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minimuminhibitoryconcentration, etc ; Streptococcus mutans; chlorhexidine; dental caries; hydrophobicity; operon; Show all 6 Subjects
Abstract:
... Chlorhexidine (CHX) is considered to be the gold standard for dental caries prevention and is widely applied in dental practice. However, the long-term application of CHX may result in CHX-resistance in oral pathogens. The aim of this study was to investigate whether long-term use of CHX causes resistance in Streptococcus mutans and to explore the possible associated mechanisms. Four different S. ...
minimuminhibitoryconcentration, etc ; Staphylococcus aureus; bacterial growth; ceftriaxone; inoculum; models; pharmacodynamics; Show all 7 Subjects
Abstract:
... Ceftriaxone is a broad-spectrum cephalosporin that may be one option to treat methicillin-susceptible Staphylococcus aureus (MSSA). Although MSSA may be susceptible to ceftriaxone, the minimum inhibitory concentration (MIC) is generally two- to four-fold higher than other susceptible bacterial pathogens. This study aimed to explore the pharmacodynamics of ceftriaxone against MSSA and to determine ...
minimuminhibitoryconcentration, etc ; Shigella flexneri; antibacterial properties; bacteriocins; biofilm; deformation; phenyllactic acid; plankton; Show all 8 Subjects
Abstract:
... This study investigated antibacterial and antibiofilm activity of the combined use of phenyllactic acid (PLA) and bacteriocin XJS01 against Shigella flexneri_14. The minimum inhibitory concentration (MIC) of PLA and XJS01 against S. flexneri_14 was 2.45 mg/mL and 18.75 μg/mL, respectively. Growth and kill kinetics assays showed that the combined use of 1/2MIC PLA plus 1/2MIC XJS01 had a better act ...
minimuminhibitoryconcentration, etc ; Pseudomonas aeruginosa; Staphylococcus aureus; antimicrobial properties; corrosion; green chemistry; silver; Show all 7 Subjects
Abstract:
... We synthesized nanostructured AgNbO₃ silver perovskite oxide, which prevents the proliferation of microbial cells without undergoing corrosion. The compound was tested for antimicrobial activity against Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa. We confirmed that the antimicrobial activity of the compound was not related to its high dielectric and piezoelectric p ...
minimuminhibitoryconcentration, etc ; benzalkonium chloride; biocides; chlorhexidine; computer software; laboratory experimentation; quality control; solubility; Show all 8 Subjects
Abstract:
... Every laboratory test needs validation by quality controls. For biocide susceptibility testing (BST), neither quality control (QC) strains nor QC ranges applicable to these strains are currently available. As QC strains, four well-defined laboratory reference strains (Staphylococcus aureus ATCC® 6538, Enterococcus hirae ATCC® 10541, Escherichia coli ATCC® 10536 and Pseudomonas aeruginosa ATCC® 154 ...
minimuminhibitoryconcentration, etc ; Fucus; Streptomyces; agar; atomic absorption spectrometry; endophytes; inoculum; metal tolerance; seawater; Show all 9 Subjects
Abstract:
... Heavy metal resistance (Cu, Zn, Fe, Cr, Pb, Cd) and removal capacities of 19 selected actinobacteria strains were performed in order to investigate their applicability as bioremediators for polluted areas. Streptomyces sp. WR1L1S8 was used in the present investigation as heavy metals removing strain, which was isolated from inner tissu of the marine brown algae Fucus sp., and identified based on p ...
