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Jin-Ju Jeong; Hee Jin Park; Min Gi Cha; Eunju Park; Sung-Min Won; Raja Ganesan; Haripriya Gupta; Yoseph Asmelash Gebru; Satya Priya Sharma; Su Been Lee; Goo Hyun Kwon; Min Kyo Jeong; Byeong Hyun Min; Ji Ye Hyun; Jung A Eom; Sang Jun Yoon; Mi Ran Choi; Dong Joon Kim; Ki Tae Suk
liver; liver diseases, etc ; Lactobacillus; gastrointestinal system; probiotics; Show all 5 Subjects
Abstract:
... Over the past decade, scientific evidence for the properties, functions, and beneficial effects of probiotics for humans has continued to accumulate. Interest in the use of probiotics for humans has increased tremendously. Among various microorganisms, probiotics using bacteria have been widely studied and commercialized, and, among them, Lactobacillus is representative. This genus contains about ...
... Acute liver injury is a serious clinical syndrome with multiple causes and unclear pathological process. Here, CCl₄‐ and D‐galactosamine/lipopolysaccharide (D‐gal/LPS)‐induced acute liver injury was established to explore the cell death patterns and determine whether or not liver regeneration occurred. In CCl₄‐induced hepatic injury, three phases, including the early, progressive, and recovery pha ...
... Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition characterized from hypertriglyceridemia and hepatic fat accumulation, in the absence of alcohol intake. NAFLD starts as steatosis (NAFL), and the continued injury relative to the toxic fat induces inflammation, steatohepatitis (NASH), and HCC. One of the factors determining liver degeneration during the evolution of NAFLD is a ...
liver, etc ; Danio rerio; adults; bioaccumulation; brain; chemical analysis; flame retardants; histopathology; humans; pollution; progeny; toxicity; transcription (genetics); China; Show all 14 Subjects
Abstract:
... Many environmental contaminants could be transmitted from parents and generate impairments to their progeny. The 2,4,6-tribromophenol (TBP), a novel brominated flame retardant which has been frequently detected in various organisms, was supposed to be bioaccumulated and intergenerational transmitted in human beings. Previous studies revealed that TBP could disrupt thyroid endocrine system in zebra ...
... Baicalin is a flavonoid compound abundant in multiple edible and medicinal plants such as Scutellaria baicalensis Georgi. In this study, we provide evidence to support the fact that baicalin ameliorates alcohol-induced hepatic steatosis via regulating SREBP1c elicited PNPLA3 competitive binding to ATGL. Results showed that baicalin significantly attenuated the development of metabolic disorders an ...
fatty liver; liver, etc ; RNA; apoptosis; diet; hepatocytes; phosphorylation; protein content; Show all 8 Subjects
Abstract:
... Non-alcoholic fatty liver disease is one of the major health concerns in the World. The dietary free fatty acids (FFAs) affect the metabolic status of the hepatocytes by modulating cellular pathways. In this study, we showed that free fatty acids stimulate apoptosis by upregulating miR-181a-5p expression, which in turn targets XIAP and Bcl2. Huh7 cells were incubated with FFAs for 72 h and the exp ...
liver; liver regeneration, etc ; RNA; drugs; humans; metabolomics; multiomics; proteomics; reproduction; Show all 9 Subjects
Abstract:
... Liver modeling in disease via advanced in vitro physiological tissues remains a challenging issue, yet crucial for the future development of relevant tools for drug screening. In that regard, advanced technics such as human induced Pluripotent Stem Cells (hiPSCs) and organ-on-chip are promising technologies for the relevant reproduction of the in vivo micro physiology in in vitro culture condition ...
liver cirrhosis; liver transplant, etc ; Danio rerio; Lentivirus; ferroptosis; fibrosis; transfection; Show all 7 Subjects
Abstract:
... Liver fibrosis is a major disease that threatens people's health around the world. However, there is a lack of effective treatment to completely reverse liver fibrosis. Liver transplantation is currently the only curative option for patients with advanced cirrhosis. Ferroptosis is a newly discovered type of cell death and plays an important role in the process of liver fibrosis, but the specific m ...
... Severe acetaminophen (APAP)‐induced hepatic damage is the second most common cause for hepatic transplantation. Clinically, hepatic damage caused by APAP is treated using N‐acetyl‐L‐cysteine, which can induce numerous side effects. Naringin, a bioflavonoid abundant in grapefruit and other citrus fruits, displays marked antiinflammatory and antioxidant activities. Herein, we aimed to investigate th ...
liver; liver regeneration, etc ; chromatin; circadian rhythm; gene expression; genomics; hepatectomy; occupations; transcriptomics; Show all 9 Subjects
Abstract:
... Diurnal oscillations in gene expression are a hallmark of the liver internal clock and can be regulated by a variety of environmental stimuli. The circadian rhythm and liver regeneration (LR) are intimately linked. However, how they affect each other at the transcriptomic level is mainly unknown. Here, we revealed that partial hepatectomy (PHx)-induced LR led to reprogramming of rhythmic gene expr ...
