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microbialgenetics, etc ; Animalia; cell death; cell fusion; death; fungi; lifestyle; meiotic drive; Show all 8 Subjects
Abstract:
... Death is an important part of an organism’s existence and also marks the end of life. On a cellular level, death involves the execution of complex processes, which can be classified into different types depending on their characteristics. Despite their “simple” lifestyle, fungi carry out highly specialized and sophisticated mechanisms to regulate the way their cells die, and the pathways underlyin ...
microbialgenetics, etc ; Candida albicans; diploidy; fungi; heterozygosity; homozygosity; loci; pathogens; phenotype; sexual reproduction; transcription (genetics); Show all 11 Subjects
Abstract:
... The diploid fungal pathogen Candida albicans has three configurations at the mating type locus (MTL): heterozygous (a/α) and homozygous (a/a or α/α). C. albicans MTL locus encodes four transcriptional regulators (MTLa1, a2, α1, and α2). The conserved a1/α2 heterodimer controls not only mating competency but also white-opaque heritable phenotypic switching. However, the regulatory roles of MTLa2 an ...
... Mycelia of saprotrophic basidiomycetes can cover large areas in nature that are typified by their heterogeneous nutrient availability. This heterogeneity is overcome by long distance transport of nutrients within the hyphal network to sites where they are needed. It is therefore key to be able to study nutrient transport and its underlying mechanisms. An IRDye-conjugate was used for the first time ...
microbialgenetics, etc ; Neurospora crassa; active sites; biogenesis; cell walls; enzyme activity; fungi; galactomannans; glycoproteins; site-directed mutagenesis; transferases; Show all 11 Subjects
Abstract:
... The formation of a cell wall is vital for the survival and growth of a fungal cell. Fungi express members of the GH76 family of α-1,6-mannanases which play an important role in cell wall biogenesis. In this report we characterize the Neurospora crassa DFG-5 α-1,6-mannanase and demonstrate that it binds to the α-1,6-mannose backbone of an N-linked galactomannan found on cell wall glycoproteins. We ...
microbialgenetics, etc ; Botrytis cinerea; choline; conidia; genomics; germ tube; germination; green beans; imports; mutants; plant pathogenic fungi; tomatoes; virulence; Show all 13 Subjects
Abstract:
... Previous network-based comparative genomic analysis between major lifestyles of fungal plant pathogens highlighted that HNM1, a predicted choline transporter, is part of the necrotroph core-genome's functions. In this work we have generated and characterized deletion mutants and developed complemented strains for the HNM1 homolog (Bchnm1) in the necrotrophic model fungal plant pathogen Botrytis ci ...
... Cryptococcus neoformans, a basidiomycete yeast, causes lethal meningitis in immunocompromised individuals. The ability of C. neoformans to proliferate at 37°C is essential for virulence. We identified anillin-like protein, CnBud4, as essential for proliferation of C. neoformans at 37°C and for virulence in a heterologous host Galleria mellonella at 25°C. C. neoformans cells lacking CnBud4 were inv ...
microbialgenetics, etc ; Mycosphaerella graminicola; Neurospora crassa; blue light; circadian clocks; fungi; genes; hyphae; melanization; pathogens; photoreceptors; virulence; wheat; Europe; Show all 14 Subjects
Abstract:
... The fungus Zymoseptoria tritici causes Septoria Tritici Blotch (STB), which is one of the most devastating diseases of wheat in Europe. There are currently no fully durable methods of control against Z. tritici, so novel strategies are urgently required. One of the ways in which fungi are able to respond to their surrounding environment is through the use of photoreceptor proteins which detect lig ...
microbialgenetics, etc ; Podospora anserina; fungi; gene deletion; genetic background; hysteresis; introgression; loci; mitogen-activated protein kinase; multigene family; sequence analysis; Show all 11 Subjects
Abstract:
... The Crippled Growth (CG) cell degeneration of the model ascomycete Podospora anserina (strain S) is controlled by a prion-like element and has been linked to the self-activation of the PaMpk1 MAP kinase cascade. Here, we report on the identification of the “86–11” locus containing twelve genes, ten of which are involved either in setting up the self-activation loop of CG or in inhibiting this loop ...
Nicolau Sbaraini; Chin-Soon Phan; Eden Silva e Souza; Ana Paula A. Perin; Hamideh Rezaee; Felipe Geremia; Matheus da Silva Camargo; Euzébio Guimarães Barbosa; Augusto Schrank; Yit-Heng Chooi; Charley Christian Staats
... Species from the Metarhizium genus are the causal agents of the green muscardine disease of insects. These fungi have been successfully employed for the biological control of pests over decades. Besides the biocontrol applications, recent efforts for genome sequencing of species in this genus have revealed a great diversity of biosynthetic gene clusters potentially associated with secondary metabo ...
microbialgenetics, etc ; Histoplasma; cryptic species; fungi; genetic variation; histoplasmosis; humans; natural selection; phylogeny; population genetics; respiratory tract diseases; virulence; virulent strains; India; Show all 14 Subjects
Abstract:
... Histoplasma, a genus of dimorphic fungi, is the etiological agent of histoplasmosis, a pulmonary disease widespread across the globe. Whole genome sequencing has revealed that the genus harbors a previously unrecognized diversity of cryptic species. To date, studies have focused on Histoplasma isolates collected in the Americas with little knowledge of the genomic variation from other localities. ...
