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1. Versatile approach to densely substituted isoxazolines and pyrazolines: Focus on a quaternary carbon center as a constitutive feature

Author:
Abdelli, Abderrahmen; Gharsa, Haythem; Jmaï, Momtez; Gaucher, Anne; Efrit, Mohamed Lotfi; M'rabet, Hedi; Prim, Damien
Source:
Tetrahedron letters 2020 v.61 no.23 pp. 151958
ISSN:
0040-4039
Subject:
minimum inhibitory concentration,   etc   ; Staphylococcus aureus; antibacterial properties; carbon; chemical structure; cycloaddition reactions; heterocyclic compounds;     Show all 7 Subjects
Abstract:
... A new family of isoxazolines has been obtained via 1,3-dipolar cycloaddition in good to high yields under mild conditions. Our approach focused on construction of the heterocyclic ring and direct access to a quaternary carbon center at position 5. The methodology has also been extended to pyrazoline analogues. The antibacterial activity of these compounds was evaluated, showing specific antibacter ...
DOI:
10.1016/j.tetlet.2020.151958

2. MerP/MerT-mediated mechanism: A different approach to mercury resistance and bioaccumulation by marine bacteria

Author:
Zhang, Jinlong; Zeng, Yiting; Liu, Bing; Deng, Xu
Source:
Journal of hazardous materials 2020 v.388 pp. 122062
ISSN:
0304-3894
Subject:
minimum inhibitory concentration,   etc   ; Pseudomonas pseudoalcaligenes; aquatic bacteria; bioaccumulation; gene expression regulation; genes; mercury; transcriptome;     Show all 8 Subjects
Abstract:
... Currently, mechanism underlying mercury resistance and bioaccumulation of marine bacteria remains little understood. A marine bacterium Pseudomonas pseudoalcaligenes S1 is resistant to 120 mg/L Hg²⁺ with bioaccumulation capacity of 133.33 mg/g. Accordingly, Hg²⁺ resistance and bioaccumulation mechanism of S1 was investigated at molecular and cellular level. Annotation of S1 transcriptome reveals 7 ...
DOI:
10.1016/j.jhazmat.2020.122062

3. Antimicrobial Susceptibility and Multilocus Sequence Typing of Listeria monocytogenes Isolated Over 11 Years from Food, Humans, and the Environment in Italy

Author:
Caruso, Marta; Fraccalvieri, Rosa; Pasquali, Frédérique; Santagada, Gianfranco; Latorre, Laura M.; Difato, Laura M.; Miccolupo, Angela; Normanno, Giovanni; Parisi, Antonio
Source:
Foodborne pathogens & disease 2020 v.17 no.4 pp. 284-294
ISSN:
1556-7125
Subject:
minimum inhibitory concentration,   etc   ; Listeria monocytogenes; antibiotic resistance; ciprofloxacin; clindamycin; monitoring; multilocus sequence typing; oxacillin; serotypes; Italy;     Show all 10 Subjects
Abstract:
... Due to the increasing number of studies reporting the detection of antimicrobial-resistant isolates of Listeria monocytogenes, we sought to determine the antimicrobial susceptibility of L. monocytogenes isolates collected in Italy and find potential correlations to their serotypes and multilocus sequence types (MLST). The antimicrobial susceptibility of 317 L. monocytogenes isolates collected from ...
DOI:
10.1089/fpd.2019.2723

4. Activity of delafloxacin versus that of levofloxacin against anaerobic and microaerophilic isolates

Author:
Boyanova, Lyudmila; Yordanov, Daniel; Ouzounova-Raykova, Vessela; Markovska, Rumyana; Marteva-Proevska, Yulia; Mitov, Ivan
Source:
Anaerobe 2020 v.62 pp. 102150
ISSN:
1075-9964
Subject:
minimum inhibitory concentration,   etc   ; Clostridium; Gram-negative bacteria; Gram-positive bacteria; levofloxacin;     Show all 5 Subjects
Abstract:
... The aim of the study was to comparatively assess delafloxacin and levofloxacin activities against 96 anaerobic and some microaerophilic isolates. Delafloxacin minimal inhibitory concentrations (MICs) were strikingly lower than those of levofloxacin. Delafloxacin MIC₉₀ against clostridia, other Gram-positive rods, anaerobic/microaerophilic cocci and Gram-negative rods were 0.75, 0.032, 0.38 and 0.5 ...
DOI:
10.1016/j.anaerobe.2020.102150

