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1. Histamine H1 receptor antagonists enhance the efficacy of antibacterials against Escherichia coli

Author:
Bruer, G. G.; Hagedorn, P.; Kietzmann, M.; Tohamy, A. F.; Filor, V.; Schultz, E.; Mielke-Kuschow, S.; Meissner, J.
Source:
BMC veterinary research 2019 v.15 no.1 pp. 55
ISSN:
1746-6148
Subject:
minimum inhibitory concentration,   etc   ; Escherichia coli; antagonists; antihistamines; histamine; microorganisms;     Show all 6 Subjects
Abstract:
... BACKGROUND: H₁ receptor antagonists are commonly used for the treatment of allergic diseases. The aim of this study was to find out, if antihistaminic compounds like mepyramine have the ability to influence the activity of antibacterials. Therefore, the checkerboard method was chosen to detect these possible effects in vitro. Studies were performed with two different Escherichia coli (E. coli) str ...
DOI:
10.1186/s12917-019-1797-9

2. Two new cytochalasans from the marine sediment-derived fungus Westerdykella dispersa and their antibacterial activities

Author:
Xu, Dan; Zhang, Xia; Shi, Xiong; Xian, Peng-Jie; Hong, Liu; Tao, Yan-Duo; Yang, Xiao-Long
Source:
Phytochemistry letters 2019 v.32 pp. 52-55
ISSN:
1874-3900
Subject:
minimum inhibitory concentration,   etc   ; antibacterial properties; fermentation; fungi; marine sediments; spectroscopy;     Show all 6 Subjects
Abstract:
... Two new cytochalasans, 16α-methylaspochalasin J (1) and 16-hydroxymethylaspergillin PZ (2), have been characterized from the solid fermentation culture of Westerdykella dispersa isolated from the marine sediments. The structures and relative configurations of 1-2 were elucidated by a combination of spectroscopic methods, as well as by comparison with related known compounds. Compounds 1 and 2 show ...
DOI:
10.1016/j.phytol.2019.05.002

3. FRET probe-based antibacterial susceptibility testing (F-AST) by detection of bacterial nucleases released by antibiotic-induced lysis

Author:
Park, Kyoungsook; Jeong, Jinyoung; Yi, So Yeon; Lee, Wang Sik; Shin, Yong Beom
Source:
Biosensors & bioelectronics 2019 v.130 pp. 225-229
ISSN:
0956-5663
Subject:
minimum inhibitory concentration,   etc   ; biosensors; energy transfer; fluorescence; nucleases; quality control;     Show all 6 Subjects
Abstract:
... This study demonstrates a novel and rapid antibacterial susceptibility testing (AST) method, called fluorescence resonance energy transfer (FRET) probe-based AST (F-AST), which relies on a nuclease-activated FRET probe that detects bacterial nucleases released by antibiotic-induced bacterial lysis. Three quality control (QC) strains and two additional clinically important strains were tested, and ...
DOI:
10.1016/j.bios.2019.01.033

4. Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers

Author:
Rani, Anu; Viljoen, Albertus; Johansen, Matt D.; Kremer, Laurent; Kumar, Vipan
Source:
RSC advances 2019 v.9 no.15 pp. 8515-8528
ISSN:
2046-2069
Subject:
minimum inhibitory concentration,   etc   ; Mycobacterium tuberculosis; cytotoxicity; microwave treatment; pharmacology; piperidines;     Show all 6 Subjects
Abstract:
... A series of secondary amine-substituted isoindoline-1,3-dione-4-aminoquinolines were prepared via microwave heating and assayed for their anti-mycobacterial activities. The compound with a butyl chain as a spacer between the two pharmacophores and piperidine as the secondary amine component on the isoindoline ring was the most potent and non-cytotoxic among the synthesized compounds, exhibiting a ...
DOI:
10.1039/c8ra10532d

5. Characterization of mercury-reducing potential bacteria isolated from Keputih non-active sanitary landfill leachate, Surabaya, Indonesia under different saline conditions

