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1. To Divide or Differentiate: It Is about Scaffolding

Author:
Guo, Xiaoyu; Dong, Juan
Source:
Trends in plant science 2019 v.24 no.6 pp. 481-484
ISSN:
1360-1385
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; Arabidopsis; cell differentiation; cell division; proteins; stomata;     Show all 6 Subjects
Abstract:
... Arabidopsis plants have specific polarized proteins, BASL and POLAR, that regulate stomatal asymmetric cell division (ACD). Earlier work established that BASL recruits YODA kinase (MAPKKK4) to suppress stomatal ACD in postmitotic cells. Houbaert et al. (Nature 2018;563:574–578) recently showed that POLAR scaffolds BIN2/GSK3s to promote stomatal ACD in premitotic cells. ...
DOI:
10.1016/j.tplants.2019.03.007

2. Fisetin activates Hippo pathway and JNK/ERK/AP‐1 signaling to inhibit proliferation and induce apoptosis of human osteosarcoma cells via ZAK overexpression

Author:
Fu, Chien‐Yao; Chen, Mei‐Chih; Tseng, Yan‐Shen; Chen, Ming‐Cheng; Zhou, Zhengtao; Yang, Jaw‐Ji; Lin, Yueh‐Min; Viswanadha, Vijaya P.; Wang, Guiqing; Huang, Chih‐Yang
Source:
Environmental toxicology 2019 v.34 no.8 pp. 902-911
ISSN:
1520-4081
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; apoptosis; cell growth; drug therapy; flavonols; fruits; humans; leucine zipper; mitogen-activated protein kinase; neoplasm cells; osteosarcoma; prognosis; vegetables;     Show all 13 Subjects
Abstract:
... Osteosarcoma (OS) is a tumor entity that can cause a large number of cancer‐related deaths. Although chemotherapy can decrease proliferation and increase apoptosis of human OS cells, the clinical prognosis remains poor. Fisetin is a flavonol found in fruits and vegetables and is reported to inhibit cell growth in numerous cancers. But the molecular mechanism underlying fisetin in human OS cells is ...
DOI:
10.1002/tox.22761

3. Soybean processing wastewater supported the removal of propyzamide and biochemical accumulation from wastewater by Rhodopseudomonas capsulata

Author:
Wu, Pan; Han, Ziqiao; Mo, Wentao; Wu, Xiaozhen; Chen, Zhaobo; Zhang, Ying; Wang, Yanling; Cui, Yubo; Dong, Yuying; Sun, Hongjie; Zou, Xuejun
Source:
Bioprocess and biosystems engineering 2019 v.42 no.8 pp. 1375-1384
ISSN:
1615-7591
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; Rhodobacter capsulatus; Rhodobacter sphaeroides; carbon; gene expression; genes; mathematical models; mitogen-activated protein kinase; propyzamide; signal transduction; sludge; soybeans; wastewater; wastewater treatment;     Show all 14 Subjects
Abstract:
... Simultaneous (SPW and propyzamide) wastewater treatment and the production of biochemicals by Rhodopseudomonas capsulata (R. capsulata) were investigated with supplement of soybean processing wastewater (SPW). Compared to control group, propyzamide was removed and biochemicals production were enhanced with the supplement of SPW. Propyzamide induced camH gene expression through activating MAPKKKs g ...
DOI:
10.1007/s00449-019-02137-2

4. Parallel-Reaction-Monitoring-Based Proteome-Wide Profiling of Differential Kinase Protein Expression during Prostate Cancer Metastasis in Vitro

Author:
Miao, Weili; Yuan, Jun; Li, Lin; Wang, Yinsheng
Source:
Analytical chemistry 2019 v.91 no.15 pp. 9893-9900
ISSN:
1520-6882
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; drugs; gene expression regulation; humans; men; metalloproteinases; metastasis; neoplasm cells; prostatic neoplasms; protein synthesis; proteins; proteomics; proto-oncogenes; therapeutics;     Show all 14 Subjects
Abstract:
... Prostate cancer is the most common type of cancer in men, and kinases are heavily pursued as drug targets for anticancer therapy. In this study, we applied our recently reported parallel-reaction-monitoring (PRM)-based targeted proteomic method to examine the reprogramming of the human kinome associated with bone metastasis of prostate cancer in vitro. The method displayed superior sensitivity ove ...
DOI:
10.1021/acs.analchem.9b01561

