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1. Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland

Author:
Cai, Cheguo; Geng, Ajun; Wang, Mengran; Yang, Li; Yu, Qing Cissy; Zeng, Yi Arial
Source:
Developmental biology 2020 v.458 no.1 pp. 43-51
ISSN:
0012-1606
Subject:
mammary glands,   etc   ; epithelial cells; estrogen receptors; growth factors; hormonal regulation; steroid hormones;     Show all 6 Subjects
Abstract:
... The steroid hormones are instrumental for the growth of mammary epithelial cells. Our previous study indicates that hormones regulate the expression of Rspondin-1 (Rspo1). Yet, the regulatory mechanism remains unknown. In the current study, we identify Amphiregulin (Areg) as a novel upstream regulator of Rspo1 expression mediating the hormonal influence. In response to hormonal signaling, Areg ema ...
DOI:
10.1016/j.ydbio.2019.10.006

2. Triple-negative mammary carcinoma in two male dogs

Author:
Machado, Marília C. A.; Ocarino, Natalia M.; Serakides, Rogéria; Moroz, Ludmila R.; Sementilli, Angelo; Damasceno, Karine A.; Cruz, Claudia H.; Estrela-Lima, Alessandra
Source:
Journal of veterinary diagnostic investigation 2020 v.32 no.1 pp. 94-98
ISSN:
1943-4936
Subject:
mammary glands,   etc   ; breast neoplasms; carcinoma; dogs; erbB-2 receptor; immunohistochemistry; males; sex hormone receptors;     Show all 8 Subjects
Abstract:
... Triple-negative tumors are characterized immunohistochemically by the absence of positivity to sex hormone receptors and to human epidermal growth factor receptor 2. Additionally, they are differentiated into basal-like and non-basal (or null) subtypes, based on the presence of basal cytokeratin expression (CK5/6, 14, and17). Triple-negative subtypes are yet to be characterized in male dogs, to ou ...
DOI:
10.1177/1040638719898686
PubMed:
31924140
PubMed Central:
PMC7003223

3. Staphylococcus aureus metal acquisition in the mastitic mammary gland

Author:
Carlson, Shalee K.; Erickson, David L.; Wilson, Eric
Source:
Microbial pathogenesis 2020 v.144 pp. 104179
ISSN:
0882-4010
Subject:
mammary glands,   etc   ; Staphylococcus aureus; cobalt; copper; dairy industry; financial economics; iron; lactation; manganese; mastitis; nickel; pathogenesis; therapeutics; virulence; zinc;     Show all 15 Subjects
Abstract:
... Mastitis, resulting from mammary gland infection, is a common and painful disease associated with lactation. In addition to the impact on human and animal health, mastitis causes substantial economic losses in the dairy industry. Staphylococcus aureus is a frequent cause of mastitis worldwide. Despite significant progress in understanding S. aureus pathogenesis in general, much remains to be learn ...
DOI:
10.1016/j.micpath.2020.104179

4. α-catenin, β-catenin and P-120-catenin immunoexpression in canine mammary tissues and their relationship with E-cadherin

Author:
da Rocha, Aline Alvarenga; Carvalheira, Júlio; Gärtner, Fátima
Source:
Research in veterinary science 2020 v.130 pp. 197-202
ISSN:
0034-5288
Subject:
mammary glands,   etc   ; alpha catenin; animal tissues; beta catenin; cadherins; cell adhesion; dogs; epithelial cells; immunohistochemistry; mammary neoplasms (animal); metastasis;     Show all 11 Subjects
Abstract:
... Mammary tumors represent the second most common neoplasia in the canine species, where more than 50% of the cases are classified as malignant. The histological classification is used as a prognostic tool. Cadherins and catenins are responsible for cell adhesion and are intrinsic connected with the process of metastasis. E-cadherin expression in canine mammary tissues have been extensively studied. ...
DOI:
10.1016/j.rvsc.2020.03.002

