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1. Cross-linking/mass spectrometry to get a closer view on protein interaction networks

Author:
Iacobucci, Claudio; Götze, Michael; Sinz, Andrea
Source:
Current opinion in biotechnology 2020 v.63 pp. 48-53
ISSN:
0958-1669
Subject:
mass spectrometry,   etc   ; bioinformatics; crosslinking;     Show all 3 Subjects
Abstract:
... Just recently, chemical cross-linking combined with mass spectrometry (XL-MS) has emerged as valuable tool to study protein interaction networks on the system-wide level. The current challenges in XL-MS are to develop robust workflows enabling a comprehensive capture of dynamic biological assemblies in their native environment in a routine manner. In this review, we will highlight both the latest ...
DOI:
10.1016/j.copbio.2019.12.009

2. Label-free MS/MS analyses of the dinoflagellate Lingulodinium identifies rhythmic proteins facilitating adaptation to a diurnal LD cycle

Author:
Bowazolo, Carl; Tse, Sirius P.K.; Beauchemin, Mathieu; Lo, Samuel C.-L.; Rivoal, Jean; Morse, David
Source:
The Science of the total environment 2020 v.704 pp. 135430
ISSN:
0048-9697
Subject:
tandem mass spectrometry,   etc   ; Miozoa; proteins;     Show all 3 Subjects
Abstract:
... Protein levels were assessed in the dinoflagellate Lingulodinium polyedra over the course of a diurnal cycle using a label-free LC-MS/MS approach. Roughly 1700 proteins were quantitated in a triplicate dataset over a daily period, and 13 were found to show significant rhythmic changes. Included among the proteins found to be most abundant at night were the two bioluminescence proteins, luciferase ...
DOI:
10.1016/j.scitotenv.2019.135430

3. Ion Mobility Mass Spectrometry as an Efficient Tool for Identification of Streptorubin B in Streptomyces coelicolor M145

Author:
Marshall, Andrew P.; Johnson, Andrew R.; Vega, Marvin M.; Thomson, Regan J.; Carlson, Erin E.
Source:
Journal of natural products 2020 v.83 no.1 pp. 159-163
ISSN:
1520-6025
Subject:
mass spectrometry,   etc   ; Streptomyces coelicolor; antibiotics;     Show all 3 Subjects
Abstract:
... Ion mobility spectrometry was utilized to corroborate the identity of streptorubin B (2) as the natural product produced by Streptomyces coelicolor. Natural product 2 was initially assigned as butylcycloheptylprodigiosin (3), and only relatively recently was this assignment clarified. We present additional evidence of this assignment by comparing collisional cross sections (Ω) of synthetic standar ...
DOI:
10.1021/acs.jnatprod.9b00828
PubMed:
31904955
PubMed Central:
PMC7045693

4. Improving glycan isomeric separation via metal ion incorporation for drift tube ion mobility-mass spectrometry

Author:
Xie, Chengyi; Wu, Qidi; Zhang, Shulei; Wang, Chenlu; Gao, Wenqing; Yu, Jiancheng; Tang, Keqi
Source:
Talanta 2020 v.211 pp. 120719
ISSN:
0039-9140
Subject:
mass spectrometry,   etc   ; calcium; glycosylation; ions; polysaccharides; proteins;     Show all 6 Subjects
Abstract:
... Glycosylated proteins are an essential class of molecules playing critical roles in complex biological systems. Understanding their biological functions remains extremely difficult due to the extremely broad compositions and structure variations of glycans. Although the combination of ion mobility spectrometry and mass spectrometry (IMS-MS) has become a promising technique in glycan structure char ...
DOI:
10.1016/j.talanta.2020.120719

5. Analysis of emerging per- and polyfluoroalkyl substances: Progress and current issues

Author:
Pan, Yitao; Wang, Jinghua; Yeung, Leo W.Y.; Wei, Si; Dai, Jiayin
Source:
Trends in analytical chemistry 2020 v.124 pp. 115481
ISSN:
0165-9936
Subject:
mass spectrometry,   etc   ; gas chromatography; perfluorocarbons; toxicity;     Show all 4 Subjects
Abstract:
... The increasingly stringent restrictions on legacy per- and polyfluoroalkyl substances (PFASs) have led to the compensatory use of new fluorinated replacements. These new compounds, hereafter referred to as emerging PFASs, continue to be discovered and are now showing ubiquity in abiotic and biotic environments. Thus, there is an urgent need for robust, yet sensitive analytical methods to determine ...
DOI:
10.1016/j.trac.2019.04.013

