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1. Identifying individual predictive factors for treatment efficacy

Author:
Ariel Alonso; Wim Van der Elst; Lizet Sanchez; Patricia Luaces; Geert Molenberghs
Source:
Biometrics 2022 v.78 no.1 pp. 35-45
ISSN:
0006-341X
Subject:
lung neoplasms,   etc   ; immunotherapy; mathematical theory; models; vaccines;     Show all 5 Subjects
Abstract:
... Given the heterogeneous responses to therapy and the high cost of treatments, there is an increasing interest in identifying pretreatment predictors of therapeutic effect. Clearly, the success of such an endeavor will depend on the amount of information that the patient‐specific variables convey about the individual causal treatment effect on the response of interest. In the present work, using ca ...
DOI:
10.1111/biom.13398

2. Arsenic, tobacco use, and lung cancer: An occupational cohort with 27 follow-up years

Author:
Zheng Su; Meng-Na Wei; Xin-Hua Jia; Ya-Guang Fan; Fang-Hui Zhao; Qing-Hua Zhou; Philip R. Taylor; You-Lin Qiao
Source:
Environmental research 2022 v.206 pp. 112611
ISSN:
0013-9351
Subject:
lung neoplasms,   etc   ; arsenic; childhood; research; risk; tin; tobacco use;     Show all 7 Subjects
Abstract:
... We explored the shape of the exposure-response relationship of arsenic-related lung cancer and the interaction between arsenic and tobacco use. A total of 3278 tin miners with at least 10 years of arsenic exposure were enrolled since 1992 and followed up for 27 years. After excluding radon-exposed miners and former smokers, 1620 miners were included into the sub-cohort. Lung cancer risks were esti ...
DOI:
10.1016/j.envres.2021.112611

3. The effects of 1-and 3-positions substitutions on the photophysical properties of perylene and its application in thiol fluorescent probes

Author:
Qin He; Fangdi Dong; Longjiang Xing; Huahong He; Xiaoping Chen; Huaqian Wang; Shaomin Ji; Yanping Huo
Source:
Tetrahedron 2022 v.104 pp. 132565
ISSN:
0040-4020
Subject:
lung neoplasms,   etc   ; fluorescence; nitro compounds; photoluminescence; solvents; thiols; toluene;     Show all 7 Subjects
Abstract:
... A series of perylene derivatives bearing electron-donating group (amino) and electron-withdrawing group (nitro, maleimide) at the 1- and 3-position have been synthesized. Interestingly, 3-monosubstituted perylenes shown different photophysical properties compared with 1-monosubstituted perylenes. 3-nitroperylene (3-NO) attained 80.62% photoluminescence quantum yield (ΦPL) in toluene which is highe ...
DOI:
10.1016/j.tet.2021.132565

4. CD48-expressing non-small-cell lung cancer cells are susceptible to natural killer cell–mediated cytotoxicity

Author:
Eun Jae Park; Hye Won Jun; Ik Ho Na; Hong Kyung Lee; Jieun Yun; Hyung Sook Kim; Youngsoo Kim; Jin Tae Hong; Sang-Bae Han
Source:
Archives of pharmacal research 2022 v.45 no.1 pp. 1-10
ISSN:
0253-6269
Subject:
lung neoplasms,   etc   ; cytotoxicity; intercellular adhesion molecule-1; ligands; research; therapeutics;     Show all 6 Subjects
Abstract:
... The susceptibility of cancer cells to natural killer (NK) cell–mediated cytotoxicity depends on the balance of activating and inhibitory ligands expressed on their surface. Although many types of cancer cells are killed by NK cells, non-small-cell lung cancer (NSCLC) cells are relatively resistant to NK cell–mediated cytotoxicity. In this study, we showed that several NSCLC cell lines have differe ...
DOI:
10.1007/s12272-021-01365-z

