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1. Role of HSD17B13 in the liver physiology and pathophysiology

Author:
Su, Wen; Mao, Zhuo; Liu, Yiao; Zhang, Xiaoyan; Zhang, Weizhen; Gustafsson, Jan-Ake; Guan, Youfei
Source:
Molecular and cellular endocrinology 2019 v.489 pp. 119-125
ISSN:
0303-7207
Subject:
fatty liver; liver; liver neoplasms,   etc   ; biomarkers; cholesterol; enzymes; fatty acid metabolism; genomics; homeostasis; hormone metabolism; humans; mice; pathophysiology; patients; proteomics;     Show all 15 Subjects
Abstract:
... 17β-Hydroxysteroid dehydrogenases (HSD17Bs) comprise a large family of 15 members that are mainly involved in sex hormone metabolism. Some HSD17Bs enzymes also play key roles in cholesterol and fatty acid metabolism. Recent study showed that hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), an enzyme with unknown biological function, is a novel liver-specific lipid droplet (LD)-associated protein in ...
DOI:
10.1016/j.mce.2018.10.014

2. Effects of perinatal exposure to BPA, BPF and BPAF on liver function in male mouse offspring involving in oxidative damage and metabolic disorder

Author:
Meng, Zhiyuan; Tian, Sinuo; Yan, Jin; Jia, Ming; Yan, Sen; Li, Ruisheng; Zhang, Renke; Zhu, Wentao; Zhou, Zhiqiang
Source:
Environmental pollution 2019 v.247 pp. 935-943
ISSN:
0269-7491
Subject:
liver; liver diseases; liver function,   etc   ; antioxidant activity; glycogen; human health; lipid peroxidation; males; metabolic diseases; metabolites; mice; pollutants; progeny;     Show all 13 Subjects
Abstract:
... Bisphenols (BPs) are common environmental pollutants that are ubiquitous in the natural environment and can affect human health. In this study, we explored the effects of perinatal exposure to BPA, BPF and BPAF on liver function involving in oxidative damage and metabolic disorders in male mouse offspring. We found that BPA exposure impairs the antioxidant defense system, increases lipid peroxidat ...
DOI:
10.1016/j.envpol.2019.01.116

3. Imbalance in the glutathione system in Opisthorchis felineus infected liver promotes hepatic fibrosis

Author:
Perina, Ekaterina A.; Ivanov, Vladimir V.; Pershina, Alexandra G.; Perekucha, Natalya A.; Dzyuman, Anna N.; Kaminskii, Ilya P.; Saltykova, Irina V.; Sazonov, Alexey E.; Ogorodova, Ludmila M.
Source:
Acta tropica 2019 v.192 pp. 41-48
ISSN:
0001-706X
Subject:
liver; liver cirrhosis; liver flukes,   etc   ; Opisthorchis; acetylcysteine; animal models; collagen; glutathione; glutathione peroxidase; glutathione transferase; opisthorchiasis; oxidation; oxidative stress;     Show all 13 Subjects
Abstract:
... Although data on oxidative stress during liver fluke infection have been previously presented, a comprehensive study of the glutathione system that plays a crucial role in scavenging of reactive oxygen species (ROS) and detoxification of primary and secondary oxidation products has not been addressed yet. In the present study, the hepatic glutathione system was investigated in a hamster model of e ...
DOI:
10.1016/j.actatropica.2019.01.017

4. Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell

Author:
Zhang, Hanyan; Sun, Dandan; Wang, Guanzhen; Cui, Shichao; Field, Robert A.; Li, Jia; Zang, Yi
Source:
Biochemical and biophysical research communications 2019
ISSN:
0006-291X
Subject:
fatty liver; liver; liver cirrhosis,   etc   ; animal models; fibrosis; mice; noninsulin-dependent diabetes mellitus; pathogenesis; therapeutics; transforming growth factor beta;     Show all 10 Subjects
Abstract:
... Liver fibrosis occurs in most types of chronic liver diseases. The understanding of the pathogenesis of liver fibrosis has grown considerably, but the effective treatments are still lacking. Alogliptin, a classical Dipeptidyl peptidase-4 (DPP4) inhibitor with great effects on type 2 diabetes, has shown the potential to protect liver, but its effects on the progression of liver fibrosis have not be ...
DOI:
10.1016/j.bbrc.2019.02.065