6. Molecularly imprinted polymers for miniaturized sample preparation techniques: strategies for chromatographic and mass spectrometry methods

Author:
Santos, H.; Martins, R. O.; Soares, D. A.; Chaves, A. R.
Source:
Analytical methods 2020 v.12 no.7 pp. 894-911
ISSN:
1759-9679
Subject:
mass spectrometry,   etc   ; chromatography; molecular imprinting; polymers;     Show all 4 Subjects
Abstract:
... Analytical methods, especially miniaturized sample preparation methods, have seen technological progress with the use of molecularly imprinted polymers (MIPs). MIPs are polymers with specific sites for analyte recognition. They are combined with sample preparation at small scales for analyses with greater specificities and sensitivity. This review aims to provide an overview of current MIP researc ...
DOI:
10.1039/c9ay02227a

7. A Universal Score for Deconvolution of Intact Protein and Native Electrospray Mass Spectra

Author:
Marty, Michael T.
Source:
Analytical chemistry 2020 v.92 no.6 pp. 4395-4401
ISSN:
1520-6882
Subject:
mass spectrometry,   etc   ; algorithms; data analysis; proteomics;     Show all 4 Subjects
Abstract:
... The growing use of intact protein mass analysis, top-down proteomics, and native mass spectrometry have created a need for improved data analysis pipelines for deconvolution of electrospray (ESI) mass spectra containing multiple charge states and potentially without isotopic resolution. Although there are multiple deconvolution algorithms, there is no consensus for how to judge the quality of the ...
DOI:
10.1021/acs.analchem.9b05272

8. Correction to: Direct quantitation of tenofovir diphosphate in human blood with mass spectrometry for adherence monitoring

Author:
Pu, Fan; Pandey, Sangeeta; Bushman, Lane R.; Anderson, Peter L.; Ouyang, Zheng; Cooks, R. Graham
Source:
Analytical and bioanalytical chemistry 2020 v.412 no.6 pp. 1465
ISSN:
1618-2642
Subject:
mass spectrometry,   etc   ; blood; chemical structure; humans; monitoring;     Show all 5 Subjects
Abstract:
... Unfortunately, after online publication, a formatting mistake was found in Table 1 (Chemical structures and MRM transitions used for quantitation). The original article has been corrected. ...
DOI:
10.1007/s00216-020-02402-4

9. Degradation studies of dimethachlor in soils and water by UHPLC‐HRMS: putative elucidation of unknown metabolites

Author:
López‐Ruiz, Rosalía; Romero‐González, Roberto; Ortega‐Carrasco, Elisabeth; Martínez Vidal, José L; Garrido Frenich, Antonia
Source:
Pest management science 2020 v.76 no.2 pp. 721-729
ISSN:
1526-498X
Subject:
mass spectrometry,   etc   ; computer software; dimethachlor; metabolites; soil;     Show all 5 Subjects
Abstract:
... Degradation of dimethachlor was evaluated in soils and water, detecting metabolites in incurred samples. Putative elucidation was performed using HRMS and software tools, detecting new possible metabolites of dimethachlor. ...
DOI:
10.1002/ps.5570

10. Sources of overestimation in the analysis of acrylamide-in coffee by liquid chromatography mass spectrometry

Author:
Desmarchelier, Aurélien; Hamel, Jonas; Delatour, Thierry
Source:
Journal of chromatography 2020 v.1610 pp. 460566
ISSN:
0021-9673
Subject:
tandem mass spectrometry,   etc   ; acrylamides; ions; liquid chromatography;     Show all 4 Subjects
Abstract:
... Analysis of acrylamide in coffee by liquid chromatography-tandem mass spectrometry (LC-MS/MS) is prone to interferences. According to our study, unknown background ions can entail an overestimation by up to 40% in case of coelution with acrylamide. In order to develop a precise and accurate quantification method for acrylamide, identification and removal of these interfering ions is requested. We ...
DOI:
10.1016/j.chroma.2019.460566

