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1. Electrospinning for drug delivery applications: A review

Author:
Luraghi, Andrea; Peri, Francesco; Moroni, Lorenzo
Source:
Journal of controlled release 2021 v.334 pp. 463-484
ISSN:
0168-3659
Subject:
precision medicine,   etc   ; drugs; nanofibers;     Show all 3 Subjects
Abstract:
... Drug delivery devices are promising tools in the pharmaceutical field, as they are able to maximize the therapeutic effects of the delivered drug while minimizing the undesired side effects. In the past years, electrospun nanofibers attracted rising attention due to their unique features, like biocompatibility and broad flexibility. Incorporation of active principles in nanofibrous meshes proved t ...
DOI:
10.1016/j.jconrel.2021.03.033

2. Comprehensive evaluation of Licorice extract by five-dimensional quantitative profiling

Author:
Lan, Lili; Sun, Wanyang; Chang, Qian; Sun, Guoxiang
Source:
Journal of chromatography 2021 v.1644 pp. 462105
ISSN:
0021-9673
Subject:
medicine,   etc   ; cluster analysis; licorice;     Show all 3 Subjects
Abstract:
... Licorice extract (LE) is widely used in food and medicine fields. The detection of single chemical component cannot describe its overall quality. In this paper, the content of five active components and HPLC fingerprint of LE was determined. Firstly, the dual-standard system calibration method was proposed to correct the differences between different chromatographic systems. Then, the five-dimensi ...
DOI:
10.1016/j.chroma.2021.462105

3. Centering the Voices of Black Parasitologists During America’s Racial Awakening

Author:
Cordy, Regina Joice
Source:
Trends in parasitology 2021 v.37 no.5 pp. 361-367
ISSN:
1471-4922
Subject:
medicine,   etc   ; hygiene; microbiology; parasitology;     Show all 4 Subjects
Abstract:
... During the fall of 2020, several panel discussions were held to highlight the perspectives of Black parasitologists. Here, I summarize the themes from three such discussions, held at the Molecular Parasitology Meeting, Black in Microbiology Week, and the Annual Meeting of the American Society of Tropical Medicine & Hygiene, respectively. ...
DOI:
10.1016/j.pt.2021.02.006

4. Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer

Author:
Levin, Michael
Source:
Cell 2021 v.184 no.8 pp. 1971-1989
ISSN:
0092-8674
Subject:
medicine,   etc   ; embryogenesis; gene expression;     Show all 3 Subjects
Abstract:
... How are individual cell behaviors coordinated toward invariant large-scale anatomical outcomes in development and regeneration despite unpredictable perturbations? Endogenous distributions of membrane potentials, produced by ion channels and gap junctions, are present across all tissues. These bioelectrical networks process morphogenetic information that controls gene expression, enabling cell col ...
DOI:
10.1016/j.cell.2021.02.034

5. Congenital Tumours and Tumour-Like Lesions in Calves: a Review

Author:
Jacinto, Joana GP.; Bolcato, Marilena; Sheahan, Brian J.; Muscatello, Luisa V.; Gentile, Arcangelo; Avallone, Giancarlo; Benazzi, Cinzia
Source:
Journal of comparative pathology 2021 v.184 pp. 84-94
ISSN:
0021-9975
Subject:
medicine,   etc   ; peritoneum; pregnancy;     Show all 3 Subjects
Abstract:
... Congenital tumours and tumour-like lesions represent a group of rare disorders in both veterinary and human medicine that arise from tissue remnants and are detected during pregnancy or within the first 2–3 months of life. Different forms of congenital tumours and congenital tumour-like lesions have been reported in calves and their development is poorly understood. They often pose a diagnostic ch ...
DOI:
10.1016/j.jcpa.2021.02.003

6. Bone regeneration via skeletal cell lineage plasticity: All hands mobilized for emergencies: Quiescent mature skeletal cells can be activated in response to injury and robustly participate in bone regeneration through cellular plasticity

