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1. Development of a practical online supercritical fluid extraction–supercritical fluid chromatography/mass spectrometry system with an integrated split-flow method

Author:
Sakai, Miho; Hayakawa, Yoshihiro; Funada, Yasuhiro; Ando, Takashi; Fukusaki, Eiichiro; Bamba, Takeshi
Source:
Journal of chromatography 2019 v.1592 pp. 161-172
ISSN:
0021-9673
Subject:
mass spectrometry,   etc   ; chromatography; hydrophilicity;     Show all 3 Subjects
Abstract:
... Herein, we describe a practical online supercritical fluid extraction-supercritical fluid chromatography/mass spectrometry (SFE-SFC/MS) system with an integrated split-flow method and a pre-column trap method that is well suited for the continuous extraction and separation of a wide range of compounds, including hydrophilic ones. Although an SFE-SFC system with a splitting method is already commer ...
DOI:
10.1016/j.chroma.2019.01.044

2. New frontiers in lipidomics analyses using structurally selective ion mobility-mass spectrometry

Author:
Harris, Rachel A.; Leaptrot, Katrina L.; May, Jody C.; McLean, John A.
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
mass spectrometry,   etc   ; lipids; ozonolysis;     Show all 3 Subjects
Abstract:
... The growth of lipidomics and the high isomeric complexity of the lipidome has revealed a need for analytical techniques capable of structurally characterizing lipids with a high degree of specificity. Lipids are morphologically diverse molecules that can exist as any one of a large number of isomeric species, and as such are often indistinguishable by mass spectrometry without a complementary sepa ...
DOI:
10.1016/j.trac.2019.03.031

3. Differential Ion Mobility–Mass Spectrometry for Detailed Analysis of the Proteome

Author:
Winter, Daniel L.; Wilkins, Marc R.; Donald, William A.
Source:
Trends in biotechnology 2019 v.37 no.2 pp. 198-213
ISSN:
0167-7799
Subject:
mass spectrometry,   etc   ; proteins; proteome; proteomics;     Show all 4 Subjects
Abstract:
... The field of proteomics is increasingly concerned with the diversity and functional relevance of protein modifications. Differential ion mobility spectrometry (DMS) is emerging as a tool to detect and quantify additional peptide and protein species that are difficult to analyse with conventional instrumental methods. In this review, recent advances in DMS are discussed, with a focus on the differe ...
DOI:
10.1016/j.tibtech.2018.07.018

4. Identification and quantification of synthetic cannabinoids in ‘spice-like’ herbal mixtures: Update of the German situation in summer 2018

Author:
Ernst, Ludger; Langer, Nico; Bockelmann, Aileen; Salkhordeh, Elaheh; Beuerle, Till
Source:
Forensic science international 2019 v.294 pp. 96-102
ISSN:
0379-0738
Subject:
electrospray ionization mass spectrometry; gas chromatography-mass spectrometry; tandem mass spectrometry,   etc   ; Internet; active ingredients; cannabinoids; nuclear magnetic resonance spectroscopy; summer;     Show all 8 Subjects
Abstract:
... In June 2018, 15 ‘Spice-like’ herbal products from German language internet shops were analyzed. In total, three different synthetic cannabinoids (SCs) were identified by gas chromatography–mass spectrometry (GC–MS). Two of the active ingredients were identified as the recently described 5F-ADB and Cumyl-PeGaClone. The third compound was identified as the so far unknown SC 5F-Cumyl-PeGaClone. 5F-C ...
DOI:
10.1016/j.forsciint.2018.11.001

5. MALDI-MS for polymer characterization – Recent developments and future prospects

Author:
Drzeżdżon, Joanna; Jacewicz, Dagmara; Sielicka, Alicja; Chmurzyński, Lech
Source:
Trends in analytical chemistry 2019 v.115 pp. 121-128
ISSN:
0165-9936
Subject:
mass spectrometry,   etc   ; desorption; molecular weight; polymerization; polymers;     Show all 5 Subjects
Abstract:
... The development of new polymerization methods and, consequently, the generation of new polymeric materials, is associated with the development of methods for testing the properties of these materials.The matrix assisted laser desorption and ionization - mass spectrometry method (MALDI-MS) is the technique used to study various polymers. The most important advantages of this method include the abil ...
DOI:
10.1016/j.trac.2019.04.004

6. Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening

Author:
Christner, Martin; Frickmann, Hagen; Klupp, Eva; Rohde, Holger; Kono, Maya; Tannich, Egbert; Poppert, Sven
Source:
Journal of microbiological methods 2019 v.160 pp. 104-106
ISSN:
0167-7012
Subject:
mass spectrometry,   etc   ; malaria; rapid methods; screening;     Show all 4 Subjects
Abstract:
... Laser desorption-time of flight (LD-TOF) mass spectrometry-based detection of hemozoin was assessed for its performance characteristics as a rapid screening test for malaria. In spite of good specificity of >95%, poor sensitivity of 80.2% for microscopically positive samples makes the easy-to-apply and rapid approach unsuitable for the routine diagnostic setting. ...
DOI:
10.1016/j.mimet.2019.04.002

7. Rapid extraction, discrimination and quantification of thermally unstable isomeric acteoside and isoacteoside in natural products by online extraction-quadrupole time-of-flight tandem mass spectrometry

Author:
Tong, Chaoying; Xu, Jinju; Fu, Qiachi; Long, Ruiqing; Peng, Sheng; Shi, Shuyun
Source:
Analytical methods 2019 v.11 no.16 pp. 2148-2154
ISSN:
1759-9679
Subject:
tandem mass spectrometry,   etc   ; Clerodendrum bungei; glycosides; isomers;     Show all 4 Subjects
Abstract:
... Rapid extraction, discrimination and quantification of isomers, especially for thermally unstable isomers, in complex natural products by direct MS are of great challenge due to the time-consuming sample pretreatment procedures, thermal instability, and identical mass behaviors. This work developed an online extraction-quadrupole time-of-flight tandem MS (OLE-QTOF-MS/MS) system for quantification ...
DOI:
10.1039/c8ay02584c

8. Core Size Conversion of Au₃₂₉(SCH₂CH₂Ph)₈₄ to Au₂₇₉(SPh-tBu)₈₄ Nanomolecules

Author:
Eswaramoorthy, Senthil Kumar; Sakthivel, Naga Arjun; Dass, Amala
Source:
Journal of physical chemistry 2019 v.123 no.14 pp. 9634-9639
ISSN:
1932-7455
Subject:
mass spectrometry,   etc   ; gold; ligands; physical chemistry;     Show all 4 Subjects
Abstract:
... We report the core size conversion of Au₃₂₉(SCH₂CH₂Ph)₈₄ to Au₂₇₉(SPh-tBu)₈₄ plasmonic nanomolecules. The mass spectrometric studies have revealed an unprecedented reaction pathway for the Au₃₂₉ to Au₂₇₉ core size conversion reaction via three steps. First, ligand exchange with 4-tert-butylbenzenethiolate occurs, followed by simultaneous progression of ligand exchange and core-size conversion with ...
DOI:
10.1021/acs.jpcc.9b01953

9. Challenges in the identification process of phenidate analogues in LC‐ESI‐MS/MS analysis: Information enhancement by derivatization with isobutyl chloroformate

Author:
Shamai Yamin, Tamar; Prihed, Hagit; Weissberg, Avi
Source:
Journal of mass spectrometry 2019 v.54 no.3 pp. 266-273
ISSN:
1076-5174
Subject:
tandem mass spectrometry,   etc   ; derivatization; liquid chromatography;     Show all 3 Subjects
Abstract:
... A new analytical technique for the structural elucidation of four representative phenidate analogues possessing a secondary amine residue, which leads to a major/single amine‐representative fragment/product ion at m/z 84 both in their GC‐EI‐MS and LC‐ESI‐MS/MS spectra, making their identification ambiguous, was developed. The method is based on “in vial” chemical derivatization with isobutyl chlor ...
DOI:
10.1002/jms.4327

10. Intellectual property—The Foundation of Innovation: A scientist's guide to intellectual property

Author:
Poticha, David; Duncan, Mark W.
Source:
Journal of mass spectrometry 2019 v.54 no.3 pp. 288-300
ISSN:
1076-5174
Subject:
mass spectrometry,   etc   ; business management; income; knowledge; scientists;     Show all 5 Subjects
Abstract:
... Increasingly, the activities of the practicing scientist inextricably intersect with the business world. Science is central to the development and delivery of many goods or services, and scientific discovery can directly, or indirectly, lead to substantial revenue generation. Scientists, however, have little training in the complex issues of intellectual property (IP), and often little understandi ...
DOI:
10.1002/jms.4331