Author:
Imron, Muhammad Fauzul; Kurniawan, Setyo Budi; Soegianto, Agoes
Source:
Journal of environmental management 2019 v.241 pp. 113-122
ISSN:
0301-4797
Subject:
minimum inhibitory concentration,   etc   ; Pseudomonas aeruginosa; adsorbents; bacteria; bioremediation; landfill leachates; landfills; mercury; Indonesia;     Show all 9 Subjects
Abstract:
... The objectives of this research were to identify the capability of bacteria isolated from a non-active sanitary landfill to remove mercury under different saline conditions and to understand the removal kinetics. The mercury concentrations used in the minimum inhibitory concentration (MIC) test were 0, 5, 10, 15 and 20 mg/L. The capability of one selected bacterium from the MIC test to remove merc ...
DOI:
10.1016/j.jenvman.2019.04.017

6. Effect of Helicobacter pylori biofilm formation on susceptibility to amoxicillin, metronidazole and clarithromycin

Author:
Yonezawa, Hideo; Osaki, Takako; Hojo, Fuhito; Kamiya, Shigeru
Source:
Microbial pathogenesis 2019 v.132 pp. 100-108
ISSN:
0882-4010
Subject:
minimum inhibitory concentration,   etc   ; Helicobacter pylori; amoxicillin; biofilm; biomass; clarithromycin; messenger RNA; metronidazole; pathogens; plankton; transporters; viability;     Show all 12 Subjects
Abstract:
... The human gastric pathogen Helicobacter pylori forms biofilms in vitro and in vivo. We previously demonstrated that H. pylori biofilm formation in vitro decreased its susceptibility to clarithromycin (CAM). The aim of this study was to evaluate the effects of biofilm formation on amoxicillin (AMPC) and metronidazole (MNZ) susceptibility. In addition, we assessed the influence of biofilms of CAM re ...
DOI:
10.1016/j.micpath.2019.04.030

7. Kick-starting evolution efficiency with an autonomous evolution mutation system

Author:
Wang, Shihui; Hou, Yaru; Chen, Xiulai; Liu, Liming
Source:
Metabolic engineering 2019 v.54 pp. 127-136
ISSN:
1096-7176
Subject:
minimum inhibitory concentration,   etc   ; Bacillus subtilis; acetoin; directed evolution; evolutionary adaptation; fermenters; mutagens; mutation; phenotype;     Show all 9 Subjects
Abstract:
... Adaptive evolution is an effective strategy to obtain industrial strains with excellent performance, but this method is time-consuming and less efficient. To solve these problems, we constructed an autonomous evolution mutation system (AEMS) to promote the occurrence of mutations, based on the hierarchical dynamic control between the high-fidelity module and the mutagenic module. AEMS was applied ...
DOI:
10.1016/j.ymben.2019.03.010

8. Role of M.tuberculosis protein Rv2005c in the aminoglycosides resistance

Author:
Sharma, Divakar; Lata, Manju; Faheem, Mohammad; Khan, Asad Ullah; Joshi, Beenu; Venkatesan, Krishnamurthy; Shukla, Sangeeta; Bisht, Deepa
Source:
Microbial pathogenesis 2019 v.132 pp. 150-155
ISSN:
0882-4010
Subject:
minimum inhibitory concentration,   etc   ; Mycobacterium tuberculosis; amikacin; drug resistance; drugs; genetic vectors; tuberculosis; virulence;     Show all 8 Subjects
Abstract:
... Tuberculosis is an airborne infectious disease caused by Mycobacterium tuberculosis which threatens the globe. Aminoglycosides {Amikacin (AK) & Kanamycin (KM)} are WHO recommended second-line anti-TB drugs used against the treatment of drug-resistant tuberculosis. Aminoglycosides target the steps of protein translation machinery of M.tuberculosis. Several mechanisms have been put forward to elucid ...
DOI:
10.1016/j.micpath.2019.05.001

9. Ceftaroline fosamil therapy in patients with acute bacterial skin and skin-structure infections with systemic inflammatory signs: A retrospective dose comparison across three pivotal trials

