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1. Human adipose stem cell-derived extracellular nanovesicles for treatment of chronic liver fibrosis

Author:
Han, Hwa Seung; Lee, Hansang; You, DongGil; Nguyen, Van Quy; Song, Dae-Geun; Oh, Byeong Hoon; Shin, Sol; Choi, Ji Suk; Kim, Jae Dong; Pan, Cheol-Ho; Jo, Dong-Gyu; Cho, Yong Woo; Choi, Ki Young; Park, Jae Hyung
Source:
Journal of controlled release 2020 v.320 pp. 328-336
ISSN:
0168-3659
Subject:
liver; liver cirrhosis; liver transplant,   etc   ; actin; collagen; gelatinase A; humans; medicine; models; muscles; neoplasms; stem cells; tissue repair;     Show all 13 Subjects
Abstract:
... Liver fibrosis is an excessive wound healing process that occurs in response to liver damage depending on underlying aetiologies. Currently, there are no effective therapies and FDA-approved therapeutics for the treatment of liver fibrosis except liver transplantation. Multipotent adipose-derived stem cells (ADSCs) have received significant attention as regenerative medicine for liver fibrosis owi ...
DOI:
10.1016/j.jconrel.2020.01.042

2. Identification and prognostic impact of malnutrition in a population screened for liver transplantation

Author:
Oey, Rosalie C.; Aarts, Pim; Erler, Nicole S.; Metselaar, Herold J.; Lakenman, Patty L.M.; Riemslag Baas-van der Ree, Saskia; van Kemenade, Monique C.; van Buuren, Henk R.; de Man, Robert A.
Source:
Clinical nutrition ESPEN 2020 v.36 pp. 36-44
ISSN:
2405-4577
Subject:
liver; liver cirrhosis; liver transplant,   etc   ; males; malnutrition; muscle tissues; muscles; nutrition assessment; nutritional status; patients; sarcopenia; screening;     Show all 12 Subjects
Abstract:
... Sarcopenia is prevalent in patients with liver cirrhosis and is negatively associated with clinical outcomes. In a population screened for liver transplantation we aimed to assess the prevalence of abnormal nutritional status and to what extent a clinical screening tool is able to reliably select patients for extensive nutritional assessment including CT. We also evaluated which nutritional parame ...
DOI:
10.1016/j.clnesp.2020.02.013

3. Fatal chronic meningitis caused by Candida dubliniensis after liver transplantation

Author:
Gheshlaghi, Mariam; Helweg-Larsen, Jannik
Source:
Medical mycology case reports 2020 v.27 pp. 22-24
ISSN:
2211-7539
Subject:
liver transplant,   etc   ; Candida; case studies; hydrocephalus; meningitis;     Show all 5 Subjects
Abstract:
... We report a case of fatal chronic Candida dubliniensis meningitis complicated by severe hydrocephalus secondary to liver transplantation, in which diagnosis was considerably delayed. ...
DOI:
10.1016/j.mmcr.2019.12.009
PubMed:
31890490
PubMed Central:
PMC6926290

4. Exposure to growth hormone is associated with hepatic up-regulation of cPLA2α and COX

Author:
Piazza, Verónica G.; Matzkin, María E.; Cicconi, Nadia S.; Muia, Nadia V.; Valquinta, Sofía; Mccallum, Gregorio J.; Micucci, Giannina P.; Freund, Thomas; Zotta, Elsa; González, Lorena; Frungieri, Mónica B.; Fang, Yimin; Bartke, Andrzej; Sotelo, Ana I.; Miquet, Johanna G.
Source:
Molecular and cellular endocrinology 2020 v.509 pp. 110802
ISSN:
0303-7207
Subject:
liver; liver neoplasms,   etc   ; arachidonic acid; carcinogenesis; enzymes; hepatocytes; hyperplasia; hypertrophy; inflammation; males; metabolism; mice; somatotropin;     Show all 13 Subjects
Abstract:
... Continuously elevated levels of growth hormone (GH) during life in mice are associated with hepatomegaly due to hepatocytes hypertrophy and hyperplasia, chronic liver inflammation, elevated levels of arachidonic acid (AA) at young ages and liver tumors development at old ages. In this work, the hepatic expression of enzymes involved in AA metabolism, cPLA2α, COX1 and COX2 enzymes, was evaluated in ...
DOI:
10.1016/j.mce.2020.110802
PubMed:
32259636
PubMed Central:
PMC7211091

