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1. The role of αβ T-cells in spontaneous regression of melanoma tumors in swine

Author:
Cizkova, Jana; Sinkorova, Zuzana; Strnadova, Kristyna; Cervinkova, Monika; Horak, Vratislav; Sinkora, Jiri; Stepanova, Katerina; Sinkora, Marek
Source:
Developmental and comparative immunology 2019 v.92 pp. 60-68
ISSN:
0145-305X
Subject:
T-lymphocytes,   etc   ; loci; melanoma; models; phenotype; swine;     Show all 6 Subjects
Abstract:
... Using a porcine model, we describe Melanoma-Associated CD4+CD8hi T-lymphocytes (MATL) in peripheral blood that increase during melanoma regression. These MATL possess the CD4+CD8hi phenotype and they have their direct counterparts in Tumor Infiltrating Lymphocytes (TIL) isolated from melanoma loci. Both MATL and CD4+CD8hi TIL have a similar expression of selected markers indicating that they repre ...
DOI:
10.1016/j.dci.2018.10.001

2. Bcells and their regulatory functions during Tuberculosis: Latency and active disease

Author:
Loxton, Andre G.
Source:
Molecular immunology 2019 v.111 pp. 145-151
ISSN:
0161-5890
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; Mycobacterium tuberculosis; antibodies; antigens; apoptosis; cytokines; granuloma; immune response; ligands; lungs; tuberculosis;     Show all 12 Subjects
Abstract:
... Tuberculosis (TB) is a global epidemic with devastating consequences. Emerging evidence suggests that B-cells have the ability to modulate the immune response and understanding these roles during Mycobacterium tuberculosis (M.tb) infection can help to find new strategies to treat TB. The immune system of individuals with pulmonary TB form granulomas in the lung which controls the infection by inhi ...
DOI:
10.1016/j.molimm.2019.04.012

3. Optimization of a multivalent peptide vaccine for nicotine addiction

Author:
Zeigler, David F.; Roque, Richard; Clegg, Christopher H.
Source:
Vaccine 2019 v.37 no.12 pp. 1584-1590
ISSN:
0264-410X
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; amino acid sequences; antibodies; haptens; mice; nicotine; protein synthesis; rats; toxicity; vaccines;     Show all 11 Subjects
Abstract:
... We have been optimizing the design of a conjugate vaccine for nicotine addiction that employs a peptide-based hapten carrier. This peptide, which is produced by solid-phase protein synthesis, contains B cell and T cell epitope domains and eliminates the non-relevant, but highly immunogenic sequences in microbial carriers. In this report, the amino acid sequences in the T cell domain were optimized ...
DOI:
10.1016/j.vaccine.2019.02.003

4. An immunohistochemical study of T and B lymphocyte density in prostatic hyperplasia and prostate carcinoma in dogs

Author:
Palmieri, Chiara; Hood, Grace; Fonseca-Alves, Carlos Eduardo; Laufer-Amorim, Renée; Allavena, Rachel
Source:
Research in veterinary science 2019 v.122 pp. 189-192
ISSN:
0034-5288
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; dogs; hyperplasia; immunohistochemistry; immunotherapy; prostate gland; prostatic neoplasms;     Show all 8 Subjects
Abstract:
... The aim of this study was to characterise T and B lymphocyte density in 6 normal prostates, 15 benign prostatic hyperplasia (BPH) and 24 prostate carcinomas (PCs) in dogs by immunohistochemistry. Results revealed a statistically significant increase of T and B cells in PC compared to normal specimens and BPH. Regarding PC histological variants, lower number of CD3+ and CD79+ lymphocytes were obser ...
DOI:
10.1016/j.rvsc.2018.11.022

5. Air pollution exposure and immunological and systemic inflammatory alterations among schoolchildren in China

Author:
Li, Xinwei; Zhang, Xiao; Zhang, Zhiqiang; Han, Lianyu; Gong, Deping; Li, Jie; Wang, Ting; Wang, Yanhua; Gao, Sheng; Duan, Huawei; Kong, Fanling
Source:
The Science of the total environment 2019 v.657 pp. 1304-1310
ISSN:
0048-9697
Subject:
B-lymphocytes; T-lymphocytes; lymphocyte count,   etc   ; C-reactive protein; adults; air; air pollution; biomarkers; chronic exposure; immunoglobulin G; immunotoxicity; males; monocytes; respiratory tract diseases; risk; school children; China;     Show all 17 Subjects
Abstract:
... Exposure to air pollution is associated with an increased risk of respiratory infection, to which children are more susceptible than adults. However, epidemiological evidence regarding the association of chronic exposure to air pollution with the immune and systemic inflammatory function of children is scarce, especially in the context of higher exposure levels. In this study, we included 163 chro ...
DOI:
10.1016/j.scitotenv.2018.12.153