Author:
Matsushita, Yuki; Ono, Wanida; Ono, Noriaki
Source:
BioEssays 2021 v.43 no.1 pp. e2000202
ISSN:
0265-9247
Subject:
medicine,   etc   ; adults; osteoblasts; plasticity;     Show all 4 Subjects
Abstract:
... An emerging concept is that quiescent mature skeletal cells provide an important cellular source for bone regeneration. It has long been considered that a small number of resident skeletal stem cells are solely responsible for the remarkable regenerative capacity of adult bones. However, recent in vivo lineage‐tracing studies suggest that all stages of skeletal lineage cells, including dormant pre ...
DOI:
10.1002/bies.202000202

7. Theophrastus Bombastus Von Hohenheim (Paracelsus) (1493–1541): The eminent physician and pioneer of toxicology

Author:
Michaleas, Spyros N.; Laios, Konstantinos; Tsoucalas, Gregory; Androutsos, Georges
Source:
Toxicology reports 2021 v.8 pp. 411-414
ISSN:
2214-7500
Subject:
medicine,   etc   ; mercury; toxicology;     Show all 3 Subjects
Abstract:
... Theophrastus Bombastus Von Hohenheim known as Paracelsus was a German-Swiss homo universalis, or Renaissance man, whose interests included medicine, chemistry and toxicology. Characterized as a rebellious and great reformer of established medicine of his era, Paracelsus preferred observing nature, over studying ancient texts to find appropriate treatments for various diseases. He also used unconve ...
DOI:
10.1016/j.toxrep.2021.02.012

8. Supramolecular cancer nanotheranostics

Author:
Zhou, Jiong; Rao, Lang; Yu, Guocan; Cook, Timothy R.; Chen, Xiaoyuan; Huang, Feihe
Source:
Chemical Society reviews 2021 v.50 no.4 pp. 2839-2891
ISSN:
1460-4744
Subject:
medicine; precision medicine,   etc   ; quality of life; survival rate;     Show all 4 Subjects
Abstract:
... Among the many challenges in medicine, the treatment and cure of cancer remains an outstanding goal given the complexity and diversity of the disease. Nanotheranostics, the integration of therapy and diagnosis in nanoformulations, is the next generation of personalized medicine to meet the challenges in precise cancer diagnosis, rational management and effective therapy, aiming to significantly in ...
DOI:
10.1039/d0cs00011f

9. Utilization and expenditures on traditional and herbal medicines in Iran: 2009–2016

Author:
Homaie Rad, Enayatollah; Hajizadeh, Mohammad; Rezaei, Satar; Reihanian, Anita; Ehsani- Chimeh, Elham; Davoudi- Kiakalayeh, Ali
Source:
Journal of herbal medicine 2021 v.25 pp. 100414
ISSN:
2210-8033
Subject:
herbal medicines; traditional medicine,   etc   ; household income; regression analysis; surveys; Iran;     Show all 6 Subjects
Abstract:
... Although some studies have assessed traditional and herbal medicines (THM) in different regions in Iran, no study investigates the determinants of THM in Iran. This study, for the first time, examines factors affecting the utilization and expenditure on THM in Iran over the period between 2009 and 2016.The Iranian Household Income and Expenditures Survey (HIES) (n = 310,617) was used to measure an ...
DOI:
10.1016/j.hermed.2020.100414

10. Use of complementary and alternative medicine among patients with cancer in a sub-Himalayan state in India: An exploratory study

Author:
Pandey, Laxman; Pasricha, Rajesh; Joseph, Deepa; Ahuja, Rachit; Yanthan, Yanpothung; Garg, Pankaj Kumar; Gupta, Manoj
Source:
Journal of Ayurveda and integrative medicine 2021 v.12 no.1 pp. 126-130
ISSN:
0975-9476
Subject:
Ayurvedic medicine; alternative medicine,   etc   ; breast neoplasms; hospitals; questionnaires; yoga; India;     Show all 7 Subjects
Abstract:
... The use of complementary and alternative medicine (CAM) is widespread among cancer patients in India.The present study elucidated usage patterns of CAM and the factors responsible for its adoption among the patients with cancer, and the therapeutic impact of CAM.This was a questionnaire-based study, conducted among patients with cancer in a tertiary care hospital in a sub-Himalayan city. Data were ...
DOI:
10.1016/j.jaim.2021.01.001