5. Combating Pseudomonas aeruginosa Biofilms by a Chitosan-PEG-Peptide Conjugate via Changes in Assembled Structure

Author:
Ju, Xiaoyan; Chen, Jun; Zhou, Mengxue; Zhu, Meng; Li, Zhuang; Gao, Sijia; Ou, Jinzhao; Xu, Dandan; Wu, Man; Jiang, Shidong; Hu, Yi; Tian, Ye; Niu, Zhongwei
Source:
ACS applied materials & interfaces 2020 v.12 no.12 pp. 13731-13738
ISSN:
1944-8252
Subject:
minimum inhibitory concentration,   etc   ; Pseudomonas aeruginosa; bacteria; biofilm; cell membranes; medical equipment; peptides; polymers; tobramycin;     Show all 9 Subjects
Abstract:
... Pseudomonas aeruginosa (P. aeruginosa) biofilms are associated with a wide range of infections, from chronic tissue diseases to implanted medical devices. In a biofilm, the extracellular polymeric substance (EPS) causes an inhibited penetration of antibacterial agents, leading to a 100–1000 times tolerance of the bacteria. In view of the water-filled channels in biofilms and the highly negative ch ...
DOI:
10.1021/acsami.0c02034

6. Antibacterial activity of griseofulvin analogues as an example of drug repurposing

Author:
Geronikaki, A.; Kartsev, V.; Petrou, A.; Akrivou, M.G.; Vizirianakis, I.S.; Chatzopoulou, F.M.; Lichitsky, B.; Sirakanyan, S.; Kostic, M.; Smiljkovic, M.; Soković, M.; Druzhilovskiy, D.; Poroikov, V.
Source:
International journal of antimicrobial agents 2020 v.55 no.3 pp. 105884
ISSN:
0924-8579
Subject:
minimum inhibitory concentration,   etc   ; ampicillin; antibacterial properties; bacteria; computer simulation; databases; drugs; griseofulvin; prediction; streptomycin;     Show all 10 Subjects
Abstract:
... Griseofulvin is a well-known antifungal drug that was launched in 1962 by Merck & Co. for the treatment of dermatophyte infections. However, according to predictions using the Way2Drug computational drug repurposing platform, it may also have antibacterial activity. As no confirmation of this prediction was found in the published literature, this study estimated in-silico antibacterial activity fo ...
DOI:
10.1016/j.ijantimicag.2020.105884

7. Inactivation kinetics of antibiotic resistant Escherichia coli in secondary wastewater effluents by peracetic and performic acids

Author:
Campo, Neus; De Flora, Cecilia; Maffettone, Roberta; Manoli, Kyriakos; Sarathy, Siva; Santoro, Domenico; Gonzalez-Olmos, Rafael; Auset, Maria
Source:
Water research 2020 v.169 pp. 115227
ISSN:
0043-1354
Subject:
minimum inhibitory concentration,   etc   ; Escherichia coli; ampicillin; antibiotic resistance; disinfection; effluents; fluid mechanics; models; peracetic acid; wastewater;     Show all 10 Subjects
Abstract:
... While disinfection processes have been central for public health protection, new concerns have been raised with respect to their ability to control the spread of antibiotic resistance in the environment. In this study, we report the inactivation kinetics by peracetic and performic acids of a typical indicator, Escherichia coli and its corresponding antibiotic-resistant subpopulation, in secondary ...
DOI:
10.1016/j.watres.2019.115227

8. Assessment of mortality stratified by meropenem minimum inhibitory concentration in patients with Enterobacteriaceae bacteraemia: A patient-level analysis of published data

Author:
O'Donnell, J. Nicholas; Rhodes, Nathaniel J.; Biehle, Lauren R.; Esterly, John S.; Patel, Twisha S.; McLaughlin, Milena M.; Hirsch, Elizabeth B.
Source:
International journal of antimicrobial agents 2020 v.55 no.2 pp. 105849
ISSN:
0924-8579
Subject:
minimum inhibitory concentration,   etc   ; Klebsiella pneumoniae; antibiotic resistance; bacteremia; beta-lactamase; meropenem; mortality; patients; systematic review; therapeutics;     Show all 10 Subjects
Abstract:
... In 2010, the Clinical and Laboratory Standards Institute (CLSI) lowered carbapenem breakpoints to reduce the proportion of ‘susceptible’ organisms that produced carbapenemases. Few studies have evaluated the effect of this change on clinical outcomes. This systematic review aimed to evaluate the effect of carbapenem MICs on 30-day mortality from pooled patient-level data from studies of patients t ...
DOI:
10.1016/j.ijantimicag.2019.11.006