Jessica A. Ferrarezi; Alistair R. McTaggart; Peri A. Tobias; Carolina A.A. Hayashibara; Rebecca M. Degnan; Louise S. Shuey; Livia M. Franceschini; Mariana S. Lopes; Maria C. Quecine
microbialgenetics, etc ; Eucalyptus grandis; Myrtus communis; Puccinia; Sphaerophragmium; Syzygium jambos; biosecurity; genomics; haplotypes; host range; loci; meiosis; mitosis; pheromones; sexual reproduction; teliospores; Show all 16 Subjects
Abstract:
... Austropuccinia psidii is the causal agent of myrtle rust, a fungal disease that infects over 480 species in the Myrtaceae. A. psidii is a biotrophic pathogen that reproduces sexually and asexually. Sexual reproduction has been previously shown on Syzygium jambos and little is known about its reproductive biology on other hosts or whether populations that were formerly structured by host range can ...
... Candida albicans is a common conditional pathogenic fungus in the human body, and its infections have received widespread attention in recent years. Phosphatidylinositol and its derivatives have significant regulatory effects on many physiological processes, such as cell metabolism and growth. In this study, we identified and studied the function of the phosphatidylinositol synthase Pis1 in Candid ...
... C. glabrata is an opportunistic fungal pathogen and the second most common cause of opportunistic fungal infections in humans, that has evolved virulence factors to become a successful pathogen: strong resistance to oxidative stress, capable to adhere and form biofilms in human epithelial cells as well as to abiotic surfaces and high resistance to xenobiotics. Hst1 (a NAD⁺-dependent histone deacet ...
... Microbes constitute the very core of our existence. Long believed to be a nuisance and proponents of various diseases, latest research point toward their functions in processes that can prove beneficial for human survival and afford long-term protection from disease. The wide range of functions exhibited by a host of microbes implies diversity and heterogeneity at the level of the molecular machin ...
... Northern corn leaf blight (NCLB) and sorghum leaf blight (SLB) are significant diseases of maize and sorghum, respectively, caused by the filamentous fungus Setosphaeria turcica. Strains of S. turcica are typically host-specific and infect either maize or sorghum. Host specificity in this pathogen is attributed to a single locus for maize and a second distinct locus for sorghum. To identify the ge ...
... Being found in all eukaryotes investigated, acyl-CoA-binding proteins (ACBPs) participate in lipid metabolism via specifically binding acyl-CoA esters with high affinity. The structures and functions of ACBP family proteins have been extensively described in yeasts, fungi, plants and mammals, but not oomycetes. In the present study, seven ACBP genes named PsACBP1-7 were identified from the genome ...
microbialgenetics, etc ; Fusarium graminearum; Fusarium head blight; conidia; conidiation; cysteine; fungi; gene deletion; gene expression; hydrophobins; hyphae; metabolism; pathogenicity; perithecia; phenotype; rice; sequence analysis; trichothecenes; Show all 18 Subjects
Abstract:
... Fusarium graminearum is the causal agent of Fusarium head blight in cereal crops. As in other filamentous ascomycetes, F. graminearum contains genes encoding putative hydrophobins, which are small secreted amphiphilic proteins with eight conserved cysteine residues. Here, we investigated the roles of all five hydrophobin genes (designated FgHyd1, FgHyd2, FgHyd3, FgHyd4, and FgHyd5) in various myco ...
... This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal ...
... Acetolactate synthase (AHAS) catalyses the first common step in the biosynthesis pathways of three branched-chain amino acids (BCAAs) of valine, isoleucine and leucine. Here, we characterized one regulatory subunit (VdILV6) and three catalytic subunits (VdILV2A, VdILV2B and VdILV2C) of AHAS from the important cotton Verticillium wilt fungus Verticillium dahliae. Phenotypic analysis showed that VdI ...
microbialgenetics, etc ; Aspergillus nidulans; dynein ATPase; interphase; microtubules; Show all 5 Subjects
Abstract:
... Cytoplasmic dynein is a minus end-directed microtubule motor that can be activated by cargo adapters. In Aspergillus nidulans, overexpression of ΔC-HookA, the early endosomal adapter HookA missing its cargo-binding site, causes activated dynein to accumulate at septa and spindle pole bodies (SPBs) where the microtubule-organizing centers are located. Intriguingly, only some interphase nuclei show ...