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1. Efficient Estimation of Optimal Regimes Under a No Direct Effect Assumption

Author:
Liu, Lin; Shahn, Zach; Robins, James M.; Rotnitzky, Andrea
Source:
Journal of the American Statistical Association 2021 v.116 no.533 pp. 224-239
ISSN:
1537-274X
Subject:
lung neoplasms,   etc   ; models; patients;     Show all 3 Subjects
Abstract:
... We derive new estimators of an optimal joint testing and treatment regime under the no direct effect (NDE) assumption that a given laboratory, diagnostic, or screening test has no effect on a patient’s clinical outcomes except through the effect of the test results on the choice of treatment. We model the optimal joint strategy with an optimal structural nested mean model (opt-SNMM). The proposed ...
DOI:
10.1080/01621459.2020.1856117

2. Retraction: CircRNA PVT1 modulates cell metastasis via the miR-181a-5p/NEK7 axis and cisplatin chemoresistance through miR-181a-5p-mediated autophagy in non-small cell lung cancer

Author:
Fisher, Laura
Source:
RSC advances 2021 v.11 no.11 pp. 6256
ISSN:
2046-2069
Subject:
lung neoplasms,   etc   ; autophagy; cisplatin; metastasis;     Show all 4 Subjects
Abstract:
... Retraction of ‘CircRNA PVT1 modulates cell metastasis via the miR-181a-5p/NEK7 axis and cisplatin chemoresistance through miR-181a-5p-mediated autophagy in non-small cell lung cancer’ by Limin Yan et al., RSC Adv., 2019, 9, 42324–42334, DOI: 10.1039/C9RA08872E. ...
DOI:
10.1039/d1ra90075g

3. Harnessing affinity-based protein profiling to reveal a novel target of nintedanib

Author:
Chen, Xiong; Li, Menglin; Li, Manru; Wang, Dongmei; Zhang, Jinlan
Source:
Chemical communications 2021 v.57 no.25 pp. 3139-3142
ISSN:
1364-548X
Subject:
lung neoplasms,   etc   ; ; lungs; pulmonary fibrosis; therapeutics; tyrosine;     Show all 6 Subjects
Abstract:
... Nintedanib (BIBF1120), a triple angiokinase inhibitor, was first approved for idiopathic pulmonary fibrosis (IPF) therapy and is also efficacious for lung carcinoma, and interstitial lung diseases, far beyond its inhibition of VEGFR/PDGFR/FGFR. We identified tripeptidyl-peptidase 1 (TPP1) as one of the direct targets of nintedanib employing the affinity-based protein profiling (AfBPP) technique. T ...
DOI:
10.1039/d1cc00354b

4. Retraction: Long noncoding RNA ANRIL knockdown increases sensitivity of non-small cell lung cancer to cisplatin by regulating the miR-656-3p/SOX4 axis

Author:
Fisher, Laura
Source:
RSC advances 2021 v.11 no.11 pp. 6255
ISSN:
2046-2069
Subject:
lung neoplasms,   etc   ; cisplatin; non-coding RNA;     Show all 3 Subjects
Abstract:
... Retraction of ‘Long noncoding RNA ANRIL knockdown increases sensitivity of non-small cell lung cancer to cisplatin by regulating the miR-656-3p/SOX4 axis’ by Xianfang Wang et al., RSC Adv., 2019, 9, 38735–38744, DOI: 10.1039/C9RA06993C. ...
DOI:
10.1039/d1ra90074a

5. Mutual stain conversion between Giemsa and Papanicolaou in cytological images using cycle generative adversarial network

Author:
Teramoto, Atsushi; Yamada, Ayumi; Tsukamoto, Tetsuya; Kiriyama, Yuka; Sakurai, Eiko; Shiogama, Kazuya; Michiba, Ayano; Imaizumi, Kazuyoshi; Saito, Kuniaki; Fujita, Hiroshi
Source:
Heliyon 2021 v.7 no.2 pp. e06331
ISSN:
2405-8440
Subject:
lung neoplasms,   etc   ; artificial intelligence; cytoplasm; erythrocytes;     Show all 4 Subjects
Abstract:
... Papanicolaou and Giemsa stains used in cytology have different characteristics and complementary roles. In this study, we focused on cycle-consistent generative adversarial network (CycleGAN), which is an image translation technique using deep learning, and we conducted mutual stain conversion between Giemsa and Papanicolaou in cytological images using CycleGAN.A total of 191 Giemsa-stained images ...
DOI:
10.1016/j.heliyon.2021.e06331

