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1. The miRNA‐149‐5p/MyD88 axis is responsible for ursolic acid‐mediated attenuation of the stemness and chemoresistance of non‐small cell lung cancer cells

Author:
Chen, Quanfang; Luo, Jin; Wu, Cong; Lu, Huasong; Cai, Shuangqi; Bao, Chongxi; Liu, Dongmei; Kong, Jinliang
Source:
Environmental toxicology 2020 v.35 no.5 pp. 561-569
ISSN:
1520-4081
Subject:
lung neoplasms,   etc   ; neoplasm cells; paclitaxel; ursolic acid;     Show all 4 Subjects
Abstract:
... Although the inhibitory roles of ursolic acid (UA) have been established in various tumors, its effects on the stemness of non‐small cell lung cancer (NSCLC) cells are still unclear. Here, we constructed NSCLC cells with paclitaxel resistance (A549‐PR) and showed that A549‐PR exhibited a remarkably stronger stemness than the parental A549 cells, which is evident by the increase of spheroid formati ...
DOI:
10.1002/tox.22891

2. Study on the activity and mechanism of skimmianine against human non-small cell lung cancer

Author:
Zuo, Yangsong; Pu, Juan; Chen, Guiming; Shen, Wenyi; Wang, Baoran
Source:
Natural product research 2019 v.33 no.5 pp. 759-762
ISSN:
1478-6427
Subject:
lung neoplasms,   etc   ; apoptosis; humans;     Show all 3 Subjects
Abstract:
... The present research was to investigate the effects of skimmianine (SK) in four non-small cell lung cancer (NSCLC) cells. We found that SK can significantly inhibit the growth of NSCLC cells and markedly induce apoptosis in NSCLC cells. The effects of growth inhibition and apoptosis induction were in a concentration–response relationship and caspase-dependent manner. ...
DOI:
10.1080/14786419.2017.1408096

3. RBM38 induces SIRT1 expression during hypoxia in non-small cell lung cancer cells by suppressing MIR34A expression

Author:
Lin, Qing-yan; Yin, Hong-lei
Source:
Biotechnology letters 2020 v.42 no.1 pp. 35-44
ISSN:
0141-5492
Subject:
lung neoplasms,   etc   ; data collection; genes; genomics; hypoxia; neoplasm cells; patients;     Show all 7 Subjects
Abstract:
... OBJECTIVE: The study is to research how miR-34-SIRT1 is regulated during hypoxia in lung cancer cells. RESULTS: Analysis of publicly available datasets from patients with NSCLC did not reveal significant genomic alterations in RBM38, SIRT1, HIF1A, MIR34A, MIR34B, and MIR34C, but expectedly revealed alterations in TP53. Overall survival in NSCLC patients with or without alterations in these genes w ...
DOI:
10.1007/s10529-019-02766-3

4. Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) in non-small cell lung cancer

Author:
Zeng, Zhi; Wang, Zi-yao; Li, Yu-kun; Ye, Dong-mei; Zeng, Juan; Hu, Jia-li; Chen, Pi-feng; Xiao, Jiao; Zou, Juan; Li, Zhen-hua
Source:
Life sciences 2020 v.254 pp. 117325
ISSN:
0024-3205
Subject:
lung neoplasms,   etc   ; carcinogenesis; chemical structure; drug therapy; gene expression; prognosis; transcription factors;     Show all 7 Subjects
Abstract:
... Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor that can regulate downstream target gene expression. Kelch-like ECH-associated protein 1 (Keap1) negatively regulates Nrf2 activation and translocation to target its 26S proteasomal degradation. It has been widely reported that the Keap1/Nrf2 pathway is associated with tumorigenesis, chemotherapy resistance and pr ...
DOI:
10.1016/j.lfs.2020.117325