6. For T Cells, the Child Is Father of the Man

Author:
Hogquist, Kristin A.; Hamilton, Sara E.
Source:
Cell 2018 v.174 no.1 pp. 16-18
ISSN:
0092-8674
Subject:
T-lymphocytes,   etc   ; children; pathogens;     Show all 3 Subjects
Abstract:
... When T cells respond to infectious agents, they differentiate into effector and memory cells. In this issue of Cell, Smith et al. use a genetic “time-stamping” method to show that the developmental time the T cell arises—near birth or as an adult—dictates what type of T effector or memory cell results. ...
DOI:
10.1016/j.cell.2018.06.015

7. Engineering the AAV capsid to evade immune responses

Author:
Barnes, Christopher; Scheideler, Olivia; Schaffer, David
Source:
Current opinion in biotechnology 2019 v.60 pp. 99-103
ISSN:
0958-1669
Subject:
lymphocytes,   etc   ; Dependoparvovirus; antibodies; capsid; engineering; gene therapy; immune response; viruses;     Show all 8 Subjects
Abstract:
... Gene therapy is progressively emerging as a promising and powerful therapeutic modality, and adeno-associated virus (AAV) is a major delivery vehicle for such therapies. Among the most significant challenges that limit AAV’s utility, however, is the immune response it elicits. Antibodies elicited by prior exposure to natural virus or vector can bind to an AAV vector, preventing it from entering th ...
DOI:
10.1016/j.copbio.2019.01.002

8. Macrophages: Key orchestrators of a tumor microenvironment defined by therapeutic resistance

Author:
Long, Kristen B.; Collier, Arthur I.; Beatty, Gregory L.
Source:
Molecular immunology 2019 v.110 pp. 3-12
ISSN:
0161-5890
Subject:
T-lymphocytes,   etc   ; antineoplastic activity; macrophages; metastasis; neoplasms; phenotype; therapeutics;     Show all 7 Subjects
Abstract:
... Macrophages have emerged as promising therapeutic targets in cancer. Within tumor tissue, macrophages foster tumor development, invasion, and metastasis. As the phenotype of macrophages is inherently pliable and dependent on cues received from the surrounding microenvironment, macrophages co-evolve with malignant and other non-malignant cells during cancer progression. In doing so, they establish ...
DOI:
10.1016/j.molimm.2017.12.003

9. Neutrophils: Homing in on the myeloid mechanisms of metastasis

Author:
Leach, Joshua; Morton, Jennifer P.; Sansom, Owen J.
Source:
Molecular immunology 2019 v.110 pp. 69-76
ISSN:
0161-5890
Subject:
lymphocytes,   etc   ; macrophages; metastasis; neoplasm cells; neoplasms; neutrophils; stromal cells;     Show all 7 Subjects
Abstract:
... The metastasis cascade is complex and comprises several stages including local invasion into surrounding tissue, intravasation and survival of tumour cells in the circulation, and extravasation and colonisation of a distant site. It is increasingly clear that these processes are driven not only by signals within the tumour cells, but are also profoundly influenced by stromal cells and signals in t ...
DOI:
10.1016/j.molimm.2017.12.013

10. In silico prediction of B-cell epitopes for twenty-five mite allergens: The therapeutic potentials for immunotherapy

Author:
Ebrahimi, Narjes; Nezafat, Navid; Esmaeilzadeh, Hossein; Ghasemi, Younes; Nabavizadeh, Seyed Hesamodin; Alyasin, Soheila
Source:
Molecular and cellular probes 2019
ISSN:
0890-8508
Subject:
B-lymphocytes,   etc   ; allergens; epitopes; immunotherapy; mites; models; prediction; vaccines;     Show all 8 Subjects
Abstract:
... Mite allergens are one of the major allergens; however, their structures and epitopes have not been thoroughly studied. In the present study, we predicted the tertiary structures of several mite allergens and also identified the B-cell epitopes, which can be suggested as potential epitopes for allergen immunotherapy. Twenty-five mite allergens, from six mite allergen groups, were investigated; hom ...
DOI:
10.1016/j.mcp.2019.05.004

11. Gene-Specific H1 Eviction through a Transcriptional Activator→p300→NAP1→H1 Pathway

Author:
Shimada, Miho; Chen, Wei-Yi; Nakadai, Tomoyoshi; Onikubo, Takashi; Guermah, Mohamed; Rhodes, Daniela; Roeder, Robert G.
Source:
Molecular cell 2019 v.74 no.2 pp. 268-283.e5
ISSN:
1097-2765
Subject:
B-lymphocytes,   etc   ; acetylation; chromatin; gene activation; genes; histones; transcription (genetics);     Show all 7 Subjects
Abstract:
... Linker histone H1 has been correlated with transcriptional inhibition, but the mechanistic basis of the inhibition and its reversal during gene activation has remained enigmatic. We report that H1-compacted chromatin, reconstituted in vitro, blocks transcription by abrogating core histone modifications by p300 but not activator and p300 binding. Transcription from H1-bound chromatin is elicited by ...
DOI:
10.1016/j.molcel.2019.02.016

