PubAg

Main content area

You searched for: Subject "mitogen-activated protein kinase" Remove constraint Subject: "mitogen-activated protein kinase"
Start Over

Search

8,847  Search Results

« Previous | 1 - 20 of 8,847 |
Number of results to display per page

Search Results

1. Nature of the Pre-Chemistry Ensemble in Mitogen-Activated Protein Kinases

Author:
Ghose, Ranajeet
Source:
Journal of molecular biology 2019 v.431 no.2 pp. 145-157
ISSN:
0022-2836
Subject:
mitogen-activated protein kinase,   etc   ; adenosine triphosphate; chemistry;     Show all 3 Subjects
Abstract:
... In spite of the availability of a significant amount of structural detail on docking interactions involving mitogen-activated protein kinases (MAPKs) and their substrates, the mechanism by which the disordered phospho-acceptor on the substrate transiently interacts with the kinase catalytic elements and is phosphorylated, often with high efficiency, remains poorly understood. Here, this dynamic in ...
DOI:
10.1016/j.jmb.2018.12.007

2. SERK Receptor-like Kinases Control Division Patterns of Vascular Precursors and Ground Tissue Stem Cells during Embryo Development in Arabidopsis

Author:
Li, Huiqiang; Cai, Zeping; Wang, Xiaojuan; Li, Meizhen; Cui, Yanwei; Cui, Nan; Yang, Fei; Zhu, Mingsong; Zhao, Junxiang; Du, Wenbin; He, Kai; Yi, Jing; Tax, Frans E.; Hou, Suiwen; Li, Jia; Gou, Xiaoping
Source:
Molecular plant 2019 v.12 no.7 pp. 984-1002
ISSN:
1674-2052
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase,   etc   ; Arabidopsis; genes; mutants; somatic embryogenesis; stem cells;     Show all 7 Subjects
Abstract:
... During embryo development, the vascular precursors and ground tissue stem cells divide to renew themselves and produce the vascular tissue, endodermal cells, and cortical cells. However, the molecular mechanisms regulating division of these stem cells have remained largely elusive. In this study, we show that loss of function of SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE (SERK) genes results in ab ...
DOI:
10.1016/j.molp.2019.04.011

3. Stressing out or stressing in: intracellular pathways for SAPK activation

Author:
Lee, Jongmin; Liu, Li; Levin, David E.
Source:
Current genetics 2019 v.65 no.2 pp. 417-421
ISSN:
0172-8083
Subject:
mitogen-activated protein kinase,   etc   ; DNA damage; arsenites; phosphorylation; yeasts;     Show all 5 Subjects
Abstract:
... Stress-activated MAP kinases (SAPKs) respond to a wide variety of stressors. In most cases, the pathways through which specific stress signals are transmitted to the SAPKs are not known. Our recent findings have begun to address two important and related questions. First, do various stresses activate a SAPK through common pathways initiated at the cell surface, or through alternative, intracellula ...
DOI:
10.1007/s00294-018-0898-5

4. Kinetic and mechanistic studies of p38α MAP kinase phosphorylation by MKK6

Author:
Wang, Yu‐Lu; Zhang, Yuan‐Yuan; Lu, Chang; Zhang, Wenhao; Deng, Haiteng; Wu, Jia‐Wei; Wang, Jue; Wang, Zhi‐Xin
Source:
TheFEBS journal 2019 v.286 no.5 pp. 1030-1052
ISSN:
1742-464X
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase,   etc   ; cell differentiation; dephosphorylation; models; phosphorylation; signal transduction; tyrosine; uncertainty; viscosity;     Show all 10 Subjects
Abstract:
... Bistability (coexistence of two stable steady states in a dynamical system) is a key mechanism of cellular decision‐making and has been observed in many biochemical reaction networks such as mitogen‐activated protein kinase (MAPK) signaling pathways. Theoretical studies have shown that bistability can arise in a single two‐site MAPK phosphorylation and dephosphorylation cycle. However, the bistabl ...
DOI:
10.1111/febs.14762

