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You searched for: Subject "mitogen-activated protein kinase" Remove constraint Subject: "mitogen-activated protein kinase"
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1. Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo

Author:
Jixuan Ma; Yujia Xie; Yiju Xu; Pei Gu; Yingdie Zhang; Lieyang Fan; Yun Zhou; Haijiao Wang; Ting Zhou; Jintong He; Dongming Wang; Weihong Chen
Source:
Journal of environmental sciences (China) 2023 v.126 pp. 772-783
ISSN:
1001-0742
Subject:
mitogen-activated protein kinase,   etc   ; antibodies; collagen; environmental exposure; epithelium; fibroblasts; fibrosis; gelatinase A; glycoproteins; inflammation; interleukin-11; interleukin-6; lungs; mice; necrosis; neoplasms; neutralization; silica; therapeutics; China;     Show all 20 Subjects
Abstract:
... Environmental exposure to crystalline silica particles can lead to silicosis, which is one of the most serious pulmonary interstitial fibrosis around the world. Unfortunately, the exact mechanism on silicosis is unclear, and the effective treatments are lacking to date. In this study, we aim to explore the molecular mechanism by which interleukin-11 (IL-11) affects silica particles-induced lung in ...
DOI:
10.1016/j.jes.2022.03.015

2. Preserved egg white alleviates DSS-induced colitis in mice through the reduction of oxidative stress, modulation of infl ammatory cytokines, NF-κB, MAPK and gut microbiota composition

Author:
Lingyu Li; Ning Qiu; Yaqi Meng; Chenyan Wang; Yoshinori Mine; Russell Keast; Vincent Guyonnet
Source:
Food science and human wellness 2023 v.12 no.1 pp. 312-323
ISSN:
2213-4530
Subject:
mitogen-activated protein kinase,   etc   ; Lachnospiraceae; Proteobacteria; Ruminococcaceae; colitis; colon; cytokines; dextran sulfate; egg albumen; eggs; food science; gene expression; humans; intestinal microorganisms; myeloperoxidase; oxidative stress; phosphorylation; secretion; transcription factor NF-kappa B;     Show all 19 Subjects
Abstract:
... Traditional Chinese preserved egg products have exhibited some anti-inflammatory effects, but their mechanisms of action remain unknown. This study aimed to investigate the anti-inflammatory effects of preserved egg white (PEW) treatment on dextran sulfate sodium (DSS)-induced colitis in mice and the underlying mechanisms. The results showed that treatment with PEW in mice with DSS-induced colitis ...
DOI:
10.1016/j.fshw.2022.07.021

3. Anti-inflammatory and immunostimulant effect of different timing-related administration of dietary polyphenols on intestinal inflammation in zebrafish, Danio rerio

Author:
Roberta Imperatore; Graziella Orso; Serena Facchiano; Pierpaolo Scarano; Seyed Hossein Hoseinifar; Ghasem Ashouri; Carmine Guarino; Marina Paolucci
Source:
Aquaculture 2023 v.563 pp. 738878
ISSN:
0044-8486
Subject:
mitogen-activated protein kinase,   etc   ; Castanea sativa; Danio rerio; Verbascum; adults; antioxidant activity; antioxidants; aquaculture; assets; catalase; diet; feed additives; flavonoids; gene expression; immunostimulants; inflammation; interleukin-10; intestines; models; phosphorylation; polyphenols; prostaglandin synthase; superoxide dismutase; transcription factor NF-kappa B; tumor necrosis factors;     Show all 25 Subjects
Abstract:
... A short-term study was performed to assess the effects of diets supplemented with polyphenols (CSVP), extracted from the chestnut (Castanea sativa) shell, agri-food waste rich in tannins, and mullein (Verbascum macrurum), a perennial spontaneous plant rich in flavonoids, on a zebrafish (Danio rerio) model of k-carrageenan-induced intestinal inflammation. Morphological asset of intestine, immunoden ...
DOI:
10.1016/j.aquaculture.2022.738878

4. Genome-wide identification and expression profiling of thes MAPK, MAPKK, and MAPKKK gene families in Ophiocordyceps sinensis

