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1. Nitroketene N,S-acetals: synergistic building blocks for the synthesis of heterocycles

Author:
Saigal,; Khan, Sarfaraz; Rahman, Habibur; Shafiullah,; Khan, Md. Musawwer
Source:
RSC advances 2019 v.9 no.25 pp. 14477-14502
ISSN:
2046-2069
Subject:
medicinal properties,   etc   ; chemistry; heterocyclic compounds;     Show all 3 Subjects
Abstract:
... The development of novel heterocyclic compounds from simple and easily accessible starting components is of significant importance in medicinal chemistry. Due to the presence of active chromophores and potent pharmacological activities, nitroketene N,S-acetals have emerged as a fascinating building block in organic synthesis. The synergistic skeleton of these acetals and the presence of electron-d ...
DOI:
10.1039/c9ra00630c

2. Future prospects for noncanonical amino acids in biological therapeutics

Author:
Rezhdo, Arlinda; Islam, Mariha; Huang, Manjie; Van Deventer, James A
Source:
Current opinion in biotechnology 2019 v.60 pp. 168-178
ISSN:
0958-1669
Subject:
medicinal properties,   etc   ; amino acids; chemistry; proteins; therapeutics;     Show all 5 Subjects
Abstract:
... There is growing evidence that noncanonical amino acids (ncAAs) can be utilized in the creation of biological therapeutics ranging from protein conjugates to cell-based therapies. However, when does genetically encoding ncAAs yield biologics with unique properties compared to other approaches? In this review, we attempt to answer this question in the broader context of therapeutic development, emp ...
DOI:
10.1016/j.copbio.2019.02.020

3. miRNA inhibition by proximity-enabled Dicer inactivation

Author:
Yan, Hao; Liang, Fu-Sen
Source:
Methods 2019
ISSN:
1046-2023
Subject:
medicinal properties,   etc   ; biogenesis; human diseases; microRNA; therapeutics;     Show all 5 Subjects
Abstract:
... microRNAs (miRNAs) are considered as master regulators of biological processes. Dysregulation of miRNA expression has been implicated in many human diseases. Driven by the key biological roles and the therapeutic potential, developing methods for miRNA regulation has become an intense research area. Due to favorable pharmacological properties, small molecule-based miRNA inhibition emerges as a pro ...
DOI:
10.1016/j.ymeth.2019.05.004

4. Progress in the Chemistry of Tetrahydroquinolines

Author:
Muthukrishnan, Isravel; Sridharan, Vellaisamy; Menéndez, J. Carlos
Source:
Chemical reviews 2019 v.119 no.8 pp. 5057-5191
ISSN:
1520-6890
Subject:
medicinal properties,   etc   ; active ingredients; heterocyclic nitrogen compounds;     Show all 3 Subjects
Abstract:
... Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, being widespread in nature and present in a broad variety of pharmacologically active compounds. This Review summarizes the progress achieved in the chemistry of tetrahydroquinolines, with emphasis on their synthesis, during the period from mid-2010 to early 2018. ...
DOI:
10.1021/acs.chemrev.8b00567

5. Scalable Total Synthesis of (−)-Vinigrol

Author:
Yu, Xuerong; Xiao, Lianghong; Wang, Zechun; Luo, Tuoping
Source:
Journal of the American Chemical Society 2019 v.141 no.8 pp. 3440-3443
ISSN:
1520-5126
Subject:
medicinal properties,   etc   ; stereochemistry; tumor necrosis factor-alpha;     Show all 3 Subjects
Abstract:
... Vinigrol is a structurally and stereochemically complex natural product that displays various potent pharmacological activities, including the capability to modulate TNF-α. A new and efficient synthetic route toward this natural product has been developed to complete the asymmetric synthesis of (−)-vinigrol and provide over 600 mg of material, manifesting the power of macrocyclic stereocontrol and ...
DOI:
10.1021/jacs.9b00621

