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1. Determination and evaluation of kinetic parameters of activated sludge biomass from a sludge reduction system treating real sewage by respirometry testing

Author:
Karlikanovaite-Balikci, Agne; Yagci, Nevin
Source:
Journal of environmental management 2019 v.240 pp. 303-310
ISSN:
0301-4797
Subject:
metabolism,   etc   ; activated sludge; biomass; models; sewage; viability;     Show all 6 Subjects
Abstract:
... Oxic-settling-anoxic (OSA) process is one of the promising variants that produces lower amounts of sludge and has been applied to aerobic and nutrient removal systems. The only consequence on this modification is that supplementary research is advisable to fully understand the mechanism, which eventually leads to the development of a more realistic model. This study evaluated the characteristics o ...
DOI:
10.1016/j.jenvman.2019.03.131

2. The role of 17βHSDs in breast tissue and breast cancers

Author:
McNamara, Keely May; Sasano, Hironobu
Source:
Molecular and cellular endocrinology 2019 v.489 pp. 32-44
ISSN:
0303-7207
Subject:
steroid metabolism,   etc   ; breast neoplasms; breasts; hydroxysteroid dehydrogenases;     Show all 4 Subjects
Abstract:
... The family of seventeen beta hydroxysteroid dehydrogenase enzymes has a long and diverse history in breast and breast cancer research. Given the known dependence of the breast on steroid signalling and intracrine steroid metabolism these enzymes are considered to be essential local fine tuners of overall steroid balance in the tissue. This review will cover the current state of knowledge regarding ...
DOI:
10.1016/j.mce.2018.10.019

3. The why and how of micro(nano)plastic research

Author:
Oliveira, M.; Almeida, M.
Source:
Trends in analytical chemistry 2019 v.114 pp. 196-201
ISSN:
0165-9936
Subject:
metabolism,   etc   ; energy; nanoplastics; neurotoxicity; pollution; risk;     Show all 6 Subjects
Abstract:
... The presence of small plastic particles in the environment, reported for the first time in the 1970's, has only recently been recognized as a global issue. Although environmental awareness continues to grow, so does its consumption and associated risks. The number of studies reporting the presence of microplastics, has grown exponentially as did the concern over plastic degradation into smaller pa ...
DOI:
10.1016/j.trac.2019.02.023

4. Dynamic Processing of Displacement Loops during Recombinational DNA Repair

Author:
Piazza, Aurèle; Shah, Shanaya Shital; Wright, William Douglass; Gore, Steven K.; Koszul, Romain; Heyer, Wolf-Dietrich
Source:
Molecular cell 2019 v.73 no.6 pp. 1255-1266.e4
ISSN:
1097-2765
Subject:
metabolism,   etc   ; DNA; DNA repair; adenosinetriphosphatase; homologous recombination;     Show all 5 Subjects
Abstract:
... Displacement loops (D-loops) are pivotal intermediates of homologous recombination (HR), a universal DNA double strand break (DSB) repair pathway. We developed a versatile assay for the physical detection of D-loops in vivo, which enabled studying the kinetics of their formation and defining the activities controlling their metabolism. Nascent D-loops are detected within 2 h of DSB formation and e ...
DOI:
10.1016/j.molcel.2019.01.005

5. Effects of MAO-A and CYP450 on primaquine metabolism in healthy volunteers

Author:
Ariffin, Norliza Mat; Islahudin, Farida; Kumolosasi, Endang; Makmor-Bakry, Mohd
Source:
Parasitology research 2019 v.118 no.3 pp. 1011-1018
ISSN:
0932-0113
Subject:
metabolism,   etc   ; Plasmodium vivax; drugs; genetics; malaria; parasites;     Show all 6 Subjects
Abstract:
... Eliminating the Plasmodium vivax malaria parasite infection remains challenging. One of the main problems is its capacity to form hypnozoites that potentially lead to recurrent infections. At present, primaquine is the only drug used for the management of hypnozoites. However, the effects of primaquine may differ from one individual to another. The aim of this work is to determine new measures to ...
DOI:
10.1007/s00436-019-06210-3

