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1. Employing the forced oscillation technique for the assessment of respiratory mechanics in adults

Author:
Qian Wei; Desai Avani; Therkorn Jennifer H.; Klein-Adams Jacquelyn C.; Sotolongo Anays M.; Falvo Michael J.
Source:
Journal of visualized experiments 2022 no.180 pp. e63165
ISSN:
1940-087X
Subject:
lung function,   etc   ; energy; mechanics; respiratory system;     Show all 4 Subjects
Abstract:
... There is increasing interest in the use of the forced oscillation technique (FOT) or oscillometry to characterize respiratory mechanics in healthy and diseased individuals. FOT, a complementary method to traditional pulmonary function testing, utilizes a range of oscillatory frequencies superimposed on tidal breathing to measure the functional relationship between airway pressure and flow. This pa ...
DOI:
10.3791/63165

2. Conducting respiratory oscillometry in an outpatient setting

Author:
Chang Ehren; Vasileva Anastasiia; Nohra Cynthia; Ryan Clodagh M.; Chow Chung-Wai; Yan Wu Joyce Ka
Source:
Journal of visualized experiments 2022 no.182 pp. e63243
ISSN:
1940-087X
Subject:
lung function,   etc   ; cognition; patients; quality control;     Show all 4 Subjects
Abstract:
... Respiratory oscillometry is a different modality of pulmonary function testing that is increasingly used in a clinical and research setting to provide information regarding lung mechanics. Respiratory oscillometry is conducted through three acceptable measurements of tidal breathing and can be performed with minimal contraindications. Young children and patients who cannot perform spirometry due t ...
DOI:
10.3791/63243

3. Heritability Analyses Uncover Shared Genetic Effects of Lung Function and Change over Time

Author:
Donghe Li; Woojin Kim; Jahoon An; Soriul Kim; Seungku Lee; Ahra Do; Wonji Kim; Sanghun Lee; Dankyu Yoon; Kwangbae Lee; Seounguk Ha; Edwin K. Silverman; Michael Cho; Chol Shin; Sungho Won
Source:
Genes 2022 v.13 no.7 pp. -
ISSN:
2073-4425
Subject:
lung function,   etc   ; heritability; lungs; single nucleotide polymorphism;     Show all 4 Subjects
Abstract:
... Genetic influence on lung functions has been identified in previous studies; however, the relative longitudinal effects of genetic factors and their interactions with smoking on lung function remain unclear. Here, we identified the longitudinal effects of genetic variants on lung function by determining single nucleotide polymorphism (SNP) heritability and genetic correlations, and by analyzing in ...
DOI:
10.3390/genes13071261

4. Personal PM2.5-bound PAH exposure, oxidative stress and lung function: The associations and mediation effects in healthy young adults

Author:
Lei Zhang; Hongwei Wang; Ze Yang; Bo Fang; Hao Zeng; Chunyan Meng; Suying Rong; Qian Wang
Source:
Environmental pollution 2022 v.293 pp. 118493
ISSN:
0269-7491
Subject:
lung function,   etc   ; models; oxidative stress; particulates; pollution;     Show all 5 Subjects
Abstract:
... Decreased lung function is an early hazard of respiratory damage from fine particulate matter (PM₂.₅) exposure. Limited studies have explored the association between PM₂.₅-bound polycyclic aromatic hydrocarbons (PAHs) and lung function, but studies at the personal level in healthy young adults are scarce. Here, we assessed personal PM₂.₅ and PM₂.₅-bound PAH levels in a panel of 45 healthy young ad ...
DOI:
10.1016/j.envpol.2021.118493

5. Cold temperature and sudden temperature drop as novel risk factors of asthma exacerbation: a longitudinal study in 18 Chinese cities

