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1. The Minimum Inhibitory Concentration of Antibiotics: Methods, Interpretation, Clinical Relevance

Author:
Kowalska-Krochmal, Beata; Dudek-Wicher, Ruth
Source:
Pathogens 2021 v.10 no.2
ISSN:
2076-0817
Subject:
minimum inhibitory concentration,   etc   ; antibiotics; pharmacokinetics; therapeutics;     Show all 4 Subjects
Abstract:
... Inefficiency of medical therapies used in order to cure patients with bacterial infections requires not only to actively look for new therapeutic strategies but also to carefully select antibiotics based on variety of parameters, including microbiological. Minimal inhibitory concentration (MIC) defines in vitro levels of susceptibility or resistance of specific bacterial strains to applied antibio ...
DOI:
10.3390/pathogens10020165

2. Short communication: Algicide activity of antimicrobial peptides compounds against Prototheca bovis

Author:
Sperotto, V.R.; Denardi, L.B.; Weiblen, C.; de Jesus, F.P.K.; Dorneles, M.R.; Ianiski, L.B.; Santurio, J.M.
Source:
Journal of dairy science 2021 v.104 no.3 pp. 3554-3558
ISSN:
0022-0302
Subject:
minimum inhibitory concentration,   etc   ; Prototheca; algicides; cecropins; dairy science;     Show all 5 Subjects
Abstract:
... This study evaluated the in vitro activity of antimicrobial peptides pexiganan (MSI-78), h-Lf1–11, LL-37, cecropin B, magainin-2, and fengycin B against the veterinary mastitis agent Prototheca bovis. The results showed that pexiganan, h-Lf1–11, LL-37, and cecropin B were able to inhibit the growth and had effect on algicide P. bovis isolates (n = 32). The minimum inhibitory concentration ranged f ...
DOI:
10.3168/jds.2020-18171

3. Abiotic mechanism changing tetracycline resistance in root mucus layer of floating plant: The role of antibiotic-exudate complexation

Author:
Zhang, Ming; Cai, Zhongxia; Zhang, Guofu; Zhang, Daoyong; Pan, Xiangliang
Source:
Journal of hazardous materials 2021 v.416 pp. 125728
ISSN:
0304-3894
Subject:
minimum inhibitory concentration,   etc   ; antibiotic resistance; bacterial communities; chlorides; molecular weight; mucus; rhizosphere; tetracycline;     Show all 8 Subjects
Abstract:
... Antibiotic contamination and antibiotic resistance have caused growing concerns in different aquatic environments. This work investigated the complexation between tetracycline chloride (TCH) and the molecular weight (MW)-fractionated root exudates − the key abiotic mechanism impacting antibiotic fate and antibiotic resistance in rhizosphere. Results show that the affinity of TCH to the high MW exu ...
DOI:
10.1016/j.jhazmat.2021.125728

4. Immobilization of cadmium by Burkholderia sp. QY14 through modified microbially induced phosphate precipitation

Author:
Zeng, Guoquan; Qiao, Suyu; Wang, Xitong; Sheng, Mingping; Wei, Mingyang; Chen, Qun; Xu, Heng; Xu, Fei
Source:
Journal of hazardous materials 2021 v.412 pp. 125156
ISSN:
0304-3894
Subject:
minimum inhibitory concentration,   etc   ; Burkholderia ambifaria; acid phosphatase; agricultural soils; bacteria; bioremediation; cadmium; calcium; hydroxyapatite; mineralization; pH;     Show all 11 Subjects
Abstract:
... Microbially induced phosphate precipitation (MIPP) is an advanced bioremediation technology to immobilize heavy metals. An indigenous bacterium QY14 with the function of mineralization isolated from Cd contaminated farmland soil was identified as Burkholderia ambifaria. The minimum inhibitory concentration value for QY14 was 550 mg/L for soluble Cd concentration. This study found that the addition ...
DOI:
10.1016/j.jhazmat.2021.125156

5. Efficacy of subcutaneous implants to provide continuous plasma terbinafine in hellbenders (cryptobranchus alleganiensi) for future prophylactic use against chytridiomycosis

