U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Subject "metabolomics" Remove constraint Subject: "metabolomics"
Start Over

Search

13,002  Search Results

« Previous | 1 - 20 of 13,002 |
Number of results to display per page

Search Results

1. Synergy and sensitivity-balance in concatenating experiments in NO relaxation delay NMR (NORD)

Author:
István Timári; Tamás Milán Nagy; Katalin E. Kövér; Ole W. Sørensen
Source:
Chemical communications 2022 v.58 no.15 pp. 2516-2519
ISSN:
1364-548X
Subject:
metabolomics,   etc   ; experimental design; peptides;     Show all 3 Subjects
Abstract:
... The NMR experiment design strategy of NO Relaxation Delay (NORD), introduced mostly as an idealized theoretical approach, is extended and put to practical use by considering synergy and sensitivity-balance in concatenation of experiments. It is illustrated by a novel experiment, NORD {HMBC}–{HSQC}–{TOCSY}, where magnetization of non-¹³C attached protons effectively is channeled from the TOCSY spec ...
DOI:
10.1039/d1cc06663c

2. Microbial metabolomics: From novel technologies to diversified applications

Author:
Dongyang Ye; Xiaowei Li; Jianzhong Shen; Xi Xia
Source:
Trends in analytical chemistry 2022 v.148 pp. 116540
ISSN:
0165-9936
Subject:
metabolomics,   etc   ; analytical chemistry; secondary metabolites;     Show all 3 Subjects
Abstract:
... Microbial metabolomics focuses on the analysis of intracellular or extracellular primary metabolites, signaling molecules, hormones, and secondary metabolites, and it is an important field in systems biology. The progress in microbial metabolomics has been slow primarily due to the complexity and diversity of microbial metabolites, which are usually difficult to identify. However, with the rapid d ...
DOI:
10.1016/j.trac.2022.116540

3. Accelerating the development of biological nitrification inhibition as a viable nitrous oxide mitigation strategy in grazed livestock systems

Author:
Cecile A. M. de Klein; Saman Bowatte; Priscila L. Simon; Jacobo Arango; Laura M. Cardenas; David R. Chadwick; Jeroen Pijlman; Robert M. Rees; Karl G. Richards; Guntur V. Subbarao; David Whitehead
Source:
Biology and fertility of soils 2022 v.58 no.3 pp. 235-240
ISSN:
0178-2762
Subject:
metabolomics,   etc   ; livestock; nitrification; nitrous oxide; soil;     Show all 5 Subjects
Abstract:
... This position paper summarizes the current understanding of biological nitrification inhibition (BNI) to identify research needs for accelerating the development of BNI as a N₂O mitigation strategy for grazed livestock systems. We propose that the initial research focus should be on the systematic screening of agronomically desirable plants for their BNI potency and N₂O reduction potential. This r ...
DOI:
10.1007/s00374-022-01631-2

4. Biological machinery for polycyclic aromatic hydrocarbons degradation: A review

Author:
Arfin Imam; Sunil Kumar Suman; Pankaj K. Kanaujia; Anjan Ray
Source:
Bioresource technology 2022 v.343 pp. 126121
ISSN:
0960-8524
Subject:
metabolomics,   etc   ; bioremediation; biosurfactants; genes; technology; xenobiotics;     Show all 6 Subjects
Abstract:
... Polycyclic aromatic hydrocarbons (PAHs) are hazardous environmental pollutants with widespread and well-recognized health concerns. Amidst more than a hundred known PAHs, 16 are categorized as priority pollutants. Use of widely diverse biological machinery comprising bacteria, fungi, and algae harnessed from contaminated sites has emerged as an ecologically safe and sustainable approach for PAH de ...
DOI:
10.1016/j.biortech.2021.126121

5. Capturing the microbial volatilome: an oft overlooked 'ome'

Author:
Laura K. Meredith; Malak M. Tfaily
Source:
Trends in microbiology 2022 v.30 no.7 pp. 622-631
ISSN:
0966-842X
Subject:
metabolomics,   etc   ; metabolites; metabolome; volatile organic compounds;     Show all 4 Subjects
Abstract:
... Among the diverse metabolites produced by microbial communities, some are volatile. Volatile organic compounds (VOCs) are vigorously cycled by microbes as metabolic substrates and products and as signaling molecules. Yet, current microbial metabolomic studies predominantly focus on nonvolatile metabolites and overlook VOCs, which therefore represent a missing component of the metabolome. Advances ...
DOI:
10.1016/j.tim.2021.12.004