6. Isolation of erythrinan alkaloids from the leaves and flowers of Erythrina speciosa

Author:
Amaral, Patrícia de Aguiar; Antunes, Altamir R.; Barlow, James W.
Source:
Revista Brasileira de Farmacognosia 2019
ISSN:
0102-695X
Subject:
medicinal properties,   etc   ; Erythrina speciosa; alkaloids; flowers; leaves;     Show all 5 Subjects
Abstract:
... In this paper, we describe the extraction of three alkaloids from the leaves and flowers of Erythrina speciosa Andrews, Fabaceae, a plant documented in the literature to possess a range of potential medicinal applications. Two alkaloids were isolated from both leaves and flowers, with erythrartine being isolated from both plant parts. In agreement with the literature, we also isolated erysotrine f ...
DOI:
10.1016/j.bjp.2019.01.007

7. Correction to: The antiangiogenic activities of ethanolic crude extracts of four Salvia species

Author:
Zihlif, Malek; Afifi, Fatma; Abu-Dahab, Rana; Majid, Amin Malik Shah Abdul; Somrain, Hamza; Saleh, Mohanad M.; Nassar, Zeyad D.; Naffa, Randa
Source:
BMC complementary and alternative medicine 2018 v.18 no.1 pp. 64
ISSN:
1472-6882
Subject:
medicinal properties,   etc   ; Salvia; plant extracts;     Show all 3 Subjects
Abstract:
... CORRECTION: After the publication [1] it came to the attention of the authors that one of the co-authors was incorrectly included as Hamza Somrain. The correct spelling is as follows: Hamzeh Sumrein. ...
DOI:
10.1186/s12906-018-2126-8
PubMed:
29452588
PubMed Central:
PMC5815194

8. Correction to: Ceramicines M–P from Chisocheton ceramicus: isolation and structure–activity relationship study

Author:
Nugroho, Alfarius Eko; Hashimoto, Akiyo; Wong, Chin-Piow; Yokoe, Hiromasa; Tsubuki, Masayoshi; Kaneda, Toshio; Hadi, A. Hamid A.; Morita, Hiroshi
Source:
Natural medicines 2019 v.73 no.3 pp. 682
ISSN:
1340-3443
Subject:
medicinal properties,   etc   ; Chisocheton; herbal medicines; structure-activity relationships;     Show all 4 Subjects
Abstract:
... The article Ceramicines M–P from Chisocheton ceramicus: isolation and structure–activity relationship study. ...
DOI:
10.1007/s11418-019-01301-y

9. Correction to: Elicitation of Isatis tinctoria L. hairy root cultures by salicylic acid and methyl jasmonate for the enhanced production of pharmacologically active alkaloids and flavonoids

Author:
Gai, Qing-Yan; Jiao, Jiao; Wang, Xin; Zang, Yu-Ping; Niu, Li-Li; Fu, Yu-Jie
Source:
Plant cell, tissue, and organ culture 2019 v.137 no.2 pp. 417
ISSN:
0167-6857
Subject:
medicinal properties,   etc   ; Isatis tinctoria; alkaloids; flavonoids; methyl jasmonate; salicylic acid;     Show all 6 Subjects
Abstract:
... In the original publication, only affiliation number 2 was indicated as the last author’s affiliation. In fact, the author works for both affiliations. ...
DOI:
10.1007/s11240-019-01610-w

10. Assembling of medium/long chain-based β-arylated unnatural amino acid derivatives via the Pd(II)-catalyzed sp3β-C-H arylation and a short route for rolipram-type derivatives

Author:
Tomar, Radha; Bhattacharya, Debabrata; Babu, Srinivasarao Arulananda
Source:
Tetrahedron 2019 v.75 no.17 pp. 2447-2465
ISSN:
0040-4020
Subject:
medicinal properties,   etc   ; amino acid derivatives; arylation; gamma-aminobutyric acid; moieties;     Show all 5 Subjects
Abstract:
... In this paper, we report the assembling of libraries of β-arylated short/medium/long chain-based non-α-amino acid (aminoalkanoic acid) derivatives via the Pd(II)-catalyzed, bidentate directing group 8-aminoquinoline-aided sp3β-C-H activation/arylation method. Short/medium chain-based unnatural amino acid derivatives containing an aryl group at the β-position are promising small molecules with ther ...
DOI:
10.1016/j.tet.2019.03.018