liver; liver cirrhosis, etc ; cell communication; cytokines; genes; humans; mortality; research; transcriptome; transcriptomics; Show all 10 Subjects
Abstract:
... At present, there is no effective treatment for liver fibrosis, and treatment options are limited. Liver fibrosis remains a cancer with a high mortality rate. During liver injury, hepatic stellate cells transdifferentiate into myofibroblasts capable of proliferation, migration, and invasion. The transcriptomes of more than 60,000 human single cells were analyzed in 9 cirrhotic tissue samples and 1 ...
liver; liver neoplasms, etc ; biocompatibility; carbon nanotubes; death; metastasis; pancreas; precision medicine; prognosis; thermodynamics; Show all 10 Subjects
Abstract:
... Liver and pancreatic tumors are among the third leading causes of cancer-associated death worldwide. In addition to poor prognosis, both cancer types are diagnosed at advanced and metastatic stages without typical prior symptoms. Unfortunately, the existing theranostic approaches are inefficient in cancer diagnosis and treatment. Carbon nanotubes (CNTs) have attracted increasing attention in this ...
fatty liver; liver, etc ; biopsy; histology; lifestyle; metabolism; nutrition; nutritional intervention; odds ratio; placebos; Show all 10 Subjects
Abstract:
... The LISTEN trial (ClinicalTrial.gov accession: NCT01950884) is a phase IV 52 weeks double blind parallel randomized controlled trial that evaluated the effect of ezetimibe plus lifestyle and dietary intervention (eze) vs. lifestyle and dietary intervention alone (placebo) on progression and complications of non-alcoholic steatohepatitis (NASH) evaluated by liver histology. Forty patients with NASH ...
liver; liver diseases, etc ; disease progression; disease severity; drugs; peptides; pharmacokinetics; protein content; proteomics; Show all 9 Subjects
Abstract:
... Model-based assessment of drug pharmacokinetics in liver disease requires quantification of abundance and disease-related changes in hepatic enzymes and transporters. This study aimed to assess performance of three label-free methods [high N (HiN), intensity-based absolute quantification (iBAQ) and total protein approach (TPA)] against QconCAT-based targeted data in healthy and diseased (cancer an ...
... Nonalcoholic steatohepatitis, one of the most common chronic liver diseases, is a progressive form of nonalcoholic fatty liver disease accompanied by the development of liver fibrosis. Chlorogenic acid (CGA) is a natural polyphenolic compound. This study aims to observe the CGA-provided alleviation on liver fibrosis in methionine and choline deficient (MCD) diet-induced nonalcoholic steatohepatiti ...
fatty liver; liver; liver cirrhosis, etc ; actin; arachidonic acid; collagen; endothelial cells; fibrosis; high fat diet; immunoblotting; isozymes; methionine; models; muscles; phospholipase A2; phospholipases; therapeutics; Show all 17 Subjects
Abstract:
... Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, inflammatory responses and fibrosis. Our previous studies provided evidence that group IVA phospholipase A₂ (IVA-PLA₂), a key PLA₂ isozyme in the arachidonic acid cascade, is involved in the development of NASH. However, which types of cells are critical for the IVA-PLA₂-dependent onset and progression of NASH is unclear. We eluci ...
liver; liver neoplasms, etc ; antigens; blood serum; confidence interval; humans; perfluorooctane sulfonic acid; risk; toxicity; Show all 9 Subjects
Abstract:
... Per-/polyfluoroalkyl substances (PFASs) are widespread in global human blood, and have some toxic effects on liver. However, effects of PFAS exposure on human liver cancer (LC) risk are still not known. In this study, 203 LC patients and 203 controls were recruited, and their serum samples were collected between 2019 and 2021. We determined the residues of 12 PFASs in serum from all participants a ...
liver; liver diseases, etc ; alcohol drinking; antioxidants; apoptosis; ascorbic acid; diet; ethanol; necrosis; neutrophils; therapeutics; Show all 11 Subjects
Abstract:
... Alcoholic liver disease (ALD) comprises an important component in chronic liver diseases, and its clinical significance has increased due to the high consumption of alcohol worldwide. Vitamin C is a potent antioxidant, and several previous studies have suggested that its therapeutic role in ALD is derived from its antioxidant role. However, its anti-inflammatory role in ALD remains to be elucidate ...
... Radiologists should be aware of the findings of alveolar echinococcosis (AE) due to the diagnostic and management value of imaging. We are attempting to define the most common diagnostic imaging findings of liver AE, along with the prevalence and distribution of those findings. The patients’ US, CT, and MRI images were reviewed retrospectively. CT images were acquired with and without the administ ...
... Increasing evidences have confirmed the relationship between mitophagy and nonalcoholic steatohepatitis (NASH). The exact mechanism of upstream circular RNAs (circRNAs) regulating PTEN-induced putative kinase 1 (PINK1) mediated mitophagy and its contribution to NASH-related liver fibrosis was explored in our study. Primary hepatic stellate cells (PHSCs) from C57BL/6 mice transfected with small int ...