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You searched for: Subject "microbial genetics" Remove constraint Subject: "microbial genetics"
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1. Fungal cell death: The beginning of the end

Author:
Adriana M. Rico-Ramírez; A. Pedro Gonçalves; N. Louise Glass
Source:
Fungal genetics and biology 2022 v.159 pp. 103671
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Animalia; cell death; cell fusion; death; fungi; lifestyle; meiotic drive;     Show all 8 Subjects
Abstract:
... Death is an important part of an organism’s existence and also marks the end of life. On a cellular level, death involves the execution of complex processes, which can be classified into different types depending on their characteristics. Despite their “simple” lifestyle, fungi carry out highly specialized and sophisticated mechanisms to regulate the way their cells die, and the pathways underlyin ...
DOI:
10.1016/j.fgb.2022.103671

2. Candida albicans MTLa2 regulates the mating response through both the a-factor and α-factor sensing pathways

Author:
Chao Li; Li Tao; Zhangyue Guan; Tianren Hu; Sijia Wang; Weihong Liang; Fei Zhao; Guanghua Huang
Source:
Fungal genetics and biology 2022 v.159 pp. 103664
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Candida albicans; diploidy; fungi; heterozygosity; homozygosity; loci; pathogens; phenotype; sexual reproduction; transcription (genetics);     Show all 11 Subjects
Abstract:
... The diploid fungal pathogen Candida albicans has three configurations at the mating type locus (MTL): heterozygous (a/α) and homozygous (a/a or α/α). C. albicans MTL locus encodes four transcriptional regulators (MTLa1, a2, α1, and α2). The conserved a1/α2 heterodimer controls not only mating competency but also white-opaque heritable phenotypic switching. However, the regulatory roles of MTLa2 an ...
DOI:
10.1016/j.fgb.2022.103664

3. Visualising long distance sugar transport in fungi using infrared fluorescence scanning imaging

Author:
Robert-Jan Bleichrodt; Han A.B. Wösten
Source:
Fungal genetics and biology 2022 v.161 pp. 103699
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Agaricus bisporus; Schizophyllum commune; deoxyglucose; fluorescence; hyphae; microscopy; mycelium; nutrient availability; nutrient transport; radiolabeling; saprotrophs;     Show all 12 Subjects
Abstract:
... Mycelia of saprotrophic basidiomycetes can cover large areas in nature that are typified by their heterogeneous nutrient availability. This heterogeneity is overcome by long distance transport of nutrients within the hyphal network to sites where they are needed. It is therefore key to be able to study nutrient transport and its underlying mechanisms. An IRDye-conjugate was used for the first time ...
DOI:
10.1016/j.fgb.2022.103699

4. Extracellular targeting of Neurospora crassa cell wall and secreted glycoproteins by DFG-5

Author:
Pavan K. Patel; Sook Keng Tung; Sara Porfirio; Roberto Sonon; Parastoo Azadi; Stephen J. Free
Source:
Fungal genetics and biology 2022 v.160 pp. 103686
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Neurospora crassa; active sites; biogenesis; cell walls; enzyme activity; fungi; galactomannans; glycoproteins; site-directed mutagenesis; transferases;     Show all 11 Subjects
Abstract:
... The formation of a cell wall is vital for the survival and growth of a fungal cell. Fungi express members of the GH76 family of α-1,6-mannanases which play an important role in cell wall biogenesis. In this report we characterize the Neurospora crassa DFG-5 α-1,6-mannanase and demonstrate that it binds to the α-1,6-mannose backbone of an N-linked galactomannan found on cell wall glycoproteins. We ...
DOI:
10.1016/j.fgb.2022.103686

