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1. Differential Ion Mobility–Mass Spectrometry for Detailed Analysis of the Proteome

Author:
Winter, Daniel L.; Wilkins, Marc R.; Donald, William A.
Source:
Trends in biotechnology 2019 v.37 no.2 pp. 198-213
ISSN:
0167-7799
Subject:
mass spectrometry,   etc   ; proteins; proteome; proteomics;     Show all 4 Subjects
Abstract:
... The field of proteomics is increasingly concerned with the diversity and functional relevance of protein modifications. Differential ion mobility spectrometry (DMS) is emerging as a tool to detect and quantify additional peptide and protein species that are difficult to analyse with conventional instrumental methods. In this review, recent advances in DMS are discussed, with a focus on the differe ...
DOI:
10.1016/j.tibtech.2018.07.018

2. Identification and quantification of synthetic cannabinoids in ‘spice-like’ herbal mixtures: Update of the German situation in summer 2018

Author:
Ernst, Ludger; Langer, Nico; Bockelmann, Aileen; Salkhordeh, Elaheh; Beuerle, Till
Source:
Forensic science international 2019 v.294 pp. 96-102
ISSN:
0379-0738
Subject:
electrospray ionization mass spectrometry; gas chromatography-mass spectrometry; tandem mass spectrometry,   etc   ; Internet; active ingredients; cannabinoids; nuclear magnetic resonance spectroscopy; summer;     Show all 8 Subjects
Abstract:
... In June 2018, 15 ‘Spice-like’ herbal products from German language internet shops were analyzed. In total, three different synthetic cannabinoids (SCs) were identified by gas chromatography–mass spectrometry (GC–MS). Two of the active ingredients were identified as the recently described 5F-ADB and Cumyl-PeGaClone. The third compound was identified as the so far unknown SC 5F-Cumyl-PeGaClone. 5F-C ...
DOI:
10.1016/j.forsciint.2018.11.001

3. Development and comparative analysis of yeast protein extraction protocols for mass spectrometry

Author:
Almeida, Lauana Fogaça de; Moraes, Leonardo Nazário de; Santos, Lucilene Delazari dos; Valente, Guilherme Targino
Source:
Analytical biochemistry 2019 v.567 pp. 90-95
ISSN:
0003-2697
Subject:
mass spectrometry,   etc   ; proteinase inhibitors; proteins; yeasts;     Show all 4 Subjects
Abstract:
... Mass spectrometry is the most used method for protein identification and quantification. Here we developed four protein extraction protocols precisely for mass spectrometry, and we compared with other ones already published. The best protocol developed by us consists on a simple extraction solution, a heat-shock step, and does not use protease inhibitor; moreover, it is the most efficient and unif ...
DOI:
10.1016/j.ab.2018.10.028

4. Development of a strategy for the quantification of food allergens in several food products by mass spectrometry in a routine laboratory

Author:
Planque, M.; Arnould, T.; Delahaut, P.; Renard, P.; Dieu, M.; Gillard, N.
Source:
Food chemistry 2019 v.274 pp. 35-45
ISSN:
0308-8146
Subject:
mass spectrometry,   etc   ; allergens; eggs; foods; milk; peanuts;     Show all 6 Subjects
Abstract:
... Worldwide, mass spectrometry is widely used to detect and quantify food allergens, especially in complex and processed food products. Yet, the absence of a regulatory framework for the developed methods has led to a lack of harmonization between laboratories. In this study, ten allergens were analyzed in eight food products by UHPLC–MS/MS, in order to establish criteria for the retention time, var ...
DOI:
10.1016/j.foodchem.2018.08.095

5. Approaching Standardless Quantitative Elemental Analysis of Solids: Microsecond Pulsed Glow Discharge and Buffer-Gas-Assisted Laser Ionization Time-of-Flight Mass Spectrometry

Author:
Hang, Le; Xu, Zhouyi; Yin, Zhibin; Hang, Wei
Source:
Analytical chemistry 2018 v.90 no.22 pp. 13222-13228
ISSN:
1520-6882
Subject:
mass spectrometry,   etc   ; ionization; temperature;     Show all 3 Subjects
Abstract:
... Among various ionization sources for mass spectrometry, microsecond pulsed glow discharge (MP-GD) and buffer-gas-assisted laser ionization (BGA-LI) sources have the potential for direct quantitative elemental analysis of solids without the requirement of standard reference materials. The analytical potential of these two ionization sources has been evaluated by coupling them to orthogonal time-of- ...
DOI:
10.1021/acs.analchem.8b03398

