PubAg

Main content area

You searched for: Subject "mammals" Remove constraint Subject: "mammals"
Start Over

Search

16,930  Search Results

« Previous | 1 - 20 of 16,930 |
Number of results to display per page

Search Results

1. RNA nanostructures and scaffolds for biotechnology applications

Author:
Ohno, Hirohisa; Akamine, Sae; Saito, Hirohide
Source:
Current opinion in biotechnology 2019 v.58 pp. 53-61
ISSN:
0958-1669
Subject:
mammals,   etc   ; RNA; bioengineering; biotechnology; medicine; nanomaterials; proteins;     Show all 7 Subjects
Abstract:
... RNA plays important roles in the regulation of gene expressions and other cellular functions. It functions as both as an informational carrier and a nanomachine due to its complementary base-pairing ability and complexed three-dimensional structure. Several nanostructures have been designed and constructed by exploiting these natural RNA properties. In this review, we will introduce the design pri ...
DOI:
10.1016/j.copbio.2018.11.006

2. Molecular engineering strategies and methods for the expression and purification of IgG1-based bispecific bivalent antibodies

Author:
Dimasi, N.; Fleming, R.; Wu, H.; Gao, C.
Source:
Methods 2019 v.154 pp. 77-86
ISSN:
1046-2023
Subject:
mammals,   etc   ; antibodies; engineering; inflammation; neoplasms; therapeutics;     Show all 6 Subjects
Abstract:
... In recent years, bispecific antibodies (BisAbs) have emerged as novel pharmaceutical candidates owing to their ability to engage two disease mediators simultaneously, thus providing a possible alternative therapeutic approach in complex diseases such as cancer and inflammation. Here we provide an overview of the molecular design, recombinant expression in mammalian cells and purification of BisAbs ...
DOI:
10.1016/j.ymeth.2018.08.004

3. Correction to: getting fat or getting help? how female mammals cope with energetic constraints on reproduction

Author:
Heldstab, Sandra A.; van Schaik, Carel P.; Isler, Karin
Source:
Frontiers in zoology 2018 v.15 no.1 pp. 3
ISSN:
1742-9994
Subject:
mammals,   etc   ; females; reproduction;     Show all 3 Subjects
Abstract:
... CORRECTION: Unfortunately, upon publication of this article [1] it was noticed there was an error within the Discussion section. During proofing a request to edit the following paragraph was missed: ...
DOI:
10.1186/s12983-017-0236-7

4. With a little help from her friends (and family) part II: Non-maternal caregiving behavior and physiology in mammals

Author:
Rosenbaum, Stacy; Gettler, Lee T.
Source:
Physiology & behavior 2018 v.193 pp. 12-24
ISSN:
0031-9384
Subject:
mammals,   etc   ; physiology; surveys;     Show all 3 Subjects
Abstract:
... The diversity of competing frameworks for explaining the evolution of non-maternal care in mammals (Part I, this issue) reflects the vast range of behaviors and associated outcomes these theories attempt to subsume. Caretaking comprises a wide variety of behavioral domains, and is mediated by an equally large range of physiological systems. In Part II, we provide an overview of how non-maternal ca ...
DOI:
10.1016/j.physbeh.2017.12.027

5. Mammals and meaningful taxonomic units: the debate about species concepts and conservation

Author:
Zachos, Frank E.
Source:
Mammal review 2018 v.48 no.3 pp. 153-159
ISSN:
0305-1838
Subject:
mammals,   etc   ; phylogeny; taxonomy;     Show all 3 Subjects
Abstract:
... Mammalian taxonomy based on the diagnosability version of the Phylogenetic Species Concept has recently been declared the only sound approach to mammalian classification. In this article, based on the underlying evolutionary ontology of species taxa, I explain the fallacy of these arguments and hold that in a ‘grey area’ after lineage sundering, completely objective species delimitation is impossi ...
DOI:
10.1111/mam.12121

6. 5C-ID: Increased resolution Chromosome-Conformation-Capture-Carbon-Copy with in situ 3C and double alternating primer design

