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1. Rubrofusarin inhibits Aβ aggregation and ameliorates memory loss in an Aβ-induced Alzheimer's disease-like mouse model

Author:
Cho, Eunbi; Cai, Mudan; Kwon, Huiyoung; Jeon, Jieun; Moon, Minho; Jun, Mira; Lee, Young Choon; Yi, Jee Hyun; Ryu, Jong Hoon; Kim, Dong Hyun
Source:
Food and chemical toxicology 2019 v.132 pp. 110698
ISSN:
0278-6915
Subject:
memory disorders,   etc   ; Alzheimer disease; amyloid; animal models; herbal medicines; hippocampus; histopathology; mice; patients; peptides; toxicology;     Show all 11 Subjects
Abstract:
... The misfolding and aggregation of amyloid β (Aβ) peptide is a common histopathologic characteristic in patients with Alzheimer's disease, so is considered to play an critical role. In the present study, we examined the effect of rubrofusarin, an ingredient of Cassiae semen, on Aβ aggregation and memory loss in an AD mouse model. Rubrofusarin inhibited Aβ aggregation in a concentration-dependent ma ...
DOI:
10.1016/j.fct.2019.110698

2. The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer's biomarkers

Author:
Tang, Kim San
Source:
Life sciences 2019 v.233 pp. 116695
ISSN:
0024-3205
Subject:
memory disorders,   etc   ; Alzheimer disease; biomarkers; cognitive disorders; drugs; elderly; memory; models; neurodegenerative diseases; pathogenesis; scopolamine;     Show all 11 Subjects
Abstract:
... Alzheimer's disease (AD) is neurodegenerative disorder that is associated with memory and cognitive decline in the older adults. Scopolamine is commonly used as a behavioral model in studying cognitive disorders including AD. Many studies have also concurrently examined the neurochemical mechanisms underlying the behavioral modifications by scopolamine treatment. Nonetheless, the scopolamine model ...
DOI:
10.1016/j.lfs.2019.116695

3. Regulation of gut microbiota in Alzheimer’s disease mice by silibinin and silymarin and their pharmacological implications

Author:
Shen, Liang; Liu, Lu; Li, Xin-Yu; Ji, Hong-Fang
Source:
Applied microbiology and biotechnology 2019 v.103 no.17 pp. 7141-7149
ISSN:
0175-7598
Subject:
memory disorders,   etc   ; Alzheimer disease; amyloid; brain; genetically modified organisms; histology; intestinal microorganisms; mice; silymarin; therapeutics;     Show all 10 Subjects
Abstract:
... The newly reported associations between Alzheimer’s disease (AD) and gut microbiota indicate the potential of gut microbiota regulation–based therapeutic intervention for AD. Silymarin and its main active component, silibinin, are promising natural agents against AD, while their acting mechanisms remain to be explored. The present study investigated the effects of silibinin and silymarin administr ...
DOI:
10.1007/s00253-019-09950-5

4. Two novel presenilin-1 mutations (I249L and P433S) in early onset Chinese Alzheimer's pedigrees and their functional characterization

Author:
Shen, Luxi; Qin, Wei; Wu, Liyong; Zhou, Aihong; Tang, Yi; Wang, Qi; Jia, Longfei; Jia, Jianping
Source:
Biochemical and biophysical research communications 2019 v.516 no.1 pp. 264-269
ISSN:
0006-291X
Subject:
memory disorders,   etc   ; Alzheimer disease; Lentivirus; amyloid; case studies; genes; mutants; mutation; pathogenesis; pedigree; peptides; screening;     Show all 12 Subjects
Abstract:
... Clinical case study and functional characterization of the disease-associated presenilin-1 (PSEN1) mutations may help reveal the roles of PSEN1 in the pathogenesis of Alzheimer's disease (AD). By mutation screening of PSEN1, presenilin-2, and amyloid precursor protein genes in two Chinese Alzheimer's pedigrees, we identified two novel PSEN1 mutations, I249L and P433S. The two probands presented wi ...
DOI:
10.1016/j.bbrc.2019.05.185

5. Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models

Author:
Orefice, Lauren L.; Mosko, Jacqueline R.; Morency, Danielle T.; Wells, Michael F.; Tasnim, Aniqa; Mozeika, Shawn M.; Ye, Mengchen; Chirila, Anda M.; Emanuel, Alan J.; Rankin, Genelle; Fame, Ryann M.; Lehtinen, Maria K.; Feng, Guoping; Ginty, David D.
Source:
Cell 2019 v.178 no.4 pp. 867-886.e24
ISSN:
0092-8674
Subject:
memory disorders,   etc   ; agonists; animal models; autism; body condition; brain; genes; mice; mutants; neurons; patients; phenotype; therapeutics;     Show all 13 Subjects
Abstract:
... Somatosensory over-reactivity is common among patients with autism spectrum disorders (ASDs) and is hypothesized to contribute to core ASD behaviors. However, effective treatments for sensory over-reactivity and ASDs are lacking. We found distinct somatosensory neuron pathophysiological mechanisms underlie tactile abnormalities in different ASD mouse models and contribute to some ASD-related behav ...
DOI:
10.1016/j.cell.2019.07.024

6. Cognitive training improves the disturbed behavioral architecture of schizophrenia-like rats, “Wisket”

Author:
Horvath, Gyongyi; Liszli, Peter; Kekesi, Gabriella; Büki, Alexandra; Benedek, Gyorgy
Source:
Physiology & behavior 2019 v.201 pp. 70-82
ISSN:
0031-9384
Subject:
memory disorders,   etc   ; animal models; anxiety; cognition; humans; learning; locomotion; motivation; rats; remission; schizophrenia; therapeutics; validity;     Show all 13 Subjects
Abstract:
... Translational schizophrenia research depends on the relevance of animal models supported by reliable tests. Human data suggest that the intensive cognitive training in schizophrenia improves the memory impairments and decreases the chance of acute psychiatric remission. Here we examined the effects of a 10-day long training session in the behavioral architecture of a new schizophrenia-like rat sub ...
DOI:
10.1016/j.physbeh.2018.12.011

7. Pb exposure reduces the expression of SNX6 and Homer1 in offspring rats and PC12 cells

Author:
Pang, Shimin; Li, Yanshu; Chen, Wei; Li, Yaobin; Yang, Meiyuan; Zhao, Lijuan; Shen, Qiwei; Cheng, Nuo; Wang, Ying; Lin, Xuequn; Ma, Jianmin; Wu, Honghao; Zhu, Gaochun
Source:
Toxicology 2019 v.416 pp. 23-29
ISSN:
0300-483X
Subject:
memory disorders,   etc   ; acetates; blood; cognition; dendrites; gene expression; heavy metals; hippocampus; lead; memory; progeny; rats;     Show all 12 Subjects
Abstract:
... Lead (Pb) is a widespread environmental heavy metal toxicant and chronic Pb exposure can have irreversible effects on memory and cognitive function, which is closely related to dendritic spines. Studies have shown that SNX6 and Homer1 can regulate the growth of dendritic spines. We aimed to investigate the effect of Pb exposure on the dendritic spines in hippocampus, the expression of SNX6 and Hom ...
DOI:
10.1016/j.tox.2019.02.002

8. Effect of curcumin on memory impairment: A systematic review

Author:
Sanei, Mozhdeh; Saberi-Demneh, Amir
Source:
Phytomedicine 2019 v.52 pp. 98-106
ISSN:
0944-7113
Subject:
memory disorders,   etc   ; anticonvulsants; anxiety; benzodiazepines; curcumin; databases; memory; models; physicians; rodents; systematic review; therapeutics;     Show all 12 Subjects
Abstract:
... Memory impairment (MI) is one of the most common complaints of people referred to physicians for proper diagnosis. In addition, the prevalence of neurodegenerative lesions like Alzheimer is generally on the increase. Thus far, numerous laboratory studies have been conducted to evaluate the effect of curcumin on the improvement of MI.The aim of this study was to review the efficacy of curcumin on M ...
DOI:
10.1016/j.phymed.2018.06.016