Author:
Yixiang Zhu; Ting Yang; Suijie Huang; Huichu Li; Jian Lei; Xiaowei Xue; Ya Gao; Yixuan Jiang; Cong Liu; Haidong Kan; Renjie Chen
Source:
Science of the total environment 2022 v.814 pp. 151959
ISSN:
0048-9697
Subject:
lung function,   etc   ; adults; ambient temperature; asthma; cold; longitudinal studies;     Show all 6 Subjects
Abstract:
... Few studies have explored the role of ambient temperature in asthma exacerbation. We aimed to explore the association of temperature with diurnal peak expiratory flow (PEF) variation and asthma exacerbation. We developed a longitudinal study among asthmatic adults in 18 Chinese cities. Subjects recorded PEF in dynamic pulmonary function monitoring from 2017 to 2020. Linear mixed-effect model and g ...
DOI:
10.1016/j.scitotenv.2021.151959

6. Imaging-guided bioreactor for generating bioengineered airway tissue

Author:
Mir Seyed Mohammad; Chen Jiawen; Pinezich Meghan R.; O’Neill John D.; Guenthart Brandon A.; Vunjak-Novakovic Gordana; Kim Jinho
Source:
Journal of visualized experiments 2022 no.182 pp. e63544
ISSN:
1940-087X
Subject:
lung function,   etc   ; bioreactors; medicine; rats; respiratory tract diseases; ultrastructure;     Show all 6 Subjects
Abstract:
... Repeated injury to airway tissue can impair lung function and cause chronic lung disease, such as chronic obstructive pulmonary disease. Advances in regenerative medicine and bioreactor technologies offer opportunities to produce lab-grown functional tissue and organ constructs that can be used to screen drugs, model disease, and engineer tissue replacements. Here, a miniaturized bioreactor couple ...
DOI:
10.3791/63544

7. Health effects in people relocating between environments of differing ambient air pollution concentrations: A literature review

Author:
Leslie Edwards; Paul Wilkinson; Gemma Rutter; Ai Milojevic
Source:
Environmental pollution 2022 v.292 pp. 118314
ISSN:
0269-7491
Subject:
lung function,   etc   ; adolescence; air; air pollution; biomarkers; mortality; people; pregnancy outcome;     Show all 8 Subjects
Abstract:
... People who relocate to a new environment may experience health effects from a change in ambient air pollution. We undertook a literature review of studies of such relocations and health effects and report the results as a narrative analysis. Fifteen articles of heterogeneous designs met the inclusion criteria. Four short-term (relocation duration less than six months) and three long-term (relocati ...
DOI:
10.1016/j.envpol.2021.118314

8. Transferring from moisture damaged school building to clean facilities – The avoidance of mold exposure induces a decline in symptoms and improvement in lung function among personnel

Author:
Liisa Vilén; Marja Päivinen; Janne Atosuo; Tuula Putus
Source:
Environmental research 2022 v.212 pp. 113598
ISSN:
0013-9351
Subject:
lung function,   etc   ; air; case studies; human resources; lungs; nitric oxide; research;     Show all 7 Subjects
Abstract:
... Working in a moisture-damaged building can cause different symptoms and effects on lung functions. Moving to a clean environment, it is believed to reduce symptoms and alleviate potential adverse health effects. This case study monitors the health effects of personnel in one school building before and after all school activities were transferred from a moisture-damaged school building to clean pre ...
DOI:
10.1016/j.envres.2022.113598

9. An archetypal model of a breathable air-circuit in an electro-pneumatic ventilator device

Author:
Ebenezer Olubunmi Ige; Adedotun Adetunla; Samuel Olufemi Amudipe; Adeyinka Adeoye; Matthew Glucksberg
Source:
Heliyon 2022 v.8 no.5 pp. e09378
ISSN:
2405-8440
Subject:
lung function,   etc   ; COVID-19 infection; air; medicine; models; patients; tidal volume;     Show all 7 Subjects
Abstract:
... Mechanical ventilator is a machine that is mechanically designed to deliver breathable air in and out of the lungs to provide a breathing mechanism for a patient who is physically unable to breathe, it is an indispensable life-support device in critical care medicine and medical emergencies such as scenarios during the COVID-19 pandemic. This research presents a model design of the pneumatic circu ...
DOI:
10.1016/j.heliyon.2022.e09378

