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1. Gastrodin as a multi-target protective compound reverses learning memory deficits and AD-like pathology in APP/PS1 transgenic mice

Author:
Zeng, Yue-Qin; Gu, Juan-Hua; Chen, Liang; Zhang, Tao-Tao; Zhou, Xin-Fu
Source:
Journal of functional foods 2021 v.77 pp. 104324
ISSN:
1756-4646
Subject:
memory disorders,   etc   ; Alzheimer disease; bioactive compounds; cognitive disorders; cytokines; diet; enzymes; functional foods; genetically modified organisms; glucosides; learning; mice; neurodegenerative diseases; neuroglia; neurotoxicity; oral administration; oxidative stress; people; phenolic compounds; rhizomes;     Show all 20 Subjects
Abstract:
... Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. Evidence suggests that people can benefit from consumption of diets rich in plant phenolics because they can attenuate AD symptoms. The phenolic glucoside gastrodin is the main bioactive compound of Rhizoma Gastrodiae and is widely used for treating various neurological disorders. In this study, we assess whether long term oral ...
DOI:
10.1016/j.jff.2020.104324

2. AGLPM and QMDDQ peptides exert a synergistic action on memory improvement against scopolamine-induced amnesiac mice

Author:
Wu, Dan; Xu, Xiaomeng; Sun, Na; Li, Dongmei; Zhu, Beiwei; Lin, Songyi
Source:
Food & function 2020 v.11 no.12 pp. 10925-10935
ISSN:
2042-650X
Subject:
memory disorders,   etc   ; acetylcholine; acetylcholinesterase; cells; hippocampus; memory; mice; neurons; peptides; synergism; testing;     Show all 11 Subjects
Abstract:
... This study aimed to explore the synergistic action of pentapeptides Gln-Met-Asp-Asp-Gln (QMDDQ) and Ala-Gly-Leu-Pro-Met (AGLPM) on memory improvement against scopolamine-induced impairment in mice compared to those of either peptide alone. In behavioral tests, the codelivery of QMDDQ and AGLPM was superior to the individual supplements of either peptide alone not only in enhancing the memory abili ...
DOI:
10.1039/d0fo02570d

3. Emotion regulation difficulties and impaired working memory interact to predict boredom emotional eating

Author:
Ferrell, Emily L.; Watford, Tanya S.; Braden, Abby
Source:
Appetite 2020 v.144 pp. 104450
ISSN:
0195-6663
Subject:
memory disorders,   etc   ; anxiety; binging; cognition; college students; memory; regression analysis; risk factors; standard deviation; weight gain;     Show all 10 Subjects
Abstract:
... Emotional eating (EE), or eating in response to emotions, is related to depression, binge eating, and weight gain. Emotion regulation difficulties are a risk factor for EE. Working memory deficits may also be a risk factor for EE, as working memory is an important cognitive factor in emotion regulation. The current study is a secondary analysis that examined whether working memory moderated the re ...
DOI:
10.1016/j.appet.2019.104450

4. Antidementia effects, metabolic profiles and pharmacokinetics of GJ-4, a crocin-rich botanical candidate from Gardeniae fructus

Author:
Pang, Qianqian; Zhang, Weiyang; Li, Chenyang; Li, Haibo; Zhang, Yu; Li, Lin; Zang, Caixia; Yao, Xinsheng; Zhang, Dan; Yu, Yang
Source:
Food & function 2020 v.11 no.10 pp. 8825-8836
ISSN:
2042-650X
Subject:
memory disorders,   etc   ; Gardenia; carotenoids; dementia; esters; fruits; hydrophilicity; learning; liquids; models; neuroprotective effect; oral administration; pharmacokinetics; saffron; spectroscopy; stigma;     Show all 16 Subjects
Abstract:
... Crocins, a series of hydrophilic carotenoids that are either mono- or di-glycosyl polyene esters of crocetin extracted from dried saffron stigma or fruits of gardenia, are attracting much attention due to their wide range of pharmacological effects. In our previous study, GJ-4, a mixture of crocin analogues, was obtained and derived from gardenia fruits. Mainly 18 crocin analogues were identified ...
DOI:
10.1039/d0fo01678k

5. Sub‐chronic administration of benzo[a]pyrene disrupts hippocampal long‐term potentiation via inhibiting CaMK II/PKC/PKA‐ERK‐CREB signaling in rats