5. Long noncoding RNA LCTS5 inhibits non-small cell lung cancer by interacting with INO80

Author:
Wang, Baozhong; Wang, Yanwen; Ma, Dan; Wang, Liping; Yang, Mengxiang
Source:
Life sciences 2020 v.253 pp. 117680
ISSN:
0024-3205
Subject:
lung neoplasms,   etc   ; genes; non-coding RNA; small interfering RNA; therapeutics; viability;     Show all 6 Subjects
Abstract:
... To investigate the effect of lncRNA LCTS5 in the non-small cell lung cancer (NSCLC).LncRNA profiling was used to identify the novel lncRNA LCTS5. Viability and migration assays were implemented to evaluate the in vitro effect of LCTS5. Transplantation study was designed to investigate the in vivo role. Short hairpin RNA (shRNA) and lentiviral vector were used to alter LCTS5 expression.We identifie ...
DOI:
10.1016/j.lfs.2020.117680

6. A novel chimeric PD1-NKG2D-41BB receptor enhances antitumor activity of NK92 cells against human lung cancer H1299 cells by triggering pyroptosis

Author:
Lu, Chengui; Guo, Changjiang; Chen, Han; Zhang, Huiyong; Zhi, Lingtong; Lv, Tanyu; Li, Mingfeng; Niu, Zhiyuan; Lu, Ping; Zhu, Wuling
Source:
Molecular immunology 2020 v.122 pp. 200-206
ISSN:
0161-5890
Subject:
lung neoplasms,   etc   ; antigens; antineoplastic activity; human diseases; immunotherapy; models; natural killer cells; neoplasm cells; pyroptosis; receptors;     Show all 10 Subjects
Abstract:
... Chimeric antigen receptor (CAR)-modified adoptive natural killer (NK) cells represent a promising immunotherapeutic modality for cancer treatment but face many challenges in solid tumors. One major obstacle is the immune-suppressive effects induced by inhibitory receptors (IR) including PD1. To interfere with PD1 signaling to augment CAR-NK cells’ activity against solid tumors, we rationally desig ...
DOI:
10.1016/j.molimm.2020.04.016

7. Glutathione-responsive biodegradable polyurethane nanoparticles for lung cancer treatment

Author:
Iyer, Roshni; Nguyen, Tam; Padanilam, Dona; Xu, Cancan; Saha, Debabrata; Nguyen, Kytai T.; Hong, Yi
Source:
Journal of controlled release 2020 v.321 pp. 363-371
ISSN:
0168-3659
Subject:
lung neoplasms,   etc   ; biodegradability; cisplatin; disulfide bonds; drug therapy; emulsions; glutathione; models; nanoparticles; neoplasm cells; polyurethanes; solvents;     Show all 12 Subjects
Abstract:
... Lung cancer is one of the major causes of cancer-related deaths worldwide. Stimuli-responsive polymers and nanoparticles, which respond to exogenous or endogenous stimuli in the tumor microenvironment, have been widely investigated for spatiotemporal chemotherapeutic drug release applications for cancer chemotherapy. We developed glutathione (GSH)-responsive polyurethane nanoparticles (GPUs) using ...
DOI:
10.1016/j.jconrel.2020.02.021

8. LncRNA MIR4435‐2HG‐mediated upregulation of TGF‐β1 promotes migration and proliferation of nonsmall cell lung cancer cells

Author:
Yang, Mei; He, Xiaohua; Huang, Xiaoxian; Wang, Jiyang; He, Yuxin; Wei, Li
Source:
Environmental toxicology 2020 v.35 no.5 pp. 582-590
ISSN:
1520-4081
Subject:
lung neoplasms,   etc   ; microRNA; neoplasm cells; neoplasm progression; non-coding RNA; transcriptomics; transforming growth factor beta 1;     Show all 7 Subjects
Abstract:
... The roles of long noncoding RNAs (lncRNAs) have been shown to play critical roles in tumor progression. Here, it was identified that lncRNA MIR4435‐2HG was highly expressed in lung cancer tissues, especially in nonsmall cell lung cancer (NSCLC). A consistent result was obtained in lung cancer cells. Functional experiments showed that knockdown of MIR4435‐2HG reduced the proliferation and migration ...
DOI:
10.1002/tox.22893

9. High-sensitive and multiplex biosensing assay of NSCLC-derived exosomes via different recognition sites based on SPRi array