10. The proteasome-dependent degradation of ALKBH5 regulates ECM deposition in PM2.5 exposure-induced pulmonary fibrosis of mice

Author:
Yaling Zhang; Qingping Liu; Jie Ning; Tao Jiang; Aijuan Kang; Lipeng Li; Yaxian Pang; Boyuan Zhang; XiaoYan Huang; Qian Wang; Lei Bao; Yujie Niu; Rong Zhang
Source:
Journal of hazardous materials 2022 v.432 pp. 128655
ISSN:
0304-3894
Subject:
lung function,   etc   ; breathing; lungs; microRNA; particulates; proteasome endopeptidase complex; pulmonary fibrosis;     Show all 7 Subjects
Abstract:
... Long-term inhalation of fine particulate matter (PM₂.₅) can cause serious effects on the respiratory system. It might be attributed to the fact that PM₂.₅ could directly enter and deposit in lung tissues. We established models of PM₂.₅ exposure in vivo and in vitro to explore the adverse effects of ambient PM₂.₅ on pulmonary and its potential pathogenic mechanisms. Our results showed that PM₂.₅ ex ...
DOI:
10.1016/j.jhazmat.2022.128655

11. Impact of Obesity on Lung Function in Cats with Bronchoconstriction

Author:
Alicia Caro-Vadillo; J. Alberto Montoya-Alonso; Laín García-Guasch
Source:
Veterinary sciences 2022 v.9 no.6 pp. -
ISSN:
2306-7381
Subject:
lung function,   etc   ; adults; body condition; bronchoconstriction; males; obesity; plethysmography; risk; tidal volume;     Show all 9 Subjects
Abstract:
... Obesity is a nutritional disorder commonly diagnosed in adult cats that has been associated with an increased risk of different chronic diseases including respiratory diseases. The main objective of this study is to define if there is a relation between lung function measured by barometric whole-body plethysmography and obesity in cats with bronchoconstriction. Fifty-three cats were included in th ...
DOI:
10.3390/vetsci9060278

12. Structural and functional alterations of subjects with cement dust exposure: A longitudinal quantitative computed tomography-based study

Author:
Taewoo Kim; Myoung-nam Lim; Woo Jin Kim; Thao Thi Ho; Chang Hyun Lee; Kum Ju Chae; So Hyeon Bak; Gong Yong Jin; Eun-Kee Park; Sanghun Choi
Source:
Science of the total environment 2022 v.837 pp. 155812
ISSN:
0048-9697
Subject:
lung function,   etc   ; air; cement; computed tomography; dust; environment; pulmonary emphysema; risk factors;     Show all 8 Subjects
Abstract:
... Cement dust exposure (CDE) can be a risk factor for pulmonary disease, causing changes in segmental airways and parenchymal lungs. This study investigates longitudinal alterations in quantitative computed tomography (CT)-based metrics due to CDE. We obtained CT-based airway structural and lung functional metrics from CDE subjects with baseline CT and follow-up CT scans performed three years later. ...
DOI:
10.1016/j.scitotenv.2022.155812

13. Large-Scale Hypothesis Testing for Causal Mediation Effects with Applications in Genome-wide Epigenetic Studies

Author:
Zhonghua Liu; Jincheng Shen; Richard Barfield; Joel Schwartz; Andrea A. Baccarelli; Xihong Lin
Source:
Journal of the American Statistical Association 2022 v.117 no.537 pp. 67-81
ISSN:
1537-274X
Subject:
lung function,   etc   ; DNA; DNA methylation; cohort studies; epigenetics; epigenome; normal distribution; statistical inference;     Show all 8 Subjects
Abstract:
... In genome-wide epigenetic studies, it is of great scientific interest to assess whether the effect of an exposure on a clinical outcome is mediated through DNA methylations. However, statistical inference for causal mediation effects is challenged by the fact that one needs to test a large number of composite null hypotheses across the whole epigenome. Two popular tests, the Wald-type Sobel’s test ...
DOI:
10.1080/01621459.2021.1914634

