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1. Antifungal activity, mycotoxin inhibitory efficacy, and mode of action of hop essential oil nanoemulsion against Fusarium graminearum

Author:
Haiyang Jiang; Shaobin Zhong; Paul Schwarz; Bingcan Chen; Jiajia Rao
Source:
Food chemistry 2023 v.400 pp. 134016
ISSN:
0308-8146
Subject:
mechanism of action,   etc   ; Fusarium graminearum; antifungal properties; cell membranes; chitin; deoxynivalenol; essential oils; food chemistry; fungi; lipids; mycelium; nanoemulsions; oils; pathogens; polysorbates; rice; spore germination;     Show all 17 Subjects
Abstract:
... This work aims to investigate antifungal, mycotoxin inhibitory efficacy of the hop essential oil (HEO) nanoemulsion and their mode of action (MOA) against Fusarium graminearum isolate, a fungal pathogen causing Fusarium Head Blight (FHB) in cereal crops. The HEO, primarily consisting of terpenes and terpenoids, was encapsulated in nanoemulsion droplets. Physically stable HEO-in-water nanoemulsion ...
DOI:
10.1016/j.foodchem.2022.134016

2. Effect of sulfamethazine on the horizontal transfer of plasmid-mediated antibiotic resistance genes and its mechanism of action

Author:
Xiaojing Yan; Wenwen Liu; Shengfang Wen; Lanjun Wang; Lusheng Zhu; Jun Wang; Young Mo Kim; Jinhua Wang
Source:
Journal of environmental sciences (China) 2023 v.127 pp. 399-409
ISSN:
1001-0742
Subject:
mechanism of action,   etc   ; Escherichia coli; antibacterial properties; antibiotic resistance; cell membranes; gene expression; horizontal gene transfer; outer membrane proteins; oxidative stress; permeability; plasmids; pollutants; sulfamethazine; China;     Show all 14 Subjects
Abstract:
... As a new type of environmental pollutant, antibiotic resistance genes (ARGs) pose a huge challenge to global health. Horizontal gene transfer (HGT) represents an important route for the spread of ARGs. The widespread use of sulfamethazine (SM2) as a broad-spectrum bacteriostatic agent leads to high residual levels in the environment, thereby increasing the spread of ARGs. Therefore, we chose to st ...
DOI:
10.1016/j.jes.2022.06.014

3. Unraveling the mechanism of the synergistic antimicrobial effect of cineole and carvacrol on Escherichia coli O157:H7 inhibition and its application on fresh-cut cucumbers

Author:
Keren Agyekumwaa Addo; Hui Li; Yigang Yu; Xinglong Xiao
Source:
Food control 2023 v.144 pp. 109339
ISSN:
0956-7135
Subject:
mechanism of action,   etc   ; DNA; Escherichia coli O157; Shiga toxin; antimicrobial properties; bacteria; biofilm; carvacrol; cineole; exopolysaccharides; flagellum; food safety; fresh produce; genes; intimin; quorum sensing; sanitizers; transcription (genetics); virulence;     Show all 19 Subjects
Abstract:
... The objective of this study was to evaluate the mechanism of the synergistic antimicrobial effect of cineole (CN) and carvacrol (CR) on E. coli and its application on fresh-cut cucumbers. Herein, the CN/CR synergy could effectively inhibit E. coli by destroying its bacterial cell structure and causing the leakage of intracellular organic matters. For the first time, CN/CR synergy interaction on E. ...
DOI:
10.1016/j.foodcont.2022.109339

