U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Subject "live vaccines" Remove constraint Subject: "live vaccines"
Start Over

Search

2,317  Search Results

« Previous | 1 - 20 of 2,317 |
Number of results to display per page

Search Results

1. Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine?

Author:
Hazel M. Dockrell; Egle Butkeviciute
Source:
Vaccine 2022 v.40 no.11 pp. 1525-1533
ISSN:
0264-410X
Subject:
live vaccines,   etc   ; BCG vaccine; immunogenicity; tuberculosis; vaccination;     Show all 5 Subjects
Abstract:
... The BCG vaccine will, in 2021, have been in use for 100 years. Much remains to be understood, including the reasons for its variable efficacy against pulmonary tuberculosis in adults. This review will discuss what has been learnt about the BCG vaccine in the last two decades, and whether this new information can be exploited to improve its efficacy, by enhancing its ability to induce either antige ...
DOI:
10.1016/j.vaccine.2021.01.068

2. Enhancing the performance of sterile filtration for viral vaccines and model nanoparticles using an appropriate prefilter

Author:
Neil Taylor; Wanli (Justin) Ma; Adam Kristopeit; Sheng-Ching Wang; Andrew L. Zydney
Source:
Journal of membrane science 2022 v.647 pp. 120264
ISSN:
0376-7388
Subject:
live vaccines,   etc   ; bioprocessing; filtration; porosity; viral vaccines;     Show all 5 Subjects
Abstract:
... Prefilters are widely used to enhance the performance of normal flow filtration steps in bioprocessing; however little is known about the potential benefits of prefiltration in the sterile filtration of viral vaccines and other large particle biotherapeutics. Sterile filtration experiments were performed with a live-attenuated viral vaccine and model nanoparticle suspension, both of which have a s ...
DOI:
10.1016/j.memsci.2022.120264

3. WHO working group meeting to amend WHO Recommendations to assure the quality, safety and efficacy of live attenuated yellow fever vaccines

Author:
Javier Martin; Alan David Thomas Barrett; Dianliang Lei; Philip Minor
Source:
Vaccine 2022 v.40 no.26 pp. 3490-3494
ISSN:
0264-410X
Subject:
live vaccines,   etc   ; clinical examination; immunogenicity; stakeholders; surveys; viruses; yellow fever;     Show all 7 Subjects
Abstract:
... The current WHO Recommendations to assure the quality, safety and efficacy of live attenuated yellow fever vaccines were adopted in 2010. This document recommends that vaccine virus master and working seed lots should be tested for viscerotropism, immunogenicity and neurovirulence in monkeys. A vaccine manufacturer has reported, recently, discrepancies on the clinical scoring of monkeys during ass ...
DOI:
10.1016/j.vaccine.2022.04.095

4. The inactivated infectious bronchitis virus (IBV) vaccine used as booster in layer hens influences the breadth of protection against challenge with IBV variants

Author:
J. J. (Sjaak) de Wit; Peter De Herdt; Jane K. A. Cook; Marianna Andreopoulou; Irene Jorna; H. C. (Rik) Koopman
Source:
Avian pathology 2022 v.51 no.3 pp. 244-256
ISSN:
1465-3338
Subject:
live vaccines,   etc   ; Infectious bronchitis virus; antigens; egg production; vaccination; Massachusetts;     Show all 6 Subjects
Abstract:
... To achieve long term protection of laying and breeding hens against aberrant egg production caused by infectious bronchitis virus (IBV), a vaccination programme incorporating both live-attenuated and inactivated IBV vaccines is required. High quality IBV vaccines of both types are widely available, but the number of IBV variants of global importance continues to increase and it is not possible to ...
DOI:
10.1080/03079457.2022.2040731

5. Development of a PCR-based dot blot assay for the detection of fowl adenovirus

Author:
Lidan Hou; Qi Su; Yawen Zhang; Dan Liu; Yaqing Mao; Peng Zhao
Source:
Poultry science 2022 v.101 no.1 pp. 101540
ISSN:
0032-5791
Subject:
live vaccines,   etc   ; Adenoviridae; chickens; polymerase chain reaction; serotypes; viruses; China;     Show all 7 Subjects
Abstract:
... Group-I Fowl adenovirus (FAdV) is still widespread in China's chicken farms, leading to huge economic losses. The traditional PCR method, which can detect all serotypes at the same time, is not sensitive enough to obtain accurate results, especially in some samples containing only a low titer of virus, such as contaminated live vaccine. In order to solve this problem, this study developed a dot bl ...
DOI:
10.1016/j.psj.2021.101540

