U.S. flag

An official website of the United States government

PubAg

Main content area

You searched for: Subject "mass spectrometry" Remove constraint Subject: "mass spectrometry"
Start Over

Search

94,628  Search Results

« Previous | 1 - 20 of 94,628 |
Number of results to display per page

Search Results

1. FT-ICR mass spectrometry for molecular characterization of water-insoluble organic compounds in winter atmospheric fine particulate matters

Author:
Ning, Cuiping; Gao, Yuan; Yu, Haoran; Zhang, Haijun; Geng, Ningbo; Cao, Rong; Chen, Jiping
Source:
Journal of environmental sciences (China) 2022 v.111 pp. 51-60
ISSN:
1001-0742
Subject:
mass spectrometry,   etc   ; atmospheric pressure; climate; human health; methylene chloride; water solubility; China;     Show all 7 Subjects
Abstract:
... Water-insoluble organic compounds (WIOCs) are an important fraction of atmospheric fine particulate matters (PM₂.₅), which could affect the climate system and threaten human health potentially. In this study, molecular characterization of WIOCs in PM₂.₅ were investigated by 15 T Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) with atmospheric pressure photoionization (APPI) ...
DOI:
10.1016/j.jes.2020.12.017

2. Radiocarbon Dating of Marine Samples: Methodological Aspects, Applications and Case Studies

Author:
Quarta, Gianluca; Maruccio, Lucio; D’Elia, Marisa; Calcagnile, Lucio
Source:
Water 2021 v.13 no.7
ISSN:
2073-4441
Subject:
mass spectrometry,   etc   ; sea level; water;     Show all 3 Subjects
Abstract:
... Radiocarbon dating by AMS (Accelerator Mass Spectrometry) is a well-established absolute dating technique widely used in different areas of research for the analysis of a wide range of organic materials. Precision levels of the order of 0.2–0.3% in the measured age are nowadays achieved while several international intercomparison exercises have shown the high degree of reproducibility of the resul ...
DOI:
10.3390/w13070986

3. Improving Spectral Validation Rates in Hydrogen–Deuterium Exchange Data Analysis

Author:
Raval, Shaunak; Sarpe, Vladimir; Hepburn, Morgan; Crowder, D. Alex; Zhang, Terry; Viner, Rosa; Schriemer, David C.
Source:
Analytical chemistry 2021 v.93 no.9 pp. 4246-4254
ISSN:
1520-6882
Subject:
mass spectrometry,   etc   ; analytical chemistry; peptides;     Show all 3 Subjects
Abstract:
... The data analysis practices associated with hydrogen–deuterium exchange mass spectrometry (HX-MS) lag far behind that of most other MS-based protein analysis tools. A reliance on external tools from other fields and a persistent need for manual data validation restrict this powerful technology to the expert user. Here, we provide an extensive upgrade to the HX data analysis suite available in the ...
DOI:
10.1021/acs.analchem.0c05045

4. Ion mobility-mass spectrometry shows stepwise protein unfolding under alkaline conditions

Author:
Sahin, Cagla; Österlund, Nicklas; Leppert, Axel; Johansson, Jan; Marklund, Erik G.; Benesch, Justin L. P.; Ilag, Leopold L.; Allison, Timothy M.; Landreh, Michael
Source:
Chemical communications 2021 v.57 no.12 pp. 1450-1453
ISSN:
1364-548X
Subject:
mass spectrometry,   etc   ; pH; protein denaturation;     Show all 3 Subjects
Abstract:
... Although native mass spectrometry is widely applied to monitor chemical or thermal protein denaturation, it is not clear to what extent it can inform about alkali-induced unfolding. Here, we probe the relationship between solution- and gas-phase structures of proteins under alkaline conditions. Native ion mobility-mass spectrometry reveals that globular proteins are destabilized rather than global ...
DOI:
10.1039/d0cc08135c

5. Application of Comprehensive 2D Chromatography in the Anti-Doping Field: Sample Identification and Quantification

Author:
Hand, Rachel A.; Bassindale, Thomas; Turner, Nicholas; Morgan, Geraint
Source:
Journal of chromatography 2021 pp. 122584
ISSN:
1570-0232
Subject:
mass spectrometry,   etc   ; chromatography; data collection;     Show all 3 Subjects
Abstract:
... Anti-doping analysis requires an exceptional level of accuracy and precision given the stakes that are at play. Current methods rely on the application of chromatographic techniques linked with mass spectrometry to provide this. However, despite the effectiveness of these techniques in achieving good selectivity and specificity, some issues still exist. In order to reach the minimum required perfo ...
DOI:
10.1016/j.jchromb.2021.122584

6. Development of an analytical method based on solid-phase extraction and LC-MS/MS for the monitoring of current-use pesticides and their metabolites in human urine

