PubAg

Main content area

You searched for: Subject "lymphocytes" Remove constraint Subject: "lymphocytes"
Start Over

Search

19,777  Search Results

« Previous | 1 - 20 of 19,777 |
Number of results to display per page

Search Results

1. γδ TCR Recognition of MR1: Adapting to Life on the Flip Side

Author:
Willcox, Benjamin E.; Mohammed, Fiyaz; Willcox, Carrie R.
Source:
Trends in biochemical sciences 2020 v.45 no.7 pp. 551-553
ISSN:
0968-0004
Subject:
T-lymphocytes,   etc   ; humans; ligands;     Show all 3 Subjects
Abstract:
... Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised by the αβ-TCR of mucosal associated invariant T cells, MR1 interacts with specific γδ-TCRs using strikingly diverse binding modes, suggesting fundamental diff ...
DOI:
10.1016/j.tibs.2020.03.012

2. Chemotherapy Induces Cancer-Fighting B Cells

Author:
Liu, Zhida; Fu, Yang-Xin
Source:
Cell 2020 v.180 no.6 pp. 1037-1039
ISSN:
0092-8674
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; complement; drug therapy; immunity; neoplasms;     Show all 6 Subjects
Abstract:
... Tumor-infiltrating B cells are heterogeneous, and their roles in tumor immunity are controversial. In this issue of Cell, Lu and colleagues demonstrate that chemotherapy-induced complement signals promote the generation of ICOSL⁺B cells, which enhance tumor-specific T cell responses. ...
DOI:
10.1016/j.cell.2020.02.046

3. PD-1: A Driver or Passenger of T Cell Exhaustion?

Author:
He, Xing; Xu, Chenqi
Source:
Molecular cell 2020 v.77 no.5 pp. 930-931
ISSN:
1097-2765
Subject:
T-lymphocytes,   etc   ; antigens; cytokines; genes;     Show all 4 Subjects
Abstract:
... Okazaki and colleagues report that PD-1 signaling mainly restrains effector function at the early stage of T cell activation. The authors find that cytokine genes require strong antigen stimulation and are more susceptible to PD-1 inhibition. ...
DOI:
10.1016/j.molcel.2020.02.013

4. It’s Hard to Teach an Old B Cell New Tricks

Author:
Guthmiller, Jenna J.; Wilson, Patrick C.
Source:
Cell 2020 v.180 no.1 pp. 18-20
ISSN:
0092-8674
Subject:
B-lymphocytes,   etc   ; lymph nodes; translation (genetics);     Show all 3 Subjects
Abstract:
... Victora and colleagues challenge current perceptions that memory B cells readily participate in secondary germinal center reactions, allowing further modification of specificity upon reactivation. Rather, naïve B cells are the predominant B cell type that populate secondary germinal centers. This work has important basic immunological and translational implications. ...
DOI:
10.1016/j.cell.2019.12.019

5. Downregulation of GPR183 on infection restricts the early infection and intracellular replication of mycobacterium tuberculosis in macrophage

Author:
Tang, Jun; Shi, Ya'nan; Zhan, Lingjun; Qin, Chuan
Source:
Microbial pathogenesis 2020 v.145 pp. 104234
ISSN:
0882-4010
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; Mycobacterium tuberculosis; antagonists; chemotaxis; ligands; macrophages; mutational analysis;     Show all 8 Subjects
Abstract:
... GPR183/EBI2 is a key chemotactic receptor for the positioning of B cells in lymphoid organs, and also for the migration of T cells and other immune cells. Here, we demonstrate that the downregulation of GPR183 in macrophage induced during Mtb infection restrains the bacterial early infection and intracellular replication. Overexpression of GPR183 or stimulation with its natural ligand favors Mtb r ...
DOI:
10.1016/j.micpath.2020.104234

6. B-Cell Control of Regulatory T Cells in Friend Virus Infection

Author:
Moore, Tyler C.; Hasenkrug, Kim J.
Source:
Journal of molecular biology 2020
ISSN:
0022-2836
Subject:
B-lymphocytes; CD8-positive T-lymphocytes,   etc   ; antibodies; antibody formation; antigen-presenting cells; models;     Show all 6 Subjects
Abstract:
... B lymphocytes have well-established effector roles during viral infections, including production of antibodies and functioning as antigen-presenting cells for CD4+ and CD8+ T cells. B cells have also been shown to regulate immune responses and induce regulatory T cells (Tregs). In the Friend virus (FV) model, Tregs are known to inhibit effector CD8+ T-cell responses and contribute to virus persist ...
DOI:
10.1016/j.jmb.2020.06.022

