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- Author:
- Zeng, Yue-Qin; Gu, Juan-Hua; Chen, Liang; Zhang, Tao-Tao; Zhou, Xin-Fu
- Source:
- Journal of functional foods 2021 v.77 pp. 104324
- ISSN:
- 1756-4646
- Subject:
- memory disorders, etc ; Alzheimer disease; bioactive compounds; cognitive disorders; cytokines; diet; enzymes; functional foods; genetically modified organisms; glucosides; learning; mice; neurodegenerative diseases; neuroglia; neurotoxicity; oral administration; oxidative stress; people; phenolic compounds; rhizomes; Show all 20 Subjects
- Abstract:
- ... Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. Evidence suggests that people can benefit from consumption of diets rich in plant phenolics because they can attenuate AD symptoms. The phenolic glucoside gastrodin is the main bioactive compound of Rhizoma Gastrodiae and is widely used for treating various neurological disorders. In this study, we assess whether long term oral ...
- DOI:
- 10.1016/j.jff.2020.104324
-
https://dx.doi.org/10.1016/j.jff.2020.104324
- Author:
- Wu, Dan; Xu, Xiaomeng; Sun, Na; Li, Dongmei; Zhu, Beiwei; Lin, Songyi
- Source:
- Food & function 2020 v.11 no.12 pp. 10925-10935
- ISSN:
- 2042-650X
- Subject:
- memory disorders, etc ; acetylcholine; acetylcholinesterase; cells; hippocampus; memory; mice; neurons; peptides; synergism; testing; Show all 11 Subjects
- Abstract:
- ... This study aimed to explore the synergistic action of pentapeptides Gln-Met-Asp-Asp-Gln (QMDDQ) and Ala-Gly-Leu-Pro-Met (AGLPM) on memory improvement against scopolamine-induced impairment in mice compared to those of either peptide alone. In behavioral tests, the codelivery of QMDDQ and AGLPM was superior to the individual supplements of either peptide alone not only in enhancing the memory abili ...
- DOI:
- 10.1039/d0fo02570d
-
http://dx.doi.org/10.1039/d0fo02570d
- Author:
- Ferrell, Emily L.; Watford, Tanya S.; Braden, Abby
- Source:
- Appetite 2020 v.144 pp. 104450
- ISSN:
- 0195-6663
- Subject:
- memory disorders, etc ; anxiety; binging; cognition; college students; memory; regression analysis; risk factors; standard deviation; weight gain; Show all 10 Subjects
- Abstract:
- ... Emotional eating (EE), or eating in response to emotions, is related to depression, binge eating, and weight gain. Emotion regulation difficulties are a risk factor for EE. Working memory deficits may also be a risk factor for EE, as working memory is an important cognitive factor in emotion regulation. The current study is a secondary analysis that examined whether working memory moderated the re ...
- DOI:
- 10.1016/j.appet.2019.104450
-
https://dx.doi.org/10.1016/j.appet.2019.104450
- Author:
- Pang, Qianqian; Zhang, Weiyang; Li, Chenyang; Li, Haibo; Zhang, Yu; Li, Lin; Zang, Caixia; Yao, Xinsheng; Zhang, Dan; Yu, Yang
- Source:
- Food & function 2020 v.11 no.10 pp. 8825-8836
- ISSN:
- 2042-650X
- Subject:
- memory disorders, etc ; Gardenia; carotenoids; dementia; esters; fruits; hydrophilicity; learning; liquids; models; neuroprotective effect; oral administration; pharmacokinetics; saffron; spectroscopy; stigma; Show all 16 Subjects
- Abstract:
- ... Crocins, a series of hydrophilic carotenoids that are either mono- or di-glycosyl polyene esters of crocetin extracted from dried saffron stigma or fruits of gardenia, are attracting much attention due to their wide range of pharmacological effects. In our previous study, GJ-4, a mixture of crocin analogues, was obtained and derived from gardenia fruits. Mainly 18 crocin analogues were identified ...