5. BcHnm1, a predicted choline transporter, modulates conidial germination and virulence in Botrytis cinerea

Author:
Gulab Chand Arya; Dhruv Aditya Srivastava; Ekaterina Manasherova; Dov B. Prusky; Yigal Elad; Omer Frenkel; Arye Harel
Source:
Fungal genetics and biology 2022 v.158 pp. 103653
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Botrytis cinerea; choline; conidia; genomics; germ tube; germination; green beans; imports; mutants; plant pathogenic fungi; tomatoes; virulence;     Show all 13 Subjects
Abstract:
... Previous network-based comparative genomic analysis between major lifestyles of fungal plant pathogens highlighted that HNM1, a predicted choline transporter, is part of the necrotroph core-genome's functions. In this work we have generated and characterized deletion mutants and developed complemented strains for the HNM1 homolog (Bchnm1) in the necrotrophic model fungal plant pathogen Botrytis ci ...
DOI:
10.1016/j.fgb.2021.103653

6. Role of the anillin-like protein in growth of Cryptococcus neoformans at human host temperature

Author:
Congyue A. Peng; Sophie Altamirano; Namrata Paladugu; Logan P. Crowe; Inas F. Aboobakar; Srikripa Chandrasekaran; Lukasz Kozubowski
Source:
Fungal genetics and biology 2022 v.160 pp. 103697
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Cryptococcus neoformans; Galleria mellonella; Saccharomyces cerevisiae; cytokinesis; fluconazole; genetically modified organisms; humans; meningitis; neck; temperature; virulence; yeasts;     Show all 13 Subjects
Abstract:
... Cryptococcus neoformans, a basidiomycete yeast, causes lethal meningitis in immunocompromised individuals. The ability of C. neoformans to proliferate at 37°C is essential for virulence. We identified anillin-like protein, CnBud4, as essential for proliferation of C. neoformans at 37°C and for virulence in a heterologous host Galleria mellonella at 25°C. C. neoformans cells lacking CnBud4 were inv ...
DOI:
10.1016/j.fgb.2022.103697

7. The Zymoseptoria tritici white collar-1 gene, ZtWco-1, is required for development and virulence on wheat

Author:
Anna M.M Tiley; Colleen Lawless; Paola Pilo; Sujit J. Karki; Jijun Lu; Zhuowei Long; Hesham Gibriel; Andy M. Bailey; Angela Feechan
Source:
Fungal genetics and biology 2022 v.161 pp. 103715
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Mycosphaerella graminicola; Neurospora crassa; blue light; circadian clocks; fungi; genes; hyphae; melanization; pathogens; photoreceptors; virulence; wheat; Europe;     Show all 14 Subjects
Abstract:
... The fungus Zymoseptoria tritici causes Septoria Tritici Blotch (STB), which is one of the most devastating diseases of wheat in Europe. There are currently no fully durable methods of control against Z. tritici, so novel strategies are urgently required. One of the ways in which fungi are able to respond to their surrounding environment is through the use of photoreceptor proteins which detect lig ...
DOI:
10.1016/j.fgb.2022.103715

8. A gene cluster with positive and negative elements controls bistability and hysteresis of the crippled versus normal growth in the fungus Podospora anserina

Author:
Tinh-Suong Nguyen; Valérie Gautier; Laetitia Chan Ho Tong; Philippe Silar
Source:
Fungal genetics and biology 2022 v.161 pp. 103711
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Podospora anserina; fungi; gene deletion; genetic background; hysteresis; introgression; loci; mitogen-activated protein kinase; multigene family; sequence analysis;     Show all 11 Subjects
Abstract:
... The Crippled Growth (CG) cell degeneration of the model ascomycete Podospora anserina (strain S) is controlled by a prion-like element and has been linked to the self-activation of the PaMpk1 MAP kinase cascade. Here, we report on the identification of the “86–11” locus containing twelve genes, ten of which are involved either in setting up the self-activation loop of CG or in inhibiting this loop ...
DOI:
10.1016/j.fgb.2022.103711

9. Intra-hemocoel injection of pseurotin A from Metarhizium anisopliae, induces dose-dependent reversible paralysis in the Greater Wax Moth (Galleria mellonella)