Author:
Pan Yue; Han Zhang; Xinxin Tong; Ting Peng; Pan Tang; TingHui Gao; Jinlin Guo
Source:
Gene 2022 v.807 pp. 145930
ISSN:
0378-1119
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase; mitogen-activated protein kinase kinase kinase,   etc   ; Ophiocordyceps sinensis; eukaryotic cells; genes; phylogeny; quantitative polymerase chain reaction; signal transduction;     Show all 9 Subjects
Abstract:
... Mitogen-activated protein kinase (MAPK) cascades have a universal cell signaling mechanism in eukaryotes. A typical MAPK signal transduction module comprises three kinds of sequentially phosphorylated protein kinases: MAPK, Mitogen-activated protein kinase kinase (MAPKK), and Mitogen-activated protein kinase kinase kinase (MAPKKK). However, little is known regarding the genes involved in MAPK casc ...
DOI:
10.1016/j.gene.2021.145930

5. Identification and characterization of mkk genes and their expression profiles in rainbow trout (Oncorhynchus mykiss) symptomatically or asymptomatically infected with Vibrio anguillarum

Author:
Xiao-Dong Yang; Zhi-Shuai Hou; Meng-Qun Liu; Chu Zeng; Hong-Kui Zhao; Yuan-Ru Xin; Kai-Wen Xiang; Qian Yang; Hai-Shen Wen; Ji-Fang Li
Source:
Fish & shellfish immunology 2022 v.121 pp. 1-11
ISSN:
1050-4648
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase; mitogen-activated protein kinase kinase kinase,   etc   ; Oncorhynchus mykiss; Vibrio anguillarum; apoptosis; functional diversity; immunomodulation; inflammation; liver; shellfish; spleen; trout;     Show all 13 Subjects
Abstract:
... Mitogen-activated protein kinase kinases (MKKs) are intermediate kinases of mitogen-activated protein kinases (MAPKs) signaling pathways. MKKs are activated by mitogen-activated protein kinase kinase kinase (MKKK) and then the activated MKKs trigger the activation of downstream MAPKs. MAPK signaling pathways play an important role in regulating immune functions including apoptosis and inflammation ...
DOI:
10.1016/j.fsi.2021.12.049

6. Expression patterns and immunohistochemical analysis of ERK, HRAS and MEK1 proteins during ovarian prehierarchical follicular development in Zi geese (Anser cygnoides)

Author:
H. Lu; C.T. Sello; C. Liu; Y. Sui; C. Xu; Y. Sun; J. Liu; Y. Zhou; S. Li; W. Yang; P. Msuthwana; J. Hu
Source:
Indian journal of animal research 2022 v.56 no.7 pp. 790-795
ISSN:
0976-0555
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase,   etc   ; Anser cygnoides; animal research; follicular development; guanosinetriphosphatase; immunohistochemistry; proto-oncogenes; quantitative polymerase chain reaction;     Show all 9 Subjects
Abstract:
... The objective of this study was to investigate the spatiotemporal expression levels and protein localization of extracellular regulated MAP kinase (ERK), HRas proto-oncogene, GTPase (HRAS) and mitogen-activated protein kinase kinase 1 (MEK1) genes in ovarian prehierarchical follicles of geese. The prehierarchical follicles from healthy laying geese (n=6) at the age of 35 to 37 weeks were harvested ...
DOI:
10.18805/ijar.B-1069

7. LPA2 promotes neuronal differentiation and neurite formation in neocortical development

Author:
Mizuki Uenaka; Akiko Uyeda; Tsutomu Nakahara; Rieko Muramatsu
Source:
Biochemical and biophysical research communications 2022 v.598 pp. 89-94
ISSN:
0006-291X
Subject:
mitogen-activated protein kinase,   etc   ; agonists; lysophospholipids; neocortex; neurites; research;     Show all 6 Subjects
Abstract:
... Lysophosphatidic acid (LPA) is a bioactive lipid that activates the G protein-coupled receptors, LPA₁₋₆, which are associated with a wide number of cellular responses including proliferation, migration, differentiation, and survival. Although LPA₁₋₆ are expressed in the developing brain, their functions in brain development are not fully understood. In the present study, we analyzed the temporal e ...
DOI:
10.1016/j.bbrc.2022.01.109

