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1. Protein kinases as targets for developing anticancer agents from marine organisms

Author:
Qiao, Gan; Bi, Kangping; Liu, Junhong; Cao, Shousong; Liu, Minghua; Pešić, Milica; Lin, Xiukun
Source:
Biochimica et biophysica acta 2021 v.1865 no.1 pp. 129759
ISSN:
0304-4165
Subject:
mitogen-activated protein kinase,   etc   ; ; biodiversity; humans;     Show all 4 Subjects
Abstract:
... Protein kinases play a fundamental role in the intracellular transduction because of their ability to phosphorylate plethora of proteins. Over the past three decades, numerous protein kinase inhibitors have been identified and are being used clinically successfully. The biodiversity of marine organisms provides a rich source for the discovery and development of novel anticancer agents in the treat ...
DOI:
10.1016/j.bbagen.2020.129759

2. Protein kinases in plant responses to drought, salt, and cold stress

Author:
Chen, Xuexue; Ding, Yanglin; Yang, Yongqing; Song, Chunpeng; Wang, Baoshan; Yang, Shuhua; Guo, Yan; Gong, Zhizhong
Source:
Journal of integrative plant biology 2021 v.63 no.1 pp. 53-78
ISSN:
1672-9072
Subject:
mitogen-activated protein kinase,   etc   ; cold stress; drought; signal transduction; sucrose;     Show all 5 Subjects
Abstract:
... Protein kinases are major players in various signal transduction pathways. Understanding the molecular mechanisms behind plant responses to biotic and abiotic stresses has become critical for developing and breeding climate‐resilient crops. In this review, we summarize recent progress on understanding plant drought, salt, and cold stress responses, with a focus on signal perception and transductio ...
DOI:
10.1111/jipb.13061

3. A Putative MAPK Kinase Kinase Gene Ssos4 is Involved in Mycelial Growth, Virulence, Osmotic Adaptation, and Sensitivity to Fludioxonil and is Essential for SsHog1 Phosphorylation in Sclerotinia sclerotiorum

Author:
Li, Tao; Xiu, Qian; Wang, Jianxin; Duan, Yabing; Zhou, Mingguo
Source:
Phytopathology 2021 v.111 no.3 pp. 521-530
ISSN:
0031-949X
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase,   etc   ; ; Sclerotinia sclerotiorum; cell walls; fludioxonil; genes; glycerol; hyphae; mutants; mycelium; osmolarity; phosphorylation; plant pathology; sclerotia; virulence;     Show all 16 Subjects
Abstract:
... The high osmolarity glycerol (HOG) pathway, comprising a two-component system and the Hog1 mitogen-activated protein kinase (MAPK) cascade, plays a pivotal role in eukaryotic organisms. Previous studies suggested that the biological functions of some key genes in the HOG pathway varied in filamentous fungi. In this study, we characterized a putative MAPK kinase kinase gene, Ssos4, in Sclerotinia s ...
DOI:
10.1094/PHYTO-07-20-0292-R

4. Arabidopsis E3 ligase KEG associates with and ubiquitinates MKK4 and MKK5 to regulate plant immunity

Author:
Gao, Chenyang; Sun, Pengwei; Wang, Wei; Tang, Dingzhong
Source:
Journal of integrative plant biology 2021 v.63 no.2 pp. 327-339
ISSN:
1672-9072
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase,   etc   ; ; Arabidopsis thaliana; Golovinomyces; homeostasis; mutants; pathogens; phosphorylation; plant biology; powdery mildew; ubiquitin-protein ligase; ubiquitination;     Show all 13 Subjects
Abstract:
... Mitogen‐activated protein kinase (MAPK) cascades are highly conserved signaling modules that regulate plant immune responses. The Arabidopsis thaliana Raf‐like MAPK kinase kinase ENHANCED DISEASE RESISTANCE1 (EDR1) is a key negative regulator of plant immunity that affects the protein levels of MKK4 and MKK5, two important MAPK cascade members, but the underlying mechanism is poorly understood. He ...
DOI:
10.1111/jipb.13007

5. Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach

Author:
Genolet, Oriana; Monaco, Anna A.; Dunkel, Ilona; Boettcher, Michael; Schulz, Edda G.
Source:
Genome biology 2021 v.22 no.1 pp. 110
ISSN:
1474-760X
Subject:
mitogen-activated protein kinase,   etc   ; early development; females; gene expression; mice; phenotype;     Show all 6 Subjects
Abstract:
... BACKGROUND: X-chromosomal genes contribute to sex differences, in particular during early development, when both X chromosomes are active in females. Double X-dosage shifts female pluripotent cells towards the naive stem cell state by increasing pluripotency factor expression, inhibiting the differentiation-promoting MAP kinase (MAPK) signaling pathway, and delaying differentiation. RESULTS: To id ...
DOI:
10.1186/s13059-021-02321-2

6. Two VQ Proteins are Substrates of the OsMPKK6-OsMPK4 Cascade in Rice Defense Against Bacterial Blight

Author:
Li, Na; Yang, Zeyu; Li, Juan; Xie, Wenya; Qin, Xiaofeng; Kang, Yuanrong; Zhang, Qinglu; Li, Xianghua; Xiao, Jinghua; Ma, Haigang; Wang, Shiping
Source:
Rice 2021 v.14 no.1 pp. 39
ISSN:
1939-8425
Subject:
mitogen-activated protein kinase,   etc   ; Xanthomonas oryzae pv. oryzae; blight; disease resistance; immunity; rice; signal transduction;     Show all 7 Subjects
Abstract:
... BACKGROUND: The plant-specific valine-glutamine (VQ) protein family with the conserved motif FxxxVQxLTG reportedly functions with the mitogen-activated protein kinase (MAPK) in plant immunity. However, the roles of VQ proteins in MAPK-mediated resistance to disease in rice remain largely unknown. RESULTS: In this study, two rice VQ proteins OsVQ14 and OsVQ32 were newly identified to function as th ...
DOI:
10.1186/s12284-021-00483-y

7. Xanthoangelol modulates Caspase-1-dependent pyroptotic death among hepatocellular carcinoma cells with high expression of GSDMD

Author:
Pang, Xuening; Gao, Xiang; Liu, Feng; Jiang, Yuhuan; Wang, Mingji; Li, Qun; Li, Zichao
Source:
Journal of functional foods 2021 v.84 pp. 104577
ISSN:
1756-4646
Subject:
mitogen-activated protein kinase,   etc   ; Angelica keiskei; caspase-1; cell viability; chalcone; hepatoma; pyroptosis; therapeutics;     Show all 8 Subjects
Abstract:
... Xanthoangelol (XAG), a major chalcone presents in Angelica keiskei, has been employed in research to develop functional supplements or drugs due to its various pharmacological activities. Here, we investigated the underlying mechanism of XAG-induced cell death in hepatocellular carcinoma (HCC). We found that XAG inhibited the cell viability of either HepG2 or HuH7cells, and induced pyroptotic deat ...
DOI:
10.1016/j.jff.2021.104577

8. Nitric oxide mediates disruption of human placental trophoblast invasion induced by perfluorobutane sulfonate

Author:
Du, Yatao; Cai, Zhenzhen; Zhang, Huihui; Liang, Wei; Wang, Hui; Man, Qiuhong; Wang, Weiye
Source:
Environmental pollution 2021 v.283 pp. 117137
ISSN:
0269-7491
Subject:
mitogen-activated protein kinase,   etc   ; gelatinase B; humans; nitric oxide; phosphorylation; pollutants; pollution; pregnancy; sulfonates; trophoblast;     Show all 10 Subjects
Abstract:
... Perfluorobutane sulfonate (PFBS), an emerging pollutant, is associated with disruption of placental functions and adverse birth outcomes. However, the precise mechanism of this disruption remains unclear. Extravillous trophoblasts make up the majority of cells in the placenta, and have invasive abilities, which plays a critical role in a successful pregnancy. It has been reported that inducible ni ...
DOI:
10.1016/j.envpol.2021.117137

9. Dual-specificity phosphatase 6 (DUSP6) mRNA and protein abundance is regulated by fibroblast growth factor 2 in sheep granulosa cells and inhibits c-Jun N-terminal kinase (MAPK8) phosphorylation