5. Compositional profiles, persistency and toxicity of polychlorinated naphthalene (PCN) congeners in edible cod liver products from 1972 to 2017

Author:
Falandysz, Jerzy; Fernandes, Alwyn R.
Source:
Environmental pollution 2020 v.260 pp. 114035
ISSN:
0269-7491
Subject:
cod liver oil; liver,   etc   ; European Union; chlorinated naphthalenes; combustion; dioxins; toxicity; Baltic Sea;     Show all 8 Subjects
Abstract:
... Edible cod liver products including cod liver oil and canned cod liver, sampled over the last five decades from the North Atlantic region, including the Baltic Sea were analysed for a set of persistent and toxicologically significant polychlorinated naphthalene (PCN) congeners with some of the highest relative potencies (dioxin-like toxicity) among PCNs. The targeted congeners showed a near-univer ...
DOI:
10.1016/j.envpol.2020.114035

6. Autophagic-CTSB-inflammasome axis modulates hepatic stellate cells activation in arsenic-induced liver fibrosis

Author:
Tao, Ye; Qiu, Tianming; Yao, Xiaofeng; Jiang, Liping; Wang, Ningning; Jia, Xue; Wei, Sen; Wang, Zhidong; Pei, Pei; Zhang, Jingyuan; Zhu, Yuhan; Yang, Guang; Liu, Xiaofang; Liu, Shuang; Sun, Xiance
Source:
Chemosphere 2020 v.242 pp. 124959
ISSN:
0045-6535
Subject:
liver; liver cirrhosis,   etc   ; arsenic; autophagy; cathepsin B; chronic exposure; collagen; fibrosis; inflammasomes; rats; receptors; sodium arsenite;     Show all 12 Subjects
Abstract:
... Long-term exposure to arsenic can cause liver injury and fibrosis. The activation of hepatic stellate cells (HSCs) plays an essential role in the process of liver fibrosis. We found that NaAsO₂ caused liver damage and fibrosis in vivo, accompanied by excessive collagen deposition and HSCs activation. In addition, NaAsO₂ upregulated autophagy flux, elevated the level of cytoplasmic cathepsin B (CTS ...
DOI:
10.1016/j.chemosphere.2019.124959

7. Inflammation: Cause or consequence of chronic cholestatic liver injury

Author:
Woolbright, Benjamin L.
Source:
Food and chemical toxicology 2020 v.137 pp. 111133
ISSN:
0278-6915
Subject:
liver; liver cirrhosis,   etc   ; autoimmunity; bile acids; biliary tract; cholestasis; clinical trials; cytotoxicity; inflammation; patients; therapeutics; xenobiotics;     Show all 12 Subjects
Abstract:
... Cholestasis is a result of obstruction of the biliary tracts. It is a common cause of liver pathology after exposure to toxic xenobiotics and during numerous other liver diseases. Accumulation of bile acids in the liver is thought to be a major driver of liver injury during cholestasis and can lead to eventual liver fibrosis and cirrhosis. As such, current therapy in the field of chronic liver dis ...
DOI:
10.1016/j.fct.2020.111133

8. Plasma metals and serum bilirubin levels in workers from manganese-exposed workers healthy cohort (MEWHC)

Author:
Ge, Xiaoting; Liu, Zhenfang; Hou, Qingzhi; Huang, Lulu; Zhou, Yanting; Li, Defu; Huang, Sifang; Luo, Xiaoyu; Lv, Yingnan; Li, Longman; Cheng, Hong; Chen, Xiang; Zan, Gaohui; Tan, Yanli; Liu, Chaoqun; Zou, Yunfeng; Yang, Xiaobo
Source:
Environmental pollution 2020 v.258 pp. 113683
ISSN:
0269-7491
Subject:
liver; liver function,   etc   ; alanine transaminase; aspartate transaminase; bilirubin; blood serum; copper; iron; molybdenum; regression analysis;     Show all 10 Subjects
Abstract:
... Few studies specifically address the possible associations between multiple-metal exposures and liver damage among the occupational population. This study aimed to explore the cross-sectional relationships of plasma metals with liver function parameters. For 571 on-the-spot workers in the manganese-exposed workers healthy cohort (MEWHC), we determined liver function parameters: total bilirubin (TB ...
DOI:
10.1016/j.envpol.2019.113683