5. De‐ RSKing ERK – regulation of ERK1/2‐RSK dissociation by phosphorylation within a disordered motif

Author:
Kidger, Andrew M.; Cook, Simon J.
Source:
The FEBS journal 2018 v.285 no.1 pp. 42-45
ISSN:
1742-464X
Subject:
mitogen-activated protein kinase,   etc   ; dissociation; phosphates; phosphorylation;     Show all 4 Subjects
Abstract:
... The protein kinases ERK1/2 and RSK associate in unstimulated cells but must separate to target other substrates. In this issue, Gógl et al. show that phosphorylation of RSK by active ERK1/2 culminates in the formation of an intramolecular charge clamp between Lys729 and the phosphate group on Ser732. This promotes the dissociation of ERK1/2 from RSK allowing them to engage with other targets. ...
DOI:
10.1111/febs.14344

6. The vaccine adjuvant MPLA activates glycolytic metabolism in mouse mDC by a JNK-dependent activation of mTOR-signaling

Author:
Blanco-Pérez, Frank; Goretzki, Alexandra; Wolfheimer, Sonja; Schülke, Stefan
Source:
Molecular immunology 2019 v.106 pp. 159-169
ISSN:
0161-5890
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase,   etc   ; culture media; cytokines; dendritic cells; dexamethasone; enzyme inhibitors; glucose; glycolysis; mice; rapamycin; secretion; vaccine adjuvants; vaccines;     Show all 14 Subjects
Abstract:
... The detoxified TLR4-ligand MPLA is a successfully used adjuvant in clinically approved vaccines. However, its capacity to activate glycolytic metabolism in mDC and the influence of MPLA-induced metabolic changes on cytokine secretion are unknown.To analyze the capacity of MPLA to activate mDC metabolism and the mechanisms contributing to MPLA-induced metabolism activation and cytokine secretion.C5 ...
DOI:
10.1016/j.molimm.2018.12.029

7. RLCKs Bridge Plant Immune Receptors and MAPK Cascades

Author:
Cui, Fuhao; Sun, Wenxian; Kong, Xiangpei
Source:
Trends in plant science 2018 v.23 no.12 pp. 1039-1041
ISSN:
1360-1385
Subject:
mitogen-activated protein kinase; mitogen-activated protein kinase kinase,   etc   ; immunologic receptors; signal transduction;     Show all 4 Subjects
Abstract:
... Receptor-like cytoplasmic kinases (RLCKs) and MAP kinase (MAPK) cascades function downstream of diverse pattern recognition receptors (PRRs) to transduce immune signals. Recent studies identified two MAPK kinase kinases that are directly activated by RLCKs, and filled in a gap in immune signal transduction between PRR activation and the MAPK cascades. ...
DOI:
10.1016/j.tplants.2018.10.002

8. Targeting pro-senescence mitogen activated protein kinase (Mapk) enzymes with bioactive natural compounds

Author:
Cano, Mercedes; Guerrero-Castilla, Angelica; Nabavi, Seyed Mohammad; Ayala, Antonio; Argüelles, Sandro
Source:
Food and chemical toxicology 2019 v.131 pp. 110544
ISSN:
0278-6915
Subject:
mitogen-activated protein kinase,   etc   ; bioactive compounds; cell senescence; diterpenoids; flavonoids; inflammation; longevity; mitogens; models; toxicology;     Show all 10 Subjects
Abstract:
... Aging is a multifactorial universal process characterized by a gradual decrease in physiological and biochemical functions. Given that life expectancy is on the rise, a better understanding of molecular mechanisms of the aging process is necessary in order to develop anti-aging interventions. Uncontrolled cellular senescence promotes persistent inflammation and accelerates the aging process by dec ...
DOI:
10.1016/j.fct.2019.05.052

9. Herbacetin suppressed MMP9 mediated angiogenesis of malignant melanoma through blocking EGFR-ERK/AKT signaling pathway