Amrita Bharat; Aaron Petkau; Brent P. Avery; Jessica C. Chen; Jason P. Folster; Carolee A. Carson; Ashley Kearney; Celine Nadon; Philip Mabon; Jeffrey Thiessen; David C. Alexander; Vanessa Allen; Sameh El Bailey; Sadjia Bekal; Greg J. German; David Haldane; Linda Hoang; Linda Chui; Jessica Minion; George Zahariadis; Gary Van Domselaar; Richard J. Reid-Smith; Michael R. Mulvey
minimuminhibitoryconcentration, etc ; Salmonella enterica; antibiotic resistance; computer simulation; epidemiology; gentamicin; humans; phenotype; prediction; Canada; Show all 10 Subjects
Abstract:
... Whole genome sequencing (WGS) of Salmonella supports both molecular typing and detection of antimicrobial resistance (AMR). Here, we evaluated the correlation between phenotypic antimicrobial susceptibility testing (AST) and in silico prediction of AMR from WGS in Salmonella enterica (n = 1321) isolated from human infections in Canada. Phenotypic AMR results from broth microdilution testing were u ...
minimuminhibitoryconcentration, etc ; Staphylococcus aureus; citronellal; dose response; enterotoxins; exotoxins; food industry; hemolysins; hemolysis; pork; Show all 10 Subjects
Abstract:
... Staphylococcus aureus (S. aureus) is known to be one of the most common foodborne pathogens capable of secreting a wide range of exotoxins such as enterotoxin, which severely threatens the health of consumers. Over the past few years, the development of safe and effective strategies in inhibiting the growth and enterotoxins generation of S. aureus in food turns out to be the research focus and emp ...
Victor Juno Alencar Fonseca; Ana Lays Braga; Ray Silva de Almeida; Taís Gusmão da Silva; Josefa Carolaine Pereira da Silva; Luciene Ferreira de Lima; Maria Helena Cruz dos Santos; Romério Rodrigues dos Santos Silva; Claudener Souza Teixeira; Henrique Douglas Melo Coutinho; Maria Flaviana Bezerra Morais-Braga
minimuminhibitoryconcentration, etc ; Canavalia ensiformis; Canavalia rosea; Candida albicans; Candida tropicalis; antifungal properties; fluconazole; plankton; Show all 8 Subjects
Abstract:
... Lectins participate in the defense against microorganisms and in signaling the damage caused by pathogens to the cell surface and/or intracellular in plants. This study aims to analyze the antifungal potential of lectins extracted from seeds of Canavalia ensiformis (L.) DC and Canavalia rosea (Sw.) DC, against Candida albicans and Candida tropicalis. The antimicrobial tests were performed by micro ...
minimuminhibitoryconcentration, etc ; antibacterial properties; drug resistance; enrofloxacin; models; mutants; pathogenicity; pharmacodynamics; pharmacokinetics; therapeutics; tryptones; Show all 11 Subjects
Abstract:
... A pharmacokinetic/pharmacodynamic (PK/PD) model was developed to optimize the dosing regimen of enrofloxacin (EN) against Glaesserella parasuis in pigs. EN (2.5 mg/kg) was administered intramuscularly to eight healthy pigs and eight pigs that were experimentally infected with G. parasuis SW124. Blood samples were collected at predetermined time points. Plasma EN concentrations were determined, and ...
minimuminhibitoryconcentration, etc ; Colletotrichum lindemuthianum; anthracnose; azoles; beans; computer simulation; fungi; squalene monooxygenase; synthesis; thiophanate-methyl; Show all 10 Subjects
Abstract:
... BACKGROUND: Anthracnose, caused by the fungus Colletotrichum lindemuthianum, increases losses in the production of common beans. As 1,3‐diazoles can act against fungi by inhibiting the enzyme squalene epoxidase (SE), 2‐aminoselenazoles and 2‐aminothiazoles were synthesized and subjected to tests with the fungus. In addition, the interactions of the most promising substances with the enzyme SE were ...
minimuminhibitoryconcentration, etc ; Canarium schweinfurthii; Salmonella Enteritidis; Salmonella Typhi; Salmonella Typhimurium; bark; mass spectrometry; research; triterpenoids; Show all 9 Subjects
Abstract:
... One new tirucallane triterpene named as canarimoic acid (1), and three known analogues: 3β-hydroxytirucalla-8,24-dien-21-oic acid (2), 3α-acetyltirucalla-8,24-diene-21oic acid (3) and 3-oxotirucalla-8,24-dien-21-oic (4) were isolated from the hydro-ethanolic crude extract of Canarium schweinfurthii. Their structures were established by extensive analysis of 1 D and 2 D NMR data in conjunction with ...
