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You searched for: Subject "major histocompatibility complex" Remove constraint Subject: "major histocompatibility complex"
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1. Do ectoparasites on fish gills “talk” with gut microbiota far away?

Author:
Lin Wang; Defeng Zhang; Jun Xie; Ouqin Chang; Qing Wang; Cunbin Shi; Fei Zhao; Hua Gong; Yan Ren; Najiah Musa; Kok Leong Lee; Houjun Pan
Source:
Aquaculture 2023 v.562 pp. 738880
ISSN:
0044-8486
Subject:
major histocompatibility complex,   etc   ; Bacteroides; Ctenopharyngodon idella; Dactylogyrus; Toll-like receptor 3; antioxidants; aquaculture; ectoparasites; fish; glutathione peroxidase; histopathology; immunoglobulins; intestinal microorganisms; intestines;     Show all 14 Subjects
Abstract:
... The ectoparasites Dactylogyrus lamellatus usually infest fish gills and cause severe damage to the gill tissues of the host. However, whether the ectoparasites influence gut microbiota is still unknown. In this study, gut microbiota combined with histopathological characteristics, biochemical parameters, and relative expression of immune-related genes were analyzed in grass carp severely infected ...
DOI:
10.1016/j.aquaculture.2022.738880

2. Molecular characterization, expression patterns, and subcellular localization of a classical and a novel nonclassical MHC class I α molecules from Japanese eel Anguilla japonica

Author:
Jianjun Feng; Xinwei Peng; Peng Lin; Yilei Wang; Ziping Zhang; Yuankai Xu; Pengyun Chen; Jingying Wu
Source:
Aquaculture and fisheries 2023 v.8 no.2 pp. 108-123
ISSN:
2468-550X
Subject:
major histocompatibility complex,   etc   ; Aeromonas hydrophila; Anguilla japonica; amino acid sequences; aquaculture; bacterial infections; cytoplasm; fish; glycosylation; humans; immune response; intestines; kidneys; liver; phylogeny; polyinosinic-polycytidylic acid; quantitative polymerase chain reaction; spleen;     Show all 18 Subjects
Abstract:
... Major histocompatibility complex (MHC) molecules play a critical role in the immune response of vertebrate animals by presenting foreign antigens to T lymphocytes. In this study, we first cloned and identified a classical and a novel nonclassical MHC I α molecules from Japanese eel (Anguilla japonica), named as AjMHC I-UBA and AjMHC I-L, respectively. The full-length cDNA of AjMHC I-UBA contains a ...
DOI:
10.1016/j.aaf.2021.08.005

3. Partial Dissociation of Antigenic Peptides from MHC I -- Linking NMR Data to Microstates Observed in MD Simulations

Author:
Sebastian Wingbermuehle; Lars Schaefer
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
major histocompatibility complex,   etc   ; Gibbs free energy; molecular dynamics; peptides; temperature;     Show all 5 Subjects
Abstract:
... Although several crystal structures of Major Histocompatibility Complex I (MHC I) binding an antigenic peptide (pMHC I) have been solved, the structural dynamics of pMHC I at the cell surface remain largely elusive. According to a recent NMR study on HLA-B*35:01 (Yanaka et al., J. Biol. Chem., 2014), pMHC I complexes can adopt a minor state in which the antigenic peptide is bound tightly to MHC I ...
DOI:
10.1016/j.molimm.2022.05.047

4. Using molecular dynamics simulations to interrogate T cell receptor non-equilibrium kinetics

Author:
Zachary A. Rollins; Roland Faller; Steven C. George
Source:
Computational and Structural Biotechnology Journal 2022 v.20 pp. 2124-2133
ISSN:
2001-0370
Subject:
major histocompatibility complex,   etc   ; T-lymphocytes; antigens; biotechnology; hydrogen; molecular dynamics; peptides;     Show all 7 Subjects
Abstract:
... An atomic-scale mechanism of T Cell Receptor (TCR) mechanosensing of peptides in the binding groove of the peptide-major histocompatibility complex (pMHC) may inform the design of novel TCRs for immunotherapies. Using steered molecular dynamics simulations, our study demonstrates that mutations to peptides in the binding groove of the pMHC – which are known to discretely alter the T cell response ...
DOI:
10.1016/j.csbj.2022.04.018