6. Breakthrough Infections: A Challenge towards Measles Elimination?

Author:
Clara Fappani; Maria Gori; Marta Canuti; Mara Terraneo; Daniela Colzani; Elisabetta Tanzi; Antonella Amendola; Silvia Bianchi
Source:
Microorganisms 2022 v.10 no.8 pp. -
ISSN:
2076-2607
Subject:
live vaccines,   etc   ; antibodies; decline; humoral immunity; measles; risk; vaccination; virus transmission;     Show all 8 Subjects
Abstract:
... Measles is one of the most contagious diseases known to man. Despite the existence of a safe and effective live attenuated vaccine, measles can appear in vaccinated individuals. Paradoxically, breakthrough cases increase as vaccination coverage in the general population rises. In measles endemic areas, breakthrough cases represent less than 10% of total infections, while in areas with high vaccina ...
DOI:
10.3390/microorganisms10081567

7. Effectiveness of Live-Attenuated Genotype III Japanese Encephalitis Viral Vaccine against Circulating Genotype I Viruses in Swine

Author:
Yi-Chin Fan; Yi-Ying Chen; Jo-Mei Chen; Chienjin Huang; Mei Huang; Shyan-Song Chiou
Source:
Viruses 2022 v.14 no.1 pp. -
ISSN:
1999-4915
Subject:
live vaccines,   etc   ; encephalitis; fetal death; genotype; public health; viral vaccines; viruses;     Show all 7 Subjects
Abstract:
... Expansion of genotype I (GI) Japanese encephalitis viruses (JEV) has resulted in the replacement of the dominant genotype III (GIII) viruses, raising serious public health concerns for using GIII virus-derived vaccines to effectively control JEV epidemics. Therefore, this study used swine as the model to estimate the effectiveness of GIII live-attenuated vaccine against GI virus infection by compa ...
DOI:
10.3390/v14010114

8. A review on the recent advances and application of vaccines against fish pathogens in aquaculture

Author:
Haimanti Mondal; John Thomas
Source:
Aquaculture international 2022 v.30 no.4 pp. 1971-2000
ISSN:
0967-6120
Subject:
live vaccines,   etc   ; DNA; aquaculture; fish; mutants; probiotics; synthetic peptides; therapeutics; vaccine development;     Show all 9 Subjects
Abstract:
... Globally, aquaculture has faced serious economic problems due to bacterial, viral, and various other infectious diseases of different origins. Even though such diseases are being detected and simultaneously treated with several therapeutic and prophylactic methods, the broad-spectrum activity of vaccines plays a vital role as a preventive measure in aquaculture. However, treatments like use of ant ...
DOI:
10.1007/s10499-022-00884-w

9. Phenotypic and genetic characterization of a next generation live-attenuated yellow fever vaccine candidate

Author:
Raphael Esson; Emanuel Rodrigues De Sousa; Loic Benair; Nicolas Devard; Damien Soulet; Audrey Gillet; Isabelle Bassard; Stephanie Falque; Audrey Chareyre; Morgane Marmin; Yves Girerd-Chambaz; Carine Logvinoff; Martha Erika Navarro Sanchez
Source:
Vaccine 2022 v.40 no.38 pp. 5641-5650
ISSN:
0264-410X
Subject:
live vaccines,   etc   ; amino acids; genetic stability; phenotype; virulence; virus replication; yellow fever;     Show all 7 Subjects
Abstract:
... We assessed the genetic and phenotypic characteristics of a yellow fever vaccine candidate, which was cloned from a YF-VAX substrain selected for growth in Vero cells (vYF-247), during the manufacturing process from the master seed lot (MSL) and working seed lot (WSL) through to the drug substance (DS) stage. There were nine minor nucleotide variants observed from the MSL to the DS stage, of which ...
DOI:
10.1016/j.vaccine.2022.07.043

10. Infectious Bronchitis Coronavirus: Genome Evolution in Vaccinated and Non-Vaccinated SPF Chickens

Author:
Alexandre Flageul; Chantal Allée; Céline Courtillon; Véronique Béven; Hélène Quenault; Yannick Blanchard; Michel Amelot; David Courtois; Sjaak De Wit; Nicolas Eterradossi; Béatrice Grasland; Paul A. Brown
Source:
Viruses 2022 v.14 no.7 pp. -
ISSN:
1999-4915
Subject:
live vaccines,   etc   ; Infectious bronchitis virus; RNA; chicken industry; evolution; genome; infectious bronchitis; viruses;     Show all 8 Subjects
Abstract:
... Infectious Bronchitis virus (IBV) continues to cause significant economic losses for the chicken industry despite the use of many live IBV vaccines around the world. Several authors have suggested that vaccine-induced partial protection may contribute to the emergence of new IBV strains. In order to study this hypothesis, three passages of a challenge IBV were made in SPF chickens sham inoculated ...
DOI:
10.3390/v14071392