9. Do elite breath-hold divers suffer from mild short-term memory impairments?

Author:
Billaut, François; Gueit, Patrice; Faure, Sylvane; Costalat, Guillaume; Lemaître, Frédéric
Source:
Applied physiology, nutrition and metabolism 2018 v.43 no.3 pp. 247-251
ISSN:
1715-5320
Subject:
memory disorders,   etc   ; apnea; consciousness; education; hypoxia; memory; men; sports; students;     Show all 9 Subjects
Abstract:
... Repeated apneas are associated with severe hypoxemia that may ultimately lead to loss of consciousness in some breath-hold divers. Despite increasing number of practitioners, the relationship between apnea-induced hypoxia and neurocognitive functions is still poorly understood in the sport of free diving. To shed light onto this phenomenon, we examined the impact of long-term breath-hold diving tr ...
DOI:
10.1139/apnm-2017-0245

10. Ginkgo biloba treatments reverse the impairment of conditioned suppression acquisition induced by GluN2B-NMDA and 5-HT1A receptor blockade: Modulatory effects of the circuitry of the dorsal hippocampal formation

Author:
Zamberlam, Cláudia R.; Tilger, Myrcea A.S.; Moraes, Laís; Cerutti, Janete M.; Cerutti, Suzete M.
Source:
Physiology & behavior 2019 v.209 pp. 112534
ISSN:
0031-9384
Subject:
memory disorders,   etc   ; Ginkgo biloba; agonists; antagonists; astrocytes; cognition; diazepam; fearfulness; gamma-aminobutyric acid; hippocampus; memory; messenger RNA; rats; receptors; serotonin;     Show all 15 Subjects
Abstract:
... To improve our understanding of the effects of standardized extract of Ginkgo biloba (EGb) as a cognitive enhancer, we investigated the conditioned lick suppression-induced expression (mRNA and protein) of the GluN2B-containing N-methyl-D-aspartic acid receptor (GluN2B-NMDAR), serotonin (5-HT) 1A receptor (5-HT1AR), gamma-aminobutyric acid type A receptor (GABAAR) and glial fibrillary acidic prote ...
DOI:
10.1016/j.physbeh.2019.04.023

11. LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

Author:
Heckmann, Bradlee L.; Teubner, Brett J.W.; Tummers, Bart; Boada-Romero, Emilio; Harris, Lacie; Yang, Mao; Guy, Clifford S.; Zakharenko, Stanislav S.; Green, Douglas R.
Source:
Cell 2019 v.178 no.3 pp. 536-551.e14
ISSN:
0092-8674
Subject:
memory disorders,   etc   ; Alzheimer disease; animal models; autophagy; cytokines; endosomes; hippocampus; inflammation; mice; neurodegenerative diseases; neuroglia; neurons; neurotoxicity; protective effect; proteins;     Show all 15 Subjects
Abstract:
... The expression of some proteins in the autophagy pathway declines with age, which may impact neurodegeneration in diseases, including Alzheimer’s Disease. We have identified a novel non-canonical function of several autophagy proteins in the conjugation of LC3 to Rab5+, clathrin+ endosomes containing β-amyloid in a process of LC3-associated endocytosis (LANDO). We found that LANDO in microglia is ...
DOI:
10.1016/j.cell.2019.05.056

12. Extracellular Vesicles from Mesenchymal Stem Cells Exert Pleiotropic Effects on Amyloid‐β, Inflammation, and Regeneration: A Spark of Hope for Alzheimer's Disease from Tiny Structures?

Author:
Elia, Chiara A.; Losurdo, Morris; Malosio, Maria L.; Coco, Silvia
Source:
BioEssays 2019 v.41 no.4 pp. e1800199
ISSN:
0265-9247
Subject:
memory disorders,   etc   ; Alzheimer disease; amyloid; cell death; enzymes; inflammation; lipids; mesenchymal stromal cells; microRNA; neurons; pleiotropy; therapeutics;     Show all 12 Subjects
Abstract:
... No cure yet exists for devastating Alzheimer's disease (AD), despite many years and humongous efforts to find efficacious pharmacological treatments. So far, neither designing drugs to disaggregate amyloid plaques nor tackling solely inflammation turned out to be decisive. Mesenchymal stem cells (MSCs) and, in particular, extracellular vesicles (EVs) originating from them could be proposed as an a ...
DOI:
10.1002/bies.201800199

13. Comparative studies of DHA-enriched phosphatidylcholine and recombination of DHA-ethyl ester with egg phosphatidylcholine on ameliorating memory and cognitive deficiency in SAMP8 mice

