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1. Acetogenins from Annonaceae family. Their potential biological applications

Author:
Neske, Adriana; Ruiz Hidalgo, José; Cabedo, Nuria; Cortes, Diego
Source:
Phytochemistry 2020 v.174 pp. 112332
ISSN:
0031-9422
Subject:
mechanism of action,   etc   ; Annonaceae; acetogenins; bioactive properties;     Show all 4 Subjects
Abstract:
... The aim of this contribution has been to continue with the knowledge about newly isolated acetogenins from Annonaceae family for the last fifteen years. This review will report classification, extraction, isolation, elucidation of the structure, biological activities and mechanism of action of such interesting natural products. In fact, out of the 532 compounds reviewed, 115 previously non-describ ...
DOI:
10.1016/j.phytochem.2020.112332

2. Methods to generate tissue-derived constructs for regenerative medicine applications

Author:
Paulo Zambon, Joao; Atala, Anthony; Yoo, James J.
Source:
Methods 2020 v.171 pp. 3-10
ISSN:
1046-2023
Subject:
mechanism of action,   etc   ; medicine; patients; tissue engineering; tissue scaffolds;     Show all 5 Subjects
Abstract:
... The shortage of donor organs for transplantation remains a continued problem for patients with irreversible end-stage organ failure. Tissue engineering and regenerative medicine aims to develop therapies to provide viable solutions for these patients. Use of decellularized tissue scaffolds has emerged as an attractive approach to generate tissue constructs that mimic native tissue architecture and ...
DOI:
10.1016/j.ymeth.2019.09.016

3. An exploratory component analysis of emotion regulation strategies for improving emotion regulation and emotional eating

Author:
Juarascio, Adrienne S.; Parker, Megan N.; Manasse, Stephanie M.; Barney, Jennifer L.; Wyckoff, Emily P.; Dochat, Cara
Source:
Appetite 2020 v.150 pp. 104634
ISSN:
0195-6663
Subject:
mechanism of action,   etc   ; adults; clinical trials; distress; eating habits; emotions; signs and symptoms (animals and humans);     Show all 7 Subjects
Abstract:
... Emotion-focused treatments are generally efficacious for improving emotion regulation and consequently, improving clinical symptoms across numerous disorders. However, emotion-focused treatment approaches often contain numerous treatment components, limiting our ability to identify which are most efficacious. As such, the current pilot study sought to isolate three components common across a range ...
DOI:
10.1016/j.appet.2020.104634

4. Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery

Author:
Madden, Sarah K.; Itzhaki, Laura S.
Source:
Biochimica et biophysica acta 2020 v.1868 no.7 pp. 140405
ISSN:
1570-9639
Subject:
mechanism of action,   etc   ; Lewis acids; drugs; oxidative stress; protein degradation; proteins; therapeutics;     Show all 7 Subjects
Abstract:
... The proteins Keap1 and Nrf2 together act as a cytoprotective mechanism that enables cells to overcome electrophilic and oxidative stress. Research has shown that manipulating this system by modulating the Keap1-Nrf2 interaction either through inhibition at the binding interface or via the covalent modification of Keap1 could provide a powerful therapeutic strategy for a range of diseases. However, ...
DOI:
10.1016/j.bbapap.2020.140405

5. Redox Partners: Function Modulators of Bacterial P450 Enzymes

Author:
Li, Shengying; Du, Lei; Bernhardt, Rita
Source:
Trends in microbiology 2020 v.28 no.6 pp. 445-454
ISSN:
0966-842X
Subject:
mechanism of action,   etc   ; catalytic activity; cytochrome P-450; electron transfer; electrons; oxygen; oxygenases;     Show all 7 Subjects
Abstract:
... The superfamily of cytochrome P450 monooxygenases (P450s) is widespread in all kingdoms of life. Functionally versatile P450s are extensively involved in diverse anabolic and catabolic processes. P450s require electrons to be transferred by redox partners (RPs) for O₂ activation and substrate monooxygenation. Unlike monotonic eukaryotic cytochrome P450 reductases, bacterial RP systems are more div ...
DOI:
10.1016/j.tim.2020.02.012

6. An improved synthesis of hemichrysophaentin-AB fragment of chrysophaentin A

Author:
Fullenkamp, Christopher R.; Sulikowski, Gary A.
Source:
Tetrahedron letters 2020 v.61 no.20 pp. 151856
ISSN:
0040-4039
Subject:
mechanism of action,   etc   ; Gram-positive bacteria; Lewis acids; antimicrobial properties; chemical reactions; chemical structure; organic compounds;     Show all 7 Subjects
Abstract:
... Synthetic fragments of chrysophaentin A, a rare antimicrobial marine natural product, were required to support structure-activity and mechanism of action studies. Hemichrysophaentin, a synthetic fragment of chrysophaentin A showed antimicrobial activity against Gram-positive bacteria, presumably acting through the inhibition of the microbial tubulin-like protein FtsZ. Here in, we report a concise ...
DOI:
10.1016/j.tetlet.2020.151856