11. Recent applications of high resolution mass spectrometry for the characterization of plant natural products

Author:
Alvarez-Rivera, Gerardo; Ballesteros-Vivas, Diego; Parada-Alfonso, Fabian; Ibañez, Elena; Cifuentes, Alejandro
Source:
Trends in analytical chemistry 2019 v.112 pp. 87-101
ISSN:
0165-9936
Subject:
tandem mass spectrometry,   etc   ; computer software; secondary metabolites;     Show all 3 Subjects
Abstract:
... Recently, the high analytical power provided by the new HRMS instruments (working in the MS or MS/MS mode, stand alone or hyphenated with separation techniques) is making more feasible the characterization of plant secondary metabolites. In this regard, HRMS-based techniques are becoming the technique of choice, since they are capable of answering many questions regarding the analytical characteri ...
DOI:
10.1016/j.trac.2019.01.002

12. Development and comparative analysis of yeast protein extraction protocols for mass spectrometry

Author:
Almeida, Lauana Fogaça de; Moraes, Leonardo Nazário de; Santos, Lucilene Delazari dos; Valente, Guilherme Targino
Source:
Analytical biochemistry 2019 v.567 pp. 90-95
ISSN:
0003-2697
Subject:
mass spectrometry,   etc   ; proteinase inhibitors; proteins; yeasts;     Show all 4 Subjects
Abstract:
... Mass spectrometry is the most used method for protein identification and quantification. Here we developed four protein extraction protocols precisely for mass spectrometry, and we compared with other ones already published. The best protocol developed by us consists on a simple extraction solution, a heat-shock step, and does not use protease inhibitor; moreover, it is the most efficient and unif ...
DOI:
10.1016/j.ab.2018.10.028

13. Development of a strategy for the quantification of food allergens in several food products by mass spectrometry in a routine laboratory

Author:
Planque, M.; Arnould, T.; Delahaut, P.; Renard, P.; Dieu, M.; Gillard, N.
Source:
Food chemistry 2019 v.274 pp. 35-45
ISSN:
0308-8146
Subject:
mass spectrometry,   etc   ; allergens; eggs; foods; milk; peanuts;     Show all 6 Subjects
Abstract:
... Worldwide, mass spectrometry is widely used to detect and quantify food allergens, especially in complex and processed food products. Yet, the absence of a regulatory framework for the developed methods has led to a lack of harmonization between laboratories. In this study, ten allergens were analyzed in eight food products by UHPLC–MS/MS, in order to establish criteria for the retention time, var ...
DOI:
10.1016/j.foodchem.2018.08.095

14. Mass Difference Maps and Their Application for the Recalibration of Mass Spectrometric Data in Nontargeted Metabolomics

Author:
Smirnov, Kirill S.; Forcisi, Sara; Moritz, Franco; Lucio, Marianna; Schmitt-Kopplin, Philippe
Source:
Analytical chemistry 2019 v.91 no.5 pp. 3350-3358
ISSN:
1520-6882
Subject:
mass spectrometry,   etc   ; algorithms; blood plasma; calibration; metabolomics;     Show all 5 Subjects
Abstract:
... Modern high-resolution mass spectrometry provides the great potential to analyze exact masses of thousands of molecules in one run. In addition, the high instrumental mass accuracy allows for high-precision formula assignments narrowing down tremendously the chemical space of unknown compounds. The adequate values for a mass accuracy are normally achieved by a proper calibration procedure that usu ...
DOI:
10.1021/acs.analchem.8b04555

15. Retraction Note to: Analysis of loxoprofen in tablets, patches, and equine urine as tert-butyldimethylsilyl derivative by gas chromatography-mass spectrometry

Author:
Kim, Youngbae; Seo, Chan; Oh, Suin; Kwak, Juhwan; Jung, Sumin; Sin, Eunsu; Kim, Hyunbin; Ji, Moongi; Lee, Hyeon-Seong; Park, Hyung-Jin; Lee, Gwang; Yu, Jundong; Kim, Minsoo; Lee, Wonjae; Paik, Man-Jeong
Source:
Archives of pharmacal research 2019 v.42 no.2 pp. 191
ISSN:
0253-6269
Subject:
gas chromatography-mass spectrometry,   etc   ; horses; urine;     Show all 3 Subjects
Abstract:
... The authors have retracted this article [1] because after publication they became aware that the equine urine samples analysed for loxoprofen in this study were in fact equine plasma samples. Therefore the results and conclusions of this article cannot be relied upon. All authors agree to this retraction. ...
DOI:
10.1007/s12272-019-01109-0

16. Characterization and Optimization of Multiplexed Quantitative Analyses Using High-Field Asymmetric-Waveform Ion Mobility Mass Spectrometry