5. Intestinal Barrier Function–Non-alcoholic Fatty Liver Disease Interactions and Possible Role of Gut Microbiota

Author:
Cui, Yizhe; Wang, Qiuju; Chang, Renxu; Zhou, Xiaocui; Xu, Chuang
Source:
Journal of agricultural and food chemistry 2019 v.67 no.10 pp. 2754-2762
ISSN:
1520-5118
Subject:
fatty liver; liver; liver cirrhosis,   etc   ; atherosclerosis; human health; insulin resistance; intestinal microorganisms; intestines; liver neoplasms; metabolic syndrome; noninsulin-dependent diabetes mellitus; obesity; pathogenesis;     Show all 13 Subjects
Abstract:
... Non-alcoholic fatty liver disease (NAFLD) is a metabolic stress liver injury that is closely related to obesity, insulin resistance, type 2 diabetes, atherosclerosis, and metabolic syndrome. The pathological features are diffuse hepatic vesicular steatosis, including non-alcoholic steatohepatitis, liver fibrosis, and even liver cancer. A variety of pathological outcomes cause serious harm to human ...
DOI:
10.1021/acs.jafc.9b00080

6. Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe

Author:
Ma, Ying; Tian, Haigang; Jin, Zhengyu; Li, Xiaoyong; Li, Yiping
Source:
RSC advances 2019 v.9 no.12 pp. 6510-6514
ISSN:
2046-2069
Subject:
liver,   etc   ; acetaminophen; fluorescent dyes; mice; monitoring; overdose;     Show all 6 Subjects
Abstract:
... A ratiometric fluorescent probe, BTPB, for the selective monitoring of hepatic peroxynitrite (ONOO⁻) in situ after acetaminophen (APAP) overdose has been developed. Our study provided direct evidence for supporting the generation of ONOO⁻ in APAP-induced liver injury. This new probe will be a useful tool for studying the roles of ONOO⁻in vivo. ...
DOI:
10.1039/c8ra10053e

7. Chitooligosaccharide supplementation prevents the development of high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in mice via the inhibition of cluster of differentiation 36 (CD36)

Author:
Zhao, Mengyao; Shen, Xin; Li, Xiaodan; Chen, Baoli; Fan, Liqiang; Xia, Quanming; Zhao, Liming
Source:
Journal of functional foods 2019 v.57 pp. 7-18
ISSN:
1756-4646
Subject:
fatty liver; liver,   etc   ; blood serum; chitooligosaccharides; cholesterol; messenger RNA; mice; molecular weight; triacylglycerols;     Show all 9 Subjects
Abstract:
... The effects of (GlcN)2-3 on the development of high fat diet-induced non-alcoholic fatty liver disease in C57BL/6J mice and the potential structural-functional relationship between different singular degrees of polymerization (DPs) COSs and CD36 activity were investigated. (GlcN)2-3 was found to significantly inhibit the levels of triglyceride, low density lipid protein and total cholesterol in th ...
DOI:
10.1016/j.jff.2019.03.048

8. Sphingolipid metabolism in non-alcoholic fatty liver diseases

Author:
Régnier, Marion; Polizzi, Arnaud; Guillou, Hervé; Loiseau, Nicolas
Source:
Biochimie 2019 v.159 pp. 9-22
ISSN:
0300-9084
Subject:
fatty liver; liver,   etc   ; biomarkers; ceramides; etiology; inflammation; insulin resistance; metabolism; moieties; triacylglycerols; weight gain;     Show all 11 Subjects
Abstract:
... Non-alcoholic fatty liver disease (NAFLD) involves a panel of pathologies starting with hepatic steatosis and continuing to irreversible and serious conditions like steatohepatitis (NASH) and hepatocarcinoma. NAFLD is multifactorial in origin and corresponds to abnormal fat deposition in liver. Even if triglycerides are mostly associated with these pathologies, other lipid moieties seem to be invo ...
DOI:
10.1016/j.biochi.2018.07.021

9. Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism

Author:
Cheng, Xiawei; Ma, Xiuling; Zhu, Qi; Song, Dandan; Ding, Xianming; Li, Lin; Jiang, Xiao; Wang, Xinyi; Tian, Rui; Su, Hua; Shen, Zhirong; Chen, She; Liu, Ting; Gong, Weihua; Liu, Wei; Sun, Qiming
Source:
Molecular cell 2019 v.73 no.4 pp. 788-802.e7
ISSN:
1097-2765
Subject:
liver; liver cirrhosis,   etc   ; acetylation; autophagy; dephosphorylation; droplets; glycogen; homeostasis; lipid metabolism; lipids; mice;     Show all 11 Subjects
Abstract:
... mTORC1 and GSK3 play critical roles in early stages of (macro)autophagy, but how they regulate late steps of autophagy remains poorly understood. Here we show that mTORC1 and GSK3-TIP60 signaling converge to modulate autophagosome maturation through Pacer, an autophagy regulator that was identified in our recent study. Hepatocyte-specific Pacer knockout in mice results in impaired autophagy flux, ...
DOI:
10.1016/j.molcel.2018.12.017

10. Cholangiocyte death in ductopenic cholestatic cholangiopathies: Mechanistic basis and emerging therapeutic strategies

Author:
Salas-Silva, Soraya; Simoni-Nieves, Arturo; Lopez-Ramirez, Jocelyn; Bucio, Leticia; Gómez-Quiroz, Luis E.; Gutiérrez-Ruiz, María Concepción; Roma, Marcelo G.
Source:
Life sciences 2019 v.218 pp. 324-339
ISSN:
0024-3205
Subject:
liver diseases; liver transplant,   etc   ; apoptosis; autophagy; bile ducts; cholelithiasis; death; epithelium; necroptosis; pathogenesis; patients;     Show all 11 Subjects
Abstract:
... Among hepatic diseases, cholestatic ductopenic cholangiopathies are poorly studied, and they are rarely given the importance they deserve, especially considering their high incidence in clinical practice. Although cholestatic ductopenic cholangiopathies have different etiologies and pathogenesis, all have the same target (the cholangiocyte) and similar mechanistic basis of cell death. Cholestatic ...
DOI:
10.1016/j.lfs.2018.12.044

11. Transgenic expression of tgfb1a induces hepatic inflammation, fibrosis and metastasis in zebrafish

Author:
Yan, Chuan; Yang, Qiqi; Gong, Zhiyuan
Source:
Biochemical and biophysical research communications 2019 v.509 no.1 pp. 175-181
ISSN:
0006-291X
Subject:
liver; liver cirrhosis,   etc   ; Danio rerio; carcinogenesis; fibrosis; gene expression; hepatocytes; hepatoma; humans; inflammation; metastasis; signal transduction;     Show all 12 Subjects
Abstract:
... TGFB signaling pathway plays a key role on liver disease progression. In our previous study, we have demonstrated the oncogenic ability of Tgfb signaling pathway as a chronic induction of tgfb1a specifically in hepatocytes led to both hepatocellular carcinoma (HCC) and cholangiocarcinoma in zebrafish. Here we would like to examine the potential mechanisms of Tgfb1a induced tumorigenesis. As majori ...
DOI:
10.1016/j.bbrc.2018.12.098

12. Liver function and dysfunction – a unique window into the physiological reach of ER stress and the unfolded protein response