Author:
Lyu, Yi; Ren, Xue‐Ke; Zhang, Hui‐Fang; Tian, Feng‐Jie; Mu, Jian‐Bing; Zheng, Jin‐Ping
Source:
Environmental toxicology 2020 v.35 no.9 pp. 961-970
ISSN:
1520-4081
Subject:
memory disorders,   etc   ; ecotoxicology; glutamate receptors; hippocampus; inactivation; ion channels; males; memory; neurons; neurotoxicity; pollutants; protein phosphorylation; rats; signal transduction;     Show all 14 Subjects
Abstract:
... Benzo[a]pyrene (B[a]P) is recognized as a neurotoxic pollutant to mammals, which could impair learning and memory function. Although there is some evidence to suggest that N‐methyl‐d‐aspartate receptor (NMDAR), a glutamate receptor and ion channel protein in nerve cells, is involved into the B[a]P induced neurotoxicity, the exact molecular mechanisms remain to be elucidated, particularly the effec ...
DOI:
10.1002/tox.22932

6. The treatment of Goji berry (Lycium barbarum) improves the neuroplasticity of the prefrontal cortex and hippocampus in aged rats

Author:
Ruíz-Salinas, Ana Karen; Vázquez-Roque, Rubén A; Díaz, Alfonso; Pulido, Guadalupe; Treviño, Samuel; Floran, Benjamín; Flores, Gonzalo
Source:
The Journal of nutritional biochemistry 2020 v.83 pp. 108416
ISSN:
0955-2863
Subject:
memory disorders,   etc   ; Lycium barbarum; antioxidants; caspase-3; hippocampus; memory; neurons; neuroplasticity; neuroprotective effect; prefrontal cortex; rats; therapeutics;     Show all 12 Subjects
Abstract:
... The main characteristic of brain aging is an exacerbated inflammatory and oxidative response that affects dendritic morphology and the function of the neurons of the prefrontal cortex (PFC) and the hippocampus. This consequently causes memory loss. Recently, the use of the Goji berry (Lycium barbarum) as an antioxidant extract has provided neuroprotection and neuroplasticity, however, its therapeu ...
DOI:
10.1016/j.jnutbio.2020.108416

7. Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats

Author:
Sirichoat, Apiwat; Suwannakot, Kornrawee; Chaisawang, Pornthip; Pannangrong, Wanassanun; Aranarochana, Anusara; Wigmore, Peter; Welbat, Jariya Umka
Source:
Life sciences 2020 v.248 pp. 117468
ISSN:
0024-3205
Subject:
memory disorders,   etc   ; adults; animal models; cognitive disorders; fluorouracil; intravenous injection; males; melatonin; memory; neonates; neurogenesis; neurons; neuroprotective effect; patients; photoperiod;     Show all 15 Subjects
Abstract:
... Treatment with 5-fluorouracil (5-FU) can cause impairment to adult hippocampal neurogenesis, resulting in cognitive deficits. As melatonin has been shown to enhance memory and hippocampal neurogenesis in animal models, this research investigated the neuroprotective effects of melatonin against spatial memory and hippocampal neurogenesis impairment in 5-fluorouracil (5-FU)-treated rats.Four-Five we ...
DOI:
10.1016/j.lfs.2020.117468

8. The degraded polysaccharide from Pyropia haitanensis represses amyloid beta peptide-induced neurotoxicity and memory in vivo

Author:
Zhang, Zhongshan; Wang, Xiaomei; Pan, Yongliang; Wang, Guozhi; Mao, Genxiang
Source:
International journal of biological macromolecules 2020 v.146 pp. 725-729
ISSN:
0141-8130
Subject:
memory disorders,   etc   ; Alzheimer disease; Pyropia; acetylcholine; acetylcholinesterase; amyloid; antioxidants; choline acetyltransferase; colorimetry; enzyme activity; memory; mice; neurotoxicity; peptides; polysaccharides;     Show all 15 Subjects
Abstract:
... An antioxidant polysaccharide, porphyran, from red algae Pyropia haitanensis, is introduced as a protective agent against neurotoxicity-induced amyloid β peptide (Aβ) of Alzheimer’s disease (AD) mice. Then the activity of acetylcholinesterase (AChE) and choline acetyltransferase (CHAT) in the cortical and hippocampal tissue were examined by colorimetric method. Results showed that porphyran signif ...
DOI:
10.1016/j.ijbiomac.2019.09.243