- DOI:
- 10.1039/d0fo01678k
-
http://dx.doi.org/10.1039/d0fo01678k
- Author:
- Lyu, Yi; Ren, Xue‐Ke; Zhang, Hui‐Fang; Tian, Feng‐Jie; Mu, Jian‐Bing; Zheng, Jin‐Ping
- Source:
- Environmental toxicology 2020 v.35 no.9 pp. 961-970
- ISSN:
- 1520-4081
- Subject:
- memory disorders, etc ; ecotoxicology; glutamate receptors; hippocampus; inactivation; ion channels; males; memory; neurons; neurotoxicity; pollutants; protein phosphorylation; rats; signal transduction; Show all 14 Subjects
- Abstract:
- ... Benzo[a]pyrene (B[a]P) is recognized as a neurotoxic pollutant to mammals, which could impair learning and memory function. Although there is some evidence to suggest that N‐methyl‐d‐aspartate receptor (NMDAR), a glutamate receptor and ion channel protein in nerve cells, is involved into the B[a]P induced neurotoxicity, the exact molecular mechanisms remain to be elucidated, particularly the effec ...
- DOI:
- 10.1002/tox.22932
-
http://dx.doi.org/10.1002/tox.22932
- Author:
- Ruíz-Salinas, Ana Karen; Vázquez-Roque, Rubén A; Díaz, Alfonso; Pulido, Guadalupe; Treviño, Samuel; Floran, Benjamín; Flores, Gonzalo
- Source:
- The Journal of nutritional biochemistry 2020 v.83 pp. 108416
- ISSN:
- 0955-2863
- Subject:
- memory disorders, etc ; Lycium barbarum; antioxidants; caspase-3; hippocampus; memory; neurons; neuroplasticity; neuroprotective effect; prefrontal cortex; rats; therapeutics; Show all 12 Subjects
- Abstract:
- ... The main characteristic of brain aging is an exacerbated inflammatory and oxidative response that affects dendritic morphology and the function of the neurons of the prefrontal cortex (PFC) and the hippocampus. This consequently causes memory loss. Recently, the use of the Goji berry (Lycium barbarum) as an antioxidant extract has provided neuroprotection and neuroplasticity, however, its therapeu ...
- DOI:
- 10.1016/j.jnutbio.2020.108416
-
https://dx.doi.org/10.1016/j.jnutbio.2020.108416
- Author:
- Sirichoat, Apiwat; Suwannakot, Kornrawee; Chaisawang, Pornthip; Pannangrong, Wanassanun; Aranarochana, Anusara; Wigmore, Peter; Welbat, Jariya Umka
- Source:
- Life sciences 2020 v.248 pp. 117468
- ISSN:
- 0024-3205
- Subject:
- memory disorders, etc ; adults; animal models; cognitive disorders; fluorouracil; intravenous injection; males; melatonin; memory; neonates; neurogenesis; neurons; neuroprotective effect; patients; photoperiod; Show all 15 Subjects
- Abstract:
- ... Treatment with 5-fluorouracil (5-FU) can cause impairment to adult hippocampal neurogenesis, resulting in cognitive deficits. As melatonin has been shown to enhance memory and hippocampal neurogenesis in animal models, this research investigated the neuroprotective effects of melatonin against spatial memory and hippocampal neurogenesis impairment in 5-fluorouracil (5-FU)-treated rats.Four-Five we ...
- DOI:
- 10.1016/j.lfs.2020.117468
-
https://dx.doi.org/10.1016/j.lfs.2020.117468
- Author:
- Zhang, Zhongshan; Wang, Xiaomei; Pan, Yongliang; Wang, Guozhi; Mao, Genxiang
- Source:
- International journal of biological macromolecules 2020 v.146 pp. 725-729
- ISSN:
- 0141-8130
- Subject:
- memory disorders, etc ; Alzheimer disease; Pyropia; acetylcholine; acetylcholinesterase; amyloid; antioxidants; choline acetyltransferase; colorimetry; enzyme activity; memory; mice; neurotoxicity; peptides; polysaccharides; Show all 15 Subjects
- Abstract:
- ... An antioxidant polysaccharide, porphyran, from red algae Pyropia haitanensis, is introduced as a protective agent against neurotoxicity-induced amyloid β peptide (Aβ) of Alzheimer’s disease (AD) mice. Then the activity of acetylcholinesterase (AChE) and choline acetyltransferase (CHAT) in the cortical and hippocampal tissue were examined by colorimetric method. Results showed that porphyran signif ...
- DOI:
- 10.1016/j.ijbiomac.2019.09.243
-
https://dx.doi.org/10.1016/j.ijbiomac.2019.09.243
- Author:
- Li, Cai-Hong; Yang, Jun-Li
- Source:
- Food science and human wellness 2020 v.9 no.1 pp. 64-70
- ISSN:
- 2213-4530
- Subject:
- memory disorders, etc ; Alzheimer disease; Drosophila; Lycium; antioxidant activity; boiling; fruit extracts; genetically modified organisms; models; polysaccharides; China; Show all 11 Subjects
- Abstract:
- ... This study is to investigate the potential of wolfberry water extracts for the treatment of Alzheimer’s disease (AD) and the relationship between their anti-AD property and the geographic locations in China. Total extracts of all wolfberry samples showed the potent to decrease self-induced Aβ₁₋₄₂ aggregation and Cu²⁺-induced Aβ₁₋₄₂ aggregation and the antioxidant capacity as well as the bioactivit ...
