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1. Effects of perinatal exposure to BPA, BPF and BPAF on liver function in male mouse offspring involving in oxidative damage and metabolic disorder

Author:
Meng, Zhiyuan; Tian, Sinuo; Yan, Jin; Jia, Ming; Yan, Sen; Li, Ruisheng; Zhang, Renke; Zhu, Wentao; Zhou, Zhiqiang
Source:
Environmental pollution 2019 v.247 pp. 935-943
ISSN:
0269-7491
Subject:
liver; liver diseases; liver function,   etc   ; antioxidant activity; glycogen; human health; lipid peroxidation; males; metabolic diseases; metabolites; mice; pollutants; progeny;     Show all 13 Subjects
Abstract:
... Bisphenols (BPs) are common environmental pollutants that are ubiquitous in the natural environment and can affect human health. In this study, we explored the effects of perinatal exposure to BPA, BPF and BPAF on liver function involving in oxidative damage and metabolic disorders in male mouse offspring. We found that BPA exposure impairs the antioxidant defense system, increases lipid peroxidat ...
DOI:
10.1016/j.envpol.2019.01.116

2. Quercetin ameliorates autophagy in alcohol liver disease associated with lysosome through mTOR-TFEB pathway

Author:
Li, Yanyan; Chen, Man; Wang, Jun; Guo, Xiaoping; Xiao, Lin; Liu, Piyi; Liu, Liegang; Tang, Yuhan; Yao, Ping
Source:
Journal of functional foods 2019 v.52 pp. 177-185
ISSN:
1756-4646
Subject:
liver; liver diseases,   etc   ; alcohol abuse; autophagy; ethanol; hepatocytes; lysosomes; mice; quercetin;     Show all 9 Subjects
Abstract:
... This study aimed to investigate the effects of quercetin that is natural functional component in food on lysosome damage-mediated autophagy dysfunction in ALD and its possible underlying mechanisms. The C57BL/6J mice were divided into four groups and pair-fed with either regular or ethanol-containing Lieber De Carli liquids diets for 15 weeks. Quercetin was received by gavage. According to the pur ...
DOI:
10.1016/j.jff.2018.10.033

3. Paropisthorchis caninus Stephens, 1912: Synopsis of identity and pathological findings due to spontaneous infection in the liver of a street dog in Assam, India

Author:
Sarmah, Prabhat Chandra; Pathak, Debesh Chandra; Roy, Kuntola; Bhattacharjee, Kanta
Source:
Veterinary Parasitology: Regional Studies and Reports 2019 v.15 pp. 100253
ISSN:
2405-9390
Subject:
liver; liver diseases; liver flukes,   etc   ; Opisthorchis; bile ducts; cell proliferation; dogs; eggs; epithelium; hyperplasia; inflammation; miracidia; parenchyma (animal tissue); peduncle; India;     Show all 15 Subjects
Abstract:
... The present study describes a small liver fluke recovered at post-mortem and the pathological alteration produced by the parasite in the liver of a street dog from Assam, India. The spatulate parasite measured 3–4 mm in length and 1.0–1.25 mm in width with spiny body surface and showed a grossly visible peduncle projecting from the ventral surface at the anterior portion. The eggs of the parasite ...
DOI:
10.1016/j.vprsr.2018.11.005

4. Correction to: Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D

Author:
Khan, Shahida; Ali, Ashraf; Khan, Sarah; Bakillah, Ahmed; Damanhouri, Ghazi; Khan, Aziz; Makki, Ahmad; AlAnsari, Ibtehal; Banu, Naheed
Source:
Nutrition & metabolism 2018 v.15 no.1 pp. 21
ISSN:
1743-7075
Subject:
liver,   etc   ; neoplasms; vitamin D;     Show all 3 Subjects
Abstract:
... Following publication of the original article [1] one of the authors wrote to say that his name had been spelt incorrectly as Ahmed Makki instead of Ahmad Makki. ...
DOI:
10.1186/s12986-018-0257-z

5. Blood lead and cadmium levels associated with hematological and hepatic functions in patients from an e-waste-polluted area