Author:
Gao, Beibei; Poma, Giulia; Malarvannan, Govindan; Dumitrascu, Catalina; Bastiaensen, Michiel; Wang, Minghua; Covaci, Adrian
Source:
Journal of environmental sciences (China) 2022 v.111 pp. 153-163
ISSN:
1001-0742
Subject:
tandem mass spectrometry,   etc   ; acetamiprid; bifenthrin; chemical species; chlorpyrifos; chlorpyrifos-methyl; cyfluthrin; cypermethrin; deltamethrin; dicarboxylic acids; environmental monitoring; fipronil; humans; imidacloprid; liquid chromatography; malathion; metabolites; permethrin; pyrethrins; solid phase extraction; thiacloprid; triazoles; urine; China;     Show all 24 Subjects
Abstract:
... Pyrethroids, organophosphorus pesticides and fipronil have been listed as priority chemicals in human biomonitoring studies because of their wide use and potential health effects in humans. The determination of 13 pesticides, including pyrethroids (deltamethrin, cypermethrin, permethrin, cyfluthrin, bifenthrin), organophosphorus (chlorpyrifos, chlorpyrifos-methyl, and malathion), fipronil, neonico ...
DOI:
10.1016/j.jes.2021.03.029

7. One-minute highly selective Cr(VI) determination at ultra-trace levels: An ICP-MS method based on the on-line trapping of Cr(III)

Author:
Spanu, Davide; Monticelli, Damiano; Binda, Gilberto; Dossi, Carlo; Rampazzi, Laura; Recchia, Sandro
Source:
Journal of hazardous materials 2021 v.412 pp. 125280
ISSN:
0304-3894
Subject:
mass spectrometry,   etc   ; chromatography; cost effectiveness; mineral water;     Show all 4 Subjects
Abstract:
... An analytical method derived from the coupling of frontal chromatography (FC) with Inductively Coupled Plasma – Mass Spectrometry (ICP-MS) is proposed for the fast determination of Cr(VI) ultra-traces. The insertion of a short, homemade column filled with a strong cationic exchange resin in the flow-path of a commercial ICP-MS allows on-line trapping of cationic Cr(III) and elution of anionic Cr(V ...
DOI:
10.1016/j.jhazmat.2021.125280

8. WDR35 is involved in subcellular localization of acetylated tubulin in 293T cells

Author:
Sekiguchi, Takeshi; Ishii, Takashi; Kobayashi, Hideki; Furuno, Nobuaki
Source:
Biochemical and biophysical research communications 2021 v.547 pp. 169-175
ISSN:
0006-291X
Subject:
mass spectrometry,   etc   ; research; transport proteins; tubulin;     Show all 4 Subjects
Abstract:
... WDR35/IFT121 is an intraflagellar transport protein in primary cilia, which is associated with RagA, an mTORC1-activating protein. To elucidate the functions of the interaction between WDR35 and RagA in primary cilia, as well as mTOR signaling, we identified WDR35-interacting proteins using mass spectrometry. We found that WDR35 associates with CCT complex proteins including TCP1/CCT1, which act a ...
DOI:
10.1016/j.bbrc.2021.01.092

9. Understanding of TEMPO-electrocatalyzed acceptorless dehydrogenation of tetrahydroquinoline by in situ extractive electrospray ionization mass spectrometry

Author:
Li, Weixiang; Sun, Jianghui; Wang, Yan; Qiao, Jinping; He, Lixin; Ouyang, Jin; Na, Na
Source:
Chemical communications 2021 v.57 no.23 pp. 2955-2958
ISSN:
1364-548X
Subject:
electrospray ionization mass spectrometry,   etc   ; dehydrogenation; hydrogen;     Show all 3 Subjects
Abstract:
... The TEMPO-electrocatalyzed acceptorless dehydrogenation of tetrahydroquinoline, a transformation in green synthesis and hydrogen storage, has been investigated by coupling of an electrocatalytic system with in situ extraction electrospray ionization mass spectrometry. Dynamic changes in important species and intermediates were monitored, which evoked an updated AD understanding. ...
DOI:
10.1039/d0cc08209k

10. XlinkCyNET: A Cytoscape Application for Visualization of Protein Interaction Networks Based on Cross-Linking Mass Spectrometry Identifications

Author:
Lima, Diogo Borges; Zhu, Ying; Liu, Fan
Source:
Journal of proteome research 2021 v.20 no.4 pp. 1943-1950
ISSN:
1535-3907
Subject:
mass spectrometry,   etc   ; computer software; crosslinking; proteome; research;     Show all 5 Subjects
Abstract:
... Software tools that allow the visualization and analysis of protein interaction networks are essential for studies in systems biology. One of the most popular network visualization tools in biology is Cytoscape, which offers a great selection of plug-ins for the interpretation of network data. Chemical cross-linking coupled to mass spectrometry (XL-MS) is an increasingly important source for prote ...
DOI:
10.1021/acs.jproteome.0c00957