Author:
Wang, Cheng-Cheng; Guo, Ying; Zhou, Miao-Miao; Xue, Chang-Hu; Chang, Yao-Guang; Zhang, Tian-Tian; Wang, Yu-Ming
Source:
Food & function 2019 v.10 no.2 pp. 938-950
ISSN:
2042-650X
Subject:
memory disorders,   etc   ; apoptosis; bioactive compounds; cognition; docosahexaenoic acid; eggs; fish oils; foods; memory; mice; neurodegenerative diseases; neurotrophins; phosphatidylcholines;     Show all 13 Subjects
Abstract:
... Docosahexaenoic acid-enriched phospholipids (DHA-PLs) are important bioactive components from marine foods, and are barely obtained by people living inland due to limited sources of commercial DHA-PLs compared to commercial DHA-TG and DHA-EE fish oil. Therefore, it is of significance to develop substitutions of DHA-PLs. In the present study, we comparatively investigated the effects of DHA-phospha ...
DOI:
10.1039/c8fo01822g

14. Extinction and recovery of an avoidance memory impaired by scopolamine

Author:
Navarro, N.M.; Krawczyk, M.C.; Boccia, M.M.; Blake, M.G.
Source:
Physiology & behavior 2017 v.171 pp. 192-198
ISSN:
0031-9384
Subject:
memory disorders,   etc   ; memory; mice; protocols; scopolamine;     Show all 5 Subjects
Abstract:
... Pre-training administration of scopolamine (SCP) resembles situations of cholinergic dysfunction, leading to memory impairment of mice trained in an inhibitory avoidance task. We suggest here that SCP does not impair memory formation, but acquisition is affected in a way that reduces the strength of the stored memory, thus making this memory less able to control behavior when tested. Hence, a memo ...
DOI:
10.1016/j.physbeh.2016.12.042

15. Leaf extracts from Dendropanax morbifera Léveille mitigate mercury-induced reduction of spatial memory, as well as cell proliferation, and neuroblast differentiation in rat dentate gyrus

Author:
Kim, Woosuk; Yoo, Dae Young; Jung, Hyo Young; Kim, Jong Whi; Hahn, Kyu Ri; Kwon, Hyun Jung; Yoo, Miyoung; Lee, Sanghee; Nam, Sung Min; Yoon, Yeo Sung; Kim, Dae Won; Hwang, In Koo
Source:
BMC complementary and alternative medicine 2019 v.19 no.1 pp. 94
ISSN:
1472-6882
Subject:
memory disorders,   etc   ; Dendropanax morbifer; acetylcholinesterase; alternative medicine; brain; cell proliferation; functional foods; immunohistochemistry; leaf extracts; memory; methylmercury compounds; neurons; rats; staining; toxicity;     Show all 15 Subjects
Abstract:
... BACKGROUND: The brain is susceptible to methylmercury toxicity, which causes irreversible damage to neurons and glia and the leaf extract Dendropanax morbifera Léveille (DML) has various biological functions in the nervous system. In this study, we examined the effects of DML on mercury-induced proliferating cells and differentiated neuroblasts. METHODS: Dimethylmercury (5 μg/kg) and galantamine ( ...
DOI:
10.1186/s12906-019-2508-6

16. Anxiolytic impact of Apelin-13 in a rat model of Alzheimer's disease: Involvement of glucocorticoid receptor and FKBP5

Author:
Aminyavari, Samaneh; Zahmatkesh, Maryam; Khodagholi, Fariba; Sanati, Mehdi
Source:
Peptides 2019 v.118 pp. 170102
ISSN:
0196-9781
Subject:
memory disorders,   etc   ; Alzheimer disease; amyloid; animal models; anxiety; binding proteins; cognitive disorders; elevated plus-maze test; glucocorticoid receptors; neuropeptides; neuroprotective effect; pathophysiology; rodents; tranquilizers;     Show all 14 Subjects
Abstract:
... Apelin-13 is known to be one of the predominant neuropeptides with marked protective role in circuits involved in mood disturbances. The most putative hypothesis in pathophysiology of Alzheimer's disease (AD) is Amyloid beta (Aβ) aggregation which interrupt proper function of hypothalamic–pituitary–adrenal (HPA) axis and are associated with anxiety. Here, we assessed the potential anxiolytic effec ...
DOI:
10.1016/j.peptides.2019.170102