9. Evaluation of the in vitro activity of WCK 5222 (cefepime/zidebactam) and currently available combination therapies against single- and double-carbapenemase producing Enterobacteriaceae: Expanding the zone of hope

Author:
Avery, Lindsay M.; Mullane, Elias M.; Nicolau, David P.
Source:
International journal of antimicrobial agents 2020 v.55 no.2 pp. 105863
ISSN:
0924-8579
Subject:
minimum inhibitory concentration,   etc   ; Enterobacteriaceae; aztreonam; beta-lactamase; ceftazidime; growth retardation; in vivo studies; meropenem;     Show all 8 Subjects
Abstract:
... Cefepime/zidebactam (WCK 5222) is a β-lactam/β-lactam enhancer antibiotic designed to retain in vitro activity against Enterobacteriaceae that simultaneously produce metallo-β-lactamase (MBL) and serine-β-lactamase (SBL). Aztreonam (ATM) plus ceftazidime/avibactam (CZA) or meropenem/vaborbactam (M/V) is an attractive option for coverage of such strains, but clinical laboratories are not equipped t ...
DOI:
10.1016/j.ijantimicag.2019.105863

10. Density-dependent growth response and sensitivity of Meloidogyne incognita to Maerua angolensis and Tabernaemontana elegans: Card model

Author:
Khosa, M. C.; Dube, Z. P.; Tselanyane, M.; Fouche, G.; De Waele, D.; Daneel, M. S.
Source:
Acta agriculturæ Scandinavica 2020 v.70 no.1 pp. 24-30
ISSN:
1651-1913
Subject:
minimum inhibitory concentration,   etc   ; Maerua; Meloidogyne incognita; Tabernaemontana; juveniles; models; mortality; plant extracts;     Show all 8 Subjects
Abstract:
... Curve-fitting Allelochemical Response Dosage (CARD) computer-based model has proven to be a valuable tool in the definition of dosage response relationships between organisms and various plant extracts. Its use in the explanation of the relationship between Maerua angolensis and Tabernaemontana elegans concentrations and Meloidogyne incognita second-stage juvenile (J2) hatch and mortality has not ...
DOI:
10.1080/09064710.2019.1663913

11. A New Antibacterial Chlorinated Amino Acid Derivative from the Sponge-Derived Fungus Aspergillus sp. LS53

Author:
Zhang, Lu; Qiu, Panpan; Ding, Lijian; Li, Qiang; Song, Jingjing; Han, Zhiwen; He, Shan
Source:
Chemistry of natural compounds 2020 v.56 no.1 pp. 109-111
ISSN:
0009-3130
Subject:
minimum inhibitory concentration,   etc   ; Aspergillus; Vibrio harveyi; amino acids; antibacterial properties; chemical structure; fungi; spectral analysis;     Show all 8 Subjects
Abstract:
... A new chlorinated amino acid derivative with a rare 3-chloro-4-hydroxyphenyl unit named aspergamide A (1), along with three known compounds, xylarinol A (2), nectriapyrone (3), and asperisocoumarin A (4), were isolated from the sponge-derived fungus Aspergillus sp. LS53. Their structures were determined by combining detailed spectroscopic analysis and literature data. Compounds 1, 3, and 4 showed ...
DOI:
10.1007/s10600-020-02955-x

12. Antimicrobial susceptibility of bacterial isolates from ambulatory practice and from a referral hospital

Author:
Potier, Julie F. N.; Durham, Andy E.
Source:
Journal of veterinary internal medicine 2020 v.34 no.1 pp. 300-306
ISSN:
0891-6640
Subject:
minimum inhibitory concentration,   etc   ; antibiotic resistance; drugs; gentamicin; horses; hospitals; penicillins; retrospective studies; sulfamethoxazole; trimethoprim;     Show all 10 Subjects
Abstract:
... BACKGROUND: Responsible use of antimicrobials in equine practice relies on knowledge of common bacterial isolates and their antimicrobial sensitivities. OBJECTIVES: To assess the frequency of bacterial resistance to a combination of parenteral penicillin and gentamicin and to trimethoprim and sulfamethoxazole for PO use in a selection of clinical isolates, and subsequently to determine the prevale ...
DOI:
10.1111/jvim.15685
PubMed:
31849110
PubMed Central:
PMC6979268