12. Cell therapy products: focus on issues with manufacturing and quality control of chimeric antigen receptor T‐cell therapies

Author:
Eyles, Jim E; Vessillier, Sandrine; Jones, Anika; Stacey, Glyn; Schneider, Christian K; Price, Jack
Source:
Journal of chemical technology and biotechnology 2019 v.94 no.4 pp. 1008-1016
ISSN:
0268-2575
Subject:
T-lymphocytes,   etc   ; cost effectiveness; manufacturing; quality control; therapeutics;     Show all 5 Subjects
Abstract:
... Recent accelerated approvals of Chimeric Antigen Receptor T‐cell (CAR‐T) therapies targeting refractory haematological malignancies underscore the potential for this novel technology platform to provide new therapeutic options for oncology areas with high unmet medical needs. However, these powerful ‘living drugs’ are markedly different to conventional small molecule and biologic therapies on seve ...
DOI:
10.1002/jctb.5829

13. Determination of human γδ T cell–mediated cytotoxicity using a non-radioactive assay system

Author:
Tagod, Mohammed S.O.; Mizuta, Satoshi; Sakai, Yuki; Iwasaki, Masashi; Shiraishi, Kengo; Senju, Hiroaki; Mukae, Hiroshi; Morita, Craig T.; Tanaka, Yoshimasa
Source:
Journal of immunological methods 2019 v.466 pp. 32-40
ISSN:
0022-1759
Subject:
T-lymphocytes,   etc   ; cytotoxicity; europium; fluorescence; humans; neoplasm cells; neoplasms; terbium;     Show all 8 Subjects
Abstract:
... The adoptive transfer of immune effector cells, such as CD8+ killer αβ T cells, γδ T cells, NK (natural killer) cells, and genetically–modified T cells, has been receiving increasing attention. It is essential to determine cellular cytotoxicity so as to monitor the function and quality of ex vivo–expanded immune effector cells before infusion. The most common method is the [51Cr]–sodium chromate r ...
DOI:
10.1016/j.jim.2019.01.003

14. Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

Author:
Mayassi, Toufic; Ladell, Kristin; Gudjonson, Herman; McLaren, James E.; Shaw, Dustin G.; Tran, Mai T.; Rokicka, Jagoda J.; Lawrence, Ian; Grenier, Jean-Christophe; van Unen, Vincent; Ciszewski, Cezary; Dimaano, Matthew; Sayegh, Hoda E.; Kumar, Vinod; Wijmenga, Cisca; Green, Peter H.R.; Gokhale, Ranjana; Jericho, Hilary; Semrad, Carol E.; Guandalini, Stefano; Dinner, Aaron R.; Kupfer, Sonia S.; Reid, Hugh H.; Barreiro, Luis B.; Rossjohn, Jamie; Price, David A.; Jabri, Bana
Source:
Cell 2019 v.176 no.5 pp. 967-981.e19
ISSN:
0092-8674
Subject:
T-lymphocytes,   etc   ; antigens; celiac disease; gluten; immunity; inflammation; monitoring; receptors;     Show all 8 Subjects
Abstract:
... Tissue-resident lymphocytes play a key role in immune surveillance, but it remains unclear how these inherently stable cell populations respond to chronic inflammation. In the setting of celiac disease (CeD), where exposure to dietary antigen can be controlled, gluten-induced inflammation triggered a profound depletion of naturally occurring Vγ4+/Vδ1+ intraepithelial lymphocytes (IELs) with innate ...
DOI:
10.1016/j.cell.2018.12.039

15. Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

Author:
Li, Hanjie; van der Leun, Anne M.; Yofe, Ido; Lubling, Yaniv; Gelbard-Solodkin, Dikla; van Akkooi, Alexander C.J.; van den Braber, Marlous; Rozeman, Elisa A.; Haanen, John B.A.G.; Blank, Christian U.; Horlings, Hugo M.; David, Eyal; Baran, Yael; Bercovich, Akhiad; Lifshitz, Aviezer; Schumacher, Ton N.; Tanay, Amos; Amit, Ido
Source:
Cell 2019 v.176 no.4 pp. 775-789.e18
ISSN:
0092-8674
Subject:
CD8-positive T-lymphocytes,   etc   ; cytotoxicity; genes; humans; immunotherapy; melanoma; patients;     Show all 7 Subjects
Abstract:
... Tumor immune cell compositions play a major role in response to immunotherapy, but the heterogeneity and dynamics of immune infiltrates in human cancer lesions remain poorly characterized. Here, we identify conserved intratumoral CD4 and CD8 T cell behaviors in scRNA-seq data from 25 melanoma patients. We discover a large population of CD8 T cells showing continuous progression from an early effec ...
DOI:
10.1016/j.cell.2018.11.043