6. Nonlinear effects induced in the normalized ion density in a linear trap system for a large ion cloud

Author:
Pedrosa‐Rodriguez, Laura; Outerelo, D.A.; Diaz‐Otero, Francisco J.
Source:
Journal of mass spectrometry 2018 v.53 no.10 pp. 927-933
ISSN:
1076-5174
Subject:
mass spectrometry,   etc   ; models; temperature;     Show all 3 Subjects
Abstract:
... In this work, we design, by means of a non‐neutral plasma method, a linear trapping model for large ion clouds, which will become the core of an atomic clock. We first obtain the geometry and electromagnetic characteristics of the ion trap. We then perform a systematic analysis describing the main parameters of the ion cloud such as size, secular frequency, and ion number per unit length of temper ...
DOI:
10.1002/jms.4250

7. Direct ion generation from swabs

Author:
Jarmusch, Alan K.; Pirro, Valentina; Logsdon, David L.; Cooks, R. Graham
Source:
Talanta 2018 v.184 pp. 356-363
ISSN:
0039-9140
Subject:
mass spectrometry,   etc   ; ionization; ions;     Show all 3 Subjects
Abstract:
... Medical swabs are used for biofluid and tissue sampling in clinical applications. The use of medical swabs as electrospray ionization probes for direct mass spectrometric analysis is a novel and potentially widely applicable development. Here we discuss ion generation, characterize ionization behavior via microscopic videography and describe some illustrative examples of applications. ...
DOI:
10.1016/j.talanta.2018.02.105

8. High resolution-ion mobility mass spectrometry as an additional powerful tool for structural characterization of mycotoxin metabolites

Author:
Righetti, Laura; Fenclova, Marie; Dellafiora, Luca; Hajslova, Jana; Stranska-Zachariasova, Milena; Dall'Asta, Chiara
Source:
Food chemistry 2018 v.245 pp. 768-774
ISSN:
0308-8146
Subject:
mass spectrometry,   etc   ; metabolites; mycotoxins;     Show all 3 Subjects
Abstract:
... This work was designed as a proof of concept, to demonstrate the successful use of the comparison between theoretical and experimental collision cross section (CCS) values to support the identification of isomeric forms. To this purpose, thirteen mycotoxins were considered and analyzed using drift time ion mobility mass spectrometry. A good linear correlation (r2 = 0.962) between theoretical and e ...
DOI:
10.1016/j.foodchem.2017.11.113

9. Characterization of key aroma compounds in Chinese Guojing sesame-flavor Baijiu by means of molecular sensory science

Author:
Li, Hehe; Qin, Dan; Wu, Ziyang; Sun, Baoguo; Sun, Xiaotao; Huang, Mingquan; Sun, Jinyuan; Zheng, Fuping
Source:
Food chemistry 2019 v.284 pp. 100-107
ISSN:
0308-8146
Subject:
gas chromatography-mass spectrometry,   etc   ; flavor; octanoic acid; odor compounds; odors;     Show all 5 Subjects
Abstract:
... Key odorants of Guojing sesame-flavor Baijiu were identified using the concept of molecular sensory science, including aroma extract dilution analysis (AEDA) based on gas chromatography–olfactometry (GC–O) combined with gas chromatography-mass spectrometry (GC–MS). A total of 509 volatile compounds were detected by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry ( ...
DOI:
10.1016/j.foodchem.2019.01.102

10. MALDI-ToF mass spectrometry detection of intramolecular composition gradient in copolymers

Author:
Trhlíková, Olga; Janata, Miroslav; Walterová, Zuzana; Kanizsová, Lívia; Čadová, Eva; Horský, Jiří
Source:
Talanta 2019 v.195 pp. 215-220
ISSN:
0039-9140
Subject:
matrix-assisted laser desorption-ionization mass spectrometry,   etc   ; composite polymers; copolymerization;     Show all 3 Subjects
Abstract:
... Since their addition to the polymer-architecture portfolio, gradient copolymers have attracted significant attention. Up to now, however, the existence of the intramolecular composition gradient must have been ascertained by sampling during living copolymerization because a reliable method for the detection of the composition gradient in the finalized copolymer had not been established yet. Here w ...
DOI:
10.1016/j.talanta.2018.11.058

11. Reliable determination of tropane alkaloids in cereal based baby foods coupling on-line spe to mass spectrometry avoiding chromatographic step