Author:
Kim, Ji Hun; Titus, Katelyn R.; Gong, Wanfeng; Beagan, Jonathan A.; Cao, Zhendong; Phillips-Cremins, Jennifer E.
Source:
Methods 2018 v.142 pp. 39-46
ISSN:
1046-2023
Subject:
mammals,   etc   ; chromatin; genome; topology;     Show all 4 Subjects
Abstract:
... Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs), subTADs, and looping interactions. Currently, there is a great need to evaluate the link between chromatin topology and genome function across many biological conditions and genetic perturbations. Hi-C can generate genome-wide maps of looping interactions but is intractable for high-throughput co ...
DOI:
10.1016/j.ymeth.2018.05.005

7. Prostaglandins in teleost ovulation: A review of the roles with a view to comparison with prostaglandins in mammalian ovulation

Author:
Takahashi, Takayuki; Hagiwara, Akane; Ogiwara, Katsueki
Source:
Molecular and cellular endocrinology 2018 v.461 pp. 236-247
ISSN:
0303-7207
Subject:
mammals,   etc   ; oocytes; ovulation; prostaglandins;     Show all 4 Subjects
Abstract:
... Prostaglandins are well known to be central regulators of vertebrate ovulation. Studies addressing the role of prostaglandins in mammalian ovulation have established that they are involved in the processes of oocyte maturation and cumulus oocyte complex expansion. In contrast, despite the first indication of the role of prostaglandins in teleost ovulation appearing 40 years ago, the mechanistic ba ...
DOI:
10.1016/j.mce.2017.09.019

8. Reprogramming the brain with synthetic neurobiology

Author:
Gardner, Elizabeth; Ellington, Andrew
Source:
Current opinion in biotechnology 2019 v.58 pp. 37-44
ISSN:
0958-1669
Subject:
mammals,   etc   ; brain; electrophysiology; genetic techniques and protocols; microscopy; neurodevelopment; neurophysiology;     Show all 7 Subjects
Abstract:
... The mammalian brain is among the most complex organs known in biology. Historically, neuroscience techniques have consisted primarily of low-throughput microscopy and electrophysiological approaches. While these methods will continue to serve the community, the emerging field of synthetic neurobiology may be better equipped to scale with systems neuroscience. By using genetic techniques to achieve ...
DOI:
10.1016/j.copbio.2018.10.013

9. Altricial-precocial spectra in animal kingdom

Author:
Augustine, Starrlight; Lika, Konstadia; Kooijman, Sebastiaan A.L.M.
Source:
Journal of sea research 2019 v.143 pp. 27-34
ISSN:
1385-1101
Subject:
mammals,   etc   ; Chondrichthyes; Weibull statistics; birds; energy; insects; metabolism; puberty;     Show all 8 Subjects
Abstract:
... Traditionally, the terms altricial and precocial are used to described the state at birth of birds and mammals. We suggest an explanation for why birds evolved from precocial to altricial and mammals from altricial to precocial. However, the concept is not confined to these groups alone and is an important pattern underlying all animal metabolism. Being able to quantify it, helps position species ...
DOI:
10.1016/j.seares.2018.03.006

10. Correction to: Runs of homozygosity have utility in mammalian conservation and evolutionary studies

Author:
Brüniche-Olsen, Anna; Kellner, Kenneth F.; Anderson, Chase J.; DeWoody, J. Andrew
Source:
Conservation genetics 2018 v.19 no.6 pp. 1309
ISSN:
1566-0621
Subject:
mammals,   etc   ; genetic variation; homozygosity; inbreeding;     Show all 4 Subjects
Abstract:
... The fourth author’s name was incorrect in the original publication and correct author name is given in this Correction. ...
DOI:
10.1007/s10592-018-1104-5

11. Comparing disturbance and generalism in birds and mammals: A hump-shaped pattern

Author:
Battisti, Corrado; Fanelli, Giuliano
Source:
Basic and applied ecology 2018 v.30 pp. 96-99
ISSN:
1439-1791
Subject:
mammals,   etc   ; anthropogenic activities; birds; habitats;     Show all 4 Subjects
Abstract:
... Using indices as proxies, we observed that comparing a large number of common birds and mammals, the level of generalism peaks in species inhabiting habitats at intermediate disturbance levels. This pattern might be universal, at least in these homeothermic vertebrates. Birds show nonetheless some differences in pattern from mammals, where specialization at intermediate levels of disturbance is no ...
DOI:
10.1016/j.baae.2018.04.004

12. SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X

Author:
Wang, Chen-Yu; Jégu, Teddy; Chu, Hsueh-Ping; Oh, Hyun Jung; Lee, Jeannie T.
Source:
Cell 2018 v.174 no.2 pp. 406-421.e25
ISSN:
0092-8674
Subject:
mammals,   etc   ; X chromosome; heterochromatin; models;     Show all 4 Subjects
Abstract:
... Mammalian chromosomes are partitioned into A/B compartments and topologically associated domains (TADs). The inactive X (Xi) chromosome, however, adopts a distinct conformation without evident compartments or TADs. Here, through exploration of an architectural protein, structural-maintenance-of-chromosomes hinge domain containing 1 (SMCHD1), we probe how the Xi is reconfigured during X chromosome ...
DOI:
10.1016/j.cell.2018.05.007

13. Species delimitation in mammals: A response to Gippoliti

Author:
Zachos, Frank E.
Source:
Mammalian biology = 2018
ISSN:
1616-5047
Subject:
mammals,   etc   ; evolution; taxonomy; wildlife management;     Show all 4 Subjects
Abstract:
... In a comment published in this issue, Spartaco Gippoliti (2019) presents a critique of a recent perspective paper of mine (Zachos, 2018a). Specifically, he accuses me of diminishing taxonomy and of denying it its proper role in conservation biology. Here I respond to these criticisms and argue that taxonomy is necessary but not sufficient for delineating appropriate units for conservation due to i ...
DOI:
10.1016/j.mambio.2018.05.008

14. Evaluation of orchiectomy and ovariectomy surgical techniques in degus (octodon degus)

Author:
Malbrue, Raphael A.; Arsuaga-Zorrilla, Carmen B.; Bidot, Willie; Molitor, Laure E.; Mendoza, Kriscelle A.; Barnes, Shateenah K.; Alexander, Derecka J.; Bova, Jonathan F.; Evans, Dawn E.
Source:
Journal of exotic pet medicine 2019 v.30 pp. 22-28
ISSN:
1557-5063
Subject:
small mammals,   etc   ; Octodon degus; adults; anesthesia; castration; control methods; females; males; ovariectomy; pain; saliva; secretion;     Show all 12 Subjects
Abstract:
... In this study, 2 previously described surgical techniques for performing an orchiectomy in the adult male degu (Octodon degus) were evaluated: (1) prescrotal open technique and (2) scrotal open technique. Additionally, an ovariectomy procedure was assessed in female degus using the bilateral (dorsolateral) technique similar to that performed in related species. Twenty two animals (n = 14 males; 8 ...
DOI:
10.1053/j.jepm.2018.08.003

15. Molecular dynamics and structural models of the cyanobacterial NDH-1 complex

Author:
Saura, Patricia; Kaila, Ville R.I.
Source:
Biochimica et biophysica acta 2019 v.1860 no.3 pp. 201-208
ISSN:
0005-2728
Subject:
mammals,   etc   ; X-radiation; energy; molecular dynamics; molecular models; photosynthesis; proton pump;     Show all 7 Subjects
Abstract:
... NDH-1 is a gigantic redox-driven proton pump linked with respiration and cyclic electron flow in cyanobacterial cells. Based on experimentally resolved X-ray and cryo-EM structures of the respiratory complex I, we derive here molecular models of two isoforms of the cyanobacterial NDH-1 complex involved in redox-driven proton pumping (NDH-1L) and CO2-fixation (NDH-1MS). Our models show distinct str ...
DOI:
10.1016/j.bbabio.2018.11.010

16. Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1)

