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1. The Lactobacillus as a Probiotic: Focusing on Liver Diseases

Author:
Jin-Ju Jeong; Hee Jin Park; Min Gi Cha; Eunju Park; Sung-Min Won; Raja Ganesan; Haripriya Gupta; Yoseph Asmelash Gebru; Satya Priya Sharma; Su Been Lee; Goo Hyun Kwon; Min Kyo Jeong; Byeong Hyun Min; Ji Ye Hyun; Jung A Eom; Sang Jun Yoon; Mi Ran Choi; Dong Joon Kim; Ki Tae Suk
Source:
Microorganisms 2022 v.10 no.2 pp. -
ISSN:
2076-2607
Subject:
liver; liver diseases,   etc   ; Lactobacillus; gastrointestinal system; probiotics;     Show all 5 Subjects
Abstract:
... Over the past decade, scientific evidence for the properties, functions, and beneficial effects of probiotics for humans has continued to accumulate. Interest in the use of probiotics for humans has increased tremendously. Among various microorganisms, probiotics using bacteria have been widely studied and commercialized, and, among them, Lactobacillus is representative. This genus contains about ...
DOI:
10.3390/microorganisms10020288

2. The dynamics of cell death patterns and regeneration during acute liver injury in mice

Author:
Shuai Shao; Yu Zhang; Guantong Li; Zhenjun Yu; Yingying Cao; Lina Zheng; Kun Zhang; Xiaohui Han; Zhemin Shi; Hongmei Cui; Xiaomeng Song; Wei Hong; Tao Han
Source:
FEBS Open Bio 2022 v.12 no.5 pp. 1061-1074
ISSN:
2211-5463
Subject:
liver; liver diseases; liver regeneration,   etc   ; autophagy; blood serum; cytokines; models; mortality; prognosis; pyroptosis; therapeutics; transaminases;     Show all 12 Subjects
Abstract:
... Acute liver injury is a serious clinical syndrome with multiple causes and unclear pathological process. Here, CCl₄‐ and D‐galactosamine/lipopolysaccharide (D‐gal/LPS)‐induced acute liver injury was established to explore the cell death patterns and determine whether or not liver regeneration occurred. In CCl₄‐induced hepatic injury, three phases, including the early, progressive, and recovery pha ...
DOI:
10.1002/2211-5463.13383

3. Exosomal FZD-7 Expression Is Modulated by Different Lifestyle Interventions in Patients with NAFLD

Author:
Maria Principia Scavo; Nicoletta Depalo; Federica Rizzi; Livianna Carrieri; Grazia Serino; Isabella Franco; Caterina Bonfiglio; Pasqua Letizia Pesole; Raffaele Cozzolongo; Vito Gianuzzi; Maria Lucia Curri; Alberto Ruben Osella; Gianluigi Giannelli
Source:
Nutrients 2022 v.14 no.6 pp. -
ISSN:
2072-6643
Subject:
fatty liver; liver; liver cirrhosis,   etc   ; alcohol drinking; biomarkers; biopsy; evolution; exosomes; hypertriglyceridemia; inflammation; lifestyle; prognosis; toxicity;     Show all 13 Subjects
Abstract:
... Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition characterized from hypertriglyceridemia and hepatic fat accumulation, in the absence of alcohol intake. NAFLD starts as steatosis (NAFL), and the continued injury relative to the toxic fat induces inflammation, steatohepatitis (NASH), and HCC. One of the factors determining liver degeneration during the evolution of NAFLD is a ...
DOI:
10.3390/nu14061133

4. Parental and transgenerational impairments of thyroid endocrine system in zebrafish by 2,4,6-tribromophenol

Author:
Yuxi Zhou; Juanjuan Fu; Min Wang; Yongyong Guo; Lihua Yang; Jian Han; Bingsheng Zhou
Source:
Journal of environmental sciences (China) 2023 v.124 pp. 291-299
ISSN:
1001-0742
Subject:
liver,   etc   ; Danio rerio; adults; bioaccumulation; brain; chemical analysis; flame retardants; histopathology; humans; pollution; progeny; toxicity; transcription (genetics); China;     Show all 14 Subjects
Abstract:
... Many environmental contaminants could be transmitted from parents and generate impairments to their progeny. The 2,4,6-tribromophenol (TBP), a novel brominated flame retardant which has been frequently detected in various organisms, was supposed to be bioaccumulated and intergenerational transmitted in human beings. Previous studies revealed that TBP could disrupt thyroid endocrine system in zebra ...
DOI:
10.1016/j.jes.2021.09.022

5. Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL

Author:
Pan Li; Yuwei Chen; Xiumei Ke; Ruoyu Zhang; Ling Zuo; Meng Wang; Zhiwei Chen; Xianqin Luo; Jianwei Wang
Source:
Archives of biochemistry and biophysics 2022 v.722 pp. 109236
ISSN:
0003-9861
Subject:
fatty liver; liver; liver cirrhosis,   etc   ; Scutellaria baicalensis; alanine transaminase; alcohols; aspartate transaminase; baicalin; biophysics; hydrolysis; lipolysis; triacylglycerols;     Show all 12 Subjects
Abstract:
... Baicalin is a flavonoid compound abundant in multiple edible and medicinal plants such as Scutellaria baicalensis Georgi. In this study, we provide evidence to support the fact that baicalin ameliorates alcohol-induced hepatic steatosis via regulating SREBP1c elicited PNPLA3 competitive binding to ATGL. Results showed that baicalin significantly attenuated the development of metabolic disorders an ...
DOI:
10.1016/j.abb.2022.109236

6. Free fatty acid-induced miR-181a-5p stimulates apoptosis by targeting XIAP and Bcl2 in hepatic cells

Author:
Ajay K. Yadav; Teja Naveen Sata; Daksh Verma; Amit K. Mishra; Amrendra K. Sah; Md. Musa Hossain; Kishor Pant; Senthil K. Venugopal
Source:
Life sciences 2022 v.301 pp. 120625
ISSN:
0024-3205
Subject:
fatty liver; liver,   etc   ; RNA; apoptosis; diet; hepatocytes; phosphorylation; protein content;     Show all 8 Subjects
Abstract:
... Non-alcoholic fatty liver disease is one of the major health concerns in the World. The dietary free fatty acids (FFAs) affect the metabolic status of the hepatocytes by modulating cellular pathways. In this study, we showed that free fatty acids stimulate apoptosis by upregulating miR-181a-5p expression, which in turn targets XIAP and Bcl2. Huh7 cells were incubated with FFAs for 72 h and the exp ...
DOI:
10.1016/j.lfs.2022.120625

7. Influence of CPM-dependent sorting on the multi-omics profile of hepatocyte-like cells matured in microscale biochips

Author:
Mathieu Danoy; Stéphane Poulain; Benedikt Scheidecker; Rachid Jellali; Yannick Tauran; Marjorie Leduc; Johanna Bruce; Francoise Gilard; Bertrand Gakiere; Hiroshi Arakawa; Yukio Kato; Soo Hyeon Kim; Taketomo Kido; Atsushi Miyajima; Yasuyuki Sakai; Eric Leclerc
Source:
Biochemical engineering journal 2022 v.181 pp. 108408
ISSN:
1369-703X
Subject:
liver; liver regeneration,   etc   ; RNA; drugs; humans; metabolomics; multiomics; proteomics; reproduction;     Show all 9 Subjects
Abstract:
... Liver modeling in disease via advanced in vitro physiological tissues remains a challenging issue, yet crucial for the future development of relevant tools for drug screening. In that regard, advanced technics such as human induced Pluripotent Stem Cells (hiPSCs) and organ-on-chip are promising technologies for the relevant reproduction of the in vivo micro physiology in in vitro culture condition ...
DOI:
10.1016/j.bej.2022.108408

8. Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice

Author:
Sha Huang; Yuhua Wang; Shuwen Xie; Yuqi Lai; Chan Mo; Ting Zeng; Shanshan Kuang; Chuying Zhou; Zhiyun Zeng; Yuyao Chen; Shaohui Huang; Lei Gao; Zhiping Lv
Source:
Phytomedicine 2022 v.101 pp. 154117
ISSN:
0944-7113
Subject:
liver cirrhosis; liver transplant,   etc   ; Danio rerio; Lentivirus; ferroptosis; fibrosis; transfection;     Show all 7 Subjects
Abstract:
... Liver fibrosis is a major disease that threatens people's health around the world. However, there is a lack of effective treatment to completely reverse liver fibrosis. Liver transplantation is currently the only curative option for patients with advanced cirrhosis. Ferroptosis is a newly discovered type of cell death and plays an important role in the process of liver fibrosis, but the specific m ...
DOI:
10.1016/j.phymed.2022.154117