Author:
Marín-Sáez, Jesús; Romero-González, Roberto; Garrido Frenich, Antonia
Source:
Food chemistry 2019 v.275 pp. 746-753
ISSN:
0308-8146
Subject:
mass spectrometry,   etc   ; Solanaceae; atropine; chromatography; diet; infant foods; scopolamine;     Show all 7 Subjects
Abstract:
... Cereal based foods are a major part of the infant diet and they can be contaminated with Solanaceae and other plants containing tropane alkaloids. This study was focused on the optimisation of an extraction procedure based on a solid-liquid method and an online SPE system, directly coupled to different mass spectrometry analysers as Orbitrap and triple quadrupole (QqQ), removing the chromatographi ...
DOI:
10.1016/j.foodchem.2018.09.137

12. Ultrasensitive detection of volatile aldehydes with chemi-ionization-coupled time-of-flight mass spectrometry

Author:
Yang, Bo; Xu, Ce; Shu, Jinian; Li, Zhen; Zhang, Haixu; Ma, Pengkun
Source:
Talanta 2019 v.194 pp. 888-894
ISSN:
0039-9140
Subject:
mass spectrometry,   etc   ; benzaldehyde; detection limit; humidity; ionization; ions; methylene chloride;     Show all 7 Subjects
Abstract:
... The chemi-ionization reaction is a high-efficiency pathway to produce molecular ions in plasma, however, it has rarely been applied in mass spectrometry to directly produce analyte ions. In this study, a novel chemi-ionization technique for mass spectrometry was applied for the direct and ultrasensitive detection of gaseous aldehydes. The ionization technique was enacted by a recently observed che ...
DOI:
10.1016/j.talanta.2018.11.004

13. Challenges, progress and promises of metabolite annotation for LC–MS-based metabolomics

Author:
Chaleckis, Romanas; Meister, Isabel; Zhang, Pei; Wheelock, Craig E
Source:
Current opinion in biotechnology 2019 v.55 pp. 44-50
ISSN:
0958-1669
Subject:
mass spectrometry,   etc   ; automation; liquid chromatography; metabolites; metabolome; metabolomics;     Show all 6 Subjects
Abstract:
... Accurate annotation is vital for data interpretation; however, metabolite identification is a major bottleneck in untargeted metabolomics. Although community guidelines for metabolite identification were published over a decade ago, adaptation of the recommended standards has been limited. The complexity of LC–MS data due to combinations of various chromatographic and mass spectrometric acquisitio ...
DOI:
10.1016/j.copbio.2018.07.010

14. Reagent‐free and pH‐independent degradation of N‐nitrosamines using electrons generated via corona discharge at ambient pressure

Author:
Zhuang, Meihui; Li, Hongbao; Jiang, Jun; Huang, Guangming
Source:
Journal of mass spectrometry 2019 v.54 no.2 pp. 141-147
ISSN:
1076-5174
Subject:
mass spectrometry,   etc   ; ambient pressure; electrons; heterolytic cleavage; nitrosamines; secondary amines;     Show all 6 Subjects
Abstract:
... Traditional degradation methods for N‐nitrosamines are either confined with acid solution or required for additional chemical reagents to guarantee high reaction efficiency. Herein, we demonstrate a facile and effective way for reagent‐free and pH‐independent degradation of N‐nitrosamines, which was induced by free electrons generated via corona discharge at ambient pressure. The highly reactive f ...
DOI:
10.1002/jms.4318

15. Using prepared mixtures of ToxCast chemicals to evaluate non-targeted analysis (NTA) method performance

Author:
Sobus, Jon R.; Grossman, Jarod N.; Chao, Alex; Singh, Randolph; Williams, Antony J.; Grulke, Christopher M.; Richard, Ann M.; Newton, Seth R.; McEachran, Andrew D.; Ulrich, Elin M.
Source:
Analytical and bioanalytical chemistry 2019 v.411 no.4 pp. 835-851
ISSN:
1618-2642
Subject:
mass spectrometry,   etc   ; isomers; quality control; reversed-phase liquid chromatography;     Show all 4 Subjects
Abstract:
... Non-targeted analysis (NTA) methods are increasingly used to discover contaminants of emerging concern (CECs), but the extent to which these methods can support exposure and health studies remains to be determined. EPA’s Non-Targeted Analysis Collaborative Trial (ENTACT) was launched in 2016 to address this need. As part of ENTACT, 1269 unique substances from EPA’s ToxCast library were combined to ...
DOI:
10.1007/s00216-018-1526-4