11. Comparison of susceptibility of different goat breeds to live attenuated goatpox vaccine

Author:
Mohammadreza Ghorani; Hossein Esmaeili
Source:
Small ruminant research 2022 v.212 pp. 106721
ISSN:
0921-4488
Subject:
live vaccines,   etc   ; Murcia-Granada; Saanen; biosecurity; enzootic diseases; goats; morbidity; mortality; research; vaccination;     Show all 10 Subjects
Abstract:
... Goatpox in small ruminants is the most acute pox disease in domestic animals, playing an important role in their health. Vaccination and biosecurity are the two main strategies to control the disease in countries where goatpox is enzootic. In this study, the susceptibility and reactions of three pure breeds (Saanen, Alpine, and Murcia-Granada) and two hybrid breeds (Saanen-Mahabadi and Alpine-Maha ...
DOI:
10.1016/j.smallrumres.2022.106721

12. Development of a farm-specific real-time quantitative RT-PCR assay for the detection and discrimination of wild-type porcine reproductive respiratory syndrome virus and the vaccine strain in a farm under eradication

Author:
Kinga Fornyos; István Szabó; Károly Lebhardt; Ádám Bálint
Source:
Acta veterinaria Hungarica 2022 pp. -
ISSN:
1588-2705
Subject:
live vaccines,   etc   ; Betaarterivirus suid 1; farms; immunization; porcine reproductive and respiratory syndrome; swine; viruses;     Show all 7 Subjects
Abstract:
... Porcine reproductive and respiratory syndrome (PRRS) is one of the most important diseases of swine causing severe economic losses worldwide, therefore intensive efforts are taken to eliminate PRRS virus (PRRSV) from infected herds for complete eradication. The most efficient, fastest but at the same time the most expensive eradication method is depopulation-repopulation. In order to reduce costs, ...
DOI:
10.1556/004.2022.00020

13. Long-term protective immunity to goatpox in goats after a single immunization with a live attenuated goatpox vaccine

Author:
Veerakyathappa Bhanuprakash; Madhusudan Hosamani; Gnanavel Venkatesan; Raj Kumar Singh
Source:
Archives of virology 2022 v.167 no.10 pp. 2035-2040
ISSN:
0304-8608
Subject:
live vaccines,   etc   ; blood serum; enzootic diseases; immunity; neutralization; neutralization tests; vaccination; virology; virulence; viruses;     Show all 10 Subjects
Abstract:
... In this study, the duration of immunity following a single-dose vaccination using an attenuated live goatpox vaccine (GTPV/Uttarkashi/1978 strain) was evaluated in goatpox-seronegative goats for 52 months. Long-term immunity was evaluated by clinical protection upon virulent virus challenge and serum neutralization assay applied to serum samples. The rise in the level of GTPV-specific antibodies w ...
DOI:
10.1007/s00705-022-05505-8

14. Two Bordetella bronchiseptica attenuated vaccine candidates confer protection against lethal challenge with B. Bronchiseptica and Pasteurella multocida toxin in mouse models

Author:
Yue Zhang; Lin Lin; Jie Yang; Qingjie Lv; Mixue Wang; Fei Wang; Xi Huang; Lin Hua; Xiangru Wang; Huanchun Chen; Brenda A. Wilson; Bin Wu; Zhong Peng
Source:
Vaccine 2022 v.40 no.27 pp. 3771-3780
ISSN:
0264-410X
Subject:
live vaccines,   etc   ; Bordetella bronchiseptica; Pasteurella multocida; chromosomes; genes; interleukin-10; mice; toxins; vaccination; virulence;     Show all 10 Subjects
Abstract:
... Dermonecrotic toxin (DNT) is an important bacterial virulence factor produced by the zoonotic pathogens Bordetella bronchiseptica and Pasteurella multocida. This study aims to explore the possibility of expressing different fragments of P. multocida toxin (PMT) in the chromosome of attenuated B. bronchiseptica to generate single-component mucosal vaccine candidates. To achieve this, a 954-bp fragm ...
DOI:
10.1016/j.vaccine.2022.05.021

15. Genetic Diversity Does Not Contribute to Attenuation of HeLa Passaged Wild-Type Yellow Fever Virus Strain French Viscerotropic Virus

Author:
Ashley E. Strother; Jill K. Thompson; Steven G. Widen; Alan D. T. Barrett
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
live vaccines,   etc   ; Yellow fever virus; amino acids; genetic variation; nucleotide sequences; viruses; yellow fever;     Show all 7 Subjects
Abstract:
... The disease yellow fever was prevented by two live attenuated vaccines, strains 17D and French neurotropic vaccine (FNV), derived by serial passage of wild-type (WT) strains Asibi and French Viscerotropic virus (FVV), respectively. Both 17D and FNV displayed decreased genetic diversity and resistance to the antiviral Ribavirin compared to their WT parental strains, which are thought to contribute ...
DOI:
10.3390/v14030527