5. miR-222 regulates proliferation of primary mouse hepatocytes in vitro

Author:
Higashi, Miki; Yoneda, Mitsuhiro; Nakagawa, Takeya; Ikeda, Masaaki; Ito, Takashi
Source:
Biochemical and biophysical research communications 2019 v.511 no.3 pp. 644-649
ISSN:
0006-291X
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; cell proliferation; gene expression regulation; gene overexpression; genes; hepatectomy; hepatocytes; liver; mice; microRNA; neoplasms; sequence analysis;     Show all 12 Subjects
Abstract:
... It is well known that hepatocytes regenerate after liver injury, although it is difficult to reproduce this phenomenon in vitro. The goal of this research was to determine the factors that stimulate proliferation of primary mouse hepatocytes (PMHs) in vitro. We first tested knockdown (KD) of tumor protein 53 (p53) alone as well as partial hepatectomy (PH, performed 72 h prior to PMHs preparation) ...
DOI:
10.1016/j.bbrc.2019.02.093

6. The RAF‐like mitogen‐activated protein kinase kinase kinases RAF22 and RAF28 are required for the regulation of embryogenesis in Arabidopsis

Author:
Wang, Bo; Liu, Guting; Zhang, Jing; Li, Yuan; Yang, Hailian; Ren, Dongtao
Source:
Theplant journal 2018 v.96 no.4 pp. 734-747
ISSN:
0960-7412
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; Arabidopsis; auxins; cell division; embryogenesis; mutants; phenotype; pituitary gland; transporters;     Show all 9 Subjects
Abstract:
... In Arabidopsis, embryonic development follows a stereotypical pattern of cell division. Although many factors have been reported to participate in establishment of the proper embryonic pattern, the molecular mechanisms underlying pattern formation are unclear. In this study we showed that RAF22 and RAF28, two RAF‐like mitogen‐activated protein kinase kinase kinases (MAPKKKs) in Arabidopsis, are in ...
DOI:
10.1111/tpj.14063

7. The Solanum chacoense Fertilization-Related Kinase 3 (ScFRK3) is involved in male and female gametophyte development

Author:
Daigle, Caroline; Mazin, Benjamin; Matton, Daniel P.
Source:
BMC plant biology 2019 v.19 no.1 pp. 202
ISSN:
1471-2229
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; RNA interference; Solanum chacoense; death; embryo sac; evolution; females; fruits; gametophytes; males; meiosis; mitogen-activated protein kinase; mitosis; mutants; pollen; potatoes; seeds; transcriptome;     Show all 18 Subjects
Abstract:
... BACKGROUND: The Fertilization-related kinases (FRK) form a class that belongs to the MEKK subfamily of plant MAPKKKs. It was recently shown that FRK class kinases expanded during angiosperm evolution, reaching their maximum numbers in the lineage leading to solanaceous species and culminating in the Solanum genus where they account for more than 40% of the total MEKKs. The first members studied, S ...
DOI:
10.1186/s12870-019-1804-0

8. Phylogenetically conserved TAK1 participates in Branchiostoma belcheri innate immune response to LPS stimulus

Author:
Cao, Yunpeng; Jin, Na; Fan, Mingli; Lv, Caiyun; Song, Xiaojun; Jin, Ping; Ma, Fei
Source:
Fish & shellfish immunology 2019 v.94 pp. 264-270
ISSN:
1050-4648
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; Chordata; cecum; complementary DNA; genes; gills; innate immunity; muscles; open reading frames; phylogeny; precipitin tests; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; transforming growth factor beta;     Show all 14 Subjects
Abstract:
... Transforming growth factor-β activated kinase-1 (TAK1) is an important member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, which plays an important role in animal innate immune response. However, the TAK1 gene has yet not been reported in amphioxus to date. Here, we have identified and characterized a TAK1 gene from amphioxus (Branchiostoma belcheri) (named as AmphiTAK1) w ...
DOI:
10.1016/j.fsi.2019.09.020

9. OstMAPKKK5, a truncated mitogen-activated protein kinase kinase kinase 5, positively regulates plant height and yield in rice