- DOI:
- 10.1016/j.fshw.2019.12.007
-
http://dx.doi.org/10.1016/j.fshw.2019.12.007
- Author:
- Zhang, Changliang; Wang, Jing; Zhu, Jinling; Chen, Yabing; Han, Xiaodong
- Source:
- The Science of the total environment 2020 v.703 pp. 134702
- ISSN:
- 0048-9697
- Subject:
- memory disorders, etc ; apoptosis; blood-brain barrier; calcium; chronic exposure; enzymes; learning; mice; microcystin-LR; mitochondria; neurons; neurotoxicity; oxidative stress; phosphorylation; Show all 14 Subjects
- Abstract:
- ... Microcystin–leucine–arginine (MC-LR) can cross the blood–brain barrier (BBB) and demonstrate potent acute hippocampal neurotoxicity. Chronic exposure to MC-LR has been confirmed to cause learning and memory deficits in mice, but the potential molecular mechanism of MC-LR-caused neurotoxicity is still unclear. In this research, we observed that MC-LR induced oxidative stress, mitochondrial fission ...
- DOI:
- 10.1016/j.scitotenv.2019.134702
-
https://dx.doi.org/10.1016/j.scitotenv.2019.134702
- Author:
- Li, Xiaowei; Yang, Yu; Zhao, Hengzhi; Zhu, Tian; Yang, Zhihui; Xu, Haiyan; Fu, Yueqiang; Lin, Fan; Pan, Xiaoshu; Li, Long; Cui, Cheng; Hong, Min; Yang, Lu; Wang, Kevin K.; Tan, Weihong
- Source:
- Journal of the American Chemical Society 2020 v.142 no.8 pp. 3862-3872
- ISSN:
- 1520-5126
- Subject:
- memory disorders, etc ; blood plasma; blood-brain barrier; brain; brain damage; cognition; endothelial cells; oligonucleotides; phosphorylation; physiological transport; therapeutics; transferrin receptors; Show all 12 Subjects
- Abstract:
- ... The lack of blood–brain barrier (BBB) penetrating ability has hindered the delivery of many therapeutic agents for tauopathy treatment. In this study, we report the synthesis of a circular bifunctional aptamer to enhance the in vivo BBB penetration for better tauopathy therapy. The circular aptamer consists of one reported transferrin receptor (TfR) aptamer to facilitate TfR-aptamer recognition-in ...
- DOI:
- 10.1021/jacs.9b11490
-
http://dx.doi.org/10.1021/jacs.9b11490
- Author:
- Hsieh, Chung-Pin; Chen, Hao; Chan, Ming-Huan; Chen, Linyi; Chen, Hwei-Hsien
- Source:
- Toxicology 2020 v.446 pp. 152613
- ISSN:
- 0300-483X
- Subject:
- memory disorders, etc ; agonists; antagonists; binding sites; cognition; dose response; glycine (amino acid); males; memory; mice; monitoring; neuroplasticity; poisoning; protective effect; risk; synaptic transmission; toluene; Show all 17 Subjects
- Abstract:
- ... Toluene intoxication produces deleterious effects on cognitive function, which has been associated with the inhibition of N-methyl-d-aspartate receptor (NMDAR). The present study determined whether N,N-dimethylglycine (DMG), a nutrient supplement and a partial agonist for NMDAR glycine binding site, could counteract recognition memory deficits and hippocampal synaptic dysfunction after acute tolue ...
- DOI:
- 10.1016/j.tox.2020.152613
-
https://dx.doi.org/10.1016/j.tox.2020.152613
- Author:
- Sivasangari, Karunanithi; Rajan, Koilmani Emmanuvel
- Source:
- Antioxidants 2020 v.9 no.12
- ISSN:
- 2076-3921
- Subject:
- memory disorders, etc ; Bacopa monnieri; antioxidant activity; antioxidants; apoptosis; brain; cages; corticosterone; corticotropin; density; glucocorticoid receptors; memory; neurodevelopment; phosphorylation; pretreatment; progeny; protein kinases; rats; Show all 18 Subjects
- Abstract:
- ... Prenatal stress (PNS) influences offspring neurodevelopment, inducing anxiety-like behavior and memory deficits. We investigated whether pretreatment of Bacopa monnieri extract (CDRI-08/BME) ameliorates PNS-induced changes in signaling molecules, and changes in the behavior of Wistar rat offspring. Pregnant rats were randomly assigned into control (CON)/prenatal stress (PNS)/PNS and exposed to BME ...
