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1. Expression of leukocyte immunoglobulin-like receptor subfamily B expression on immune cells in hepatocellular carcinoma

Author:
Fan, Jing; Li, Jiayan; Han, Jianbo; Zhang, Yufeng; Gu, Aidong; Song, Fangnan; Duan, Jie; Yin, Dandan; Wang, Lili; Yi, Yongxiang
Source:
Molecular immunology 2021 v.136 pp. 82-97
ISSN:
0161-5890
Subject:
monocytes,   etc   ; granulocytes; hepatoma; immunology;     Show all 4 Subjects
Abstract:
... Leukocyte immunoglobulin-like receptor subfamily B (LILRB) is a group of inhibitory receptors involved in innate immune mainly expressed on lymphoid and myelomonocytic cells. LILRB is proposed to serve as immune checkpoint like PD-1 and CTLA-4 for tumor treatment. We recently reported that the expression of LILRB2 in CD1c⁺ mDC from tumor tissue might suppress immune for HCC patients. However, the ...
DOI:
10.1016/j.molimm.2021.05.011

2. Antigen presentation by mouse monocyte-derived cells: Re-evaluating the concept of monocyte-derived dendritic cells

Author:
Coillard, Alice; Segura, Elodie
Source:
Molecular immunology 2021 v.135 pp. 165-169
ISSN:
0161-5890
Subject:
monocytes,   etc   ; antigen presentation; inflammation; mice; phenotype;     Show all 5 Subjects
Abstract:
... Antigen presentation is a key feature of classical dendritic cells (cDCs). Numerous studies have also reported in mouse that, upon inflammation, monocytes enter tissues and differentiate into monocyte-derived DCs (mo-DC) that have the ability to present antigens to T cells. However, a population of inflammatory cDCs sharing phenotypic features with mo-DC has been recently described, challenging th ...
DOI:
10.1016/j.molimm.2021.04.012

3. Modulation of Serum Protein Electrophoretic Pattern and Leukocyte Population in Horses Vaccinated against West Nile Virus

Author:
Arfuso, Francesca; Giudice, Elisabetta; Di Pietro, Simona; Piccione, Giuseppe; Giannetto, Claudia
Source:
Animals 2021 v.11 no.2
ISSN:
2076-2615
Subject:
monocytes,   etc   ; West Nile virus; electrophoresis; neutrophils; vaccines;     Show all 5 Subjects
Abstract:
... This study aimed to evaluate the hematological and serum protein electrophoretic profiles of horses after inactivated West Nile virus (WNV) vaccine administration. Blood samples were collected from 10 horses before (T0), after 24 h, 48 h, 72 h, 1 week, 2 weeks and 3 weeks (T1I, T2I, T3I, T4I, T5I and T6I) from the first WNV vaccine-dose administration, before the vaccine-booster (TPREII), and afte ...
DOI:
10.3390/ani11020477

4. Changes in the behaviour of monocyte subsets in acute post-traumatic sepsis patients

Author:
Gupta, Dablu Lal; Sharma, Ashok; Soni, Kapil Dev; Kazim, Syed Naqui; Bhoi, Sanjeev; Rao, D.N
Source:
Molecular immunology 2021 v.136 pp. 65-72
ISSN:
0161-5890
Subject:
monocytes,   etc   ; agonists; blood serum; cytokines; death; immunophenotyping; mortality; public health;     Show all 8 Subjects
Abstract:
... Trauma remains a major public health problem worldwide, marked as the fourth leading cause of death among all diseases. Trauma patients who survived at initial stages in the Emergency Department (ED), have significantly higher chances of mortality due to sepsis associated complications in the ICU at the later stage. There is paucity of literature regarding the role of circulating monocytes subsets ...
DOI:
10.1016/j.molimm.2021.04.005

5. New mAbs facilitate quantification of secreted equine TNF-α and flow cytometric analysis in monocytes and T cells

Author:
Schnabel, Christiane L.; Babasyan, Susanna; Freer, Heather; Larson, Elisabeth M.; Wagner, Bettina
Source:
Veterinary immunology and immunopathology 2021 v.238 pp. 110284
ISSN:
0165-2427
Subject:
monocytes,   etc   ; biomarkers; flow cytometry; fluorescence; horses; immunopathology; inflammation; necrosis; neoplasms;     Show all 9 Subjects
Abstract:
... Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine, that is involved in acute inflammation and is employed as a biomarker of inflammatory diseases in several species for which reliable quantification is available. We aimed to develop suitable tools to quantify TNF-α in equine samples. We generated two new mAbs against equine TNF-α (clones 48 and 292), evaluated their specificity for this cy ...
DOI:
10.1016/j.vetimm.2021.110284

