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1. Regulatory B Cells: Dark Horse in Pregnancy Immunotherapy?

Author:
Guzman-Genuino, Ruth Marian; Hayball, John D.; Diener, Kerrilyn R.
Source:
Journal of molecular biology 2021 v.433 no.1 pp. 166596
ISSN:
0022-2836
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; dendritic cells; immunotherapy; pregnancy; reproductive system;     Show all 6 Subjects
Abstract:
... There are many unanswered questions surrounding the function of immune cells and how they interact with the reproductive system to support successful pregnancy or contribute to pregnancy pathologies. While the role of immune cells such as uterine natural killer and dendritic cells, and more recently regulatory T cells has been established, the role of another major immune cell population, the B ce ...
DOI:
10.1016/j.jmb.2020.07.008

2. Depletion of CD45RA+ T cells: Advantages and disadvantages of different purification methods

Author:
Bremm, Melanie; Krastel, Theresa; Cappel, Claudia; Zimmermann, Olga; Pfeffermann, Lisa-Marie; Katzki, Verena; Bonig, Halvard; Schäfer, Richard; Rettinger, Eva; Merker, Michael; Bremm, Sebastian; Schaefer, Kirsten; Klingebiel, Thomas; Soerensen, Jan; Bader, Peter; Huenecke, Sabine
Source:
Journal of immunological methods 2021 v.492 pp. 112960
ISSN:
0022-1759
Subject:
B-lymphocytes,   etc   ; cytotoxicity; stem cells;     Show all 3 Subjects
Abstract:
... Recently, new advances were made regarding the depletion of CD45RA⁺ naïve T cells from haploidentical grafts as they are suspected to be the most alloreactive.Within this project we investigated CD45RA-depletion from G-CSF mobilized PBSC by two different purification strategies according to GMP, specifically direct depletion of CD45RA⁺ cells (one-step approach), or CD34-positive selection followed ...
DOI:
10.1016/j.jim.2021.112960

3. LFA-1 cluster formation in T-cells depends on L-plastin phosphorylation regulated by P90RSK and PP2A

Author:
Wabnitz, Guido H.; Honus, Sibylle; Habicht, Jüri; Orlik, Christian; Kirchgessner, Henning; Samstag, Yvonne
Source:
Cellular and molecular life sciences 2021 v.78 no.7 pp. 3543-3564
ISSN:
1420-682X
Subject:
T-lymphocytes,   etc   ; dephosphorylation; integrins; phosphorylation;     Show all 4 Subjects
Abstract:
... The integrin LFA-1 is crucial for T-cell/ APC interactions and sensitive recognition of antigens. Precise nanoscale organization and valency regulation of LFA-1 are mandatory for an appropriate function of the immune system. While the inside-out signals regulating the LFA-1 affinity are well described, the molecular mechanisms controlling LFA-1 avidity are still not fully understood. Here, we show ...
DOI:
10.1007/s00018-020-03744-z

4. Narcissistic T cells: reactivity to self makes a difference

Author:
Paprckova, Darina; Stepanek, Ondrej
Source:
TheFEBS journal 2021 v.288 no.6 pp. 1778-1788
ISSN:
1742-464X
Subject:
T-lymphocytes,   etc   ; antigens; homeostasis; thymocytes;     Show all 4 Subjects
Abstract:
... It has been appreciated for more than three decades that the interactions between the T‐cell antigen receptor and self‐antigens are the major determinants of the cell fates of developing thymocytes and the establishment of central tolerance. However, recent evidence shows that the level of self‐reactivity substantially contributes to fate choices of positively selected mature T cells in homeostasi ...
DOI:
10.1111/febs.15498

5. Immune landscape and therapeutic strategies: new insights into PD-L1 in tumors

Author:
Wei, Yuan; Xiao, Xiao; Lao, Xiang-Ming; Zheng, Limin; Kuang, Dong-Ming
Source:
Cellular and molecular life sciences 2021 v.78 no.3 pp. 867-887
ISSN:
1420-682X
Subject:
T-lymphocytes,   etc   ; immunity; remission; therapeutics;     Show all 4 Subjects
Abstract:
... PD-1/PD-L1 axis represents an important target for renormalizing and resetting anti-tumor immunity in cancer patients. Currently, anti-PD-1/PD-L1 therapy has been applied in a broad spectrum of tumors and has yielded durable remission in patients. However, how to further broaden the application, guide personalized therapeutic strategies, and improve clinical responses remains a vital task. At pres ...
DOI:
10.1007/s00018-020-03637-1

