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1. NLRP3 inflammasome activation determines the fibrogenic potential of PM2.5 air pollution particles in the lung

Author:
Cao, Wei; Wang, Xiang; Li, Jiulong; Yan, Ming; Chang, Chong Hyun; Kim, Joshua; Jiang, Jinhong; Liao, Yu-Pei; Tseng, Shannon; Kusumoputro, Sydney; Lau, Candice; Huang, Marissa; Han, Pengli; Lu, Pengju; Xia, Tian
Source:
Journal of environmental sciences (China) 2022 v.111 pp. 429-441
ISSN:
1001-0742
Subject:
lungs,   etc   ; ; air pollution; cathepsin B; collagen; cytotoxicity; epithelium; fibrosis; humans; inflammasomes; inflammation; macrophages; particulates; pulmonary fibrosis; China;     Show all 15 Subjects
Abstract:
... Airborne fine particulate matter (PM₂.₅) is known to cause respiratory inflammation such as chronic obstructive pulmonary disease and lung fibrosis. NLRP3 inflammasome activation has been implicated in these diseases; however, due to the complexity in PM₂.₅ compositions, it is difficult to differentiate the roles of the components in triggering this pathway. We collected eight real-life PM₂.₅ samp ...
DOI:
10.1016/j.jes.2021.04.021

2. Harnessing affinity-based protein profiling to reveal a novel target of nintedanib

Author:
Chen, Xiong; Li, Menglin; Li, Manru; Wang, Dongmei; Zhang, Jinlan
Source:
Chemical communications 2021 v.57 no.25 pp. 3139-3142
ISSN:
1364-548X
Subject:
lung neoplasms; lungs,   etc   ; ; pulmonary fibrosis; therapeutics; tyrosine;     Show all 6 Subjects
Abstract:
... Nintedanib (BIBF1120), a triple angiokinase inhibitor, was first approved for idiopathic pulmonary fibrosis (IPF) therapy and is also efficacious for lung carcinoma, and interstitial lung diseases, far beyond its inhibition of VEGFR/PDGFR/FGFR. We identified tripeptidyl-peptidase 1 (TPP1) as one of the direct targets of nintedanib employing the affinity-based protein profiling (AfBPP) technique. T ...
DOI:
10.1039/d1cc00354b

3. Replication of Marek’s disease vaccines in turkey embryos and their effect on TLR-3 and IFN-γ transcripts

Author:
Gimeno, I. M.; Shaw, W. N.; Turner, A.; Bremen, J.; Cortes, A. L.; Faiz, N. M.; Gonder, E.; Robbins, K.
Source:
Avian pathology 2021 v.50 no.3 pp. 227-233
ISSN:
1465-3338
Subject:
lungs,   etc   ; pathogenesis; spleen; vaccination;     Show all 4 Subjects
Abstract:
... Understanding the pathogenesis of herpesvirus of turkeys (HVT) in its natural host is necessary before recombinant HVT (rHVT) can be used efficiently in turkey flocks. The objectives of this study were to evaluate when commercial turkey flocks get infected with wild type HVT, to study replication of HVT (conventional and recombinant rHVT-Newcastle disease, rHVT-ND) and other Marek’s disease (MD) v ...
DOI:
10.1080/03079457.2021.1882937

4. Efficient Estimation of Optimal Regimes Under a No Direct Effect Assumption

Author:
Liu, Lin; Shahn, Zach; Robins, James M.; Rotnitzky, Andrea
Source:
Journal of the American Statistical Association 2021 v.116 no.533 pp. 224-239
ISSN:
1537-274X
Subject:
lung neoplasms,   etc   ; models; patients;     Show all 3 Subjects
Abstract:
... We derive new estimators of an optimal joint testing and treatment regime under the no direct effect (NDE) assumption that a given laboratory, diagnostic, or screening test has no effect on a patient’s clinical outcomes except through the effect of the test results on the choice of treatment. We model the optimal joint strategy with an optimal structural nested mean model (opt-SNMM). The proposed ...
DOI:
10.1080/01621459.2020.1856117

5. Lung cancer: progression of heat shock protein 70 in association with flap endonuclease 1 protein

Author:
Kathera, Chandra Sekhar; Longwei, Jiang; Janardhan, Avilala; Qin, Lihong; Zhang, Qi; Lan, Wu; Shaochang, Jia; Guo, Zhigang
Source:
3 Biotech 2021 v.11 no.3 pp. 141
ISSN:
2190-572X
Subject:
lung neoplasms; lungs,   etc   ; cancer therapy; fluorouracil; heat-shock protein 70;     Show all 5 Subjects
Abstract:
... Lung cancer is one of the leading causes of cancer deaths worldwide and existing approaches are not enough to manage, and hence, it is important to concentrate on new drug strategies. This study was aimed to identify the interacting partner of Flap endonuclease 1 (FEN1) and its role in cancer treatment. We identified a new FEN1 interacting partner confirmed it as Heat Shock Protein 70 (HSP 70), an ...
DOI:
10.1007/s13205-020-02598-3