14. sJIVE: Supervised joint and individual variation explained

Author:
Elise F. Palzer; Christine H. Wendt; Russell P. Bowler; Craig P. Hersh; Sandra E. Safo; Eric F. Lock
Source:
Computational statistics & data analysis 2022 v.175 pp. 107547
ISSN:
0167-9473
Subject:
lung function,   etc   ; biomedical research; data analysis; data collection; gene expression; models; proteomics; statistics;     Show all 8 Subjects
Abstract:
... Analyzing multi-source data, which are multiple views of data on the same subjects, has become increasingly common in molecular biomedical research. Recent methods have sought to uncover underlying structure and relationships within and/or between the data sources, and other methods have sought to build a predictive model for an outcome using all sources. However, existing methods that do both are ...
DOI:
10.1016/j.csda.2022.107547

15. Lung function assessment and its association with blood chromium in a chromate exposed population

Author:
Yali Zhang; Zekang Su; Guiping Hu; Shiyi Hong; Changmao Long; Qiaojian Zhang; Pai Zheng; Tiancheng Wang; Shanfa Yu; Fang Yuan; Xiaojun Zhu; Guang Jia
Source:
Science of the total environment 2022 v.818 pp. 151741
ISSN:
0048-9697
Subject:
lung function,   etc   ; adverse effects; atomic absorption spectrometry; chromates; chromium; cohort studies; environment; monitoring;     Show all 8 Subjects
Abstract:
... Hexavalent chromium [Cr(VI)] and its compounds have been associated with various respiratory diseases, while few studies have attempted to determine its adverse effect on lung function. To explore the potential early indicators of health surveillance for respiratory diseases induced by chromate exposure, a longitudinal cohort study including 515 workers with 918 measurements across 2010–2017 was c ...
DOI:
10.1016/j.scitotenv.2021.151741

16. Genome-wide gene-air pollution interaction analysis of lung function in 300,000 individuals

Author:
Carl A. Melbourne; A. Mesut Erzurumluoglu; Nick Shrine; Jing Chen; Martin D. Tobin; Anna L. Hansell; Louise V. Wain
Source:
Environment international 2022 v.159 pp. 107041
ISSN:
0160-4120
Subject:
lung function,   etc   ; air; air pollution; alleles; mortality; nitrogen dioxide; particulates; respiratory tract diseases; risk;     Show all 9 Subjects
Abstract:
... Impaired lung function is predictive of mortality and is a key component of chronic obstructive pulmonary disease. Lung function has a strong genetic component but is also affected by environmental factors such as increased exposure to air pollution, but the effect of their interactions is not well understood.To identify interactions between genetic variants and air pollution measures which affect ...
DOI:
10.1016/j.envint.2021.107041

17. Reactivation of Herpes Simplex Virus Type 1 (HSV-1) Detected on Bronchoalveolar Lavage Fluid (BALF) Samples in Critically Ill COVID-19 Patients Undergoing Invasive Mechanical Ventilation: Preliminary Results from Two Italian Centers