Author:
Liu, Yahui; Zhu, Yu; Xu, Xuding; Sun, Fan; Yang, Jingshui; Cao, Liming; Luo, Xiaojin
Source:
The crop journal 2019 v.7 no.5 pp. 707-714
ISSN:
2214-5141
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; Oryza sativa; agronomic traits; cultivars; developmental stages; food crops; gene overexpression; genes; gibberellins; panicles; plant height; quantitative polymerase chain reaction; rice; tissues; transgenic plants;     Show all 15 Subjects
Abstract:
... Rice (Oryza sativa L.) is a major food crop worldwide. Plant height and yield are important agronomic traits of rice. Several genes regulating plant height and/or yield have been cloned. However, the molecular mechanisms coordinating plant height and yield are not fully characterized. Here, we report a novel gene, OstMAPKKK5 that encodes a truncated variant of a mitogen-activated protein kinase ki ...
DOI:
10.1016/j.cj.2019.03.001

10. Rhodopseudomonas palustris wastewater treatment: Cyhalofop-butyl removal, biochemicals production and mathematical model establishment

Author:
Wu, Pan; Chen, Zhaobo; Zhang, Ying; Wang, Yanling; Zhu, Feifei; Cao, Bo; Wu, Yuan; Li, Ning
Source:
Bioresource technology 2019 v.282 pp. 390-397
ISSN:
0960-8524
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; Rhodopseudomonas palustris; bacteriochlorophyll; carbon; carboxylesterase; carotenoids; chemical oxygen demand; gene expression; genes; mathematical models; mitogen-activated protein kinase; signal transduction; single cell protein; soybeans; wastewater; wastewater treatment;     Show all 16 Subjects
Abstract:
... Simultaneous (SPW and cyhalofop-butyl) wastewater treatment and the production of biochemicals by Rhodopseudomonas palustris (R. palustris) was investigated with supplementation of soybean processing wastewater (SPW). Compared to control group, cyhalofop-butyl was removed and single cell protein, carotenoid, bacteriochlorophyll productions were enhanced with the supplementation of SPW. Cyhalofop-b ...
DOI:
10.1016/j.biortech.2018.11.087

11. Apoptosis signal-regulating kinase (ASK1) and transcription factor tumor suppressor protein TP53 suppress rabbit ovarian granulosa cell functions

Author:
Sirotkin, Alexander V.; Petrak, Juraj; Alwasel, Saleh; Harrath, Abdel Halim
Source:
Animal reproduction science 2019 v.204 pp. 140-151
ISSN:
0378-4320
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; apoptosis; cell proliferation; granulosa cells; immunocytochemistry; insulin-like growth factor I; progesterone; proliferating cell nuclear antigen; rabbits; radioimmunoassays; transcription factors; transfection; tumor suppressor proteins;     Show all 13 Subjects
Abstract:
... This study was conducted with the aim to understand the roles of apoptosis signal-regulating kinase (ASK1) and transcription factor tumor suppressor protein TP53, as well as the possible interrelationships, in the control of healthy ovarian cell functions. Rabbit ovarian granulosa cells were transfected with constructs encoding ASK1, TP53, or TP53 + ASK1 and cultured with or without insulin-like g ...
DOI:
10.1016/j.anireprosci.2019.03.018

12. c-Raf participates in adaptive immune response of Nile tilapia via regulating lymphocyte activation

Author:
Wei, Xiumei; Zhao, Tianyu; Ai, Kete; Zhang, Yu; Li, Huiying; Yang, Jialong
Source:
Fish & shellfish immunology 2019 v.86 pp. 507-515
ISSN:
1050-4648
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; Aeromonas hydrophila; Oreochromis niloticus; T-lymphocytes; Western blotting; agonists; catalytic activity; evolution; fish; gene expression regulation; lymphocyte proliferation; messenger RNA; mitogen-activated protein kinase; mitogens; phosphorylation; protein kinase C; proto-oncogenes; tissues;     Show all 18 Subjects
Abstract:
... RAF proto-oncogene serine/threonine-protein kinase (c-Raf) is a MAP kinase kinase kinase (MAPKKK) that participates in the Erk1/2 pathway and plays an important role in lymphocyte activation. However, the study on how c-Raf regulates adaptive immunity in non-mammal is still limited. In present study, based on analysis of sequence characteristics of c-Raf from Oreochromis niloticus (On-c-Raf), we i ...
DOI:
10.1016/j.fsi.2018.11.072

13. Doxorubicin induces ZAKα overexpression with a subsequent enhancement of apoptosis and attenuation of survivability in human osteosarcoma cells