Author:
Chen, Yanrong; Xu, Xijin; Zeng, Zhijun; Lin, Xueqiong; Qin, Qilin; Huo, Xia
Source:
Chemosphere 2019 v.220 pp. 531-538
ISSN:
0045-6535
Subject:
liver; liver function,   etc   ; atomic absorption spectrometry; blood; cadmium; chronic exposure; human health; lead; patients; toxicity; trace elements; China;     Show all 12 Subjects
Abstract:
... Chronic exposures to toxic trace metals have hazardous effects on human health, especially exposure to lead (Pb) and cadmium (Cd). Blood Pb and Cd reflect toxicity on human health. A total of 267 hospitalized patients, of which 158 were from Guiyu (exposed group) in China, and 109 from Jinping (reference group), were recruited in this study. Blood Pb and Cd were measured by graphite furnace atomic ...
DOI:
10.1016/j.chemosphere.2018.12.129

6. Mapping the triglyceride distribution in NAFLD human liver by MALDI imaging mass spectrometry reveals molecular differences in micro and macro steatosis

Author:
Alamri, Hussam; Patterson, Nathan Heath; Yang, Ethan; Zoroquiain, Pablo; Lazaris, Anthoula; Chaurand, Pierre; Metrakos, Peter
Source:
Analytical and bioanalytical chemistry 2019 v.411 no.4 pp. 885-894
ISSN:
1618-2642
Subject:
fatty liver; liver,   etc   ; desorption; droplets; fatty acids; hepatocytes; histopathology; humans; image analysis; ionization; lipogenesis; mass spectrometry; phospholipids; triacylglycerols;     Show all 14 Subjects
Abstract:
... Hepatic lipid accumulation, mainly in the form of triglycerides (TGs), is the hallmark of non-alcoholic fatty liver disease (NAFLD). To date, the spatial distribution of individual lipids in NAFLD-affected livers is not well characterized. This study aims to map the triglyceride distribution in normal human liver samples and livers with NAFLD and cirrhosis with imaging mass spectrometry (MALDI IMS ...
DOI:
10.1007/s00216-018-1506-8

7. Evaluation of the enantioselective in vitro metabolism of the chiral pesticide fipronil employing a human model: Risk assessment through in vitro-in vivo correlation and prediction of toxicokinetic parameters

Author:
Carrão, Daniel Blascke; dos Reis Gomes, Isabel Cristina; Barbosa Junior, Fernando; de Oliveira, Anderson Rodrigo Moraes
Source:
Food and chemical toxicology 2019 v.123 pp. 225-232
ISSN:
0278-6915
Subject:
liver; liver microsomes,   etc   ; bioaccumulation; enantiomers; enantioselectivity; fipronil; humans; models; nontarget organisms; pest control; pharmacokinetics; prediction; risk assessment; toxicity;     Show all 14 Subjects
Abstract:
... The chiral pesticide fipronil is employed as a racemic mixture to control pests. Although there are no enantioselective differences in the fipronil enantiomer activities toward target organisms, fipronil enantiomers may exhibit enantioselective differences in their bioaccumulation, toxicity, and metabolism toward non-target organisms, including humans. The present work aims to provide significant ...
DOI:
10.1016/j.fct.2018.10.060

8. Schistosome-Induced Fibrotic Disease: The Role of Hepatic Stellate Cells

Author:
Carson, Jack P.; Ramm, Grant A.; Robinson, Mark W.; McManus, Donald P.; Gobert, Geoffrey N.
Source:
Trends in parasitology 2018 v.34 no.6 pp. 524-540
ISSN:
1471-4922
Subject:
liver; liver cirrhosis,   etc   ; collagen; eggs; fibrosis; parasites; schistosomiasis; tissues;     Show all 8 Subjects
Abstract:
... Hepatic fibrosis is a common pathology in various liver diseases. Hepatic stellate cells (HSCs) are the main cell type responsible for collagen deposition and fibrosis formation in the liver. Schistosomiasis is characterised by granulomatous fibrosis around parasite eggs trapped within the liver and other host tissues. This response is facilitated by the recruitment of immune cells and the activat ...
DOI:
10.1016/j.pt.2018.02.005