Author:
Ježek, Petr; Jabůrek, Martin; Porter, Richard K.
Source:
Biochimica et biophysica acta 2019 v.1860 no.3 pp. 259-269
ISSN:
0005-2728
Subject:
mammals,   etc   ; anions; biogenesis; brown adipose tissue; fatty acids; heat production; mitochondria; models; post-translational modification;     Show all 9 Subjects
Abstract:
... Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering thermogenesis. Mitochondrial uncoupling protein 1 (UCP1), specific for these tissues, is the key factor for heat production. Recent molecular aspects of UCP1 structure provide support for the fatty acid cycling model of coupling, i.e. when UCP1 expels fa ...
DOI:
10.1016/j.bbabio.2018.11.007

17. Evaluation of kinetic data: What the numbers tell us about PRMTs

Author:
Frankel, Adam; Brown, Jennifer I.
Source:
Biochimica et biophysica acta 2019 v.1867 no.3 pp. 306-316
ISSN:
1570-9639
Subject:
mammals,   etc   ; S-adenosylmethionine; arginine; catalytic activity; databases; enzyme activity; enzyme substrates; lysine; methylation; methyltransferases;     Show all 10 Subjects
Abstract:
... Protein arginine N-methyltransferase (PRMT) kinetic parameters have been catalogued over the past fifteen years for eight of the nine mammalian enzyme family members. Like the majority of methyltransferases, these enzymes employ the highly ubiquitous cofactor S-adenosyl-l-methionine as a co-substrate to methylate arginine residues in peptidic substrates with an approximately 4-μM median KM. The me ...
DOI:
10.1016/j.bbapap.2018.10.010

18. Emission profiles and formation pathways of 2,3,7,8-substituted and non-2,3,7,8-substituted polychlorinated dibenzo-p-dioxins and dibenzofurans in secondary copper smelters

Author:
Li, Haifeng; Liu, Wenbin; Tang, Chen; Lei, Rongrong; Zhu, Wen
Source:
The Science of the total environment 2019 v.649 pp. 473-481
ISSN:
0048-9697
Subject:
mammals,   etc   ; chlorination; copper; dibenzofuran; fly ash; gases; metabolism; oxidation; polychlorinated dibenzodioxins; polychlorinated dibenzofurans; toxicity; toxicology;     Show all 12 Subjects
Abstract:
... Secondary copper smelting production is one of the largest polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) emission sources in the world. However, the formations and emissions of non-2,3,7,8-PCDD/Fs have rarely been studied. Toxicology and metabolism studies have proved that non-2,3,7,8-PCDD/Fs may also be toxic to mammals. To better explore the pathways and mechanisms involved in tr ...
DOI:
10.1016/j.scitotenv.2018.08.279

19. Generation of Fabs-in-tandem immunoglobulin molecules for dual-specific targeting

Author:
Gong, Shiyong; Wu, Chengbin
Source:
Methods 2019 v.154 pp. 87-92
ISSN:
1046-2023
Subject:
mammals,   etc   ; immunoglobulins; manufacturing; mechanism of action; molecular biology; monoclonal antibodies; mutation; pharmaceutical industry;     Show all 8 Subjects
Abstract:
... Bispecific antibody (BsAb) has become an important trend in developing next generation biologics therapies. By simultaneously engaging two molecular targets, BsAbs show distinctive mechanism of actions that could lead to clinical benefits unattainable by conventional monoclonal antibodies (mAbs). Successful launch provided clinical validation and encourage more BsAb development in the pipeline of ...
DOI:
10.1016/j.ymeth.2018.07.014

20. Effect of waves on the leading-edge undulated tidal turbines

Author:
Shi, Weichao; Atlar, Mehmet; Norman, Rosemary; Day, Sandy; Aktas, Batuhan
Source:
Renewable energy 2019 v.131 pp. 435-447
ISSN:
0960-1481
Subject:
mammals,   etc   ; Megaptera novaeangliae; biomimetics; blades; hydrodynamics; models; renewable energy sources; tides; turbines;     Show all 9 Subjects
Abstract:
... This paper presents an investigation on the efficiency performance of the leading-edge undulated tidal turbine blades under the effect of waves. This biomimetic blade application is inspired by humpback whale flippers which provide these mammals with an exceptional manoeuvring ability that is mainly accredited to the beneficial of their leading-edge tubercles. The paper first presents the design, ...
DOI:
10.1016/j.renene.2018.07.072