Author:
Fan, Yunpeng; Duan, Xiaolei; Zhao, Min; Wei, Xiaotong; Wu, Jiangling; Chen, Wenqin; Liu, Ping; Cheng, Wei; Cheng, Quan; Ding, Shijia
Source:
Biosensors & bioelectronics 2020 v.154 pp. 112066
ISSN:
0956-5663
Subject:
lung neoplasms,   etc   ; antibodies; biomarkers; biosensors; blood; detection limit; exosomes; high-throughput screening methods; lungs; nanogold; screening;     Show all 11 Subjects
Abstract:
... Non-small cell lung cancer (NSCLC) have been reported to secret a high concentration of exosomes into blood circulatory system, which is one of sensitive and non-invasive biomarkers for NSCLC's early-stage diagnosis. But it is still lack of feasible and accurate methods to analyze the different NSCLC cells-derived exosomes. Herein, we built a SPRi biosensing assay for high-sensitive and multiplex ...
DOI:
10.1016/j.bios.2020.112066

10. Development of a lateral flow aptamer assay strip for facile identification of theranostic exosomes isolated from human lung carcinoma cells

Author:
Yu, Qiang; Zhao, Qu; Wang, Sai; Zhao, Shuai; Zhang, Shan; Yin, Yingai; Dong, Yiyang
Source:
Analytical biochemistry 2020 v.594 pp. 113591
ISSN:
0003-2697
Subject:
lung neoplasms,   etc   ; exosomes; human diseases; nanogold; neoplasm cells; oligonucleotides; surface proteins;     Show all 7 Subjects
Abstract:
... Exosomes are Extracellular Vesicles (EV) that own unique structural features and functions and have gradually become the hot research spot in recent years. The tumor-derived exosomes contain various types of useful biological information, and medical identification of exosomes relied on the specific characterization of membrane surface proteins. In this study, in order to rapidly identify non-smal ...
DOI:
10.1016/j.ab.2020.113591

11. Fine particulate air pollution and human mortality: 25+ years of cohort studies

Author:
Pope, C. Arden; Coleman, Nathan; Pond, Zachari A.; Burnett, Richard T.
Source:
Environmental research 2020 v.183 pp. 108924
ISSN:
0013-9351
Subject:
lung neoplasms,   etc   ; air pollution; chronic exposure; cohort studies; humans; mortality; particulates; risk;     Show all 8 Subjects
Abstract:
... Much of the key epidemiological evidence that long-term exposure to fine particulate matter air pollution (PM₂.₅) contributes to increased risk of mortality comes from survival studies of cohorts of individuals. Although the first two of these studies, published in the mid-1990s, were highly controversial, much has changed in the last 25 + years. The objectives of this paper are to succinctly comp ...
DOI:
10.1016/j.envres.2019.108924

12. α₃β₁ Integrin-Targeting Polymersomal Docetaxel as an Advanced Nanotherapeutic for Nonsmall Cell Lung Cancer Treatment

Author:
Zou, Yan; Sun, Yinping; Guo, Beibei; Wei, Yaohua; Xia, Yifeng; Huangfu, Zhenyuan; Meng, Fenghua; van Hest, Jan C. M.; Yuan, Jiandong; Zhong, Zhiyuan
Source:
ACS applied materials & interfaces 2020 v.12 no.13 pp. 14905-14913
ISSN:
1944-8252
Subject:
lung neoplasms,   etc   ; adverse effects; antineoplastic activity; cytotoxicity; human diseases; integrins; mice; neoplasm cells; neurotoxicity; patients;     Show all 10 Subjects
Abstract:
... Docetaxel (DTX) widely used for treating nonsmall cell lung cancer (NSCLC) patients is associated with dose-limiting side effects, especially neurotoxicity and myelosuppression. Here, we have developed cyclic cNGQGEQc peptide-directed polymersomal docetaxel (cNGQ-PS-DTX) as a targeted and multifunctional formulation for NSCLC. cNGQ-PS-DTX carrying 8.1 wt % DTX had a size of 93 nm, neutral surface ...
DOI:
10.1021/acsami.0c01069