Author:
Hardman, Rebecca H.; Cox, Sherry; Reinsch, Sherri Doro; Schwartz, Heather Coarsey; Skeba, Sandy; McGinnity, Dale; Souza, Marcy J.; Miller, Debra L.
Source:
Journal of zoo and wildlife medicine 2021 v.52 no.1 pp. 300-305
ISSN:
1937-2825
Subject:
minimum inhibitory concentration,   etc   ; Batrachochytrium dendrobatidis; disease prevention; fungi; humans; juveniles; medicine; mortality; pathogens; wildlife; zoos;     Show all 11 Subjects
Abstract:
... Batrachochytrium dendrobatidis (Bd) is an important fungal pathogen present in wild hellbender (Cryptobranchus alleganiensis) populations that appears to cause disease during novel exposure and acute stress. Hellbender repatriation efforts are ongoing to combat declining populations, but mortality by chytridiomycosis (disease from Bd) after release has been reported. The goal was to determine whet ...
DOI:
10.1638/2020-0158

6. Evaluation of MBT STAR-Cepha and MBT STAR-Carba kits for the detection of extended-spectrum β-lactamases and carbapenemase producing microorganisms using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

Author:
Ota, Yusuke; Furuhashi, Kazuki; Hirai, Nachi; Ishikawa, Jinko; Nagura, Osanori; Yamanaka, Katsumasa; Maekawa, Masato
Source:
Journal of microbiological methods 2021 v.183 pp. 106166
ISSN:
0167-7012
Subject:
minimum inhibitory concentration,   etc   ; antibiotic resistance; beta-lactamase; cephalosporins; desorption; diagnostic techniques; disease control;     Show all 7 Subjects
Abstract:
... Rapid and simple detection of extended-spectrum β-lactamase (ESBL) and carbapenemase is essential for antimicrobial treatment and infection control. Recently, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)-based MBT STAR-Cepha and MBT STAR-Carba kits have been developed with simplified MBT STAR-BL operations. However, the utility of these kits has not b ...
DOI:
10.1016/j.mimet.2021.106166

7. Identification of Eltrombopag as a Repurposing Drug Against Staphylococcus epidermidis and its Biofilms

Author:
Zhu, Juan; She, Pengfei; Fu, Juhua; Peng, Canhui; Wu, Yong
Source:
Current microbiology 2021 v.78 no.4 pp. 1159-1167
ISSN:
0343-8651
Subject:
minimum inhibitory concentration,   etc   ; Staphylococcus epidermidis; agonists; biofilm; cross infection; mammals; microbiology; plankton; thrombopoietin; toxicity; vancomycin;     Show all 11 Subjects
Abstract:
... Staphylococcus epidermidis is a common cause of nosocomial infections, and readily adheres to medical apparatus to form biofilms consisting of highly resistant persister cells. Owing to the refractory infections caused by S. epidermidis biofilms and persisters in immunosuppressed patients, it is crucial to develop new antimicrobials. In the present study, we analyzed the antimicrobial effects of t ...
DOI:
10.1007/s00284-021-02386-z

8. Inhibition of Listeria monocytogenes by the Staphylococcus capitis - derived bacteriocin capidermicin

Author:
Lynch, David; Hill, Colin; Field, Des; Begley, Máire
Source:
Food microbiology 2021 v.94 pp. 103661
ISSN:
0740-0020
Subject:
minimum inhibitory concentration,   etc   ; Listeria monocytogenes; Staphylococcus capitis; antagonism; biofilm; chocolate milk; cottage cheese; lantibiotics; nisin;     Show all 9 Subjects
Abstract:
... Natural methods to control food pathogens are required and bacteriocins have received much interest in this regard. The aim of this study was to investigate the ability of the novel bacteriocin capidermicin to inhibit Listeria monocytogenes. Agar-based deferred antagonism assays were carried out with the capidermicin producer against 17 L. monocytogenes strains and large zones of inhibition were o ...
DOI:
10.1016/j.fm.2020.103661

9. Pharmacokinetics and Pharmacodynamics of Ceftolozane/Tazobactam in Critically Ill Patients With Augmented Renal Clearance