17. Long-term iron exposure causes widespread molecular alterations associated with memory impairment in mice

Author:
Wang, Xian; Zhang, Jiafei; Zhou, Li; Xu, Benhong; Ren, Xiaohu; He, Kaiwu; Nie, Lulin; Li, Xiao; Liu, Jianjun; Yang, Xifei; Yuan, Jing
Source:
Food and chemical toxicology 2019 v.130 pp. 242-252
ISSN:
0278-6915
Subject:
memory disorders,   etc   ; adenosine diphosphate; adenosine triphosphate; bioinformatics; cognition; cognitive disorders; cytoskeletal proteins; cytoskeleton; enzymes; gene expression regulation; iron; learning; membrane proteins; mice; mitochondria; neurotoxicity; polypeptides; proteomics; toxicology; tubulin;     Show all 20 Subjects
Abstract:
... Limited literature available indicates the neurotoxic effects of excessive iron, however, a deep understanding of iron neurotoxicity needs to be developed. In this study, we evaluated the toxic effects of excessive iron on learning and cognitive function in long-term iron exposure (oral, 10 mg/L, 6 months) of mice by behavioral tests including novel object recognition test, step-down passive avoid ...
DOI:
10.1016/j.fct.2019.05.038

18. An organic electrochemical transistor integrated with a molecularly selective isoporous membrane for amyloid-β detection

Author:
Wustoni, Shofarul; Wang, Shaofei; Alvarez, Juan R.; Castillo, Tania H.; Nunes, Suzana P.; Inal, Sahika
Source:
Biosensors & bioelectronics 2019
ISSN:
0956-5663
Subject:
memory disorders,   etc   ; Alzheimer disease; biosensors; blood serum; brain; cognition; early diagnosis; electrochemistry; human resources; humans; ions; neurodegenerative diseases; peptides; point-of-care systems; porosity; transistors;     Show all 16 Subjects
Abstract:
... Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with severe memory loss and impaired cognitive skills. A common pathological change found in AD-affected brains is the accumulation of a peptide named amyloid-β (Aβ) that can form plaques. Aβ aggregates are visible to structural scanning tools; however, these bulky and expensive instruments are accessible to trained per ...
DOI:
10.1016/j.bios.2019.111561

19. New barrigenol-type triterpenoids with anti-Alzheimer’s disease activity from Koelreuteria paniculata Laxm

Author:
Lu, Xiao; Sun, LiangDi; Zhang, YaXin; Li, Wei
Source:
Journal of functional foods 2019 pp. 103459
ISSN:
1756-4646
Subject:
memory disorders,   etc   ; Koelreuteria paniculata; computer simulation; glycogen (starch) synthase; learning; mice; okadaic acid; ornamental trees; phosphoprotein phosphatase; seeds; spectroscopy; tau-protein kinase; triterpenoids;     Show all 13 Subjects
Abstract:
... Koelreuteria paniculata Laxm. has long been cultivated as a traditional ornamental tree in the world, and is developed as a source of natural green food. In this work, five new barrigenol-type triterpenoids, compounds 1-5, were isolated from the seeds of Koelreuteria paniculata Laxm. and elucidated by right of several spectroscopic methods. We studied the impacts of compounds 1-5 on learning and m ...
DOI:
10.1016/j.jff.2019.103459

20. Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR

Author:
Wang, Jing; Chen, Yabing; Zhang, Changliang; Xiang, Zou; Ding, Jie; Han, Xiaodong
Source:
Journal of hazardous materials 2019 v.373 pp. 504-518
ISSN:
0304-3894
Subject:
memory disorders,   etc   ; Alzheimer disease; apoptosis; chronic exposure; cortex; drinking water; hippocampus; mice; microcystin-LR; neurons; neurotoxicity; phosphorylation; public health; signal transduction;     Show all 14 Subjects
Abstract:
... Previous studies have demonstrated that toxins produced by toxic cyanobacterial blooms are hazardous materials. Although microcystin-LR (MC-LR) has been revealed to inflict damage to the brain, the mechanisms underlying its neurotoxicity as a result of chronic exposure to MC-LR are not fully described. In this study, the mice were exposed to MC-LR dissolved in drinking water at doses of 1, 7.5, 15 ...
DOI:
10.1016/j.jhazmat.2019.03.106