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1. Pd-Catalyzed ipso,meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C–H Activation Cascade with Dimethyl Carbonate as the Methyl Source

Author:
Wu, Zhuo; Wei, Feng; Wan, Bin; Zhang, Yanghui
Source:
Journal of the American Chemical Society 2021 v.143 no.12 pp. 4524-4530
ISSN:
1520-5126
Subject:
medicinal properties,   etc   ; carbon-hydrogen bond activation; methylation;     Show all 3 Subjects
Abstract:
... A methyl group can have a profound impact on the pharmacological properties of organic molecules. Hence, developing methylation methods and methylating reagents is essential in medicinal chemistry. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using dimethyl carbonate as a methyl source. In the presence of K₂CO₃ as a base, iodoarenes are dimethylated at the ...
DOI:
10.1021/jacs.0c13057

2. Deep convolutional neural network for preliminary in-field classification of lichen species

Author:
Galanty, Agnieszka; Danel, Tomasz; Węgrzyn, Michał; Podolak, Irma; Podolak, Igor
Source:
Biosystems engineering 2021 v.204 pp. 15-25
ISSN:
1537-5110
Subject:
medicinal properties,   etc   ; Cladonia; Internet; lichens; neural networks; pollution;     Show all 6 Subjects
Abstract:
... Lichens are unique organisms, valued for their pharmacological activity, but also well known as bioindicators of environmental pollution, key determinants for some natural ecological habitats, or just popular elements of decoration. High morphological similarity between lichen species makes their recognition complicated, especially under in-field conditions. Thus, there is a need for a quick and e ...
DOI:
10.1016/j.biosystemseng.2021.01.004

3. Chemical derivatization of natural products: Semisynthesis and pharmacological aspects- A decade update

Author:
Majhi, Sasadhar; Das, Debjit
Source:
Tetrahedron 2021 v.78 pp. 131801
ISSN:
0040-4020
Subject:
medicinal properties,   etc   ; derivatization; design; lead; materials; medicine; synthesis;     Show all 7 Subjects
Abstract:
... Natural products and their semisynthetic derivatives continue to be an important source of potential drug leads. Natural products and their analogues structures possess the characteristics of high chemical diversity, zenith biochemical specificity, and other significant molecular activities as well as pharmacological properties that create them favorably as lead structures for new drug discovery a ...
DOI:
10.1016/j.tet.2020.131801

4. Advancements in the co-formulation of biologic therapeutics

Author:
Chauhan, Veeren M.; Zhang, Hongyu; Dalby, Paul A.; Aylott, Jonathan W.
Source:
Journal of controlled release 2020 v.327 pp. 397-405
ISSN:
0168-3659
Subject:
medicinal properties,   etc   ; active sites; therapeutics;     Show all 3 Subjects
Abstract:
... Biologic therapeutics are the medicines of the future and are destined to transform the approaches by which the causes and symptoms of diseases are cured and alleviated. These approaches will be accelerated through the development of novel strategies that target multiple pharmacologically active sites using a combination of different biologics, or mixtures of biologics and small molecule therapeut ...
DOI:
10.1016/j.jconrel.2020.08.013

5. Partial Synthesis of Crassicauline A from Yunaconitine

Author:
Zhang, Rong-Ping; Lin, Yan-Jun; Yu, Hao-Fei; Chen, Si-Ying; Zhou, Jun
Source:
Natural products and bioprospecting 2020 v.10 no.2 pp. 105-108
ISSN:
2192-2195
Subject:
medicinal properties,   etc   ; Aconitum; hydrogen; skeleton;     Show all 4 Subjects
Abstract:
... Both Aconitum hemsleyanum and Aconitum geniculatun have abundant contents of yunaconitine (1). Yunaconitine (1) has similar skeleton to crassicauline A (3); the only difference between them is that 1 contains a α-hydroxyl group at C-3. Our team attempts to convert 1 into 3 because 3 owns pharmacological activity. There are two steps to achieve the transformation above: firstly, use dehydration rea ...
DOI:
10.1007/s13659-020-00238-0
PubMed:
32297141
PubMed Central:
PMC7176785

6. Entomotherapy: a study of medicinal insects of seven ethnic groups in Nagaland, North-East India

Author:
Mozhui, Lobeno; Kakati, L. N.; Meyer-Rochow, Victor Benno
Source:
Journal of ethnobiology and ethnomedicine 2021 v.17 no.1 pp. 17
ISSN:
1746-4269
Subject:
medicinal properties,   etc   ; Mylabris; gastritis; humans; medicinal insects; rheumatoid arthritis; stomach; therapeutics; traditional medicine; India;     Show all 10 Subjects
Abstract:
... BACKGROUND: The ethnic communities in Nagaland have kept a close relationship with nature since time immemorial and have traditionally used different kinds of insects and their products as folk medicine to treat a variety of human ills and diseases. The present study was conducted to record the entomotherapeutic practices of seven different ethnic groups of Nagaland. METHOD: Documentation is based ...
DOI:
10.1186/s13002-021-00444-1