7. The effects of local irradiation on circulating lymphocytes in dogs receiving fractionated radiotherapy

Author:
Kent, Michael S.; Emami, Shaheen; Rebhun, Rob; Theon, Alain; Hansen, Katherine; Sparger, Ellen
Source:
Veterinary and comparative oncology 2020 v.18 no.2 pp. 191-198
ISSN:
1476-5810
Subject:
lymphocyte count; lymphocytes,   etc   ; adjuvants; adverse effects; dogs; fractionation; immunosuppression; immunotherapy; irradiation; neoplasms; patients; radiotherapy; retrospective studies;     Show all 13 Subjects
Abstract:
... Localized radiation therapy can be an effective treatment for cancer but is associated with localized and systemic side effects. Several studies have noted changes in complete blood count (CBC) parameters including decreases in the absolute lymphocyte count (ALC) and increases in the neutrophil:lymphocyte ratio (NLR). These changes could reflect immunosuppression and may contribute to decreased ef ...
DOI:
10.1111/vco.12531

8. CellTrace Violet™ inhibits equine lymphocyte proliferation

Author:
J. Lacy, Kamm; Parlane, Natalie A.; Riley, Christopher B.; Gee, Erica K.; Roberts, Joanna M.; McIlwraith, C. Wayne
Source:
Veterinary immunology and immunopathology 2020 v.223 pp. 110037
ISSN:
0165-2427
Subject:
lymphocyte proliferation; lymphocytes,   etc   ; Phytolaccaceae; cell proliferation; flow cytometry; fluorescent dyes; horses; microscopy; mitogens; thymidine; tritium; viability;     Show all 12 Subjects
Abstract:
... CellTrace Violet™ is a commonly used fluorescent dye used with flow cytometry to identify cell proliferation. Activated equine lymphocytes were examined using flow cytometry, microscopy and tritiated thymidine proliferation assays. CellTrace Violet™ was incorporated into the equine lymphocytes effectively. Equine lymphocytes proliferated when activated with pokeweed mitogen, but did not proliferat ...
DOI:
10.1016/j.vetimm.2020.110037

9. Presence of CD3+ and CD79a+ Lymphocytes in the Pituitary Gland of Dogs at Post-mortem Examination

Author:
Blomqvist, M.A.; Ley, C.; Karlsson, H.K.; Hanson, J.M.
Source:
Journal of comparative pathology 2020 v.176 pp. 116-121
ISSN:
0021-9975
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; antibodies; dogs; eosin; horses; immunohistochemistry; immunomodulation; necropsy; pituitary gland;     Show all 10 Subjects
Abstract:
... Hypophysitis has been reported occasionally in dogs, with most cases resembling primary lymphocytic hypophysitis in man. Although it is generally assumed that lymphocytes are not present normally in the canine pituitary gland, few studies have investigated this hypothesis. However, lymphocytes are recognized in the pituitary gland of people and horses without signs of pituitary disease. It is unkn ...
DOI:
10.1016/j.jcpa.2020.02.010

10. Current challenges and emerging opportunities of CAR-T cell therapies

Author:
Abreu, Teresa R.; Fonseca, Nuno A.; Gonçalves, Nélio; Moreira, João Nuno
Source:
Journal of controlled release 2020 v.319 pp. 246-261
ISSN:
0168-3659
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; antigens; antineoplastic activity; immunosuppression; immunotherapy; lymphoma; patients; remission;     Show all 9 Subjects
Abstract:
... Infusion of chimeric antigen receptor (CAR)-genetically modified T cells (CAR-T cells) have led to remarkable clinical responses and cancer remission in patients suffering from relapsed or refractory B-cell malignancies. This is a new form of adoptive T cell therapy (ACT), whereby the artificial CAR enables the redirection of T cells endogenous antitumor activity towards a predefined tumor-associa ...
DOI:
10.1016/j.jconrel.2019.12.047

11. CD70-mediated CD27 expression downregulation contributed to the regulatory B10 cell impairment in rheumatoid arthritis

Author:
Shi, Lianjie; Hu, Fanlei; Zhu, Lei; Xu, Chuanhui; Zhu, Huaqun; Li, Yingni; Liu, Hongjiang; Li, Chun; Liu, Na; Xu, Liling; Mu, Rong; Li, Zhanguo
Source:
Molecular immunology 2020 v.119 pp. 92-100
ISSN:
0161-5890
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; antibodies; interleukin-10; pathogenesis; patients; phenotype; rheumatoid arthritis;     Show all 8 Subjects
Abstract:
... Regulatory B10 cells have been shown to exhibit impaired functions in autoimmune diseases. However, the underlying mechanism is still obscure. In the present study, we aimed to understand the regulatory characteristics of regulatory B10 cells and how these cells are involved in the development of rheumatoid arthritis (RA). Here, we chose CD19⁺CD24ʰⁱCD27⁺ as the phenotype of regulatory B10 cells. W ...
DOI:
10.1016/j.molimm.2020.01.016

