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... This work aims to investigate antifungal, mycotoxin inhibitory efficacy of the hop essential oil (HEO) nanoemulsion and their mode of action (MOA) against Fusarium graminearum isolate, a fungal pathogen causing Fusarium Head Blight (FHB) in cereal crops. The HEO, primarily consisting of terpenes and terpenoids, was encapsulated in nanoemulsion droplets. Physically stable HEO-in-water nanoemulsion ...
... As a new type of environmental pollutant, antibiotic resistance genes (ARGs) pose a huge challenge to global health. Horizontal gene transfer (HGT) represents an important route for the spread of ARGs. The widespread use of sulfamethazine (SM2) as a broad-spectrum bacteriostatic agent leads to high residual levels in the environment, thereby increasing the spread of ARGs. Therefore, we chose to st ...
... The objective of this study was to evaluate the mechanism of the synergistic antimicrobial effect of cineole (CN) and carvacrol (CR) on E. coli and its application on fresh-cut cucumbers. Herein, the CN/CR synergy could effectively inhibit E. coli by destroying its bacterial cell structure and causing the leakage of intracellular organic matters. For the first time, CN/CR synergy interaction on E. ...
... Veronicastrum Heist. ex Fabr. (Plantaginaceae) is a multifunctional plant in China and other parts of the continent. It has traditionally been used in the treatment of ascites, edema, blood stasis, pain relief, chronic nephritis injury, fever, cough, headache, arthritis, dysentery, rheumatism, pleural effusion, liver damage, and other disorders. Although research has confirmed that the genus Veron ...
... Lagenaria siceraria Stand. (Family: Cucurbitaceae), popularly known as bottle gourd, is traditionally used in Ayurvedic medicine as a food plant, especially in hypertension and obesity. Investigations were undertaken to assign novel lead combinations from this common food plant to multi-molecular modes of actions in the complex disease networks of obesity and hypertension. LC–MS/MS based metabolit ...
mechanismofaction, etc ; Anadenanthera colubrina; National Center for Biotechnology Information; antioxidants; antiviral properties; bark; databases; environmental impact; ethnobotany; flavonoids; herbal medicines; indigenous species; insecticides; therapeutics; toxicity; toxicology; traditional medicine; trees; triterpenoids; South America; Show all 20 Subjects
Abstract:
... Anadenanthera colubrina (Vell.) Brenan is an endemic tree to South America and different parts of it are used by the population for the treatment of various diseases, as well as in indigenous rituals. This species has high pharmacological potential but may present toxic potential due to the presence of psychotropic compounds. To review published studies with the species A. colubrina regarding ethn ...
mechanismofaction, etc ; Physalis pruinosa; atherosclerosis; blood serum; calyx; cherries; gene ontology; genome; glucose; glycemic effect; high fat diet; histopathology; immunoblotting; insulin; lipid metabolism; lipids; metabolites; models; noninsulin-dependent diabetes mellitus; pharmacology; quercetin; rats; streptozotocin; traditional medicine; Show all 24 Subjects
Abstract:
... Different Physalis plants have been widely employed in traditional medicine for management of diabetes mellitus. Previous studies with respect to the in vivo antidiabetic activity of Physalis plants illustrated that they improved glucose and lipid metabolism in streptozotocin (STZ) -induced diabetic rats yet the mechanism of action of bioactive constituents of the different organs of Physalis plan ...
... The axon is a sophisticated macromolecular machine composed of interrelated parts that transmit signals like spur gears transfer motion between parallel shafts. The growth cone is a fine sensor that integrates mechanical and chemical cues and transduces these signals through the generation of a traction force that pushes the tip and pulls the axon shaft forward. The axon shaft, in turn, senses thi ...
mechanismofaction, etc ; biomass; cellulose; lignocellulose; Show all 4 Subjects
Abstract:
... Nanocellulose, either in the form of fibers or crystals, constitutes a renewable, biobased, biocompatible material with advantageous mechanical properties that can be isolated from lignocellulosic biomass. Enzyme-assisted isolation of nanocellulose is an attractive, environmentally friendly approach that leads to products of higher quality compared to their chemically prepared counterparts. Lytic ...
mechanismofaction, etc ; Bacteroides; Clostridium; Escherichia; Lachnospiraceae; Pulsatilla; acetates; blood serum; body weight; dextran; enzyme-linked immunosorbent assay; gas chromatography-mass spectrometry; genes; homeostasis; interleukin-10; interleukin-17; intestinal microorganisms; intestines; males; metabolism; models; occludins; propionic acid; short chain fatty acids; sodium sulfate; therapeutics; tight junctions; traditional medicine; tumor necrosis factor-alpha; ulcerative colitis; Show all 30 Subjects
Abstract:
... Pulsatilla decoction (PD), is an herbal formula commonly used for the treatment of ulcerative colitis (UC) in clinical practice, but the mechanism of PD alters the colitis remains elusive. To evaluate the intervention effect of PD on Dextran Sodium Sulfate (DSS)-induced UC based on gut microbiota and intestinal short-chain fatty acid (SCFAs) metabolism, and to investigate the mechanism of action o ...