6. Insights into the spatial and temporal organisation of plant metabolism from network flux analysis

Author:
Moreira, Thiago Batista; Lima, Janderson Moraes; Coca, Guilherme Carvalho; Williams, Thomas Christopher Rhys
Source:
Theoretical and Experimental Plant Physiology 2019 v.31 no.1 pp. 215-226
ISSN:
2197-0025
Subject:
metabolism,   etc   ; isotope labeling; models; plant physiology; tissues;     Show all 5 Subjects
Abstract:
... The great complexity of plant metabolism, with multiple subcellular compartments, cell types, tissues and organs, greatly complicates its analysis. This problem is compounded by the extensive changes that occur in metabolism over time, both during day/night cycles and throughout the course of an entire life cycle. In this context in silico network flux analysis, including both isotope labelling an ...
DOI:
10.1007/s40626-018-0132-3

7. Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites

Author:
Luo, Jie; Jiang, Lu-Yi; Yang, Hongyuan; Song, Bao-Liang
Source:
Trends in biochemical sciences 2019 v.44 no.3 pp. 273-292
ISSN:
0968-0004
Subject:
metabolism,   etc   ; cholesterol; cytosol; hydrophobicity; organelles; proteins;     Show all 6 Subjects
Abstract:
... Cholesterol is dynamically transported among membrane-bound organelles primarily by nonvesicular mechanisms. Sterol transfer proteins (STPs) bind cholesterol in their hydrophobic pockets and facilitate its transfer across the aqueous cytosol. However, STPs alone may not account for the specific and efficient movement of cholesterol between intracellular membranes. Accumulating evidence has shown t ...
DOI:
10.1016/j.tibs.2018.10.001

8. Chromatin mobility upon DNA damage: state of the art and remaining questions

Author:
Zimmer, Christophe; Fabre, Emmanuelle
Source:
Current genetics 2019 v.65 no.1 pp. 1-9
ISSN:
0172-8083
Subject:
metabolism,   etc   ; DNA; DNA damage; chromatin; genome; yeasts;     Show all 6 Subjects
Abstract:
... Chromosome organization and chromatin mobility are central to DNA metabolism. In particular, it has been recently shown by several labs that double strand breaks (DSBs) in yeast induce a change in chromatin mobility at the site of the damage. Intriguingly, DSB also induces a global mobility of the genome, at others, potentially undamaged positions. How mobility is regulated and what are the functi ...
DOI:
10.1007/s00294-018-0852-6

9. Exploring the Diversity of Plant Metabolism

Author:
Fang, Chuanying; Fernie, Alisdair R.; Luo, Jie
Source:
Trends in plant science 2019 v.24 no.1 pp. 83-98
ISSN:
1360-1385
Subject:
metabolism,   etc   ; domestication; evolution; genetic variation; metabolites; phenotype;     Show all 6 Subjects
Abstract:
... Plants produce a huge array of metabolites, far more than those produced by most other organisms. Unraveling this diversity and its underlying genetic variation has attracted increasing research attention. Post-genomic profiling platforms have enabled the marriage and mining of the enormous amount of phenotypic and genetic diversity. We review here achievements to date and challenges remaining tha ...
DOI:
10.1016/j.tplants.2018.09.006

10. Harnessing Underground Metabolism for Pathway Development

Author:
Rosenberg, Jonathan; Commichau, Fabian M.
Source:
Trends in biotechnology 2019 v.37 no.1 pp. 29-37
ISSN:
0167-7799
Subject:
metabolism,   etc   ; biochemical pathways; genetically modified organisms; synthesis;     Show all 4 Subjects
Abstract:
... Fermentative production of valuable substances is an economically competitive and ecologically sustainable alternative to chemical synthesis, but it is often hampered by detrimental interactions between the heterologous pathway and the host metabolic network. These interactions are diverse and often not understood. However, the growing knowledge about convergently evolved pathways offers an expans ...
DOI:
10.1016/j.tibtech.2018.08.001

