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1. Liver regeneration observed across the different classes of vertebrates from an evolutionary perspective

Author:
Delgado-Coello, Blanca
Source:
Heliyon 2021 v.7 no.3 pp. e06449
ISSN:
2405-8440
Subject:
liver; liver regeneration,   etc   ; cytokines; hyperplasia; longevity; xenobiotics;     Show all 6 Subjects
Abstract:
... The liver is a key organ that performs diverse functions such as metabolic processing of nutrients or disposal of dangerous substances (xenobiotics). Accordingly, it seems to be protected by several mechanisms throughout the life of organisms, one of which is compensatory hyperplasia, also known as liver regeneration. This review is a recapitulation of the scientific reports describing the differe ...
DOI:
10.1016/j.heliyon.2021.e06449

2. Autophagy-induced p62 accumulation is required for curcumol to regulate KLF5-mediated angiogenesis in liver sinusoidal endothelial cells

Author:
Gao, Liyuan; Yang, Xiang; Liang, Baoyu; Jia, Yan; Tan, Shanzhong; Chen, Anping; Cao, Peng; Zhang, Zili; Zheng, Shizhong; Sun, Lixia; Zhang, Feng; Shao, Jiangjuan
Source:
Toxicology 2021 v.452 pp. 152707
ISSN:
0300-483X
Subject:
liver; liver cirrhosis,   etc   ; angiogenesis; autophagy; models; toxicology; transcription factors;     Show all 7 Subjects
Abstract:
... Liver pathological angiogenesis is considered to be one of the key events in the development of liver fibrosis. Autophagy is a defense and stress regulation mechanism. However, whether autophagy regulates pathological angiogenesis in liver fibrosis is still questionable. Here, we aimed to study how curcumol regulated liver sinusoidal endothelial cells (LSECs) angiogenesis through autophagy. We fou ...
DOI:
10.1016/j.tox.2021.152707

3. Hypoxia maintains the fenestration of liver sinusoidal endothelial cells and promotes their proliferation through the SENP1/HIF-1α/VEGF signaling axis

Author:
Qing, Zhe; Huang, Hanfei; Yang, Shikun; Lin, Jie; Zeng, Zhong; Duan, Jian; Yuan, Bo; Ming, Tingfeng
Source:
Biochemical and biophysical research communications 2021 v.540 pp. 42-50
ISSN:
0006-291X
Subject:
liver; liver regeneration,   etc   ; genes; hypoxia; mice; neoplasms; normoxia; proteinases; research;     Show all 9 Subjects
Abstract:
... Liver sinusoidal endothelial cells (LSECs), which play a very critical role in liver regeneration, function in hypoxic environments, but few studies have elucidated the specific mechanism. As a hypoxia-sensitive gene, Sentrin/SUMO-specific protease 1(SENP1) is upregulated in solid tumors due to hypoxia and promotes tumor proliferation. We speculate that LSECs may upregulate SENP1 in hypoxic enviro ...
DOI:
10.1016/j.bbrc.2020.12.104

4. Liver graft harbouring hydatid disease: how far can we extend our donor pool?

Author:
Mrzljak, Anna; Lovric, Eva; Jadrijevic, Stipislav; Popic, Jelena; Pavicic-Saric, Jadranka; Vilibic-Cavlek, Tatjana
Source:
Parasitology research 2021 v.120 no.1 pp. 377-379
ISSN:
0932-0113
Subject:
liver; liver transplant,   etc   ; autoimmune hepatitis; parasitology; patients; research;     Show all 6 Subjects
Abstract:
... As the current demand for liver transplantation exceeds our donor pool, the donor search is shifted towards the extended donor criteria. The livers harbouring hydatid disease are a controversial source of grafts. We report the use of a liver graft harbouring hydatid disease in urgent liver transplantation in a patient with autoimmune hepatitis. Corroborated with previous experiences, we show that ...
DOI:
10.1007/s00436-020-06964-1