Author:
Li, Lei; Fan, Pengfei; Chou, Haiyan; Li, Juan; Wang, Kai; Li, Hao
Source:
Biochimie 2019 v.162 pp. 198-207
ISSN:
0300-9084
Subject:
mitogen-activated protein kinase,   etc   ; angiogenesis; antineoplastic activity; drugs; flavonoids; humans; melanoma; phosphorylation; signal transduction; therapeutics;     Show all 10 Subjects
Abstract:
... Malignant melanoma remains a challenge for clinical practice and novel therapeutic strategies are urgently needed. Herbacetin, a natural flavonoid compound that has multiple pharmacological activities, exerts anticancer effects on several human tumors. In this study, the anti-angiogenesis effect of Herbacetin in human malignant melanoma was investigated. The results indicated that Herbacetin treat ...
DOI:
10.1016/j.biochi.2019.05.003

10. Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling

Author:
Lun, Xiao-Kang; Szklarczyk, Damian; Gábor, Attila; Dobberstein, Nadine; Zanotelli, Vito Riccardo Tomaso; Saez-Rodriguez, Julio; von Mering, Christian; Bodenmiller, Bernd
Source:
Molecular cell 2019 v.74 no.5 pp. 1086-1102.e5
ISSN:
1097-2765
Subject:
mitogen-activated protein kinase,   etc   ; carcinogenesis; disease course; drug resistance; drugs; humans; melanoma; mutation; proteins; proteomics; tyrosine;     Show all 11 Subjects
Abstract:
... Kinase and phosphatase overexpression drives tumorigenesis and drug resistance. We previously developed a mass-cytometry-based single-cell proteomics approach that enables quantitative assessment of overexpression effects on cell signaling. Here, we applied this approach in a human kinome- and phosphatome-wide study to assess how 649 individually overexpressed proteins modulated cancer-related sig ...
DOI:
10.1016/j.molcel.2019.04.021

11. Ribophorin II potentiates P-glycoprotein- and ABCG2-mediated multidrug resistance via activating ERK pathway in gastric cancer

Author:
Zhang, Hongzhi; Jiang, Huijuan; Zhang, Huixiang; Liu, Juncai; Hu, Xigang; Chen, Lei
Source:
International journal of biological macromolecules 2019 v.128 pp. 574-582
ISSN:
0141-8130
Subject:
mitogen-activated protein kinase,   etc   ; P-glycoproteins; adenosine triphosphate; drug therapy; multiple drug resistance; stomach neoplasms;     Show all 6 Subjects
Abstract:
... Multidrug resistance (MDR) is a critical reason of cancer chemotherapy failure. Ribophorin II (RPN2) has emerged as a vital regulator of MDR in multiple cancers including gastric cancer (GC). However, the roles and molecular mechanisms of RPN2 in MDR have not been well featured till now. The present study aimed to explore the roles and molecular mechanisms of RPN2 in MDR of drug-resistant GC cells ...
DOI:
10.1016/j.ijbiomac.2019.01.195

12. Transcriptional regulation of the Ciona Gsx gene in the neural plate

Author:
Hudson, Clare; Esposito, Rosaria; Palladino, Antonio; Staiano, Leopoldo; Ferrier, David; Faure, Emmanuel; Lemaire, Patrick; Yasuo, Hitoyoshi; Spagnuolo, Antonietta
Source:
Developmental biology 2019 v.448 no.2 pp. 88-100
ISSN:
0012-1606
Subject:
mitogen-activated protein kinase,   etc   ; Ciona; brain; gene overexpression; models; signal transduction; transcription (genetics); transcription initiation site;     Show all 8 Subjects
Abstract:
... The ascidian neural plate consists of a defined number of identifiable cells organized in a grid of rows and columns, representing a useful model to investigate the molecular mechanisms controlling neural patterning in chordates. Distinct anterior brain lineages are specified via unique combinatorial inputs of signalling pathways with Nodal and Delta-Notch signals patterning along the medial-later ...
DOI:
10.1016/j.ydbio.2018.12.013

