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1. ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains

Author:
Vind, Anna Constance; Snieckute, Goda; Blasius, Melanie; Tiedje, Christopher; Krogh, Nicolai; Bekker-Jensen, Dorte Breinholdt; Andersen, Kasper Langebjerg; Nordgaard, Cathrine; Tollenaere, Maxim Alexander Xavier; Lund, Anders Henrik; Olsen, Jesper Velgaard; Nielsen, Henrik; Bekker-Jensen, Simon
Source:
Molecular cell 2020 v.78 no.4 pp. 700-713.e7
ISSN:
1097-2765
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase kinase,   etc   ; Caenorhabditis elegans; longevity; phenotype; ribosomal RNA; ribosomes; stress response;     Show all 8 Subjects
Abstract:
... Impairment of ribosome function activates the MAPKKK ZAK, leading to activation of mitogen-activated protein (MAP) kinases p38 and JNK and inflammatory signaling. The mechanistic basis for activation of this ribotoxic stress response (RSR) remains completely obscure. We show that the long isoform of ZAK (ZAKα) directly associates with ribosomes by inserting its flexible C terminus into the ribosom ...
DOI:
10.1016/j.molcel.2020.03.021

2. An adaptor protein BmSte50 interacts with BmSte11 MAPKKK and is involved in host infection, conidiation, melanization, and sexual development in Bipolaris maydis

Author:
Sumita, Takuya; Izumitsu, Kosuke; Shigeyoshi, Sae; Gotoh, Shunsuke; Yoshida, Hiroki; Tsuji, Kenya; Yoshida, Hiroshi; Kitade, Yuki; Tanaka, Chihiro
Source:
Mycoscience 2020 v.61 no.2 pp. 85-94
ISSN:
1340-3540
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase; mitogen-activated protein kinase kinase kinase,   etc   ; Bipolaris maydis; Saccharomyces cerevisiae; appressoria; conidia; conidiation; genes; melanization; mutants; pathogenicity; phenotype; sexual development; signal transduction; spore germination; two hybrid system techniques; yeasts;     Show all 18 Subjects
Abstract:
... A mitogen-activated protein kinase (MAPK) signaling pathway regulates specialized cellular responses to external stimuli. In Bipolaris maydis, a Chk1 MAPK orthologous to Fus3/Kss1 MAPKs of Saccharomyces cerevisiae is known to regulate various developmental processes, including the formation of appressoria. However, upstream factors that regulate the Chk1 cascade have not been well clarified. In th ...
DOI:
10.1016/j.myc.2019.10.003

3. Early But Not Delayed Optogenetic RAF Activation Promotes Astrocytogenesis in Mouse Neural Progenitors

Author:
Su, Yixun; Huang, Xiaomin; Huang, Zhangsen; Huang, Taida; Li, Tao; Fan, Huaxun; Zhang, Kai; Yi, Chenju
Source:
Journal of molecular biology 2020 v.432 no.16 pp. 4358-4368
ISSN:
0022-2836
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase,   etc   ; astrocytes; cell differentiation; cell proliferation; enzyme activation; genes; mice; neural stem cells; neurites; neurogenesis; optogenetics; plasma membrane; signal transduction;     Show all 14 Subjects
Abstract:
... The RAS/RAF/MEK/ERK pathway promotes gliogenesis but the kinetic role of RAF1, a key RAF kinase, in the induction of astrocytogenesis remains to be elucidated. To address this challenge, we determine the temporal functional outcome of RAF1 during mouse neural progenitor cell differentiation using an optogenetic RAF1 system (OptoRAF1). OptoRAF1 allows for reversible activation of the RAF/MEK/ERK pa ...
DOI:
10.1016/j.jmb.2020.06.020

4. MAPKKK gene family in Dunaliella salina: identification, interaction network, and expression patterns under abiotic stress

Author:
Tang, Ziyi; Cao, Xiyue; Qiao, Jinnan; Huang, Guoyin; Lian, Weishao; Qiao, Dairong; Xu, Hui; Cao, Yi
Source:
Journal of applied phycology 2020 v.32 no.1 pp. 243-253
ISSN:
0921-8971
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase kinase,   etc   ; Dunaliella salina; abiotic stress; bioinformatics; biotic stress; cytokinesis; databases; genes; oxidative stress; phylogeny; plant growth; transcription (genetics); transcriptome;     Show all 14 Subjects
Abstract:
... Mitogen-activated protein kinase kinase kinase (MAPKKK) is a component of the MAPK cascade pathway that plays an essential role in plant growth, development, and response to biotic and abiotic stress in several plant species. However, the MAPKKK family genes from the green alga Dunaliella salina have not been thoroughly characterized to date. In this study, we performed transcriptome and bioinform ...
DOI:
10.1007/s10811-019-01939-x