Author:
Corey, G. Ralph; Wilcox, Mark H.; Gonzalez, Jesus; Jandourek, Alena; Wilson, David J.; Friedland, H. David; Das, Shampa; Iaconis, Joseph; Dryden, Matthew
Source:
International journal of antimicrobial agents 2019 v.53 no.6 pp. 830-837
ISSN:
0924-8579
Subject:
minimum inhibitory concentration,   etc   ; anti-infective agents; disease severity; inflammation; pathogens; patients; pharmacokinetics; sepsis (infection); therapeutics;     Show all 9 Subjects
Abstract:
... This post-hoc analysis compared the pharmacokinetics and clinical outcomes of ceftaroline fosamil 600 mg every 12 (q12h) versus every 8 hours (q8h) in patients with acute bacterial skin and skin-structure infection (ABSSSI) and signs of sepsis. Clinical outcomes at test-of-cure in patients with ABSSSI and systemic inflammatory signs/systemic inflammatory response syndrome (SIRS) as well as ceftaro ...
DOI:
10.1016/j.ijantimicag.2019.01.016

10. High prevalence and diversity of tcdA-negative and tcdB-positive, and non-toxigenic, Clostridium difficile in Thailand

Author:
Imwattana, Korakrit; Wangroongsarb, Piyada; Riley, Thomas V.
Source:
Anaerobe 2019 v.57 pp. 4-10
ISSN:
1075-9964
Subject:
minimum inhibitory concentration,   etc   ; Clostridium difficile; fluoroquinolones; genes; hospitals; metronidazole; nontoxigenic strains; pathogenesis; ribotypes; ribotyping; vancomycin; Thailand;     Show all 12 Subjects
Abstract:
... Studies on the prevalence and diversity of Clostridium difficile in Thailand have been limited to those derived from a few tertiary hospitals in Central Thailand. In this study, 145 C. difficile isolates collected in 13 provinces in Thailand during 2006–2018 were characterized by ribotyping and detection of toxin genes. Minimum inhibitory concentrations of eight antimicrobial agents were determine ...
DOI:
10.1016/j.anaerobe.2019.03.008

11. Change in antimicrobial susceptibility and PCR ribotypes of Clostridioides difficile in a hospital over 5 years: Correlation analysis with antimicrobial consumption

Author:
Seo, Mi-Ran; Kim, Bongyoung; Kim, Jieun; Pai, Hyunjoo
Source:
International journal of antimicrobial agents 2019
ISSN:
0924-8579
Subject:
minimum inhibitory concentration,   etc   ; Clostridium difficile; antibiotic resistance; clindamycin; hospitals; metronidazole; moxifloxacin; polymerase chain reaction; ribotypes; vancomycin;     Show all 10 Subjects
Abstract:
... Clostridioides difficile infection (CDI) is a major concern in hospital settings. Antimicrobial resistance is a key contributing factor in CDI outbreaks. This study analysed the antimicrobial susceptibility and PCR ribotypes (RTs) of 745 C. difficile isolates collected at a single institution over 5 years. Seventeen known RTs were identified in 643 isolates (86.3%), of which RTs 018, 017, 015, 001 ...
DOI:
10.1016/j.ijantimicag.2019.05.022

12. Breakpoint to MIC quotient: A parameter to rapidly evaluate the in vitro bactericidal activity of β-lactams on Enterobacteriaceae

Author:
Grillon, Antoine; Chabaud, Angeline; Zambardi, Gilles; Caniaux, Isabelle; Jehl, François
Source:
International journal of antimicrobial agents 2019 v.53 no.5 pp. 674-677
ISSN:
0924-8579
Subject:
minimum inhibitory concentration,   etc   ; Enterobacteriaceae; antibacterial properties; antibiotic resistance; antibiotics; bacterial infections; beta-lactams; pathogens; patients; risk;     Show all 10 Subjects
Abstract:
... Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) do not completely predict the bactericidal nature of the antimicrobial agent. Patients with pathogens having MICs near the clinical breakpoint experience a higher risk of clinical failure. This study defined an indicator, breakpoint to MIC quotient (BMQ), that incorporates MIC and the European Committee on Antimicr ...
DOI:
10.1016/j.ijantimicag.2019.01.013

13. A review on biocide reduced susceptibility due to plasmid‐borne antiseptic‐resistant genes—special notes on pharmaceutical environmental isolates