16. Single-Cell Screening of Tamoxifen Abundance and Effect Using Mass Spectrometry and Raman-Spectroscopy

Author:
Ali, Ahmed; Abouleila, Yasmine; Shimizu, Yoshihiro; Hiyama, Eiso; Watanabe, Tomonobu M.; Yanagida, Toshio; Germond, Arno
Source:
Analytical chemistry 2019 v.91 no.4 pp. 2710-2718
ISSN:
1520-6882
Subject:
mass spectrometry,   etc   ; Raman spectroscopy; metabolites; monitoring; pharmacokinetics; screening; tamoxifen;     Show all 7 Subjects
Abstract:
... Monitoring drug uptake, its metabolism, and response on the single-cell level is invaluable for sustaining drug discovery efforts. In this study, we show the possibility of accessing the information about the aforementioned processes at the single-cell level by monitoring the anticancer drug tamoxifen using live single-cell mass spectrometry (LSC–MS) and Raman spectroscopy. First, we explored whet ...
DOI:
10.1021/acs.analchem.8b04393

17. Determination of 18 antibiotics in urine using LC-QqQ-MS/MS

Author:
Huang, Wenjie; Qiu, Qiongju; Chen, Mengyu; Shi, Jingfang; Huang, Xiaodan; Kong, Qian; Long, Danfeng; Chen, Zhuang; Yan, Shijuan
Source:
Journal of chromatography 2019 v.1105 pp. 176-183
ISSN:
1570-0232
Subject:
tandem mass spectrometry,   etc   ; antibiotics; liquid chromatography; macrolides; pharmacokinetics; urine;     Show all 6 Subjects
Abstract:
... A determination method to identify and quantify 18 multi-class antibiotics in urine was developed using liquid chromatography triple quadrupole tandem mass spectrometry (LC-QqQ-MS/MS). Targeted antibiotics were extracted using preliminary dilution followed by d-SPE extraction. Specificity and selectivity, linearity, LOD and LOQ, accuracy, and precision were validated. LOQ of the majority of target ...
DOI:
10.1016/j.jchromb.2018.12.019

18. Rapid evaluation of different perovskite absorber layers through the application of depth profile analysis using glow discharge – Time of flight mass spectrometry

Author:
Fernandez, Beatriz; Lobo, Lara; Tyagi, Priyanka; Stoichkov, Vasil; Kettle, Jeff; Pereiro, Rosario
Source:
Talanta 2019 v.192 pp. 317-324
ISSN:
0039-9140
Subject:
mass spectrometry,   etc   ; dimethyl sulfoxide; dimethylformamide; glass; oxygen; rapid methods; solvents;     Show all 7 Subjects
Abstract:
... Depth profile analysis of perovskite absorber layers deposited onto glass substrates is investigated by radiofrequency pulsed glow discharge - time of flight mass spectrometry (rf-PGD-ToFMS). Elemental depth profiles obtained for perovskite films fabricated using a double-step deposition route with different precursors (methylammonium iodide and PbI2, PbCl2 or PbBr2) show varying distribution of t ...
DOI:
10.1016/j.talanta.2018.09.059

19. Effective analysis of degree of polymerization of polysialic acids in mass spectrometry by combining novel sample preparation and dynamic instrument optimization methods

Author:
Wang, Chia-Chen; Wang, Yi-Sheng
Source:
Carbohydrate research 2019 v.471 pp. 78-84
ISSN:
0008-6215
Subject:
mass spectrometry,   etc   ; carbohydrates; ions; polymerization; spectral analysis; system optimization;     Show all 6 Subjects
Abstract:
... This work demonstrates a mass spectrometry technique to improve data reliability when analyzing degree of polymerization (DP) of high-mass polysialic acids (PSAs). Matrix-assisted laser-desorption/ionization (MALDI) time-of-flight mass spectrometry is the technique of choice for analyzing large molecules due to its wide mass working range; however, the observed DP of PSAs using such an instrument ...
DOI:
10.1016/j.carres.2018.11.009

20. What are the current analytical approaches for sediment analysis related to the study of diagenesis? Highlights from 2010 to 2018

Author:
Kuznetsova, O.V.; Sevastyanov, V.S.; Timerbaev, A.R.
Source:
Talanta 2019 v.191 pp. 435-442
ISSN:
0039-9140
Subject:
mass spectrometry,   etc   ; biomarkers; chemical species; diagenesis; organic matter; sediments;     Show all 6 Subjects
Abstract:
... This review is aimed at critical analysis of current and emerging capabilities of analytical methods as employed for sediment analysis. An emphasis is given to the most reliable experimental strategies used to acquiring analytical information that is relevant to study the diagenetic processes affecting the composition of sediments. Advanced analytical methodology in use basically rely on the appli ...
DOI:
10.1016/j.talanta.2018.08.080