5. Canine histiocytic sarcoma cell lines with SHP2 p.Glu76Gln or p.Glu76Ala mutations are sensitive to allosteric SHP2 inhibitor SHP099

Author:
Tani, Hiroyuki; Kurita, Sena; Miyamoto, Ryo; Ochiai, Kazuhiko; Tamura, Kyoichi; Bonkobara, Makoto
Source:
Veterinary and comparative oncology 2020 v.18 no.2 pp. 161-168
ISSN:
1476-5810
Subject:
mitogen-activated protein kinase,   etc   ; computer simulation; dogs; mutants; mutation; neoplasm cells; sarcoma;     Show all 7 Subjects
Abstract:
... Some canine cases of histiocytic sarcoma (HS) carry an activating mutation in the src homology two domain‐containing phosphatase 2 (SHP2) encoded by PTPN11. SHP099 is an allosteric inhibitor of SHP2 that stabilizes SHP2 in a folded, auto‐inhibited conformation. Here, we examined the expression and mutation status of SHP2 in five canine HS cell lines and evaluated the growth inhibitory properties o ...
DOI:
10.1111/vco.12524

6. Crosstalk between Saccharomycescerevisiae SAPKs Hog1 and Mpk1 is mediated by glycerol accumulation

Author:
Laz, Ekaterina V.; Lee, Jongmin; Levin, David E.
Source:
Fungal biology 2020 v.124 no.5 pp. 361-367
ISSN:
1878-6146
Subject:
mitogen-activated protein kinase,   etc   ; Saccharomyces cerevisiae; cell walls; glycerol; loss-of-function mutation; mutants; osmolarity;     Show all 7 Subjects
Abstract:
... Two stress-activated MAP kinase (SAPK) pathways in Saccharomyces cerevisiae respond to osmotic imbalances. The High Osmolarity Glycerol (HOG) pathway is activated in response to hyper-osmotic stress, whereas the Cell Wall Integrity (CWI) pathway is activated in response to hypo-osmotic stress. However, there is also evidence of complex interplay and crosstalk between the two pathways. For example, ...
DOI:
10.1016/j.funbio.2019.10.002
PubMed:
32389298
PubMed Central:
PMC7217976

7. Testosterone modulates structural synaptic plasticity of primary cultured hippocampal neurons through ERK - CREB signalling pathways

Author:
Guo, Guoxin; Kang, Lin; Geng, Dandan; Han, Shuo; Li, Sha; Du, Juan; Wang, Chang; Cui, Huixian
Source:
Molecular and cellular endocrinology 2020 v.503 pp. 110671
ISSN:
0303-7207
Subject:
mitogen-activated protein kinase,   etc   ; binding proteins; brain; messenger RNA; neurons; neuroplasticity; phosphorylation; signal transduction; testosterone;     Show all 9 Subjects
Abstract:
... Although hippocampus-derived androgens play an important role in hippocampal synaptic plasticity, studies at the cellular level have received relatively less attention. Furthermore, the underlying signalling pathways associated with synaptic plasticity remain unclear. Results of the present study demonstrated that testosterone treatment of primary cultured rat hippocampal neurons resulted in a rap ...
DOI:
10.1016/j.mce.2019.110671

8. Activation of autophagy and IL-10 production are regulated by Jun N-terminal kinase 1 and 2 and p38 mitogen activated protein kinase signaling pathways during Talaromyces marneffei infection within dendritic cells

Author:
Chen, Renqiong; Ji, Guangquan; Ren, Hong; Liu, Zhonglun; Feng, Shan; Zhang, Tingting; Xi, Liyan; Li, Xiaoming
Source:
Microbial pathogenesis 2020 v.139 pp. 103891
ISSN:
0882-4010
Subject:
mitogen-activated protein kinase,   etc   ; Talaromyces; autophagy; dendritic cells; humans; interleukin-10; interleukin-1beta; secretion; signal transduction;     Show all 9 Subjects
Abstract:
... Previous study have shown that Talaromyces marneffei (T. marneffei) induced activation of autophagy. Therefore, we explore signaling pathway that regulates activation of autophagy by intracellular signaling mechanisms during T. marneffei infection. Further, we examine c-Jun N-terminal kinase 1 and 2 (JNK1/2) and p38 signaling pathways that regulate IL-1β and IL-10 production and activation of auto ...
DOI:
10.1016/j.micpath.2019.103891