Author:
Relav, Lauriane; Estienne, Anthony; Price, Christopher A.
Source:
Molecular and cellular endocrinology 2021 v.531 pp. 111297
ISSN:
0303-7207
Subject:
mitogen-activated protein kinase,   etc   ; endocrinology; fibroblast growth factor 2; ligands; models; phosphorylation; sheep;     Show all 7 Subjects
Abstract:
... Growth factors regulate ovarian follicle development and they signal through intracellular pathways including mitogen-activated protein kinase (MAPK) phosphorylation, which is negatively regulated by a subfamily of 23 dual-specificity phosphatases (DUSP). Using sheep granulosa cells as a model, we detected mRNA encoding 16 DUSPs in vivo and in vitro. Stimulation of cells in vitro with FGF2 increas ...
DOI:
10.1016/j.mce.2021.111297

10. A human β-casein-derived peptide BCCY-1 modulates the innate immune response

Author:
Cai, Jinyang; Li, Xin; Wang, Xing; Jiang, Chengfei; Shen, Dan; Cui, Xianwei; Xie, Kaipeng; Ji, Chenbo; Cao, Yan
Source:
Food chemistry 2021 v.348 pp. 129111
ISSN:
0308-8146
Subject:
mitogen-activated protein kinase,   etc   ; breast milk; chemokines; food chemistry; humans; immunomodulation; immunomodulators; innate immunity; milk; monocytes;     Show all 10 Subjects
Abstract:
... In this study, we report a novel peptide corresponding to the sequence of human β-casein (named BCCY-1), which was identified in our previous peptidome analysis of human milk and has great immunomodulatory activity. The results revealed that peptide BCCY-1, but not the scrambled version, enhanced monocyte migration without obvious toxicities. This selective effect was mediated via increased produc ...
DOI:
10.1016/j.foodchem.2021.129111

11. The association between ERK inhibitor sensitivity and molecular characteristics in colorectal cancer

Author:
Tayama, Hodaka; Karasawa, Hideaki; Yamamura, Akihiro; Okamura, Yasunobu; Katsuoka, Fumiki; Suzuki, Hideyuki; Kajiwara, Taiki; Kobayashi, Minoru; Hatsuzawa, Yuuri; Shiihara, Masahiro; Bin, Li; Gazi, Md Yeashin; Sato, Mizuki; Kumada, Kazuki; Ito, Shigehiro; Shimada, Muneaki; Furukawa, Toru; Kamei, Takashi; Ohnuma, Shinobu; Unno, Michiaki
Source:
Biochemical and biophysical research communications 2021 v.560 pp. 59-65
ISSN:
0006-291X
Subject:
mitogen-activated protein kinase,   etc   ; ; colorectal neoplasms; drugs; genes; mutation; organoids; precision medicine; research;     Show all 9 Subjects
Abstract:
... The mitogen-activated protein kinase (MAPK) pathway plays an important role in the colorectal cancer (CRC) progression, being supposed to be activated by the gene mutations, such as BRAF or KRAS. Although the inhibitors of extracellular signal-regulated kinase (ERK) have demonstrated efficacy in the cells with the BRAF or KRAS mutations, a clinical response is not always associated with the molecu ...
DOI:
10.1016/j.bbrc.2021.04.130

12. Phosphoinositide signaling plays a key role in the regulation of cell wall reconstruction during the postharvest morphological development of Dictyophora indusiata

Author:
Geng, Fang; Wen, Xuefei; Xu, Yisha; Zhang, Miao; Zhou, Lin; Liu, Dayu; Li, Xiang; Wang, Jinqiu
Source:
Food chemistry 2021 v.346 pp. 128890
ISSN:
0308-8146
Subject:
mitogen-activated protein kinase,   etc   ; Dictyophora; bioinformatics; cell walls; food chemistry; metabolism; phosphoproteome; phosphorylation; starch; sucrose; synthesis;     Show all 11 Subjects
Abstract:
... The potential signaling mechanism of Dictyophora indusiata during postharvest morphological development was investigated through quantitative phosphoproteomic analyses. A total of 1566 phosphorylation sites changed significantly (872 upregulated and 694 downregulated) in the mature stage compared with those in the peach-shaped stage of D. indusiata. Bioinformatics analysis showed that the upregula ...
DOI:
10.1016/j.foodchem.2020.128890