Author:
Rutkowski, D. Thomas
Source:
TheFEBS journal 2019 v.286 no.2 pp. 356-378
ISSN:
1742-464X
Subject:
liver; liver function,   etc   ; endoplasmic reticulum; homeostasis; models; protein folding; unfolded protein response;     Show all 7 Subjects
Abstract:
... The unfolded protein response (UPR) improves endoplasmic reticulum (ER) protein folding in order to alleviate stress. Yet it is becoming increasingly clear that the UPR regulates processes well beyond those directly involved in protein folding, in some cases by mechanisms that fall outside the realm of canonical UPR signaling. These pathways are highly specific from one cell type to another, imply ...
DOI:
10.1111/febs.14389

13. Quercetin ameliorates autophagy in alcohol liver disease associated with lysosome through mTOR-TFEB pathway

Author:
Li, Yanyan; Chen, Man; Wang, Jun; Guo, Xiaoping; Xiao, Lin; Liu, Piyi; Liu, Liegang; Tang, Yuhan; Yao, Ping
Source:
Journal of functional foods 2019 v.52 pp. 177-185
ISSN:
1756-4646
Subject:
liver; liver diseases,   etc   ; alcohol abuse; autophagy; ethanol; hepatocytes; lysosomes; mice; quercetin;     Show all 9 Subjects
Abstract:
... This study aimed to investigate the effects of quercetin that is natural functional component in food on lysosome damage-mediated autophagy dysfunction in ALD and its possible underlying mechanisms. The C57BL/6J mice were divided into four groups and pair-fed with either regular or ethanol-containing Lieber De Carli liquids diets for 15 weeks. Quercetin was received by gavage. According to the pur ...
DOI:
10.1016/j.jff.2018.10.033

14. Non alcoholic fatty liver disease and risk of incident diabetes in subjects who are not obese

Author:
Sung, K.-C.; Seo, D.-C.; Lee, S.-J.; Lee, M.-Y.; Wild, S.H.; Byrne, C.D.
Source:
Nutrition, metabolism, and cardiovascular diseases 2019 v.29 no.5 pp. 489-495
ISSN:
0939-4753
Subject:
fatty liver; liver; liver cirrhosis,   etc   ; biomarkers; body mass index; cardiovascular diseases; diabetes; insulin resistance; men; metabolism; models; obesity; risk factors; waist circumference; women;     Show all 15 Subjects
Abstract:
... It is not known whether non alcoholic fatty liver disease (NAFLD) is a risk factor for diabetes in non obese, non centrally-obese subjects. Our aim was to investigate relationships between fatty liver, insulin resistance and a biomarker score for liver fibrosis with incident diabetes at follow up, in subjects who were neither obese nor centrally-obese.As many as 70,303 subjects with a body mass in ...
DOI:
10.1016/j.numecd.2019.01.016

15. A quantitative electrochemical assay for liver injury

Author:
Moed, Saundria; Zaman, Muhammad H.
Source:
Biosensors & bioelectronics 2019 v.131 pp. 74-78
ISSN:
0956-5663
Subject:
liver; liver diseases; liver function,   etc   ; Human immunodeficiency virus; alanine transaminase; biomarkers; biosensors; electrochemistry; hepatotoxicity; human resources; income; monitoring; patient care; patients; public health;     Show all 15 Subjects
Abstract:
... Liver diseases represent a vastly underestimated and historically neglected public health problem, disproportionately affecting those in low- and middle- income countries (LMICs). Patients on hepatotoxic medications, such as HIV and TB medications, need consistent monitoring of liver function as part of their standard of care. In high resource settings, this is often the case, but in LMICs traditi ...
DOI:
10.1016/j.bios.2019.02.032

16. Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2

Author:
Bi, Xiaoli; Yuan, Zhongwen; Qu, Biao; Zhou, Hua; Liu, Zhongqiu; Xie, Ying
Source:
Phytomedicine 2019 v.54 pp. 98-108
ISSN:
0944-7113
Subject:
liver; liver diseases; liver microsomes,   etc   ; absorption; animal models; antioxidants; bioavailability; cell lines; clinical trials; excretion; hepatocytes; humans; liquid chromatography; mass spectrometry; metabolites; pharmacokinetics; rats; solubility; therapeutics; transportation; transporters;     Show all 21 Subjects
Abstract:
... Although silybin serves as a well-known hepatoprotective agent with prominent anti-inflammatory, anti-oxidant and anti-fibrotic activities, its low bioavailability limits its application in the treatment of chronic liver diseases. However, novel formulation products with increased solubility were not sufficient to achieve pharmacologically meaningful concentrations of silybin in the clinical studi ...
DOI:
10.1016/j.phymed.2018.09.217