11. Strategies for Development of a Next-Generation Protein Sequencing Platform

Author:
Callahan, Nicholas; Tullman, Jennifer; Kelman, Zvi; Marino, John
Source:
Trends in biochemical sciences 2020 v.45 no.1 pp. 76-89
ISSN:
0968-0004
Subject:
mass spectrometry,   etc   ; antibodies; genes; peptides; proteome; proteomics;     Show all 6 Subjects
Abstract:
... Proteomic analysis can be a critical bottleneck in cellular characterization. The current paradigm relies primarily on mass spectrometry of peptides and affinity reagents (i.e., antibodies), both of which require a priori knowledge of the sample. An unbiased protein sequencing method, with a dynamic range that covers the full range of protein concentrations in proteomes, would revolutionize the fi ...
DOI:
10.1016/j.tibs.2019.09.005

12. Sample-multiplexing by derivatization using multiple analogous reagents for enhancing throughput in LC/ESI-MS/MS assay of steroids: Plasma 17α-hydroxyprogesterone as an example

Author:
Kamemura, Miki; Yokota, Mai; Ogawa, Shoujiro; Sugiura, Takahiro; Higashi, Tatsuya
Source:
Journal of chromatography 2020 v.1146 pp. 122117
ISSN:
1570-0232
Subject:
electrospray ionization mass spectrometry; tandem mass spectrometry,   etc   ; derivatization; enzymes; liquid chromatography; models; steroids;     Show all 7 Subjects
Abstract:
... The measurements of steroids in biological fluids are of importance for the diagnosis and treatment of many diseases. Liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) has a high specificity and accuracy for the steroid analysis, whereas it has a lower analysis throughput, which could become a big issue in clinical practice. One of the promising solutions to thi ...
DOI:
10.1016/j.jchromb.2020.122117

13. Systematic mapping of protein–metabolite interactions with mass spectrometry-based techniques

Author:
Li, Shanshan; Shui, Wenqing
Source:
Current opinion in biotechnology 2020 v.64 pp. 24-31
ISSN:
0958-1669
Subject:
mass spectrometry,   etc   ; catalytic activity; eukaryotic cells; metabolites; metabolomics; proteins; proteomics;     Show all 7 Subjects
Abstract:
... The recent rapid advance of systematic mapping of protein–metabolite interactions (PMIs) in both prokaryotic and eukaryotic cells has been catalyzed by development of innovative and effective proteomics or metabolomics strategies all based on large-scale mass spectrometry (MS) analysis of biomolecules. Both metabolite-centric and protein-centric approaches have been established to profile PMIs in ...
DOI:
10.1016/j.copbio.2019.09.002

14. A non-targeted high-resolution mass spectrometry approach for the assessment of the geographical origin of durum wheat

Author:
Cavanna, Daniele; Loffi, Cecilia; Dall'Asta, Chiara; Suman, Michele
Source:
Food chemistry 2020 v.317 pp. 126366
ISSN:
0308-8146
Subject:
mass spectrometry,   etc   ; durum wheat; pasta; provenance; raw materials;     Show all 5 Subjects
Abstract:
... The assessment of durum wheat geographical origin is an important and emerging challenge, due to the added value that a claim of origin could provide to the raw material itself, and subsequently to the final products (i.e. pasta).Up to now, the typical approach presented in literature is the evaluation of different isotopic ratios of the elements, but other techniques could represent an interestin ...
DOI:
10.1016/j.foodchem.2020.126366

15. Pretreatment and non-specific binding in ultrafiltration device: Impact on protease inhibitor quantification

Author:
Castro, Thales Nascimento e; Costa, Edlaine Rijo; Gonçalves, José Carlos Saraiva; Estrela, Rita de Cassia Elias
Source:
Journal of chromatography 2020 v.1146 pp. 122127
ISSN:
1570-0232
Subject:
mass spectrometry,   etc   ; drugs; enzymes; liquid chromatography; polysorbates; proteinase inhibitors; ultrafiltration;     Show all 7 Subjects
Abstract:
... Ultrafiltration (UF) is used to separate unbound drugs; however, non-specific binding (NSB) may be a limiting factor of this technique. Pretreatment of UF devices has been suggested to reduce NSB. Therefore, the pretreatment methodologies for UF devices were evaluated in order to test their effectiveness in reducing NSB of protease inhibitors (PIs).Two PIs (lopinavir-LPV and ritonavir-RTV) were te ...
DOI:
10.1016/j.jchromb.2020.122127