7. Combination of electrochemical unit and ESI‐MS in fragmentation of flavonoids

Author:
Sagandykova, Gulyaim N.; Szultka‐Młyńska, Małgorzata; Walczak‐Skierska, Justyna; Pomastowski, Paweł P.; Buszewski, Bogusław
Source:
Phytochemical analysis 2021 v.32 no.4 pp. 601-620
ISSN:
0958-0344
Subject:
medicinal properties,   etc   ; 2,2-diphenyl-1-picrylhydrazyl; antioxidant activity; drugs; electrochemistry; electrospray ionization mass spectrometry; flavonoids; pH;     Show all 8 Subjects
Abstract:
... INTRODUCTION: Predictive approaches on the activity of natural compounds based on the fragmentation by instrumental techniques are important for consideration of such molecules as drug candidates and defining new structures with promising properties. Since flavonoids are well‐known antioxidants, their redox properties can be related to their pharmacological activity. OBJECTIVES: In this work, the ...
DOI:
10.1002/pca.3009

8. A review on β-carboline alkaloids and their distribution in foodstuffs: A class of potential functional components or not?

Author:
Xie, Zhejun; Cao, Ning; Wang, Changhong
Source:
Food chemistry 2021 v.348 pp. 129067
ISSN:
0308-8146
Subject:
medicinal properties,   etc   ; antioxidants; central nervous system; food chemistry; food intake; information; toxicology;     Show all 7 Subjects
Abstract:
... Pharmacologically active β-carboline alkaloids (βCs) such as harman, norharman and some others are naturally present in plants and occur in many foodstuffs. They have a lot of pharmacological properties, including antitumor, antioxidant, anti-inflammatory and antimicrobial effects, and possess the potential for treating Alzheimer’s disease, Parkinson’s disease, depression and other central nervous ...
DOI:
10.1016/j.foodchem.2021.129067

9. Chrysin Inhibits Pseudo-allergic Reaction by Suppressing Mitochondrial STAT3 Activation via MAS-Related GPR Family Member X2

Author:
Zhang, Yongjing; Xue, Zhuoyin; Hu, Shiling; Bai, Haoyun; Wang, Jue; Wang, Nan
Source:
Journal of agricultural and food chemistry 2021 v.69 no.23 pp. 6569-6577
ISSN:
1520-5118
Subject:
medicinal properties,   etc   ; adenosine; anaphylaxis; calcium; chrysin; dose response; food chemistry; glycolysis; mitochondria; serine;     Show all 10 Subjects
Abstract:
... Chrysin, one of the most pharmacologically active natural flavonoids, has been extracted from various plants. Mast cells are an important part of innate immunity-mediating anaphylaxis. Pseudo-allergic reactions are currently believed to be associated with the MAS-related GPR family member X2 (MrgX2). In this study, the anti-pseudo allergy effect of chrysin and its underlying mechanisms were studie ...
DOI:
10.1021/acs.jafc.1c02565

10. Biotransformation of the total flavonoid extract of epimedium into icaritin by two thermostable glycosidases from Dictyoglomus thermophilum DSM3960

Author:
Zhang, Shanshan; Luo, Jianianhua; Dong, Yurong; Wang, Zhenzhong; Xiao, Wei; Zhao, Linguo
Source:
Process biochemistry 2021 v.105 pp. 8-18
ISSN:
1359-5113
Subject:
medicinal properties,   etc   ; ; Dictyoglomus thermophilum; Epimedium; biotransformation; icariin; moieties; pH; thermal stability;     Show all 9 Subjects
Abstract:
... The thermostable GH78 family α-L-rhamnosidase DthRha from Dictyoglomus thermophilum DSM3960 was found to have the ability to remove the α-L-rhamnose moiety that was directly linked to the aglycone by an α-1-rhamnosidic bond at the C-3 position of epimedium flavonoids. It exhibited high specific activity on p-nitrophenyl-α-L-rhamnopyranoside (pNPR) (281.06 U/mg), followed by epimedin C (30.42 U/mg) ...
DOI:
10.1016/j.procbio.2021.03.002

11. Method development for the identification of methoxpropamine, 2-fluoro-deschloroketamine and deschloroketamine and their main metabolites in blood and hair and forensic application