11. Inhibition and damage schemes within the synthesizing unit concept of dynamic energy budget theory

Author:
Muller, Erik B.; Klanjšček, Tin; Nisbet, Roger M.
Source:
Journal of sea research 2019 v.143 pp. 165-172
ISSN:
1385-1101
Subject:
metabolism,   etc   ; energy; enzyme kinetics; enzymes; social behavior;     Show all 5 Subjects
Abstract:
... Synthesizing Units (SU) concept plays an important role in organizing metabolism in Dynamic Energy Budget (DEB) theory. SUs are generalized units that bind and processes incoming streams of materials (substrates, generalized compounds, food, etc.) to yield one or more products. We use paradigms from enzyme kinetics to explore the impact of inhibitors and damaging agents on the dynamics of SUs requ ...
DOI:
10.1016/j.seares.2018.05.006

12. Natural product puerarin activates Akt and ameliorates glucose and lipid metabolism dysfunction in hepatic cells

Author:
Shen, Yunbing; Yang, Shengnan; Hu, Xueyan; Zhang, Man; Ma, Xiaoyao; Wang, Zhihua; Hou, Yuanyuan; Bai, Gang
Source:
Journal of functional foods 2019 v.55 pp. 296-304
ISSN:
1756-4646
Subject:
lipid metabolism; lipid metabolism disorders,   etc   ; dietary supplements; glucose; insulin; insulin resistance; lipids; phosphorylation; proteins;     Show all 9 Subjects
Abstract:
... Puerarin, one of the major isoflavonoid compounds isolated from Gegen, is widely used to treat glucose and lipid disorders. Identifying the mechanism of puerarin’s action against lipid and glucose metabolism dysfunction is very important for its application and development. Based on the structure of puerarin, different chemical probes were synthesized to capture and identify puerarin’s protein tar ...
DOI:
10.1016/j.jff.2019.02.035

13. Ambient fine particulate matter exposure induces cardiac functional injury and metabolite alterations in middle-aged female mice

Author:
Zhang, Yingying; Ji, Xiaotong; Ku, Tingting; Li, Ben; Li, Guangke; Sang, Nan
Source:
Environmental pollution 2019 v.248 pp. 121-132
ISSN:
0269-7491
Subject:
amino acid metabolism; carbohydrate metabolism; fatty acid metabolism,   etc   ; adults; cardiac output; cardiotoxicity; cardiovascular diseases; epidemiological studies; females; metabolic diseases; metabolites; mice; mitochondria; nicotinamide; particulates; ultrastructure;     Show all 16 Subjects
Abstract:
... Plenty of epidemiological studies have shown that exposure to ambient particulate matter (PM2.5) is linked to cardiovascular diseases (CVDs) in older even in middle-aged populations; however, experimental evidence through intuitive metabolic analysis to confirm the age susceptibility and explain the related molecular mechanism of PM2.5-induced cardiotoxicity is relatively rare. In the present stud ...
DOI:
10.1016/j.envpol.2019.01.080

14. Autotrophic nitrogen removal in combined nitritation and Anammox systems through intermittent aeration and possible microbial interactions by quorum sensing analysis

Author:
Sun, Yuepeng; Guan, Yuntao; Wang, Hongyang; Wu, Guangxue
Source:
Bioresource technology 2019 v.272 pp. 146-155
ISSN:
0960-8524
Subject:
amino acid metabolism; nitrogen metabolism; steroid metabolism,   etc   ; Chloroflexi; Proteobacteria; aeration; ammonium; anaerobic ammonium oxidation; biofilm; biosynthesis; fatty acids; glycosaminoglycans; heterotrophs; nitrites; nitrogen; quorum sensing;     Show all 16 Subjects
Abstract:
... Nitrogen removal and microbial interactions in two combined nitritation and Anammox systems with or without the addition of organics were examined. Two systems were successfully started up by adopting intermittent aeration. Organics addition deteriorated nitrogen removal, and total inorganic nitrogen and ammonium removal percentages decreased by 16.4% and 26.3%, respectively. Organics addition pro ...
DOI:
10.1016/j.biortech.2018.10.017

15. Rosennean Complexity and its relevance to ecology

Author:
Cárdenas, María Luz; Benomar, Saida; Cornish-Bowden, Athel
Source:
Ecological complexity 2018 v.35 pp. 13-24
ISSN:
1476-945X
Subject:
metabolism,   etc   ; catalysts; symbiosis; thermodynamics;     Show all 4 Subjects
Abstract:
... Complexity is not the same as complicatedness: a system is complicated if it has many components, but it is complex if it cannot be modelled as a machine and has emergent properties. The theoretical biologist Robert Rosen argued that living organisms are complex in this sense, and his (M, R) systems provide a description of a living organism in which the central point is that organisms are closed ...
DOI:
10.1016/j.ecocom.2017.04.005