9. Naringin alleviates acetaminophen‐induced acute liver injury by activating Nrf2 via CHAC2 upregulation

Author:
Xiaohan Zhai; Tiantian Dai; Zhongchao Chi; Zirui Zhao; Gaolei Wu; Shilei Yang; Deshi Dong
Source:
Environmental toxicology 2022 v.37 no.6 pp. 1332-1342
ISSN:
1520-4081
Subject:
liver; liver failure; liver transplant,   etc   ; Citrus; acetaminophen; acetylcysteine; antioxidant enzymes; apoptosis; cations; cytokines; ecotoxicology; grapefruits; hepatitis; hepatotoxicity; naringin; protective effect;     Show all 16 Subjects
Abstract:
... Severe acetaminophen (APAP)‐induced hepatic damage is the second most common cause for hepatic transplantation. Clinically, hepatic damage caused by APAP is treated using N‐acetyl‐L‐cysteine, which can induce numerous side effects. Naringin, a bioflavonoid abundant in grapefruit and other citrus fruits, displays marked antiinflammatory and antioxidant activities. Herein, we aimed to investigate th ...
DOI:
10.1002/tox.23487

10. Interplay between liver circadian rhythm and regeneration after PHx

Author:
Saisai Wei; Qiang Zheng; Yu Pan; Yunwan Xu; Jiacheng Tang; Xiujun Cai
Source:
Genomics 2022 v.114 no.1 pp. 1-8
ISSN:
0888-7543
Subject:
liver; liver regeneration,   etc   ; chromatin; circadian rhythm; gene expression; genomics; hepatectomy; occupations; transcriptomics;     Show all 9 Subjects
Abstract:
... Diurnal oscillations in gene expression are a hallmark of the liver internal clock and can be regulated by a variety of environmental stimuli. The circadian rhythm and liver regeneration (LR) are intimately linked. However, how they affect each other at the transcriptomic level is mainly unknown. Here, we revealed that partial hepatectomy (PHx)-induced LR led to reprogramming of rhythmic gene expr ...
DOI:
10.1016/j.ygeno.2021.11.023

11. Key genes in the liver fibrosis process are mined based on single-cell transcriptomics

Author:
Liang Ai; Qiang Wang; Ke Cheng
Source:
Biochemical and biophysical research communications 2022 v.598 pp. 131-137
ISSN:
0006-291X
Subject:
liver; liver cirrhosis,   etc   ; cell communication; cytokines; genes; humans; mortality; research; transcriptome; transcriptomics;     Show all 10 Subjects
Abstract:
... At present, there is no effective treatment for liver fibrosis, and treatment options are limited. Liver fibrosis remains a cancer with a high mortality rate. During liver injury, hepatic stellate cells transdifferentiate into myofibroblasts capable of proliferation, migration, and invasion. The transcriptomes of more than 60,000 human single cells were analyzed in 9 cirrhotic tissue samples and 1 ...
DOI:
10.1016/j.bbrc.2022.01.094

12. Application of carbon nanotubes in sensing/monitoring of pancreas and liver cancer

Author:
Elham Ahmadian; Dawid Janas; Aziz Eftekhari; Najme Zare
Source:
Chemosphere 2022 v.302 pp. 134826
ISSN:
0045-6535
Subject:
liver; liver neoplasms,   etc   ; biocompatibility; carbon nanotubes; death; metastasis; pancreas; precision medicine; prognosis; thermodynamics;     Show all 10 Subjects
Abstract:
... Liver and pancreatic tumors are among the third leading causes of cancer-associated death worldwide. In addition to poor prognosis, both cancer types are diagnosed at advanced and metastatic stages without typical prior symptoms. Unfortunately, the existing theranostic approaches are inefficient in cancer diagnosis and treatment. Carbon nanotubes (CNTs) have attracted increasing attention in this ...
DOI:
10.1016/j.chemosphere.2022.134826

