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... Environmental exposure to crystalline silica particles can lead to silicosis, which is one of the most serious pulmonary interstitial fibrosis around the world. Unfortunately, the exact mechanism on silicosis is unclear, and the effective treatments are lacking to date. In this study, we aim to explore the molecular mechanism by which interleukin-11 (IL-11) affects silica particles-induced lung in ...
... Traditional Chinese preserved egg products have exhibited some anti-inflammatory effects, but their mechanisms of action remain unknown. This study aimed to investigate the anti-inflammatory effects of preserved egg white (PEW) treatment on dextran sulfate sodium (DSS)-induced colitis in mice and the underlying mechanisms. The results showed that treatment with PEW in mice with DSS-induced colitis ...
... A short-term study was performed to assess the effects of diets supplemented with polyphenols (CSVP), extracted from the chestnut (Castanea sativa) shell, agri-food waste rich in tannins, and mullein (Verbascum macrurum), a perennial spontaneous plant rich in flavonoids, on a zebrafish (Danio rerio) model of k-carrageenan-induced intestinal inflammation. Morphological asset of intestine, immunoden ...
mitogen-activatedproteinkinase; mitogen-activatedproteinkinase kinase; mitogen-activatedproteinkinase kinase kinase, etc ; Ophiocordyceps sinensis; eukaryotic cells; genes; phylogeny; quantitative polymerase chain reaction; signal transduction; Show all 9 Subjects
Abstract:
... Mitogen-activated protein kinase (MAPK) cascades have a universal cell signaling mechanism in eukaryotes. A typical MAPK signal transduction module comprises three kinds of sequentially phosphorylated protein kinases: MAPK, Mitogen-activated protein kinase kinase (MAPKK), and Mitogen-activated protein kinase kinase kinase (MAPKKK). However, little is known regarding the genes involved in MAPK casc ...
... Mitogen-activated protein kinase kinases (MKKs) are intermediate kinases of mitogen-activated protein kinases (MAPKs) signaling pathways. MKKs are activated by mitogen-activated protein kinase kinase kinase (MKKK) and then the activated MKKs trigger the activation of downstream MAPKs. MAPK signaling pathways play an important role in regulating immune functions including apoptosis and inflammation ...
... The objective of this study was to investigate the spatiotemporal expression levels and protein localization of extracellular regulated MAP kinase (ERK), HRas proto-oncogene, GTPase (HRAS) and mitogen-activated protein kinase kinase 1 (MEK1) genes in ovarian prehierarchical follicles of geese. The prehierarchical follicles from healthy laying geese (n=6) at the age of 35 to 37 weeks were harvested ...
mitogen-activatedproteinkinase, etc ; agonists; lysophospholipids; neocortex; neurites; research; Show all 6 Subjects
Abstract:
... Lysophosphatidic acid (LPA) is a bioactive lipid that activates the G protein-coupled receptors, LPA₁₋₆, which are associated with a wide number of cellular responses including proliferation, migration, differentiation, and survival. Although LPA₁₋₆ are expressed in the developing brain, their functions in brain development are not fully understood. In the present study, we analyzed the temporal e ...
mitogen-activatedproteinkinase, etc ; Arabidopsis; calcium; dephosphorylation; plant biology; Show all 5 Subjects
Abstract:
... Mitogen-activated protein kinases (MPKs) play roles as critical signal components in the environmental stress responses and developmental processes in plants. Calcium ion (Ca²⁺) is one of the most essential ubiquitous intracellular second messengers involved in many signal transduction pathways in plants. It was previously known that MPKs are activated by the increasing Ca²⁺ concentration. However ...
mitogen-activatedproteinkinase, etc ; animal injuries; nicotinamide; spinal cord; therapeutics; Show all 5 Subjects
Abstract:
... Injury to the spinal cord is devastating. Studies have implicated Wallerian degeneration as the main cause of axonal destruction in the wake of spinal cord injury. Therefore, the suppression of Wallerian degeneration could be beneficial for spinal cord injury treatment. Sterile alpha and armadillo motif-containing protein 1 (SARM1) is a key modulator of Wallerian degeneration, and its impediment c ...
Sergey A. Dyshlovoy; Sergey N. Fedorov; Vasily I. Svetashev; Tatiana N. Makarieva; Anatoliy I. Kalinovsky; Olga P. Moiseenko; Vladimir B. Krasokhin; Larisa K. Shubina; Alla G. Guzii; Gunhild von Amsberg; Valentin A. Stonik
mitogen-activatedproteinkinase, etc ; Porifera; cytotoxicity; ethanol; fractionation; humans; lipids; Show all 7 Subjects
Abstract:
... The cytotoxicity-bioassay-guided fractionation of the ethanol extract from the marine sponge Guitarra abbotti, whose 1-O-alkyl-sn-glycerol ethers (AGEs) have not been investigated so far, led to the isolation of a complex lipid fraction containing, along with previously known compounds, six new lipids of the AGE type. The composition of the AGE fraction as well as the structures of 6 new and 22 pr ...
mitogen-activatedproteinkinase, etc ; alternative splicing; humans; nanopores; transcription (genetics); Show all 5 Subjects
Abstract:
... Mitogen-activated protein kinases (MAPKs) represent a protein family firmly involved in many signaling cascades, regulating a vast spectrum of stimulated cellular processes. Studies have shown that alternatively spliced isoforms of MAPKs play a crucial role in determining the desired cell fate in response to specific stimulations. Although the implication of most MAPKs transcript variants in the M ...