6. High-throughput plant phenotyping: a role for metabolomics?

Author:
Robert D. Hall; John C. D’Auria; Antonio C. Silva Ferreira; Yves Gibon; Dariusz Kruszka; Puneet Mishra; Rick van de Zedde
Source:
Trends in plant science 2022 v.27 no.6 pp. 549-563
ISSN:
1360-1385
Subject:
metabolomics,   etc   ; genotype-phenotype correlation; metabolites; phenotype;     Show all 4 Subjects
Abstract:
... High-throughput (HTP) plant phenotyping approaches are developing rapidly and are already helping to bridge the genotype–phenotype gap. However, technologies should be developed beyond current physico-spectral evaluations to extend our analytical capacities to the subcellular level. Metabolites define and determine many key physiological and agronomic features in plants and an ability to integrate ...
DOI:
10.1016/j.tplants.2022.02.001

7. IDSL.IPA Characterizes the Organic Chemical Space in Untargeted LC/HRMS Data Sets

Author:
Sadjad Fakouri Baygi; Yashwant Kumar; Dinesh Kumar Barupal
Source:
Journal of proteome research 2022 v.21 no.6 pp. 1485-1494
ISSN:
1535-3907
Subject:
metabolomics,   etc   ; chromatography; databases; exposome; proteome; research;     Show all 6 Subjects
Abstract:
... Generating comprehensive and high-fidelity metabolomics data matrices from LC/HRMS data remains to be extremely challenging for population-scale large studies (n > 200). Here, we present a new data processing pipeline, the Intrinsic Peak Analysis (IDSL.IPA) R package (https://ipa.idsl.me), to generate such data matrices specifically for organic compounds. The IDSL.IPA pipeline incorporates (1) ide ...
DOI:
10.1021/acs.jproteome.2c00120

8. Putting microbial interactions back into community contexts

Author:
Emily C Pierce; Rachel J Dutton
Source:
Current opinion in microbiology 2022 v.65 pp. 56-63
ISSN:
1369-5274
Subject:
metabolomics,   etc   ; biofilm; microbiology; microbiome; pH; toxicity;     Show all 6 Subjects
Abstract:
... Microbial interactions are key aspects of the biology of microbiomes. Recently, there has been a shift in the field towards studying interactions in more representative contexts, whether using multispecies model microbial communities or by looking at interactions in situ. Across diverse microbial systems, these studies have begun to identify common interaction mechanisms. These mechanisms include ...
DOI:
10.1016/j.mib.2021.10.008

9. A ‘shape-orientated’ algorithm employing an adapted Marr wavelet and shape matching index improves the performance of continuous wavelet transform for chromatographic peak detection and quantification

Author:
Caihong Bai; Suyun Xu; Jingyi Tang; Yuxi Zhang; Jiahui Yang; Kaifeng Hu
Source:
Journal of chromatography 2022 v.1673 pp. 463086
ISSN:
0021-9673
Subject:
metabolomics,   etc   ; algorithms; blood serum; humans; metabolites; wavelet;     Show all 6 Subjects
Abstract:
... A new ‘shape-orientated’ continuous wavelet transform (CWT)-based algorithm employing an adapted Marr wavelet (AMW) with a shape matching index (SMI), defined as peak height normalized wavelet coefficient (C′max/H) for feature filtering, was developed for chromatographic peak detection and quantification. Exploiting the chromatographic profile of a candidate peak, AMW-SMI algorithm emphasizes more ...
DOI:
10.1016/j.chroma.2022.463086

10. Advancement of omics techniques for chemical profile analysis and authentication of milk

Author:
Chenchen Qin; Lei Liu; Yu Wang; Tuo Leng; Mengting Zhu; Bei Gan; Jianhua Xie; Qiang Yu; Yi Chen
Source:
Trends in food science & technology 2022 pp. -
ISSN:
0924-2244
Subject:
metabolomics,   etc   ; animals; lipids; milk; milk composition; proteomics;     Show all 6 Subjects
Abstract:
... Milk is one of the most easily adulterated foods, and the fact that its milk composition is influenced by factors such as animal species and processing methods makes the identification of adulterated dairy products even more challenging. Therefore, there is a need for more accurate, faster and comprehensive techniques to address the problem of dairy product adulteration. As one of the rapidly deve ...
DOI:
10.1016/j.tifs.2022.06.001

11. Comparison of freshly squeezed, Non-thermally and thermally processed orange juice based on traditional quality characters, untargeted metabolomics, and volatile overview