Author:
Nicolau Sbaraini; Chin-Soon Phan; Eden Silva e Souza; Ana Paula A. Perin; Hamideh Rezaee; Felipe Geremia; Matheus da Silva Camargo; Euzébio Guimarães Barbosa; Augusto Schrank; Yit-Heng Chooi; Charley Christian Staats
Source:
Fungal genetics and biology 2022 v.159 pp. 103675
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Galleria mellonella; Metarhizium anisopliae; biosynthesis; chitin synthase; conidia; culture media; dose response; hemocoel; immunoglobulin E; mortality; paralysis; secondary metabolites;     Show all 13 Subjects
Abstract:
... Species from the Metarhizium genus are the causal agents of the green muscardine disease of insects. These fungi have been successfully employed for the biological control of pests over decades. Besides the biocontrol applications, recent efforts for genome sequencing of species in this genus have revealed a great diversity of biosynthetic gene clusters potentially associated with secondary metabo ...
DOI:
10.1016/j.fgb.2022.103675

10. An Indian lineage of Histoplasma with strong signatures of differentiation and selection

Author:
Gaston I. Jofre; Ashutosh Singh; Heidi Mavengere; Gandhi Sundar; Emmanuel D'Agostino; Anuradha Chowdhary; Daniel R. Matute
Source:
Fungal genetics and biology 2022 v.158 pp. 103654
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Histoplasma; cryptic species; fungi; genetic variation; histoplasmosis; humans; natural selection; phylogeny; population genetics; respiratory tract diseases; virulence; virulent strains; India;     Show all 14 Subjects
Abstract:
... Histoplasma, a genus of dimorphic fungi, is the etiological agent of histoplasmosis, a pulmonary disease widespread across the globe. Whole genome sequencing has revealed that the genus harbors a previously unrecognized diversity of cryptic species. To date, studies have focused on Histoplasma isolates collected in the Americas with little knowledge of the genomic variation from other localities. ...
DOI:
10.1016/j.fgb.2021.103654

11. Austropuccinia psidii uses tetrapolar mating and produces meiotic spores in older infections on Eucalyptus grandis

Author:
Jessica A. Ferrarezi; Alistair R. McTaggart; Peri A. Tobias; Carolina A.A. Hayashibara; Rebecca M. Degnan; Louise S. Shuey; Livia M. Franceschini; Mariana S. Lopes; Maria C. Quecine
Source:
Fungal genetics and biology 2022 v.160 pp. 103692
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Eucalyptus grandis; Myrtus communis; Puccinia; Sphaerophragmium; Syzygium jambos; biosecurity; genomics; haplotypes; host range; loci; meiosis; mitosis; pheromones; sexual reproduction; teliospores;     Show all 16 Subjects
Abstract:
... Austropuccinia psidii is the causal agent of myrtle rust, a fungal disease that infects over 480 species in the Myrtaceae. A. psidii is a biotrophic pathogen that reproduces sexually and asexually. Sexual reproduction has been previously shown on Syzygium jambos and little is known about its reproductive biology on other hosts or whether populations that were formerly structured by host range can ...
DOI:
10.1016/j.fgb.2022.103692

12. Function of the phosphatidylinositol synthase Pis1 in maintenance of endoplasmic reticulum function and pathogenicity in Candida albicans

Author:
Yingzheng Liu; Congcong Ma; Xiaolong Mao; Qiang Zhao; Dixiong Yu; Li Yang; Mingchun Li
Source:
Fungal genetics and biology 2022 v.160 pp. 103674
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Candida albicans; cell walls; death; endoplasmic reticulum; fungi; genes; humans; hydrolases; metabolism; mice; mutants; secretion; stress response; virulence; virulent strains;     Show all 16 Subjects
Abstract:
... Candida albicans is a common conditional pathogenic fungus in the human body, and its infections have received widespread attention in recent years. Phosphatidylinositol and its derivatives have significant regulatory effects on many physiological processes, such as cell metabolism and growth. In this study, we identified and studied the function of the phosphatidylinositol synthase Pis1 in Candid ...
DOI:
10.1016/j.fgb.2022.103674