Author:
Nicolau, David P.; De Waele, Jan; Kuti, Joseph L.; Caro, Luzelena; Larson, Kajal B.; Yu, Brian; Gadzicki, Elaine; Zeng, Zhen; Rhee, Elizabeth G.; Rizk, Matthew L.
Source:
International journal of antimicrobial agents 2021 v.57 no.4 pp. 106299
ISSN:
0924-8579
Subject:
minimum inhibitory concentration,   etc   ; creatinine; drugs; intravenous injection; pharmacodynamics; pharmacokinetics; renal clearance;     Show all 7 Subjects
Abstract:
... To determine whether established ceftolozane/tazobactam (C/T) dosing is adequate for patients with augmented renal clearance (ARC) and bacterial infection.ARC (creatinine clearance [CrCl] ≥ 130 mL/min) was confirmed by directly measured CrCl in 11 critically ill patients in a phase 1 pharmacokinetics study. Patients received 3 g C/T (ceftolozane 2 g/tazobactam 1 g) as a 60-minute intravenous infus ...
DOI:
10.1016/j.ijantimicag.2021.106299

10. Sesquiterpene derivatives from Ocotea minarum leaves

Author:
Nogueira, Cláudio Rodrigo; Carbonezi, Lidilhone Hamerski; de Oliveira, Caroline Tieppo Flores; Garcez, Walmir Silva; Garcez, Fernanda Rodrigues
Source:
Phytochemistry letters 2021 v.42 pp. 8-14
ISSN:
1874-3900
Subject:
minimum inhibitory concentration,   etc   ; Candida; Cryptococcus neoformans; Ocotea; chemical structure; leaves; plant biochemistry; sesquiterpenoids; strains;     Show all 9 Subjects
Abstract:
... (+)-β-Sesquiphellandrene-12-oic acid (1) and 4-oxo-lanceolic acid (3), two new bisabolane derivatives; (+)-2-methyl-6[4-oxo-2-cyclohexen-1-yl]-2-(E)-heptenoic acid (4), a new nor-bisabolane derivative; (+)-(E)-exo-α-bergamoten-12-oic acid (5), a new bergamotene-type sesquiterpene; (2E,6E)-2,6-dimethyl-10-methylene-dodecatrienoic acid (6), a farnesene-type sesquiterpene reported for the first time ...
DOI:
10.1016/j.phytol.2021.01.004

11. Diffusion–Convection Hybrid Microfluidic Platform for Rapid Antibiotic Susceptibility Testing

Author:
Nguyen, Ann V.; Azizi, Morteza; Yaghoobi, Mohammad; Dogan, Belgin; Zhang, Shiying; Simpson, Kenneth W.; Abbaspourrad, Alireza
Source:
Analytical chemistry 2021 v.93 no.14 pp. 5789-5796
ISSN:
1520-6882
Subject:
minimum inhibitory concentration,   etc   ; analytical chemistry; antibiotic resistance; antibiotics; convection; culture media; equations; fluorescence; humans; metabolism; streams;     Show all 11 Subjects
Abstract:
... Conventional antibiotic susceptibility testing (AST) assays such as broth microdilution and Kirby–Bauer disk diffusion are time-consuming (e.g., 24–72 h) and labor-intensive. Here, we present a microfluidic platform to perform AST assays with a broad range of antibiotic concentrations and controls. A culture medium stream was serially enriched with antibiotics along the length of the platform via ...
DOI:
10.1021/acs.analchem.0c05248

12. Evaluation of the Ecological Potential of Microorganisms for Purifying Water with High Iron Content

Author:
Pleshakova, Ekaterina; Ngun, Clement; Reshetnikov, Mikhail; Larionov, Maxim Viktorovich
Source:
Water 2021 v.13 no.7
ISSN:
2073-4441
Subject:
minimum inhibitory concentration,   etc   ; Bacillus megaterium; biomass; inoculum; liquids; magnetism; metal tolerance; soil; water; water purification;     Show all 10 Subjects
Abstract:
... The ability of a number of microorganisms isolated from highly magnetic soil of the city Mednogorsk to oxidize Fe (II) under conditions of periodic cultivation in a liquid medium was studied. Among the studied microorganisms, two microbial isolates with maximum growth characteristics and iron-oxidizing activity were selected and identified: Bacillus megaterium 69.3 and B. megaterium 69.5. Individu ...
DOI:
10.3390/w13070901

13. Synthesis and characterization of cotton-silver-graphene quantum dots (cotton/Ag/GQDs) nanocomposite as a new antibacterial nanopad