16. International Nonproprietary Names (INN) for novel vaccine substances: A matter of safety

Author:
James S. Robertson; Ursula Loizides; Akinola Adisa; Ana López de la Rica Manjavacas; Vicente Rodilla; Colette Strnadova; Karin Weisser; Raffaella Balocco
Source:
Vaccine 2022 v.40 no.1 pp. 21-27
ISSN:
0264-410X
Subject:
live vaccines,   etc   ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; World Health Organization; viruses;     Show all 5 Subjects
Abstract:
... International Nonproprietary Names (INN) are assigned by the World Health Organization (WHO) to pharmaceutical substances to ensure global recognition by a unique name. INN facilitate safe prescribing through naming consistency, efficient communication and exchange of information, transnational access and pharmacovigilance of medicinal products. Traditional vaccines such as inactivated or live-att ...
DOI:
10.1016/j.vaccine.2021.11.054

17. Prevention and Control of Porcine Epidemic Diarrhea: The Development of Recombination-Resistant Live Attenuated Vaccines

Author:
Xiaoyu Niu; Qiuhong Wang
Source:
Viruses 2022 v.14 no.6 pp. -
ISSN:
1999-4915
Subject:
live vaccines,   etc   ; colostrum; diarrhea; immunity; milk; mortality; pork; pork industry; transcription (genetics); vaccination; virulence; viruses;     Show all 12 Subjects
Abstract:
... Porcine epidemic diarrhea (PED), causing up to 100% mortality in neonatal pigs, is a highly contagious enteric disease caused by PED virus (PEDV). The highly virulent genogroup 2 (G2) PEDV emerged in 2010 and has caused huge economic losses to the pork industry globally. It was first reported in the US in 2013, caused country-wide outbreaks, and posed tremendous hardship for many pork producers in ...
DOI:
10.3390/v14061317

18. HA and M2 sequences alter the replication of 2013–16 H1 live attenuated influenza vaccine infection in human nasal epithelial cell cultures

Author:
Laura M. Canaday; Jessica D. Resnick; Hsuan Liu; Harrison Powell; Alyssa M. McCoy; Dat Nguyen; Andrew Pekosz
Source:
Vaccine 2022 v.40 no.32 pp. 4544-4553
ISSN:
0264-410X
Subject:
live vaccines,   etc   ; RNA; chemokines; dogs; epithelial cells; humans; influenza vaccines; interferons; kidneys; mutation; nose; phenotype; viruses;     Show all 13 Subjects
Abstract:
... From 2013 to 2016, the H1N1 component of live, attenuated influenza vaccine (LAIV) performed very poorly in contrast to the inactivated influenza vaccine. We utilized a primary, differentiated human nasal epithelial cell (hNEC) culture system to assess the replication differences between isogenic LAIVs containing the HA segment from either A/Bolivia/559/2013 (rBol), which showed poor vaccine effic ...
DOI:
10.1016/j.vaccine.2022.05.088

19. Effective cross-protection of a lyophilized live gE/gI/TK-deleted pseudorabies virus (PRV) vaccine against classical and variant PRV challenges

Author:
Yuzhang Sun; Ling Zhao; Zhen F. Fu
Source:
Veterinary microbiology 2022 v.267 pp. 109387
ISSN:
0378-1135
Subject:
live vaccines,   etc   ; Aujeszky disease; Suid alphaherpesvirus 1; cross immunity; freeze drying; microbiology; pork industry; virulence; China;     Show all 9 Subjects
Abstract:
... Classical Bartha-K61 strains could not provide complete protection against the emerging highly virulent pseudorabies virus (PRV) variant strains, which has caused great economic losses to swine industry in China. In this study, a gE/gI/TK-deleted PRV vaccine strain based on a circulating PRV variant strain HeB12 was generated by serial passages in Vero cells and a lyophilized formulation was prepa ...
DOI:
10.1016/j.vetmic.2022.109387

20. Live attenuated vaccines, a favorable strategy to provide long-term immunity against protozoan diseases

Author:
Jose C. Solana; Javier Moreno; Salvador Iborra; Manuel Soto; Jose M. Requena
Source:
Trends in parasitology 2022 v.38 no.4 pp. 316-334
ISSN:
1471-4922
Subject:
live vaccines,   etc   ; Chagas disease; Protozoa; biosafety; clinical examination; immunity; irradiation; leishmaniasis; malaria; parasitology; sporozoites; sustainable development;     Show all 12 Subjects
Abstract:
... The control of diseases caused by protozoan parasites is one of the United Nations' Sustainable Development Goals. In recent years much research effort has gone into developing a new generation of live attenuated vaccines (LAVs) against malaria, Chagas disease and leishmaniasis. However, there is a bottleneck related to their biosafety, production, and distribution that slows downs further develop ...
DOI:
10.1016/j.pt.2021.11.004