Author:
Kewen Wang; Zhenzhen Xu
Source:
Food chemistry 2022 v.373 pp. 131430
ISSN:
0308-8146
Subject:
metabolomics,   etc   ; food chemistry; models; orange juice; pasteurization;     Show all 5 Subjects
Abstract:
... The NOVA food classification system, divides foods into four categories, namely unprocessed and minimally processed foods, processed culinary ingredients, processed foods, and ultra-processed foods. With the recently increasing pursuit of healthy diets, special attention to minimally processed foods has become crucial. According to NOVA, freshly squeezed, high pressure processing (HPP) and pasteur ...
DOI:
10.1016/j.foodchem.2021.131430

12. Understanding the fundamentals of microbial remediation with emphasize on metabolomics

Author:
Vaishnavi Jeevanandam; Jabez Osborne
Source:
Preparative biochemistry & biotechnology 2022 v.52 no.3 pp. 351-363
ISSN:
1532-2297
Subject:
metabolomics,   etc   ; biodegradation; bioremediation; biotechnology; genes; metabolites; xenobiotics;     Show all 7 Subjects
Abstract:
... The post-genomic tool metabolomics is a great advancement in science and technology which acquires novel strategies and pathways to analyze various biological compounds. Metabolomics aids in retrieving the qualitative and quantitative data from the various biological system. The current review is focused on the application of metabolomics in bioremediation and helps to focus on the xenobiotic comp ...
DOI:
10.1080/10826068.2021.1946694

13. A comprehensive strategy integrating metabolomics with multiple chemometric for discovery of function related active markers for assessment of foodstuffs: A case of hawthorn (Crataegus cuneata) fruits

Author:
Yan Cui; Kunze Du; Shixin Hou; Rui Yang; Lina Qi; Jin Li; Yanxu Chang
Source:
Food chemistry 2022 v.383 pp. 132464
ISSN:
0308-8146
Subject:
metabolomics,   etc   ; Crataegus; bioactive properties; chemometrics; food chemistry; fruits;     Show all 6 Subjects
Abstract:
... There is a growing demand for functional foodstuffs naturally rich in nutrients and bioactive compounds associated with putative health benefits. This study followed a strategy integrating metabolomic with chemometric to identify quality markers that can be used to distinguish function related bioactivity of fruits, using hawthorn (Crataegus cuneata) fruit as an example. The integrated strategy wa ...
DOI:
10.1016/j.foodchem.2022.132464

14. DEIMoS: An Open-Source Tool for Processing High-Dimensional Mass Spectrometry Data

Author:
Sean M. Colby; Christine H. Chang; Jessica L. Bade; Jamie R. Nunez; Madison R. Blumer; Daniel J. Orton; Kent J. Bloodsworth; Ernesto S. Nakayasu; Richard D. Smith; Yehia M. Ibrahim; Ryan S. Renslow; Thomas O. Metz
Source:
Analytical chemistry 2022 v.94 no.16 pp. 6130-6138
ISSN:
1520-6882
Subject:
metabolomics,   etc   ; algorithms; analytical chemistry; detection limit; instrumentation; isotopes;     Show all 6 Subjects
Abstract:
... We present DEIMoS: Data Extraction for Integrated Multidimensional Spectrometry, a Python application programming interface (API) and command-line tool for high-dimensional mass spectrometry data analysis workflows that offers ease of development and access to efficient algorithmic implementations. Functionality includes feature detection, feature alignment, collision cross section (CCS) calibrati ...
DOI:
10.1021/acs.analchem.1c05017

15. Micro- and nanoscale sensing of volatile organic compounds for early-stage cancer diagnosis

Author:
K.M. Mohibul Kabir; Merryn J. Baker; William A. Donald
Source:
Trends in analytical chemistry 2022 v.153 pp. 116655
ISSN:
0165-9936
Subject:
metabolomics,   etc   ; analytical chemistry; biomarkers; risk; volatile organic compounds;     Show all 5 Subjects
Abstract:
... A longstanding goal of oncology has been to accurately diagnose cancer at an early stage to improve clinical outcomes. Ideally, such testing would be inexpensive, non-invasive, involve minimal risk, and be scalable to large populations. Volatile biomarkers for early detection can be sampled readily from breath and bodily fluids non-invasively. Herein, the major advances in metabolomics for early-s ...
DOI:
10.1016/j.trac.2022.116655