- DOI:
- 10.3390/antiox9121229
-
http://dx.doi.org/10.3390/antiox9121229
- Author:
- Lee, Mei-Yi; Lin, Bih-Fen; Chan, Ming-Huan; Chen, Hwei-Hsien
- Source:
- Toxicology 2020 v.445 pp. 152602
- ISSN:
- 0300-483X
- Subject:
- memory disorders, etc ; adolescence; adolescents; adulthood; agonists; animal models; antagonism; antipsychotics; cognitive disorders; electrophysiology; haloperidol; head; hypersensitivity; males; mice; neurons; prefrontal cortex; receptors; social behavior; toluene; Show all 20 Subjects
- Abstract:
- ... Toluene has been characterized as a non-classical hallucinogen drug through activation of 5-HT₂A receptors and antagonism of NMDA receptors. It remains unclear whether psychotic symptoms after long-term and intense toluene exposure are associated with abnormalities in 5-HT₂A receptor function. The present study examined whether the responses to a hallucinogenic 5-HT₂A receptor agonist 2,5-dimethox ...
- DOI:
- 10.1016/j.tox.2020.152602
-
https://dx.doi.org/10.1016/j.tox.2020.152602
- Author:
- Ahmed, Ayaz; Zeng, Guirong; Azhar, Mudassar; Lin, Haiying; Zhang, Mijia; Wang, Fengzhong; Zhang, Hong; Jiang, Dejian; Yang, Sijin; Farooq, Ahsana Dar; Choudhary, Muhammad Iqbal; Liu, Xinmin; Wang, Qiong
- Source:
- Phytotherapy research 2020 v.34 no.12 pp. 3249-3261
- ISSN:
- 0951-418X
- Subject:
- memory disorders, etc ; Ophiopogon japonicus; Panax ginseng; Schisandra chinensis; Western blotting; blood glucose; brain; cognitive disorders; diabetes; histopathology; memory; phytotherapy; protein synthesis; proteins; rats; research; streptozotocin; testing; Show all 18 Subjects
- Abstract:
- ... Memory loss is a complication of diabetes which requires new approaches to its treatment. Shengmai San (SMS) is a famous traditional Chinese formula containing Panax ginseng, Ophiopogon japonicas, and Schisandra chinensis, whereas Radix puerariae has many reported pharmacological uses. In this study the combination, as Jiawei SMS (J‐SMS) was screened for its ability to reverse diabetes‐associated ...
- DOI:
- 10.1002/ptr.6773
-
http://dx.doi.org/10.1002/ptr.6773
- Author:
- Ma, Xinyi; Huang, Meng; Zheng, Mengna; Dai, Chengxiang; Song, Qingxiang; Zhang, Qian; Li, Qian; Gu, Xiao; Chen, Huan; Jiang, Gan; Yu, Ye; Liu, Xuesong; Li, Suke; Wang, Gang; Chen, Hongzhuan; Lu, Liangjing; Gao, Xiaoling
- Source:
- Journal of controlled release 2020 v.327 pp. 688-702
- ISSN:
- 0168-3659
- Subject:
- memory disorders, etc ; Alzheimer disease; brain; cognition; genes; intranasal administration; mesenchymal stromal cells; mice; neonates; neurogenesis; neuroglia; neurons; neuroprotective effect; pathogenesis; proteins; proteomics; sequence analysis; toxicity; transgenic animals; Show all 19 Subjects
- Abstract:
- ... Despite the various mechanisms that involved in the pathogenesis of Alzheimer's disease (AD), neuronal damage and synaptic dysfunction are the key events leading to cognition impairment. Therefore, neuroprotection and neurogenesis would provide essential alternatives to the rescue of AD cognitive function. Here we demonstrated that extracellular vesicles secreted from adipose-derived mesenchymal s ...
