans; mice;     Show all 10 Subjects
Abstract:
... RNA editing is an important form of regulating gene expression and activity. APOBEC1 cytosine deaminase was initially characterized as pairing with a cofactor, A1CF, to form an active RNA editing complex that specifically targets APOB RNA in regulating lipid metabolism. Recent studies revealed that APOBEC1 may be involved in editing other potential RNA targets in a tissue-specific manner, and anot ...
DOI:
10.1016/j.jmb.2019.02.025

13. Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism

Author:
Cheng, Xiawei; Ma, Xiuling; Zhu, Qi; Song, Dandan; Ding, Xianming; Li, Lin; Jiang, Xiao; Wang, Xinyi; Tian, Rui; Su, Hua; Shen, Zhirong; Chen, She; Liu, Ting; Gong, Weihua; Liu, Wei; Sun, Qiming
Source:
Molecular cell 2019 v.73 no.4 pp. 788-802.e7
ISSN:
1097-2765
Subject:
lipid metabolism,   etc   ; acetylation; autophagy; dephosphorylation; droplets; glycogen; homeostasis; lipids; liver; liver cirrhosis; mice;     Show all 11 Subjects
Abstract:
... mTORC1 and GSK3 play critical roles in early stages of (macro)autophagy, but how they regulate late steps of autophagy remains poorly understood. Here we show that mTORC1 and GSK3-TIP60 signaling converge to modulate autophagosome maturation through Pacer, an autophagy regulator that was identified in our recent study. Hepatocyte-specific Pacer knockout in mice results in impaired autophagy flux, ...
DOI:
10.1016/j.molcel.2018.12.017

14. Catalytic behavior of pancreatic lipase in crowded medium for hydrolysis of medium-chain and long-chain lipid: An isothermal titration calorimetry study

Author:
Zhang, Yan; Luo, Xing-An; Zhu, Li-Juan; Wang, Shen-Zhi; Jia, Ming-Qiang; Chen, Zhong-Xiu
Source:
Thermochimica acta 2019 v.672 pp. 70-78
ISSN:
0040-6031
Subject:
lipid metabolism,   etc   ; calorimetry; catalytic activity; enzyme activity; enzyme kinetics; heat; hydrolysis; polysaccharides; swine; titration; triacylglycerol lipase;     Show all 11 Subjects
Abstract:
... Pancreatic lipase is an interfacial enzyme. The kinetic parameters of pancreatic lipase derived from heat release in crowded surroundings have not been reported. In this work, the effect of crowded medium on the catalytic activity of porcine pancreatic lipase (PPL) during lipid digestion was investigated by Isothermal Titration Calorimetry (ITC). The results showed that dietary polysaccharide Fico ...
DOI:
10.1016/j.tca.2018.12.015

15. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide

Author:
Wang, Wei; Xin, Jingxue; Yang, Xiao; Lam, Sin Man; Shui, Guanghou; Wang, Yong; Huang, Xun
Source:
Biochimica et biophysica acta 2019 v.1864 no.2 pp. 168-180
ISSN:
1388-1981
Subject:
lipid metabolism,   etc   ; Drosophila; RNA interference; biochemical pathways; genes; homeostasis; human cell lines; hydroxylation; triacylglycerols;     Show all 9 Subjects
Abstract:
... Lipid homeostasis is important for executing normal cellular functions and maintaining physiological conditions. The biophysical properties and intricate metabolic network of lipids underlie the coordinated regulation of different lipid species in lipid homeostasis. To reveal the homeostatic response among different lipids, we systematically knocked down 40 lipid metabolism genes in Drosophila S2 ...
DOI:
10.1016/j.bbalip.2018.11.010