4. A review on the traditional uses, phytochemistry, and pharmacology of the genus Veronicastrum (Plantaginaceae)

Author:
Elizabeth Syowai Mutinda; Elijah Mbandi Mkala; Jing Ren; Festus Kimutai; Emmanuel Nyongesa Waswa; Wyclif Ochieng Odago; Consolata Nanjala; Moses Kirega Gichua; Moses Muguci Njire; Guang-Wan Hu
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115695
ISSN:
0378-8741
Subject:
mechanism of action,   etc   ; Plantaginaceae; analgesia; antimicrobial properties; antioxidants; ascites; blood stasis; cough; drugs; dysentery; edema; fever; flavonoids; flora; headache; immunosuppression; iridoids; liver; nephritis; pharmacology; phytosterols; rheumatoid arthritis; traditional medicine; China;     Show all 24 Subjects
Abstract:
... Veronicastrum Heist. ex Fabr. (Plantaginaceae) is a multifunctional plant in China and other parts of the continent. It has traditionally been used in the treatment of ascites, edema, blood stasis, pain relief, chronic nephritis injury, fever, cough, headache, arthritis, dysentery, rheumatism, pleural effusion, liver damage, and other disorders. Although research has confirmed that the genus Veron ...
DOI:
10.1016/j.jep.2022.115695

5. Combining LC-MS/MS profiles with network pharmacology to predict molecular mechanisms of the hyperlipidemic activity of Lagenaria siceraria stand

Author:
Subhadip Banerjee; Amrendra Tiwari; Amit Kar; Joydeb Chanda; Sayan Biswas; Gudrun Ulrich-Merzenich; Pulok K. Mukherjee
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115633
ISSN:
0378-8741
Subject:
mechanism of action,   etc   ; Ayurvedic medicine; Lagenaria siceraria; albino; alcohols; animals; atorvastatin; bioinformatics; computer simulation; ferulic acid; food plants; hesperidin; high fat diet; hyperlipidemia; hypertension; insulin; lipids; metabolites; obesity; p-coumaric acid; pharmacology;     Show all 21 Subjects
Abstract:
... Lagenaria siceraria Stand. (Family: Cucurbitaceae), popularly known as bottle gourd, is traditionally used in Ayurvedic medicine as a food plant, especially in hypertension and obesity. Investigations were undertaken to assign novel lead combinations from this common food plant to multi-molecular modes of actions in the complex disease networks of obesity and hypertension. LC–MS/MS based metabolit ...
DOI:
10.1016/j.jep.2022.115633

6. Anadenanthera colubrina (Vell) Brenan: Ethnobotanical, phytochemical, pharmacological and toxicological aspects

Author:
Merline Delices; Jessica de Araujo Isaias Muller; Karuppusamy Arunachalam; Domingos Tabajara de Oliveira Martins
Source:
Journal of ethnopharmacology 2023 v.300 no. pp. 115745
ISSN:
0378-8741
Subject:
mechanism of action,   etc   ; Anadenanthera colubrina; National Center for Biotechnology Information; antioxidants; antiviral properties; bark; databases; environmental impact; ethnobotany; flavonoids; herbal medicines; indigenous species; insecticides; therapeutics; toxicity; toxicology; traditional medicine; trees; triterpenoids; South America;     Show all 20 Subjects
Abstract:
... Anadenanthera colubrina (Vell.) Brenan is an endemic tree to South America and different parts of it are used by the population for the treatment of various diseases, as well as in indigenous rituals. This species has high pharmacological potential but may present toxic potential due to the presence of psychotropic compounds. To review published studies with the species A. colubrina regarding ethn ...
DOI:
10.1016/j.jep.2022.115745

7. Integrated serum pharmacochemistry and network pharmacology analyses reveal the bioactive metabolites and potential functional mechanism of ground cherry (Physalis pruinosa L.) in treatment of type 2 diabetes mellitus in rats