mechanismofaction, etc ; barite; energy; pH; solubility; Show all 5 Subjects
Abstract:
... We describe an in-depth study of the performance of the macrocyclic descaling agent ‘macropa’ for barite (BaSO₄) removal. Macropa outcompetes known chelating agents such as DTPA, HEDTA, and EDTA at moderate pH. The solubility studies showed that macropa has a promising performance in removing the barite minerals at a pH of 8. Around 11.4 g of barite can be dissolved in 1 L of the macropa solution ...
mechanismofaction, etc ; disease control; ricin; toxins; Show all 4 Subjects
Abstract:
... Ricin toxin (RT) belongs to the ribosome-inactivating protein (RIP) family of toxins and is considered to be a moderate threat by the US Center of Disease Control and Prevention (CDC). RT poses a great potential threat to the public, but there has been a lack of effective treatment options so far. Over the past few decades, researches on the prevention and treatment of RT poisoning have been inves ...
mechanismofaction, etc ; chemical reactions; chemical structure; Show all 3 Subjects
Abstract:
... l‐ergothioneine is a low‐molecular weight natural product, the chemical structure of which comprises oxygen‐, nitrogen‐ and sulfur‐containing functional groups. This gives l‐ergothioneine specific physicochemical properties and allows a better understanding of its chemical reactivity, which is primarily due to the 2‐thio‐imidazole group. Here, a review is provided of how different modes of chemica ...
mechanismofaction, etc ; DNA; bioimaging; drugs; toxicity; Show all 5 Subjects
Abstract:
... Recent emergence of FTIR spectromicroscopy (micro-FTIR) as a dynamic spectroscopy for imaging to study biological chemistry has opened new possibilities for investigating in situ drug release, redox chemistry effects on biological molecules, DNA and drug interactions, membrane dynamics, and redox reactions with proteins at the single cell level. Micro-FTIR applied to metallodrugs has been playing ...
mechanismofaction, etc ; bioeconomics; issues and policy; Show all 3 Subjects
Abstract:
... Bioeconomy clusters, besides stimulating economic and innovative performance, are expected to promote sustainable regional development. Despite their growing popularity, there is still a lack of awareness about how these clusters contribute to sustainability. This paper aims at increasing our understanding of the processes through which bioeconomy clusters generate sustainability effects and promo ...
mechanismofaction, etc ; chemical communication; cholesterol; quantitative analysis; Show all 4 Subjects
Abstract:
... We report a quantitative chemoproteomic approach that utilizes a clickable photoreactive probe for global profiling of celastrol targets, which may significantly improve the current understanding of celastrol's mode of action. ...
mechanismofaction, etc ; Scorpiones; peptides; scorpion venoms; therapeutics; Show all 5 Subjects
Abstract:
... Venom of scorpions is very expensive and lethal, yet with innumerable and exciting potential as a source for the development of biotherapeutics. One of the chief components of scorpion venom is the ‘peptides’ which have shown diverse array of biological activities, promising site specificity and are also involved in the regulation of biological mechanisms. These peptides have especially gained mor ...
mechanismofaction, etc ; amyotrophic lateral sclerosis; crosslinking; sclerosis; Show all 4 Subjects
Abstract:
... Advanced glycation end products (AGEs) can be present in food or be endogenously produced in biological systems. Their formation has been associated with chronic neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis. The implication of AGEs in neurodegeneration is related to their ability to bind to AGE-specific receptors ...
mechanismofaction, etc ; RNA; biosynthesis; evolution; genome; peptides; Show all 6 Subjects
Abstract:
... Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural product class that has undergone significant expansion due to the rapid growth in genome sequencing data and recognition that they are made by biosynthetic pathways that share many characteristic features. Their mode of actions cover a wide range of biological processes and include binding to membranes, recept ...
mechanismofaction, etc ; abiotic stress; aquaporins; water uptake; Show all 4 Subjects
Abstract:
... The application of nanoparticles (NPs) has been shown to be a very effective technology for increasing plant yield. Their use in agriculture has been associated with the reduction of fertilization, but their effectiveness depends on the concentrations applied, physiochemical properties, and plant species. Nevertheless, one of the most common reported effects, independently on the type of NPs, is t ...