- DOI:
- 10.1016/j.jconrel.2020.09.019
-
https://dx.doi.org/10.1016/j.jconrel.2020.09.019
- Author:
- Zhou, Hai-rui; Wu, Jing-ru; Bei, Lei; Wang, Bai-xin; Xu, Hui; Wang, Jing-tao; Ma, Shu-xia
- Source:
- Food & function 2020 v.11 no.10 pp. 8978-8986
- ISSN:
- 2042-650X
- Subject:
- memory disorders, etc ; Abelmoschus manihot; antioxidant activity; antioxidant enzymes; brain; cognition; flowers; glutamate receptors; malondialdehyde; memory; mice; models; neuroprotective effect; oxidative stress; protein synthesis; sleep deprivation; tissues; tyrosine; Show all 18 Subjects
- Abstract:
- ... Previous researches have indicated that sleep plays a vital role in cognitive functions. Sleep deprivation (SD) causes learning and memory damage, which is associated with oxidative stress. This study was performed to investigate the neuroprotective effects of an extract of Abelmoschus manihot flower (EAM) against memory deficit induced by SD in mice. The SD model was evoked by multiple platform m ...
- DOI:
- 10.1039/d0fo02158j
-
http://dx.doi.org/10.1039/d0fo02158j
- Author:
- Wang, Hui; Meng, Guo-Liang; Zhang, Chun-Teng; Wang, Hao; Hu, Mei; Long, Yan; Hong, Hao; Tang, Su-Su
- Source:
- Journal of Asian natural products research 2020 v.22 no.9 pp. 864-878
- ISSN:
- 1477-2213
- Subject:
- memory disorders, etc ; Siraitia grosvenorii; Western blotting; frontal lobe; hippocampus; immunohistochemistry; ingredients; interleukin-1beta; interleukin-6; lipopolysaccharides; mice; oral administration; transcription factor NF-kappa B; tumor necrosis factor-alpha; Show all 14 Subjects
- Abstract:
- ... This study aimed to evaluate whether mogrol, a main bioactive ingredient of Siraitia grosvenorii, could attenuate LPS-induced memory impairment in mice. The behavioral tests and immunohistochemical analysis and Western blot were performed. The present results showed that oral administration of mogrol (20, 40, 80 mg/kg) significantly improved LPS-induced memory impairment in mice. The results also ...
- DOI:
- 10.1080/10286020.2019.1642878
-
http://dx.doi.org/10.1080/10286020.2019.1642878
- Author:
- Chen, Kai-Ge; Kang, Run-Run; Sun, Qian; Liu, Chang; Ma, Zhuo; Liu, Kuan; Deng, Yu; Liu, Wei; Xu, Bin
- Source:
- Toxicology 2020 v.442 pp. 152532
- ISSN:
- 0300-483X
- Subject:
- memory disorders, etc ; adolescence; adults; benzo(a)pyrene; biogenesis; children; embryogenesis; hippocampus; homeostasis; laboratory animals; memory; mitochondria; mitophagy; neurodevelopment; neurons; neurotoxicity; proteins; rats; resveratrol; signal transduction; Show all 20 Subjects
- Abstract:
- ... Exposure to benzo(a)pyrene (BaP) is associated with poor neurodevelopment in children and memory impairment in adults. Previous research has demonstrated that mitochondrial damage plays an important role in BaP-induced neurotoxicity. Of interest, increasing evidence has suggested that resveratrol (RSV) can alleviate nerve cell damage, however the exact mechanisms of biological activity in mitochon ...
- DOI:
- 10.1016/j.tox.2020.152532
-
https://dx.doi.org/10.1016/j.tox.2020.152532
- Author:
- Gugliandolo, Agnese; Chiricosta, Luigi; Boccardi, Virginia; Mecocci, Patrizia; Bramanti, Placido; Mazzon, Emanuela
- Source:
- Genes 2020 v.11 no.9
- ISSN:
- 2073-4425
- Subject:
- memory disorders, etc ; Alzheimer disease; amyloid; brain; cognition; computer simulation; gene expression regulation; genes; humans; messenger RNA; microRNA; neurodegenerative diseases; neurons; pathogenesis; patients; proteinases; translation (genetics); Show all 17 Subjects
- Abstract:
- ... MicroRNAs (miRNAs) are small RNAs involved in the post-transcriptional regulation of their target genes, causing a decrease in protein translation from the mRNA. Different miRNAs are found in the nervous system, where they are involved in its physiological functions, but altered miRNAs expression was also reported in neurodegenerative disorders, including Alzheimer’s disease (AD). AD is characteri ...
- DOI:
- 10.3390/genes11090983
-
http://dx.doi.org/10.3390/genes11090983