9. MAPK Signaling: Emerging Roles in Lateral Root Formation

Author:
He, Yunxia; Meng, Xiangzong
Source:
Trends in plant science 2020 v.25 no.2 pp. 126-129
ISSN:
1360-1385
Subject:
mitogen-activated protein kinase,   etc   ; Arabidopsis; auxins; lateral roots; morphogenesis; peptide hormones; signal transduction;     Show all 7 Subjects
Abstract:
... Lateral root (LR) formation is a multistep developmental process in which auxin and peptide hormones play essential roles. Recent studies in arabidopsis by Huang et al. and Zhu et al. have revealed that the mitogen-activated protein kinase (MAPK) cascade MKK4/MKK5–MPK3/MPK6 functions in both a noncanonical auxin signaling pathway and the IDA peptide signaling pathway to regulate LR morphogenesis a ...
DOI:
10.1016/j.tplants.2019.11.006

10. Single-domain antibodies for functional targeting of the signaling scaffold Shoc2

Author:
Jang, HyeIn; Wilson, Patricia G.; Sau, Mary; Chawla, Udeep; Rodgers, David W.; Galperin, Emilia
Source:
Molecular immunology 2020 v.118 pp. 110-116
ISSN:
0161-5890
Subject:
mitogen-activated protein kinase,   etc   ; antibodies; binding capacity; humans; moieties; multiprotein complexes; protein binding; scaffolding proteins;     Show all 8 Subjects
Abstract:
... The accurate transmission of signals by the canonical ERK1/2 kinase pathway critically relies on the proper assembly of an intricate multiprotein complex by the scaffold protein Shoc2. However, the details of the mechanism by which Shoc2 guides ERK1/2 signals are not clear, in part, due to the lack of research tools targeting specific protein binding moieties of Shoc2. We report generation and cha ...
DOI:
10.1016/j.molimm.2019.12.010
PubMed:
31869742
PubMed Central:
PMC6981032

11. Banana MaBZR1/2 associate with MaMPK14 to modulate cell wall modifying genes during fruit ripening

Author:
Shan, Wei; Guo, Yu-Fan; Wei, Wei; Chen, Jian-Ye; Lu, Wang-Jin; Yuan, De-Bao; Su, Xin-Guo; Kuang, Jian-Fei
Source:
Plant cell reports 2020 v.39 no.1 pp. 35-46
ISSN:
0721-7714
Subject:
mitogen-activated protein kinase,   etc   ; bananas; cell walls; fluorescence; genes; ripening; transcription (genetics); two hybrid system techniques;     Show all 8 Subjects
Abstract:
... KEY MESSAGE: Banana MaBZR1/2 interact with MaMPK14 to enhance the transcriptional inhibition of cell wall modifying genes including MaEXP2, MaPL2 and MaXET5. Fruit ripening and softening, the major attributes to perishability in fleshy fruits, are modulated by various plant hormones and gene expression. Banana MaBZR1/2, the central transcription factors of brassinosteroid (BR) signaling, mediate f ...
DOI:
10.1007/s00299-019-02471-5

12. Manganese modifies Neurotrophin-3 (NT3) and its tropomyosin receptor kinase C (TrkC) in the cortex: Implications for manganese-induced neurotoxicity

Author:
Yang, Yiping; Wei, Fu; Wang, Jian; Chen, Rui; Zhang, Jie; Li, Danni; Gan, Dong; Yang, Xiaobo; Zou, Yunfeng
Source:
Food and chemical toxicology 2020 v.135 pp. 110925
ISSN:
0278-6915
Subject:
mitogen-activated protein kinase,   etc   ; apoptosis; caspase-3; cortex; ligands; manganese; neurons; neurotoxicity; signal transduction; tropomyosins;     Show all 10 Subjects
Abstract:
... Manganese (Mn), an essential micronutrient, has the potential to induce apoptosis. The NT3/TrkC ligand/receptor pair known as part of the classic neurotrophic theory plays a critical role in neuronal survival. However, whether the NT3/TrkC-mediated signaling pathways are involved in Mn-induced apoptosis of cortical neurons remains unknown. The present study was designed to investigate the interact ...
DOI:
10.1016/j.fct.2019.110925