13. Candida glabrata Hst1-Rfm1-Sum1 complex evolved to control virulence-related genes

Author:
Norma Vázquez-Franco; Guadalupe Gutiérrez-Escobedo; Alejandro Juárez-Reyes; Emmanuel Orta-Zavalza; Irene Castaño; Alejandro De Las Peñas
Source:
Fungal genetics and biology 2022 v.159 pp. 103656
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; ABC transporters; Candida glabrata; DNA; Saccharomycetaceae; adhesins; biofilm; epithelium; fluconazole; fungi; histone deacetylase; humans; neutrophils; oxidative stress; pathogens; phylogeny; virulence; xenobiotics;     Show all 18 Subjects
Abstract:
... C. glabrata is an opportunistic fungal pathogen and the second most common cause of opportunistic fungal infections in humans, that has evolved virulence factors to become a successful pathogen: strong resistance to oxidative stress, capable to adhere and form biofilms in human epithelial cells as well as to abiotic surfaces and high resistance to xenobiotics. Hst1 (a NAD⁺-dependent histone deacet ...
DOI:
10.1016/j.fgb.2021.103656

14. Microbial Genetics: Stress Management

Author:
Shankar Iyer; Sonia Muliyil
Source:
Trends in microbiology 2021 v.29 no.1 pp. 1-3
ISSN:
0966-842X
Subject:
microbial genetics,   etc   ; humans; stress management;     Show all 3 Subjects
Abstract:
... Microbes constitute the very core of our existence. Long believed to be a nuisance and proponents of various diseases, latest research point toward their functions in processes that can prove beneficial for human survival and afford long-term protection from disease. The wide range of functions exhibited by a host of microbes implies diversity and heterogeneity at the level of the molecular machin ...
DOI:
10.1016/j.tim.2020.10.015

15. Genomic regions associated with virulence in Setosphaeria turcica identified by linkage mapping in a biparental population

Author:
Pummi Singh; Shun-Yuan Huang; Alvaro G. Hernandez; Pragya Adhikari; Tiffany M. Jamann; Santiago X. Mideros
Source:
Fungal genetics and biology 2022 v.159 pp. 103655
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Setosphaeria turcica; ascospores; chromosome mapping; conidiation; corn; fungi; genome; genomics; genotyping; greenhouses; host specificity; hyphae; leaf blight; loci; pathogens; phenotype; saprotrophs; virulence;     Show all 19 Subjects
Abstract:
... Northern corn leaf blight (NCLB) and sorghum leaf blight (SLB) are significant diseases of maize and sorghum, respectively, caused by the filamentous fungus Setosphaeria turcica. Strains of S. turcica are typically host-specific and infect either maize or sorghum. Host specificity in this pathogen is attributed to a single locus for maize and a second distinct locus for sorghum. To identify the ge ...
DOI:
10.1016/j.fgb.2021.103655

16. Two typical acyl-CoA-binding proteins (ACBPs) are required for the asexual development and virulence of Phytophthora sojae

Author:
Yong Pei; Jierui Si; Natasha Navet; Peiyun Ji; Xiong Zhang; Huijun Qiao; Ruofei Xu; Ying Zhai; Jianqiang Miao; Brett M. Tyler; Daolong Dou
Source:
Fungal genetics and biology 2022 v.161 pp. 103695
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; CRISPR-Cas systems; Phytophthora sojae; acyl coenzyme A; eukaryotic cells; germination; lipid metabolism; lipids; pathogens; phenotype; soybeans; sporangia; vegetative growth; virulence; zoospores;     Show all 15 Subjects
Abstract:
... Being found in all eukaryotes investigated, acyl-CoA-binding proteins (ACBPs) participate in lipid metabolism via specifically binding acyl-CoA esters with high affinity. The structures and functions of ACBP family proteins have been extensively described in yeasts, fungi, plants and mammals, but not oomycetes. In the present study, seven ACBP genes named PsACBP1-7 were identified from the genome ...
DOI:
10.1016/j.fgb.2022.103695
CHORUS:
10.1016/j.fgb.2022.103695