13. Exosomal miR-106b serves as a novel marker for lung cancer and promotes cancer metastasis via targeting PTEN

Author:
Sun, Shifang; Chen, Hailin; Xu, Chenlei; Zhang, Yun; Zhang, Qiaoli; Chen, Lei; Ding, Qunli; Deng, Zaichun
Source:
Life sciences 2020 v.244 pp. 117297
ISSN:
0024-3205
Subject:
lung neoplasms,   etc   ; biomarkers; blood serum; cell movement; lymph nodes; metastasis; microRNA; neoplasm cells; patients; volunteers;     Show all 10 Subjects
Abstract:
... As novel non-invasive tumor diagnostic biomarkers, exosomal bioactive miRNAs have received increasing attention. Herein, the aim of this study is to explore the clinical values and roles of exosomal miR106b in lung cancer. The exosomal miR-106b level was much higher in the serum of patients with lung cancer than that in healthy volunteers. Also, the exosomal miR-106b level in the lung cancer patie ...
DOI:
10.1016/j.lfs.2020.117297

14. The Antibody-Free Recognition of Cancer Cells Using Plasmonic Biosensor Platforms with the Anisotropic Resonant Metasurfaces

Author:
Zhang, Zhang; Yang, Maosheng; Yan, Xin; Guo, Xinyue; Li, Jie; Yang, Yue; Wei, Dequan; Liu, Longhai; Xie, Jianhua; Liu, Yufei; Liang, Lanju; Yao, Jianquan
Source:
ACS applied materials & interfaces 2020 v.12 no.10 pp. 11388-11396
ISSN:
1944-8252
Subject:
lung neoplasms,   etc   ; anisotropy; antibodies; biosensors; labeling techniques; liver neoplasms; neoplasm cells; quantitative analysis; radar; staining; wavelet;     Show all 11 Subjects
Abstract:
... It is vital and promising for portable and disposable biosensing devices to achieve on-site detection and analysis of cancer cells. Although traditional labeling techniques provide an accurate quantitative measurement, the complicated cell staining and high-cost measurements limit their further development. Here, we demonstrate a nonimmune biosensing technology. The plasmonic biosensors, which are ...
DOI:
10.1021/acsami.0c00095

15. Quantification and Single-Base Resolution Analysis of N1-Methyladenosine in mRNA by Ligation-Assisted Differentiation

Author:
Ding, Jiang-Hui; Ma, Cheng-Jie; Chen, Meng-Yuan; Chen, Bei; Yuan, Bi-Feng; Feng, Yu-Qi
Source:
Analytical chemistry 2020 v.92 no.3 pp. 2612-2619
ISSN:
1520-6882
Subject:
lung neoplasms,   etc   ; DNA; adenosine; carcinogenesis; ligases; messenger RNA; moieties; proteins; quantitative polymerase chain reaction; tissues; uridine;     Show all 11 Subjects
Abstract:
... RNA modification, such as N1-methyladenosine (m¹A), affects the secondary structure of RNA and its ability to recognize specific reader proteins. Methods for detecting site-specific m¹A are in demand. We report here a ligation-assisted differentiation approach for quantitative detection of m¹A in mRNA with single-base resolution. The methyl group in m¹A disrupts the Watson–Crick base pairing with ...
DOI:
10.1021/acs.analchem.9b04454

16. Dynamically Monitoring the Clonal Evolution of Lung Cancer Based on the Molecular Characterization of Circulating Tumor Cells Using Aptamer Cocktail-Modified Nanosubstrates

Author:
Zhu, Ying; Zou, Chang; Zhang, Jian; Jiang, Wenting; Guan, Fanglin; Tang, Kejing; Li, Shuhua; Li, Guannan; Wang, Jianhong; Ke, Zunfu
Source:
ACS applied materials & interfaces 2020 v.12 no.5 pp. 5671-5679
ISSN:
1944-8252
Subject:
lung neoplasms,   etc   ; histology; metastasis; monitoring; neoplasm cells; oligonucleotides; patients; phenotype; therapeutics;     Show all 9 Subjects
Abstract:
... Dynamically monitoring the clonal evolution of lung cancer and performing molecular analyses on tumor cells are challenging but necessary tasks to adjust therapeutic interventions and evaluate treatment efficacy. Circulating tumor cells (CTCs), as a “liquid biopsy”, may offer an auxiliary tool to identify phenotypic transformation of solid tumors at primary or metastatic sites and uncover their co ...
DOI:
10.1021/acsami.9b22234