12. PD-L1+ regulatory B cells act as a T cell suppressor in a PD-L1-dependent manner in melanoma patients with bone metastasis

Author:
Wu, Hao; Xia, Liming; Jia, Dongdong; Zou, Hanhui; Jin, Gu; Qian, Wenkang; Xu, Haichao; Li, Tao
Source:
Molecular immunology 2020 v.119 pp. 83-91
ISSN:
0161-5890
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; immunoglobulin M; melanoma; metastasis; patients; phenotype; survival rate;     Show all 8 Subjects
Abstract:
... The five-year survival rate of melanoma worsens significantly with advancing tumor stage. We hypothesized that regulatory B cells (Breg) might have participated in the pathogenesis of melanoma. In this study, the PD-L1⁺ Breg cells were investigated. The expression of PD-L1 by circulating B cells was very low in healthy controls. In melanoma patients, on the other hand, the expression of PD-L1 by c ...
DOI:
10.1016/j.molimm.2020.01.008

13. Differences in the relative counts of peripheral blood lymphocyte subsets in various age groups of pigs

Author:
Pietrasina, Olga; Miller, Julia; Rzasa, Anna
Source:
Canadian journal of veterinary research 2020 v.84 no.1 pp. 52-59
ISSN:
0830-9000
Subject:
B-lymphocytes; T-lymphocytes,   etc   ; adults; cytotoxicity; gilts; immune response; sows; veterinary medicine;     Show all 8 Subjects
Abstract:
... The aim of the study was to determine age-related changes in peripheral blood lymphocytes in pigs. Previous studies looking at age-related differences in lymphocyte subsets in porcine blood have not established reference ranges for these parameters. Moreover, most studies have concentrated on the dynamic changes in the first months of life, failing to continue observations in older animals. Theref ...

14. The elusive identity of CXCR5+ CD8 T cells in viral infection and autoimmunity: Cytotoxic, regulatory, or helper cells?

Author:
Fousteri, Georgia; Kuka, Mirela
Source:
Molecular immunology 2020 v.119 pp. 101-105
ISSN:
0161-5890
Subject:
B-lymphocytes; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes,   etc   ; autoantibodies; autoimmunity; cytotoxicity; functional properties; genes; humoral immunity; immunomodulation; mutation; phenotype;     Show all 12 Subjects
Abstract:
... Our knowledge on the development and functions of CXCR5⁺ CD8 T cells is rudimentary when confronted to other extensively studied CD8 T cell subsets. A decade ago, it became apparent that CD8 T cells possess two additional and rather unexpected functional properties other than cytotoxicity, one involving what is known as B cell helper activity and the other involving suppression of self-reactive re ...
DOI:
10.1016/j.molimm.2020.01.007

15. Immunomodulatory activities of sulfated Cyclocarya paliurus polysaccharides with different degrees of substitution on mouse spleen lymphocytes

Author:
Yu, Yue; Song, Qianqian; Huang, Lixin; Shen, Mingyue; Yu, Qiang; Chen, Yi; Xie, Jianhua
Source:
Journal of functional foods 2020 v.64 pp. 103706
ISSN:
1756-4646
Subject:
B-lymphocytes; T-lymphocytes; lymphocyte proliferation,   etc   ; Cyclocarya paliurus; cell proliferation; concanavalin A; cytokines; immunomodulators; mice; molecular weight; polysaccharides; secretion; spleen; splenocytes;     Show all 14 Subjects
Abstract:
... Two sulfated polysaccharides SCP3 and SCP5 with degree of substitution (DS) 0.45 and 0.13 were obtained by modifying the Cyclocarya paliurus polysaccharide (CP) with chlorosulfonic acid-pyridine method. Results demonstrated that the physicochemical properties, molar ratios of monosaccharide composition, molecular weights, and in vitro immunomodulatory activity were changed after being sulfated. Sp ...
DOI:
10.1016/j.jff.2019.103706

16. Immunophenotypic characterization and clinical outcome in cats with lymphocytosis

Author:
Rout, Emily D.; Labadie, Julia D.; Curran, Kaitlin M.; Yoshimoto, Janna A.; Avery, Anne C.; Avery, Paul R.
Source:
Journal of veterinary internal medicine 2020 v.34 no.1 pp. 105-116
ISSN:
0891-6640
Subject:
B-lymphocytes; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes,   etc   ; antigens; cats; disease course; females; flow cytometry; gene rearrangement; intestines; lymphatic diseases; medical records; phenotype; retrospective studies;     Show all 14 Subjects
Abstract:
... BACKGROUND: Lymphocytosis is relatively common in cats, but few studies describe lymphocyte populations or the clinical course associated with different immunophenotypic expansions. HYPOTHESIS/OBJECTIVES: We hypothesized that cats frequently develop non‐neoplastic lymphocytosis and that different neoplastic immunophenotypes have variable prognoses. We aimed to characterize the lymphocyte expansion ...
DOI:
10.1111/jvim.15650
PubMed:
31693230
PubMed Central:
PMC6979106