Author:
Asmaa Mahana; Hala M. Hammoda; Asmaa A. Khalifa; Samar S. Elblehi; Fathallah M. Harraz; Eman Shawky
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115750
ISSN:
0378-8741
Subject:
mechanism of action,   etc   ; Physalis pruinosa; atherosclerosis; blood serum; calyx; cherries; gene ontology; genome; glucose; glycemic effect; high fat diet; histopathology; immunoblotting; insulin; lipid metabolism; lipids; metabolites; models; noninsulin-dependent diabetes mellitus; pharmacology; quercetin; rats; streptozotocin; traditional medicine;     Show all 24 Subjects
Abstract:
... Different Physalis plants have been widely employed in traditional medicine for management of diabetes mellitus. Previous studies with respect to the in vivo antidiabetic activity of Physalis plants illustrated that they improved glucose and lipid metabolism in streptozotocin (STZ) -induced diabetic rats yet the mechanism of action of bioactive constituents of the different organs of Physalis plan ...
DOI:
10.1016/j.jep.2022.115750

8. Force: A messenger of axon outgrowth

Author:
Vittoria Raffa
Source:
Seminars in cell & developmental biology 2022 pp. -
ISSN:
1084-9521
Subject:
mechanism of action,   etc   ; axons; cytoskeleton;     Show all 3 Subjects
Abstract:
... The axon is a sophisticated macromolecular machine composed of interrelated parts that transmit signals like spur gears transfer motion between parallel shafts. The growth cone is a fine sensor that integrates mechanical and chemical cues and transduces these signals through the generation of a traction force that pushes the tip and pulls the axon shaft forward. The axon shaft, in turn, senses thi ...
DOI:
10.1016/j.semcdb.2022.07.004

9. Lytic polysaccharide monooxygenases as powerful tools in enzymatically assisted preparation of nano-scaled cellulose from lignocellulose: A review

Author:
Anthi Karnaouri; Koar Chorozian; Dimitrios Zouraris; Antonis Karantonis; Evangelos Topakas; Ulrika Rova; Paul Christakopoulos
Source:
Bioresource technology 2022 v.345 pp. 126491
ISSN:
0960-8524
Subject:
mechanism of action,   etc   ; biomass; cellulose; lignocellulose;     Show all 4 Subjects
Abstract:
... Nanocellulose, either in the form of fibers or crystals, constitutes a renewable, biobased, biocompatible material with advantageous mechanical properties that can be isolated from lignocellulosic biomass. Enzyme-assisted isolation of nanocellulose is an attractive, environmentally friendly approach that leads to products of higher quality compared to their chemically prepared counterparts. Lytic ...
DOI:
10.1016/j.biortech.2021.126491

10. Pulsatilla decoction improves DSS-induced colitis via modulation of fecal-bacteria-related short-chain fatty acids and intestinal barrier integrity

Author:
Chun Niu; Xiao-li Hu; Zi-wen Yuan; Ying Xiao; Peng Ji; Yan-ming Wei; Yong-li Hua
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115741
ISSN:
0378-8741
Subject:
mechanism of action,   etc   ; Bacteroides; Clostridium; Escherichia; Lachnospiraceae; Pulsatilla; acetates; blood serum; body weight; dextran; enzyme-linked immunosorbent assay; gas chromatography-mass spectrometry; genes; homeostasis; interleukin-10; interleukin-17; intestinal microorganisms; intestines; males; metabolism; models; occludins; propionic acid; short chain fatty acids; sodium sulfate; therapeutics; tight junctions; traditional medicine; tumor necrosis factor-alpha; ulcerative colitis;     Show all 30 Subjects
Abstract:
... Pulsatilla decoction (PD), is an herbal formula commonly used for the treatment of ulcerative colitis (UC) in clinical practice, but the mechanism of PD alters the colitis remains elusive. To evaluate the intervention effect of PD on Dextran Sodium Sulfate (DSS)-induced UC based on gut microbiota and intestinal short-chain fatty acid (SCFAs) metabolism, and to investigate the mechanism of action o ...
DOI:
10.1016/j.jep.2022.115741