11. A review on analytical methods for pharmaceutical and personal care products and their transformation products

Author:
Meng, Yuan; Liu, Weiyi; Liu, Xiaohui; Zhang, Jinlan; Peng, Meng; Zhang, Tingting
Source:
Journal of environmental sciences (China) 2021 v.101 pp. 260-281
ISSN:
1001-0742
Subject:
mass spectrometry,   etc   ; adsorbents; chromatography; ionization; toxicity; China;     Show all 6 Subjects
Abstract:
... Pharmaceutical and personal care products (PPCPs) and corresponding transformation products have caused widespread concern due to their persistent emissions and potential toxicity. They have wide octanol-water partition coefficients (Kₒw) and different ionization constants (pKₐ) resulting in a poor analysis accuracy and efficiency. A suitable analytical method is the first prerequisite for further ...
DOI:
10.1016/j.jes.2020.08.025

12. Differentiation of Italian extra virgin olive oils by rapid evaporative ionization mass spectrometry

Author:
Mangraviti, Domenica; Rigano, Francesca; Arigò, Adriana; Dugo, Paola; Mondello, Luigi
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2021 v.138 pp. 110715
ISSN:
0023-6438
Subject:
mass spectrometry,   etc   ; ; chemometrics; cultivars; databases; liquids;     Show all 6 Subjects
Abstract:
... The present work aims to differentiate Italian extra virgin olive oils through the analysis of about 100 samples for the building of a spectral database useful for the comparison beetwen top-quality oils. High-quality oils belonging to two different harvest years and coming from different Italian regions, labelled as PDO (Protected Denomination of Origin) or obtained from a single variety of olive ...
DOI:
10.1016/j.lwt.2020.110715

13. The history of electron ionization in LC-MS, from the early days to modern technologies: A review

Author:
Famiglini, Giorgio; Palma, Pierangela; Termopoli, Veronica; Cappiello, Achille
Source:
Analytica chimica acta 2021 pp. 338350
ISSN:
0003-2670
Subject:
gas chromatography-mass spectrometry,   etc   ; ionization; liquid chromatography;     Show all 3 Subjects
Abstract:
... This review article traces the history of the use of liquid chromatography coupled with mass spectrometry (LC-MS) using electron ionization (EI) from the first attempts up to the present day. At the time of the first efforts to couple LC to MS, 70 eV EI was the most common ionization technique, typically used in gas chromatography-mass spectrometry (GC-MS) and providing highly reproducible mass sp ...
DOI:
10.1016/j.aca.2021.338350

14. Interactive Estimation of Heterogeneity from Mass Spectrometry Imaging

Author:
Zhvansky, Evgeny S.; Ivanov, Daniil G.; Sorokin, Anatoly A.; Bugrova, Anna E.; Nikolaev, Evgeny N.; Popov, Igor A.
Source:
Analytical chemistry 2021 v.93 no.8 pp. 3706-3709
ISSN:
1520-6882
Subject:
mass spectrometry,   etc   ; analytical chemistry; brain; histology; mice;     Show all 5 Subjects
Abstract:
... In this work, we demonstrate a new approach for interactively assessing hyperspectral data spatial structures for heterogeneity using mass spectrometry imaging. This approach is based on the visualization of the cosine distance as the similarity levels between mass spectra of a chosen region and the rest of the image (sample). The applicability of the method is demonstrated on a set of mass spectr ...
DOI:
10.1021/acs.analchem.1c00437

15. Rapid Distinction and Semiquantitative Analysis of THC and CBD by Silver-Impregnated Paper Spray Mass Spectrometry

Author:
Huang, Si; Claassen, Frank W.; van Beek, Teris A.; Chen, Bo; Zeng, Jianguo; Zuilhof, Han; Salentijn, Gert IJ.
Source:
Analytical chemistry 2021 v.93 no.8 pp. 3794-3802
ISSN:
1520-6882
Subject:
mass spectrometry,   etc   ; analytical chemistry; cannabidiol; methanol; paper;     Show all 5 Subjects
Abstract:
... The control over the amount of psychoactive THC (Δ-9-tetrahydrocannabinol) in commercial cannabidiol (CBD) products has to be strict. A fast and simple semiquantitative Ag(I)-impregnated paper spray mass spectrometric method for differentiating between THC and CBD, which show no difference in standard single-stage or tandem MS, was established. Because of a different binding affinity to Ag(I) ions ...
DOI:
10.1021/acs.analchem.0c04270

16. Correspondence-Aware Manifold Learning for Microscopic and Spatial Omics Imaging: A Novel Data Fusion Method Bringing Mass Spectrometry Imaging to a Cellular Resolution