13. Therapeutic Review: Ceftiofur crystalline free acid

Author:
Hansen, Colin; DiGeronimo, Peter M.
Source:
Journal of exotic pet medicine 2020
ISSN:
1557-5063
Subject:
minimum inhibitory concentration,   etc   ; birds; cattle; ceftiofur; fish; horses; pathogens; pharmacokinetics; reptiles; swine; therapeutics; wild animals;     Show all 12 Subjects
Abstract:
... Ceftiofur crystalline free acid (CCFA) is a long-acting, third generation cephalosporin labeled for use in cattle, pigs, and horses. A number of recent studies have investigated the pharmacokinetics of CCFA in various taxa including non-domestic mammals, birds, reptiles, and fish. This review summarizes the current available literature and provides tables to guide dosing based on the minimum inhib ...
DOI:
10.1053/j.jepm.2020.04.005

14. Evolutionary landscapes of Pseudomonas aeruginosa towards ribosome-targeting antibiotic resistance depend on selection strength

Author:
Sanz-García, Fernando; Sánchez, María Blanca; Hernando-Amado, Sara; Martínez, José Luis
Source:
International journal of antimicrobial agents 2020 v.55 no.6 pp. 105965
ISSN:
0924-8579
Subject:
minimum inhibitory concentration,   etc   ; Pseudomonas aeruginosa; antibiotic resistance; cross resistance; directed evolution; ecosystems; mutants; phenotype; sequence analysis; tigecycline; tobramycin;     Show all 11 Subjects
Abstract:
... It is generally accepted that antibiotic-resistant mutants are selected in a range of concentrations ranging from the minimum inhibitory concentration (MIC) to the mutant preventive concentration. More recently, it has been found that antibiotic-resistant mutants can also be selected at concentrations below MIC, which expands the conditions where this selection may occur. Using experimental evolut ...
DOI:
10.1016/j.ijantimicag.2020.105965

15. Thymol and carvacrol in nanoliposomes: Characterization and a comparison with free counterparts against planktonic and glass-adhered Salmonella

Author:
Heckler, Caroline; Marques Maders Silva, Caroline; Ayres Cacciatore, Fabiola; Daroit, Daniel Joner; da Silva Malheiros, Patrícia
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2020 v.127 pp. 109382
ISSN:
0023-6438
Subject:
minimum inhibitory concentration,   etc   ; Salmonella; anti-infective agents; bacterial adhesion; carvacrol; disinfection; encapsulation; food processing; foods; glass; plankton; thymol; zeta potential;     Show all 13 Subjects
Abstract:
... Nanoliposome-encapsulated and free thymol, carvacrol, and thymol/carvacrol (1:1) were assessed as antimicrobials against a Salmonella pool. Liposome-encapsulated thymol (TL), carvacrol (CL) and thymol/carvacrol (TCL) presented 230–270 nm diameter, satisfactory polydispersity (0.24–0.31), zeta potential of approximately −30 mV and high encapsulation efficiencies (~99%), remaining stable during 28 d ...
DOI:
10.1016/j.lwt.2020.109382

16. Comparison of the recommended colistin susceptibility testing methods with colistin gradient strips and semi-automated method for antimicrobial-resistant non-fermenting rods

Author:
Depka, Dagmara; Mikucka, Agnieszka; Bogiel, Tomasz; Gospodarek-Komkowska, Eugenia
Source:
Journal of microbiological methods 2020 v.172 pp. 105905
ISSN:
0167-7012
Subject:
minimum inhibitory concentration,   etc   ; Acinetobacter baumannii; Pseudomonas aeruginosa; antibiotic resistance; automation; colistin; data analysis; multiple drug resistance; Italy;     Show all 9 Subjects
Abstract:
... An increased frequency of multidrug-resistant non-fermenting rods isolation has resulted in the excessive use of colistin – often the last chance antimicrobial. However, determination of colistin susceptibility is difficult, mainly because of its structure and limited diffusion properties. This study was performed to compare colistin susceptibility testing among Pseudomonas aeruginosa (n = 49) and ...
DOI:
10.1016/j.mimet.2020.105905