Author:
Vijayakumar, R.; Sandle, T.
Source:
Journal of applied microbiology 2019 v.126 no.4 pp. 1011-1022
ISSN:
1364-5072
Subject:
minimum inhibitory concentration,   etc   ; antibiotic resistance; antiseptics; biocides; disinfectants; genes; hospitals; issues and policy; microorganisms; pharmaceutical industry;     Show all 10 Subjects
Abstract:
... Biocides (antiseptics and disinfectants) are widely used in hospitals and pharmaceutical industries for contamination control. The emergence of reduced susceptibility to biocides is the major concern and this is caused by various factors, among which plasmid‐mediated resistance is common. Many publications describe the antibiotic resistance and mechanisms in a clinical setting. However, there are ...
DOI:
10.1111/jam.14118

14. Sensitizing of β-lactam resistance by tannic acid in methicillin-resistant S. aureus

Author:
Kırmusaoğlu, Sahra
Source:
World journal of microbiology & biotechnology 2019 v.35 no.4 pp. 57
ISSN:
0959-3993
Subject:
minimum inhibitory concentration,   etc   ; antibiotic resistance; bacteria; hospitals; methicillin; methicillin-resistant Staphylococcus aureus; synergism; tannins; toxicity;     Show all 9 Subjects
Abstract:
... Methicillin-resistant Staphylococcus aureus (MRSA) infections treatment of which is hard and failed, due to being resistant to all types of β-lactams, have been emerged in hospitals and community. Long-term usage of antibiotics and over doses of antibiotics used in the treatment of infections cause bacteria to develop resistance to antibiotics. β-lactams combined with tannic acid can be a good alt ...
DOI:
10.1007/s11274-019-2637-6

15. Total Synthesis and Antibacterial Activity Evaluation of Griseofamine A and 16-epi-Griseofamine A

Author:
Pan, Xuan; Liu, Zhanzhu
Source:
Organic letters 2019 v.21 no.7 pp. 2393-2396
ISSN:
1523-7052
Subject:
minimum inhibitory concentration,   etc   ; Gram-positive bacteria; antibacterial properties; chemical reactions; diastereomers; drug resistance; organic compounds;     Show all 7 Subjects
Abstract:
... The first total synthesis of griseofamine A and its diastereomer, 16-epi-griseofamine A, is described over seven steps with yields of 23% and 7%, respectively. Their antibacterial activities are also disclosed for the first time. Griseofamine A exhibited in vitro activities against a panel of drug-resistant Gram-positive bacteria with minimum inhibitory concentration (MIC) values of 8–16 μg/mL. No ...
DOI:
10.1021/acs.orglett.9b00672

16. Antimicrobial Activity of Selected Antimicrobial Peptides Against Planktonic Culture and Biofilm of Acinetobacter baumannii

Author:
Jaśkiewicz, Maciej; Neubauer, Damian; Kazor, Kamil; Bartoszewska, Sylwia; Kamysz, Wojciech
Source:
Probiotics and antimicrobial proteins 2019 v.11 no.1 pp. 317-324
ISSN:
1867-1306
Subject:
minimum inhibitory concentration,   etc   ; Acinetobacter baumannii; antimicrobial peptides; antimicrobial properties; bacteria; biofilm; cytotoxicity; pathogens; plankton; polystyrenes; therapeutics;     Show all 11 Subjects
Abstract:
... Acinetobacter baumannii is one of the most challenging pathogens, on account of its predisposition to develop resistance leading to severe, difficult-to-treat infections. As these bacteria are more usually isolated from nosocomial infections, the new therapeutic options are demanded. Antimicrobial peptides (AMPs) are compounds likely to find application in the treatment of A. baumannii. These comp ...
DOI:
10.1007/s12602-018-9444-5

17. Exposure of Candida parapsilosis complex to agricultural azoles: An overview of the role of environmental determinants for the development of resistance