13. High throughput scaffold-based 3D micro-tumor array for efficient drug screening and chemosensitivity testing

Author:
Yan, Xiaojun; Zhou, Lyu; Wu, Zhaozhao; Wang, Xun; Chen, Xiuyuan; Yang, Fan; Guo, Yanan; Wu, Min; Chen, Yuyang; Li, Wenjing; Wang, Jun; Du, Yanan
Source:
Biomaterials 2019 v.198 pp. 167-179
ISSN:
0142-9612
Subject:
mitogen-activated protein kinase,   etc   ; cell lines; cytotoxicity; doxorubicin; genes; lung neoplasms; mice; neoplasm cells; screening; therapeutics;     Show all 10 Subjects
Abstract:
... Oncology drug development is greatly hampered by inefficient drug screening using 2D culture. Herein, we present ready-to-use micro-scaffolds in 384-well format to generate uniform 3D micro-tumor array (3D-MTA, CV < 0.15) that predicts in vivo drug responses more accurately than 2D monolayer. 3D-MTA generated from both cell lines and primary cells achieved high screen quality (Z’ > 0.5), and were ...
DOI:
10.1016/j.biomaterials.2018.05.020

14. HOXA5 overexpression promotes osteosarcoma cell apoptosis through the p53 and p38α MAPK pathway

Author:
Chen, Yan-Qiang; Yang, Tong-Qun; Zhou, Bin; Yang, Ming-Xuan; Feng, Hai-Jun; Wang, Yu-Liang
Source:
Gene 2019 v.689 pp. 18-23
ISSN:
0378-1119
Subject:
mitogen-activated protein kinase,   etc   ; adolescents; apoptosis; caspase-3; cell viability; children; humans; osteoblasts; osteosarcoma;     Show all 9 Subjects
Abstract:
... Osteosarcoma is the most common malignant bone tumor in children and adolescents. Aberrant expression of HOXA5 results in various diseases, including cancers. However, the specific function and molecular mechanism of HOXA5 in osteosarcoma is not fully understood. In the present study, we focused on HOXA5 in U2OS and MG63 cells in vitro. We observed lower expression of HOXA5 in U2OS, MG63, and SaOS ...
DOI:
10.1016/j.gene.2018.11.081

15. Active avoidance learning differentially activates ERK phosphorylation in the primary auditory and visual cortices of Roman high- and low-avoidance rats

Author:
Sabariego, Marta; Rosas, Michela; Piludu, Maria Antonietta; Acquas, Elio; Giorgi, Osvaldo; Corda, Maria G.
Source:
Physiology & behavior 2019 v.201 pp. 31-41
ISSN:
0031-9384
Subject:
mitogen-activated protein kinase,   etc   ; amygdala; animal behavior; anxiety; avoidance conditioning; learning; neurons; phosphorylation; prefrontal cortex; rats;     Show all 10 Subjects
Abstract:
... Understanding the mechanisms underlying conditioned avoidance is a critical step toward the development of novel treatments of anxiety. In this context, the two-way active avoidance (2WAA) task is a validated paradigm to investigate uncontrolled avoidance, a hallmark of anxiety disorders. The outbred Roman high- (RHA) and low-avoidance (RLA) rat lines are selected for respectively rapid vs. poor a ...
DOI:
10.1016/j.physbeh.2018.12.009

16. Effect of EGF on expression and localization of maturation‐promoting factor, mitogen‐activated protein kinase, p34cdc2 and cyclin B during different culture periods on in vitro maturation of canine oocytes

Author:
Pereira, Leda Maria C.; Bersano, Paulo Ricardo O.; Rocha, Danilo D.; Lopes, Maria Denise
Source:
Reproduction in domestic animals 2019 v.54 no.2 pp. 325-341
ISSN:
0936-6768
Subject:
mitogen-activated protein kinase,   etc   ; cyclins; dogs; fluorescent antibody technique; maturation-promoting factor; meiosis; oocytes; signal transduction;     Show all 8 Subjects
Abstract:
... This study aimed to investigate the localization of MPF, MAPK, p34ᶜᵈᶜ² and cyclin B1 proteins, before and after treatment with EGF during different moments of oocyte maturation. The ovaries obtained from 350 domestic dogs were aseptically isolated, immersed in physiological solution and transported at 4°C. In the laboratory, the ovaries were sectioned for the release of cumulus–oocyte complexes. C ...
DOI:
10.1111/rda.13365

17. USP25 promotes endotoxin tolerance via suppressing K48-linked ubiquitination and degradation of TRAF3 in Kupffer cells