9. Investigating enhancer evolution with massively parallel reporter assays

Author:
Kwon, Soo Bin; Ernst, Jason
Source:
Genome biology 2018 v.19 no.1 pp. 114
ISSN:
1474-760X
Subject:
liver,   etc   ; enhancer elements; evolution; genome;     Show all 4 Subjects
Abstract:
... A recent study in Genome Biology has characterized the evolution of candidate hominoid-specific liver enhancers by using massively parallel reporter assays (MPRAs). ...
DOI:
10.1186/s13059-018-1502-5

10. Correction to: Histological liver chances in Swiss mice caused by tannery effluent

Author:
Rabelo, LetíciaMartins; Guimarães, AbraãoTiago Batista; de Souza, JoyceMoreira; da Silva, WellingtonAlves Mizael; de Oliveira Mendes, Bruna; de Oliveira Ferreira, Raíssa; de Lima Rodrigues, AlineSueli; Malafaia, Guilherme
Source:
Environmental science and pollution research international 2018 v.25 no.16 pp. 16267-16268
ISSN:
0944-1344
Subject:
liver,   etc   ; histology; mice; tannery effluents;     Show all 4 Subjects
Abstract:
... There is a problem in the original publication of this paper (Figure 2 Graphs are in Portuguese). Shown in this paper is the correct version. ...
DOI:
10.1007/s11356-018-1805-9

11. Liver cell therapy: is this the end of the beginning?

Author:
Alwahsh, SalamahM.; Rashidi, Hassan; Hay, DavidC.
Source:
Cellular and molecular life sciences 2018 v.75 no.8 pp. 1307-1324
ISSN:
1420-682X
Subject:
liver; liver diseases; liver transplant,   etc   ; animal models; cell transplantation; hepatocytes; humans; stem cells;     Show all 8 Subjects
Abstract:
... The prevalence of liver diseases is increasing globally. Orthotopic liver transplantation is widely used to treat liver disease upon organ failure. The complexity of this procedure and finite numbers of healthy organ donors have prompted research into alternative therapeutic options to treat liver disease. This includes the transplantation of liver cells to promote regeneration. While successful, ...
DOI:
10.1007/s00018-017-2713-8

12. Laminin-521 promotes quiescence in isolated stellate cells from rat liver

Author:
Rohn, Friederike; Kordes, Claus; Castoldi, Mirco; Götze, Silke; Poschmann, Gereon; Stühler, Kai; Herebian, Diran; Benk, Amelie S.; Geiger, Fania; Zhang, Tingyu; Spatz, Joachim P.; Häussinger, Dieter
Source:
Biomaterials 2018
ISSN:
0142-9612
Subject:
liver; liver diseases; liver regeneration,   etc   ; fibrosis; genes; glass; laminin; phenotype; polystyrenes; rats; stem cells;     Show all 11 Subjects
Abstract:
... The laminin α5 protein chain is an element of basement membranes and important to maintain stem cells. Hepatic stellate cells (HSC) are liver-resident mesenchymal stem cells, which reside in a quiescent state on a basement membrane-like structure in the space of Dissé. In the present study, laminin α5 chain was detected in the space of Dissé of normal rat liver. Since HSC are critical for liver re ...
DOI:
10.1016/j.biomaterials.2018.07.008

13. Liver transplantation and the use of KAVA: Case report

Author:
Becker, Matheus William; Lourençone, Emerson Matheus Silva; De Mello, Alexandre Formighieri; Branco, Aline; Filho, Edison Moraes Rodrigues; Blatt, Celso Ronaldo; Mallmann, Carlos Augusto; Schneider, Maurício; Caregnato, Rita Catalina Aquino; Blatt, Carine Raquel
Source:
Phytomedicine 2019 v.56 pp. 21-26
ISSN:
0944-7113
Subject:
liver; liver failure; liver transplant,   etc   ; Piper methysticum; active ingredients; adulterants; algorithms; case studies; chemical constituents of plants; death; harvesting; health care workers; hepatotoxicity; kava; patients; risk; tranquilizers; Brazil; France; Germany;     Show all 20 Subjects
Abstract:
... Self-medication and the belief that herbal products are free of health risks are common in Brazil. The kava (Piper methysticum), known for its anxiolytic action, has a widespread popular use. Hepatotoxicity of kava is reported, including cases of liver transplantation and death. The kava had its use prohibited or restricted in countries like Germany, France, among others. Toxicity may be related t ...
DOI:
10.1016/j.phymed.2018.08.011