Author:
Schweppe, Devin K.; Prasad, Satendra; Belford, Michael W.; Navarrete-Perea, José; Bailey, Derek J.; Huguet, Romain; Jedrychowski, Mark P.; Rad, Ramin; McAlister, Graeme; Abbatiello, Susan E.; Woulters, Eloy R.; Zabrouskov, Vlad; Dunyach, Jean-Jacques; Paulo, João A.; Gygi, Steven P.
Source:
Analytical chemistry 2019 v.91 no.6 pp. 4010-4016
ISSN:
1520-6882
Subject:
mass spectrometry,   etc   ; ions; peptides; proteomics; quantitative analysis;     Show all 5 Subjects
Abstract:
... Multiplexed, isobaric tagging methods are powerful techniques to increase throughput, precision, and accuracy in quantitative proteomics. The dynamic range and accuracy of quantitation, however, can be limited by coisolation of tag-containing peptides that release reporter ions and conflate quantitative measurements across precursors. Methods to alleviate these effects often lead to the loss of pr ...
DOI:
10.1021/acs.analchem.8b05399

17. Analysis of emerging per- and polyfluoroalkyl substances: Progress and current issues

Author:
Pan, Yitao; Wang, Jinghua; Yeung, Leo W.Y.; Wei, Si; Dai, Jiayin
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
mass spectrometry,   etc   ; gas chromatography; perfluorocarbons; toxicity;     Show all 4 Subjects
Abstract:
... The increasingly stringent restrictions on legacy per- and polyfluoroalkyl substances (PFASs) have led to the compensatory use of new fluorinated replacements. These new compounds, hereafter referred to as emerging PFASs, continue to be discovered and are now showing ubiquity in abiotic and biotic environments. Thus, there is an urgent need for robust, yet sensitive analytical methods to determine ...
DOI:
10.1016/j.trac.2019.04.013

18. Trends in trapped ion mobility – Mass spectrometry instrumentation

Author:
Ridgeway, Mark E.; Bleiholder, Christian; Mann, Matthias; Park, Melvin A.
Source:
Trends in analytical chemistry 2019
ISSN:
0165-9936
Subject:
mass spectrometry,   etc   ; instrumentation; isomers; proteomics; prototypes;     Show all 5 Subjects
Abstract:
... Trapped Ion Mobility Spectrometry (TIMS) is a recently developed form of ion mobility spectrometry (IMS) which is flexible in its operation and readily hybridized with mass spectrometry (MS). Prototype TIMS-MS instruments are applicable to a wide range of analytical problems including separation of isobars and isomers, the study of analyte conformation and unfolding, general separation of complex ...
DOI:
10.1016/j.trac.2019.03.030

19. Approaching Standardless Quantitative Elemental Analysis of Solids: Microsecond Pulsed Glow Discharge and Buffer-Gas-Assisted Laser Ionization Time-of-Flight Mass Spectrometry

Author:
Hang, Le; Xu, Zhouyi; Yin, Zhibin; Hang, Wei
Source:
Analytical chemistry 2018 v.90 no.22 pp. 13222-13228
ISSN:
1520-6882
Subject:
mass spectrometry,   etc   ; ionization; temperature;     Show all 3 Subjects
Abstract:
... Among various ionization sources for mass spectrometry, microsecond pulsed glow discharge (MP-GD) and buffer-gas-assisted laser ionization (BGA-LI) sources have the potential for direct quantitative elemental analysis of solids without the requirement of standard reference materials. The analytical potential of these two ionization sources has been evaluated by coupling them to orthogonal time-of- ...
DOI:
10.1021/acs.analchem.8b03398

20. Nonlinear effects induced in the normalized ion density in a linear trap system for a large ion cloud

Author:
Pedrosa‐Rodriguez, Laura; Outerelo, D.A.; Diaz‐Otero, Francisco J.
Source:
Journal of mass spectrometry 2018 v.53 no.10 pp. 927-933
ISSN:
1076-5174
Subject:
mass spectrometry,   etc   ; models; temperature;     Show all 3 Subjects
Abstract:
... In this work, we design, by means of a non‐neutral plasma method, a linear trapping model for large ion clouds, which will become the core of an atomic clock. We first obtain the geometry and electromagnetic characteristics of the ion trap. We then perform a systematic analysis describing the main parameters of the ion cloud such as size, secular frequency, and ion number per unit length of temper ...
DOI:
10.1002/jms.4250