5. Pathogenesis of NASH and Promising Natural Products

Author:
LENG, Ying-Rong; ZHANG, Mei-Hui; LUO, Jian-Guang; ZHANG, Hao
Source:
Chinese journal of natural medicines 2021 v.19 no.1 pp. 12-27
ISSN:
1875-5364
Subject:
fatty liver; liver,   etc   ; ; human diseases; laboratory animals; pathogenesis; therapeutics;     Show all 7 Subjects
Abstract:
... Nonalcoholic steatohepatitis (NASH) is a common clinical condition that can lead to advanced liver diseases. The mechanism of the diaease progression, which is lacking effective therapy, remains obsure. Therefore, there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative therapies. To accomplish this goal, experimenta ...
DOI:
10.1016/S1875-5364(21)60002-X

6. Editorial “Nutrition and Dietary Intake for Liver-Related Diseases”

Author:
Stachowska, Ewa; Jakubczyk, Karolina; Maciejewska-Markiewicz, Dominika
Source:
Nutrients 2021 v.13 no.2
ISSN:
2072-6643
Subject:
liver diseases,   etc   ; food intake; therapeutics;     Show all 3 Subjects
Abstract:
... In this special issue, we focus on the role of nutrition in the therapy of nonalcoholic liver disease (NAFLD) [...] ...
DOI:
10.3390/nu13020390

7. Liver, Oxidative Stress and Metabolic Syndromes

Author:
Rezzani, Rita; Franco, Caterina
Source:
Nutrients 2021 v.13 no.2
ISSN:
2072-6643
Subject:
liver,   etc   ; metabolic syndrome; oxidative stress;     Show all 3 Subjects
Abstract:
... Today, talking about metabolic syndrome (MetS) and oxidative stress, can be risky [...] ...
DOI:
10.3390/nu13020301

8. Shh‐Yap signaling controls hepatic ductular reactions in CCl4‐induced liver injury

Author:
Jin, Lifang; Huang, Huarong; Ni, Jian; Shen, Jiayuan; Liu, Zuping; Li, Lijing; Fu, Shengmin; Yan, Junyan; Hu, Baowei
Source:
Environmental toxicology 2021 v.36 no.2 pp. 194-203
ISSN:
1520-4081
Subject:
liver; liver diseases; liver regeneration,   etc   ; carbon tetrachloride; ecotoxicology; hepatocytes; ligands; males; mice; therapeutics; Yap;     Show all 11 Subjects
Abstract:
... Carbon tetrachloride (CCl₄) exposure can induce hepatic ductular reactions. To date, however, the related mechanism remains largely unknown. Sonic hedgehog (Shh) and Yes‐associated protein (Yap) signaling are correlated with liver injury and regeneration. Herein, we investigated the role of Shh and Yap signaling in the fate of ductular reaction cells in CCl₄‐treated livers and the possible mechani ...
DOI:
10.1002/tox.23025

9. Baicalein attenuates acute liver injury by blocking NLRP3 inflammasome

Author:
Xiao, Ting; Cui, Yulong; Ji, Heyu; Yan, Lulu; Pei, Dongjie; Qu, Shuangquan
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 212-218
ISSN:
0006-291X
Subject:
liver; liver failure; liver function,   etc   ; antibodies; death; hepatocytes; inflammasomes; lipopolysaccharides; mice; research;     Show all 10 Subjects
Abstract:
... Infection and/or drug-mediated acute liver injury, the leading cause of lethal liver failure, is a critical health problem worldwide and lacks effective treatment. Here, we used Lipopolysaccharides (LPS)/D-galactosamine (D-gal)-treated primary hepatocytes to screen a natural library that contains 1130 chemicals. Baicalein in the library showed highest inhibitory effects against LPS/D-Gal-induced l ...
DOI:
10.1016/j.bbrc.2020.11.109