11. Barite Removal Using Macropa: Simulation and Solubility Investigations

Author:
Amjed Hassan; Fadhil S. Kamounah; Michael Pittelkow; Theis Solling; Mohamed Mahmoud
Source:
Energy & fuels 2022 v.36 no.16 pp. 9101-9110
ISSN:
1520-5029
Subject:
mechanism of action,   etc   ; barite; energy; pH; solubility;     Show all 5 Subjects
Abstract:
... We describe an in-depth study of the performance of the macrocyclic descaling agent ‘macropa’ for barite (BaSO₄) removal. Macropa outcompetes known chelating agents such as DTPA, HEDTA, and EDTA at moderate pH. The solubility studies showed that macropa has a promising performance in removing the barite minerals at a pH of 8. Around 11.4 g of barite can be dissolved in 1 L of the macropa solution ...
DOI:
10.1021/acs.energyfuels.2c02038

12. Ricin toxin and its neutralizing antibodies: A review

Author:
Haotian Yu; Songyan Li; Na Xu; Wensen Liu
Source:
Toxicon 2022 v.214 pp. 47-53
ISSN:
0041-0101
Subject:
mechanism of action,   etc   ; disease control; ricin; toxins;     Show all 4 Subjects
Abstract:
... Ricin toxin (RT) belongs to the ribosome-inactivating protein (RIP) family of toxins and is considered to be a moderate threat by the US Center of Disease Control and Prevention (CDC). RT poses a great potential threat to the public, but there has been a lack of effective treatment options so far. Over the past few decades, researches on the prevention and treatment of RT poisoning have been inves ...
DOI:
10.1016/j.toxicon.2022.05.005

13. Matching chemical properties to molecular biological activities opens a new perspective on l‐ergothioneine

Author:
Jean‐Claude Yadan
Source:
FEBS letters 2022 v.596 no.10 pp. 1299-1312
ISSN:
0014-5793
Subject:
mechanism of action,   etc   ; chemical reactions; chemical structure;     Show all 3 Subjects
Abstract:
... l‐ergothioneine is a low‐molecular weight natural product, the chemical structure of which comprises oxygen‐, nitrogen‐ and sulfur‐containing functional groups. This gives l‐ergothioneine specific physicochemical properties and allows a better understanding of its chemical reactivity, which is primarily due to the 2‐thio‐imidazole group. Here, a review is provided of how different modes of chemica ...
DOI:
10.1002/1873-3468.14264

14. Non-destructive molecular FTIR spectromicroscopy for real time assessment of redox metallodrugs

Author:
Lucyano J. A. Macedo; Fernando P. Rodrigues; Ayaz Hassan; Leandro N. C. Máximo; Fabio Zobi; Roberto S. da Silva; Frank N. Crespilho
Source:
Analytical methods 2022 v.14 no.11 pp. 1094-1102
ISSN:
1759-9679
Subject:
mechanism of action,   etc   ; DNA; bioimaging; drugs; toxicity;     Show all 5 Subjects
Abstract:
... Recent emergence of FTIR spectromicroscopy (micro-FTIR) as a dynamic spectroscopy for imaging to study biological chemistry has opened new possibilities for investigating in situ drug release, redox chemistry effects on biological molecules, DNA and drug interactions, membrane dynamics, and redox reactions with proteins at the single cell level. Micro-FTIR applied to metallodrugs has been playing ...
DOI:
10.1039/d1ay01198g

15. The role of sustainability in the emergence and evolution of bioeconomy clusters: An application of a multiscalar framework

Author:
David Ayrapetyan; Nicolas Befort; Frans Hermans
Source:
Journal of cleaner production 2022 v.376 pp. 134306
ISSN:
0959-6526
Subject:
mechanism of action,   etc   ; bioeconomics; issues and policy;     Show all 3 Subjects
Abstract:
... Bioeconomy clusters, besides stimulating economic and innovative performance, are expected to promote sustainable regional development. Despite their growing popularity, there is still a lack of awareness about how these clusters contribute to sustainability. This paper aims at increasing our understanding of the processes through which bioeconomy clusters generate sustainability effects and promo ...
DOI:
10.1016/j.jclepro.2022.134306