... Phytophthora root and stem rot is a worldwide soybean (Glycine max) disease caused by the soil‐borne pathogen Phytophthora sojae. This disease is devastating to soybean production, so improvement of resistance to P. sojae is a major target in soybean breeding. Mitogen‐activated protein kinase (MAPK) cascades are important signaling modules that convert environmental stimuli into cellular responses ...
mitogen-activatedproteinkinase; mitogen-activatedproteinkinase kinase, etc ; Mercenaria mercenaria; air; amino acids; clams; genes; genome-wide association study; heat; hemocytes; hypoxia; phylogeny; research; salt stress; transcription (genetics); Show all 15 Subjects
Abstract:
... Mitogen-activated protein kinase kinase (MAPKK) was the hub component of the Mitogen-activated protein kinase (MAPK) signaling pathway and played an important role in the cellular response to environmental stress. In this study, we identified five MmMAPKK genes in hard clam Mercenaria mercenaria and found that all MmMAPKK genes contain a conserved protein kinase domain. The MmMAPKK genes derived f ...
mitogen-activatedproteinkinase kinase, etc ; antagonists; anxiety; dopamine; immunohistochemistry; ketamine; phosphorylation; research; Show all 8 Subjects
Abstract:
... Ketamine is a commonly used dissociative anesthetic in clinical applications. However, the abuse potential has posted limits to its use and the mechanism remains to be studied. We aimed to investigate the changes of dopamine D1 receptors (D1R), phosphorylation of extracellular-regulated protein kinase 1/2 (p-ERK1/2), and c-Fos expression in the nucleus accumbens (NAc) of ketamine abuse rats. Ketam ...
mitogen-activatedproteinkinase, etc ; cattle; cell division; cell proliferation; genes; muscle tissues; myoblasts; Show all 7 Subjects
Abstract:
... Noncoding RNAs, such as long noncoding RNAs (lncRNAs), are abundant in livestock. Many lncRNAs that affect the growth rate of livestock have been identified in muscles. However, some of their physiological functions and regulatory mechanisms remain unclear. In this study, we identified a new lncRNA (lncPRRX1) and investigated its effect on the proliferation of bovine myoblasts. LncPRRX1 was highly ...
mitogen-activatedproteinkinase, etc ; genes; growth and development; immunity; ligands; peptides; plant biology; Show all 7 Subjects
Abstract:
... Mitogen‐activated protein kinase (MAPK) cascades are key signaling modules downstream of receptors/sensors that perceive either endogenously produced stimuli such as peptide ligands and damage‐associated molecular patterns (DAMPs) or exogenously originated stimuli such as pathogen/microbe‐associated molecular patterns (P/MAMPs), pathogen‐derived effectors, and environmental factors. In this review ...
mitogen-activatedproteinkinase; mitogen-activatedproteinkinase kinase kinase, etc ; Arabidopsis; Camellia sinensis; abiotic stress; cold; drought; genes; genome-wide association study; genomics; heat; phylogeny; reverse transcriptase polymerase chain reaction; signal transduction; tea; Show all 15 Subjects
Abstract:
... Mitogen-activated protein kinase (MAPK) cascades are conserved and universal signal transduction modules that play important roles in regulating stress responses in plants. Although MAP3K, MP2K, and MPK family in tea plant (Camellia sinensis) have been investigated, little is known about MPK family genes responding to various abiotic stresses in tea plant. In this study, we performed a comprehensi ...
mitogen-activatedproteinkinase, etc ; B-cell lymphoma; actin; apoptosis; energy; humans; molecular dynamics; triclosan; Show all 8 Subjects
Abstract:
... The molecule 5-chloro-2-(2,4-dichlorophenoxy) phenol is well-known as Triclosan (TCS), which is also a potential endocrine disrupting synthetic chemical. TCS exposure has been connected to the control of the human enoyl-acyl carrier protein-reductase (hER), which has been linked to a range of life threatening diseases. However, other than hER, the new protein targets for TCS that are responsible f ...
mitogen-activatedproteinkinase, etc ; Agrocybe; blood glucose; colon; inflammation; lipids; liver; oxidative stress; polysaccharides; Show all 9 Subjects
Abstract:
... In this experiment, we investigated the possible mechanism of polysaccharides from Agrocybe cylindracea residue (PACR) on ameliorating the type-2-diabetes-induced liver and colon injuries. Animal experiments have proved that PACR could reduce the oxidative damage and inflammatory response. Meanwhile, the PACR could restore lipid levels, decrease the level of liver and colon lesions in injured mice ...
mitogen-activatedproteinkinase, etc ; CRISPR-Cas systems; cytotoxicity; phosphorylation; risk; sympathetic nervous system; therapeutics; Show all 7 Subjects
Abstract:
... Neuroblastoma (NB) is a heterogeneous cancer of the sympathetic nervous system, which accounts for 7–10% of paediatric malignancies worldwide. Due to the lack of targetable molecular aberrations in NB, most treatment options remain relatively nonspecific. Here, we investigated the therapeutic potential of BCI, an inhibitor of DUSP1 and DUSP6, in cultured NB cells. BCI was cytotoxic in a range of N ...