5. Novel insights on aquatic mammal MHC evolution: Evidence from manatee DQB diversity

Author:
André Luiz Alves de Sá; Pamela Ketrya Barreiros Baker; Breanna Breaux; Jairo Moura Oliveira; Alex Garcia Cavalleiro de Macedo Klautau; Kristian Legatzki; Fábia de Oliveira Luna; Fernanda Löffler Niemeyer Attademo; Margaret Elizabeth Hunter; Michael Frederick Criscitiello; Maria Paula Cruz Schneider; Leonardo dos Santos Sena
Source:
Developmental and comparative immunology 2022 v.132 pp. 104398
ISSN:
0145-305X
Subject:
major histocompatibility complex,   etc   ; Sirenia; evolution; genetic distance; immune system; marine mammals; pathogens;     Show all 7 Subjects
Abstract:
... The low diversity in marine mammal major histocompatibility complex (MHC) appears to support the hypothesis of reduced pathogen selective pressure in aquatic systems compared to terrestrial environments. However, the lack of characterization of the aquatic and evolutionarily distant Sirenia precludes drawing more generalized conclusions. Therefore, we aimed to characterize the MHC DQB diversity of ...
DOI:
10.1016/j.dci.2022.104398

6. Performance Comparison of Different Approaches in Genotyping MHC-DRB: The Contrast between Single-Locus and Multi-Locus Species

Author:
Ida Svetličić; Dean Konjević; Elena Bužan; Miljenko Bujanić; Luka Duniš; Sunčica Stipoljev; Jelena Martinčić; Mihaela Šurina; Ana Galov
Source:
Animals 2022 v.12 no.18 pp. -
ISSN:
2076-2615
Subject:
major histocompatibility complex,   etc   ; Capreolus capreolus; Cervus elaphus; alleles; bioinformatics; genotyping; loci; wildlife;     Show all 8 Subjects
Abstract:
... Major histocompatibility complex (MHC) genes are widely recognised as valuable markers for wildlife genetic studies given their extreme polymorphism and functional importance in fitness-related traits. Newly developed genotyping methods, which rely on the use of next-generation sequencing (NGS), are gradually replacing traditional cloning and Sanger sequencing methods in MHC genotyping studies. Al ...
DOI:
10.3390/ani12182452

7. Evolution and molecular interactions of major histocompatibility complex (MHC)-G, -E and -F genes

Author:
Antonio Arnaiz-Villena; Fabio Suarez-Trujillo; Ignacio Juarez; Carmen Rodríguez-Sainz; José Palacio-Gruber; Christian Vaquero-Yuste; Marta Molina-Alejandre; Eduardo Fernández-Cruz; José Manuel Martin-Villa
Source:
Cellular and molecular life sciences 2022 v.79 no.8 pp. 464
ISSN:
1420-682X
Subject:
major histocompatibility complex,   etc   ; HLA antigens; alleles; coevolution; complement; haplotypes; humans; immunomodulation; pathogenesis; statistics;     Show all 10 Subjects
Abstract:
... Classical HLA (Human Leukocyte Antigen) is the Major Histocompatibility Complex (MHC) in man. HLA genes and disease association has been studied at least since 1967 and no firm pathogenic mechanisms have been established yet. HLA-G immune modulation gene (and also -E and -F) are starting the same arduous way: statistics and allele association are the trending subjects with the same few results obt ...
DOI:
10.1007/s00018-022-04491-z