10. Inhaled exposure to air fresheners aggravated liver injury in a murine model of nonalcoholic fatty acid liver disease

Author:
Kim, Sanghwa; Lee, Ah Young; Cho, Myung-Haing
Source:
Heliyon 2021 v.7 no.3 pp. e06452
ISSN:
2405-8440
Subject:
fatty liver; liver; liver cirrhosis,   etc   ; air; animal models; cardiovascular diseases; collagen; diabetes; fatty acids; fibrosis; high fructose diet; liver failure; liver neoplasms; obesity; odors; phenotype; risk; risk assessment;     Show all 18 Subjects
Abstract:
... At present, the consumption and use of air fresheners (AFs) is rapidly increasing worldwide for the purposes of odor removal and to create a pleasant odor. Many recent studies have strongly suggested that the potentially hazardous chemicals emitted from AFs may be the primary source of indoor air pollutants and may cause adverse health effects. Despite the presence of hazardous chemicals in AFs, p ...
DOI:
10.1016/j.heliyon.2021.e06452

11. Yellow loosestrife (Lysimachia vulgaris var. davurica) ameliorates liver fibrosis in db/db mice with methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis

Author:
Son, Yang-Ju; Jung, Da Seul; Shin, Ji Min; Kim, Myungsuk; Yoo, Gyhye; Nho, Chu Won
Source:
BMC complementary medicine and therapies 2021 v.21 no.1 pp. 44
ISSN:
2662-7671
Subject:
fatty liver; liver; liver cirrhosis,   etc   ; Lysimachia; actin; alternative medicine; collagen; diet; drugs; gene expression; lipids; males; medicinal plants; muscles;     Show all 14 Subjects
Abstract:
... BACKGROUND: Nonalcoholic steatohepatitis (NASH), a liver disease caused by a nonalcoholic fatty liver, is increasing in incidence worldwide. Owing to the complexity of its pathogenic mechanisms, there are no therapeutic agents for this disease yet. The ideal drug for NASH needs to concurrently decrease hepatic lipid accumulation and exert anti-inflammatory, antifibrotic, and antioxidative effects ...
DOI:
10.1186/s12906-021-03212-6

12. Dietary lycopene attenuates cigarette smoke-promoted nonalcoholic steatohepatitis by preventing suppression of antioxidant enzymes in ferrets

Author:
Mustra Rakic, Jelena; Liu, Chun; Veeramachaneni, Sudipta; Wu, Dayong; Paul, Ligi; Ausman, Lynne M.; Wang, Xiang-Dong
Source:
The Journal of nutritional biochemistry 2021 v.91 pp. 108596
ISSN:
0955-2863
Subject:
fatty liver; liver; liver cirrhosis,   etc   ; ; beta-carotene; carcinogens; cigarettes; decline; diet; ferrets; fibrosis; lycopene; oxidative stress; risk factors; smoke;     Show all 15 Subjects
Abstract:
... Cigarette smoke (CS) is an independent risk factor in development of nonalcoholic steatohepatitis (NASH) and fibrosis. Lycopene, a carotenoid naturally occurring in tomatoes, has been shown to be a protective agent against tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced NASH. In the present study using a ferret model we investigated whether CS promotes NASH and whet ...
DOI:
10.1016/j.jnutbio.2021.108596

13. Development of highly functional bioengineered human liver with perfusable vasculature

Author:
Kim, Da-Hyun; Ahn, Jungho; Kang, Hyun Kyoung; Kim, Min-Soo; Kim, Nam-Gyo; Kook, Myung Geun; Choi, Soon Won; Jeon, Noo Li; Woo, Heung-Myong; Kang, Kyung-Sun
Source:
Biomaterials 2021 v.265 pp. 120417
ISSN:
0142-9612
Subject:
liver; liver cirrhosis; liver failure,   etc   ; animal models; biocompatible materials; blood; blood coagulation; graft rejection; humans; oligonucleotides; platelet aggregation; thrombosis;     Show all 12 Subjects
Abstract:
... Liver tissue engineering offers a promising strategy for liver failure patients. Since transplantation rejection resulting in vessel thrombosis is regarded as a major hurdle, vascular reconstruction is one of indispensable requirements of whole organ engineering. Here we demonstrated a novel strategy for reconstruction of a vascularized bioengineered human liver (VBHL) using decellularized liver s ...
DOI:
10.1016/j.biomaterials.2020.120417