17. Phase II Trial of Epigallocatechin-3-Gallate in Acute Radiation-Induced Esophagitis for Esophagus Cancer

Author:
Li, Xiaoling; Xing, Ligang; Zhang, Yujun; Xie, Peng; Zhu, Wanqi; Meng, Xiangjiao; Wang, Yinxia; Kong, Lingling; Zhao, Hanxi; Yu, Jinming
Source:
Journal of medicinal food 2020 v.23 no.1 pp. 43-49
ISSN:
1557-7600
Subject:
lung neoplasms,   etc   ; dysphagia; epigallocatechin gallate; esophageal neoplasms; hospitals; oral administration; pain; patients; radiotherapy; survival rate; China;     Show all 11 Subjects
Abstract:
... Acute radiation-induced esophagitis (ARIE) is among the most serious form of toxicities associated with definitive radiotherapy or chemoradiotherapy used for treatment of patients with esophageal cancer. Our preliminary phase I and II trials of lung cancer patients who received radiotherapy indicated epigallocatechin-3-gallate (EGCG) as a promising therapeutic option against ARIE. Therefore, we co ...
DOI:
10.1089/jmf.2019.4445

18. Rapid and sensitive exosome detection with CRISPR/Cas12a

Author:
Zhao, Xianxian; Zhang, Wenqing; Qiu, Xiaopei; Mei, Qiang; Luo, Yang; Fu, Weiling
Source:
Analytical and bioanalytical chemistry 2020 v.412 no.3 pp. 601-609
ISSN:
1618-2642
Subject:
lung neoplasms,   etc   ; exosomes; gene editing; membrane proteins; nanoparticles; nucleic acids; oligonucleotides; pathogenesis; patients; prognosis;     Show all 10 Subjects
Abstract:
... Numerous studies have shown that exosomes are closely related to the pathogenesis of various diseases, especially cancers. Therefore, a rapid and sensitive method for exosome detection will be of great importance for the diagnosis and prognosis of diseases. We report here a method for exosome detection based on the CD63 aptamer and clustered regular interspaced short palindromic repeats (CRISPR)/C ...
DOI:
10.1007/s00216-019-02211-4

19. Synthesized Derivatives of Aloe-Emodin as Proliferation Inhibitors for Human Breast Adenocarcinoma, Human Nonsmall Cell Lung Carcinoma, and Human Cervix Carcinoma

Author:
Chen, Chao; Cao, Tingting; Li, Yong; Hu, Yuegao; Yang, Hongjun; Yin, Shufan
Source:
Chemistry of natural compounds 2020 v.56 no.1 pp. 30-33
ISSN:
0009-3130
Subject:
lung neoplasms,   etc   ; Aloe vera; Rheum palmatum; adenocarcinoma; antineoplastic activity; breast neoplasms; breasts; cervix; human diseases; humans;     Show all 10 Subjects
Abstract:
... Aloe-emodin, which is isolated from Rheum palmatum L. and Aloe vera, has been proved to possess good antiproliferative activity. A series of Aloe-emodin derivatives were designed and synthesized; in addition, they were evaluated as inhibitors of proliferation of human breast adenocarcinoma (MDA-MB-231), human nonsmall cell lung carcinoma (A549), and human cervix carcinoma (HeLa) cells. The biologi ...
DOI:
10.1007/s10600-020-02937-z

20. Recent progress in structural studies on TMEM16A channel

Author:
Shi, Sai; Pang, Chunli; Guo, Shuai; Chen, Yafei; Ma, Biao; Qu, Chang; Ji, Qiushuang; An, Hailong
Source:
Computational and Structural Biotechnology Journal 2020 v.18 pp. 714-722
ISSN:
2001-0370
Subject:
lung neoplasms,   etc   ; calcium; chlorides; cystic fibrosis; drugs; hypertension; membrane potential; pain; permeability;     Show all 9 Subjects
Abstract:
... The calcium-activated chloride channel, also known as TMEM16A, shows both calcium and membrane potential dependent activation. The channel is expressed broadly and contributes to a variety of physiological processes, and it is expected to be a target for the treatment of diseases such as hypertension, pain, cystic fibrosis and lung cancer. A thorough understanding of the structural characteristics ...
DOI:
10.1016/j.csbj.2020.03.015
PubMed:
32257055
PubMed Central:
PMC7118279