6. LncRNAs in adaptive immunity: role in physiological and pathological conditions

Author:
Zeni, Pedro Faria; Mraz, Marek
Source:
RNA biology 2021 v.18 no.5 pp. 619-632
ISSN:
1555-8584
Subject:
B-lymphocytes; T-lymphocytes; lymphocyte proliferation,   etc   ; immune response; immunologic memory; inflammatory bowel disease; interferons; lymphoma; microRNA; rheumatoid arthritis; sclerosis;     Show all 11 Subjects
Abstract:
... The adaptive immune system is responsible for generating immunological response and immunological memory. Regulation of adaptive immunity including B cell and T cell biology was mainly understood from the protein and microRNA perspective. However, long non-coding RNAs (lncRNAs) are an emerging class of non-coding RNAs (ncRNAs) that influence key factors in lymphocyte biology such as NOTCH, PAX5, M ...
DOI:
10.1080/15476286.2020.1838783

7. MTOR Signaling and Metabolism in Early T Cell Development

Author:
Werlen, Guy; Jain, Ritika; Jacinto, Estela
Source:
Genes 2021 v.12 no.5
ISSN:
2073-4425
Subject:
T-lymphocytes,   etc   ; immunosuppression; metabolism; rapamycin; thymocytes;     Show all 5 Subjects
Abstract:
... The mechanistic target of rapamycin (mTOR) controls cell fate and responses via its functions in regulating metabolism. Its role in controlling immunity was unraveled by early studies on the immunosuppressive properties of rapamycin. Recent studies have provided insights on how metabolic reprogramming and mTOR signaling impact peripheral T cell activation and fate. The contribution of mTOR and met ...
DOI:
10.3390/genes12050728

8. Transcription factors regulate early T cell development via redeployment of other factors: Functional dynamics of constitutively required factors in cell fate decisions

Author:
Hosokawa, Hiroyuki; Masuhara, Kaori; Koizumi, Maria
Source:
BioEssays 2021 v.43 no.5 pp. e2000345
ISSN:
0265-9247
Subject:
T-lymphocytes,   etc   ; chromatin; gene expression; genomics; multiomics;     Show all 5 Subjects
Abstract:
... Establishment of cell lineage identity from multipotent progenitors is controlled by cooperative actions of lineage‐specific and stably expressed transcription factors, combined with input from environmental signals. Lineage‐specific master transcription factors activate and repress gene expression by recruiting consistently expressed transcription factors and chromatin modifiers to their target l ...
DOI:
10.1002/bies.202000345

9. Transcriptional and epigenetic regulation of PD-1 expression

Author:
Chi, Zengde; Lu, Yan; Yang, Yinlong; Li, Bingqing; Lu, Peiyuan
Source:
Cellular and molecular life sciences 2021 v.78 no.7 pp. 3239-3246
ISSN:
1420-682X
Subject:
T-lymphocytes,   etc   ; autoimmunity; epigenetics; neoplasms; transcription (genetics);     Show all 5 Subjects
Abstract:
... Programmed cell death-1 (PD-1) is a co-inhibitory receptor that plays important roles in regulating T cell immunity and peripheral tolerance. PD-1 signaling prevents T cells from overactivation during acute infections, but it maintains T cell exhaustion during chronic infections. Tumor cells can exploit the PD-1 signaling pathway to evade antitumor immune responses. The PD-1 signaling pathway is a ...
DOI:
10.1007/s00018-020-03737-y

10. Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities

Author:
Lee, Li-Yen; Hew, Geena Suet Yin; Mehta, Meenu; Shukla, Shakti D.; Satija, Saurabh; Khurana, Navneet; Anand, Krishnan; Dureja, Harish; Singh, Sachin Kumar; Mishra, Vijay; Singh, Pankaj Kumar; Gulati, Monica; Prasher, Parteek; Aljabali, Alaa A.A.; Tambuwala, Murtaza M.; Thangavelu, Lakshmi; Panneerselvam, Jithendra; Gupta, Gaurav; Zacconi, Flavia C.; Shastri, Madhur; Jha, Niraj Kumar; Xenaki, Dikaia; MacLoughlin, Ronan; Oliver, Brian G.; Chellappan, Dinesh Kumar; Dua, Kamal
Source:
Life sciences 2021 v.267 pp. 118973
ISSN:
0024-3205
Subject:
T-lymphocytes,   etc   ; cytokines; eosinophils; immune response; therapeutics;     Show all 5 Subjects
Abstract:
... Eosinophils are bi-lobed, multi-functional innate immune cells with diverse cell surface receptors that regulate local immune and inflammatory responses. Several inflammatory and infectious diseases are triggered with their build up in the blood and tissues. The mobilization of eosinophils into the lungs is regulated by a cascade of processes guided by Th2 cytokine generating T-cells. Recruitment ...
DOI:
10.1016/j.lfs.2020.118973