13. Two Small Molecule Inhibitors Promote Reprogramming of Guangxi Bama Mini-Pig Mesenchymal Stem Cells Into Naive-Like State Induced Pluripotent Stem Cells

Author:
Chen, Feng; Shi, Deshun; Zou, Lingxiu; Yang, Xiaoling; Qiao, Shuye; Zhang, Ruimen; Yang, Sufang; Deng, Yanfei
Source:
Cellular reprogramming 2021 v.23 no.3 pp. 158-167
ISSN:
2152-4998
Subject:
mitogen-activated protein kinase,   etc   ; blastocyst; bone marrow; cytokines; miniature swine; models; signal transduction; swine; China;     Show all 9 Subjects
Abstract:
... Past researches have shown that pluripotency maintenance of naive and primed-state pluripotent stem cells (PSCs) depends on different signaling pathways, and naive-state PSCs possess the ability to produce chimeras when they are introduced into a blastocyst. Considering porcine is an attractive model for preclinical studies, many researches about pig induced pluripotent stem cells (piPSCs) have be ...
DOI:
10.1089/cell.2020.0094

14. A dual-specificity phosphatase, MAP kinase phosphatase 1, positively regulates blue light-mediated seedling development in Arabidopsis

Author:
Verma, Deepanjali; Bhagat, Prakash Kumar; Sinha, Alok Krishna
Source:
Planta 2021 v.253 no.6 pp. 131
ISSN:
0032-0935
Subject:
mitogen-activated protein kinase,   etc   ; Arabidopsis; blue light; hypocotyls; seedlings; threonine; tyrosine;     Show all 7 Subjects
Abstract:
... MAIN CONCLUSION: A dual-specificity phosphatase MKP1 negatively regulates the activity of MPK6 by dephosphorylating it and acts as a positive regulator of blue light (BL)-mediated photomorphogenic development in Arabidopsis. Reversible phosphorylation of proteins is one of the major post-translational modifications in nearly all signaling pathways in plants. MAP kinase phosphatases are very crucia ...
DOI:
10.1007/s00425-021-03649-6

15. MEKK3 activates IRF7 to trigger a potent type I interferon induction in response to TLR7/9 signaling

Author:
Cai, Miaomiao; Huang, Wenwu; Hu, Xiaodong; Chen, Ao; Zhou, Xiang
Source:
Molecular immunology 2021 v.134 pp. 183-191
ISSN:
0161-5890
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; DNA; interferon regulatory factor-7; interferons; ligands; pathogens; phosphorylation;     Show all 7 Subjects
Abstract:
... Interferon regulatory factor 7 (IRF7) is a crucial regulator of type I interferons (IFNs) against pathogen infections and plays a significant role in the endosomal Toll-like receptor signaling (namely, TLR7 and TLR9) in plasmacytoid dendritic cells (pDCs). In this study, we identify MEKK3, one of the MAP3K kinase, as a potent stimulator of IRF7 upon cellular activation of the TLR7/9 signaling path ...
DOI:
10.1016/j.molimm.2021.03.008

16. Molecular characterization, expression and function analysis of Epinephelus coioides MKK4 response to SGIV and Vibrio alginolyticus infection

Author:
Su, Yu-Ling; Jiang, Yu-Feng; Chen, He-Jia; Ye, Shi; Zhou, Wei-Hua; Liu, Hong-Ping; Dong, Jun-De; Wei, Jing-Guang; Qin, Qi-Wei; Sun, Hongyan
Source:
Developmental and comparative immunology 2021 v.119 pp. 104020
ISSN:
0145-305X
Subject:
mitogen-activated protein kinase,   etc   ; Epinephelus coioides; Singapore; Vibrio alginolyticus; grouper; immunology; inflammation; reporter genes; viruses;     Show all 9 Subjects
Abstract:
... Mitogen-activated protein kinase 4 (MKK4), a member of the MAP kinase family, play important roles in response to many environmental and cellular stresses in mammals. In this study, three MKK4 subtypes, EcMKK4-1, EcMKK4-2 and EcMKK4-3, were obtained from grouper Epinephelus coioides. The open reading frame (ORF) of EcMKK4s are obtained and the EcMKK4s proteins contain highly conserved domains: a S ...
DOI:
10.1016/j.dci.2021.104020

17. Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

Author:
Tulpule, Asmin; Guan, Juan; Neel, Dana S.; Allegakoen, Hannah R.; Lin, Yone Phar; Brown, David; Chou, Yu-Ting; Heslin, Ann; Chatterjee, Nilanjana; Perati, Shriya; Menon, Shruti; Nguyen, Tan A.; Debnath, Jayanta; Ramirez, Alejandro D.; Shi, Xiaoyu; Yang, Bin; Feng, Siyu; Makhija, Suraj; Huang, Bo; Bivona, Trever G.
Source:
Cell 2021 v.184 no.10 pp. 2649-2664.e18
ISSN:
0092-8674
Subject:
mitogen-activated protein kinase,   etc   ; guanosinetriphosphatase; lipids; mammals; oncogene proteins; receptor protein-tyrosine kinase;     Show all 6 Subjects
Abstract:
... Receptor tyrosine kinase (RTK)-mediated activation of downstream effector pathways such as the RAS GTPase/MAP kinase (MAPK) signaling cascade is thought to occur exclusively from lipid membrane compartments in mammalian cells. Here, we uncover a membraneless, protein granule-based subcellular structure that can organize RTK/RAS/MAPK signaling in cancer. Chimeric (fusion) oncoproteins involving cer ...
DOI:
10.1016/j.cell.2021.03.031

18. ERβ regulated ovarian kisspeptin plays an important role in oocyte maturation

Author:
Chakravarthi, V. Praveen; Ghosh, Subhra; Housami, Sami M.; Wang, Huizhen; Roby, Katherine F.; Wolfe, Michael W.; Kinsey, William H.; Rumi, M.A. Karim
Source:
Molecular and cellular endocrinology 2021 v.527 pp. 111208
ISSN:
0303-7207
Subject:
mitogen-activated protein kinase,   etc   ; ; calcium; estrogen receptors; gonadotropins; granulosa cells; kisspeptin; oocytes; rats;     Show all 9 Subjects
Abstract:
... Kisspeptin (KISS1) signaling in the hypothalamic-pituitary (H–P) axis plays an essential role in regulating gonadotropin secretion. KISS1 and KISS1 receptor (KISS1R) are also expressed in the ovary; however, the role of intraovarian KISS1 signaling remains unclear. Granulosa cell (GC)-specific expression of KISS1, and oocyte-specific expression of KISS1R indicate that GC-derived KISS1 may act on o ...
DOI:
10.1016/j.mce.2021.111208

19. Regulation of docosahexaenoic acid-induced apoptosis of confluent endothelial cells: Contributions of MAPKs and caspases

Author:
Du, Youjia; Taylor, Carla G.; Aukema, Harold M.; Zahradka, Peter
Source:
Biochimica et biophysica acta 2021 v.1866 no.5 pp. 158902
ISSN:
1388-1981
Subject:
mitogen-activated protein kinase,   etc   ; apoptosis; caspase-3; caspase-8; caspase-9; docosahexaenoic acid; homeostasis; humans; viability;     Show all 9 Subjects
Abstract:
... Endothelial cells, which help to maintain vascular homeostasis, can be functionally modulated by polyunsaturated fatty acids. Previously, we reported that docosahexaenoic acid (DHA) reduced the viability of confluent EA.hy926 endothelial cells with caspase-3 activation. This study therefore examined the molecular mechanism by which DHA affects the viability of confluent cells, with a focus on the ...
DOI:
10.1016/j.bbalip.2021.158902

20. ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth

Author:
Gilbert, Christopher J.; Longenecker, Jacob Z.; Accornero, Federica
Source:
Biology 2021 v.10 no.4
ISSN:
2079-7737
Subject:
mitogen-activated protein kinase,   etc   ; cardiomyocytes; cell viability; homeostasis; hypertrophy; signal transduction;     Show all 6 Subjects
Abstract:
... Integration of cellular responses to extracellular cues is essential for cell survival and adaptation to stress. Extracellular signal-regulated kinase (ERK) 1 and 2 serve an evolutionarily conserved role for intracellular signal transduction that proved critical for cardiomyocyte homeostasis and cardiac stress responses. Considering the importance of ERK1/2 in the heart, understanding how these ki ...
DOI:
10.3390/biology10040346