17. Functional roles of all five putative hydrophobin genes in growth, development, and secondary metabolism in Fusarium graminearum

Author:
Yoo-Kyoung Shin; Da-Woon Kim; Sang-Won Lee; Mi-Jeong Lee; Seul Gi Baek; Theresa Lee; Sung-Hwan Yun
Source:
Fungal genetics and biology 2022 v.160 pp. 103683
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Fusarium graminearum; Fusarium head blight; conidia; conidiation; cysteine; fungi; gene deletion; gene expression; hydrophobins; hyphae; metabolism; pathogenicity; perithecia; phenotype; rice; sequence analysis; trichothecenes;     Show all 18 Subjects
Abstract:
... Fusarium graminearum is the causal agent of Fusarium head blight in cereal crops. As in other filamentous ascomycetes, F. graminearum contains genes encoding putative hydrophobins, which are small secreted amphiphilic proteins with eight conserved cysteine residues. Here, we investigated the roles of all five hydrophobin genes (designated FgHyd1, FgHyd2, FgHyd3, FgHyd4, and FgHyd5) in various myco ...
DOI:
10.1016/j.fgb.2022.103683

18. WITHDRAWN: Fatty acid dioxygenase-cytochrome P450 fusion enzymes of the top 10 fungal pathogens in molecular plant pathology and human-pathogenic fungi

Author:
Ernst H. Oliw
Source:
Fungal genetics and biology 2021 pp. 103603
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; fatty acids; plant pathology;     Show all 3 Subjects
Abstract:
... This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal ...
DOI:
10.1016/j.fgb.2021.103603

19. Acetolactate synthases regulatory subunit and catalytic subunit genes VdILVs are involved in BCAA biosynthesis, microscletotial and conidial formation and virulence in Verticillium dahliae

Author:
ShengNan Shao; Biao Li; Qi Sun; PeiRu Guo; YeJuan Du; JiaFeng Huang
Source:
Fungal genetics and biology 2022 v.159 pp. 103667
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Verticillium dahliae; Verticillium wilt; acetolactate synthase; auxotrophs; biosynthesis; conidia; cotton; fungal growth; fungi; gene targeting; isoleucine; leucine; morphogenesis; phenotype; protein subunits; regulator genes; tribenuron; valine; virulence;     Show all 20 Subjects
Abstract:
... Acetolactate synthase (AHAS) catalyses the first common step in the biosynthesis pathways of three branched-chain amino acids (BCAAs) of valine, isoleucine and leucine. Here, we characterized one regulatory subunit (VdILV6) and three catalytic subunits (VdILV2A, VdILV2B and VdILV2C) of AHAS from the important cotton Verticillium wilt fungus Verticillium dahliae. Phenotypic analysis showed that VdI ...
DOI:
10.1016/j.fgb.2022.103667

20. The spindle pole-body localization of activated cytoplasmic dynein is cell cycle-dependent in Aspergillus nidulans

Author:
Baronger Dowell Bieger; Aysha H. Osmani; Xin Xiang; Martin J. Egan
Source:
Fungal genetics and biology 2021 v.148 pp. 103519
ISSN:
1087-1845
Subject:
microbial genetics,   etc   ; Aspergillus nidulans; dynein ATPase; interphase; microtubules;     Show all 5 Subjects
Abstract:
... Cytoplasmic dynein is a minus end-directed microtubule motor that can be activated by cargo adapters. In Aspergillus nidulans, overexpression of ΔC-HookA, the early endosomal adapter HookA missing its cargo-binding site, causes activated dynein to accumulate at septa and spindle pole bodies (SPBs) where the microtubule-organizing centers are located. Intriguingly, only some interphase nuclei show ...
DOI:
10.1016/j.fgb.2021.103519