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1. Maximizing two-dimensional liquid chromatography peak capacity for the separation of complex industrial samples

Author:
Zhu, Koudi; Pursch, Matthias; Eeltink, Sebastiaan; Desmet, Gert
Source:
Journal of chromatography 2020 v.1609 pp. 460457
ISSN:
0021-9673
Subject:
liquid chromatography,   etc   ; industry; polymers;     Show all 3 Subjects
Abstract:
... We report on a study on the use of 2D-LC in industry wherein we maximized the peak capacity by serially coupling up to six 15 cm long columns in the 1st dimension. For the considered aromatic amine oligomer sample, the combination of reverse phase pentafluorophenyl column providing selectivity based on π–π interaction in the 1st and a more retaining reverse phase polymeric C18 column in the 2nd di ...
DOI:
10.1016/j.chroma.2019.460457

2. Liquid chromatography above 20,000 PSI

Author:
Sorensen, Matthew J.; Anderson, Brady G.; Kennedy, Robert T.
Source:
Trends in analytical chemistry 2020 v.124 pp. 115810
ISSN:
0165-9936
Subject:
high performance liquid chromatography; ultra-performance liquid chromatography,   etc   ; instrumentation;     Show all 3 Subject
Abstract:
... Continued improvements in HPLC have led to faster and more efficient separations than previously possible. One important aspect of these improvements has been the increase in instrument operating pressure and the advent of ultrahigh pressure LC (UHPLC). Commercial instrumentation is now capable of up to ~20 kpsi, allowing fast and efficient separations with 5–15 cm columns packed with sub-2 μm par ...
DOI:
10.1016/j.trac.2020.115810
PubMed:
32382203
PubMed Central:
PMC7204529

3. Application of two‐dimensional liquid chromatography in the separation of traditional Chinese medicine

Author:
Zhou, Weijia; Liu, Yanming; Wang, Jixia; Guo, Zhimou; Shen, Aijin; Liu, Yanfang; Liang, Xinmiao
Source:
Journal of separation science 2020 v.43 no.1 pp. 87-104
ISSN:
1615-9306
Subject:
comprehensive two-dimensional liquid chromatography; liquid chromatography,   etc   ; Oriental traditional medicine;     Show all 3 Subject
Abstract:
... Traditional Chinese medicines have been widely used to prevent and cure diseases for thousands of years. For the purpose of better understanding the extremely complicated traditional Chinese medicines, powerful separation techniques are essential. Two‐dimensional liquid chromatography has been proven to be more powerful for the separation of complex traditional Chinese medicines due to its enhance ...
DOI:
10.1002/jssc.201900765

4. Characterization of triacontyl (C-30) liquid chromatographic columns

Author:
Sander, Lane C.; Rimmer, Catherine A.; Wilson, Walter B.
Source:
Journal of chromatography 2020 v.1614 pp. 460732
ISSN:
0021-9673
Subject:
liquid chromatography,   etc   ; isomers; lutein; temperature;     Show all 4 Subjects
Abstract:
... Differences in the characteristics of seventeen commercial C-30 liquid chromatographic columns were studied for the separation of carotenoid isomers. A mixture consisting of nine xanthophyll and hydrocarbon carotenoids were separated under conditions carefully chosen to reveal changes in selectivity. The influence of the mobile phase composition, column temperature, and mobile phase flow rate were ...
DOI:
10.1016/j.chroma.2019.460732

5. Optimizing design and employing permeability differences to achieve flow confinement in devices for spatial multidimensional liquid chromatography

Author:
Adamopoulou, Theodora; Deridder, Sander; Bos, Tijmen S.; Nawada, Suhas; Desmet, Gert; Schoenmakers, Peter J.
Source:
Journal of chromatography 2020 v.1612 pp. 460665
ISSN:
0021-9673
Subject:
liquid chromatography,   etc   ; fluid mechanics; permeability;     Show all 3 Subjects
Abstract:
... In spatial multi-dimensional liquid chromatography (LC) devices the flow of each dimension has to remain in the corresponding region, otherwise the separation efficiency is undermined. Adequate flow-confinement measures are necessary. Here, the use of permeability differences across different compartments of spatial two-dimensional (2D) and three-dimensional (3D) LC devices as a method to guide fl ...
DOI:
10.1016/j.chroma.2019.460665

6. Strategies for Drawing Quantitative Conclusions from Nontargeted Liquid Chromatography–High-Resolution Mass Spectrometry Analysis