9. Importance of OATP1B1 and 1B3 in the Liver Uptake of Luteolin and Its Consequent Glucuronidation Metabolites

Author:
Zhi, Hui; Yuan, Yuan; Zhang, Chunzhen; Jiang, Yiguo; Zhang, Hongjian; Wang, Cheng; Ruan, Jianqing
Source:
Journal of agricultural and food chemistry 2020 v.68 no.7 pp. 2063-2070
ISSN:
1520-5118
Subject:
liver; liver microsomes,   etc   ; bioavailability; glucuronosyltransferases; humans; intravenous injection; luteolin; metabolism; metabolites; mice; polypeptides; regioselectivity;     Show all 12 Subjects
Abstract:
... Luteolin is a typical flavonoid and broadly distributed in the plants. Oral bioavailability of luteolin is low owing to extensive metabolism. Regioselective glucuronidation by UDP-glucuronosyltransferases (UGTs) and liver uptake by organic anion transporting polypeptides (OATPs) of luteolin and consequent glucuronidation metabolites were studied. Luteolin-3′-O-glucuronide (L-3′-G) and luteolin-7-O ...
DOI:
10.1021/acs.jafc.9b06954

10. Oleuropein overrides liver damage in steatotic mice

Author:
Santini, Silvano Junior; Porcu, Cristiana; Tarantino, Giovanni; Amicarelli, Fernanda; Balsano, Clara
Source:
Journal of functional foods 2020 v.65 pp. 103756
ISSN:
1756-4646
Subject:
fatty liver; liver,   etc   ; antioxidant activity; antioxidants; females; heart; high fat diet; males; mice; oleuropein; oxidative stress;     Show all 11 Subjects
Abstract:
... Nonalcoholic fatty liver disease (NAFLD) is a common disease in which oxidative stress plays a main role in causing organ damage. Oleuropein (Ole) is a phenolic compound with both significant anti-inflammatory and antioxidant properties.The aim of the present work has been focused on investigating the mechanisms by which Ole is able to improve liver damage, in the presence of hepatic steatosis.We ...
DOI:
10.1016/j.jff.2019.103756

11. Biopsy needle integrated with multi-modal physical/chemical sensor array

Author:
Park, Jaeho; Jeong, Yongrok; Kim, Jayoung; Gu, Jimin; Wang, Joseph; Park, Inkyu
Source:
Biosensors & bioelectronics 2020 v.148 pp. 111822
ISSN:
0956-5663
Subject:
liver; liver neoplasms,   etc   ; biopsy; biosensors; electrical conductivity; glucose; humans; hydrogels; pH; phosphates; swine;     Show all 11 Subjects
Abstract:
... A biopsy needle integrated with a multi-modal physical/chemical sensor array for electrical conductivity, pH, and glucose concentration measurement was developed. A flexible device with an electrical conductivity sensor, a pH sensor, and a glucose sensor was fabricated on a flexible polyimide substrate with thickness less than 20 μm. Then, the sensor was directly integrated onto the surface of bio ...
DOI:
10.1016/j.bios.2019.111822

12. Comparison of liver regeneration after partial hepatectomy and acetaminophen-induced acute liver failure: A global picture based on transcriptome analysis

Author:
Bhushan, Bharat; Gunewardena, Sumedha; Edwards, Genea; Apte, Udayan
Source:
Food and chemical toxicology 2020 v.139 pp. 111186
ISSN:
0278-6915
Subject:
liver; liver failure; liver regeneration,   etc   ; acetaminophen; animal models; gene expression; hepatectomy; inflammation; interleukin-6; males; mice; overdose; transcription (genetics); transcriptomics; tumor necrosis factor-alpha; vascular endothelial growth factors;     Show all 16 Subjects
Abstract:
... Liver regenerates following surgical removal and after drug-induced liver injury (DILI). However, most of the mechanisms of liver regeneration were identified using partial hepatectomy (PHX) model rather than using DILI models. We compared mechanisms of liver regeneration following PHX and after acetaminophen (APAP) overdose, a DILI model, using transcriptomic approach. Kinetics of hepatocyte prol ...
DOI:
10.1016/j.fct.2020.111186