5. KDM6A missense variants hamper H3 histone demethylation in lung squamous cell carcinoma

Author:
Tommaso Biagini; Francesco Petrizzelli; Salvatore Daniele Bianco; Niccolò Liorni; Alessandro Napoli; Stefano Castellana; Angelo Luigi Vescovi; Massimo Carella; Viviana Caputo; Tommaso Mazza
Source:
Computational and Structural Biotechnology Journal 2022 v.20 pp. 3151-3160
ISSN:
2001-0370
Subject:
lung neoplasms,   etc   ; biotechnology; demethylation; genes; histones; lungs; squamous cell carcinoma;     Show all 7 Subjects
Abstract:
... KDM6A is the disease causative gene of type 2 Kabuki Syndrome, a rare multisystem disease; it is also a known cancer driver gene, with multiple somatic mutations found in a few cancer types. In this study, we looked at eleven missense variants in lung squamous cell carcinoma, one of the most common lung cancer subtypes, to see how they affect the KDM6A catalytic mechanisms. We found that they infl ...
DOI:
10.1016/j.csbj.2022.06.041

6. Semisynthesis and Non-Small-Cell Lung Cancer Cytotoxicity Evaluation of Germacrane-Type Sesquiterpene Lactones from Elephantopus scaber

Author:
Hui Ren; Yang-Yang Zhang; Ya-Ling Li; Ming Bai; Qiu-Lin Yan; Xiao-Xiao Huang; Wei Cui; Hongwei Zhao; Liwei Gu; Qingbo Liu; Guo-Dong Yao; Shao-Jiang Song
Source:
Journal of natural products 2022 v.85 no.2 pp. 352-364
ISSN:
1520-6025
Subject:
lung neoplasms,   etc   ; Elephantopus scaber; apoptosis; cisplatin; cytotoxicity; mitochondria; sesquiterpenoid lactones;     Show all 7 Subjects
Abstract:
... Two series of germacrane-type sesquiterpene lactones were produced by semisynthetic modulation of scaberol C, which was prepared by a standard chemical transformation from an Elephantopus scaber extract. Their inhibition activities against non-small-cell lung cancer cells were screened, and preliminary structure–activity relationships were also established. Among them, monomeric analog 1u and dime ...
DOI:
10.1021/acs.jnatprod.1c00936

7. Spatial CRISPR genomics identifies regulators of the tumor microenvironment

Author:
Maxime Dhainaut; Samuel A. Rose; Guray Akturk; Aleksandra Wroblewska; Sebastian R. Nielsen; Eun Sook Park; Mark Buckup; Vladimir Roudko; Luisanna Pia; Robert Sweeney; Jessica Le Berichel; C. Matthias Wilk; Anela Bektesevic; Brian H. Lee; Nina Bhardwaj; Adeeb H. Rahman; Alessia Baccarini; Sacha Gnjatic; Dana Pe’er; Miriam Merad; Brian D. Brown
Source:
Cell 2022 v.185 no.7 pp. 1223-1239.e20
ISSN:
0092-8674
Subject:
lung neoplasms,   etc   ; bioavailability; fibroblasts; genes; genomics; histopathology; immunosuppression; mice; transcriptomics;     Show all 9 Subjects
Abstract:
... While CRISPR screens are helping uncover genes regulating many cell-intrinsic processes, existing approaches are suboptimal for identifying extracellular gene functions, particularly in the tissue context. Here, we developed an approach for spatial functional genomics called Perturb-map. We applied Perturb-map to knock out dozens of genes in parallel in a mouse model of lung cancer and simultaneou ...
DOI:
10.1016/j.cell.2022.02.015

8. Splicing Variants, Protein-Protein Interactions, and Drug Targeting in Hutchinson-Gilford Progeria Syndrome and Small Cell Lung Cancer

Author:
Bae-Hoon Kim; Tae-Gyun Woo; So-Mi Kang; Soyoung Park; Bum-Joon Park
Source:
Genes 2022 v.13 no.2 pp. -
ISSN:
2073-4425
Subject:
lung neoplasms,   etc   ; DNA; drugs; genes; homeostasis; messenger RNA; proteomics; therapeutics;     Show all 8 Subjects
Abstract:
... Alternative splicing (AS) is a biological operation that enables a messenger RNA to encode protein variants (isoforms) that give one gene several functions or properties. This process provides one of the major sources of use for understanding the proteomic diversity of multicellular organisms. In combination with post-translational modifications, it contributes to generating a variety of protein–p ...
DOI:
10.3390/genes13020165