8. Ca2+/Calmodulin Activates an MAP Kinase Through the Inhibition of a Protein Phosphatase (DsPTP1) in Arabidopsis

Author:
Kyung Eun Kim; Nhan Thi Nguyen; Sun Ho Kim; Sunghwa Bahk; Mi Sun Cheong; Hyeong Cheol Park; Kyun Oh Lee; Jong Chan Hong; Woo Sik Chung
Source:
Journal of plant biology 2022 v.65 no.1 pp. 65-74
ISSN:
1226-9239
Subject:
mitogen-activated protein kinase,   etc   ; Arabidopsis; calcium; dephosphorylation; plant biology;     Show all 5 Subjects
Abstract:
... Mitogen-activated protein kinases (MPKs) play roles as critical signal components in the environmental stress responses and developmental processes in plants. Calcium ion (Ca²⁺) is one of the most essential ubiquitous intracellular second messengers involved in many signal transduction pathways in plants. It was previously known that MPKs are activated by the increasing Ca²⁺ concentration. However ...
DOI:
10.1007/s12374-021-09338-x

9. SARM1 can be a potential therapeutic target for spinal cord injury

Author:
Qicheng Lu; Benson O. A. Botchway; Yong Zhang; Tian Jin; Xuehong Liu
Source:
Cellular and molecular life sciences 2022 v.79 no.3 pp. 161
ISSN:
1420-682X
Subject:
mitogen-activated protein kinase,   etc   ; animal injuries; nicotinamide; spinal cord; therapeutics;     Show all 5 Subjects
Abstract:
... Injury to the spinal cord is devastating. Studies have implicated Wallerian degeneration as the main cause of axonal destruction in the wake of spinal cord injury. Therefore, the suppression of Wallerian degeneration could be beneficial for spinal cord injury treatment. Sterile alpha and armadillo motif-containing protein 1 (SARM1) is a key modulator of Wallerian degeneration, and its impediment c ...
DOI:
10.1007/s00018-022-04195-4

10. 1-O-Alkylglycerol Ethers from the Marine Sponge Guitarra abbotti and Their Cytotoxic Activity

Author:
Sergey A. Dyshlovoy; Sergey N. Fedorov; Vasily I. Svetashev; Tatiana N. Makarieva; Anatoliy I. Kalinovsky; Olga P. Moiseenko; Vladimir B. Krasokhin; Larisa K. Shubina; Alla G. Guzii; Gunhild von Amsberg; Valentin A. Stonik
Source:
Marine drugs 2022 v.20 no.7 pp. -
ISSN:
1660-3397
Subject:
mitogen-activated protein kinase,   etc   ; Porifera; cytotoxicity; ethanol; fractionation; humans; lipids;     Show all 7 Subjects
Abstract:
... The cytotoxicity-bioassay-guided fractionation of the ethanol extract from the marine sponge Guitarra abbotti, whose 1-O-alkyl-sn-glycerol ethers (AGEs) have not been investigated so far, led to the isolation of a complex lipid fraction containing, along with previously known compounds, six new lipids of the AGE type. The composition of the AGE fraction as well as the structures of 6 new and 22 pr ...
DOI:
10.3390/md20070409

11. Structural characterization and expression analysis of novel MAPK1 transcript variants with the development of a multiplexed targeted nanopore sequencing approach

Author:
Konstantina Athanasopoulou; Panagiotis G. Adamopoulos; Andreas Scorilas
Source:
international journal of biochemistry & cell biology 2022 v.150 pp. 106272
ISSN:
1357-2725
Subject:
mitogen-activated protein kinase,   etc   ; alternative splicing; humans; nanopores; transcription (genetics);     Show all 5 Subjects
Abstract:
... Mitogen-activated protein kinases (MAPKs) represent a protein family firmly involved in many signaling cascades, regulating a vast spectrum of stimulated cellular processes. Studies have shown that alternatively spliced isoforms of MAPKs play a crucial role in determining the desired cell fate in response to specific stimulations. Although the implication of most MAPKs transcript variants in the M ...
DOI:
10.1016/j.biocel.2022.106272

12. GmMKK4‐activated GmMPK6 stimulates GmERF113 to trigger resistance to Phytophthora sojae in soybean

Author:
Hong Gao; Liangyu Jiang; Banghan Du; Bin Ning; Xiaodong Ding; Chuanzhong Zhang; Bo Song; Shanshan Liu; Ming Zhao; Yuxin Zhao; Tianyu Rong; Dongxue Liu; Junjiang Wu; Pengfei Xu; Shuzhen Zhang
Source:
plant journal 2022 v.111 no.2 pp. 473-495
ISSN:
0960-7412
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase,   etc   ; Arabidopsis; Glycine max; Phytophthora sojae; cultivars; pathogens; phenotype; phosphorylation; plant disease resistance; soybeans; stem rot; transcription (genetics); transcription factors;     Show all 14 Subjects
Abstract:
... Phytophthora root and stem rot is a worldwide soybean (Glycine max) disease caused by the soil‐borne pathogen Phytophthora sojae. This disease is devastating to soybean production, so improvement of resistance to P. sojae is a major target in soybean breeding. Mitogen‐activated protein kinase (MAPK) cascades are important signaling modules that convert environmental stimuli into cellular responses ...
DOI:
10.1111/tpj.15809