Author:
Fu, Chien‐Yao; Tseng, Yan‐Shen; Chen, Ming‐Cheng; Hsu, Hsi‐Hsien; Yang, Jaw‐Ji; Tu, Chuan‐Chou; Lin, Yueh‐Min; Viswanadha, Vijaya Padma; Kuo, Wei‐Wen; Huang, Chih‐Yang
Source:
Environmental toxicology 2018 v.33 no.2 pp. 191-197
ISSN:
1520-4081
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; RNA; apoptosis; cell proliferation; cell viability; doxorubicin; drug therapy; humans; osteosarcoma;     Show all 9 Subjects
Abstract:
... Human osteosarcoma (OS) is a malignant cancer of the bone. It exhibits a characteristic malignant osteoblastic transformation and produces a diseased osteoid. A previous study demonstrated that doxorubicin (DOX) chemotherapy decreases human OS cell proliferation and might enhance the relative RNA expression of ZAK. However, the impact of ZAKα overexpression on the OS cell proliferation that is inh ...
DOI:
10.1002/tox.22507

14. Detection of genomic regions underlying resistance to gastrointestinal parasites in Australian sheep

Author:
Al Kalaldeh, Mohammad; Gibson, John; Lee, Sang Hong; Gondro, Cedric; van der Werf, Julius H. J.
Source:
Genetics, selection, evolution 2019 v.51 no.1 pp. 37
ISSN:
1297-9686
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; Haemonchus contortus; Teladorsagia circumcincta; Trichostrongylus colubriformis; adaptive immunity; chromosomes; cytokines; eggs; feces; gastrointestinal parasites; genetic variation; genome-wide association study; genomics; genotyping; hemostasis; heritability; immune response; major genes; parasites; sheep; single nucleotide polymorphism arrays; Australia;     Show all 22 Subjects
Abstract:
... BACKGROUND: This study aimed at identifying genomic regions that underlie genetic variation of worm egg count, as an indicator trait for parasite resistance in a large population of Australian sheep, which was genotyped with the high-density 600 K Ovine single nucleotide polymorphism array. This study included 7539 sheep from different locations across Australia that underwent a field challenge wi ...
DOI:
10.1186/s12711-019-0479-1

15. The bioremediation of metolachlor in soil using Rhodospirillum rubrum after wastewater treatment

Author:
Wu, Pan; Shi, Jiarong; Zhang, Ying; Wang, Yanling; Ou, Xiaoxia; Han, Ziqiao; Wu, Xiaozhen; Zhao, Rou; Yang, Weiguang
Source:
Journal of soils and sediments 2019 v.19 no.10 pp. 3534-3544
ISSN:
1439-0108
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; Rhodospirillum rubrum; bioremediation; cytochrome P-450; gene expression; herbicide residues; metolachlor; mitogen-activated protein kinase; potassium; regulator genes; reverse transcriptase polymerase chain reaction; signal transduction; soil; soil fertility; soil organic matter; soil sampling; soybeans; total nitrogen; total phosphorus; wastewater; wastewater treatment;     Show all 21 Subjects
Abstract:
... PURPOSE: Reliable and effective techniques for removing contaminants from soil are highly desirable. However, metolachlor residue bioremediation and soil fertility improvement by Rhodospirillum rubrum (R. rubrum) in effluent after wastewater treatment have not yet been investigated. The aims of this study were to investigate the feasibility of bioremediation of metolachlor residues in soil and soi ...
DOI:
10.1007/s11368-019-02279-6

16. The biodegradation of carbaryl in soil with Rhodopseudomonas capsulata in wastewater treatment effluent

Author:
Wu, Pan; Xie, Liying; Mo, Wentao; Wang, Bing; Ge, Hui; Sun, Xiaodong; Tian, Ying; Zhao, Rou; Zhu, Feifei; Zhang, Ying; Wang, Yanling
Source:
Journal of environmental management 2019
ISSN:
0301-4797
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; Rhodobacter capsulatus; Rhodobacter sphaeroides; acclimation; bacteria; biodegradation; carbaryl; carbon; effluents; energy; gene expression; gene induction; genes; hydrolases; mathematical models; mitogen-activated protein kinase; pollution; remediation; secretion; signal transduction; sludge; soil; soil fertility; soybeans; wastewater; wastewater treatment;     Show all 26 Subjects
Abstract:
... In this study, the effects of Rhodopseudomonas capsulata present in wastewater effluent on the biodegradation of carbaryl in soil and improvement of soil fertility were investigated. Compared to control treatment, carbaryl was removed efficiently and soil fertility was remediated with the addition of effluent containing R. capsulata. Molecular analysis revealed that carbaryl induced carbaryl hydro ...
DOI:
10.1016/j.jenvman.2019.06.127