13. Plant immune signaling: Advancing on two frontiers

Author:
Wang, Wei; Feng, Baomin; Zhou, Jian‐Min; Tang, Dingzhong
Source:
Journal of integrative plant biology 2020 v.62 no.1 pp. 2-24
ISSN:
1672-9072
Subject:
mitogen-activated protein kinase,   etc   ; calcium; immune response; interleukin-1; pathogens; receptors;     Show all 6 Subjects
Abstract:
... Plants have evolved multiple defense strategies to cope with pathogens, among which plant immune signaling that relies on cell‐surface localized and intracellular receptors takes fundamental roles. Exciting breakthroughs were made recently on the signaling mechanisms of pattern recognition receptors (PRRs) and intracellular nucleotide‐binding site (NBS) and leucine‐rich repeat (LRR) domain recepto ...
DOI:
10.1111/jipb.12898

14. The quaternary assembly of KRas4B with Raf-1 at the membrane

Author:
Jang, Hyunbum; Zhang, Mingzhen; Nussinov, Ruth
Source:
Computational and Structural Biotechnology Journal 2020 v.18 pp. 737-748
ISSN:
2001-0370
Subject:
mitogen-activated protein kinase,   etc   ; active sites; catalytic activity; cytoplasm; dimerization; nanoparticles; proteins;     Show all 7 Subjects
Abstract:
... Proximally located in the membrane, oncogenic Ras dimers (or nanoclusters) can recruit and promote Raf dimerization and MAPK (Raf/MEK/ERK) signaling. Among Ras isoforms, KRas4B is the most frequently mutated. Recent data on the binary KRas4B–Raf-1 complex suggested that Raf-1 CRD not only executes membrane anchorage, but also supports the high-affinity interaction of Raf-1 RBD with KRas4B catalyti ...
DOI:
10.1016/j.csbj.2020.03.018
PubMed:
32257057
PubMed Central:
PMC7125320

15. Nature of the Pre-Chemistry Ensemble in Mitogen-Activated Protein Kinases

Author:
Ghose, Ranajeet
Source:
Journal of molecular biology 2019 v.431 no.2 pp. 145-157
ISSN:
0022-2836
Subject:
mitogen-activated protein kinase,   etc   ; adenosine triphosphate; chemistry;     Show all 3 Subjects
Abstract:
... In spite of the availability of a significant amount of structural detail on docking interactions involving mitogen-activated protein kinases (MAPKs) and their substrates, the mechanism by which the disordered phospho-acceptor on the substrate transiently interacts with the kinase catalytic elements and is phosphorylated, often with high efficiency, remains poorly understood. Here, this dynamic in ...
DOI:
10.1016/j.jmb.2018.12.007

16. SERK Receptor-like Kinases Control Division Patterns of Vascular Precursors and Ground Tissue Stem Cells during Embryo Development in Arabidopsis

Author:
Li, Huiqiang; Cai, Zeping; Wang, Xiaojuan; Li, Meizhen; Cui, Yanwei; Cui, Nan; Yang, Fei; Zhu, Mingsong; Zhao, Junxiang; Du, Wenbin; He, Kai; Yi, Jing; Tax, Frans E.; Hou, Suiwen; Li, Jia; Gou, Xiaoping
Source:
Molecular plant 2019 v.12 no.7 pp. 984-1002
ISSN:
1674-2052
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase,   etc   ; Arabidopsis; genes; mutants; somatic embryogenesis; stem cells;     Show all 7 Subjects
Abstract:
... During embryo development, the vascular precursors and ground tissue stem cells divide to renew themselves and produce the vascular tissue, endodermal cells, and cortical cells. However, the molecular mechanisms regulating division of these stem cells have remained largely elusive. In this study, we show that loss of function of SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE (SERK) genes results in ab ...
DOI:
10.1016/j.molp.2019.04.011

17. Follicular fluid meiosis-activating sterol (FF-MAS) promotes meiotic resumption via the MAPK pathway in porcine oocytes