14. Normothermic machine perfusion system satisfying oxygen demand of liver could maintain liver function more than subnormothermic machine perfusion

Author:
Yoshida, Kozue; Nakamura, Shunsuke; Sakamoto, Hiroki; Kondo, Mika; Chouno, Takehiro; Ikegami, Yasuhiro; Shirakigawa, Nana; Mizumoto, Hiroshi; Yamashita, Yo-ichi; Baba, Hideo; Ijima, Hiroyuki
Source:
Journal of bioscience and bioengineering 2021 v.131 no.1 pp. 107-113
ISSN:
1389-1723
Subject:
liver; liver function; liver transplant,   etc   ; ammonia; biochemical pathways; cold storage; lactic acid; metabolism; oxygen; oxygen consumption; temperature; viability;     Show all 12 Subjects
Abstract:
... Liver transplantation plays an important role in the medical field. To improve the quality of a donor liver, there is a need to establish a preservation system to prevent damage and maintain liver function. In response to this demand, machine perfusion (MP) has been proposed as a new liver preservation method instead of the conventional static cold storage. There is controversy about the optimal M ...
DOI:
10.1016/j.jbiosc.2020.08.011

15. Hepatocytes derived increased SAA1 promotes intrahepatic platelet aggregation and aggravates liver inflammation in NAFLD

Author:
Li, Daoyuan; Xie, Ping; Zhao, Su; Zhao, Jing; Yao, Yucheng; Zhao, Yan; Ren, Guangbing; Liu, Xingde
Source:
Biochemical and biophysical research communications 2021 v.555 pp. 54-60
ISSN:
0006-291X
Subject:
fatty liver; liver; liver cirrhosis,   etc   ; Toll-like receptors; adhesion; genes; hepatocytes; high fat diet; homeostasis; inflammation; insulin resistance; liver neoplasms; metabolic syndrome; obesity; palmitates; platelet aggregation; research; therapeutics;     Show all 18 Subjects
Abstract:
... Non-alcoholic fatty liver disease (NAFLD) is the pathological manifestation of metabolic syndrome in liver. Its pathological changes may evolve from the initial simple steatosis to non-alcoholic steatohepatitis, liver fibrosis and even liver cancer. Numerous studies have proved that platelets play a vital role in liver disease and homeostasis. Particularly, anti-platelet therapy can reduce intrahe ...
DOI:
10.1016/j.bbrc.2021.02.124

16. The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials

Author:
Izzo, Carmine; Annunziata, Monica; Melara, Giuseppe; Sciorio, Roberta; Dallio, Marcello; Masarone, Mario; Federico, Alessandro; Persico, Marcello
Source:
Nutrients 2021 v.13 no.3
ISSN:
2072-6643
Subject:
fatty liver; liver; liver cirrhosis,   etc   ; antioxidants; apoptosis; enzymes; fatty acid composition; glucose; humans; lipids; liver transplant; metabolic syndrome; metabolism; necrosis; resveratrol; survival rate;     Show all 16 Subjects
Abstract:
... Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders. Its administration can significantly increase the survival rate after liver transplantation, reduce fat deposition and ischemia-induced necrosis and apoptosis in Wistar rats. Resveratrol can provide Liver protection against chemical, cholestatic, and alcohol-mediated damage. It can improve glucose metabol ...
DOI:
10.3390/nu13030933

