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lungfunction, etc ; energy; mechanics; respiratory system; Show all 4 Subjects
Abstract:
... There is increasing interest in the use of the forced oscillation technique (FOT) or oscillometry to characterize respiratory mechanics in healthy and diseased individuals. FOT, a complementary method to traditional pulmonary function testing, utilizes a range of oscillatory frequencies superimposed on tidal breathing to measure the functional relationship between airway pressure and flow. This pa ...
lungfunction, etc ; cognition; patients; quality control; Show all 4 Subjects
Abstract:
... Respiratory oscillometry is a different modality of pulmonary function testing that is increasingly used in a clinical and research setting to provide information regarding lung mechanics. Respiratory oscillometry is conducted through three acceptable measurements of tidal breathing and can be performed with minimal contraindications. Young children and patients who cannot perform spirometry due t ...
lungfunction, etc ; heritability; lungs; single nucleotide polymorphism; Show all 4 Subjects
Abstract:
... Genetic influence on lung functions has been identified in previous studies; however, the relative longitudinal effects of genetic factors and their interactions with smoking on lung function remain unclear. Here, we identified the longitudinal effects of genetic variants on lung function by determining single nucleotide polymorphism (SNP) heritability and genetic correlations, and by analyzing in ...
lungfunction, etc ; models; oxidative stress; particulates; pollution; Show all 5 Subjects
Abstract:
... Decreased lung function is an early hazard of respiratory damage from fine particulate matter (PM₂.₅) exposure. Limited studies have explored the association between PM₂.₅-bound polycyclic aromatic hydrocarbons (PAHs) and lung function, but studies at the personal level in healthy young adults are scarce. Here, we assessed personal PM₂.₅ and PM₂.₅-bound PAH levels in a panel of 45 healthy young ad ...
lungfunction, etc ; adults; ambient temperature; asthma; cold; longitudinal studies; Show all 6 Subjects
Abstract:
... Few studies have explored the role of ambient temperature in asthma exacerbation. We aimed to explore the association of temperature with diurnal peak expiratory flow (PEF) variation and asthma exacerbation. We developed a longitudinal study among asthmatic adults in 18 Chinese cities. Subjects recorded PEF in dynamic pulmonary function monitoring from 2017 to 2020. Linear mixed-effect model and g ...
lungfunction, etc ; bioreactors; medicine; rats; respiratory tract diseases; ultrastructure; Show all 6 Subjects
Abstract:
... Repeated injury to airway tissue can impair lung function and cause chronic lung disease, such as chronic obstructive pulmonary disease. Advances in regenerative medicine and bioreactor technologies offer opportunities to produce lab-grown functional tissue and organ constructs that can be used to screen drugs, model disease, and engineer tissue replacements. Here, a miniaturized bioreactor couple ...
lungfunction, etc ; adolescence; air; air pollution; biomarkers; mortality; people; pregnancy outcome; Show all 8 Subjects
Abstract:
... People who relocate to a new environment may experience health effects from a change in ambient air pollution. We undertook a literature review of studies of such relocations and health effects and report the results as a narrative analysis. Fifteen articles of heterogeneous designs met the inclusion criteria. Four short-term (relocation duration less than six months) and three long-term (relocati ...
lungfunction, etc ; air; case studies; human resources; lungs; nitric oxide; research; Show all 7 Subjects
Abstract:
... Working in a moisture-damaged building can cause different symptoms and effects on lung functions. Moving to a clean environment, it is believed to reduce symptoms and alleviate potential adverse health effects. This case study monitors the health effects of personnel in one school building before and after all school activities were transferred from a moisture-damaged school building to clean pre ...
lungfunction, etc ; COVID-19 infection; air; medicine; models; patients; tidal volume; Show all 7 Subjects
Abstract:
... Mechanical ventilator is a machine that is mechanically designed to deliver breathable air in and out of the lungs to provide a breathing mechanism for a patient who is physically unable to breathe, it is an indispensable life-support device in critical care medicine and medical emergencies such as scenarios during the COVID-19 pandemic. This research presents a model design of the pneumatic circu ...
lungfunction, etc ; breathing; lungs; microRNA; particulates; proteasome endopeptidase complex; pulmonary fibrosis; Show all 7 Subjects
Abstract:
... Long-term inhalation of fine particulate matter (PM₂.₅) can cause serious effects on the respiratory system. It might be attributed to the fact that PM₂.₅ could directly enter and deposit in lung tissues. We established models of PM₂.₅ exposure in vivo and in vitro to explore the adverse effects of ambient PM₂.₅ on pulmonary and its potential pathogenic mechanisms. Our results showed that PM₂.₅ ex ...