Author:
Mestria, Serena; Odoardi, Sara; Biosa, Giulia; Valentini, Valeria; Di Masi, Gerardo; Cittadini, Francesca; Strano-Rossi, Sabina
Source:
Forensic science international 2021 v.323 pp. 110817
ISSN:
0379-0738
Subject:
medicinal properties,   etc   ; blood; forensic sciences; illicit drugs; ketamine; liquid chromatography; markets; metabolites; pharmacokinetics; public health; suicide;     Show all 11 Subjects
Abstract:
... The constant increase of new psychoactive substances, often available on the illicit drug market as 'research chemicals', poses a concern for public health and a significant analytical and legislative challenge. Β-keto-arylcyclohexamines represent a class of dissociative anesthetics recently introduced on the market of New Psychoactive Substances (NPS). There is still a lack of information about t ...
DOI:
10.1016/j.forsciint.2021.110817

12. Phytochemistry, pharmacological activity, and potential health benefits of Glycyrrhiza glabra

Author:
Hasan, Md. Kamrul; Ara, Iffat; Mondal, Muhammad Shafiul Alam; Kabir, Yearul
Source:
Heliyon 2021 v.7 no.6 pp. e07240
ISSN:
2405-8440
Subject:
medicinal properties,   etc   ; Glycyrrhiza glabra; anticoagulant activity; cosmetics; glycyrrhizin; licorice; obesity; parasympatholytics; phytochemicals; therapeutics; toxicity;     Show all 11 Subjects
Abstract:
... Nature has always been an excellent source for many therapeutic compounds providing us with many medicinal plants and microorganisms producing beneficial chemicals. Therefore, the demand for medicinal plants, cosmetics, and health products is always on the rise. One such plant from the Leguminosae family is licorice and the scientific name is Glycyrrhiza glabra Linn. It is an herb-type plant with ...
DOI:
10.1016/j.heliyon.2021.e07240

13. Essential oils from the genus Thymus as antimicrobial food preservatives: Progress in their use as nanoemulsions-a new paradigm

Author:
Pandey, Abhay K.; Chávez-González, Mónica L.; Silva, Ana Sanches; Singh, Pooja
Source:
Trends in food science & technology 2021 v.111 pp. 426-441
ISSN:
0924-2244
Subject:
medicinal properties,   etc   ; antioxidant activity; antioxidants; biodegradation; food industry; food preservation; laws and regulations; public health;     Show all 8 Subjects
Abstract:
... The biodeterioration of food commodities by microbial pathogens remains a major public health concern. Worldwide, investigations have been carried out to develop harmless natural food preservatives based on essential oils (EOs) to protect food commodities, and advances have been made to meet users’ acceptance as a substitute for synthetic preservatives.In recent years, antimicrobial and antioxidan ...
DOI:
10.1016/j.tifs.2021.02.076

14. Translocation of heavy metals in medicinally important herbal plants growing on complex organometallic sludge of sugarcane molasses-based distillery waste

Author:
Tripathi, Sonam; Sharma, Pooja; Singh, Kshitij; Purchase, Diane; Chandra, Ram
Source:
Environmental technology & innovation 2021 v.22 pp. 101434
ISSN:
2352-1864
Subject:
medicinal properties,   etc   ; Amaranthus viridis; Basella alba; Momordica; Sesbania bispinosa; environmental technology; sludge; sugarcane;     Show all 8 Subjects
Abstract:
... This study aimed to assess the heavy metals accumulation patterns by some native plants such as Achyranthus aspera L., Amaranthus viridis, Basella alba L., Sesbania bispinosa, Pedalium murex L., and Momordica doica, which have been traditionally employed for medicinal and food purposes. The plants were grown on complex distillery waste containing a mixture of organometallic compounds. Results reve ...
DOI:
10.1016/j.eti.2021.101434

15. Recent advances in the determination of unbound concentration and plasma protein binding of drugs: Analytical methods

Author:
Seyfinejad, Behrouz; Ozkan, Sibel A.; Jouyban, Abolghasem
Source:
Talanta 2021 v.225 pp. 122052
ISSN:
0039-9140
Subject:
medicinal properties,   etc   ; analytical methods; blood; blood flow; blood proteins; drugs; monitoring; precision medicine;     Show all 8 Subjects
Abstract:
... Drugs in the bloodstream are available in both free and bound forms in which the free drug is responsible for pharmacological activities. Since protein binding determines the amount of free concentration of the drug in the blood, determining the protein binding in the early stages of drug discovery and development is of great importance. Besides, it is most beneficial to measure the free concentra ...
DOI:
10.1016/j.talanta.2020.122052