... With the aim of exploring the potential application of a novel chitosan oligosaccharide derivative (COS‐All‐Tio) in shrimp preservation, six dominant spoilage bacteria in the spoiled shrimp (Penaeus vannamei) were isolated and identified as Shewanella putrefaciens (RMS1), S. putrefaciens (S2), Pseudomonas weihenstephanensis (P1), P. gessardii (P2), Aeromonas bestiarum (A1) and Aeromonas molluscoru ...
... In this work, the antibacterial activity and mechanism of chloroform fraction obtained from aqueous extract of mugwort leaves against Staphylococcus aureus were investigated. The extract showed obvious antibacterial activity against S. aureus which the minimum inhibitory concentration and minimum bactericidal concentration were determined to be 3·0 and 6·0 mg ml⁻¹ respectively. The mechanism study ...
... Limonene can inhibit the common spoilage fungi in food, but few studies elucidated its antifungal activity and mechanism against Candida tropicalis to date. Therefore, this study aimed to the antifungal activity and mechanism of d-limonene against C. tropicalis. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of d-limonene against C. tropicalis were 20 μL/mL a ...
Angela Aparecida da Silva; Julio Cesar Polonio; Aline Maria Bulla; Andressa Domingos Polli; Juliana Cristina Castro; Lilian Capelari Soares; Verci Alves de Oliveira-Junior; Veronica Elisa Pimenta Vicentini; Arildo José Braz de Oliveira; José Eduardo Gonçalves; Regina Aparecida Correia Gonçalves; João Lúcio Azevedo; Benício Alves de Abreu-Filho; João Alencar Pamphile
... This study was to evaluate the biological activity of the extract of Botryosphaeria fabicerciana isolated from leaves of Morus nigra. The volatile compounds from the crude extract were analysed by GC-MS which demonstrate that mellein and β-orcinaldehyde were are the major compounds. The best minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extract was obse ...
minimuminhibitoryconcentration, etc ; agar; antibiotic resistance; daptomycin; genes; genotyping; methicillin-resistant Staphylococcus aureus; monitoring; tigecycline; vancomycin; Taiwan; Show all 11 Subjects
Abstract:
... Correlation of antimicrobial susceptibility patterns with particular spa types could help physicians select appropriate antibiotics for the treatment of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections. The aim of this study was to investigate invasive MRSA isolates through delineating the molecular typing results and correlating them with antibiotic susceptibility testing re ...
... Poly (vinyl alcohol) (PVA) films with high transparency, UV-barrier, antioxidant, and antimicrobial properties were prepared using oregano essential oil (OEO) and cinnamon essential oil (CEO) Pickering emulsions. The effect of Pickering emulsion type and concentration on the PVA film properties was studied. Cellulose nanocrystals (CNCs) were used as a natural stabilizer to prepare OEO and CEO Pick ...
minimuminhibitoryconcentration, etc ; Monte Carlo method; beta-lactamase; cefoperazone; computer software; pharmacodynamics; pharmacokinetics; probability; sulbactam; therapeutics; toxicity; Show all 11 Subjects
Abstract:
... Pediatric sepsis syndrome is one of the most common reasons for pediatric intensive care unit hospitalization (PICU). Cefoperazone/sulbactam is a time-dependent beta-lactamase inhibitor combination which has been widely used in the treatment of sepsis. But the pharmacokinetic (PK) and pharmacodynamic (PD) data of cefoperazone/sulbactam are unknown in children with sepsis. The present work aimed to ...
... Amphotericin B (AMB) is a gold standard antifungal drug because of its broad-spectrum activity toward pathogenic yeasts and molds. Because of its low solubility in water and toxicity toward humans, several lipid-based formulations that either increase the aqueous solubility or decrease the side effects have been employed in practical use. In our previous research, we found that the combination of ...