13. Genome-wide analysis of the hard clam mitogen-activated protein kinase kinase gene family and their transcriptional profiles under abiotic stress

Author:
Zhi Hu; Hao Song; Jie Feng; Cong Zhou; Mei-Jie Yang; Pu Shi; Zheng-Lin Yu; Yong-Ren Li; Yong-Jun Guo; Hai-Zhou Li; Su-Yao Wang; Jiang-Han Xue; Tao Zhang
Source:
Marine environmental research 2022 v.176 pp. 105606
ISSN:
0141-1136
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase,   etc   ; Mercenaria mercenaria; air; amino acids; clams; genes; genome-wide association study; heat; hemocytes; hypoxia; phylogeny; research; salt stress; transcription (genetics);     Show all 15 Subjects
Abstract:
... Mitogen-activated protein kinase kinase (MAPKK) was the hub component of the Mitogen-activated protein kinase (MAPK) signaling pathway and played an important role in the cellular response to environmental stress. In this study, we identified five MmMAPKK genes in hard clam Mercenaria mercenaria and found that all MmMAPKK genes contain a conserved protein kinase domain. The MmMAPKK genes derived f ...
DOI:
10.1016/j.marenvres.2022.105606

14. Expression changes of c-Fos and D1R/p-ERK1/2 signal pathways in nucleus accumbens of rats after ketamine abuse

Author:
Hua-chun Miao; Min Liu; Feng Wu; Huai-bin Li
Source:
Biochemical and biophysical research communications 2022 v.629 pp. 183-188
ISSN:
0006-291X
Subject:
mitogen-activated protein kinase kinase,   etc   ; antagonists; anxiety; dopamine; immunohistochemistry; ketamine; phosphorylation; research;     Show all 8 Subjects
Abstract:
... Ketamine is a commonly used dissociative anesthetic in clinical applications. However, the abuse potential has posted limits to its use and the mechanism remains to be studied. We aimed to investigate the changes of dopamine D1 receptors (D1R), phosphorylation of extracellular-regulated protein kinase 1/2 (p-ERK1/2), and c-Fos expression in the nucleus accumbens (NAc) of ketamine abuse rats. Ketam ...
DOI:
10.1016/j.bbrc.2022.08.091

15. Proliferation of bovine myoblast by LncPRRX1 via regulation of the miR-137/CDC42 axis

Author:
Wenzhen Zhang; Bing Sun; Yanqing Zhao; Sayed Haidar Abbas Raza; Yishu Li; Jianfang Wang; Xinhao Ma; Hailah M. Almohaimeed; Sameerah Shaheen; Faisal Al-Sarraj; Raed Albiheyri; Chugang Mei; Linsen Zan
Source:
International journal of biological macromolecules 2022 v.220 pp. 33-42
ISSN:
0141-8130
Subject:
mitogen-activated protein kinase,   etc   ; cattle; cell division; cell proliferation; genes; muscle tissues; myoblasts;     Show all 7 Subjects
Abstract:
... Noncoding RNAs, such as long noncoding RNAs (lncRNAs), are abundant in livestock. Many lncRNAs that affect the growth rate of livestock have been identified in muscles. However, some of their physiological functions and regulatory mechanisms remain unclear. In this study, we identified a new lncRNA (lncPRRX1) and investigated its effect on the proliferation of bovine myoblasts. LncPRRX1 was highly ...
DOI:
10.1016/j.ijbiomac.2022.08.018