6. Rapid increase in mortality attributable to PM2.5 exposure in India over 1998–2015

Author:
Jia, Beixi; Gao, Meng; Zhang, Xiaorui; Xiao, Xiang; Zhang, Shiqing; Lam Yung, Ken Kin
Source:
Chemosphere 2021 v.269 pp. 128715
ISSN:
0045-6535
Subject:
lung neoplasms,   etc   ; air pollution control; models; mortality; India;     Show all 5 Subjects
Abstract:
... PM₂.₅-attributable deaths and years of life lost (YLL) due to specific causes during 1998–2015 in India were estimated using the integrated exposure-response (IER) model. The estimated PM₂.₅-mortality in India revealed an annual increasing rate of 2.7% during the study period. Spatially, deaths due to the exposure to ambient PM₂.₅ concentrated mostly in populated North India, and four northern sta ...
DOI:
10.1016/j.chemosphere.2020.128715

7. Long non-coding RNAs in lung cancer: implications for lineage plasticity-mediated TKI resistance

Author:
Liu, Tongyan; Han, Chencheng; Fang, Panqi; Zhu, Hongyu; Wang, Siwei; Ma, Zhifei; Zhang, Quanli; Xia, Wenjia; Wang, Jie; Xu, Lin; Yin, Rong
Source:
Cellular and molecular life sciences 2021 v.78 no.5 pp. 1983-2000
ISSN:
1420-682X
Subject:
lung neoplasms,   etc   ; ; histology; oncogenes; relapse; somatic mutation; therapeutics; tyrosine;     Show all 8 Subjects
Abstract:
... The efficacy of targeted therapy in non-small-cell lung cancer (NSCLC) has been impeded by various mechanisms of resistance. Besides the mutations in targeted oncogenes, reversible lineage plasticity has recently considered to play a role in the development of tyrosine kinase inhibitors (TKI) resistance in NSCLC. Lineage plasticity enables cells to transfer from one committed developmental pathway ...
DOI:
10.1007/s00018-020-03691-9

8. Retraction: Long non-coding RNA MEG3 inhibits cell proliferation, migration, invasion and enhances apoptosis in non-small cell lung cancer cells by regulating the miR-31-5p/TIMP3 axis

Author:
Fisher, Laura
Source:
RSC advances 2021 v.11 no.10 pp. 5701
ISSN:
2046-2069
Subject:
lung neoplasms,   etc   ; apoptosis; cell proliferation; non-coding RNA;     Show all 4 Subjects
Abstract:
... Retraction of ‘Long non-coding RNA MEG3 inhibits cell proliferation, migration, invasion and enhances apoptosis in non-small cell lung cancer cells by regulating the miR-31-5p/TIMP3 axis’ by Kui Li et al., RSC Adv., 2019, 9, 38200–38208, DOI: 10.1039/C9RA07880K. ...
DOI:
10.1039/d1ra90065j

9. Piperlongumine inhibits the growth of non-small cell lung cancer cells via the miR-34b-3p/TGFBR1 pathway

Author:
Lu, Xinhua; Xu, Chenyang; Xu, Zhexuan; Lu, Chunya; Yang, Rui; Zhang, Furui; Zhang, Guojun
Source:
BMC complementary medicine and therapies 2021 v.21 no.1 pp. 15
ISSN:
2662-7671
Subject:
lung neoplasms,   etc   ; Piper longum; alkaloids; alternative medicine; apoptosis; bioluminescence assay; epithelium; genes; humans; metastasis; microRNA; toxicity;     Show all 12 Subjects
Abstract:
... BACKGROUND: Non-small cell lung cancer is a common type of lung cancer. Piperlongumine (PL), which is extracted from the roots of piperaceae plant, long pepper, and peppercorn, is an alkaloid amide that inhibits tumor growth and metastasis. However, whether it affects lung cancer cells remains unclear. METHODS: We assessed the effects of PL on the proliferation and apoptosis of A549 and H1299 NSCL ...
DOI:
10.1186/s12906-020-03123-y