Author:
Kruve, Anneli
Source:
Analytical chemistry 2020 v.92 no.7 pp. 4691-4699
ISSN:
1520-6882
Subject:
liquid chromatography,   etc   ; ionization; mass spectrometry; radiolabeling;     Show all 4 Subjects
Abstract:
... This Feature aims at giving an overview of different possibilities for quantitatively comparing the results obtained from LC−HRMS-based nontargeted analysis. More specifically, quantification via structurally similar internal standards, different isotope labeling strategies, radiolabeling, and predicted ionization efficiencies are reviewed. ...
DOI:
10.1021/acs.analchem.9b03481

7. Improving peak capacities over 100 in less than 60 seconds: operating above normal peak capacity limits with signal processing

Author:
Hellinghausen, Garrett; Wahab, M. Farooq; Armstrong, Daniel W.
Source:
Analytical and bioanalytical chemistry 2020 v.412 no.8 pp. 1925-1932
ISSN:
1618-2642
Subject:
liquid chromatography,   etc   ; information processing; instrumentation; mathematics; prediction;     Show all 5 Subjects
Abstract:
... A primary focus in liquid chromatography analysis of complex samples is high peak capacity separations. Using advanced instrumentation and optimal small, high-efficiency columns, complex multicomponent mixtures can now be analyzed in relatively short times. Despite these advances, chromatographic peak overlap is still observed. Recently, attention has shifted from improvements in chromatographic e ...
DOI:
10.1007/s00216-020-02444-8

8. Sources of overestimation in the analysis of acrylamide-in coffee by liquid chromatography mass spectrometry

Author:
Desmarchelier, Aurélien; Hamel, Jonas; Delatour, Thierry
Source:
Journal of chromatography 2020 v.1610 pp. 460566
ISSN:
0021-9673
Subject:
liquid chromatography,   etc   ; acrylamides; ions; tandem mass spectrometry;     Show all 4 Subjects
Abstract:
... Analysis of acrylamide in coffee by liquid chromatography-tandem mass spectrometry (LC-MS/MS) is prone to interferences. According to our study, unknown background ions can entail an overestimation by up to 40% in case of coelution with acrylamide. In order to develop a precise and accurate quantification method for acrylamide, identification and removal of these interfering ions is requested. We ...
DOI:
10.1016/j.chroma.2019.460566

9. Robustness assessment in computer-assisted liquid chromatography procedures based on desirability functions

Author:
Triñanes, S.; Rodriguez-Mier, P.; Cobas, C.; Sánchez, E.; Phan-Tan-Luu, R.; Cela, R.
Source:
Journal of chromatography 2020 v.1609 pp. 460439
ISSN:
0021-9673
Subject:
liquid chromatography,   etc   ; chemical analysis; computer analysis; models;     Show all 4 Subjects
Abstract:
... A novel approach based on the use of desirability functions is presented for the robustness assessment of liquid chromatographic separations as derived from computer-assisted methods development processes. The approach is based on generally accepted hypothesis that a robust separation procedure will be inert to small random variations of the operational variables, typically encountered in the day- ...
DOI:
10.1016/j.chroma.2019.460439

10. Separation and quantification of imidazoles in atmospheric particles using LC–Orbitrap‐MS

Author:
Teich, Monique; Schmidtpott, Mechthild; van Pinxteren, Dominik; Chen, Jianmin; Herrmann, Hartmut
Source:
Journal of separation science 2020 v.43 no.3 pp. 577-589
ISSN:
1615-9306
Subject:
high performance liquid chromatography; ultra-performance liquid chromatography,   etc   ; aerosols; detection limit; imidazoles; organic carbon; spectrometers;     Show all 7 Subjects
Abstract:
... A method using ultra‐high performance liquid chromatography coupled to a high resolution Orbitrap mass spectrometer was developed to identify and quantify imidazoles in aqueous extracts of aerosol particles. The aqueous particle extract was used without further enrichment or sample clean‐up. Five columns were tested for efficient separation of ten imidazoles and the Acquity HSS T3 column was chose ...
DOI:
10.1002/jssc.201900689

11. Ultra high performance liquid chromatography method development for separation of omeprazole and related substances on core‐shell columns using a Quality by Design approach