6. Retraction: CircRNA PVT1 modulates cell metastasis via the miR-181a-5p/NEK7 axis and cisplatin chemoresistance through miR-181a-5p-mediated autophagy in non-small cell lung cancer

Author:
Fisher, Laura
Source:
RSC advances 2021 v.11 no.11 pp. 6256
ISSN:
2046-2069
Subject:
lung neoplasms,   etc   ; autophagy; cisplatin; metastasis;     Show all 4 Subjects
Abstract:
... Retraction of ‘CircRNA PVT1 modulates cell metastasis via the miR-181a-5p/NEK7 axis and cisplatin chemoresistance through miR-181a-5p-mediated autophagy in non-small cell lung cancer’ by Limin Yan et al., RSC Adv., 2019, 9, 42324–42334, DOI: 10.1039/C9RA08872E. ...
DOI:
10.1039/d1ra90075g

7. Understanding Human Lung Development through In Vitro Model Systems

Author:
Conway, Renee F.; Frum, Tristan; Conchola, Ansley S.; Spence, Jason R.
Source:
BioEssays 2020 v.42 no.6 pp. e2000006
ISSN:
0265-9247
Subject:
lungs,   etc   ; ; humans;     Show all 3 Subjects
Abstract:
... An abundance of information about lung development in animal models exists; however, comparatively little is known about lung development in humans. Recent advances using primary human lung tissue combined with the use of human in vitro model systems, such as human pluripotent stem cell‐derived tissue, have led to a growing understanding of the mechanisms governing human lung development. They hav ...
DOI:
10.1002/bies.202000006

8. A model of lung surfactant dynamics based on intrinsic interfacial compressibility

Author:
Bouchoris, K.; Bontozoglou, V.
Source:
Colloids and surfaces 2021 v.624 pp. 126839
ISSN:
0927-7757
Subject:
lungs,   etc   ; adsorption; compressibility; desorption; equations; models; surfactants;     Show all 7 Subjects
Abstract:
... A minimum model for the description of lung surfactant dynamics during consecutive compression/relaxation cycles is proposed. The model is based on Frumkin/Langmuir equilibrium and on an equation of state that includes rigorously the intrinsic compressibility of the densely packed monolayer. Adsorption/desorption dynamics is taken to be kinetically-limited, and film collapse during extreme compres ...
DOI:
10.1016/j.colsurfa.2021.126839

9. Generalized accelerated hazards mixture cure models with interval-censored data

Author:
Liu, Xiaoyu; Xiang, Liming
Source:
Computational statistics & data analysis 2021 v.161 pp. 107248
ISSN:
0167-9473
Subject:
lungs,   etc   ; data analysis; models; statistical analysis;     Show all 4 Subjects
Abstract:
... Existing semiparametric mixture cure models with interval-censored data often assume a survival model, such as the Cox proportional hazards model, proportional odds model, accelerated failure time model, or their transformations for the susceptible subjects. There are cases in practice that such conventional assumptions may be inappropriate for modeling survival outcomes of susceptible subjects. W ...
DOI:
10.1016/j.csda.2021.107248

10. GPRC5B promotes collagen production in myofibroblasts

Author:
Takizawa, Noburo; Hironaka, Takanori; Mae, Kyosuke; Ueno, Tomoyuki; Horii, Yuma; Nagasaka, Akiomi; Nakaya, Michio
Source:
Biochemical and biophysical research communications 2021 v.561 pp. 180-186
ISSN:
0006-291X
Subject:
lungs,   etc   ; collagen; extracellular matrix; fibrosis; research;     Show all 5 Subjects
Abstract:
... Fibrosis is a condition characterized by the overproduction of extracellular matrix (ECM) components (e.g., collagen) in the myofibroblasts, causing tissue hardening and eventual organ dysfunction. Currently, the molecular mechanisms that regulate ECM production in the myofibroblasts are still obscure. In this study, we investigated the function of GPRC5B in the cardiac and lung myofibroblasts usi ...
DOI:
10.1016/j.bbrc.2021.05.035

11. Insights on chronic hypersensitivity pneumonitis' treatment: Factors associated with a favourable response to azathioprine