Author:
Teymourinia, Hakimeh; Amiri, Omid; Salavati-Niasari, Masoud
Source:
Chemosphere 2021 v.267 pp. 129293
ISSN:
0045-6535
Subject:
minimum inhibitory concentration,   etc   ; Escherichia coli; antibacterial properties; antibiotic resistance; cotton; graphene; immunosuppression; nanocomposites; nanosilver; reducing agents;     Show all 10 Subjects
Abstract:
... Appearance of antibiotic resistance in bacteria is a convoluted topic, particularly in treating pestiferous immunodeficiency correlated diseases. The main objective of the current research is to fabricate antibacterial pads by utilizing of graphene quantum dots (GQDs) as a linker, stabilizing, and reduction agent of in situ synthesized Ag nanoparticles (Ag NPs) on cotton pad. Five different antiba ...
DOI:
10.1016/j.chemosphere.2020.129293

14. The pharmacokinetic/pharmacodynamic paradigm for antimicrobial drugs in veterinary medicine: Recent advances and critical appraisal

Author:
Toutain, Pierre‐Louis; Pelligand, Ludovic; Lees, Peter; Bousquet‐Mélou, Alain; Ferran, Aude A.; Turnidge, John D.
Source:
Journal of veterinary pharmacology and therapeutics 2021 v.44 no.2 pp. 172-200
ISSN:
0140-7783
Subject:
minimum inhibitory concentration,   etc   ; animals; antibiotic resistance; drugs; pharmacodynamics; pharmacokinetics; therapeutics; veterinary medicine;     Show all 8 Subjects
Abstract:
... Pharmacokinetic/pharmacodynamic (PK/PD) modelling is the initial step in the semi‐mechanistic approach for optimizing dosage regimens for systemically acting antimicrobial drugs (AMDs). Numerical values of PK/PD indices are used to predict dose and dosing interval on a rational basis followed by confirmation in clinical trials. The value of PK/PD indices lies in their universal applicability among ...
DOI:
10.1111/jvp.12917

15. Dryocrassin ABBA ameliorates Streptococcus pneumoniae-induced infection in vitro through inhibiting Streptococcus pneumoniae growth and neutralizing pneumolysin activity

Author:
Lv, Hongfa; Fang, Tianqi; Kong, Fanrong; Wang, Jianfeng; Deng, Xuming; Yu, Qinlei; Sun, Meiyang; Liang, Xiaoying
Source:
Microbial pathogenesis 2021 v.150 pp. 104683
ISSN:
0882-4010
Subject:
minimum inhibitory concentration,   etc   ; Streptococcus pneumoniae; antibacterial properties; cytotoxicity; growth curves; hemolysis; oligomerization; pathogenesis; pneumolysin; toxicity testing;     Show all 10 Subjects
Abstract:
... To explore the role of dryocrassin ABBA (ABBA) in the prevention and treatment of Streptococcus pneumoniae (S. pneumoniae) infections in vitro, a minimal inhibitory concentration test, growth curve assay, hemolysis assay, BacLight LIVE/DEAD staining experiments, oligomerization inhibition assay, time-killing test, LDH release detection assay and cytotoxicity test were performed to evaluate the eff ...
DOI:
10.1016/j.micpath.2020.104683

16. Potent inhibitory activity of taniborbactam towards NDM-1 and NDM-1Q119X mutants, and in vitro activity of cefepime/taniborbactam against MBLs producing Enterobacterales

Author:
Piccirilli, Alessandra; Segatore, Bernardetta; Brisdelli, Fabrizia; Amicosante, Gianfranco; Perilli, Mariagrazia
Source:
International journal of antimicrobial agents 2021 v.57 no.1 pp. 106228
ISSN:
0924-8579
Subject:
minimum inhibitory concentration,   etc   ; Escherichia coli; anti-infective agents; antibacterial properties; assays; enzymes; laboratories; mutants; phenotype; strains;     Show all 10 Subjects
Abstract:
... Objective: This study aimed to investigate the in vitro activity of taniborbactam (VNRX-5133), a novel broad-spectrum bicyclic boronate, against NDM-1 and Q119E, Q119K, Q119C, Q119F, Q119V, and Q119Y NDM-1 variants, which showed an increased activity towards some β-lactams, including cefepime.Methods: Inhibition kinetic assays were spectrophotometrically performed using cefepime (50 μM) as the rep ...
DOI:
10.1016/j.ijantimicag.2020.106228