9. Wolfberry extracts inhibit Aβ1-42 aggregation and rescue memory loss of AD drosophila

Author:
Li, Cai-Hong; Yang, Jun-Li
Source:
Food science and human wellness 2020 v.9 no.1 pp. 64-70
ISSN:
2213-4530
Subject:
memory disorders,   etc   ; Alzheimer disease; Drosophila; Lycium; antioxidant activity; boiling; fruit extracts; genetically modified organisms; models; polysaccharides; China;     Show all 11 Subjects
Abstract:
... This study is to investigate the potential of wolfberry water extracts for the treatment of Alzheimer’s disease (AD) and the relationship between their anti-AD property and the geographic locations in China. Total extracts of all wolfberry samples showed the potent to decrease self-induced Aβ₁₋₄₂ aggregation and Cu²⁺-induced Aβ₁₋₄₂ aggregation and the antioxidant capacity as well as the bioactivit ...
DOI:
10.1016/j.fshw.2019.12.007

10. Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons

Author:
Zhang, Changliang; Wang, Jing; Zhu, Jinling; Chen, Yabing; Han, Xiaodong
Source:
The Science of the total environment 2020 v.703 pp. 134702
ISSN:
0048-9697
Subject:
memory disorders,   etc   ; apoptosis; blood-brain barrier; calcium; chronic exposure; enzymes; learning; mice; microcystin-LR; mitochondria; neurons; neurotoxicity; oxidative stress; phosphorylation;     Show all 14 Subjects
Abstract:
... Microcystin–leucine–arginine (MC-LR) can cross the blood–brain barrier (BBB) and demonstrate potent acute hippocampal neurotoxicity. Chronic exposure to MC-LR has been confirmed to cause learning and memory deficits in mice, but the potential molecular mechanism of MC-LR-caused neurotoxicity is still unclear. In this research, we observed that MC-LR induced oxidative stress, mitochondrial fission ...
DOI:
10.1016/j.scitotenv.2019.134702

11. Enhanced in Vivo Blood–Brain Barrier Penetration by Circular Tau–Transferrin Receptor Bifunctional Aptamer for Tauopathy Therapy

Author:
Li, Xiaowei; Yang, Yu; Zhao, Hengzhi; Zhu, Tian; Yang, Zhihui; Xu, Haiyan; Fu, Yueqiang; Lin, Fan; Pan, Xiaoshu; Li, Long; Cui, Cheng; Hong, Min; Yang, Lu; Wang, Kevin K.; Tan, Weihong
Source:
Journal of the American Chemical Society 2020 v.142 no.8 pp. 3862-3872
ISSN:
1520-5126
Subject:
memory disorders,   etc   ; blood plasma; blood-brain barrier; brain; brain damage; cognition; endothelial cells; oligonucleotides; phosphorylation; physiological transport; therapeutics; transferrin receptors;     Show all 12 Subjects
Abstract:
... The lack of blood–brain barrier (BBB) penetrating ability has hindered the delivery of many therapeutic agents for tauopathy treatment. In this study, we report the synthesis of a circular bifunctional aptamer to enhance the in vivo BBB penetration for better tauopathy therapy. The circular aptamer consists of one reported transferrin receptor (TfR) aptamer to facilitate TfR-aptamer recognition-in ...
DOI:
10.1021/jacs.9b11490

12. N,N-dimethylglycine prevents toluene-induced impairment in recognition memory and synaptic plasticity in mice

Author:
Hsieh, Chung-Pin; Chen, Hao; Chan, Ming-Huan; Chen, Linyi; Chen, Hwei-Hsien
Source:
Toxicology 2020 v.446 pp. 152613
ISSN:
0300-483X
Subject:
memory disorders,   etc   ; agonists; antagonists; binding sites; cognition; dose response; glycine (amino acid); males; memory; mice; monitoring; neuroplasticity; poisoning; protective effect; risk; synaptic transmission; toluene;     Show all 17 Subjects
Abstract:
... Toluene intoxication produces deleterious effects on cognitive function, which has been associated with the inhibition of N-methyl-d-aspartate receptor (NMDAR). The present study determined whether N,N-dimethylglycine (DMG), a nutrient supplement and a partial agonist for NMDAR glycine binding site, could counteract recognition memory deficits and hippocampal synaptic dysfunction after acute tolue ...
DOI:
10.1016/j.tox.2020.152613

13. Standardized Bacopa monnieri Extract Ameliorates Learning and Memory Impairments through Synaptic Protein, Neurogranin, Pro-and Mature BDNF Signaling, and HPA Axis in Prenatally Stressed Rat Offspring