Author:
Brilhante, Raimunda Sâmia Nogueira; Alencar, Lucas Pereira de; Bandeira, Silviane Praciano; Sales, Jamille Alencar; Evangelista, Antônio José de Jesus; Serpa, Rosana; Cordeiro, Rossana de Aguiar; Pereira-Neto, Waldemiro de Aquino; Sidrim, José Júlio Costa; Castelo-Branco, Débora de Souza Collares Maia; Rocha, Marcos Fábio Gadelha
Source:
The Science of the total environment 2019 v.650 pp. 1231-1238
ISSN:
0048-9697
Subject:
minimum inhibitory concentration,   etc   ; Candida parapsilosis; biofilm; cryptic species; fluconazole; gene expression; phenotype; tebuconazole; tetraconazole;     Show all 9 Subjects
Abstract:
... This work investigated the phenotypic behavior of Candida parapsilosis species complex in response to exposure to agricultural azoles and fluconazole. Three fluconazole-susceptible strains of C. parapsilosis sensu stricto, C. orthopsilosis and C. metapsilosis were used. Initial minimum inhibitory concentrations (iMICs) for agricultural and clinical azoles were determined by broth microdilution. Th ...
DOI:
10.1016/j.scitotenv.2018.09.096

18. Comparison of Neisseria gonorrhoeae minimum inhibitory concentrations obtained using agar dilution versus microbroth dilution methods

Author:
Jacobson, Rachael K.; Notaro, Marysa J.; Carr, Grant J.
Source:
Journal of microbiological methods 2019 v.157 pp. 93-99
ISSN:
0167-7012
Subject:
minimum inhibitory concentration,   etc   ; Neisseria gonorrhoeae; agar; antibiotic resistance; azithromycin; ceftriaxone; ciprofloxacin; disease transmission;     Show all 8 Subjects
Abstract:
... With increasing antibiotic resistance observed amongst clinical isolates of Neisseria gonorrhoeae, the second most prevalent sexually transmitted bacterial disease in the United States, there is still a need for antimicrobial susceptibility testing (AST). The current method recommended by the Clinical and Laboratory Standards Institute is agar dilution.In this study, we show that a commercially av ...
DOI:
10.1016/j.mimet.2019.01.001

19. Interactions of organic acids with vancomycin‐resistant Enterococcus faecium isolated from community wastewater in Texas

Author:
Beier, R.C.; Harvey, R.B.; Poole, T.L.; Hume, M.E.; Crippen, T.L.; Highfield, L.D.; Alali, W.Q.; Andrews, K.; Anderson, R.C.; Nisbet, D.J.
Source:
Journal of applied microbiology 2019 v.126 no.2 pp. 480-488
ISSN:
1364-5072
Subject:
minimum inhibitory concentration,   etc   ; Enterococcus faecium; disinfection; equations; pH; propionic acid; wastewater; Texas;     Show all 8 Subjects
Abstract:
... AIMS: Investigate the interactions of organic acids (OAs), acetic, butyric, citric, formic, lactic and propionic acid against 50 Gram‐positive vancomycin‐resistant Enterococcus faecium (VRE) strains to determine whether pH, undissociated or dissociated acid forms correlate with bacterial inhibition. METHODS AND RESULTS: Concentrations of undissociated and dissociated OAs at the molar minimum inhib ...
Handle:
10113/6279063
DOI:
10.1111/jam.14145

20. Antibacterial properties and modulation analysis of antibiotic activity of NaCe(MoO4)2 microcrystals

Author:
Moura, J.V.B.; Freitas, T.S.; Cruz, R.P.; Pereira, R.L.S.; Silva, A.R.P.; Santos, A.T.L.; da Silva, J.H.; Luz-Lima, C.; Coutinho, H.D.M.
Source:
Microbial pathogenesis 2019 v.126 pp. 258-262
ISSN:
0882-4010
Subject:
minimum inhibitory concentration,   etc   ; Escherichia coli; Staphylococcus aureus; antibacterial properties; gentamicin; geometry; norfloxacin; synergism;     Show all 8 Subjects
Abstract:
... This study reports the antibacterial properties and modulation analysis of antibiotic activity by NaCe(MoO4)2 microcrystals as well as their structural and morphological characterization. Evaluation of the antibacterial and antibiotic-modulating activity was carried out using the broth microdilution method. The Minimum Inhibitory Concentrations (MICs) of the compounds were expressed as the geometr ...
DOI:
10.1016/j.micpath.2018.11.019