Author:
Raimundo, Sara; Pimenta, Ana Cláudia; Cruz-Martins, Natália; Rodrigues, Márcio Cunha; Melo, Natália; Mota, Patrícia Caetano; Sokhatska, Oksana; Bastos, Hélder Novais; Beltrão, Marília; Guimarães, Susana; Moura, Conceição Souto; Cunha, Rui; Pereira, José Miguel; Morais, António
Source:
Life sciences 2021 v.272 pp. 119274
ISSN:
0024-3205
Subject:
lungs,   etc   ; histology; hypersensitivity; immunosuppression; pneumonia; therapeutics;     Show all 6 Subjects
Abstract:
... The use of immunosuppressive and antifibrotic agents for the treatment of chronic hypersensitivity pneumonitis (CHP) appears promising, but there is still no evidence supporting the clinical decision regarding the implementation of each specific pharmacological strategy.Patients diagnosed with CHP and treated with azathioprine (AZA) were retrospectively selected from a single centre for Interstiti ...
DOI:
10.1016/j.lfs.2021.119274

12. Consolidated lung on contrast-enhanced chest CT: the use of spectral-detector computed tomography parameters in differentiating atelectasis and pneumonia

Author:
Konietzke, Philip; Steentoft, Hauke H.; Wagner, Willi L.; Albers, Jonas; Dullin, Christian; Skornitzke, Stephan; Stiller, Wolfram; Weber, Tim F.; Kauczor, Hans-Ulrich; Wielpütz, Mark O.
Source:
Heliyon 2021 v.7 no.5 pp. e07066
ISSN:
2405-8440
Subject:
lungs,   etc   ; chest; computed tomography; iodine; pneumonia;     Show all 5 Subjects
Abstract:
... To investigate the value of spectral-detector computed tomography (SDCT) parameters for the quantitative differentiation between atelectasis and pneumonia on contrast-enhanced chest CT.Sixty-three patients, 22 clinically diagnosed with pneumonia and 41 with atelectasis, underwent contrast-enhanced SDCT scans during the venous phase. CT numbers (Hounsfield Units [HU]) were measured on conventional ...
DOI:
10.1016/j.heliyon.2021.e07066

13. Principal manifold estimation via model complexity selection

Author:
Meng, Kun; Eloyan, Ani
Source:
Journal of the Royal Statistical Society 2021 v.83 no.2 pp. 369-394
ISSN:
1369-7412
Subject:
lung neoplasms,   etc   ; algorithms; principal component analysis;     Show all 3 Subjects
Abstract:
... We propose a framework of principal manifolds to model high‐dimensional data. This framework is based on Sobolev spaces and designed to model data of any intrinsic dimension. It includes principal component analysis and principal curve algorithm as special cases. We propose a novel method for model complexity selection to avoid overfitting, eliminate the effects of outliers and improve the computa ...
DOI:
10.1111/rssb.12416

14. Broilers' head behavior as an early warning index of production and lung health under ammonia exposure

Author:
Liu, Qing Xiu; Zhang, Min Hong; Zhou, Ying; Feng, Jing Hai
Source:
Poultry science 2021 v.100 no.3 pp. 100814
ISSN:
0032-5791
Subject:
lungs,   etc   ; ammonia; growth performance; head; males;     Show all 5 Subjects
Abstract:
... This study investigated the effects of ammonia exposure (0, 15, 25, and 35 ppm) on head behavior, production performance and lung tissue morphology of broilers, and the relationship between head behavior, production performance, and lung tissue injury. In this experiment, a total of 264 AA commercial male broilers (21 d old) were assigned to 4 treatment groups with 6 replicates of 11 chickens for ...
DOI:
10.1016/j.psj.2020.10.067

15. Triterpenoids from Walsura trichostemon

Author:
Nugroho, Alfarius Eko; Hirasawa, Yusuke; Kaneda, Toshio; Shirota, Osamu; Matsuno, Michiyo; Mizukami, Hajime; Morita, Hiroshi
Source:
Natural medicines 2021 v.75 no.2 pp. 415-422
ISSN:
1340-3443
Subject:
lungs,   etc   ; bioactive properties; humans; neoplasm cells; triterpenoids;     Show all 5 Subjects
Abstract:
... Bioactivity guided separation of Walsura trichostemon stem methanolic extract led to the isolation of four new dammarane (1–4) and two new apotirucallane triterpenoids (5–6), together with one limonoid (7), 11,25-dideacetyltrichostemonate, 12β, 20S, 24R-trihydroxydammar-25-en-3-one and 12β, 20S, 25-trihydroxydammar-23-en-3-one. Compounds 1–7 showed in vitro inhibitory activity on the proliferation ...
DOI:
10.1007/s11418-021-01483-4