8. Swine unconventional T cells

Author:
Miaomiao Wu; Qianling Jiang; Ali Nazmi; Jie Yin; Guan Yang
Source:
Developmental and comparative immunology 2022 v.128 pp. 104330
ISSN:
0145-305X
Subject:
major histocompatibility complex,   etc   ; T-lymphocytes; animal models; humans; metabolites; mice; peptides; swine; vaccines;     Show all 9 Subjects
Abstract:
... Pigs are important domestic livestock and a comprehensive understanding of their immune system is critical to improve swine vaccine efficacy. Pig models represent an excellent animal model for immunological studies because of their anatomical and physiological similarities to humans. A significant portion of pig immunological studies focused on characterizing the conventional T cell (Tconv) immune ...
DOI:
10.1016/j.dci.2021.104330

9. Recombination and mutation shape variations in the major histocompatibility complex

Author:
Yuying Sun; Fang Yuan; Ling Wang; Dongfa Dai; Zhijian Zhang; Fei Liang; Nan Liu; Juan Long; Xiao Zhao; Yongzhi Xi
Source:
Journal of genetics and genomics 2022 pp. -
ISSN:
1673-8527
Subject:
major histocompatibility complex,   etc   ; Chinese people; genomics; haplotypes; linkage disequilibrium; loci; mutation; mutation rate;     Show all 8 Subjects
Abstract:
... The major histocompatibility complex (MHC) is closely associated with numerous diseases, but its high degree of polymorphism complicates the discovery of disease-associated variants. In principle, recombination and de novo mutations are two critical factors responsible for MHC polymorphisms. However, direct evidence for this hypothesis is lacking. Here, we report the generation of fine-scale MHC r ...
DOI:
10.1016/j.jgg.2022.03.006

10. TLR2 and TLR4 molecules and antigen‐presenting cell compositions in cecal tonsils of broiler chicks (Gallus gallus domesticus) in the first two weeks of the post‐hatch period

Author:
Ulker Eren; Sadiye Kum; Ahmet Nazligul; Ozay Gules; Ebru Aka; Mustafa Yildiz; Secil Zorlu
Source:
Anatomia, histologia, embryologia 2022 v.51 no.1 pp. 125-135
ISSN:
0340-2096
Subject:
major histocompatibility complex,   etc   ; antigen presentation; cecum; immunohistochemistry; innate immunity; lymph; silver; tonsils; vaccination;     Show all 9 Subjects
Abstract:
... Chickens do not have lymph nodes. Gut‐associated lymphoid tissue is the major immunological organization for the digestive system. Cecal tonsils are an important part of this organization. This study is a descriptive and experimental study that was conducted to determine the histological development of the cecal tonsils and the distribution of Toll‐like receptor (TLR) 2, TLR4 and antigen‐presentin ...
DOI:
10.1111/ahe.12773

11. MHC IIβ diversity of Oreochromis niloticus and its association with the susceptibility/resistance to Gyrodactylus cichlidarum (Monogenea) infection

Author:
Jinsong Chen; Yingying Zheng; Tingting Zhi; Christopher L. Brown; Tingbao Yang
Source:
Aquaculture reports 2022 v.25 pp. 101228
ISSN:
2352-5134
Subject:
major histocompatibility complex,   etc   ; Gyrodactylus; Oreochromis niloticus; alleles; amino acids; disease resistance; farmed fish; immunity;     Show all 8 Subjects
Abstract:
... Nile tilapia, Oreochromis niloticus, is among the most highly recommended species by the FAO for culture, and has become the second most abundantly farmed fish species in the world. In aquaculture systems, however, this species is vulnerable to various pathogens including Gyrodactylus cichlidarum (Monogenea). The major histocompatibility complex (MHC), a highly polymorphic gene superfamily, plays ...
DOI:
10.1016/j.aqrep.2022.101228