9. Calcium carbonate carriers for combined chemo- and radionuclide therapy of metastatic lung cancer

Author:
Alexander S. Timin; Alisa S. Postovalova; Timofey E. Karpov; Dmitrii Antuganov; Anastasia S. Bukreeva; Darya R. Akhmetova; Anna S. Rogova; Albert R. Muslimov; Svetlana A. Rodimova; Daria S. Kuznetsova; Mikhail V. Zyuzin
Source:
Journal of controlled release 2022 v.344 pp. 1-11
ISSN:
0168-3659
Subject:
lung neoplasms,   etc   ; absorbance; calcium carbonate; cisplatin; drug therapy; lungs; metastasis; radiometry;     Show all 8 Subjects
Abstract:
... Considering the clinical limitations of individual approaches against metastatic lung cancer, the use of combined therapy can potentially improve the therapeutic effect of treatment. However, determination of the appropriate strategy of combined treatment can be challenging. In this study, combined chemo- and radionuclide therapy has been realized using radionuclide carriers (¹⁷⁷Lu-labeled core-sh ...
DOI:
10.1016/j.jconrel.2022.02.021

10. Hemoglobin-catalyzed atom transfer radical polymerization for ultrasensitive electrochemical DNA detection

Author:
Nan Ma; Jingliang Liu; Lianzhi Li; Weibo Huang; Wenhao Qiu; Jian Zhang; Jinming Kong; Xueji Zhang
Source:
Biosensors & bioelectronics 2022 v.213 pp. 114485
ISSN:
0956-5663
Subject:
lung neoplasms,   etc   ; DNA; biosensors; detection limit; electrochemistry; hemoglobin; peptides; phosphates; polymerization;     Show all 9 Subjects
Abstract:
... The use of hemoglobin (Hb) to drive atom transfer radical polymerization (ATRP) process (Hb-ATRP) for detection of lung cancer related nucleic acid is firstly reported. Hb does not need to be treated prior to using indicating the potential for synthetic engineering in complex biological microenvironments without the need for in vitro techniques. Here, we report a new signal amplification strategy ...
DOI:
10.1016/j.bios.2022.114485

11. Low‐dose CT lung cancer screening uptake: A rural–urban comparison

Author:
Anja Zgodic; Whitney E. Zahnd; Shailesh Advani; Jan M. Eberth
Source:
Journal of rural health 2022 v.38 no.1 pp. 40-53
ISSN:
0890-765X
Subject:
lung neoplasms,   etc   ; educational status; income; insurance; monitoring; risk factors; rural health;     Show all 7 Subjects
Abstract:
... PURPOSE: The US Preventive Services Task Force recommends lung cancer screening with Low‐Dose Computed Tomography (LDCT) in high‐risk individuals. Our objective was to identify demographic, health, and financial factors associated with screening uptake, with a focus on urban–rural differences. METHODS: We analyzed data from the 2018 and 2019 Behavioral Risk Factor Surveillance System and its optio ...
DOI:
10.1111/jrh.12568

12. Population attributable fraction of lung cancer due to genetic variants, modifiable risk factors, and their interactions: a nationwide prospective cohort study

Author:
Xiaojie Wang; Zhengmin (Min) Qian; Zilong Zhang; Miao Cai; Lan Chen; Yinglin Wu; Haitao Li; Echu Liu; Stephen Edward McMillin; Hualiang Lin
Source:
Chemosphere 2022 v.301 pp. 134773
ISSN:
0045-6535
Subject:
lung neoplasms,   etc   ; air pollution; cohort studies; environmental exposure; lifestyle; risk factors;     Show all 6 Subjects
Abstract:
... Genetic variants and modifiable risk factors (including environmental exposure and lifestyle) greatly contribute to the development of lung cancer. The population attributable fraction (PAF) of these risk factors, especially their interactive effects, has not been well quantified. A total of 398,577 participants were included in this analysis. There were 2504 incident lung cancer cases identified ...
DOI:
10.1016/j.chemosphere.2022.134773

13. Thiazolidinedione-Based Structure Modification of Celastrol Provides Thiazolidinedione-Conjugated Derivatives as Potent Agents against Non-Small-Cell Lung Cancer Cells through a Mitochondria-Mediated Apoptotic Pathway