14. Hepatoprotection of Herpetospermum caudigerum Wall. against CCl4-induced liver fibrosis on rats

Author:
Li, Ming-Hui; Feng, Xin; Deng Ba, Da Ji; Chen, Cheng; Ruan, Ling-Yu; Xing, Yue-Xiao; Chen, Lv-Yi; Zhong, Ge-Jia; Wang, Jun-Song
Source:
Journal of ethnopharmacology 2019 v.229 pp. 1-14
ISSN:
0378-8741
Subject:
liver; liver cirrhosis; liver function,   etc   ; Herpetospermum; amino acids; antioxidants; blood serum; collagen; death; fibrosis; hepatoma; hepatoprotective effect; hyaluronoglucosaminidase; intraperitoneal injection; laminin; metabolomics; nucleic acids; oxidative stress; rats; tissues; traditional medicine;     Show all 21 Subjects
Abstract:
... Herpetospermum caudigerum Wall. (HCW) is a traditional Tibetan medicine, which has been used to ameliorate liver injuries in the folk.Liver fibrosis has been recognized as a major lesion of the liver that leads to liver cirrhosis/hepatocarcinoma and even to death in the end. This study aims to demonstrate the protective effect of HCW against CCl4-induced liver injury in rats and to explore the und ...
DOI:
10.1016/j.jep.2018.09.033

15. Assessment of muscle mass depletion in chronic liver disease; dual-energy x-ray absorptiometry compared with computed tomography

Author:
Lindqvist, Catarina; Brismar, Torkel B.; Majeed, Ammar; Wahlin, Staffan
Source:
Nutrition 2019 v.61 pp. 93-98
ISSN:
0899-9007
Subject:
liver diseases; liver transplant,   etc   ; adults; ascites; bone density; computed tomography; dual-energy X-ray absorptiometry; hospitals; lean body mass; medical records; muscles; patients; skeletal muscle;     Show all 13 Subjects
Abstract:
... The aim of this study was to perform intermethod comparisons between the following three measures of muscle mass depletion in patients eligible for liver transplantation: 1) fat-free mass index (FFMI) measured by dual-energy x-ray absorptiometry (DXA), 2) appendicular skeletal muscle mass index (ASMI) measured by DXA, and 3) skeletal muscle index (SMI) measured at the third lumbar level by compute ...
DOI:
10.1016/j.nut.2018.10.031

16. Contamination of organohalogen chemicals and hepatic steatosis in common kingfisher (Alcedo atthis) breeding at a nature reserve near e-waste recycling sites in South China

Author:
Wu, Jiang-Ping; Peng, Ying; Zhi, Hui; Chen, Xiao-Yun; Wu, Si-Kang; Tao, Lin; Zeng, Yan-Hong; Luo, Xiao-Jun; Mai, Bi-Xian
Source:
The Science of the total environment 2019 v.659 pp. 561-567
ISSN:
0048-9697
Subject:
fatty liver; liver,   etc   ; Alcedinidae; DDT (pesticide); bioaccumulation; birds; breeding; conservation areas; electronic wastes; histology; lipids; pollution; polybrominated diphenyl ethers; polychlorinated biphenyls; recycling; wildlife; China;     Show all 17 Subjects
Abstract:
... Severe pollution of organohalogen compounds (OHCs) including PBDEs, PCBs and DDTs is demonstrated in e-waste recycling sites and metropolis in South China, but relatively little is known of their impacts on wildlife that inhabits nature reserves in this region, especially those located at the neighborhood areas of e-waste recycling sites. In the present study, PBDEs, PCBs and DDTs as well as liver ...
DOI:
10.1016/j.scitotenv.2018.12.395