17. Quantitative proteomics suggest a potential link between early embryonic death and trisomy 16

Author:
Yao, Ting; Hou, Haiyan; Liu, Guozhong; Wu, Jun; Qin, Zhe; Sun, Yang; Jin, Xiaohan; Chen, Jun; Chen, Yaqiong; Xu, Zhongwei
Source:
Reproduction, fertility, and development 2019 v.31 no.6 pp. 1116-1126
ISSN:
1031-3613
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; chromosomes; cytosol; embryonic mortality; gelatinase A; gene expression regulation; human chorionic gonadotropin; humans; immune response; immunoglobulin G; inflammation; interleukin-18; mitogen-activated protein kinase; neutrophils; patients; protein synthesis; proteomics; tissues; transforming growth factor beta 1; trisomics; tumor necrosis factor-alpha;     Show all 21 Subjects
Abstract:
... Activation of extracellular signal-regulated kinase (ERK) signalling, alteration of the uterine microenvironment and a reduction in human chorionic gonadotrophin production have been linked with fetal trisomy 16-induced early embryonic death (EED). However, the detailed biological mechanism of EED remains unclear. Using quantitative proteomics we successfully screened differentially expressed prot ...
DOI:
10.1071/RD17319

18. Soluble Sugar Accumulation Can Influence Seed Size via AN3–YDA Gene Cascade

Author:
Meng, Lai-Sheng; Xu, Meng-Ke; Li, Dan; Zhou, Ming-Ming; Jiang, Ji-Hong
Source:
Journal of agricultural and food chemistry 2017 v.65 no.20 pp. 4121-4132
ISSN:
1520-5118
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; Arabidopsis; genes; glucose; models; mutants; mutation; sucrose;     Show all 8 Subjects
Abstract:
... In higher plants, seed size is central to many aspects in evolutionary fitness and is a crucial agricultural trait. In this study, Arabidopsis an3 (angustifolia3) mutants present with increased seed size. Target-gene analysis revealed that YDA, which encodes a mitogen-activated protein kinase kinase kinase, is a target gene of AN3. Indeed, the loss of YDA function decreases seed size. Furthermore, ...
DOI:
10.1021/acs.jafc.7b00228

19. Pleiotropic properties of ASK1 General subjects

Author:
Sakauchi, Chihiro; Wakatsuki, Hiroaki; Ichijo, Hidenori; Hattori, Kazuki
Source:
Biochimica et biophysica acta 2017 v.1861 no.1 pp. 3030-3038
ISSN:
0304-4165
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; apoptosis; homeostasis; knockout mutants; oxidative stress; pathogenesis; tumor necrosis factor-alpha;     Show all 7 Subjects
Abstract:
... Apoptosis signal-regulating kinase 1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5), has the potential to induce cellular apoptosis under various physiological conditions. It has long been suggested that ASK1 is highly sensitive to oxidative stress and contributes substantially to apoptosis. However, recent studies have indicated that ASK1 has pleiotropic roles in ...
DOI:
10.1016/j.bbagen.2016.09.028

20. Genome-wide identification and expression pattern analysis under abiotic stress of mitogen-activated protein kinase genes in Pyropia yezoensis

Author:
Li, Chao; Kong, Fanna; Sun, Peipei; Bi, Guiqi; Li, Na; Mao, Yunxiang; Sun, Meijuan
Source:
Journal of applied phycology 2018 v.30 no.4 pp. 2561-2572
ISSN:
0921-8971
Subject:
mitogen-activated protein kinase kinase kinase,   etc   ; Pyropia yezoensis; abiotic stress; databases; gene expression regulation; genes; genome-wide association study; inventories; littoral zone; mitogen-activated protein kinase; mitogen-activated protein kinase kinase; phylogeny; proteins; rehydration; stress response; temperature; thyrotropin; transcriptomics;     Show all 18 Subjects
Abstract:
... The mitogen-activated protein kinase (MAPK) cascade is composed of three hierarchically organized protein kinases (MAP kinase kinase kinases, MAP kinase kinases, and MAPKs) and plays a vital role in regulating developmental processes and stress responses in plants. Pyropia yezoensis belongs to the old Rhodophyta and grows in intertidal zones. Although MAPKs have been well studied in some model pla ...
DOI:
10.1007/s10811-018-1412-7