5. The canine RAD51 mutation leads to the attenuation of interaction with PALB2

Author:
Uemura, Mitsuki; Ochiai, Kazuhiko; Morimatsu, Masami; Michishita, Masaki; Onozawa, Eri; Azakami, Daigo; Uno, Yumiko; Yoshikawa, Yasunaga; Sasaki, Takanori; Watanabe, Masami; Omi, Toshinori
Source:
Veterinary and comparative oncology 2020 v.18 no.2 pp. 247-255
ISSN:
1476-5810
Subject:
mammary glands,   etc   ; DNA damage; dogs; eukaryotic cells; homologous recombination; humans; mutants; mutation; neoplasms; prokaryotic cells; tissues; tumor suppressor proteins;     Show all 12 Subjects
Abstract:
... RAD51 forms a complex with BRCA2 and plays a central role in the DNA damage response pathway that is associated with homologous recombination. The structures of RAD51 and its homologues are highly conserved from prokaryotes to higher eukaryotes. Although a large number of BRCA2 mutations have been reported, there are only a few reports on the mutations of RAD51, which have been shown in humans and ...
DOI:
10.1111/vco.12542

6. Intramammary honey preparation for treatment of subclinical bovine mastitis: a preliminary study

Author:
Benhanifia, Mokhtar; Ayad, Abdelhanine; Mohamed, Wessam
Source:
Organic agriculture 2020 v.10 no.1 pp. 1-8
ISSN:
1879-4238
Subject:
mammary glands,   etc   ; Pseudomonas aeruginosa; Staphylococcus aureus; bovine mastitis; cows; honey; lactation; medicine; microorganisms; milk; organic production; pathogens; therapeutics;     Show all 13 Subjects
Abstract:
... Honey has been used in medicine against bacterial infections for thousands of years. The objective of this study was to evaluate the efficacy of intramammary honey administered during lactating period to eliminate Staphylococcus aureus and Pseudomonas aeruginosa infection. Three infected cows were investigated. Five milliliters of multifloral undiluted honey was administered aseptically in quarter ...
DOI:
10.1007/s13165-019-00244-8

7. Ovine mammary morphology and associations with milk production, milkability and animal selection

Author:
Pourlis, Aris
Source:
Small ruminant research 2020 v.184 pp. 106009
ISSN:
0921-4488
Subject:
mammary glands,   etc   ; dairy sheep; digital images; genetic improvement; image analysis; milk production; quantitative trait loci; sheep; udders; ultrasonography;     Show all 10 Subjects
Abstract:
... In current dairy sheep management, there is a widespread trend to improve the morphology of the udder for machine- and hand-milking ability. The purpose of this review is to present the literature regarding udder morphological traits related to milk production of sheep. The ovine udder consists of two mammary glands. Various techniques have been employed to appraise the mammary morphology and anat ...
DOI:
10.1016/j.smallrumres.2019.10.010

8. Glyphosate-based herbicide induces hyperplastic ducts in the mammary gland of aging Wistar rats

Author:
Zanardi, María V.; Schimpf, Marlise Guerrero; Gastiazoro, María P.; Milesi, María M.; Muñoz-de-Toro, Mónica; Varayoud, Jorgelina; Durando, Milena
Source:
Molecular and cellular endocrinology 2020 v.501 pp. 110658
ISSN:
0303-7207
Subject:
mammary glands,   etc   ; adverse effects; blood serum; estradiol; females; glyphosate; long term effects; progesterone; pups; steroid hormone receptors; tissues;     Show all 11 Subjects
Abstract:
... Glyphosate-based herbicide (GBH) exposure is known to have adverse effects on endocrine-related tissues. Here, we aimed to determine whether early postnatal exposure to a GBH induces long-term effects on the rat mammary gland. Thus, female Wistar pups were injected with saline solution (Control) or GBH (2 mg glyphosate/kg/day) on postnatal days (PND) 1, 3, 5 and 7. At 20 months of age, mammary gla ...
DOI:
10.1016/j.mce.2019.110658

9. Alveolar progenitor cells in the mammary gland are dependent on the β4 integrin

Author:
Walker, Melanie R.; Amante, John J.; Li, Jiarong; Liu, Haibo; Zhu, Lihua Julie; Feltri, M. Laura; Goel, Hira Lal; Mercurio, Arthur M.
Source:
Developmental biology 2020 v.457 no.1 pp. 13-19
ISSN:
0012-1606
Subject:
mammary glands,   etc   ; breast neoplasms; cell lines; epithelial cells; integrins; mice; milk production; pregnancy; sequence analysis; stem cells; whey;     Show all 11 Subjects
Abstract:
... Understanding how progenitor cell function is regulated in the mammary gland is an important developmental problem that has significant implications for breast cancer. Although it had been assumed that the expression the α6β4 integrin (β4) is restricted to the basal lineage, we report that alveolar progenitor cells in the mouse mammary gland also express this integrin based on analysis of single c ...
DOI:
10.1016/j.ydbio.2019.10.001