16. Recent advances in single-cell ultra-trace analysis

Author:
Wei, Xing; Lu, Yi; Zhang, Xuan; Chen, Ming-Li; Wang, Jian-Hua
Source:
Trends in analytical chemistry 2020 v.127 pp. 115886
ISSN:
0165-9936
Subject:
mass spectrometry,   etc   ; calibration; detection limit; electrochemistry; statistical analysis;     Show all 5 Subjects
Abstract:
... Currently, single-cell analysis has become increasingly important. It can reveal cell-to-cell variances in a heterogeneous cell population and obtain a rare but important cytological information. Statistical analysis of cell populations based on single cell analysis results in a more realistic state of cell distribution, which is more conducive to biochemical and biomedical development than tradit ...
DOI:
10.1016/j.trac.2020.115886

17. Non-targeted discovery-based analysis for gas chromatography with mass spectrometry: A comparison of peak table, tile, and pixel-based Fisher ratio analysis

Author:
Freye, Chris E.; Bowden, Patrick R.; Greenfield, Margo T.; Tappan, Bryce C.
Source:
Talanta 2020 v.211 pp. 120668
ISSN:
0039-9140
Subject:
gas chromatography-mass spectrometry,   etc   ; algorithms; computer software; data collection; gasoline;     Show all 5 Subjects
Abstract:
... The ability to discover minute differences between samples or sample classes for gas chromatography coupled to mass spectrometry (GC-MS) can be a challenging endeavor, especially when those differences are not a priori. Fisher ratio (F-ratio) analysis is an apt technique to probe the differences between GC-MS chromatograms. F-ratio analysis is a supervised, non-targeted, discovery-based method tha ...
DOI:
10.1016/j.talanta.2019.120668

18. Expansion and improvement of MALDI-TOF MS databases for accurate identification of Achromobacter species

Author:
Papalia, Mariana; Figueroa-Espinosa, Roque; Steffanowski, Carla; Barberis, Claudia; Almuzara, Marisa; Barrios, Rubén; Vay, Carlos; Gutkind, Gabriel; Di Conza, José; Radice, Marcela
Source:
Journal of microbiological methods 2020 v.172 pp. 105889
ISSN:
0167-7012
Subject:
matrix-assisted laser desorption-ionization mass spectrometry,   etc   ; Achromobacter; databases;     Show all 3 Subjects
Abstract:
... Different MALDI-TOF MS databases were evaluated for the identification of Achromobacter species. The in-house and extended database generated in this study rendered more accurate identification (58/64 and 57/64 isolates, respectively) in comparison with the Bruker commercial database (42/64 isolates), especially in those infrequent species that are not available or poorly represented. ...
DOI:
10.1016/j.mimet.2020.105889

19. Determination of Sudan dyes in chili products by micellar electrokinetic chromatography-MS/MS using a volatile surfactant

Author:
Moreno-González, David; Jáč, Pavel; Švec, František; Nováková, Lucie
Source:
Food chemistry 2020 v.310 pp. 125963
ISSN:
0308-8146
Subject:
tandem mass spectrometry,   etc   ; Sudan dyes; acetonitrile; cleaning; standard deviation; surfactants;     Show all 6 Subjects
Abstract:
... A new MEKC-MS/MS method was developed for the determination of four Sudan dyes in chili products. The separation and MS detection conditions were optimized to achieve fast, efficient, selective, and sensitive determination of Sudan I, Sudan II, Sudan III, and Sudan IV dyes. The target compounds were extracted from chili samples with acetonitrile and cleaned by freeze-out. This two-step sample prep ...
DOI:
10.1016/j.foodchem.2019.125963

20. A surface-enhanced Raman spectroscopy database of 63 metabolites

Author:
Sherman, Lindy M.; Petrov, Alexander P.; Karger, Leonhard F.P.; Tetrick, Maxwell G.; Dovichi, Norman J.; Camden, Jon P.
Source:
Talanta 2020 v.210 pp. 120645
ISSN:
0039-9140
Subject:
mass spectrometry,   etc   ; Raman spectroscopy; databases; metabolites; metabolomics; nanosilver;     Show all 6 Subjects
Abstract:
... Metabolomics, the study of metabolic profiles in a biological sample, has seen rapid growth due to advances in measurement technologies such as mass spectrometry (MS). While MS metabolite reference libraries have been generated for metabolomics applications, mass spectra alone are unable to unambiguously identify many metabolites in a sample; these unidentified compounds are typically annotated as ...
DOI:
10.1016/j.talanta.2019.120645
PubMed:
31987216
PubMed Central:
PMC6989628