Author:
Sivasangari, Karunanithi; Rajan, Koilmani Emmanuvel
Source:
Antioxidants 2020 v.9 no.12
ISSN:
2076-3921
Subject:
memory disorders,   etc   ; Bacopa monnieri; antioxidant activity; antioxidants; apoptosis; brain; cages; corticosterone; corticotropin; density; glucocorticoid receptors; memory; neurodevelopment; phosphorylation; pretreatment; progeny; protein kinases; rats;     Show all 18 Subjects
Abstract:
... Prenatal stress (PNS) influences offspring neurodevelopment, inducing anxiety-like behavior and memory deficits. We investigated whether pretreatment of Bacopa monnieri extract (CDRI-08/BME) ameliorates PNS-induced changes in signaling molecules, and changes in the behavior of Wistar rat offspring. Pregnant rats were randomly assigned into control (CON)/prenatal stress (PNS)/PNS and exposed to BME ...
DOI:
10.3390/antiox9121229

14. Increased behavioral and neuronal responses to a hallucinogenic drug after adolescent toluene exposure in mice: Effects of antipsychotic treatment

Author:
Lee, Mei-Yi; Lin, Bih-Fen; Chan, Ming-Huan; Chen, Hwei-Hsien
Source:
Toxicology 2020 v.445 pp. 152602
ISSN:
0300-483X
Subject:
memory disorders,   etc   ; adolescence; adolescents; adulthood; agonists; animal models; antagonism; antipsychotics; cognitive disorders; electrophysiology; haloperidol; head; hypersensitivity; males; mice; neurons; prefrontal cortex; receptors; social behavior; toluene;     Show all 20 Subjects
Abstract:
... Toluene has been characterized as a non-classical hallucinogen drug through activation of 5-HT₂A receptors and antagonism of NMDA receptors. It remains unclear whether psychotic symptoms after long-term and intense toluene exposure are associated with abnormalities in 5-HT₂A receptor function. The present study examined whether the responses to a hallucinogenic 5-HT₂A receptor agonist 2,5-dimethox ...
DOI:
10.1016/j.tox.2020.152602

15. Jiawei Shengmai San herbal formula ameliorates diabetic associate cognitive decline by modulating AKT and CREB in rats

Author:
Ahmed, Ayaz; Zeng, Guirong; Azhar, Mudassar; Lin, Haiying; Zhang, Mijia; Wang, Fengzhong; Zhang, Hong; Jiang, Dejian; Yang, Sijin; Farooq, Ahsana Dar; Choudhary, Muhammad Iqbal; Liu, Xinmin; Wang, Qiong
Source:
Phytotherapy research 2020 v.34 no.12 pp. 3249-3261
ISSN:
0951-418X
Subject:
memory disorders,   etc   ; Ophiopogon japonicus; Panax ginseng; Schisandra chinensis; Western blotting; blood glucose; brain; cognitive disorders; diabetes; histopathology; memory; phytotherapy; protein synthesis; proteins; rats; research; streptozotocin; testing;     Show all 18 Subjects
Abstract:
... Memory loss is a complication of diabetes which requires new approaches to its treatment. Shengmai San (SMS) is a famous traditional Chinese formula containing Panax ginseng, Ophiopogon japonicas, and Schisandra chinensis, whereas Radix puerariae has many reported pharmacological uses. In this study the combination, as Jiawei SMS (J‐SMS) was screened for its ability to reverse diabetes‐associated ...
DOI:
10.1002/ptr.6773

16. ADSCs-derived extracellular vesicles alleviate neuronal damage, promote neurogenesis and rescue memory loss in mice with Alzheimer's disease

Author:
Ma, Xinyi; Huang, Meng; Zheng, Mengna; Dai, Chengxiang; Song, Qingxiang; Zhang, Qian; Li, Qian; Gu, Xiao; Chen, Huan; Jiang, Gan; Yu, Ye; Liu, Xuesong; Li, Suke; Wang, Gang; Chen, Hongzhuan; Lu, Liangjing; Gao, Xiaoling
Source:
Journal of controlled release 2020 v.327 pp. 688-702
ISSN:
0168-3659
Subject:
memory disorders,   etc   ; Alzheimer disease; brain; cognition; genes; intranasal administration; mesenchymal stromal cells; mice; neonates; neurogenesis; neuroglia; neurons; neuroprotective effect; pathogenesis; proteins; proteomics; sequence analysis; toxicity; transgenic animals;     Show all 19 Subjects
Abstract:
... Despite the various mechanisms that involved in the pathogenesis of Alzheimer's disease (AD), neuronal damage and synaptic dysfunction are the key events leading to cognition impairment. Therefore, neuroprotection and neurogenesis would provide essential alternatives to the rescue of AD cognitive function. Here we demonstrated that extracellular vesicles secreted from adipose-derived mesenchymal s ...
DOI:
10.1016/j.jconrel.2020.09.019

17. Hydroalcoholic extract from Abelmoschus manihot (Linn.) Medicus flower reverses sleep deprivation-evoked learning and memory deficit

