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medicinalproperties, etc ; food safety; glycyrrhizin; ice cream; ingestion; licorice; markets; risk; sweets; tea; Denmark; Show all 11 Subjects
Abstract:
... Glycyrrhizinic acid (GA) is a natural compound found in licorice root and its extract, and is used in a large number of food products. It has been documented that excess consumption of licorice can cause adverse health effects, due to their content of GA. Mandatory labelling rules are therefore in place in the EU to inform consumers of the possible adverse health effects. In this study, 219 sample ...
... The α,γ-disubstituted butenolides are widespread occurrences in numerous pharmacologically active molecules. In this paper, a highly efficient method for the synthesis of α,γ-disubstituted butenolide derivatives via a direct α-addition cascade isomerization of deconjugated butenolides with α-ketoesters using Et₃N as catalyst, has been successfully developed. A series of α,γ-disubstituted butenolid ...
medicinalproperties, etc ; heterocyclic compounds; nanoparticles; Show all 3 Subjects
Abstract:
... One important class of heterocyclic compounds, are pyrazole derivatives. These compounds consist of a pyrazole core and have many biological and pharmacological activities. Also, some of natural products having pyrazole molecules in their structures that give particular properties to these compounds. Today, interesting to nanoparticles due to the special characteristics of them for the organic syn ...
medicinalproperties, etc ; antimalarials; chemoselectivity; regioselectivity; Show all 4 Subjects
Abstract:
... This article reports the regioselective and chemoselective synthesis of 4,5-dialkoxy-2-nitroanilines substituted with two alkoxys at C-4 and C-5. Here we show the optimization protocol of the transetherification reaction used to synthesize 20 new compounds with good to excellent yields (50–92%). We describe a simple and efficient one-step procedure that can be applied to obtain a significant numbe ...
medicinalproperties, etc ; chalcones; derivatization; phenol; skeleton; stilbenes; Show all 6 Subjects
Abstract:
... Structural derivatization of natural products has been a continuing and irreplaceable source of novel drug leads. Natural phenols are a broad category of natural products with wide pharmacological activity and have offered plenty of clinical drugs. However, the structural complexity and wide variety of natural phenols leads to the difficulty of structural derivatization. Skeleton analysis indicate ...
medicinalproperties, etc ; antioxidants; intestinal microorganisms; medicine; polysaccharides; therapeutics; Show all 6 Subjects
Abstract:
... 110 kinds of traditional Chinese medicines can be used for medicine and food from Chinese pharmacopoeia in 2021. With the deepening of research in recent years, medicinal and edible homologous (MEH) traditional Chinese medicines have great development and application prospects in many fields. Polysaccharides are one of the major and representative pharmacologically active macromolecules in traditi ...
medicinalproperties, etc ; brain; cyclodextrins; ingredients; medicine; neurons; pH; phenobarbital; solubility; Show all 9 Subjects
Abstract:
... The interest in the photochromism and functional applications of donor–acceptor Stenhouse adducts (DASAs) soared in recent years owing to their outstanding advantages and flexible design. However, their low solubility and irreversible conversion in aqueous solutions hampered exploring DASAs for biology and medicine. It is notably unknown whether the barbiturate electron acceptor group retains the ...
medicinalproperties, etc ; Coriolus versicolor; active ingredients; fungi; immune response; polysaccharides; Show all 6 Subjects
Abstract:
... Coriolus is the dried fruiting body of Coriolus versicolor (L. ex Fr.) Quel. C. versicolor (CV) is a worldwide-distributed fungus, which is common and widely used in primitive forests in the northern hemisphere. Polysaccharide, as the main active ingredient in CV, has a variety of biological activities, such as promoting immune function, antivirus, antitumor, anti-diabetes, and so on. However, Cor ...
medicinalproperties, etc ; durability; half life; heparin; patient compliance; therapeutics; thrombosis; Show all 7 Subjects
Abstract:
... Heparin, a sulfate-containing linear polysaccharide, has proven preclinical and clinical efficacy for a variety of disorders. Heparin, including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), and ultra-low-molecular-weight heparin (ULMWH), is administered systematically, in the form of a solution in the clinic. However, it is eliminated quickly, due to its short half-life, espe ...
medicinalproperties, etc ; Centella asiatica; cytotoxicity; flavonols; humans; medicinal plants; spectroscopy; Show all 7 Subjects
Abstract:
... Centella asiatica is well known as an important medicinal plant because of its various pharmacological effects. However, most investigations on C. asiatica focused on the pharmacological activity of its extract or asiatic acid. In the present work, we aimed to explore the bioactive compounds of the whole plants of C. asiatica. As a result, seven compounds including two new flavonol derivates named ...
medicinalproperties, etc ; acyltransferases; biotechnology; catalytic activity; heterologous gene expression; lipids; solubility; Show all 7 Subjects
Abstract:
... Acyltransferases (ATs) are important tailoring enzymes that contribute to the diversity of natural products. They catalyze the transfer of acyl groups to the skeleton, which improves the lipid solubility, stability, and pharmacological activity of natural compounds. In recent years, a number of ATs have been isolated from plants. In this review, we have summarized 141 biochemically characterized A ...