Author:
Wen, Jian; Bai, He; Chen, Nan; Zhang, Wenfeng; Zhu, Xiwen; Li, Peizhi; Gong, Jianping
Source:
Molecular immunology 2019 v.106 pp. 53-62
ISSN:
0161-5890
Subject:
mitogen-activated protein kinase,   etc   ; Kupffer cells; endotoxins; multiprotein complexes; tumor necrosis factors; ubiquitination;     Show all 6 Subjects
Abstract:
... The inhibition of tumor necrosis factor receptor-associated factor 3 (TRAF3) degradation induces endotoxin tolerance (ET) in macrophages. However, the mechanisms leading to TRAF3 inhibition by ET are largely unknown. Here, we found that ubiquitin-specific peptidase 25 (USP25), a deubiquitinating enzyme (DUB), interacted with TRAF3 and stabilized ET in Kupffer cells (KCs). Lentiviral knockdown of U ...
DOI:
10.1016/j.molimm.2018.12.017

18. Rapid effect of bisphenol A on glutamate-induced Ca2+ influx in hippocampal neurons of rats

Author:
Zhong, Xiaoyu; Li, Jishui; Zhuang, Ziwei; Shen, Qiaoqiao; Jiang, Kesheng; Hu, Yizhong; Wu, Donghong; Xu, Xiaohong
Source:
Molecular and cellular endocrinology 2019
ISSN:
0303-7207
Subject:
mitogen-activated protein kinase,   etc   ; antagonists; bisphenol A; calcium; calcium signaling; estrogens; fluorescence; hippocampus; neurons; neuroplasticity; rats;     Show all 11 Subjects
Abstract:
... Intracellular Ca2+ signaling plays an essential role in synaptic plasticity. This study examined the effect of BPA on concentration of intracellular Ca2+ ([Ca2+]i) by measuring fluorescence intensity of Ca2+ in hippocampal neurons in vitro. The results showed that BPA for 30 min exerted dose-dependently dual effects on glutamate-elevated [Ca2+]i: BPA at 1–10 μM suppressed but at 1–100 nM enhanced ...
DOI:
10.1016/j.mce.2019.01.024

19. Granisetron protects polymicrobial sepsis-induced acute lung injury in mice

Author:
Wang, Jun; Gong, Shenhai; Wang, Fangzhao; Niu, Mengwei; Wei, Guoquan; He, Zhanke; Gu, Tanwei; Jiang, Yong; Liu, Aihua; Chen, Peng
Source:
Biochemical and biophysical research communications 2019 v.508 no.4 pp. 1004-1010
ISSN:
0006-291X
Subject:
mitogen-activated protein kinase,   etc   ; drug therapy; drugs; inflammasomes; lipopolysaccharides; lungs; macrophages; mice; mortality; neutrophils; patients;     Show all 11 Subjects
Abstract:
... Sepsis is a serious condition with a high mortality rate worldwide. Granisetron is an anti-nausea drug for patients undergoing chemotherapy. Here we aimed to identify the novel effect of granisetron on sepsis-induced acute lung injury (ALI). Our results showed that mice treated with granisetron displayed less severe lung damage than controls. Granisetron administration reduced pulmonary neutrophil ...
DOI:
10.1016/j.bbrc.2018.12.031

20. Live-cell imaging and profiling of c-Jun N-terminal kinases using covalent inhibitor-derived probes

Author:
Qian, Linghui; Pan, Sijun; Lee, Jun-Seok; Ge, Jingyan; Li, Lin; Yao, Shao Q.
Source:
Chemical communications 2019 v.55 no.8 pp. 1092-1095
ISSN:
1364-548X
Subject:
mitogen-activated protein kinase,   etc   ; chemical compounds; chemical reactions; fluorescence; image analysis;     Show all 5 Subjects
Abstract:
... c-Jun N-terminal kinases (JNKs) are involved in critical cellular functions. Herein, small-molecule JNK-targeting probes are reported based on a covalent inhibitor. Together with newly developed two-photon fluorescence Turn-ON reporters and chemoproteomic studies, we showed that some probes may be suitable for live-cell imaging and profiling of JNKs. ...
DOI:
10.1039/c8cc09558b