11. Epidermal resident γδ T cell development and function in skin

Author:
Xu, Yingping; Dimitrion, Peter; Cvetkovski, Steven; Zhou, Li; Mi, Qing-Sheng
Source:
Cellular and molecular life sciences 2021 v.78 no.2 pp. 573-580
ISSN:
1420-682X
Subject:
T-lymphocytes,   etc   ; epigenetics; homeostasis; transcription (genetics);     Show all 4 Subjects
Abstract:
... Epidermal resident γδ T cells, or dendritic epidermal T cells (DETCs) in mice, are a unique and conserved population of γδ T cells enriched in the epidermis, where they serve as the regulators of immune responses and sense skin injury. Despite the great advances in the understanding of the development, homeostasis, and function of DETCs in the past decades, the origin and the underlying molecular ...
DOI:
10.1007/s00018-020-03613-9

12. Lymphocyte transformation test: History and current approaches

Author:
Sachs, Bernhardt; Fatangare, Amol; Sickmann, Albert; Glässner, Andreas
Source:
Journal of immunological methods 2021 v.493 pp. 113036
ISSN:
0022-1759
Subject:
T-lymphocytes; lymphocyte proliferation,   etc   ; antibodies; cell culture; cell proliferation; drugs; hypersensitivity; memory; patients; radiolabeling; thymidine;     Show all 11 Subjects
Abstract:
... Drug-induced hypersensitivity reactions encompass a variety of different clinical phenotypes ranging from harmless rashes to fatal reactions. They can be classified into allergic (i.e. drug allergy) and non-allergic reactions (i.e. non-allergic hypersensitivity). Drug allergies in turn can either be antibody (e.g. IgE) or T cell-mediated.One of the diagnostic tools for the in vitro detection of dr ...
DOI:
10.1016/j.jim.2021.113036

13. Chlamydia trachomatis: Cell biology, immunology and vaccination

Author:
Murray, Sam M.; McKay, Paul F.
Source:
Vaccine 2021 v.39 no.22 pp. 2965-2975
ISSN:
0264-410X
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; Chlamydia trachomatis; disease severity; immune evasion; immunity; pathogens; vaccination; vaccine development; vaccines;     Show all 10 Subjects
Abstract:
... Chlamydia trachomatis is the causative agent of a highly prevalent sexually transmitted bacterial disease and is associated with a number of severe disease complications. Current therapy options are successful at treating disease, but patients are left without protective immunity and do not benefit the majority asymptomatic patients who do not seek treatment. As such, there is a clear need for a b ...
DOI:
10.1016/j.vaccine.2021.03.043

14. Variable immunogenicity of a vivax malaria blood-stage vaccine candidate

Author:
De, Sai Lata; May, Samuel; Shah, Keshav; Slawinski, Michelle; Changrob, Siriruk; Xu, Shulin; Barnes, Samantha J.; Chootong, Patchanee; Ntumngia, Francis B.; Adams, John H.
Source:
Vaccine 2021 v.39 no.19 pp. 2668-2675
ISSN:
0264-410X
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; Culicidae; Plasmodium vivax; durability; immunogenicity; malaria; memory; public health; tropical diseases; vaccines;     Show all 11 Subjects
Abstract:
... Relapsing malaria caused by Plasmodium vivax is a neglected tropical disease and an important cause of malaria worldwide. Vaccines to prevent clinical disease and mosquito transmission of vivax malaria are needed to overcome the distinct challenges of this important public health problem. In this vaccine immunogenicity study in mice, we examined key variables of responses to a P. vivax Duffy bindi ...
DOI:
10.1016/j.vaccine.2021.03.072

15. Driving CARs with alternative navigation tools – the potential of engineered binding scaffolds

Author:
Zajc, Charlotte U.; Salzer, Benjamin; Taft, Joseph M.; Reddy, Sai T.; Lehner, Manfred; Traxlmayr, Michael W.
Source:
TheFEBS journal 2021 v.288 no.7 pp. 2103-2118
ISSN:
1742-464X
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; amino acids; antigens; immunogenicity; ligands; neoplasms; oligomerization; risk;     Show all 9 Subjects
Abstract:
... T cells that are genetically engineered to express chimeric antigen receptors (CAR T cells) have shown impressive clinical efficacy against B‐cell malignancies. In contrast to these highly potent CD19‐targeting CAR T cells, many of those directed against other tumor entities and antigens currently suffer from several limitations. For example, it has been demonstrated that many scFvs used as antige ...
DOI:
10.1111/febs.15523