16. Doramectin induced cytotoxic and genotoxic effects on bovine peripheral lymphocytes and cumulus cells in vitro

Author:
Anchordoquy, Juan Mateo; Anchordoquy, Juan Patricio; Nikoloff, Noelia; Gambaro, Rocío; Padula, Gisel; Seoane, Analía; Furnus, Cecilia
Source:
Journal of environmental science and health 2019 v.54 no.2 pp. 147-154
ISSN:
1532-4109
Subject:
lymphocytes,   etc   ; DNA damage; cattle; comet assay; cytotoxicity; doramectin; genotoxicity; mutagens;     Show all 8 Subjects
Abstract:
... The effect of doramectin (DOR) was tested on two experimental somatic bovine cells in vitro: peripheral lymphocytes (PL) and cumulus cells (CC). The cytotoxicity and genotoxicity of DOR were assessed using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, single cell gel electrophoresis assay (SCGE) and cytokinesis-block micronucleus cytome (CBMN Cyt) assay. Both cells ...
DOI:
10.1080/03601234.2018.1559569

17. Innate Lymphocytes and Malaria – Players or Spectators?

Author:
Ng, Susanna S.; Engwerda, Christian R.
Source:
Trends in parasitology 2019 v.35 no.2 pp. 154-162
ISSN:
1471-4922
Subject:
T-lymphocytes,   etc   ; antiparasitic agents; immune response; malaria; morbidity; mortality; vaccination;     Show all 7 Subjects
Abstract:
... Malaria remains an important global disease. Despite significant advances over the past decade in reducing disease morbidity and mortality, new measures are needed if malaria is to be eliminated. Significant advances in our understanding about host immune responses during malaria have been made, opening up opportunities to generate long-lasting antiparasitic immunity through vaccination or immune ...
DOI:
10.1016/j.pt.2018.11.012

18. MHC class I presented antigens from malignancies: A perspective on analytical characterization & immunogenicity

Author:
Schmidt, Maike; Lill, Jennie R.
Source:
Journal of proteomics 2019 v.191 pp. 48-57
ISSN:
1874-3919
Subject:
T-lymphocytes,   etc   ; antigens; immunogenicity; immunotherapy; major histocompatibility complex; neoplasms; peptides;     Show all 7 Subjects
Abstract:
... The field of cancer immunotherapy has expanded rapidly in the past few years, with many new approaches entering the clinic for T cell mediated killing of tumors. Several of these clinical approaches involve the exploitation of a CD8 + T cell response against MHC I presented tumor antigens. Here, we describe the types of tumor antigens which are considered as targets in the design of T cell based t ...
DOI:
10.1016/j.jprot.2018.04.021

19. Standardizing CAR-T therapy: Getting it scaled up

Author:
Dai, Xiaofeng; Mei, Yi; Cai, Dongyan; Han, Weidong
Source:
Biotechnology advances 2019 v.37 no.1 pp. 239-245
ISSN:
0734-9750
Subject:
T-lymphocytes,   etc   ; manufacturing; monoclonal antibodies; neoplasm cells; neoplasms; precision medicine;     Show all 6 Subjects
Abstract:
... CAR-T therapy, grafting the specificity of a monoclonal antibody onto a T cell to target certain cancer cells, has been recognized as a promising therapeutic approach for cancer control as evidenced by the two CAR-T products proved by FDA in 2017. However, the unique heterogeneity of CAR-T therapy has restricted its production in a limited number of institutions and made it a boutique oncotherapy. ...
DOI:
10.1016/j.biotechadv.2018.12.002

20. Fates of CD8+ T cells in Tumor Microenvironment

Author:
Maimela, Nomathamsanqa Resegofetse; Liu, Shasha; Zhang, Yi
Source:
Computational and Structural Biotechnology Journal 2019 v.17 pp. 1-13
ISSN:
2001-0370
Subject:
CD8-positive T-lymphocytes,   etc   ; biotechnology; cell growth; immunosuppression; neoplasms; prognosis;     Show all 6 Subjects
Abstract:
... Studies have reported a positive correlation between elevated CD8+ T cells in the tumor microenvironment (TME) and good prognosis in cancer. However, the mechanisms linking T cell tumor-infiltration and tumor rejection are yet to be fully understood. The cells and factors of the TME facilitate tumor development in various ways. CD8+ T cell function is influenced by a number of factors, including C ...
DOI:
10.1016/j.csbj.2018.11.004