16. Chemoproteomic profiling reveals celastrol as a potential modulator of cholesterol signaling

Author:
Yiyun Geng; Jingyuan Xu; Weichao Li; Qing Li; Chenjinxin Shen; Zhangshuang Deng; Yiqing Zhou
Source:
Chemical communications 2022 v.58 no.12 pp. 1914-1917
ISSN:
1364-548X
Subject:
mechanism of action,   etc   ; chemical communication; cholesterol; quantitative analysis;     Show all 4 Subjects
Abstract:
... We report a quantitative chemoproteomic approach that utilizes a clickable photoreactive probe for global profiling of celastrol targets, which may significantly improve the current understanding of celastrol's mode of action. ...
DOI:
10.1039/d1cc05986f

17. Structure, function and mechanistic aspects of scorpion venom peptides - A boon for the development of novel therapeutics

Author:
R. Suhas
Source:
European journal of medicinal chemistry reports 2022 v.6 pp. 100068
ISSN:
2772-4174
Subject:
mechanism of action,   etc   ; Scorpiones; peptides; scorpion venoms; therapeutics;     Show all 5 Subjects
Abstract:
... Venom of scorpions is very expensive and lethal, yet with innumerable and exciting potential as a source for the development of biotherapeutics. One of the chief components of scorpion venom is the ‘peptides’ which have shown diverse array of biological activities, promising site specificity and are also involved in the regulation of biological mechanisms. These peptides have especially gained mor ...
DOI:
10.1016/j.ejmcr.2022.100068

18. In Vitro Methodologies to Study the Role of Advanced Glycation End Products (AGEs) in Neurodegeneration

Author:
Marialena Chrysanthou; Ignacio Miro Estruch; Ivonne M. C. M. Rietjens; Harry J. Wichers; Tamara Hoppenbrouwers
Source:
Nutrients 2022 v.14 no.2 pp. -
ISSN:
2072-6643
Subject:
mechanism of action,   etc   ; amyotrophic lateral sclerosis; crosslinking; sclerosis;     Show all 4 Subjects
Abstract:
... Advanced glycation end products (AGEs) can be present in food or be endogenously produced in biological systems. Their formation has been associated with chronic neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis. The implication of AGEs in neurodegeneration is related to their ability to bind to AGE-specific receptors ...
DOI:
10.3390/nu14020363

19. Mechanism of Action of Ribosomally Synthesized and Post-Translationally Modified Peptides

Author:
Chayanid Ongpipattanakul; Emily K. Desormeaux; Adam DiCaprio; Wilfred A. van der Donk; Douglas A. Mitchell; Satish K. Nair
Source:
Chemical reviews 2022 v.122 no.18 pp. 14722-14814
ISSN:
1520-6890
Subject:
mechanism of action,   etc   ; RNA; biosynthesis; evolution; genome; peptides;     Show all 6 Subjects
Abstract:
... Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural product class that has undergone significant expansion due to the rapid growth in genome sequencing data and recognition that they are made by biosynthetic pathways that share many characteristic features. Their mode of actions cover a wide range of biological processes and include binding to membranes, recept ...
DOI:
10.1021/acs.chemrev.2c00210

20. Nanomaterials in plant systems: Smart advances related to water uptake and transport involving aquaporins

Author:
Gloria Bárzana; Pablo Garcia-Gomez; Micaela Carvajal
Source:
Plant nano biology 2022 v.1 pp. 100005
ISSN:
2773-1111
Subject:
mechanism of action,   etc   ; abiotic stress; aquaporins; water uptake;     Show all 4 Subjects
Abstract:
... The application of nanoparticles (NPs) has been shown to be a very effective technology for increasing plant yield. Their use in agriculture has been associated with the reduction of fertilization, but their effectiveness depends on the concentrations applied, physiochemical properties, and plant species. Nevertheless, one of the most common reported effects, independently on the type of NPs, is t ...
DOI:
10.1016/j.plana.2022.100005