12. A computational algorithm to assess the physiochemical determinants of T cell receptor dissociation kinetics

Author:
Zachary A. Rollins; Jun Huang; Ilias Tagkopoulos; Roland Faller; Steven C. George
Source:
Computational and Structural Biotechnology Journal 2022 v.20 pp. 3473-3481
ISSN:
2001-0370
Subject:
major histocompatibility complex,   etc   ; T-lymphocytes; algorithms; biotechnology; dissociation; hydrogen; immunogenicity; immunotherapy; ligands; molecular dynamics;     Show all 10 Subjects
Abstract:
... The rational design of T Cell Receptors (TCRs) for immunotherapy has stagnated due to a limited understanding of the dynamic physiochemical features of the TCR that elicit an immunogenic response. The physiochemical features of the TCR-peptide major histocompatibility complex (pMHC) bond dictate bond lifetime which, in turn, correlates with immunogenicity. Here, we: i) characterize the force-depen ...
DOI:
10.1016/j.csbj.2022.06.048

13. Using digital RNA counting to establish flow cytometry diagnostic criteria for subtypes of CD34+ canine acute leukaemia

Author:
R. Adam Harris; Emily D. Rout; Janna A. Yoshimoto; Paul R. Avery; Anne C. Avery
Source:
Veterinary and comparative oncology 2022 v.20 no.3 pp. 710-719
ISSN:
1476-5810
Subject:
major histocompatibility complex,   etc   ; antigens; dogs; flow cytometry; gene expression regulation; immunophenotyping; lymph; myeloid leukemia;     Show all 8 Subjects
Abstract:
... Canine acute leukaemia is a heterogeneous neoplasm with multiple phenotypes. Criteria to subtype acute leukaemia by flow cytometry have not been validated. The goal of this study was to develop a panel of antibodies and objective antigen expression criteria for the assignment of lymphoid or myeloid lineage by flow cytometry. We isolated mRNA from the blood of 45 CD34+ acute leukaemia cases and mea ...
DOI:
10.1111/vco.12825

14. A robust sequencing assay of a thousand amplicons for the high‐throughput population monitoring of Alpine ibex immunogenetics

Author:
Camille Kessler; Alice Brambilla; Dominique Waldvogel; Glauco Camenisch; Iris Biebach; Deborah M. Leigh; Christine Grossen; Daniel Croll
Source:
Molecular ecology resources 2022 v.22 no.1 pp. 66-85
ISSN:
1755-098X
Subject:
major histocompatibility complex,   etc   ; Capra ibex; extinction; genetic variation; genotyping; mammals; population structure; reproductive success;     Show all 8 Subjects
Abstract:
... Polymorphism for immune functions can explain significant variation in health and reproductive success within species. Drastic loss in genetic diversity at such loci constitutes an extinction risk and should be monitored in species of conservation concern. However, effective implementations of genome‐wide immune polymorphism sets into high‐throughput genotyping assays are scarce. Here, we report t ...
DOI:
10.1111/1755-0998.13452

15. Getting in the groove: The selection of MHC-I antigen repertoires by molecular chaperones is governed by a network of protein dynamics

Author:
Nikolaos Sgourakis
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
major histocompatibility complex,   etc   ; antigens; aqueous solutions; cell membranes; disulfide bonds; humans; mice; molecular dynamics; peptides;     Show all 9 Subjects
Abstract:
... Conformational dynamics have been implicated in regulating key aspects of class I major histocompatibility complex (MHC-I) function, including association with peptide antigens, and recognition of peptide-editing chaperones in an MHC-I allele-specific manner. Molecular dynamics simulations have provided insights into motions up to the microseconds timescale, however biophysical parameters characte ...
DOI:
10.1016/j.molimm.2022.05.078

16. CDR3 binding chemistry controls TCR V-domain rotational probability and germline CDR2 scanning of polymorphic MHC

Author:
Joseph S. Murray
Source:
Molecular immunology 2022 v.144 pp. 138-151
ISSN:
0161-5890
Subject:
major histocompatibility complex,   etc   ; T-lymphocytes; antigens; chemistry; genotype; geometry; germ cells; hydrogen; ligands; peptides; probability; therapeutics;     Show all 12 Subjects
Abstract:
... The mechanism which adapts the T-cell antigen receptor (TCR) within a given major histocompatibility complex (MHC/HLA) genotype is essential for protection against pathogens. Historically attributed to relative affinity, genetically vast TCRs are surprisingly focused towards a micromolar affinity for their respective peptide (p) plus MHC (pMHC) ligands. Thus, the somatic diversity of the TCR with ...
DOI:
10.1016/j.molimm.2021.11.015