13. Lifestyle versus ezetimibe plus lifestyle in patients with biopsy-proven non-alcoholic steatohepatitis (LISTEN): A double-blind randomised placebo-controlled trial

Author:
Davide Noto; Salvatore Petta; Antonina Giammanco; Rossella Spina; Daniela Cabibbi; Rossana Porcasi; Rosalia Caldarella; Marcello Ciaccio; Roberto Muratore; Angelo B. Cefalù; Antonio Craxi; Maurizio Averna
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 v.32 no.5 pp. 1288-1291
ISSN:
0939-4753
Subject:
fatty liver; liver,   etc   ; biopsy; histology; lifestyle; metabolism; nutrition; nutritional intervention; odds ratio; placebos;     Show all 10 Subjects
Abstract:
... The LISTEN trial (ClinicalTrial.gov accession: NCT01950884) is a phase IV 52 weeks double blind parallel randomized controlled trial that evaluated the effect of ezetimibe plus lifestyle and dietary intervention (eze) vs. lifestyle and dietary intervention alone (placebo) on progression and complications of non-alcoholic steatohepatitis (NASH) evaluated by liver histology. Forty patients with NASH ...
DOI:
10.1016/j.numecd.2022.01.024

14. Proteomic quantification of perturbation to pharmacokinetic target proteins in liver disease

Author:
Areti-Maria Vasilogianni; Eman El-Khateeb; Zubida M. Al-Majdoub; Sarah Alrubia; Amin Rostami-Hodjegan; Jill Barber; Brahim Achour
Source:
Journal of proteomics 2022 v.263 pp. 104601
ISSN:
1874-3919
Subject:
liver; liver diseases,   etc   ; disease progression; disease severity; drugs; peptides; pharmacokinetics; protein content; proteomics;     Show all 9 Subjects
Abstract:
... Model-based assessment of drug pharmacokinetics in liver disease requires quantification of abundance and disease-related changes in hepatic enzymes and transporters. This study aimed to assess performance of three label-free methods [high N (HiN), intensity-based absolute quantification (iBAQ) and total protein approach (TPA)] against QconCAT-based targeted data in healthy and diseased (cancer an ...
DOI:
10.1016/j.jprot.2022.104601

15. Chlorogenic acid alleviated liver fibrosis in methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice and its mechanism

Author:
Hui Miao; Hao Ouyang; Qian Guo; Mengjuan Wei; Bin Lu; Guoyin Kai; Lili Ji
Source:
Journal of nutritional biochemistry 2022 v.106 pp. 109020
ISSN:
0955-2863
Subject:
fatty liver; liver; liver cirrhosis,   etc   ; biogenesis; blood serum; chlorogenic acid; choline; collagen; diet; extracellular matrix; humans; methionine; mitochondria; nucleoproteins; peroxisome proliferator-activated receptor gamma;     Show all 15 Subjects
Abstract:
... Nonalcoholic steatohepatitis, one of the most common chronic liver diseases, is a progressive form of nonalcoholic fatty liver disease accompanied by the development of liver fibrosis. Chlorogenic acid (CGA) is a natural polyphenolic compound. This study aims to observe the CGA-provided alleviation on liver fibrosis in methionine and choline deficient (MCD) diet-induced nonalcoholic steatohepatiti ...
DOI:
10.1016/j.jnutbio.2022.109020

16. Endothelial group IVA phospholipase A2 promotes hepatic fibrosis with sinusoidal capillarization in the early stage of non-alcoholic steatohepatitis in mice

Author:
Eri Kawashita; Takeyoshi Ozaki; Keiichi Ishihara; Chihiro Kashiwada; Satoshi Akiba
Source:
Life sciences 2022 v.294 pp. 120355
ISSN:
0024-3205
Subject:
fatty liver; liver; liver cirrhosis,   etc   ; actin; arachidonic acid; collagen; endothelial cells; fibrosis; high fat diet; immunoblotting; isozymes; methionine; models; muscles; phospholipase A2; phospholipases; therapeutics;     Show all 17 Subjects
Abstract:
... Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, inflammatory responses and fibrosis. Our previous studies provided evidence that group IVA phospholipase A₂ (IVA-PLA₂), a key PLA₂ isozyme in the arachidonic acid cascade, is involved in the development of NASH. However, which types of cells are critical for the IVA-PLA₂-dependent onset and progression of NASH is unclear. We eluci ...
DOI:
10.1016/j.lfs.2022.120355