17. Eleucanainones A and B: Two Dimeric Structures from the Bulbs of Eleutherine americana with Anti-MRSA Activity

Author:
Chen, Deli; Sun, Zhaocui; Liu, Yangyang; Li, Zongyang; Liang, Hanqiao; Chen, Lei; Xu, Xudong; Yang, Junshan; Ma, Guoxu; Huo, Xiaowei
Source:
Organic letters 2020 v.22 no.9 pp. 3449-3453
ISSN:
1523-7052
Subject:
minimum inhibitory concentration,   etc   ; antibiotic resistance; bulbs; carbon; chemical reactions; chemical structure; dibenzofuran; methicillin; methicillin-resistant Staphylococcus aureus; naphthoquinones; spectroscopy;     Show all 11 Subjects
Abstract:
... Two naphthoquinone-derived heterodimers with unprecedented carbon skeletons, eleucanainones A (1) and B (2), were isolated from the bulbs of Eleutherine americana. Their structures were elucidated by comprehensive spectroscopic methods. The structures of 1 and 2 were determined to be the first examples of dibenzofuran- and naphthalenone-containing naphthoquinone dimers. Compound 1 exhibited signif ...
DOI:
10.1021/acs.orglett.0c00903

18. Inhibition of biofilm formation of Pseudomonas aeruginosa by caffeine: a potential approach for sustainable management of biofilm

Author:
Chakraborty, Poulomi; Dastidar, Debabrata Ghosh; Paul, Payel; Dutta, Sutirtha; Basu, Debajjyoti; Sharma, Senjuti Roy; Basu, Shreosi; Sarker, Ranojit Kumar; Sen, Aparna; Sarkar, Amit; Tribedi, Prosun
Source:
Archives of microbiology 2020 v.202 no.3 pp. 623-635
ISSN:
0302-8933
Subject:
minimum inhibitory concentration,   etc   ; Pseudomonas aeruginosa; antimicrobial properties; bacterial motility; biofilm; caffeine; computer simulation; proteins; quorum sensing; secretion; virulence;     Show all 11 Subjects
Abstract:
... Pseudomonas aeruginosa is a potent biofilm forming organism causing several diseases on host involving biofilm. Several natural and synthetic molecules have been explored towards inhibiting the biofilm formation of Pseudomonas aeruginosa. In the current report, the role of a natural molecule namely caffeine was examined against the biofilm forming ability of P. aeruginosa. We have observed that ca ...
DOI:
10.1007/s00203-019-01775-0

19. Modulation of drug resistance in Staphylococcus aureus by 132-hydroxy-(132-R/S)-pheophytin isolated from Sargassum polyceratium

Author:
Menezes-Silva, Suellen; Lira, Narlize Silva; Mangueira do Nascimento, Yuri; Araújo Ramos Meireles, Roseana; da Silva Dias, Celidarque; Tavares, Josean Fechine; Sobral da Silva, Marcelo; Cavalcanti de Miranda, George Emmanuel; Barbosa Filho, José Maria; Pinto de Siqueira-Junior, José
Source:
Microbial pathogenesis 2020 v.141 pp. 104034
ISSN:
0882-4010
Subject:
minimum inhibitory concentration,   etc   ; Sargassum; Staphylococcus aureus; adjuvants; antibacterial properties; antibiotic resistance; erythromycin; macroalgae; norfloxacin; plasma membrane; synergism; tetracycline; transporters;     Show all 13 Subjects
Abstract:
... Efflux pumps are integral parts of the bacterial plasma membrane that are responsible for many cases of antibiotic resistance. Modulators of drug resistance are regarded as the most suitable new antibacterial therapies. We evaluated the extracts of Sargassum polyceratium and the isolated compound pheophytin (Sp-1) for antibiotic modifying activity in strains of Staphylococcus aureus with efflux pu ...
DOI:
10.1016/j.micpath.2020.104034

20. Antimicrobial peptides against drug resistant Mycobacterium abscessus

Author:
da Silva, Joas L.; Gupta, Shashank; Olivier, Kenneth N.; Zelazny, Adrian M.
Source:
Research in microbiology 2020
ISSN:
0923-2508
Subject:
minimum inhibitory concentration,   etc   ; Acanthamoeba castellanii; Mycobacterium abscessus; anti-infective agents; antimicrobial peptides; hosts; microorganisms; multiple drug resistance;     Show all 8 Subjects
Abstract:
... Mycobacterium abscessus (MAB) comprise rapidly growing, often multidrug-resistant (MDR), nontuberculous mycobacteria responsible for pulmonary and other infections in susceptible hosts. Antimicrobial peptides (APs) are natural and synthetic antimicrobials active against a range of microorganisms including mycobacteria. We evaluated APs activity against MAB reference and clinical strains. We observ ...
DOI:
10.1016/j.resmic.2020.03.001