16. Lipid storage and lipophagy regulates ferroptosis

Author:
Bai, Yuansong; Meng, Lingjun; Han, Leng; Jia, Yuanyuan; Zhao, Yanan; Gao, Huan; Kang, Rui; Wang, Xiaofeng; Tang, Daolin; Dai, Enyong
Source:
Biochemical and biophysical research communications 2019 v.508 no.4 pp. 997-1003
ISSN:
0006-291X
Subject:
lipid metabolism,   etc   ; antioxidants; cell death; droplets; hepatocytes; humans; inflammation; lipid peroxidation; lipids; mice;     Show all 10 Subjects
Abstract:
... The synthesis, storage, and degradation of lipids are highly regulated processes. Impaired lipid metabolism is implicated in inflammation and cell death. Although ferroptosis is a recently described form of regulated cell death driven by lipid peroxidation, the impact of lipid droplets on ferroptosis remains unidentified. Here, we demonstrate that lipophagy, the autophagic degradation of intracell ...
DOI:
10.1016/j.bbrc.2018.12.039

17. Each liver X receptor (LXR) type has a different purpose in different situations

Author:
Yonezawa, Sei; Abe, Mizuho; Kawasaki, Yasushi; Natori, Yasuhiro; Sugiyama, Akinori
Source:
Biochemical and biophysical research communications 2019 v.508 no.1 pp. 92-96
ISSN:
0006-291X
Subject:
lipid metabolism,   etc   ; epithelial cells; excretion; gene expression regulation; genes; kidneys; lipids; liver; models; nephrosis; receptors;     Show all 11 Subjects
Abstract:
... LXRs, which are nuclear receptors, have 2 isoforms—LXRα and LXRβ. Generally, LXRα is expressed in the liver, kidney, and a limited number of other organs, whereas LXRβ is thought to be expressed ubiquitously. Nevertheless, no clear consensus has been reached on the role of each in kidney lipid metabolism.Many researchers have reported that lipids accumulate in renal tubular epithelial cells during ...
DOI:
10.1016/j.bbrc.2018.11.076

18. Therapeutic targeting of lipid synthesis metabolism for selective elimination of cancer stem cells

Author:
Kim, Woo-Young
Source:
Archives of pharmacal research 2019 v.42 no.1 pp. 25-39
ISSN:
0253-6269
Subject:
lipid metabolism,   etc   ; adenosine triphosphate; biosynthesis; cholesterol; metastasis; monounsaturated fatty acids; neoplasm cells; neoplasms; stem cells; therapeutics;     Show all 10 Subjects
Abstract:
... Cancer stem cells (CSCs) are believed to have an essential role in tumor resistance and metastasis; however, no therapeutic strategy for the selective elimination of CSCs has been established. Recently, several studies have shown that the metabolic regulation for ATP synthesis and biological building block generation in CSCs are different from that in bulk cancer cells and rather similar to that i ...
DOI:
10.1007/s12272-018-1098-z

19. Enhancing Therapy: It’s about Time

Author:
Brown, Myles
Source:
Cell 2018 v.174 no.4 pp. 771-772
ISSN:
0092-8674
Subject:
lipid metabolism,   etc   ; diet; diurnal variation; drugs; genes; obesity; therapeutics;     Show all 7 Subjects
Abstract:
... How diet and obesity impact diurnal changes in physiology remains unclear. In this issue of Cell, Guan et al. report that diet-induced obesity modulates the activity of circadian gene enhancers including those regulating lipid metabolism and show that the efficacy of lipid-lowering drugs depends on the time of administration. ...
DOI:
10.1016/j.cell.2018.07.037

20. Lipid Droplet Metabolism during Dengue Virus Infection

Author:
Randall, Glenn
Source:
Trends in microbiology 2018 v.26 no.8 pp. 640-642
ISSN:
0966-842X
Subject:
lipid metabolism,   etc   ; Dengue virus; autophagy; dengue; droplets; lipids;     Show all 6 Subjects
Abstract:
... Dengue virus (DENV) induces a proviral selective autophagy targeting lipid droplets, termed lipophagy, that stimulates lipid metabolism. Zhang et al. gained mechanistic insight into this process, demonstrating that DENV NS4A/B binds unmodified AUP1 and promotes its translocation from lipid droplets to autophagosomes to drive the induction of lipophagy. ...
DOI:
10.1016/j.tim.2018.05.010