Author:
Zhou, Hai-rui; Wu, Jing-ru; Bei, Lei; Wang, Bai-xin; Xu, Hui; Wang, Jing-tao; Ma, Shu-xia
Source:
Food & function 2020 v.11 no.10 pp. 8978-8986
ISSN:
2042-650X
Subject:
memory disorders,   etc   ; Abelmoschus manihot; antioxidant activity; antioxidant enzymes; brain; cognition; flowers; glutamate receptors; malondialdehyde; memory; mice; models; neuroprotective effect; oxidative stress; protein synthesis; sleep deprivation; tissues; tyrosine;     Show all 18 Subjects
Abstract:
... Previous researches have indicated that sleep plays a vital role in cognitive functions. Sleep deprivation (SD) causes learning and memory damage, which is associated with oxidative stress. This study was performed to investigate the neuroprotective effects of an extract of Abelmoschus manihot flower (EAM) against memory deficit induced by SD in mice. The SD model was evoked by multiple platform m ...
DOI:
10.1039/d0fo02158j

18. Mogrol attenuates lipopolysaccharide (LPS)-induced memory impairment and neuroinflammatory responses in mice

Author:
Wang, Hui; Meng, Guo-Liang; Zhang, Chun-Teng; Wang, Hao; Hu, Mei; Long, Yan; Hong, Hao; Tang, Su-Su
Source:
Journal of Asian natural products research 2020 v.22 no.9 pp. 864-878
ISSN:
1477-2213
Subject:
memory disorders,   etc   ; Siraitia grosvenorii; Western blotting; frontal lobe; hippocampus; immunohistochemistry; ingredients; interleukin-1beta; interleukin-6; lipopolysaccharides; mice; oral administration; transcription factor NF-kappa B; tumor necrosis factor-alpha;     Show all 14 Subjects
Abstract:
... This study aimed to evaluate whether mogrol, a main bioactive ingredient of Siraitia grosvenorii, could attenuate LPS-induced memory impairment in mice. The behavioral tests and immunohistochemical analysis and Western blot were performed. The present results showed that oral administration of mogrol (20, 40, 80 mg/kg) significantly improved LPS-induced memory impairment in mice. The results also ...
DOI:
10.1080/10286020.2019.1642878

19. Resveratrol ameliorates disorders of mitochondrial biogenesis and mitophagy in rats continuously exposed to benzo(a)pyrene from embryonic development through adolescence

Author:
Chen, Kai-Ge; Kang, Run-Run; Sun, Qian; Liu, Chang; Ma, Zhuo; Liu, Kuan; Deng, Yu; Liu, Wei; Xu, Bin
Source:
Toxicology 2020 v.442 pp. 152532
ISSN:
0300-483X
Subject:
memory disorders,   etc   ; adolescence; adults; benzo(a)pyrene; biogenesis; children; embryogenesis; hippocampus; homeostasis; laboratory animals; memory; mitochondria; mitophagy; neurodevelopment; neurons; neurotoxicity; proteins; rats; resveratrol; signal transduction;     Show all 20 Subjects
Abstract:
... Exposure to benzo(a)pyrene (BaP) is associated with poor neurodevelopment in children and memory impairment in adults. Previous research has demonstrated that mitochondrial damage plays an important role in BaP-induced neurotoxicity. Of interest, increasing evidence has suggested that resveratrol (RSV) can alleviate nerve cell damage, however the exact mechanisms of biological activity in mitochon ...
DOI:
10.1016/j.tox.2020.152532

20. MicroRNAs Modulate the Pathogenesis of Alzheimer’s Disease: An In Silico Analysis in the Human Brain

Author:
Gugliandolo, Agnese; Chiricosta, Luigi; Boccardi, Virginia; Mecocci, Patrizia; Bramanti, Placido; Mazzon, Emanuela
Source:
Genes 2020 v.11 no.9
ISSN:
2073-4425
Subject:
memory disorders,   etc   ; Alzheimer disease; amyloid; brain; cognition; computer simulation; gene expression regulation; genes; humans; messenger RNA; microRNA; neurodegenerative diseases; neurons; pathogenesis; patients; proteinases; translation (genetics);     Show all 17 Subjects
Abstract:
... MicroRNAs (miRNAs) are small RNAs involved in the post-transcriptional regulation of their target genes, causing a decrease in protein translation from the mRNA. Different miRNAs are found in the nervous system, where they are involved in its physiological functions, but altered miRNAs expression was also reported in neurodegenerative disorders, including Alzheimer’s disease (AD). AD is characteri ...
DOI:
10.3390/genes11090983