Author:
Xuefeng Fu; Qing Mao; Bing Zhang; Jialun Lv; Kunqi Ping; Peng Zhang; Fengwei Lin; Jiaxing Zhao; Yao Feng; Jincheng Yang; Huiyu Wang; Lei Zhang; Yanhua Mou; Shaojie Wang
Source:
Journal of natural products 2022 v.85 no.4 pp. 1147-1156
ISSN:
1520-6025
Subject:
lung neoplasms,   etc   ; Western blotting; apoptosis; cell lines; cytotoxicity; iodides; mice; xenotransplantation;     Show all 8 Subjects
Abstract:
... In order to improve the potential of celastrol against non-small-cell lung cancer cells, the privileged structure, thiazolidinedione, was introduced into its C-20 carboxylic group with acetylpiperazine as a linker, and the thiazolidinedione-conjugated compounds 10a–10t were prepared. The target compounds were evaluated for their cytotoxic activities against the A549 cell line, and the results show ...
DOI:
10.1021/acs.jnatprod.2c00104

14. Natural products based crown ethers: synthesis and their anticancer potential

Author:
Tahseen Iqbal; Nuzhat Arshad; Jamshed Hashim; Syed Abid Ali; Binte Zehra; Malik Shoaib Ahmad; Nabila Hassan; Arif Ullah; Syeda Zehra Hamid; Ibanga Okon Isaac
Source:
Journal of Asian natural products research 2022 v.24 no.3 pp. 268-277
ISSN:
1477-2213
Subject:
lung neoplasms,   etc   ; adenocarcinoma; breasts; chrysin; cisplatin; comparative study; cytotoxicity; neoplasm cells; research;     Show all 9 Subjects
Abstract:
... Natural products based novel crown ethers have been prepared by employing biologically active natural structures including tetrahydroisoquinoline, chrysin and biochanin-A as the side arms. The resulting crown scaffolds were evaluated for their anticancer potential against two cancer cell lines i.e. NCI-H460 (non-small lung carcinoma), MCF-7 (breast adenocarcinoma). The comparative study showed tha ...
DOI:
10.1080/10286020.2021.1918118

15. Notch pathway inhibition mediated by arsenic trioxide depletes tumor initiating cells in small cell lung cancer

Author:
Meng-Hang Yang; Bing Li; Ke-Jie Chang
Source:
Molecular biology reports 2022 v.49 no.3 pp. 2245-2253
ISSN:
0301-4851
Subject:
lung neoplasms,   etc   ; arsenic oxide; cell proliferation; humans; molecular biology; stem cells; xenotransplantation;     Show all 7 Subjects
Abstract:
... BACKGROUND: Small cell lung cancer (SCLC) is the most malignant type of lung cancer. We previously reported that arsenic trioxide (As₂O₃) inhibited tumor initiating cells (TICs) of SCLC in vitro. In the present study, we aimed to identify the above effect in vivo and shed light on its underlying mechanism. METHODS AND RESULTS: TICs were enriched by culturing human SCLC cell line as sphere cells in ...
DOI:
10.1007/s11033-021-07046-w

16. Berberisides A-D: three novel prenylated benzoic acid derivatives and a clerodane glycoside from Berberis tsarica aherndt.

Author:
Zhao-Yue Dong; Qing-Hong Zeng; Lin Wei; Xin Guo; Yan Sun; Fan-Cheng Meng; Guo-Wei Wang; Xiao-Zhong Lan; Zhi-Hua Liao; Min Chen
Source:
Natural product research 2022 v.36 no.8 pp. 1996-2001
ISSN:
1478-6427
Subject:
lung neoplasms,   etc   ; Berberis; benzoic acid; breast neoplasms; cytotoxicity; glycosides; hepatoma; neoplasm cells; research;     Show all 9 Subjects
Abstract:
... Three undescribed prenylated benzoic acid derivatives berberisides A-C (1-3) and a new clerodane glycoside berberiside D (4) were isolated from Berberis tsarica Aherndt. Their structures were elucidated on the basis of extensive NMR and HR-ESI-MS analysis. The in vitro cytotoxic activities of all isolates were studied against lung carcinoma A549, hepatocellular carcinoma HepG2 and breast carcinoma ...
DOI:
10.1080/14786419.2020.1839460