10. Effect of the key histone modifications on the expression of genes related to breast cancer

Author:
Jin, Wen; Li, Qian-Zhong; Liu, Yuan; Zuo, Yong-Chun
Source:
Genomics 2020 v.112 no.1 pp. 853-858
ISSN:
0888-7543
Subject:
mammary glands,   etc   ; breast neoplasms; breasts; carcinogenesis; epithelial cells; gene expression; gene expression regulation; genes; histones; humans; neoplasm cells; transcription factors;     Show all 12 Subjects
Abstract:
... Abnormal histone modifications (HMs) and transcription factors (TFs) can alter the expression of cancer-related genes to promote tumorigenesis. We studied the variations of 11 HMs and 2 TFs in human breast cancer cells (MCF-7) compared to human normal mammary epithelial cells (HMEC), and the effects of HMs/TFs in various regions of the genome on the expression changes of breast cancer-related gene ...
DOI:
10.1016/j.ygeno.2019.05.026

11. Use of commercial somatic cell counters to quantify somatic cells in non-lactating bovine mammary gland secretions

Author:
Enger, B.D.; Nickerson, S.C.; Akers, R.M.; Moraes, L.E.; Crutchfield, C.E.
Source:
Preventive veterinary medicine 2020 v.174 pp. 104775
ISSN:
0167-5877
Subject:
mammary glands,   etc   ; automation; bovine mastitis; counters; dairy cows; heifers; lactating females; lactation; milk; secretion; somatic cell count; somatic cells;     Show all 12 Subjects
Abstract:
... Measurement of the somatic cell count (SCC) in milk is commonly used to detect mastitis in lactating dairy cows. Many techniques and tools have been developed and adapted to quantify milk SCC, but few tools have been evaluated in their ability to enumerate somatic cells in non-lactating bovine mammary secretions. This limits the tools available for detecting mastitis in non-lactating animals. The ...
DOI:
10.1016/j.prevetmed.2019.104775

12. Mixed tumors of the canine mammary glands: Evaluation of prognostic factors, treatment, and overall survival

Author:
Nunes, Fernanda Camargo; Damasceno, Karine Araújo; de Campos, Cecília Bonolo; Bertagnolli, Angélica Cavalheiro; Lavalle, Gleidice Eunice; Cassali, Geovanni Dantas
Source:
Veterinary and Animal Science 2019 v.7 pp. 100039
ISSN:
2451-943X
Subject:
mammary glands,   etc   ; bitches; carcinosarcoma; mammary neoplasms (animal); metastasis; relapse; surgery;     Show all 7 Subjects
Abstract:
... Mixed tumors are the most frequent mammary gland neoplasms in bitches; however, studies that thoroughly describe their clinicopathological data, treatment approaches, and the survival of bitches with mixed tumors are scarce. This study evaluated the epidemiological and clinicopathological data, prognostic factors, and therapeutic approaches for bitches with mixed tumors. In all, 162 benign mixed t ...
DOI:
10.1016/j.vas.2018.09.003

13. 3D culture models for studying branching morphogenesis in the mammary gland and mammalian lung

Author:
Nerger, Bryan A.; Nelson, Celeste M.
Source:
Biomaterials 2019 v.198 pp. 135-145
ISSN:
0142-9612
Subject:
mammary glands,   etc   ; biochemical mechanisms; engineering; lungs; mammals; models; morphogenesis;     Show all 7 Subjects
Abstract:
... The intricate architecture of branched tissues and organs has fascinated scientists and engineers for centuries. Yet―despite their ubiquity―the biophysical and biochemical mechanisms by which tissues and organs undergo branching morphogenesis remain unclear. With the advent of three-dimensional (3D) culture models, an increasingly powerful and diverse set of tools are available for investigating t ...
DOI:
10.1016/j.biomaterials.2018.08.043
PubMed:
30174198
PubMed Central:
PMC6387650