10. Comparison of the AWGS and optimal stratification-defined handgrip strength thresholds for predicting survival in patients with lung cancer

Author:
Yin, Liangyu; Zhang, Ling; Li, Na; Guo, Jing; Liu, Lijuan; Lin, Xin; Fan, Yang; Liu, Jie; Zhang, Mengyuan; Chong, Feifei; Chen, Xiao; Wang, Chang; Wang, Xu; Liang, Tingting; Liu, Xiangliang; Deng, Li; Li, Wei; Yang, Mei; Yu, Jiami; Wang, Xiaojie; Liu, Xing; Yang, Shoumei; Zuo, Zheng; Yuan, Kaitao; Yu, Miao; Song, Chunhua; Cui, Jiuwei; Li, Suyi; Guo, Zengqing; Shi, Hanping; Xu, Hongxia
Source:
Nutrition 2021 v.90 pp. 111258
ISSN:
0899-9007
Subject:
lung neoplasms,   etc   ; cohort studies; death; females; hand strength; mortality; nutrition; sarcopenia; China;     Show all 9 Subjects
Abstract:
... Handgrip strength (HGS) is related to cancer mortality. The aim of this study was to compare the performance of the Asian Working Group for Sarcopenia 2019 (AWGS)- and optimal stratification (OS)-defined HGS thresholds for predicting the survival of patients with lung cancer (LC).We performed an observational cohort study including 3230 patients with LC admitted to five institutions in China from ...
DOI:
10.1016/j.nut.2021.111258

11. Temporal variation of PM2.5-associated health effects in Shijiazhuang, Hebei

Author:
Gao, Aifang; Wang, Junyi; Luo, Jianfei; Li, Aiguo; Chen, Kaiyu; Wang, Pengfei; Wang, Yiyi; Li, Jingyi; Hu, Jianlin; Zhang, Hongliang
Source:
Frontiers of environmental science & engineering 2021 v.15 no.5 pp. 82
ISSN:
2095-2201
Subject:
lung neoplasms,   etc   ; environmental science; heart; human health; models; mortality; particulates; temporal variation; China;     Show all 9 Subjects
Abstract:
... Shijiazhuang is one of the cities in the North China Plain. In recent decades, this city has experienced high levels of fine particulate matter (PM₂.₅), which have potentially significant effects on human health. In this study, the health effects of PM₂.₅ exposure in Shijiazhuang were estimated by applying an integrated exposure-response model. Premature mortality, years of life lost (YLL), and th ...
DOI:
10.1007/s11783-020-1376-0

12. Epigenome-wide DNA methylation signature of benzo[a]pyrene exposure and their mediation roles in benzo[a]pyrene-associated lung cancer development

Author:
Meng, Hua; Li, Guyanan; Wei, Wei; Bai, Yansen; Feng, Yue; Fu, Ming; Guan, Xin; Li, Mengying; Li, Hang; Wang, Chenming; Jie, Jiali; Wu, Xiulong; He, Meian; Zhang, Xiaomin; Wei, Sheng; Li, Yangkai; Guo, Huan
Source:
Journal of hazardous materials 2021 v.416 pp. 125839
ISSN:
0304-3894
Subject:
lung neoplasms,   etc   ; DNA; DNA methylation; carcinogenesis; carcinogens; enzyme-linked immunosorbent assay; lungs; meta-analysis; risk;     Show all 9 Subjects
Abstract:
... Benzo[a]pyrene (B[a]P) is a typical carcinogen associated with increased lung cancer risk, but the underlying mechanisms remain unclear. This study aimed to investigate epigenome-wide DNA methylation associated with B[a]P exposure and their mediation effects on B[a]P-lung cancer association in two lung cancer case-control studies of 462 subjects. Their plasma levels of benzo[a]pyrene diol epoxide- ...
DOI:
10.1016/j.jhazmat.2021.125839

13. Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis

Author:
Song, Zhiyu; Jia, Gang; Ma, Peizhi; Cang, Shundong
Source:
Life sciences 2021 v.276 pp. 119399
ISSN:
0024-3205
Subject:
lung neoplasms,   etc   ; bioinformatics; cell proliferation; cisplatin; exosomes; ferroptosis; genes; luciferase; microRNA; therapeutics;     Show all 10 Subjects
Abstract:
... Exosomal transfer of miRNAs affects recipient cell proliferation and chemoresistance. Here, we aimed to investigate the role of exosomal miRNAs in controlling cisplatin resistance in non-small cell lung carcinoma (NSCLC).Paired tumor and normal tissue-derived exosomes were collected from NSCLC patients with low or high responsiveness to cisplatin treatment. The results showed that the microRNA-444 ...
DOI:
10.1016/j.lfs.2021.119399

14. Aberrant methylation modifications reflect specific drug responses in small cell lung cancer

Author:
Chen, Peixin; Guo, Haoyue; Liu, Yu; Chen, Bin; Zhao, Sha; Wu, Shengyu; Li, Wei; Wang, Lei; Jia, Keyi; Wang, Hao; Jiang, Minlin; Tang, Xuzhen; Qi, Hui; Dai, Chunlei; Ye, Junyan; He, Yayi
Source:
Genomics 2021 v.113 no.3 pp. 1114-1126
ISSN:
0888-7543
Subject:
lung neoplasms,   etc   ; DNA methylation; drug therapy; drugs; genomics; microRNA; precipitin tests; transcription initiation site;     Show all 8 Subjects
Abstract:
... In the study, Methylated DNA immunoprecipitation sequencing, RNA sequencing, and whole-exome sequencing were employed to clinical small cell lung cancer (SCLC) patients. Then, we verified the therapeutic predictive effects of differentially methylated genes (DMGs) in 62 SCLC cell lines. Of 4552 DMGs between chemo-sensitive and chemo-insensitive group, coding genes constituted the largest percentag ...
DOI:
10.1016/j.ygeno.2020.12.045

15. LC3B/p62-mediated mitophagy protects A549 cells from resveratrol-induced apoptosis

Author:
Zheng, Jiahua; Wei, Shaochai; Xiao, Tingting; Li, Guanwu
Source:
Life sciences 2021 v.271 pp. 119139
ISSN:
0024-3205
Subject:
lung neoplasms,   etc   ; Western blotting; antineoplastic activity; apoptosis; fluorescence; fluorescent antibody technique; lysosomes; mitochondria; mitophagy; rapamycin; resveratrol;     Show all 11 Subjects
Abstract:
... Complicated mechanisms in cancer cells have been restricting the medicinal value of resveratrol (Res). The mechanisms by which Res exerts its anti-tumor activity in lung cancer cells have diverged among reports in recent years, whether cells choose to undergo autophagic cell death or apoptosis remains controversial. Yet, whether Res-induced autophagic cell death transforms into apoptosis is still ...
DOI:
10.1016/j.lfs.2021.119139

16. PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis

Author:
Kim, Moon Jong; Cervantes, Christopher; Jung, Youn-Sang; Zhang, Xiaoshan; Zhang, Jie; Lee, Sung Ho; Jun, Sohee; Litovchick, Larisa; Wang, Wenqi; Chen, Junjie; Fang, Bingliang; Park, Jae-Il
Source:
Molecular cell 2021 v.81 no.8 pp. 1698-1714.e6
ISSN:
1097-2765
Subject:
lung neoplasms,   etc   ; adenocarcinoma; carcinogenesis; cell cycle; lungs; mice; prognosis; therapeutics; transcriptional activation; transcriptome;     Show all 10 Subjects
Abstract:
... The DREAM complex orchestrates cell quiescence and the cell cycle. However, how the DREAM complex is deregulated in cancer remains elusive. Here, we report that PAF (PCLAF/KIAA0101) drives cell quiescence exit to promote lung tumorigenesis by remodeling the DREAM complex. PAF is highly expressed in lung adenocarcinoma (LUAD) and is associated with poor prognosis. Importantly, Paf knockout markedly ...
DOI:
10.1016/j.molcel.2021.02.001