13. Mechanistic study of interaction between IL-22 and HCV core protein in the development of hepatocellular carcinoma among liver transplant recipients

Author:
Resham, Saleha; Saalim, Muhammad; Manzoor, Sobia; Ahmad, Hassam; Bangash, Tariq Ali; Latif, Amer; Jaleel, Shahla
Source:
Microbial pathogenesis 2020 v.142 pp. 104071
ISSN:
0882-4010
Subject:
liver; liver regeneration; liver transplant,   etc   ; Hepatitis C virus; carcinogenicity; cell cycle; hepatocytes; hepatoma; immunohistochemistry; interleukins; microscopy; patients; public health; viral proteins; viruses;     Show all 15 Subjects
Abstract:
... Hepatitis C virus (HCV) infects more than 170 million people worldwide that represents a major threat to global public health. Several viruses including HCV have developed mechanisms against the cellular responses essentially “hijacking” the antiviral responses generated against it. Interleukin 22 activated JAK-STAT pathways are responsible for several functions including liver regeneration, antiv ...
DOI:
10.1016/j.micpath.2020.104071

14. Pomegranate peel extract ameliorates liver fibrosis induced by carbon tetrachloride in rats through suppressing p38MAPK/Nrf2 pathway

Author:
Wei, Xianglan; Li, Siyao; Li, Tingting; Liu, Longzhu; Liu, Yuan; Wang, Hao; Zhou, Yong; Liang, Fanfan; Yu, Xiaojiang; Zang, Weijin; Zhao, Ming; Zhao, Zhenghang
Source:
Journal of functional foods 2020 v.65 pp. 103712
ISSN:
1756-4646
Subject:
liver; liver cirrhosis; liver function,   etc   ; animal models; carbon tetrachloride; death; enzyme activity; extracellular matrix; fibrosis; glutathione peroxidase; males; pomegranates; protective effect; rats; signal transduction; transforming growth factor beta;     Show all 16 Subjects
Abstract:
... Hepatic fibrosis is a chronic process characterized by excessive production of extracellular matrix in response to liver injury, which eventually leads to cirrhosis and even death. Growing evidence has demonstrated that pomegranate could efficiently reduce liver fibrosis in rats. Previous studies have also shown that Nrf2 activation alleviated liver fibrosis. However, whether the MAPK-Nrf2 pathway ...
DOI:
10.1016/j.jff.2019.103712

15. Design of Activatable NIR-II Molecular Probe for In Vivo Elucidation of Disease-Related Viscosity Variations

Author:
Dou, Kun; Huang, Weijing; Xiang, Yunhui; Li, Songjiao; Liu, Zhihong
Source:
Analytical chemistry 2020 v.92 no.6 pp. 4177-4181
ISSN:
1520-6882
Subject:
liver,   etc   ; fluorescence; fluorescent dyes; glycerol; image analysis; pH; screening; viscosity;     Show all 8 Subjects
Abstract:
... A clear elucidation of a disease-related viscosity change in vivo is significant yet highly challenging as well. Fluorescence imaging in the second near-infrared region (NIR-II, 1000–1700 nm) has gained increasing attention for observation in living organisms, but a viscosity-activatable fluorescent probe emitting at this region remains a vacancy. Herein, we report the first panel of a viscosity-a ...
DOI:
10.1021/acs.analchem.0c00634

16. Estimation of covariance matrix of multivariate longitudinal data using modified Choleksky and hypersphere decompositions

Author:
Lee, Keunbaik; Cho, Hyunsoon; Kwak, Min‐Sun; Jang, Eun Jin
Source:
Biometrics 2020 v.76 no.1 pp. 75-86
ISSN:
0006-341X
Subject:
fatty liver,   etc   ; biometry; heteroskedasticity; linear models; variance covariance matrix;     Show all 5 Subjects
Abstract:
... Linear models are typically used to analyze multivariate longitudinal data. With these models, estimating the covariance matrix is not easy because the covariance matrix should account for complex correlated structures: the correlation between responses at each time point, the correlation within separate responses over time, and the cross‐correlation between different responses at different times. ...
DOI:
10.1111/biom.13113