14. IGF1R constitutive activation expands luminal progenitors and influences lineage differentiation during breast tumorigenesis

Author:
Farabaugh, Susan M.; Litzenburger, Beate C.; Elangovan, Ashuvinee; Pecar, Geoffrey; Walheim, Lauren; Atkinson, Jennifer M.; Lee, Adrian V.
Source:
Developmental biology 2020 v.463 no.1 pp. 77-87
ISSN:
0012-1606
Subject:
mammary glands,   etc   ; breast neoplasms; breasts; carcinogenesis; cell differentiation; epithelial cells; genetically modified organisms; mammary development; mammary neoplasms (animal); models; somatomedins; therapeutics; transcription factor NF-kappa B;     Show all 13 Subjects
Abstract:
... Breast tumors display tremendous heterogeneity in part due to varying molecular alterations, divergent cells of origin, and differentiation. Understanding where and how this heterogeneity develops is likely important for effective breast cancer eradication. Insulin-like growth factor (IGF) signaling is critical for normal mammary gland development and function, and has an established role in tumor ...
DOI:
10.1016/j.ydbio.2020.04.007

15. A Field Study of Serum, Colostrum, Milk Iodine, and Thyroid Hormone Concentrations in Postpartum Draft Mares and Foals

Author:
Cymbaluk, N.F.; Lopez-Rodriguez, Maria F.; Cymbaluk, Nadia F.; Epp, Tasha; Laarveld, Bernard; Thrasher, Mikhaela; Card, Claire E.
Source:
Journal of equine veterinary science 2020 v.90 pp. 103018
ISSN:
0737-0806
Subject:
mammary glands,   etc   ; animal tissues; blood sampling; blood serum; colostrum; epithelial cells; fetal development; foaling; foals; iodine; mares; milk; postpartum period; pregnancy; triiodothyronine;     Show all 15 Subjects
Abstract:
... Iodine, thyroxine (T4) and triiodothyronine (T3) are required for normal fetal growth, maturation, and neonatal survival. There is a lack of robust information on iodine levels found in colostrum, milk, and serum of mares and foals after a healthy pregnancy. Our objective was to characterize colostrum, milk, and serum iodine levels in healthy postpartum mares and foals (n = 10) and explore relatio ...
DOI:
10.1016/j.jevs.2020.103018

16. Biphasic Feline Mammary Carcinomas Including Carcinoma and Malignant Myoepithelioma

Author:
Sammarco, Alessandro; Finesso, Giovanni; Zanetti, Rossella; Ferro, Silvia; Rasotto, Roberta; Caliari, Diego; Goldschmidt, Michael H.; Orvieto, Enrico; Castagnaro, Massimo; Cavicchioli, Laura; Zappulli, Valentina
Source:
Veterinary pathology 2020 v.57 no.3 pp. 377-387
ISSN:
1544-2217
Subject:
mammary glands,   etc   ; actin; aggression; animal pathology; carcinosarcoma; cats; dogs; epithelium; estrogen receptors; females; humans; immunohistochemistry; mammary neoplasms (animal); muscles; phenotype; progesterone receptors; vimentin;     Show all 17 Subjects
Abstract:
... Feline mammary tumors are usually malignant and aggressive carcinomas. Most cases are simple monophasic carcinomas (1 epithelial population), and additional phenotyping is usually not needed. In this study, we describe 10 malignant mammary tumors from 9 female cats that had unusual histomorphology: they appeared biphasic, with 2 distinct cell populations. Initially, they were morphologically diagn ...
DOI:
10.1177/0300985820908792

17. Capacity of two Staphylococcus aureus strains with different adaptation genotypes to persist and induce damage in bovine mammary epithelial cells and to activate macrophages