Author:
Johansson, Emma; Karlsson, Anders; Ludvigsson, Jufang Wu
Source:
Journal of separation science 2020 v.43 no.4 pp. 696-707
ISSN:
1615-9306
Subject:
high performance liquid chromatography; ultra-performance liquid chromatography,   etc   ; acetonitrile; pH; phosphates; temperature;     Show all 6 Subjects
Abstract:
... An updated and improved method for analysis of omeprazole/esomeprazole and related substances on core‐shell columns was developed using Fusion LC Method Development™. The method was optimized with respect to column type, column temperature, mobile phase pH level, and gradient time. Four different core‐shell columns were examined to develop a method suitable for both high performance‐ and ultra‐hig ...
DOI:
10.1002/jssc.201900726

12. Ultra-High-Performance Reversed-Phase Liquid Chromatography Hyphenated with ESI-Q-TOF-MS for the Analysis of Unmodified and Antisense Oligonucleotides

Author:
Studzińska, Sylwia; Nuckowski, Łukasz; Kilanowska, Anna
Source:
Chromatographia 2020 v.83 no.3 pp. 349-360
ISSN:
0009-5893
Subject:
high performance liquid chromatography; reversed-phase liquid chromatography; ultra-performance liquid chromatography,   etc   ; aromatic compounds; ion pair chromatography; mass spectrometry; oligonucleotides; pH; salt concentration; salt content; salts;     Show all 11 Subjects
Abstract:
... The reversed-phase ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry method was developed during the study and successfully applied to separation and analysis of unmodified and antisense oligonucleotides. It was shown that oligonucleotide separation strongly depends on the stationary phase type. The type, pH and salt content in the mobile phase influence also ...
DOI:
10.1007/s10337-019-03844-4

13. Apparent efficiency of serially coupled columns in gradient elution liquid chromatography: Extension to the combination of any column formats

Author:
Codesido, Santiago; Rudaz, Serge; Guillarme, Davy; Horváth, Krisztián; Fekete, Szabolcs
Source:
Journal of chromatography 2019 v.1588 pp. 159-162
ISSN:
0021-9673
Subject:
liquid chromatography,   etc   ; equations; models;     Show all 3 Subjects
Abstract:
... It was shown earlier that in serially coupled column systems, not only retention (selectivity) but peak width as well can change and the apparent peak width depends on the order of the columns. A generic equation has been developed to describe the apparent efficiency of serially coupled columns in gradient elution liquid chromatography mode. In a previous work, the theoretical basis for a two-colu ...
DOI:
10.1016/j.chroma.2018.12.037

14. Mechanistic studies of inhibition on acrolein by myricetin

Author:
Zhang, Dingmin; Jiang, Xiaoyun; Xiao, Liubang; Lu, Yongling; Sang, Shengmin; Lv, Lishuang; Dong, Wenjiang
Source:
Food chemistry 2020 v.323 pp. 126788
ISSN:
0308-8146
Subject:
liquid chromatography,   etc   ; acrolein; cookies; kaempferol; mass spectrometry; myricetin; quercetin; toxicity;     Show all 8 Subjects
Abstract:
... Acrolein (ACR) is an unsaturated aldehyde with high activity and toxicity and is produced in vivo and in food. This study investigated the impact of B-ring structure on the trapping of ACR by flavonols and the trapping mechanism and efficacy of ACR by myricetin. Galangin, kaempferol, quercetin, and myricetin, which possess the same A- and C-ring but different numbers of –OH groups on the B-ring, w ...
DOI:
10.1016/j.foodchem.2020.126788

15. Miniaturization of liquid chromatography coupled to mass spectrometry.: 2. Achievements on modern instrumentation for miniaturized liquid chromatography coupled to mass spectrometry

Author:
Vargas Medina, Deyber Arley; Maciel, Edvaldo Vasconcelos Soares; de Toffoli, Ana Lúcia; Lanças, Fernando Mauro
Source:
Trends in analytical chemistry 2020 v.128 pp. 115910
ISSN:
0165-9936
Subject:
liquid chromatography,   etc   ; atmospheric pressure; instrumentation; ionization; mass spectrometry;     Show all 5 Subjects
Abstract:
... Capillary and nano liquid chromatography coupled to mass spectrometry has recently become one of the primary analytical techniques in many science areas of maior interest, including omics, food security, environmental surveillance, biomedicine, among others. This interest relays on their economical, environmental and analytical advantages, such as low volumes of reagents and sample requirement, ga ...
DOI:
10.1016/j.trac.2020.115910