16. Retraction: Long noncoding RNA ANRIL knockdown increases sensitivity of non-small cell lung cancer to cisplatin by regulating the miR-656-3p/SOX4 axis

Author:
Fisher, Laura
Source:
RSC advances 2021 v.11 no.11 pp. 6255
ISSN:
2046-2069
Subject:
lung neoplasms,   etc   ; cisplatin; non-coding RNA;     Show all 3 Subjects
Abstract:
... Retraction of ‘Long noncoding RNA ANRIL knockdown increases sensitivity of non-small cell lung cancer to cisplatin by regulating the miR-656-3p/SOX4 axis’ by Xianfang Wang et al., RSC Adv., 2019, 9, 38735–38744, DOI: 10.1039/C9RA06993C. ...
DOI:
10.1039/d1ra90074a

17. Mutual stain conversion between Giemsa and Papanicolaou in cytological images using cycle generative adversarial network

Author:
Teramoto, Atsushi; Yamada, Ayumi; Tsukamoto, Tetsuya; Kiriyama, Yuka; Sakurai, Eiko; Shiogama, Kazuya; Michiba, Ayano; Imaizumi, Kazuyoshi; Saito, Kuniaki; Fujita, Hiroshi
Source:
Heliyon 2021 v.7 no.2 pp. e06331
ISSN:
2405-8440
Subject:
lung neoplasms,   etc   ; artificial intelligence; cytoplasm; erythrocytes;     Show all 4 Subjects
Abstract:
... Papanicolaou and Giemsa stains used in cytology have different characteristics and complementary roles. In this study, we focused on cycle-consistent generative adversarial network (CycleGAN), which is an image translation technique using deep learning, and we conducted mutual stain conversion between Giemsa and Papanicolaou in cytological images using CycleGAN.A total of 191 Giemsa-stained images ...
DOI:
10.1016/j.heliyon.2021.e06331

18. Methods for frequency and correlation analyses of neurograms

Author:
Horcholle-Bossavit, Ginette; Quenet, Brigitte
Source:
MethodsX 2021 v.8 pp. 101258
ISSN:
2215-0161
Subject:
lungs,   etc   ; autocorrelation; brain stem; frogs; wavelet;     Show all 5 Subjects
Abstract:
... Many physiological functions are based on motor rhythmic activities, among them breathing is a vital issue. The method presented here, or ‘temporal grid extraction’, aims at characterizing the temporal organization of such an activity. Beyond the measurement of the fundamental frequency, defining the successive cycles, some signal processing tools are helpful in order to look for the presence of h ...
DOI:
10.1016/j.mex.2021.101258

19. Aberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer

Author:
Oka, Miho; Xu, Liu; Suzuki, Toshihiro; Yoshikawa, Toshiaki; Sakamoto, Hiromi; Uemura, Hayato; Yoshizawa, Akiyasu C.; Suzuki, Yutaka; Nakatsura, Tetsuya; Ishihama, Yasushi; Suzuki, Ayako; Seki, Masahide
Source:
Genome biology 2021 v.22 no.1 pp. 9
ISSN:
1474-760X
Subject:
lung neoplasms; lungs,   etc   ; T-lymphocytes; absorbents; adenocarcinoma; data collection; genome; peptides; protein synthesis; proteome; transcriptome;     Show all 11 Subjects
Abstract:
... BACKGROUND: Long-read sequencing of full-length cDNAs enables the detection of structures of aberrant splicing isoforms in cancer cells. These isoforms are occasionally translated, presented by HLA molecules, and recognized as neoantigens. This study used a long-read sequencer (MinION) to construct a comprehensive catalog of aberrant splicing isoforms in non-small-cell lung cancers, by which novel ...
DOI:
10.1186/s13059-020-02240-8

20. State of the art on lung organoids in mammals

Author:
Archer, Fabienne; Bobet-Erny, Alexandra; Gomes, Maryline
Source:
Veterinary research 2021 v.52 no.1 pp. 77
ISSN:
1297-9716
Subject:
lung function; lungs,   etc   ; One Health initiative; adults; animal health; genetic disorders; mammals; organoids; veterinary medicine;     Show all 9 Subjects
Abstract:
... The number and severity of diseases affecting lung development and adult respiratory function have stimulated great interest in developing new in vitro models to study lung in different species. Recent breakthroughs in 3-dimensional (3D) organoid cultures have led to new physiological in vitro models that better mimic the lung than conventional 2D cultures. Lung organoids simulate multiple aspects ...
DOI:
10.1186/s13567-021-00946-6