17. Evaluation of Teicoplanin Resistance Detected by Automated System in Coagulase Negative Staphylococci: A Comparison with Gradient Test and Broth Microdilution Methods

Author:
Barış, Ayşe; Malkoçoğlu, Gülşah; Büyükyanbolu, Ecem; Aslan, Feride Merve; Bayraktar, Banu; Aktaş, Elif
Source:
Current microbiology 2020 v.77 no.11 pp. 3355-3360
ISSN:
0343-8651
Subject:
minimum inhibitory concentration,   etc   ; antibiotic resistance; automation; microbiology;     Show all 4 Subjects
Abstract:
... Upon the observation of an increase in teicoplanin resistance rates in coagulase negative staphylococci (CoNS) isolates determined by the automated system, we aimed to compare the automated system and gradient test methods with the gold standard broth microdilution method. In addition, the effect of standard antimicrobial susceptibility guidelines on teicoplanin susceptibility test results in CoNS ...
DOI:
10.1007/s00284-020-02144-7

18. Modified bone char with C–MgO as a green antibacterial household water treatment filter: Comparing the microbial quality with refrigerator cartridge filters

Author:
Dayari, Ali Reza; Asgari, Ghorban; Seid-mohammadi, Abdolmotaleb; Samarghandi, Mohammad Reza
Source:
Journal of hazardous materials 2021 v.414 pp. 125516
ISSN:
0304-3894
Subject:
minimum inhibitory concentration,   etc   ; Enterococcus faecalis; Escherichia coli; antibiotics; carbon; coprecipitation; microbiological quality; plate count; refrigerators; sucrose; water treatment;     Show all 11 Subjects
Abstract:
... The present study examines the efficiency of modified bone char (BC) with C–MgO nanoparticles (MBC-C–MgO) as media in a cartridge filter as an antibacterial agent to produce a new filter. The filters were operated in a continuous mode using a pre-static pump. MBC-C–MgO were produced and modified with sucrose through the co-precipitation method. The microbial quality of effluent water samples was c ...
DOI:
10.1016/j.jhazmat.2021.125516

19. ε-Polylysine-coated liposomes loaded with a β-CD inclusion complex loaded with carvacrol: Preparation, characterization, and antibacterial activities

Author:
Rao, Sheng-qi; Sun, Mei-ling; Hu, Yuan; Zheng, Xiang-feng; Yang, Zhen-quan; Jiao, Xin-an
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2021 v.146 pp. 111422
ISSN:
0023-6438
Subject:
minimum inhibitory concentration,   etc   ; Escherichia coli; Staphylococcus aureus; antibacterial properties; bacterial growth; carvacrol; encapsulation; freeze drying; particle size;     Show all 9 Subjects
Abstract:
... In this study, carvacrol (Car) is first embedded in β-cyclodextrin (β-CD) by the freeze-drying method to form the β-cyclodextrin-Carvacrol inclusion compound (β-CD-Car), and then β-CD-Car liposomes (β-CD-Car-Lip) and β-CD-Car liposomes coated with ε-polylysine (ε-PL/β-CD-Car-Lip) with different concentrations (0–20 mg/mL) of β-CD-Car were prepared. The liposomes were characterized, and their physi ...
DOI:
10.1016/j.lwt.2021.111422

20. TLC directed isolation and in silico analysis of antimicrobial metabolite from Nigrospora sphaerica inhabiting Croton bonplandianus Baill

Author:
Chandra Mohana, N.; Rakshith, D.; Ramesha, K.P.; Nuthan, B.R.; Harini, B.P.; Satish, S.
Source:
South African journal of botany 2021 v.139 pp. 106-113
ISSN:
0254-6299
Subject:
minimum inhibitory concentration,   etc   ; Croton bonplandianus; Escherichia coli; Nigrospora; botany; computer simulation; culture media; humans; oxidoreductases; secondary metabolites; spectroscopy;     Show all 11 Subjects
Abstract:
... TLC-bioautography amalgamated with hyphenated spectroscopy aid in precise in situ detection of secondary metabolites with pharmaceutical significance. TLC bioautography offers efficient and economical strategy in identifying compounds of interest from crude extracts. The present investigation has been focused on detection of antimicrobial metabolite from the culture broth of Nigrospora sphaerica i ...
DOI:
10.1016/j.sajb.2021.01.035