Author:
Smets, Tina; De Keyser, Tom; Tousseyn, Thomas; Waelkens, Etienne; De Moor, Bart
Source:
Analytical chemistry 2021 v.93 no.7 pp. 3452-3460
ISSN:
1520-6882
Subject:
mass spectrometry,   etc   ; analytical chemistry; eosin; prediction;     Show all 4 Subjects
Abstract:
... High-dimensional molecular measurements are transforming the field of pathology into a data-driven discipline. While hematoxylin and eosin (H&E) stainings are still the gold standard to diagnose diseases, the integration of microscopic and molecular information is becoming crucial to advance our understanding of tissue heterogeneity. To this end, we propose a data fusion method that integrates spa ...
DOI:
10.1021/acs.analchem.0c04759

17. Reaction Tracking and High-Throughput Screening of Active Compounds in Combinatorial Chemistry by Tandem Mass Spectrometry Molecular Networking

Author:
Chung, Hsin-Hsiang; Kao, Chih-Yao; Wang, Tsung-Shing Andrew; Chu, John; Pei, Jiying; Hsu, Cheng-Chih
Source:
Analytical chemistry 2021 v.93 no.4 pp. 2456-2463
ISSN:
1520-6882
Subject:
tandem mass spectrometry,   etc   ; active ingredients; analytical chemistry;     Show all 3 Subjects
Abstract:
... Combinatorial synthesis has been widely used as an efficient strategy to screen for active compounds. Mass spectrometry is the method of choice in the identification of hits resulting from high-throughput screenings due to its high sensitivity, specificity, and speed. However, manual data processing of mass spectrometry data, especially for structurally diverse products in combinatorial chemistry, ...
DOI:
10.1021/acs.analchem.0c04481

18. Capillary ultrahigh-pressure liquid chromatography-mass spectrometry for fast and high resolution metabolomics separations

Author:
Sorensen, Matthew J.; Kennedy, Robert T.
Source:
Journal of chromatography 2021 v.1635 pp. 461706
ISSN:
0021-9673
Subject:
mass spectrometry,   etc   ; metabolites; metabolomics; particle size;     Show all 4 Subjects
Abstract:
... LC-MS is an important tool for metabolomics due its high sensitivity and broad metabolite coverage. The goal of improving resolution and decreasing analysis time in HPLC has led to the use of 5 – 15 cm long columns packed with 1.7 – 1.9 µm particles requiring pressures of 8 – 12 kpsi. We report on the potential for capillary LC-MS based metabolomics utilizing porous C18 particles down to 1.1 µm di ...
DOI:
10.1016/j.chroma.2020.461706

19. A holistic strategy for discovering structural analogues of drug residues in meat using characteristic structural fragments filtering by high-resolution Orbitrap mass spectrometry

Author:
Liu, Xiao-Min; Xu, Xiu-Li; Nie, Xue-Mei; Feng, Xue-Song; Zhang, Feng
Source:
Food additives & contaminants 2021 v.38 no.1 pp. 81-94
ISSN:
1944-0057
Subject:
mass spectrometry,   etc   ; ; benzimidazoles; cephalosporins; filtration; meat; nitrogen;     Show all 7 Subjects
Abstract:
... A holistic strategy for discovering structural analogs was established using characteristic structural fragments filtering by high-resolution Orbitrap mass spectrometry and successfully employed for discovering potential hazards in meat. The mass spectrometry fragmentation mechanisms of 113 compounds (including sulphonamides, tetracyclines, benzimidazoles, steroid hormones, cephalosporins, β-block ...
DOI:
10.1080/19440049.2020.1825828

20. Simultaneous quantification of cefuroxime and clindamycin in human lumbar anulus fibrosus, nucleus pulposus and serum via UPLC-MS/MS

Author:
Liang, Xiufang; Gou, Zhongping; Wang, Xiandi; Wang, Yongsheng; Yue, Jiao; Li, Na; Feng, Ping; Qin, Yongping; Zeng, Jiancheng
Source:
Journal of chromatography 2021 v.1165 pp. 122522
ISSN:
1570-0232
Subject:
electrospray ionization mass spectrometry; tandem mass spectrometry,   etc   ; blood serum; cefuroxime; chemical species; clindamycin; humans; standard deviation;     Show all 8 Subjects
Abstract:
... This study aimed to develop a sensitive, accurate method for simultaneously quantifying cefuroxime and clindamycin in human serum, lumbar anulus fibrosus and nucleus pulposus.Cefuroxime and clindamycin were quantified using ultra high-performance liquid chromatography-electrospray ionization tandem mass spectrometry in multiple-reaction-monitoring mode on a triple-quadrupole AB Qtrap 5500 system i ...
DOI:
10.1016/j.jchromb.2021.122522