17. Raw orange intake is associated with higher prevalence of non-alcoholic fatty liver disease in an adult population

Author:
Xia, Yang; Lu, Zuolin; Lu, Min; Liu, Mingyue; Liu, Li; Meng, Ge; Yu, Bin; Wu, Hongmei; Bao, Xue; Gu, Yeqing; Shi, Hongbin; Wang, Honglei; Sun, Shaomei; Wang, Xing; Zhou, Ming; Jia, Qiyu; Xiang, Huiling; Sun, Zhong; Niu, Kaijun
Source:
Nutrition 2019 v.60 pp. 252-260
ISSN:
0899-9007
Subject:
fatty liver; liver,   etc   ; adults; antioxidants; cohort studies; confidence interval; flavonoids; food frequency questionnaires; fructose; fruits; odds ratio; oranges; public health; regression analysis; risk factors; ultrasonography;     Show all 16 Subjects
Abstract:
... Non-alcoholic fatty liver disease (NAFLD) is one of the most common public health issues worldwide. Oranges are the most popular fruit consumed in the world. Admittedly, flavonoids in oranges act as antioxidants and improve liver steatosis. However, oranges also are rich in fructose, which is a risk factor in the progress of NAFLD. Therefore, we hypothesize that orange intake may be a double-edged ...
DOI:
10.1016/j.nut.2018.09.033

18. Treatment with myo-inositol attenuates binding of the carbohydrate-responsive element-binding protein to the ChREBP-β and FASN genes in rat nonalcoholic fatty liver induced by high-fructose diet

Author:
Shimada, Masaya; Ichigo, Yutaro; Shirouchi, Bungo; Takashima, Shigeo; Inagaki, Mizuho; Nakagawa, Tomoyuki; Hayakawa, Takashi
Source:
Nutrition research 2019 v.64 pp. 49-55
ISSN:
0271-5317
Subject:
fatty liver; liver,   etc   ; NADP-glucose-6-phosphate dehydrogenase; dietary supplements; fatty acids; fatty-acid synthase; fructose; gene expression; genes; myo-inositol; rats; response elements; triacylglycerols;     Show all 13 Subjects
Abstract:
... Dietary supplementation with the major lipotrope myo-inositol (MI) potently reduces triglyceride (TG) content and expression levels of the fatty acid synthesis genes, for example, fatty acid synthase (FASN), in rat nonalcoholic fatty liver induced by high-fructose diet. Fatty acid synthesis genes are regulated by the carbohydrate-responsive element-binding protein (ChREBP) that exists in 2 isoform ...
DOI:
10.1016/j.nutres.2019.01.002

19. Characterizations and hepatoprotective effect of polysaccharides from Mesona blumes against tetrachloride-induced acute liver injury in mice

Author:
Wang, Wenjie; Jiang, Lian; Ren, Yanming; Shen, Mingyue; Xie, Jianhua
Source:
International journal of biological macromolecules 2019 v.124 pp. 788-795
ISSN:
0141-8130
Subject:
liver; liver diseases,   etc   ; alanine transaminase; antioxidants; aspartate transaminase; blood serum; body weight; glutathione; hepatoprotective effect; interleukin-1beta; lipid peroxidation; mice; polysaccharides; superoxide dismutase; tissues; tumor necrosis factor-alpha;     Show all 16 Subjects
Abstract:
... Mesona blumes polysaccharide (MBP), a primary active component extracted from Mesona blumes, has a number of bioactivities. Nevertheless, hepatoprotective activity of MBP has been rarely reported. The purpose of this study is to investigate hepatoprotective effects of MBP on acute liver injury in mice. Results indicated that the MBP could remarkably decrease the increased levels of aspartate amino ...
DOI:
10.1016/j.ijbiomac.2018.11.260

20. Low fat but not soy protein isolate was an effective intervention to reduce nonalcoholic fatty liver disease progression in C57BL/6J mice: monitored by a novel quantitative ultrasound (QUS) method

Author:
Rowles, Joe L.; Han, Aiguo; Miller, Rita J.; Kelly, Jamie R.; Applegate, Catherine C.; Wallig, Matthew A.; O’Brien, William D.; Erdman, John W.
Source:
Nutrition research 2019 v.63 pp. 95-105
ISSN:
0271-5317
Subject:
fatty liver; liver,   etc   ; disease course; high fat diet; histology; inflammation; lipid content; lipids; low fat diet; mice; phenotype; soy protein isolate;     Show all 12 Subjects
Abstract:
... Untreated nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) lead to irreversible liver damage. We hypothesized that a low-fat diet (LFD) or a high-fat diet (HFD) with soy protein isolate (SPI) would be an effective intervention to halt or reverse NAFLD progression. To test these hypotheses, we conducted 2 studies. In the first study, we fed an HFD to 7-week-old C57BL ...
DOI:
10.1016/j.nutres.2018.12.003