Author:
Guo, Ruijie; Wang, Xiaorong; Li, Qinghong; Sun, Xiaojiang; Zhang, Junlan; Hao, Ruirong
Source:
Theriogenology 2020 v.148 pp. 186-193
ISSN:
0093-691X
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase,   etc   ; embryogenesis; extrusion; follicular fluid; gene expression; gene expression regulation; genes; germinal vesicle; ketoconazole; meiosis; messenger RNA; protein synthesis; signal transduction; sterols; swine; transcription (genetics);     Show all 17 Subjects
Abstract:
... Follicular fluid meiosis-activating sterol (FF-MAS) exerts beneficial effects on the meiotic resumption of mammalian oocytes and their subsequent early embryonic development, but the signaling pathway underlying these effects has not been elucidated. Therefore, the objective of the present study was to investigate whether the mitogen-activated protein kinase (MAPK) pathway is involved in the FF-MA ...
DOI:
10.1016/j.theriogenology.2019.11.012

18. YODA-HSP90 Module Regulates Phosphorylation-Dependent Inactivation of SPEECHLESS to Control Stomatal Development under Acute Heat Stress in Arabidopsis

Author:
Samakovli, Despina; Tichá, Tereza; Vavrdová, Tereza; Ovečka, Miroslav; Luptovčiak, Ivan; Zapletalová, Veronika; Kuchařová, Anna; Křenek, Pavel; Krasylenko, Yuliya; Margaritopoulou, Theoni; Roka, Loukia; Milioni, Dimitra; Komis, George; Hatzopoulos, Polydefkis; Šamaj, Jozef
Source:
Molecular plant 2020 v.13 no.4 pp. 612-633
ISSN:
1674-2052
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase kinase,   etc   ; Arabidopsis; epistasis; guard cells; heat shock response; heat stress; heat-shock protein 90; ontogeny; plant adaptation; plant growth; protein phosphorylation; regulatory proteins; stomata; temperature; transcription factors;     Show all 16 Subjects
Abstract:
... Stomatal ontogenesis, patterning, and function are hallmarks of environmental plant adaptation, especially to conditions limiting plant growth, such as elevated temperatures and reduced water availability. The specification and distribution of a stomatal cell lineage and its terminal differentiation into guard cells require a master regulatory protein phosphorylation cascade involving the YODA mit ...
DOI:
10.1016/j.molp.2020.01.001

19. A Cell Wall Integrity–Related MAP Kinase Kinase Kinase AflBck1 Is Required for Growth and Virulence in Fungus Aspergillus flavus

Author:
Zhang, Feng; Huang, Luhua; Deng, Jili; Tan, Can; Geng, Longpo; Liao, Yun; Yuan, Jun; Wang, Shihua
Source:
Molecular plant-microbe interactions 2020 v.33 no.4 pp. 680-692
ISSN:
1943-7706
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase kinase,   etc   ; Aspergillus flavus; aflatoxins; carcinogenicity; cell walls; crops; epistasis; financial economics; fungi; genes; growth and development; mutants; pathogens; peanuts; reproduction; seeds; signal transduction; virulence;     Show all 19 Subjects
Abstract:
... Aspergillus flavus represents an important fungal pathogen, causing severe economic losses in crops. The mitogen-activated protein (MAP) kinase signaling pathway contributes to many physiological processes, but its precise role in A. flavus is not yet fully understood. In this study, we focused on the AflBck1 gene, which encodes a MAP kinase kinase kinase of the Slt2-MAPK pathway. Targeted deletio ...
DOI:
10.1094/MPMI-11-19-0327-R

20. Shenfu injection attenuates lipopolysaccharide-induced myocardial inflammation and apoptosis in rats

Author:
CHEN, Rui-Juan; RUI, Qing-Lin; WANG, Qiong; TIAN, Fang; WU, Jian; KONG, Xiang-Qing
Source:
Chinese journal of natural medicines 2020 v.18 no.3 pp. 226-233
ISSN:
1875-5364
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase,   etc   ; Oriental traditional medicine; apoptosis; blood serum; cardiomyocytes; cell viability; inflammation; interleukins; intraperitoneal injection; laboratory animals; lipopolysaccharides; protective effect; rats; sepsis (infection); signal transduction; tumor necrosis factor-alpha;     Show all 17 Subjects
Abstract:
... Shenfu injection (SFI), a Chinese medicinal product, shows potent efficacy in treating sepsis. The aim of the present study was to clarify the protective effects of SFI against lipopolysaccharide (LPS)-induced myocardial inflammation and apoptosis. Experiments were carried out in Sprague-Dawley (SD) rats treated with LPS or LPS + SFI, and in H9C2 cardiomyocytes. The sepsis-associated myocardial in ...
DOI:
10.1016/S1875-5364(20)30025-X