17. Gramicidin A-based unimolecular channel: cancer cell-targeting behavior and ion transport-induced apoptosis

Author:
Haoyang, Wei-Wei; Xiao, Qi; Ye, Zhongju; Fu, Yonghong; Zhang, Dan-Wei; Li, Jian; Xiao, Lehui; Li, Zhan-Ting; Hou, Jun-Li
Source:
Chemical communications 2021 v.57 no.9 pp. 1097-1100
ISSN:
1364-548X
Subject:
liver neoplasms,   etc   ; apoptosis; galactose; gramicidin; moieties;     Show all 5 Subjects
Abstract:
... A series of glycoside–peptide conjugates were prepared by engineering at the N-terminus of the natural peptide gramicidin A. The conjugate containing galactose moiety formed a unimolecular transmembrane channel and mediated ion transport to induce apoptosis of cancer cells. More importantly, it exhibited liver cancer cell-targeting behavior due to the galactose–asialoglycoprotein receptor recognit ...
DOI:
10.1039/d0cc08073j

18. Increase of complex I and reduction of complex II mitochondrial activity are possible adaptive effects provoked by fluoride exposure

Author:
Pereira, Heloisa Aparecida Barbosa Silva; Araújo, Tamara Teodoro; Dionizio, Aline; Trevizol, Juliana Sanches; Pereira, Fabrício Soares; Iano, Flávia Godoy; Faria Ximenes, Valdecir; Buzalaf, Marília Afonso Rabelo
Source:
Heliyon 2021 v.7 no.1 pp. e06028
ISSN:
2405-8440
Subject:
liver,   etc   ; bioinformatics; energy metabolism; fluorides; males; mitochondria;     Show all 6 Subjects
Abstract:
... Fluoride (F) can induce changes in the expression of several liver proteins, most of them localized in the mitochondria and its effect is dose- and time-dependent. This study analyzed the effect of distinct F concentrations and exposure periods on the mitochondrial activity of complex I-III and II-III in the liver. Thirty-six 21-day-old male Wistar rats were divided into 2 groups (n = 18) accordin ...
DOI:
10.1016/j.heliyon.2021.e06028

19. The NF-κB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis

Author:
Wu, Yin-Juan; He, Qing; Shang, Mei; Yin, Ying-Xuan; Li, Ye; Du, Xue; Li, Xue-Rong
Source:
Parasites & vectors 2021 v.14 no.1 pp. 152
ISSN:
1756-3305
Subject:
liver; liver cirrhosis,   etc   ; Clonorchis sinensis; Western blotting; antibodies; mice; phospholipase A2; precipitin tests;     Show all 8 Subjects
Abstract:
... BACKGROUND: The NF-κB signalling pathway has been reported to be related to liver fibrosis, and we investigated whether the NF-κB signalling pathway is involved in liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis (CssPLA2). Furthermore, expression of the receptor of CssPLA2 on the cell surface of hepatic stellate cells (HSCs) may greatly contribute to liver fibrosis. METHO ...
DOI:
10.1186/s13071-021-04663-z

20. Towards Evidence-based Control of Opisthorchis viverrini

Author:
Crellen, Thomas; Sithithaworn, Paiboon; Pitaksakulrat, Opal; Khuntikeo, Narong; Medley, Graham F.; Hollingsworth, T. Déirdre
Source:
Trends in parasitology 2021 v.37 no.5 pp. 370-380
ISSN:
1471-4922
Subject:
liver flukes; liver neoplasms,   etc   ; Opisthorchis viverrini; carcinogenicity; parasitology; South East Asia;     Show all 6 Subjects
Abstract:
... Transmission of the carcinogenic liver fluke Opisthorchis viverrini is ongoing across Southeast Asia. Endemic countries within the region are in different stages of achieving control. However, evidence on which interventions are the most effective for reducing parasite transmission, and the resulting liver cancer, is currently lacking. Quantitative modelling can be used to evaluate different contr ...
DOI:
10.1016/j.pt.2020.12.007