7. Bacterial biofilm in colorectal cancer: What is the real mechanism of action?

Author:
Mirzaei, Rasoul; Mirzaei, Hamed; Alikhani, Mohammad Yousef; Sholeh, Mohammad; Arabestani, Mohammad Reza; Saidijam, Massoud; Karampoor, Sajad; Ahmadyousefi, Yaghoub; Moghadam, Mohammad Shokri; Irajian, Gholam Reza; Hasanvand, Hamze; Yousefimashouf, Rasoul
Source:
Microbial pathogenesis 2020 v.142 pp. 104052
ISSN:
0882-4010
Subject:
mechanism of action,   etc   ; biofilm; colon; colorectal neoplasms; humans; inflammatory bowel disease; microorganisms; risk factors;     Show all 8 Subjects
Abstract:
... Human colorectal cancer is the third most common cancer around the world. Colorectal cancer has various risk factors, but current works have bolded a significant activity for the microbiota of the human colon in the development of this disease. Bacterial biofilm has been mediated to non-malignant pathologies like inflammatory bowel disease but has not been fully documented in the setting of colore ...
DOI:
10.1016/j.micpath.2020.104052

8. Polysaccharides from Marine Enteromorpha: Structure and function

Author:
Zhong, Ruting; Wan, Xuzhi; Wang, Dingyi; Zhao, Chao; Liu, Dan; Gao, Luying; Wang, Mingfu; Wu, ChangJer; Nabavid, Sayed Mohammad; Daglia, Maria; Capanoglu, Esra; Xiao, Jianbo; Cao, Hui
Source:
Trends in food science & technology 2020 v.99 pp. 11-20
ISSN:
0924-2244
Subject:
mechanism of action,   etc   ; Ulva; antibacterial properties; antioxidant activity; antioxidants; drugs; molecular weight; polysaccharides; structure-activity relationships;     Show all 9 Subjects
Abstract:
... Marine Enteromorpha polysaccharides (EPPs) have been reported to present various physiological and bioactivities based on their specific chemical structures, such as monosaccharide compositions and glycosidic linkages.However, the structure-activity relationship of Enteromorpha polysaccharides is mostly unknown. This review aims to provide a brief summary of structural, functional, and chemical ch ...
DOI:
10.1016/j.tifs.2020.02.030

9. Reproductive cycle progression arrest and modification of cell morphology (shape and biovolume) in the alga Pseudokirchneriella subcapitata exposed to metolachlor

Author:
Machado, Manuela D.; Soares, Eduardo V.
Source:
Aquatic toxicology 2020 v.222 pp. 105449
ISSN:
0166-445X
Subject:
mechanism of action,   etc   ; Selenastrum capricornutum; biochemical pathways; cell structures; chlorophyll; metolachlor; microalgae; nontarget organisms; photosynthesis; toxicity;     Show all 10 Subjects
Abstract:
... Metolachlor (MET) is an herbicide widely used and frequently found (at μg L⁻¹) in aquatic systems. This work aimed to study the modes of action of MET on the green microalga Pseudokirchneriella subcapitata. Algae exposed to 115 or 235 μg L⁻¹ MET, for 48 or 72 h, presented a reduction of metabolic activity, chlorophyll a and b content and photosynthetic efficiency. The exposure to 115 or 235 μg L⁻¹ ...
DOI:
10.1016/j.aquatox.2020.105449

10. A comparison of the practices and influential factors of pro-environmental behaviors in three Asian megacities: Bangkok, Tokyo, and Seoul

Author:
Phuphisith, Sarunnoud; Kurisu, Kiyo; Hanaki, Keisuke
Source:
Journal of cleaner production 2020 v.253 pp. 119882
ISSN:
0959-6526
Subject:
mechanism of action,   etc   ; cities; correspondence analysis; energy conservation; lifestyle; purchasing; society; transportation; wastes;     Show all 9 Subjects
Abstract:
... In order to adopt environmentally friendly modes of actions, pro-environmental behaviors (PEBs) have been promoted in many countries to improve people’s consumption patterns and lifestyles in a sustainable manner. The current practices and influential factors of people can differ by country, but related studies in the Asian region are limited. The present study aims to examine the differences in P ...
DOI:
10.1016/j.jclepro.2019.119882