11. Comprehensive Review of Biliary Peritonitis

Author:
Thompson, Beverly J; DeClue, Amy; Jaffey, Jared
Source:
Topics in companion animal medicine 2021 pp. 100532
ISSN:
1938-9736
Subject:
medicine; veterinary medicine,   etc   ; dogs; humans; patients; peritonitis; pets;     Show all 7 Subjects
Abstract:
... Biliary peritonitis is a growing concern in the canine patient and a thorough understanding of the disease will lead to better treatment outcomes. This article reviews the human and veterinary literature pertaining to biliary peritonitis including both scientific reviews and original publications. Compared to human medicine, biliary peritonitis can be difficult to diagnose preoperatively. Multiple ...
DOI:
10.1016/j.tcam.2021.100532

12. Response to ‘Methodological flaws on “manual therapy for the pediatric population: a systematic review” by Prevost et al. (2019)’

Author:
Pohlman, Katherine A.; Anderson, Kristian; Carleo, Beth; Gleberzon, Brian
Source:
BMC complementary medicine and therapies 2021 v.21 no.1 pp. 5
ISSN:
2662-7671
Subject:
alternative medicine,   etc   ; patients; systematic review;     Show all 3 Subjects
Abstract:
... Correspondence from Yu et al. identify methodological issues with the systematic review of manual therapy for pediatric manuscript. Like any research study, limitations are important for readers to keep in consideration when reviewing study findings. The primary authors maintain full confidence in the use of the review to provide practicing clinicians with a comprehensive overview of the limited a ...
DOI:
10.1186/s12906-020-03165-2

13. Evolution of organoid technology: Lessons learnt in Co-Culture systems from developmental biology

Author:
Zahmatkesh, Ensieh; Khoshdel-Rad, Niloofar; Mirzaei, Hamed; Shpichka, Anastasia; Timashev, Peter; Mahmoudi, Tokameh; Vosough, Massoud
Source:
Developmental biology 2021 v.475 pp. 37-53
ISSN:
0012-1606
Subject:
medicine,   etc   ; coculture; embryogenesis; organogenesis; organoids;     Show all 5 Subjects
Abstract:
... In recent years, the development of 3D organoids has opened new avenues of investigation into development, physiology, and regenerative medicine. Organoid formation and the process of organogenesis share common developmental pathways; thus, our knowledge of developmental biology can help model the complexity of different organs to refine organoids into a more sophisticated platform. The developmen ...
DOI:
10.1016/j.ydbio.2021.03.001

14. Shining light on cardiac electrophysiology: From detection to intervention, from basic research to translational applications

Author:
Li, Jianyi; Li, Haitao; Rao, Panpan; Luo, Junmiao; Wang, Xi; Wang, Long
Source:
Life sciences 2021 v.274 pp. 119357
ISSN:
0024-3205
Subject:
medicine,   etc   ; electrophysiology; energy; fluorescence; optogenetics;     Show all 5 Subjects
Abstract:
... Cardiac arrhythmias are an important group of cardiovascular diseases, which can occur alone or in association with other cardiovascular diseases. The development of cardiac arrhythmias cannot be separated from changes in cardiac electrophysiology, and the investigation and clarification of cardiac electrophysiological changes are beneficial for the treatment of cardiac arrhythmias. However, elect ...
DOI:
10.1016/j.lfs.2021.119357

15. Assessment of the cutaneous trunci reflex in neurologically healthy cats

Author:
Foss, Kari D; Hague, Devon W; Selmic, Laura
Source:
Journal of feline medicine and surgery 2021 v.23 no.4 pp. 287-292
ISSN:
1532-2750
Subject:
medicine,   etc   ; body condition; cats; surgery;     Show all 4 Subjects
Abstract:
... The aim of this study was to perform the cutaneous trunci reflex (CTR) in neurologically normal cats using two different instruments and determine how body condition score (BCS), body circumference, age, sex and instrument type may affect this reflex. Sixty-five cats without evidence of neurologic disease were prospectively enrolled. Cats were randomly assigned to have the reflex tested first usin ...
DOI:
10.1177/1098612X20944643

16. Association of Veterinary Hematology and Transfusion Medicine (AVHTM) transfusion reaction small animal consensus statement (TRACS). Part 3: Diagnosis and treatment