lungfunction, etc ; adults; body condition; bronchoconstriction; males; obesity; plethysmography; risk; tidal volume; Show all 9 Subjects
Abstract:
... Obesity is a nutritional disorder commonly diagnosed in adult cats that has been associated with an increased risk of different chronic diseases including respiratory diseases. The main objective of this study is to define if there is a relation between lung function measured by barometric whole-body plethysmography and obesity in cats with bronchoconstriction. Fifty-three cats were included in th ...
lungfunction, etc ; air; cement; computed tomography; dust; environment; pulmonary emphysema; risk factors; Show all 8 Subjects
Abstract:
... Cement dust exposure (CDE) can be a risk factor for pulmonary disease, causing changes in segmental airways and parenchymal lungs. This study investigates longitudinal alterations in quantitative computed tomography (CT)-based metrics due to CDE. We obtained CT-based airway structural and lung functional metrics from CDE subjects with baseline CT and follow-up CT scans performed three years later. ...
lungfunction, etc ; DNA; DNA methylation; cohort studies; epigenetics; epigenome; normal distribution; statistical inference; Show all 8 Subjects
Abstract:
... In genome-wide epigenetic studies, it is of great scientific interest to assess whether the effect of an exposure on a clinical outcome is mediated through DNA methylations. However, statistical inference for causal mediation effects is challenged by the fact that one needs to test a large number of composite null hypotheses across the whole epigenome. Two popular tests, the Wald-type Sobel’s test ...
lungfunction, etc ; biomedical research; data analysis; data collection; gene expression; models; proteomics; statistics; Show all 8 Subjects
Abstract:
... Analyzing multi-source data, which are multiple views of data on the same subjects, has become increasingly common in molecular biomedical research. Recent methods have sought to uncover underlying structure and relationships within and/or between the data sources, and other methods have sought to build a predictive model for an outcome using all sources. However, existing methods that do both are ...
lungfunction, etc ; adverse effects; atomic absorption spectrometry; chromates; chromium; cohort studies; environment; monitoring; Show all 8 Subjects
Abstract:
... Hexavalent chromium [Cr(VI)] and its compounds have been associated with various respiratory diseases, while few studies have attempted to determine its adverse effect on lung function. To explore the potential early indicators of health surveillance for respiratory diseases induced by chromate exposure, a longitudinal cohort study including 515 workers with 918 measurements across 2010–2017 was c ...
lungfunction, etc ; air; air pollution; alleles; mortality; nitrogen dioxide; particulates; respiratory tract diseases; risk; Show all 9 Subjects
Abstract:
... Impaired lung function is predictive of mortality and is a key component of chronic obstructive pulmonary disease. Lung function has a strong genetic component but is also affected by environmental factors such as increased exposure to air pollution, but the effect of their interactions is not well understood.To identify interactions between genetic variants and air pollution measures which affect ...
lungfunction, etc ; COVID-19 infection; Human alphaherpesvirus 1; cumulative risk; intravenous injection; mortality; pneumonia; Show all 7 Subjects
Abstract:
... Reactivation of herpes simplex virus type 1 (HSV-1) has been described in critically ill patients with coronavirus disease 2019 (COVID-19) pneumonia. In the present two-center retrospective experience, we primarily aimed to assess the cumulative risk of HSV-1 reactivation detected on bronchoalveolar fluid (BALF) samples in invasively ventilated COVID-19 patients with worsening respiratory function ...
lungfunction, etc ; air pollution; alcohols; blood; blood pressure; microRNA; respiratory tract diseases; risk factors; Show all 8 Subjects
Abstract:
... Ambient particulate air pollution is a risk factor for cardiovascular and respiratory disease, yet the biological mechanisms underlying this association are not well understood. The current study aimed to investigate the mediation role of microRNAs on the association between personal PM₂.₅ exposure and blood pressure and lung function. One hundred and twenty adults (60 truck drivers and 60 office ...
lungfunction, etc ; air; analgesia; anesthesia; anesthetics; blood; gas exchange; oxygen; stifle; surgery; tidal volume; Show all 11 Subjects
Abstract:
... To compare the effects of fraction of inspired oxygen (FiO₂) with the addition of positive end-expiratory pressure (PEEP) during anesthesia on arterial oxygenation in the first 4 postoperative hours in dogs. We hypothesized that compared with dogs breathing FiO₂ ≥ 0.95 and no PEEP (ZEEP), the use of intraoperative PEEP would improve postoperative oxygenation, and that the use of PEEP combined with ...
lungfunction, etc ; asthma; docosahexaenoic acid; eicosapentaenoic acid; fever; inflammation; nose; omega-3 fatty acids; Show all 8 Subjects
Abstract:
... Respiratory diseases include a wide range of pathologies with different clinical manifestations, affecting the normal airways and lung function. An increase in the inflammatory response is considered a characteristic hallmark of these diseases, being also a critical factor for their progression. The n-3 polyunsaturated fatty acids (n-3 PUFAs) eicosapentaenoic acid (C20:4n-3, EPA), docosahexaenoic ...