11. Concentration-dependent transcriptome of zebrafish embryo for environmental chemical assessment

Author:
Wang, Pingping; Wang, Zhihao; Xia, Pu; Zhang, Xiaowei
Source:
Chemosphere 2020 v.245 pp. 125632
ISSN:
0045-6535
Subject:
mechanism of action,   etc   ; Danio rerio; adverse effects; death; embryo (animal); embryotoxicity; lethal dose 50; transcriptome;     Show all 8 Subjects
Abstract:
... Mechanistic information is essential to screen and predict the adverse effects of a large number of chemicals during early-life exposure. Concentration-dependent omics can capture the extent of perturbations of biological pathways or processes and provide information on the mechanism of toxicity. However, the application of concentration-dependent transcriptome to assess the developmental toxicity ...
DOI:
10.1016/j.chemosphere.2019.125632

12. The Effects of 17α‐Ethinylestradiol on the Heart Rate of Embryonic Japanese Medaka (Oryzias latipes)

Author:
Anderson, Jordan Christopher; Beyger, Lindsay; Guchardi, John; Holdway, Douglas Alan
Source:
Environmental toxicology and chemistry 2020 v.39 no.4 pp. 904-912
ISSN:
0730-7268
Subject:
mechanism of action,   etc   ; Oryzias latipes; cardiovascular system; estrogen receptors; estrogens; heart rate; signal transduction; toxicity; toxicology;     Show all 9 Subjects
Abstract:
... Estrogen toxicity has been an area of priority in aquatic toxicology over the last 20 yr. Currently, estrogen toxicity is primarily linked to classical estrogen signaling, the interaction of estrogen receptors alpha and beta (ERα and ERβ). Recent evidence has indicated that a rapid, nongenomic, nonclassical estrogen signaling pathway exists via the G protein–coupled estrogen receptor (GPER), which ...
DOI:
10.1002/etc.4691

13. Development of reporter gene assays to determine the bioactivity of biopharmaceuticals

Author:
Wang, Lan; Yu, Chuanfei; Wang, Junzhi
Source:
Biotechnology advances 2020 v.39 pp. 107466
ISSN:
0734-9750
Subject:
mechanism of action,   etc   ; bioactive properties; bioassays; biopharmaceuticals; biotechnology; quality control; reporter genes; screening; structure-activity relationships;     Show all 9 Subjects
Abstract:
... Complex structure and structure-function relationship of biopharmaceuticals require extensive analytical characterization and appropriate quality control of the products. Despite rapid development of sophisticated physicochemical techniques, biological activity measurement remains the critical role in inferring the high-order structure of biopharmaceuticals. Cell-based biological assays are mostly ...
DOI:
10.1016/j.biotechadv.2019.107466

14. European General Practitioners perceptions on probiotics: Results of a multinational survey

Author:
van der Geest, A.M.; Flach, J.; Claassen, E.; Sijlmans, A.W.; van de Burgwal, L.H.M.; Larsen, O.F.A.
Source:
PharmaNutrition 2020 v.11 pp. 100178
ISSN:
2213-4344
Subject:
mechanism of action,   etc   ; antibiotics; diarrhea; general practitioners; interviews; pain; probiotics; public opinion; social behavior; surveys;     Show all 10 Subjects
Abstract:
... Public opinion and consumer adoption of probiotics is influenced by the perception and recommendations of General Practitioners (GPs), but the perceptions and recommendations of European GPs currently appear to be underreported. This paper therefore relates the perceptions of European GPs towards probiotics with their recommendations. Standardized telephonic interviews were conducted with 1318 GPs ...
DOI:
10.1016/j.phanu.2020.100178

15. Fluorescent Detection of Dynamic H₂O₂/H₂S Redox Event in Living Cells and Organisms

Author:
Yang, Lei; Zhang, Yun; Ren, Xiaojie; Wang, Benhua; Yang, Zhaoguang; Song, Xiangzhi; Wang, Wei
Source:
Analytical chemistry 2020 v.92 no.6 pp. 4387-4394
ISSN:
1520-6882
Subject:
mechanism of action,   etc   ; fluorescence; fluorescent dyes; hydrogen peroxide; hydrogen sulfide; image analysis; oxidative stress;     Show all 7 Subjects
Abstract:
... The elusive mechanism of action between signaling molecules H₂O₂ and H₂S in oxidative stress demands a fluorescent probe, capable of their detection in a discriminative and dynamic manner. Herein we report the design and study of a probe TCAB. As demonstrated, it responds to H₂O₂ and H₂S selectively and sensitively to generate distinct fluorescence signals and patterns. Cyan imaging for H₂O₂ in a ...
DOI:
10.1021/acs.analchem.9b05270

16. A developmental cascade perspective of paediatric obesity: A systematic review of preventive interventions from infancy through late adolescence