Author:
Odunayo, Adesola; Nash, Katherine J; Davidow, Elizabeth B.; Blois, Shauna L.; Goy‐Thollot, Isabelle; Harris, Lauren; Humm, Karen; Musulin, Sarah; Sharp, Claire R.; Spada, Eva; Thomason, John; Walton, Jenny; Jane Wardrop, K.
Source:
Journal of veterinary emergency and critical care 2021 v.31 no.2 pp. 189-203
ISSN:
1479-3261
Subject:
medicine,   etc   ; electronic discussion groups; hematology;     Show all 3 Subjects
Abstract:
... OBJECTIVE: To systematically review available evidence to develop guidelines for diagnosis and treatment of transfusion‐associated reactions in dogs and cats. DESIGN: Standardized and systemic evaluation of the literature (identified through Medline via PubMed and Google Scholar searches) was carried out for identified transfusion reaction types in dogs and cats. The available evidence was evaluat ...
DOI:
10.1111/vec.13043

17. Association of Veterinary Hematology and Transfusion Medicine (AVHTM) Transfusion Reaction Small Animal Consensus Statement (TRACS) Part 2: Prevention and monitoring

Author:
Davidow, Elizabeth B.; Blois, Shauna L.; Goy‐Thollot, Isabelle; Harris, Lauren; Humm, Karen; Musulin, Sarah; Nash, Katherine J.; Odunayo, Adesola; Sharp, Claire R.; Spada, Eva; Thomason, John; Walton, Jenny; Wardrop, K. Jane
Source:
Journal of veterinary emergency and critical care 2021 v.31 no.2 pp. 167-188
ISSN:
1479-3261
Subject:
medicine,   etc   ; electronic discussion groups; hematology;     Show all 3 Subjects
Abstract:
... OBJECTIVE: To systematically review available evidence to develop guidelines for the prevention of transfusion reactions and monitoring of transfusion administration in dogs and cats. DESIGN: Evidence evaluation of the literature (identified through Medline searches through Pubmed and Google Scholar searches) was carried out for identified transfusion reaction types in dogs and cats. Evidence was ...
DOI:
10.1111/vec.13045

18. Efficient screening of predictive biomarkers for individual treatment selection

Author:
Sugasawa, Shonosuke; Noma, Hisashi
Source:
Biometrics 2021 v.77 no.1 pp. 249-257
ISSN:
0006-341X
Subject:
precision medicine,   etc   ; biomarkers; breast neoplasms;     Show all 3 Subjects
Abstract:
... The development of molecular diagnostic tools to achieve individualized medicine requires identifying predictive biomarkers associated with subgroups of individuals who might receive beneficial or harmful effects from different available treatments. However, due to the large number of candidate biomarkers in the large‐scale genetic and molecular studies, and complex relationships among clinical ou ...
DOI:
10.1111/biom.13279

19. The Role of Genetic Factors in Endocrine Tissues Development and Its Regulation In Vivo and In Vitro

Author:
Goliusova, D. V.; Klementieva, N. V.; Panova, A. V.; Mokrysheva, N. G.; Kiselev, S. L.
Source:
Russian journal of genetics 2021 v.57 no.3 pp. 273-281
ISSN:
1022-7954
Subject:
medicine,   etc   ; embryogenesis; humans; mice; therapeutics;     Show all 5 Subjects
Abstract:
... Endocrine cells can be fully functional after heterotopic transplantation into mammals, which makes them a promising tool for regenerative medicine. However, to date, cellular therapy for endocrine diseases is limited by the inability to efficiently and stably obtain endocrine cells in vitro. The review focuses on current knowledge of the molecular genetic mechanisms involved in embryonic developm ...
DOI:
10.1134/S102279542103008X

20. Accounting for variation in and overuse of antibiotics among humans

Author:
Blaser, Martin J.; Melby, Melissa K.; Lock, Margaret; Nichter, Mark
Source:
BioEssays 2021 v.43 no.2 pp. e2000163
ISSN:
0265-9247
Subject:
medicine,   etc   ; Internet; antibiotics; caregivers; therapeutics;     Show all 5 Subjects
Abstract:
... Worldwide, antibiotic use is increasing, but many infections against which antibiotics are applied are not even caused by bacteria. Over‐the‐counter and internet sales preclude physician oversight. Regional differences, between and within countries highlight many potential factors influencing antibiotic use. Taking a systems perspective that considers pharmaceutical commodity chains, we examine an ...
DOI:
10.1002/bies.202000163