17. The aging lung: Physiology, disease, and immunity

Author:
Schneider, Jaime L.; Rowe, Jared H.; Garcia-de-Alba, Carolina; Kim, Carla F.; Sharpe, Arlene H.; Haigis, Marcia C.
Source:
Cell 2021 v.184 no.8 pp. 1990-2019
ISSN:
0092-8674
Subject:
lung neoplasms,   etc   ; COVID-19 infection; adaptive immunity; elderly; humans; lungs; pathogenesis; risk; stress response; xenobiotics;     Show all 10 Subjects
Abstract:
... The population is aging at a rate never seen before in human history. As the number of elderly adults grows, it is imperative we expand our understanding of the underpinnings of aging biology. Human lungs are composed of a unique panoply of cell types that face ongoing chemical, mechanical, biological, immunological, and xenobiotic stress over a lifetime. Yet, we do not fully appreciate the mechan ...
DOI:
10.1016/j.cell.2021.03.005

18. X-ray-responsive polypeptide nanogel for concurrent chemoradiotherapy

Author:
Wang, Juan; Xu, Weiguo; Zhang, Ning; Yang, Changsheng; Xu, Hengwei; Wang, Zhongtang; Li, Baosheng; Ding, Jianxun; Chen, Xuesi
Source:
Journal of controlled release 2021 v.332 pp. 1-9
ISSN:
0168-3659
Subject:
lung neoplasms,   etc   ; X-radiation; crosslinking; doxorubicin; drug therapy; humans; irradiation; lungs; nanogels; polypeptides; radiotherapy; risk;     Show all 12 Subjects
Abstract:
... Concurrent chemoradiotherapy (CCRT) is a standard treatment regimen for medically inoperable stage III non-small-cell lung carcinoma (NSCLC) owing to its superior prognostics compared with the sequential modality. Nevertheless, the current pattern of CCRT still fails to provide satisfactory survival outcome. Furthermore, CCRT is always accompanied by a higher risk of severe side effects, limiting ...
DOI:
10.1016/j.jconrel.2021.02.003

19. A sensitive spectrophotometric ellipsometry based Aptasensor for the vascular endothelial growth factor detection

Author:
Kariper, Ishak Afsin; Üstündağ, Zafer; Caglayan, Mustafa Oguzhan
Source:
Talanta 2021 v.225 pp. 121982
ISSN:
0039-9140
Subject:
lung neoplasms,   etc   ; aptasensors; assays; detection; early diagnosis; oligonucleotides; spectroscopy; vascular endothelial growth factors;     Show all 8 Subjects
Abstract:
... A sensitive and selective, aptamer and spectroscopic ellipsometry based sensor is reported here for the early diagnosis of breast cancer, which is a common type of cancer following lung cancer. It was aimed to develop a single-step and label-free assay for the sensitive and selective detection of VEGF₁₆₅. To this end, two different aptamers and spectroscopic ellipsometry were used. In the presente ...
DOI:
10.1016/j.talanta.2020.121982

20. Identification of protocatechuic acid as a novel blocker of epithelial‐to‐mesenchymal transition in lung tumor cells

Author:
Yang, Min Hee; Baek, Seung Ho; Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali; Ahn, Kwang Seok
Source:
Phytotherapy research 2021 v.35 no.4 pp. 1953-1966
ISSN:
0951-418X
Subject:
lung neoplasms,   etc   ; antioxidants; cadherins; epithelium; fibronectins; metastasis; migratory behavior; occludins; phytotherapy; protocatechuic acid; research; snails; vimentin;     Show all 13 Subjects
Abstract:
... Protocatechuic acid (PA) is widely distributed and commonly occurring natural compound that can exert antioxidant, anti‐inflammatory, as well as anti‐cancer effects. Epithelial‐to‐mesenchymal transition (EMT) is important cellular process that can control tumor invasion and metastasis. Here, we investigated whether PA can modulate the EMT process in basal and transforming growth factorβ‐induced A5 ...
DOI:
10.1002/ptr.6938