17. Expression of the Nonclassical MHC Class I, Saha-UD in the Transmissible Cancer Devil Facial Tumour Disease (DFTD)

Author:
Kathryn Hussey; Alison Caldwell; Alexandre Kreiss; Karsten Skjødt; Annalisa Gastaldello; Ruth Pye; Rodrigo Hamede; Gregory M. Woods; Hannah V. Siddle
Source:
Pathogens 2022 v.11 no.3 pp. -
ISSN:
2076-0817
Subject:
major histocompatibility complex,   etc   ; Sarcophilus harrisii; Western blotting; epigenetics; immune response; immunohistochemistry; immunosuppression; ligands; monoclonal antibodies; neoplasms;     Show all 10 Subjects
Abstract:
... Devil facial tumour disease (DFTD) is a transmissible cancer that has circulated in the Tasmanian devil population for >25 years. Like other contagious cancers in dogs and devils, the way DFTD escapes the immune response of its host is a central question to understanding this disease. DFTD has a low major histocompatibility complex class I (MHC-I) expression due to epigenetic modifications, preven ...
DOI:
10.3390/pathogens11030351

18. MHC class I‐α population differentiation in a commercial fish, the European sea bass (Dicentrarchus labrax)

Author:
Frances C. Ratcliffe; Carlos Garcia de Leaniz; Sofia Consuegra
Source:
Animal genetics 2022 v.53 no.3 pp. 340-351
ISSN:
0268-9146
Subject:
major histocompatibility complex,   etc   ; Bayesian theory; Dicentrarchus labrax; adaptive immunity; allelic variation; animal genetics; aquaculture; population structure;     Show all 8 Subjects
Abstract:
... Identifying population structuring in highly fecund marine species with high dispersal rates is challenging, but critical for conservation and stock delimitation for fisheries management. European sea bass (Dicentrarchus labrax) is a commercial species of fisheries and aquaculture relevance whose stocks are declining in the North Atlantic, despite management measures to protect them and identifyin ...
DOI:
10.1111/age.13184

19. The atomistic face of the human MHC-I peptide-loading complex

Author:
Olivier Fisette; Lars Schäfer
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
major histocompatibility complex,   etc   ; adaptive immunity; antigens; catalysts; cytotoxicity; humans; models; molecular dynamics; mutagenesis; peptides; plasticity; solvents;     Show all 12 Subjects
Abstract:
... Antigens exposed at the cell surface by major histocompatibility complex class I (MHC-I) proteins enable self/non-self recognition by cytotoxic T cells, protecting the organism against viral infections and cancer-causing mutations. To perform their role, MHC-I must first be loaded with an antigenic peptide in the peptide-loading complex (PLC), a large multi-protein assembly whose atomic-level stru ...
DOI:
10.1016/j.molimm.2022.05.036

20. An opinion on the debatable function of brain resident immune protein, T-cell receptor beta subunit in the central nervous system

Author:
Pragya Komal; S.K.V. Manjari; Raad Nashmi
Source:
IBRO neuroscience reports 2022 v.13 pp. 235-242
ISSN:
2667-2421
Subject:
major histocompatibility complex,   etc   ; T-lymphocytes; Toll-like receptors; biomarkers; brain; immunoglobulins; neurogenesis; neurons; neuroplasticity; synaptic transmission;     Show all 10 Subjects
Abstract:
... In recent years scientific research has established that the nervous and immune systems have shared molecular signaling components. Proteins native to immune cells, which are also found in the brain, have neuronal functions in the nervous system where they affect synaptic plasticity, axonal regeneration, neurogenesis, and neurotransmission. Certain native immune molecules like major histocompatibi ...
DOI:
10.1016/j.ibneur.2022.09.003