16. Molecular insights into plant–microbe interactions for sustainable remediation of contaminated environment

Author:
Niraj R. Rane; Savita Tapase; Aakansha Kanojia; Anuprita Watharkar; El-Sayed Salama; Min Jang; Krishna Kumar Yadav; Mohammed A. Amin; Marina M.S. Cabral-Pinto; Jyoti P. Jadhav; Byong-Hun Jeon
Source:
Bioresource technology 2022 v.344 pp. 126246
ISSN:
0960-8524
Subject:
metabolomics,   etc   ; endophytes; industrialization; phytoremediation; proteomics; rhizosphere; technology; transcriptomics;     Show all 8 Subjects
Abstract:
... The widespread distribution of organic and inorganic pollutants in water resources have increased due to rapid industrialization. Rhizospheric zone-associated bacteria along with endophytic bacteria show a significant role in remediation of various pollutants. Metaomics technologies are gaining an advantage over traditional methods because of their capability to obtain detailed information on excl ...
DOI:
10.1016/j.biortech.2021.126246

17. Synthesis of Non-natural Aza-Iridoids via Ynamides and Molecular Networking-Based Tracing of Their In Planta Bioconversion

Author:
Baptiste Moegle; Maxime Hourtoule; Clément Gommenginger; Asmaa Belabbes; Claire Villette; David Elser; Emmanuel Gaquerel; Nicolas Navrot; Laurence Miesch
Source:
Journal of organic chemistry 2022 v.87 no.11 pp. 7229-7238
ISSN:
1520-6904
Subject:
metabolomics,   etc   ; Scrophularia; biotransformation; mass spectrometry; organic chemistry; secoiridoids;     Show all 6 Subjects
Abstract:
... A synthesis of new-to-nature aza-iridoids via ynamides is presented. ZrCl₄ proved to be the best acid to perform this transformation. Various ynamides were accommodated, and seco-iridoids could be obtained as well. Aza-iridoids were infiltrated into leaves of Scrophularia Nodosa, an iridoid-producing plant species. High-resolution mass spectrometry coupled to computational metabolomic approaches w ...
DOI:
10.1021/acs.joc.2c00445

18. Capturing the third dimension in drug discovery: Spatially-resolved tools for interrogation of complex 3D cell models

Author:
Daniel Simão; Catarina M. Gomes; Paula M. Alves; Catarina Brito
Source:
Biotechnology advances 2022 v.55 pp. 107883
ISSN:
0734-9750
Subject:
metabolomics,   etc   ; biotechnology; drugs; human development; proteomics; spatial data; transcriptomics;     Show all 7 Subjects
Abstract:
... Advanced three-dimensional (3D) cell models have proven to be capable of depicting architectural and microenvironmental features of several tissues. By providing data of higher physiological and pathophysiological relevance, 3D cell models have been contributing to a better understanding of human development, pathology onset and progression mechanisms, as well as for 3D cell-based assays for drug ...
DOI:
10.1016/j.biotechadv.2021.107883

19. Current state and future perspectives of supercritical fluid chromatography

Author:
Le Si-Hung; Takeshi Bamba
Source:
Trends in analytical chemistry 2022 v.149 pp. 116550
ISSN:
0165-9936
Subject:
metabolomics,   etc   ; analytical chemistry; food science; metabolites; supercritical fluid chromatography;     Show all 5 Subjects
Abstract:
... For quite of time, supercritical fluid chromatography (SFC) is expected to make a big revolution in separation technologies. The technique is well known for developing fast and ultrafast high efficiency separation, improving the analytical method greenness. The evolution of SFC technologies (i.e., instrumentations, stationary phases) have shifted dramatically trends in SFC application from the chi ...
DOI:
10.1016/j.trac.2022.116550

20. Impact of different cooking methods on the chemical profile of high-oleic acid peanut seeds

Author:
Yuan Xiao; Hao Liu; Puxuan Du; Xuanqiang Liang; Haifen Li; Qing Lu; Shaoxiong Li; Haiyan Liu; Yanbin Hong; Rajeev K. Varshney; Xiaoping Chen
Source:
Food chemistry 2022 v.379 pp. 131970
ISSN:
0308-8146
Subject:
metabolomics,   etc   ; food chemistry; human health; metabolites; oleic acid; peanuts;     Show all 6 Subjects
Abstract:
... High oleic acid (OA) peanut seeds (PS) can be beneficial for human health. However, chemical variations in high-OA PS after domestic cooking are not fully understood. In order to investigate the impact of different cooking methods on the chemical profile of high-OA PS, widely established metabolomics approach was employed to identify the relative contents of PS metabolites. Herein, 630 metabolites ...
DOI:
10.1016/j.foodchem.2021.131970