16. Mitogen‐activated protein kinase cascades in plant signaling

Author:
Mengmeng Zhang; Shuqun Zhang
Source:
Journal of integrative plant biology 2022 v.64 no.2 pp. 301-341
ISSN:
1672-9072
Subject:
mitogen-activated protein kinase,   etc   ; genes; growth and development; immunity; ligands; peptides; plant biology;     Show all 7 Subjects
Abstract:
... Mitogen‐activated protein kinase (MAPK) cascades are key signaling modules downstream of receptors/sensors that perceive either endogenously produced stimuli such as peptide ligands and damage‐associated molecular patterns (DAMPs) or exogenously originated stimuli such as pathogen/microbe‐associated molecular patterns (P/MAMPs), pathogen‐derived effectors, and environmental factors. In this review ...
DOI:
10.1111/jipb.13215

17. Genome-wide identification of MAPK family genes and their response to abiotic stresses in tea plant (Camellia sinensis)

Author:
Xinhao Liu; Min Zhao; Caihua Gu; Haodong Jiang; Junyan Sun; Jie Li
Source:
Open life sciences 2022 v.17 no.1 pp. 1064-1074
ISSN:
2391-5412
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase kinase,   etc   ; Arabidopsis; Camellia sinensis; abiotic stress; cold; drought; genes; genome-wide association study; genomics; heat; phylogeny; reverse transcriptase polymerase chain reaction; signal transduction; tea;     Show all 15 Subjects
Abstract:
... Mitogen-activated protein kinase (MAPK) cascades are conserved and universal signal transduction modules that play important roles in regulating stress responses in plants. Although MAP3K, MP2K, and MPK family in tea plant (Camellia sinensis) have been investigated, little is known about MPK family genes responding to various abiotic stresses in tea plant. In this study, we performed a comprehensi ...
DOI:
10.1515/biol-2022-0466

18. Exploration of binding mechanism of triclosan towards cancer markers using molecular docking and molecular dynamics

Author:
Prashant Bhardwaj; G.P. Biswas; Nibedita Mahata; Susanta Ghanta; Biswanath Bhunia
Source:
Chemosphere 2022 v.293 pp. 133550
ISSN:
0045-6535
Subject:
mitogen-activated protein kinase,   etc   ; B-cell lymphoma; actin; apoptosis; energy; humans; molecular dynamics; triclosan;     Show all 8 Subjects
Abstract:
... The molecule 5-chloro-2-(2,4-dichlorophenoxy) phenol is well-known as Triclosan (TCS), which is also a potential endocrine disrupting synthetic chemical. TCS exposure has been connected to the control of the human enoyl-acyl carrier protein-reductase (hER), which has been linked to a range of life threatening diseases. However, other than hER, the new protein targets for TCS that are responsible f ...
DOI:
10.1016/j.chemosphere.2022.133550

19. Polysaccharides from Agrocybe cylindracea residue alleviate type 2-diabetes-induced liver and colon injuries by p38 MAPK signaling pathway

Author:
Wenxue Sun; Yaohan Zhang; Le Jia
Source:
Food bioscience 2022 v.47 pp. 101690
ISSN:
2212-4292
Subject:
mitogen-activated protein kinase,   etc   ; Agrocybe; blood glucose; colon; inflammation; lipids; liver; oxidative stress; polysaccharides;     Show all 9 Subjects
Abstract:
... In this experiment, we investigated the possible mechanism of polysaccharides from Agrocybe cylindracea residue (PACR) on ameliorating the type-2-diabetes-induced liver and colon injuries. Animal experiments have proved that PACR could reduce the oxidative damage and inflammatory response. Meanwhile, the PACR could restore lipid levels, decrease the level of liver and colon lesions in injured mice ...
DOI:
10.1016/j.fbio.2022.101690

20. The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells

Author:
Elliott M. Thompson; Vruti Patel; Vinothini Rajeeve; Pedro R Cutillas; Andrew W. Stoker
Source:
FEBS Open Bio 2022 v.12 no.7 pp. 1388-1405
ISSN:
2211-5463
Subject:
mitogen-activated protein kinase,   etc   ; CRISPR-Cas systems; cytotoxicity; phosphorylation; risk; sympathetic nervous system; therapeutics;     Show all 7 Subjects
Abstract:
... Neuroblastoma (NB) is a heterogeneous cancer of the sympathetic nervous system, which accounts for 7–10% of paediatric malignancies worldwide. Due to the lack of targetable molecular aberrations in NB, most treatment options remain relatively nonspecific. Here, we investigated the therapeutic potential of BCI, an inhibitor of DUSP1 and DUSP6, in cultured NB cells. BCI was cytotoxic in a range of N ...
DOI:
10.1002/2211-5463.13418