17. Adipose may actively delay progression of NAFLD by releasing tumor‐suppressing, anti‐fibrotic miR‐122 into circulation

Author:
Baranova, A.; Maltseva, D.; Tonevitsky, A.
Source:
Obesity reviews 2019 v.20 no.1 pp. 108-118
ISSN:
1467-7881
Subject:
fatty liver; liver; liver cirrhosis,   etc   ; blood flow; blood serum; carcinogenesis; chronic diseases; exosomes; hepatoma; mesenchymal stromal cells; microRNA; models; parenchyma (animal tissue); patients; secretion;     Show all 15 Subjects
Abstract:
... Nonalcoholic fatty liver disease (NAFLD) is the most common liver pathology. Here we propose tissue‐cooperative, homeostatic model of NAFLD. During early stages of NAFLD the intrahepatic production of miR‐122 falls, while the secretion of miRNA‐containing exosomes by adipose increases. Bloodstream carries exosome to the liver, where their miRNA cargo is released to regulate their intrahepatic targ ...
DOI:
10.1111/obr.12765

18. Paropisthorchis caninus Stephens, 1912: Synopsis of identity and pathological findings due to spontaneous infection in the liver of a street dog in Assam, India

Author:
Sarmah, Prabhat Chandra; Pathak, Debesh Chandra; Roy, Kuntola; Bhattacharjee, Kanta
Source:
Veterinary Parasitology: Regional Studies and Reports 2019 v.15 pp. 100253
ISSN:
2405-9390
Subject:
liver; liver diseases; liver flukes,   etc   ; Opisthorchis; bile ducts; cell proliferation; dogs; eggs; epithelium; hyperplasia; inflammation; miracidia; parenchyma (animal tissue); peduncle; India;     Show all 15 Subjects
Abstract:
... The present study describes a small liver fluke recovered at post-mortem and the pathological alteration produced by the parasite in the liver of a street dog from Assam, India. The spatulate parasite measured 3–4 mm in length and 1.0–1.25 mm in width with spiny body surface and showed a grossly visible peduncle projecting from the ventral surface at the anterior portion. The eggs of the parasite ...
DOI:
10.1016/j.vprsr.2018.11.005

19. Correction to: Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D

Author:
Khan, Shahida; Ali, Ashraf; Khan, Sarah; Bakillah, Ahmed; Damanhouri, Ghazi; Khan, Aziz; Makki, Ahmad; AlAnsari, Ibtehal; Banu, Naheed
Source:
Nutrition & metabolism 2018 v.15 no.1 pp. 21
ISSN:
1743-7075
Subject:
liver,   etc   ; neoplasms; vitamin D;     Show all 3 Subjects
Abstract:
... Following publication of the original article [1] one of the authors wrote to say that his name had been spelt incorrectly as Ahmed Makki instead of Ahmad Makki. ...
DOI:
10.1186/s12986-018-0257-z
PubMed:
29569628
PubMed Central:
PMC5857078

20. Correction to: Critical Roles of microRNAs in the Pathogenesis of Fatty Liver: New Advances, Challenges, and Potential Directions

Author:
Miao, Chenggui; Xie, Zhongwen; Chang, Jun
Source:
Biochemical genetics 2018 v.56 no.5 pp. 450
ISSN:
0006-2928
Subject:
fatty liver,   etc   ; microRNA; pathogenesis;     Show all 3 Subjects
Abstract:
... The original version of this article unfortunately contained an error in the Acknowledgement section. The corrected text has been given below: ...
DOI:
10.1007/s10528-018-9874-5