medicinalproperties, etc ; Scutellaria; antifeedants; diterpenoids; flavonoids; metabolites; nitric oxide; phytotoxicity; therapeutics; Show all 9 Subjects
Abstract:
... Scutellaria genus, a member of the Lamiaceae family, distributed worldwide and known as skullcaps, contains a wide range of pharmacologically active constituents including flavonoids and diterpenes. There are different classes of diterpenes in the plant kingdom, of which many have medicinal applications. Scutellaria spp. contain neo-clerodane diterpenes, a large group of naturally occurring specia ...
medicinalproperties, etc ; Aloe; active ingredients; antioxidants; mechanism of action; phytotherapy; research; toxicology; Show all 8 Subjects
Abstract:
... The Aloe species is known for its medicinal and cosmetic properties. Aloin is an active ingredient found in the leaves of medicinal plants of the genus Aloe. Aloin has attracted considerable interest for its antiinflammatory, anticancer, antibacterial, and antioxidant activities. However, since its clinical application is restricted by its unclear mechanism of action, a deeper understanding of its ...
medicinalproperties, etc ; agonists; antagonists; brain; calcium; drugs; endoplasmic reticulum; ligands; neurites; therapeutics; toxicology; Show all 11 Subjects
Abstract:
... The Sigma-1 receptor (S1R) is an endoplasmic reticulum (ER) chaperone protein that has been implicated in attenuating inflammatory stress-mediated brain injuries. Selective S1R agonists represent a new class of therapeutic agent for treating neuropsychiatric and neurodegenerative disorders, however, to date, no S1R ligand has been approved for therapeutic purposes. We used three potential methods ...
medicinalproperties, etc ; Candida; Tephrosia; chromatography; computer simulation; enzyme substrates; flavonoids; methanol; multiple drug resistance; Show all 9 Subjects
Abstract:
... Tephrosia is widely distributed throughout tropical, subtropical, and arid regions. This genus is known for several biological activities, including its anti-Candida activity, which is mainly attributed to prenylated flavonoids. The biological activities of most Tephrosia species have been studied, except T. apollinea. This study was conducted to investigate the underlying anti-Candida activity of ...
medicinalproperties, etc ; Aegle marmelos; comparative study; ethanol; evolution; leaves; oxidoreductases; phytochemicals; quantitative analysis; India; Show all 10 Subjects
Abstract:
... Aegle marmelos is a traditional plant belonging to India. Very few and sporadic works are there in the literature regarding the physicochemical evaluation of the plant. The major parameters of this study includes the quantification marmelosine, WHO-recommended physicochemical investigation, preliminary phytochemical examination and chemical profiling using advanced techniques like HPLC, LC-MS, and ...
medicinalproperties, etc ; flavonoids; food composition; honey; liquid chromatography; mass spectrometry; polyphenols; qualitative analysis; surveys; Show all 9 Subjects
Abstract:
... Over the past decade, the measurement of phenolics and flavonoids in honey has received much attention, which is attributed to their broad spectrum of beneficial pharmacological activity and their potential to address issues related to the authenticity and botanical origin of honey. Due to their high variability in structural and physicochemical properties, the separation, detection and identifica ...
medicinalproperties, etc ; apigenin; biodiversity; diabetes mellitus; glycemic effect; kaempferol; metabolites; quercetin; traditional medicine; triterpenoids; Africa; Show all 11 Subjects
Abstract:
... Africa has a rich biodiversity of plants and an active traditional medicine system that takes advantage of the rich biodiversity to treat various diseases, including diabetes mellitus (DM). The folkloric use of some of these plants in treating diabetes has been documented in various databases and publications, and validated with in vitro and in vivo models. In this regard ethnopharmacology remains ...
medicinalproperties, etc ; Agave; bioinformatics; chemistry; immunomodulation; inflammation; macrophages; phosphatidylinositol 3-kinase; research; steroid saponins; Mexico; Show all 11 Subjects
Abstract:
... Agave marmorata Roezl is an endemic succulent specie from the Oaxaca-Puebla area of Mexico. This plant is a medicinal recourse and contain a rich variety of saponins-type compounds with multiples biological effects. Some of them have been shown to be anticancer, antibacterial, or having anti-inflammatory and immunoregulation effects. This paper is the first scientific report to describe the pharma ...
medicinalproperties, etc ; Orchidaceae; abortion (animals); antioxidant activity; cough; diabetes; flavonoids; labor; phenol; principal component analysis; Mexico; Show all 11 Subjects
Abstract:
... The orchid Prosthechea karwinskii is a medicinal orchid in Oaxaca, Mexico, used to treat diabetes, cough, wounds, and burns, prevent miscarriage and assist in labor. Each part of the plant (leaves, pseudobulbs, or flowers) is used by healers for certain treatment conditions, indicating that each part has different biocompounds with specific pharmacological activity. To characterize the biocompound ...