17. Per-/polyfluoroalkyl substance concentrations in human serum and their associations with liver cancer

Author:
Linping Cao; Yu Guo; Yuanchen Chen; Jiawei Hong; Jian Wu; Jin Hangbiao
Source:
Chemosphere 2022 v.296 pp. 134083
ISSN:
0045-6535
Subject:
liver; liver neoplasms,   etc   ; antigens; blood serum; confidence interval; humans; perfluorooctane sulfonic acid; risk; toxicity;     Show all 9 Subjects
Abstract:
... Per-/polyfluoroalkyl substances (PFASs) are widespread in global human blood, and have some toxic effects on liver. However, effects of PFAS exposure on human liver cancer (LC) risk are still not known. In this study, 203 LC patients and 203 controls were recruited, and their serum samples were collected between 2019 and 2021. We determined the residues of 12 PFASs in serum from all participants a ...
DOI:
10.1016/j.chemosphere.2022.134083

18. Vitamin C alleviates alcoholic liver injury by suppressing neutrophil infiltration in senescence marker protein 30-knockout mice irrespective of its antioxidant effects

Author:
Su-Min Baek; Seoung-Woo Lee; Young-Jin Lee; Seong-Kyoon Choi; Hee-Yeon Kim; Min-Soo Seo; Soo-Eun Sung; A-Rang Lee; Tae-Un Kim; Se-Hyeon Han; Jun-Hyeok Son; Sang-Joon Park; Tae-Hwan Kim; Kyu-Shik Jeong; Jin-Kyu Park
Source:
Life sciences 2022 v.297 pp. 120228
ISSN:
0024-3205
Subject:
liver; liver diseases,   etc   ; alcohol drinking; antioxidants; apoptosis; ascorbic acid; diet; ethanol; necrosis; neutrophils; therapeutics;     Show all 11 Subjects
Abstract:
... Alcoholic liver disease (ALD) comprises an important component in chronic liver diseases, and its clinical significance has increased due to the high consumption of alcohol worldwide. Vitamin C is a potent antioxidant, and several previous studies have suggested that its therapeutic role in ALD is derived from its antioxidant role. However, its anti-inflammatory role in ALD remains to be elucidate ...
DOI:
10.1016/j.lfs.2021.120228

19. Imaging Aspects of Hepatic Alveolar Echinococcosis: Retrospective Findings of a Surgical Center in Turkey

Author:
Mecit Kantarci; Sonay Aydin; Suat Eren; Hayri Ogul; Okan Akhan
Source:
Pathogens 2022 v.11 no.2 pp. -
ISSN:
2076-0817
Subject:
liver,   etc   ; diffusivity; echinococcosis; protocols;     Show all 4 Subjects
Abstract:
... Radiologists should be aware of the findings of alveolar echinococcosis (AE) due to the diagnostic and management value of imaging. We are attempting to define the most common diagnostic imaging findings of liver AE, along with the prevalence and distribution of those findings. The patients’ US, CT, and MRI images were reviewed retrospectively. CT images were acquired with and without the administ ...
DOI:
10.3390/pathogens11020276

20. CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis

Author:
Zi-Xin Xu; Jing-Ze Li; Qin Li; Ming-Yi Xu; Hui-Yi Li
Source:
Biochemical and biophysical research communications 2022 v.610 pp. 35-42
ISSN:
0006-291X
Subject:
fatty liver; liver cirrhosis,   etc   ; bioinformatics; computer software; fibrosis; fluorescent antibody technique; microRNA; mitochondria; mitophagy; research;     Show all 10 Subjects
Abstract:
... Increasing evidences have confirmed the relationship between mitophagy and nonalcoholic steatohepatitis (NASH). The exact mechanism of upstream circular RNAs (circRNAs) regulating PTEN-induced putative kinase 1 (PINK1) mediated mitophagy and its contribution to NASH-related liver fibrosis was explored in our study. Primary hepatic stellate cells (PHSCs) from C57BL/6 mice transfected with small int ...
DOI:
10.1016/j.bbrc.2022.04.008