Author:
Daniele Roberto Giacobbe; Stefano Di Bella; Silvia Dettori; Giorgia Brucci; Verena Zerbato; Riccardo Pol; Ludovica Segat; Pierlanfranco D’Agaro; Erik Roman-Pognuz; Federica Friso; Luigi Principe; Umberto Lucangelo; Lorenzo Ball; Chiara Robba; Denise Battaglini; Andrea De Maria; Iole Brunetti; Nicolò Patroniti; Federica Briano; Bianca Bruzzone; Giulia Guarona; Laura Magnasco; Chiara Dentone; Giancarlo Icardi; Paolo Pelosi; Roberto Luzzati; Matteo Bassetti
Source:
Microorganisms 2022 v.10 no.2 pp. -
ISSN:
2076-2607
Subject:
lung function,   etc   ; COVID-19 infection; Human alphaherpesvirus 1; cumulative risk; intravenous injection; mortality; pneumonia;     Show all 7 Subjects
Abstract:
... Reactivation of herpes simplex virus type 1 (HSV-1) has been described in critically ill patients with coronavirus disease 2019 (COVID-19) pneumonia. In the present two-center retrospective experience, we primarily aimed to assess the cumulative risk of HSV-1 reactivation detected on bronchoalveolar fluid (BALF) samples in invasively ventilated COVID-19 patients with worsening respiratory function ...
DOI:
10.3390/microorganisms10020362

18. Short-term ambient particulate air pollution exposure, microRNAs, blood pressure and lung function

Author:
Xiaowei Cong; Juan Zhang; Rongli Sun; Yuepu Pu
Source:
Environmental pollution 2022 v.292 pp. 118387
ISSN:
0269-7491
Subject:
lung function,   etc   ; air pollution; alcohols; blood; blood pressure; microRNA; respiratory tract diseases; risk factors;     Show all 8 Subjects
Abstract:
... Ambient particulate air pollution is a risk factor for cardiovascular and respiratory disease, yet the biological mechanisms underlying this association are not well understood. The current study aimed to investigate the mediation role of microRNAs on the association between personal PM₂.₅ exposure and blood pressure and lung function. One hundred and twenty adults (60 truck drivers and 60 office ...
DOI:
10.1016/j.envpol.2021.118387

19. Effects of intraoperative positive end-expiratory pressure and fraction of inspired oxygen on postoperative oxygenation in dogs undergoing stifle surgery

Author:
Manuel Martin-Flores; Joaquin D. Araos; Zoe S. Daniels; Ashley Newman; Sarah A. Nugen; Luis Campoy
Source:
Veterinary anaesthesia and analgesia 2022 v.49 no.3 pp. 275-281
ISSN:
1467-2987
Subject:
lung function,   etc   ; air; analgesia; anesthesia; anesthetics; blood; gas exchange; oxygen; stifle; surgery; tidal volume;     Show all 11 Subjects
Abstract:
... To compare the effects of fraction of inspired oxygen (FiO₂) with the addition of positive end-expiratory pressure (PEEP) during anesthesia on arterial oxygenation in the first 4 postoperative hours in dogs. We hypothesized that compared with dogs breathing FiO₂ ≥ 0.95 and no PEEP (ZEEP), the use of intraoperative PEEP would improve postoperative oxygenation, and that the use of PEEP combined with ...
DOI:
10.1016/j.vaa.2022.02.002

20. N-3 PUFAs and their specialized pro-resolving lipid mediators on airway inflammatory response: beneficial effects in the prevention and treatment of respiratory diseases

Author:
Jessica Zúñiga-Hernández; Verónica Sambra; Francisca Echeverría; Luis A. Videla; Rodrigo Valenzuela
Source:
Food & function 2022 v.13 no.8 pp. 4260-4272
ISSN:
2042-650X
Subject:
lung function,   etc   ; asthma; docosahexaenoic acid; eicosapentaenoic acid; fever; inflammation; nose; omega-3 fatty acids;     Show all 8 Subjects
Abstract:
... Respiratory diseases include a wide range of pathologies with different clinical manifestations, affecting the normal airways and lung function. An increase in the inflammatory response is considered a characteristic hallmark of these diseases, being also a critical factor for their progression. The n-3 polyunsaturated fatty acids (n-3 PUFAs) eicosapentaenoic acid (C20:4n-3, EPA), docosahexaenoic ...
DOI:
10.1039/d1fo03551g