17. Lymphocyte Populations in the Adventitial Layer of Hydatid Cysts in Cattle: Relationship With Cyst Fertility Status and Fasciola Hepatica Co-Infection

Author:
Jiménez, Mauricio; Stoore, Caroll; Hidalgo, Christian; Corrêa, Felipe; Hernández, Marcela; Benavides, J.; Ferreras, M. C.; Sáenz, Leonardo; Paredes, Rodolfo
Source:
Veterinary pathology 2020 v.57 no.1 pp. 108-114
ISSN:
1544-2217
Subject:
B-lymphocytes; T-lymphocytes; lymphocyte count,   etc   ; Echinococcus granulosus; Fasciola hepatica; animal pathology; cattle; echinococcosis; hydatids; immune response; intermediate hosts; liver; lungs; mast cells; mixed infection; parasites; protoscoleces; zoonoses;     Show all 18 Subjects
Abstract:
... Cystic echinococcosis is a worldwide zoonosis caused by the cestode Echinococcus granulosus. Two types of hydatid cysts occur in intermediate hosts: fertile cysts that generate protoscoleces from the germinal layer of the cyst, and infertile cysts that do not produce protoscoleces and are unable to continue the life cycle of the parasite. The adventitial layer, a host-derived fibrous capsule surro ...
DOI:
10.1177/0300985819875721

18. Biotechnologies to tackle the challenge of neoantigen identification

Author:
Arnaud, Marion; Duchamp, Margaux; Bobisse, Sara; Renaud, Philippe; Coukos, George; Harari, Alexandre
Source:
Current opinion in biotechnology 2020 v.65 pp. 52-59
ISSN:
0958-1669
Subject:
T-lymphocytes,   etc   ; biotechnology; cancer therapy; immunotherapy; neoplasms; screening;     Show all 6 Subjects
Abstract:
... Among immune correlates of clinical responses, tumor-specific neoantigens took the spotlight as relevant targets for cancer immunotherapy. The implementation of pipelines for personalized cancer therapy remains challenging due to the privacy, that is patient-specificity, of neoantigens and the low-frequency of neoantigen-specific T cells in blood and tumor samples. To overcome these obstacles, rec ...
DOI:
10.1016/j.copbio.2019.12.014

19. Bispecific antibodies in cancer immunotherapy

Author:
Rader, Christoph
Source:
Current opinion in biotechnology 2020 v.65 pp. 9-16
ISSN:
0958-1669
Subject:
T-lymphocytes,   etc   ; antibodies; antigens; immunotherapy; innate immunity; neoplasms; toxicity;     Show all 7 Subjects
Abstract:
... Among antibody-based cancer therapies, bispecific antibodies (biAbs) have gained momentum in preclinical and clinical investigations following the regulatory approvals of the trailblazing T-cell engaging biAb (T-biAb) blinatumomab. Discussed herein are recent strategies that aim at boosting the potency and mitigating the toxicity of T-biAbs, broadening their therapeutic utility from hematologic to ...
DOI:
10.1016/j.copbio.2019.11.020

20. Hepatosplenic phagocytic cells indirectly contribute to anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes: Appearance of an unexplained mechanism in the ABC phenomenon

Author:
El Sayed, Marwa Mohamed; Takata, Haruka; Shimizu, Taro; Kawaguchi, Yoshino; Abu Lila, Amr S.; Elsadek, Nehal E.; Alaaeldin, Eman; Ishima, Yu; Ando, Hidenori; Kamal, Amal; Sarhan, Hatem A.; Ishida, Tatsuhiro
Source:
Journal of controlled release 2020 v.323 pp. 102-109
ISSN:
0168-3659
Subject:
B-lymphocytes,   etc   ; adverse effects; anaphylaxis; immunoglobulin M; mice; models; phagocytes;     Show all 7 Subjects
Abstract:
... The accelerated blood clearance (ABC) phenomenon, caused in large degree via in vivo anti-PEG IgM production, is one of obstacles for development of PEGylated liposome and protein formulations, due to decreased efficiency and/or side effects such as anaphylaxis upon repeat administrations. We have shown in murine ABC models that splenectomy suppressed the level of anti-PEG IgM production induced b ...
DOI:
10.1016/j.jconrel.2020.04.011