16. Nanotechnology for delivery of natural therapeutic substances: a review

Author:
Saka, Raju; Chella, Naveen
Source:
Environmental chemistry letters 2021 v.19 no.2 pp. 1097-1106
ISSN:
1610-3653
Subject:
medicinal properties,   etc   ; artemisinin; diabetes; environmental science; inflammation; medicine; nanocarriers; permeability; pharmacokinetics; psoriasis; resveratrol; silymarin; solubility; thymoquinone;     Show all 14 Subjects
Abstract:
... The use of natural compounds in medicine for the treatment of diseases started since ancient days. Though many natural compounds exhibit potent pharmacological activity, their medicinal application is limited by low solubility, permeability or stability. Therefore, pharmaceutical scientists are developing drug delivery systems and carriers that allow better efficacy and clinical success. For insta ...
DOI:
10.1007/s10311-020-01103-9

17. Preparative isolation of 1,1‐diphenyl‐2‐picrylhydrazyl inhibitors from Ribes himalense using medium‐pressure and two‐dimensional reversed‐phase/reversed‐phase liquid chromatography guided by an online HPLC‐1, 1‐diphenyl‐2‐picrylhydrazyl assay

Author:
Liu, Chuang; Lei, Yuqing; Dang, Jun; Wang, Weidong; Zhang, Jing; Mei, Lijuan; Liu, Zenggen; Tao, Yanduo; Shao, Yun
Source:
Journal of separation science 2021 v.44 no.7 pp. 1345-1352
ISSN:
1615-9306
Subject:
medicinal properties,   etc   ; 2,2-diphenyl-1-picrylhydrazyl; Oriental traditional medicine; Ribes; free radicals; liquids; separation;     Show all 7 Subjects
Abstract:
... The lack of suitable chromatographic purification methods makes it a challenge to effectively isolate the chemical components of traditional Tibetan medicines. Ribes himalense is a rarely studied Tibetan medicine, reputed to have free radical‐scavenging effects. In the present work, we utilized it as a model herb to highlight an approach for the separation of 1,1‐diphenyl‐2‐picrylhydrazyl inhibito ...
DOI:
10.1002/jssc.202001080

18. Integrative review on ethnobotany, essential oil, phytochemical, agronomy, molecular and pharmacological properties of Satureja species

Author:
Sefidkon, Fatemeh; Emami Bistgani, Zohreh
Source:
TheJournal of essential oil research 2021 v.33 no.2 pp. 114-132
ISSN:
2163-8152
Subject:
medicinal properties,   etc   ; Satureja; agronomy; antioxidants; antiparasitic agents; carvacrol; cytotoxicity; essential oils; ethnobotany; odors; research; thymol;     Show all 12 Subjects
Abstract:
... Satureja is one of the important medicinal and aromatic genus of the Lamiaceae family due to the high valuable phenolic compounds, such as carvacrol and thymol, which is produced by the plants. It is considered as an important potential source of nutrient and valuable components thus, can serve to control some diseases such as antioxidant, antifungal, antibacterial, antiparasitic, antiviral, anti- ...
DOI:
10.1080/10412905.2021.1885512

19. Potential modulating effect of the Ascaris suum nicotinic acetylcholine receptor (nAChR) by compounds GSK575594A, diazepam and flumazenil discovered by structure-based virtual screening approach

Author:
Stevanovic, Strahinja; Marjanović, Djordje S.; Trailović, Sasa M.; Zdravković, Nemanja; Perdih, Andrej; Nikolic, Katarina
Source:
Molecular and biochemical parasitology 2021 v.242 pp. 111350
ISSN:
0166-6851
Subject:
medicinal properties,   etc   ; Ascaris suum; acetylcholine; anthelmintics; choline; computer simulation; databases; diazepam; models; muscles; nicotinic receptors; parasitology;     Show all 12 Subjects
Abstract:
... Parasitic infections are a widespread health problem and research of novel anthelmintic compounds is of the utmost importance. In this study we performed a virtual screening campaign by coupling ligand-based pharmacophore, homology modeling and molecular docking. The virtual screening campaign was conducted using a joined pool of the Drugbank database and a library of purchasable compounds in orde ...
DOI:
10.1016/j.molbiopara.2021.111350

20. Sedative effects of l-menthol, d-camphor, phenylethyl alcohol, and geraniol

Author:
Oshima, Tomoko; Ito, Michiho
Source:
Natural medicines 2021 v.75 no.2 pp. 319-325
ISSN:
1340-3443
Subject:
medicinal properties,   etc   ; breathing; cages; dose response; eyes; geraniol; odors; phenylethyl alcohol; sedatives;     Show all 9 Subjects
Abstract:
... Various essential oils from plants and fragrance components such as monoterpenes have been discovered to reduce spontaneous movements in mice; thus, it has been made clear that the odor itself has the sedative activity. In the present study, we examined the sedative activity of the odors of fragrance components added to eye drops; l-menthol, d-camphor, phenylethyl alcohol, and geraniol, which are ...
DOI:
10.1007/s11418-020-01470-1