16. Energetic Macroevolution of Vertebrates

Author:
Zotin, A. A.
Source:
Biology bulletin of the Russian Academy of Sciences 2018 v.45 no.4 pp. 299-309
ISSN:
1062-3590
Subject:
metabolism,   etc   ; heat; thermoregulation; vertebrates;     Show all 4 Subjects
Abstract:
... An analysis of our own data and published data on comparable standard metabolism in vertebrates has been carried out. It was shown that within each family and most of the orders this parameter varies insignificantly and the mean values for the comparable standard metabolism are grouped around certain values presumably corresponding to the stationary states to which organisms aspire in the course o ...
DOI:
10.1134/S1062359018040155

17. Correction to: Metabolism of L-arabinose in plants

Author:
Kotake, Toshihisa; Yamanashi, Yukiko; Imaizumi, Chiemi; Tsumuraya, Yoichi
Source:
Journal of plant research 2018 v.131 no.3 pp. 565
ISSN:
0918-9440
Subject:
metabolism,   etc   ; arabinose; Japan;     Show all 3 Subjects
Abstract:
... The article “Metabolism of L-arabinose in plants”, written by “Toshihisa Kotake, Yukiko Yamanashi, Chiemi Imaizumi, Yoichi Tsumuraya”, was originally published Online First without open access. After publication in volume129, issue 5, page 781–792 the Botanical Society of Japan decided to opt for Open Choice and to make the article an open access publication. ...
DOI:
10.1007/s10265-018-1012-2
PubMed:
29468321
PubMed Central:
PMC5916988

18. Plant genome-scale reconstruction: from single cell to multi-tissue modelling and omics analyses

Author:
Gomes de Oliveira Dal’Molin, Cristiana; Nielsen, Lars Keld
Source:
Current opinion in biotechnology 2018 v.49 pp. 42-48
ISSN:
0958-1669
Subject:
metabolism,   etc   ; models; tissues;     Show all 3 Subjects
Abstract:
... In this review, we present the latest developments in plant systems biology with particular emphasis on plant genome-scale reconstructions and multi-omics analyses. Understanding multicellular metabolism is far from trivial and ‘omics’ data are difficult to interpret in the absence of a systems framework. ‘Omics’ data appropriately integrated with genome-scale reconstructions and modelling facilit ...
DOI:
10.1016/j.copbio.2017.07.009

19. Artificial Biocatalytic Linear Cascades for Preparation of Organic Molecules

Author:
Schrittwieser, Joerg H.; Velikogne, Stefan; Hall, Mélanie; Kroutil, Wolfgang
Source:
Chemical reviews 2018 v.118 no.1 pp. 270-348
ISSN:
1520-6890
Subject:
metabolism,   etc   ; catalysts; enzymes; metabolites;     Show all 4 Subjects
Abstract:
... The review compiles artificial cascades involving enzymes with a focus on the last 10 years. A cascade is defined as the combination of at least two reaction steps in a single reaction vessel without isolation of the intermediates, whereby at least one step is catalyzed by an enzyme. Additionally, cascades performed in vivo and in vitro are discussed separately, whereby in vivo cascades are define ...
DOI:
10.1021/acs.chemrev.7b00033

20. Metabolic kinetic modeling provides insight into complex biological questions, but hurdles remain

Author:
Strutz, Jonathan; Martin, Jacob; Greene, Jennifer; Broadbelt, Linda; Tyo, Keith
Source:
Current opinion in biotechnology 2019 v.59 pp. 24-30
ISSN:
0958-1669
Subject:
metabolism,   etc   ; algorithms; catalytic activity; kinetics; metabolic engineering; models;     Show all 6 Subjects
Abstract:
... Metabolic models containing kinetic information can answer unique questions about cellular metabolism that are useful to metabolic engineering. Several kinetic modeling frameworks have recently been developed or improved. In addition, techniques for systematic identification of model structure, including regulatory interactions, have been reported. Each framework has advantages and limitations, wh ...
DOI:
10.1016/j.copbio.2019.02.005