11. Friedel-Crafts Alkylation of Indoles with Trichloroacetimidates

Author:
Suzuki, Tamie; Chisholm, John D.
Source:
Tetrahedron letters 2019
ISSN:
0040-4039
Subject:
medicinal properties,   etc   ; Lewis acids; alkylation; chemical structure; indoles;     Show all 5 Subjects
Abstract:
... Substituted indole scaffolds are often utilized in medicinal chemistry as they regularly possess significant pharmacological activity. Therefore the development of simple, inexpensive and efficient methods for alkylating the indole heterocycle continues to be an active research area. Reported are reactions of trichloroacetimidate electrophiles and indoles to address the challenges of accessing alk ...
DOI:
10.1016/j.tetlet.2019.04.007

12. Enantioselective activity of usnic acid: a comprehensive review and future perspectives

Author:
Galanty, Agnieszka; Paśko, Paweł; Podolak, Irma
Source:
Phytochemistry reviews 2019 v.18 no.2 pp. 527-548
ISSN:
1568-7767
Subject:
medicinal properties,   etc   ; enantiomers; enantioselectivity; structure-activity relationships; usnic acid;     Show all 5 Subjects
Abstract:
... This review is focused on the comparison of the biological and pharmacological activities of usnic acid enantiomers. Most of the available data refer to (+)-usnic acid, while the left-handed isomer has been less often significantly studied. Special attention was paid to the experiments comparing both (+)- and (−)-usnic acid at the same time, the results of which indicated interesting differences, ...
DOI:
10.1007/s11101-019-09605-3

13. Chemical and pharmacological comparison of modern and traditional dosage forms of Joshanda

Author:
Parveen, Sajida; Irfan Bukhari, Nadeem; Shehzadi, Naureen; Qamar, Shaista; Ali, Ejaz; Naheed, Surriya; Latif, Abida; Yuchi, Alamgeer; Hussain, Khalid
Source:
Natural product research 2019 v.33 no.6 pp. 858-861
ISSN:
1478-6427
Subject:
medicinal properties,   etc   ; antibacterial properties; chromatography; drug formulations; metabolome; spectroscopy;     Show all 6 Subjects
Abstract:
... Recently, a traditional remedy (Joshanda) has been replaced largely by modern ready-to-use dosage forms, which have not been compared to the original remedy. Therefore, the present study aimed to compare a number of modern dosage forms with traditional remedy. Seven brands, 3 batches each, were compared with a Lab-made formulation with reference to analytical (proximate analyses, spectroscopic and ...
DOI:
10.1080/14786419.2017.1408103

14. An environmentally benign multi-component reaction: regioselective synthesis of fluorinated 2-aminopyridines using diverse properties of the nitro group

Author:
Du, Xuan-Xuan; Zi, Quan-Xing; Wu, Yu-Meng; Jin, Yi; Lin, Jun; Yan, Sheng-Jiao
Source:
Green chemistry 2019 v.21 no.6 pp. 1505-1516
ISSN:
1463-9270
Subject:
medicinal properties,   etc   ; benzaldehyde; cyclization reactions; green chemistry; nitro compounds; regioselectivity;     Show all 6 Subjects
Abstract:
... An efficient and concise one-pot procedure was developed for the synthesis of two kinds of fluorinated 2-aminopyridine compounds, 4 and 5, based on the reactions of different types of 1,1-enediamines (EDAMs), 1, with a variety of benzaldehyde derivatives, 2, and 1,3-dicarbonyl compounds, 3, involving the Knoevenagel, Michael and cyclization reactions under heating. This protocol is especially suit ...
DOI:
10.1039/c8gc03698e

15. Myths, reality and future of mesenchymal stem cell therapy

Author:
Poltavtseva, R. A.; Poltavtsev, A. V.; Lutsenko, G. V.; Svirshchevskaya, E. V.
Source:
Cell and tissue research 2019 v.375 no.3 pp. 563-574
ISSN:
0302-766X
Subject:
medicinal properties,   etc   ; inflammation; mesenchymal stromal cells; therapeutics; tissue repair;     Show all 5 Subjects
Abstract:
... Mesenchymal stem cell (MSC) therapy represents an alternative approach for tissue regeneration and inflammation control. In spite of a huge amount of preclinical data that has been accumulated on the therapeutic properties of MSCs, there are many conflicting results, possibly due to differences in the properties of MSCs obtained from different sources or underestimated mechanisms of MSC in vivo be ...
DOI:
10.1007/s00441-018-2961-4

16. Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges

Author:
Vinogradov, Alexander A.; Yin, Yizhen; Suga, Hiroaki
Source:
Journal of the American Chemical Society 2019 v.141 no.10 pp. 4167-4181
ISSN:
1520-5126
Subject:
medicinal properties,   etc   ; amino acids; drugs; macrocyclization reactions; peptides; permeability; therapeutics;     Show all 7 Subjects
Abstract:
... Peptides as a therapeutic modality attract much attention due to their synthetic accessibility, high degree of specific binding, and the ability to target protein surfaces traditionally considered “undruggable”. Unfortunately, at the same time, other pharmacological properties of a generic peptide, such as metabolic stability and cell permeability, are quite poor, which limits the success of de no ...
DOI:
10.1021/jacs.8b13178

17. Technologies of the Body in Contemporary Ayahuasca Shamanism in the Peruvian Amazon: Implications for Future Research

Author:
Fotiou, Evgenia
Source:
Human ecology 2019 v.47 no.1 pp. 145-151
ISSN:
0300-7839
Subject:
medicinal properties,   etc   ; herbal medicines; medicinal plants; Amazonia; Peru;     Show all 5 Subjects
Abstract:
... Ayahuasca is a psychoactive plant mixture used in a ceremonial context throughout WesternAmazonia whose use has expanded globally in recent decades becoming popular among westerners whotravel to the Peruvian Amazon in increasing numbers to experience its reportedly healing andtransformative effects. The experience often involves participating in a shamanic dieta, which involvesfasting and ingestin ...
DOI:
10.1007/s10745-018-0043-6

18. Improved magnetic regulation of delivery profiles from ferrogels

Author:
Kennedy, Stephen; Roco, Charles; Déléris, Alizée; Spoerri, Patrizia; Cezar, Christine; Weaver, James; Vandenburgh, Herman; Mooney, David
Source:
Biomaterials 2018 v.161 pp. 179-189
ISSN:
0142-9612
Subject:
medicinal properties,   etc   ; hydrogels; magnetism; normal values;     Show all 4 Subjects
Abstract:
... While providing the ability to magnetically enhance delivery rates, ferrogels have not been able to produce the various types of regulated delivery profiles likely needed to direct complex biological processes. For example, magnetically triggered release after prolonged periods of payload retention have not been demonstrated and little has been accomplished towards remotely controlling release rat ...
DOI:
10.1016/j.biomaterials.2018.01.049

19. Structural organization of cycloartane-based saponins in the genus Astragalus (Fabaceae)

Author:
Sarraj-Laabidi, Abir; Lacaille-Dubois, Marie-Aleth; Semmar, Nabil
Source:
Phytochemistry reviews 2018 v.17 no.2 pp. 431-452
ISSN:
1568-7767
Subject:
medicinal properties,   etc   ; Astragalus; acetylation; carbon; glycosylation; saponins;     Show all 6 Subjects
Abstract:
... Cycloartane represents the most common aglycone in saponins of Astragalus genus. These saponins revealed high structural diversity through continuous elucidation of new molecules. Traditionally, saponins’ diversity was updated through reviews listing molecules with respect to their pharmacological activities and/or producing plant species. Beyond the long lists of reviewed molecules, this work pro ...
DOI:
10.1007/s11101-017-9541-1

20. Qualitative and quantitative ethnobotanical study of the Pangkhua community in Bilaichari Upazilla, Rangamati District, Bangladesh

Author:
Faruque, Mohammad Omar; Feng, Gang; Khan, Md Nurul Amin; Barlow, James W.; Ankhi, Umme Ruman; Hu, Sheng; Kamaruzzaman, M.; Uddin, Shaikh Bokhtear; Hu, Xuebo
Source:
Journal of ethnobiology and ethnomedicine 2019 v.15 no.1 pp. 8
ISSN:
1746-4269
Subject:
medicinal properties,   etc   ; digestive system diseases; elderly; ethnobotany; men; quantitative analysis; therapeutics; traditional medicine; women; Bangladesh; Pakistan;     Show all 11 Subjects
Abstract:
... BACKGROUND: The present study documents the ethnomedicinal knowledge among the traditional healers of the Pangkhua indigenous community of Bangladesh. The documented data from this area was quantitatively analyzed for the first time. We aimed to record ethnomedicinal information from both the traditional healers and also the elderly men and women of the community, in order to compile and document ...
DOI:
10.1186/s13002-019-0287-2