Author:
St. George, Sara M.; Agosto, Yaray; Rojas, Lourdes M.; Soares, Mary; Bahamon, Monica; Prado, Guillermo; Smith, Justin D.
Source:
Obesity reviews 2020 v.21 no.2 pp. e12939
ISSN:
1467-7881
Subject:
mechanism of action,   etc   ; adolescence; childhood; infancy; lifestyle; obesity; parenting; randomized clinical trials; systematic review; taxonomy;     Show all 10 Subjects
Abstract:
... The goals of this systematic review were to identify and describe paediatric obesity prevention interventions from infancy to late adolescence and to provide recommendations for future intervention research in light of a recently proposed developmental cascade (DC) model of paediatric obesity. We conducted an electronic search of randomized controlled trials with a minimum 6‐month postintervention ...
DOI:
10.1111/obr.12939
PubMed:
31808277
PubMed Central:
PMC6980892

17. Ecotoxicity assessment of microcystins from freshwater samples using a bioluminescent cyanobacterial bioassay

Author:
González-Pleiter, Miguel; Cirés, Samuel; Wörmer, Lars; Agha, Ramsy; Pulido-Reyes, Gerardo; Martín-Betancor, Keila; Rico, Andreu; Leganés, Francisco; Quesada, Antonio; Fernández-Piñas, Francisca
Source:
Chemosphere 2020 v.240 pp. 124966
ISSN:
0045-6535
Subject:
mechanism of action,   etc   ; Anabaena; allelopathy; bioassays; bioluminescence; calcium; drugs; ecotoxicology; freshwater; hepatotoxicity; microcystins; microorganisms; photosynthesis;     Show all 13 Subjects
Abstract:
... The hepatotoxic cyanotoxins microcystins (MCs) are emerging contaminants naturally produced by cyanobacteria. Yet their ecological role remains unsolved, previous research suggests that MCs have allelopathic effects on competing photosynthetic microorganisms, even eliciting toxic effects on other freshwater cyanobacteria. In this context, the bioluminescent recombinant cyanobacterium Anabaena sp. ...
DOI:
10.1016/j.chemosphere.2019.124966

18. Perspective: present pesticide discovery paradigms promote the evolution of resistance – learn from nature and prioritize multi‐target site inhibitor design

Author:
Gressel, Jonathan
Source:
Pest management science 2020 v.76 no.2 pp. 421-425
ISSN:
1526-498X
Subject:
mechanism of action,   etc   ; computer-aided design; databases; evolution; genomics; industry; pesticides;     Show all 7 Subjects
Abstract:
... For many years, the emphasis of industry discovery programs has been on finding new target sites of pesticides and finding pesticides that inhibit single targets. There had been an emphasis on genomics in finding single targets for potential pesticides. There is also the claim that registration of single target inhibiting pesticides is simpler if the mode of action is known. Conversely, if one loo ...
DOI:
10.1002/ps.5649

19. Processivity and the Mechanisms of Processive Endoglucanases

Author:
Wu, Shanshan; Wu, Shufang
Source:
Applied biochemistry and biotechnology 2020 v.190 no.2 pp. 448-463
ISSN:
0273-2289
Subject:
mechanism of action,   etc   ; catalysts; cellulases; cellulose; cellulosic materials; enzymatic hydrolysis; hydrolysis; lignocellulose; oligosaccharides;     Show all 9 Subjects
Abstract:
... Cellulases, as environmentally appropriate catalysts specifically acting on cellulosic substrates, are important for the industrial conversion of lignocellulose and modification of cellulose products. After decades of research, a fundamental understanding of cellulase-mediated hydrolysis of cellulose is that its ability to processively act as a key for the complete enzymatic hydrolysis of natural ...
DOI:
10.1007/s12010-019-03096-w

20. Bilayer Intumescent Paint Metal Laminates: A Novel Design for a High-Performance Fire Barrier

Author:
Geoffroy, Laura; Samyn, Fabienne; Jimenez, Maude; Bourbigot, Serge
Source:
Industrial & engineering chemistry process design and development 2020 v.59 no.7 pp. 2988-2997
ISSN:
1520-5045
Subject:
mechanism of action,   etc   ; aluminum foil; coatings; fire resistance; paints; steel; temperature;     Show all 7 Subjects
Abstract:
... New fire barriers combining the use of two different intumescent paints and a metal laminate structure have been evaluated for the protection of steel. Different bilayer designs have been considered and are composed of an overlay of two intumescent coatings with or without aluminum foils. All laminated bilayers were exposed to fire in a high-temperature environment (116 kW/m²). The design with two ...
DOI:
10.1021/acs.iecr.9b06345