16. Differential roles of miR‐15a/16‐1 and miR‐497/195 clusters in immune cell development and homeostasis

Author:
Hutter, Katharina; Rülicke, Thomas; Drach, Mathias; Andersen, Lill; Villunger, Andreas; Herzog, Sebastian
Source:
TheFEBS journal 2021 v.288 no.5 pp. 1533-1545
ISSN:
1742-464X
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; ; embryogenesis; genes; hematopoiesis; homeostasis; longevity; lymphocytic leukemia; mice; microRNA; phenotype;     Show all 12 Subjects
Abstract:
... MicroRNAs (miRNAs) post‐transcriptionally repress almost all genes in mammals and thereby form an additional layer of gene regulation. As such, miRNAs impact on nearly every physiological process and have also been associated with cancer. Prominent examples of such miRNAs can be found in the miR‐15 family, composed of the bicistronic clusters miR‐15a/16‐1, miR‐15b/16‐2, and miR‐497/195. In particu ...
DOI:
10.1111/febs.15493

17. Distinct Features of Germinal Center Reactions in Macaques Infected by SIV or Vaccinated with a T-Dependent Model Antigen

Author:
Trovato, Maria; Ibrahim, Hany M.; Isnard, Stephane; Le Grand, Roger; Bosquet, Nathalie; Borhis, Gwenoline; Richard, Yolande
Source:
Viruses 2021 v.13 no.2
ISSN:
1999-4915
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; antibody affinity; apoptosis; cytotoxicity; inflammation; lymph; lymph nodes; spleen; tetanus;     Show all 10 Subjects
Abstract:
... B-cell follicles constitute large reservoirs of infectious HIV/SIV associated to follicular dendritic cells and infecting follicular helper (TFH) and regulatory (TFR) T-cells in germinal centers (GCs). Thus, follicular and GC B-cells are persistently exposed to viral antigens. Despite recent development of potent HIV immunogens, numerous questions are still open regarding GC reaction during early ...
DOI:
10.3390/v13020263

18. TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes

Author:
Japp, Alberto Sada; Meng, Wenzhao; Rosenfeld, Aaron M.; Perry, Daniel J.; Thirawatananond, Puchong; Bacher, Rhonda L.; Liu, Chengyang; Gardner, Jay S.; Atkinson, Mark A.; Kaestner, Klaus H.; Brusko, Todd M.; Naji, Ali; Luning Prak, Eline T.; Betts, Michael R.
Source:
Cell 2021 v.184 no.3 pp. 827-839.e14
ISSN:
0092-8674
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; flow cytometry; insulin-dependent diabetes mellitus; paper;     Show all 5 Subjects
Abstract:
... Ahmed and colleagues recently described a novel hybrid lymphocyte expressing both a B and T cell receptor, termed double expresser (DE) cells. DE cells in blood of type 1 diabetes (T1D) subjects were present at increased numbers and enriched for a public B cell clonotype. Here, we attempted to reproduce these findings. While we could identify DE cells by flow cytometry, we found no association bet ...
DOI:
10.1016/j.cell.2020.11.035

19. B-Cell Control of Regulatory T Cells in Friend Virus Infection

Author:
Moore, Tyler C.; Hasenkrug, Kim J.
Source:
Journal of molecular biology 2021 v.433 no.1 pp. 166583
ISSN:
0022-2836
Subject:
B-lymphocytes; CD8-positive T-lymphocytes,   etc   ; antibodies; antibody formation; antigen-presenting cells; models;     Show all 6 Subjects
Abstract:
... B lymphocytes have well-established effector roles during viral infections, including production of antibodies and functioning as antigen-presenting cells for CD4+ and CD8+ T cells. B cells have also been shown to regulate immune responses and induce regulatory T cells (Tregs). In the Friend virus (FV) model, Tregs are known to inhibit effector CD8+ T-cell responses and contribute to virus persist ...
DOI:
10.1016/j.jmb.2020.06.022

20. Implementation of in silico methods to predict common epitopes for vaccine development against Chikungunya and Mayaro viruses

Author:
Hoque, Hammadul; Islam, Rahatul; Ghosh, Srijon; Rahaman, Md. Mashiur; Jewel, Nurnabi Azad; Miah, Md. Abunasar
Source:
Heliyon 2021 v.7 no.3 pp. e06396
ISSN:
2405-8440
Subject:
B-lymphocytes; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes,   etc   ; Chikungunya virus; Mayaro virus; Neotropics; computer simulation; epitopes; immunoinformatics; peptides; polyproteins; vaccine development; vaccines;     Show all 13 Subjects
Abstract:
... Being a Positive sense RNA virus the recent reemergence of Chikungunya and Mayaro virus has taken the concern of the leading scientific communities of the world. Though the outbreak of Mayaro virus is limited to Neotropical region only, Chikungunya is already identified in over 60 countries around the world. Besides, the lack of a strong protective treatment, misdiagnosis issue and co-circulation ...
DOI:
10.1016/j.heliyon.2021.e06396