17. Does air pollution contribute to urban–rural disparity in male lung cancer diseases in China?

Author:
Huagui Guo; Weifeng Li; Jiansheng Wu; Hung Chak Ho
Source:
Environmental science and pollution research 2022 v.29 no.16 pp. 23905-23918
ISSN:
0944-1344
Subject:
lung neoplasms,   etc   ; air pollutants; air pollution; males; mortality; research; structural equation modeling; China;     Show all 8 Subjects
Abstract:
... It remains unknown whether exposure to ambient air pollution can be a mediator linking socioeconomic indicator to health outcome. The present study aims to examine the mediation effect of PM₂.₅ air pollution on the association between urban–rural division and the incidence (mortality) rate of male lung cancer. We performed a nationwide analysis in 353 counties (districts) of China between 2006 and ...
DOI:
10.1007/s11356-021-17406-5

18. Loss of TIPE3 reduced the proliferation, survival and migration of lung cancer cells through inactivation of Akt/mTOR, NF-κB, and STAT-3 signaling cascades

Author:
Devivasha Bordoloi; Choudhary Harsha; Ganesan Padmavathi; Kishore Banik; Bethsebie Lalduhsaki Sailo; Nand Kishor Roy; Sosmitha Girisa; Krishan Kumar Thakur; Amrita Devi Khwairakpam; Arunachalam Chinnathambi; Tahani Awad Alahmadi; Sulaiman Ali Alharbi; Mehdi Shakibaei; Ajaikumar B. Kunnumakkara
Source:
Life sciences 2022 v.293 pp. 120332
ISSN:
0024-3205
Subject:
lung neoplasms,   etc   ; biomarkers; carcinogenesis; interphase; lipids; lungs; risk factors; survival rate; therapeutics; tobacco;     Show all 10 Subjects
Abstract:
... Lung cancer is the foremost cause of cancer related mortality among men and one of the most fatal cancers among women. Notably, the 5-year survival rate of lung cancer is very low; 5% in developing countries. This low survival rate can be attributed to factors like late stage diagnosis, rapid postoperative recurrences in the patients undergoing treatment and development of chemoresistance against ...
DOI:
10.1016/j.lfs.2022.120332

19. Pump-free microfluidic magnetic levitation approach for density-based cell characterization

Author:
Qiu-Hua Gao; Baiqing Wen; Yani Kang; Wen-Ming Zhang
Source:
Biosensors & bioelectronics 2022 v.204 pp. 114052
ISSN:
0956-5663
Subject:
lung neoplasms,   etc   ; biosensors; drug therapy; magnetism; organ-on-a-chip; quantitative analysis; vision;     Show all 7 Subjects
Abstract:
... Magnetic levitation (MagLev) provides a simple but promising method for density-based analysis and detection down to the individual cell level. However, each existing MagLev configuration for the single-cell density measurement, mainly consisting of a capillary (∼50 mm) placed between two magnets, yields a fairly low sample utilization because of no knowledge about the sample cells in the regions ...
DOI:
10.1016/j.bios.2022.114052

20. Endertiins A-B, two lanostane triterpenoids from the fruit bodies of the mushoom Humphreya endertii

Author:
Dang Ngoc Quang; Le Duc Long; Nguyen Quang Tung; Nguyen Ngoc Thanh; Le Xuan Tham
Source:
Natural product research 2022 v.36 no.3 pp. 748-753
ISSN:
1478-6427
Subject:
lung neoplasms,   etc   ; Ganodermataceae; breast neoplasms; cytotoxicity; ergosterol; fruits; humans; mushrooms; neoplasm cells; research; triterpenoids;     Show all 11 Subjects
Abstract:
... Two new lanostane triterpnenoids named endertiins A and B (1 and 2) together with two known compounds as ganodecalone A (3) and ergosterol (4) have been successfully isolated from the cultivated fruit bodies of the mushroom Humphreya endertii Stey (Ganodermataceae). Their structures were elucidated by a combination of HR-MS and 2 D NMR spectroscopic analyses. In addition, endertiins A and B (1 and ...
DOI:
10.1080/14786419.2020.1800696