17. Nrf2 in liver toxicology

Author:
Taguchi, Keiko; Kensler, Thomas W.
Source:
Archives of pharmacal research 2020 v.43 no.3 pp. 337-349
ISSN:
0253-6269
Subject:
liver,   etc   ; drugs; genes; hepatotoxicity; metabolism; mice; toxicology; toxins; transcription factors;     Show all 9 Subjects
Abstract:
... Liver plays essential roles in the metabolism of many endogenous chemicals and exogenous toxicants. Mechanistic studies in liver have been at the forefront of efforts to probe the roles of bioactivation and detoxication of environmental toxins and toxicants in hepatotoxicity. Moreover, idiosyncratic hepatoxicity remains a key barrier in the clinical development of drugs. The now vast Nrf2 field em ...
DOI:
10.1007/s12272-019-01192-3
PubMed:
31782059
PubMed Central:
PMC7182086

18. 2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE-47) induces mitochondrial dysfunction and related liver injury via eliciting miR-34a-5p-mediated mitophagy impairment

Author:
Chen, Feng; Feng, Li; Zheng, Yuan-lin; Lu, Jun; Fan, Shao-hua; Shan, Qu; Zheng, Gui-hong; Wang, Yong-Jian; Wu, Dong-mei; Li, Meng-qiu; Wang, Qing-qing; Zhang, Zi-feng
Source:
Environmental pollution 2020 v.258 pp. 113693
ISSN:
0269-7491
Subject:
liver,   etc   ; hepatocytes; hepatotoxicity; human health; luciferase; mice; mitochondria; mitophagy; therapeutics;     Show all 9 Subjects
Abstract:
... 2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47) is associated with various adverse human health effects; however, the knowledge of its toxicity is still very limited. Mitochondrial injury has been observed in liver cells exposed to BDE-47 in vitro. Mitophagy impairment causes the accumulation of dysfunctional mitochondria, contributing to the pathological mechanisms of liver injury. The aim of this st ...
DOI:
10.1016/j.envpol.2019.113693

19. Advanced liver function assessment in patients with intestinal failure on long-term parenteral nutrition

Author:
Blüthner, Elisabeth; Bednarsch, Jan; Pape, Ulrich-Frank; Karber, Mirjam; Maasberg, Sebastian; Gerlach, Undine A.; Pascher, Andreas; Wiedenmann, Bertram; Pratschke, Johann; Stockmann, Martin
Source:
Clinical nutrition 2020 v.39 no.2 pp. 540-547
ISSN:
0261-5614
Subject:
liver; liver diseases; liver function,   etc   ; Limax; adults; citrulline; cross-sectional studies; early diagnosis; elasticity imaging techniques; hematologic tests; ileum; liver function tests; longitudinal studies; nutritional status; olive oil; parenteral feeding; patients; risk factors;     Show all 18 Subjects
Abstract:
... Intestinal failure associated liver disease (IFALD) is one of the leading complications and causes of deaths in adult patients receiving home parenteral nutrition for chronic intestinal failure (CIF). Early diagnosis of IFALD is key to alleviate the progression of hepatic dysfunction. The aim of this study was to evaluate the capability of noninvasive liver function tests.90 adult patients with CI ...
DOI:
10.1016/j.clnu.2019.02.039

20. Calibration strategies for elemental analysis of biological samples by LA-ICP-MS and LIBS – A review

Author:
Martinez, Mauro; Baudelet, Matthieu
Source:
Analytical and bioanalytical chemistry 2020 v.412 no.1 pp. 27-36
ISSN:
1618-2642
Subject:
liver,   etc   ; atomic absorption spectrometry; bones; brain; calibration; teeth; trace elements;     Show all 7 Subjects
Abstract:
... Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and laser-induced breakdown spectroscopy (LIBS) are widely accepted techniques for direct sampling of biological materials for elemental analysis, with increasing applications being reported over the recent years. This review is focused on the calibration materials used to quantify trace elements in different biological sample ...
DOI:
10.1007/s00216-019-02195-1