Author:
Sacco, Sofía C.; Velázquez, Natalia S.; Renna, María S.; Beccaria, Camila; Baravalle, Celina; Pereyra, Elizabet A.L.; Monecke, Stefan; Calvinho, Luis F.; Dallard, Bibiana E.
Source:
Microbial pathogenesis 2020 v.142 pp. 104017
ISSN:
0882-4010
Subject:
mammary glands,   etc   ; Staphylococcus aureus; apoptosis; bacteria; biofilm; bovine mastitis; cattle; epithelial cells; genotype; herds; macrophages; pathogenesis; polysaccharides; reactive oxygen species; regulator genes; secretion; virulence;     Show all 17 Subjects
Abstract:
... The aim of this study was to evaluate and compare the ability to adhere/internalize, persist, and induce damage in mammary epithelial cells (MAC-T) of two Staphylococcus aureus strains with different adaptation genotypes (low and high) to the bovine mammary gland (MG). Also, the phagocytic and bactericidal capacity induced after the interaction between macrophages, isolated from mammary secretion, ...
DOI:
10.1016/j.micpath.2020.104017

18. Production of biologically active human factor IX-Fc fusion protein in the milk of transgenic mice

Author:
Yan, Hong; Gong, Xiuli; Xu, Miao; Guo, Xinbing; Chen, Yanwen; Xue, Yan; Zeng, Yitao; Zeng, Fanyi
Source:
Biotechnology letters 2020 v.42 no.5 pp. 717-726
ISSN:
0141-5492
Subject:
mammary glands,   etc   ; bioactive properties; blood; fluorescent antibody technique; hemophilia; humans; immunoglobulin G; mice; milk; reverse transcriptase polymerase chain reaction; transgenic animals;     Show all 11 Subjects
Abstract:
... OBJECTIVE: To investigate the feasibility of producing human IgG1 Fc fragment fused factor IX (FIX-Fc) in the milk of transgenic animals, for an alternative possible solution to the unmet need of FIX-Fc products for hemophilia B treatment. RESULTS: Six founder lines of transgenic mice harboring FIX-Fc cassette designed to be expressed specifically in the mammary gland were generated. FIX-Fc protei ...
DOI:
10.1007/s10529-020-02808-1

19. Epithelial-adipocyte interactions are required for mammary gland development, but not for milk production or fertility

Author:
Brenot, Audrey; Hutson, Irina; Harris, Charles
Source:
Developmental biology 2020 v.458 no.2 pp. 153-163
ISSN:
0012-1606
Subject:
mammary glands,   etc   ; adipose tissue; animal disease models; epithelium; estradiol; genes; leptin; mammary development; mice; milk; milk production; milk proteins; mutation; obesity; pellets; pregnancy; pups; triacylglycerols; weaning;     Show all 19 Subjects
Abstract:
... To investigate the role of adipose tissue in reproductive function and mammary gland development and function, we have examined lipodystrophic (LD) mice. LD mice of both sexes are sterile, but fertility can be restored with leptin injections. Mammary glands from lipodystrophic mice were rudimentary and lacked terminal end buds. Leptin-injected LD mice were able to become pregnant, showed normal pr ...
DOI:
10.1016/j.ydbio.2019.11.001
PubMed:
31697938
PubMed Central:
PMC6995771

20. 5-Hydroxy-l-tryptophan Promotes the Milk Calcium Level via the miR-99a-3p/ATP2B1 Axis in Goat Mammary Epithelial Cells

Author:
Chen, Shunxin; Zhao, Haiying; Yan, Xiaoru; Zhang, Zhifei; Hu, Kaizhao; Gao, Huijie; Du, Wei; Luo, Jun; Zheng, Huiling
Source:
Journal of agricultural and food chemistry 2020 v.68 no.10 pp. 3277-3285
ISSN:
1520-5118
Subject:
mammary glands,   etc   ; 5-hydroxytryptophan; bioinformatics; calcium; colostrum; dairy goats; enzymes; epithelial cells; genes; homeostasis; milk; quantitative polymerase chain reaction; sequence analysis; serotonin; transcriptomics;     Show all 15 Subjects
Abstract:
... 5-Hydroxy-l-tryptophan (5-HTP) is the primary product that converts l-tryptophan into 5-hydroxytryptamine by a rate-limiting enzyme. Our previous study found that 5-HTP could promote the intracellular calcium level in goat mammary epithelial cells (GMECs). Herein, first, dairy goats were injected with 5-HTP or saline daily from 7 days before delivery, and the calcium level in colostrum of 5-HTP-in ...
DOI:
10.1021/acs.jafc.9b07869