16. Pretreatment and non-specific binding in ultrafiltration device: Impact on protease inhibitor quantification

Author:
Castro, Thales Nascimento e; Costa, Edlaine Rijo; Gonçalves, José Carlos Saraiva; Estrela, Rita de Cassia Elias
Source:
Journal of chromatography 2020 v.1146 pp. 122127
ISSN:
1570-0232
Subject:
liquid chromatography,   etc   ; drugs; enzymes; mass spectrometry; polysorbates; proteinase inhibitors; ultrafiltration;     Show all 7 Subjects
Abstract:
... Ultrafiltration (UF) is used to separate unbound drugs; however, non-specific binding (NSB) may be a limiting factor of this technique. Pretreatment of UF devices has been suggested to reduce NSB. Therefore, the pretreatment methodologies for UF devices were evaluated in order to test their effectiveness in reducing NSB of protease inhibitors (PIs).Two PIs (lopinavir-LPV and ritonavir-RTV) were te ...
DOI:
10.1016/j.jchromb.2020.122127

17. Comprehensive two-dimensional liquid chromatography as a powerful tool for the analysis of food and food products

Author:
Cacciola, Francesco; Rigano, Francesca; Dugo, Paola; Mondello, Luigi
Source:
Trends in analytical chemistry 2020 v.127 pp. 115894
ISSN:
0165-9936
Subject:
comprehensive two-dimensional liquid chromatography,   etc   ; carotenoids; foods; lipids; polyphenols;     Show all 5 Subjects
Abstract:
... Comprehensive two-dimensional liquid chromatography represents a valuable and powerful tool for the analysis of very complex samples. This review article illustrates how the coupling of two single LC “orthogonal” separations can be of valid aid for ensuring a deep chemical investigations of foods and food products. Specifically, in the first part, considerations about method optimization and novel ...
DOI:
10.1016/j.trac.2020.115894

18. Cr speciation in foodstuffs, biological and environmental samples: Methodological approaches and analytical challenges – A critical review

Author:
Milačič, Radmila; Ščančar, Janez
Source:
Trends in analytical chemistry 2020 v.127 pp. 115888
ISSN:
0165-9936
Subject:
high performance liquid chromatography,   etc   ; atomic absorption spectrometry; chromium; foods;     Show all 4 Subjects
Abstract:
... In studies of impact of Cr on the environment and living organisms, speciation analysis plays a crucial role. To obtain reliable data on Cr speciation it is important to preserve species integrity during all steps of the analytical procedure. It is also crucial that for each sample matrix an appropriate speciation technique is applied. Non-chromatographic techniques were frequently applied for spe ...
DOI:
10.1016/j.trac.2020.115888

19. Simultaneous enantioseparation of nonsteroidal anti-inflammatory drugs by a one-dimensional liquid chromatography technique using a dynamically coated chiral porous silicon pillar array column

Author:
Naghdi, Elahe; Fakhari, Ali Reza; Baca, Martyna; De Malsche, Wim
Source:
Journal of chromatography 2020 v.1615 pp. 460752
ISSN:
0021-9673
Subject:
liquid chromatography,   etc   ; coatings; enantiomers; nonsteroidal anti-inflammatory agents; silicon;     Show all 5 Subjects
Abstract:
... The preparation of a highly efficient chiral liquid chromatography (LC) column is explored by dynamically coating a reversed-phase porous silicon pillar array column with hydroxypropyl-β-cyclodextrin (Hp-β-CD) as the chiral selector. Analyte mixtures composed of non-steroidal anti-inflammatory drugs were tested to reveal the enantioseparation potential of the column. The mechanism of chiral discri ...
DOI:
10.1016/j.chroma.2019.460752

20. Development and Validation of LC-MS/MS for Analyzing Potential Genotoxic Impurities in Pantoprazole Starting Materials

Author:
Chen, Yuyuan; Wu, Song; Yang, Qingyun
Source:
Journal of Analytical Methods in Chemistry (Online) 2020 v.2020
ISSN:
2090-8873
Subject:
liquid chromatography,   etc   ; guidelines; mutagens; quantitative analysis; tandem mass spectrometry; toxicology;     Show all 6 Subjects
Abstract:
... Pantoprazole sodium (PPZS) is a selective proton pump inhibitor used in the prevention and treatment of gastric acid-related diseases. Six potentially genotoxic impurities (PGIs) are involved in 5-difluoromethoxy-2-mercapto-1H-benzimidazole (DMBZ), which is the starting material of PPZS. To date, no suitable method has yet been developed for PGI separation and quantification at the threshold of to ...
DOI:
10.1155/2020/6597363
PubMed:
32211210
PubMed Central:
PMC7085375