6. Development of a rabbit monocyte activation test as an alternative to the rabbit pyrogen test and its application in the analysis of plasma-derived products

Author:
Kim, Ji-Hye; Jung, Kikyung; Kim, Jaeok; Lee, Jiyoung; Kim, HyunJeong; Song, Hojin; Han, Kiwon; Park, Sangmi; Ahn, Chiyoung; Kim, Chan-Wha
Source:
Biologicals 2021 v.71 pp. 20-30
ISSN:
1045-1056
Subject:
monocytes,   etc   ; endotoxins; humans; lipoteichoic acids; peptidoglycans; quality control; rabbits; zymosan;     Show all 8 Subjects
Abstract:
... The rabbit pyrogen test (RPT) is a safety test conducted as a part of mandatory requirements of regulatory agencies. RPT is currently performed for routine quality control (QC) by manufacturers and for national lot release of biological products, such as plasma-derived products. However, RPT involves the use of many rabbits, counter to the international efforts to minimize the use of animals in re ...
DOI:
10.1016/j.biologicals.2021.04.003

7. Monocyte monolayer assay in pre-transfusion testing: A magic key in transfusing patients with recurrent bad cross-match due to alloimmunization

Author:
El-sayed, Hebat Allah N.; Abdollah, Maha R.A.; Raafat, Shereen N.; Ragab, Dina
Source:
Journal of immunological methods 2021 v.492 pp. 112968
ISSN:
0022-1759
Subject:
monocytes,   etc   ; agglutination; antigens; autoantibodies; blood transfusion; cell culture; gels;     Show all 7 Subjects
Abstract:
... The monocyte monolayer assay (MMA) is an in-vitro assay that can predict the outcome of blood transfusion of antigen positive units when serologically compatible blood is not available.Fifty-four patients testing positive by the antibody screening test using gel agglutination were further examined by the alloantibody identification panel to determine alloantibody specificity. After determining and ...
DOI:
10.1016/j.jim.2021.112968

8. Heterogeneous populations from in vitro cultures of antigen presenting cells in pigs

Author:
Pujol, Myriam; Guzman, Efrain; Montaner-Tarbes, Sergio; Montoya, Maria
Source:
Veterinary immunology and immunopathology 2021 v.234 pp. 110215
ISSN:
0165-2427
Subject:
monocytes,   etc   ; antigens; bone marrow; immunopathology; macrophages; phenotype; swine;     Show all 7 Subjects
Abstract:
... Dendritic cells (DCs) are the most potent antigen presenting cells (APCs). Because of the difficulty in obtaining these cells directly from tissues, different sources of DCs are frequently used for in vitro experimentation and many of their biological and functional characteristics were studied using these systems. Until recently, it was assumed that specific culture conditions polarized the diffe ...
DOI:
10.1016/j.vetimm.2021.110215

9. Innate immune training and metabolic reprogramming in primary monocytes of broiler and laying hens

Author:
Verwoolde, Michel B.; van den Biggelaar, Robin H.G.A.; de Vries Reilingh, Ger; Arts, Joop A.J.; van Baal, Jürgen; Lammers, Aart; Jansen, Christine A.
Source:
Developmental and comparative immunology 2021 v.114 pp. 103811
ISSN:
0145-305X
Subject:
monocytes,   etc   ; disease resistance; inflammation; innate immunity; interleukin-4; lipopolysaccharides;     Show all 6 Subjects
Abstract:
... Recently, we have reported trained innate immunity in laying chicken monocytes. In the present study, we further investigated trained innate immunity of monocytes in layers and broilers. Monocytes of both breeds isolated from blood were trained in vitro with β-glucan, rec-chicken IL-4 or a combination of both, and restimulated with lipopolysaccharide (LPS), after which inflammation and metabolism- ...
DOI:
10.1016/j.dci.2020.103811

10. A review of current knowledge of myeloproliferative disorders in the horse

Author:
Satué, Katy; Gardon, Juan Carlos; Muñoz, Ana
Source:
Acta veterinaria scandinavica 2021 v.63 no.1 pp. 8
ISSN:
1751-0147
Subject:
monocytes,   etc   ; World Health Organization; bone marrow; eosinophils; hematopoiesis; horses; megakaryocytes; myeloid leukemia; neutrophils;     Show all 9 Subjects
Abstract:
... Myeloid disorders are conditions being characterized by abnormal proliferation and development of myeloid lineage including granulocytes (neutrophils, eosinophils and basophils), monocytes, erythroids, and megakaryocytes precursor cells. Myeloid leukemia, based on clinical presentation and proliferative rate of neoplastic cells, is divided into acute (AML) and myeloproliferative neoplasms (MPN). T ...
DOI:
10.1186/s13028-021-00573-3

11. Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2

Author:
Specht, Harrison; Emmott, Edward; Petelski, Aleksandra A.; Huffman, R. Gray; Perlman, David H.; Serra, Marco; Kharchenko, Peter; Koller, Antonius; Slavov, Nikolai
Source:
Genome biology 2021 v.22 no.1 pp. 50
ISSN:
1474-760X
Subject:
monocytes,   etc   ; automation; cytokines; genes; genomics; macrophages; neoplasms; proteome; proteomics; single cell protein; statistics; transcriptomics;     Show all 12 Subjects
Abstract:
... BACKGROUND: Macrophages are innate immune cells with diverse functional and molecular phenotypes. This diversity is largely unexplored at the level of single-cell proteomes because of the limitations of quantitative single-cell protein analysis. RESULTS: To overcome this limitation, we develop SCoPE2, which substantially increases quantitative accuracy and throughput while lowering cost and hands- ...
DOI:
10.1186/s13059-021-02267-5

12. CCL19 variants mediate chemotactic response via CCR7 in grass carp Ctenopharyngodon idella

Author:
Wei, Wei; Wang, Junya; Min, Qingyu; Jia, Zhao; Chen, Kangyong; Feng, Hao; Zou, Jun
Source:
Developmental and comparative immunology 2021 v.122 pp. 104127
ISSN:
0145-305X
Subject:
monocytes,   etc   ; Ctenopharyngodon idella; Flavobacterium columnare; Reoviridae; antigens; chemotaxis; fish; homeostasis; immunosuppression; inflammation; kidneys; ligands; macrophages; spleen;     Show all 14 Subjects
Abstract:
... CC chemokine ligand 19 (CCL19) plays a key role in the regulation of immune responses including homeostasis, inflammation, and immune tolerance. In this study, two variants of CCL19 homologues (CCL19a2 and CCL19b) and CCR7 were investigated in grass carp Ctenopharyngodon idella. The three genes were widely expressed in immune tissues and could be modulated by stimulation with LPS, PHA and poly(I:C ...
DOI:
10.1016/j.dci.2021.104127

13. Atypical hemograms of the commercial duck

Author:
Cotter, Paul F.
Source:
Poultry science 2021 v.100 no.8 pp. 101248
ISSN:
0032-5791
Subject:
monocytes,   etc   ; blood platelets; ducks; erythrocytes; fungi; heterophils; microscopy; plasma cells; polyploidy;     Show all 9 Subjects
Abstract:
... A description of standard and atypical heterophils, lymphocytes, and 2 types of giant cells found in the circulation of 17 wk commercial ducks (N = 24) in apparent good health is the subject. Heterophils were sorted as either “classic” (HC) having red rod-shaped cytoplasmic granules, “typical” (HT) having weakly stained granules providing a reticular cytoplasmic appearance, or rarely as “variant” ...
DOI:
10.1016/j.psj.2021.101248

14. Expression of CD9 on porcine lymphocytes and its relation to T cell differentiation and cytokine production

Author:
Milburn, Jemma V.; Hoog, Anna M.; Winkler, Simona; van Dongen, Katinka A.; Leitner, Judith; Patzl, Martina; Saalmüller, Armin; de Luca, Karelle; Steinberger, Peter; Mair, Kerstin H.; Gerner, Wilhelm
Source:
Developmental and comparative immunology 2021 v.121 pp. 104080
ISSN:
0145-305X
Subject:
monocytes,   etc   ; CD4-positive T-lymphocytes; antigens; biomedical research; cell differentiation; cytokines; influenza; swine;     Show all 8 Subjects
Abstract:
... In this work, we report on two novel monoclonal antibodies, specific for porcine CD9. CD9 is a tetraspanin that is expressed on a wide variety of cells. We phenotyped porcine immune cell subsets and found that CD9 was expressed on all monocytes as well as a subset of B cells. CD9 was variably expressed on T cells, with CD4 T cells containing the highest frequency of CD9⁺ cells. CD9 expression posi ...
DOI:
10.1016/j.dci.2021.104080

15. Expression of glucose and magnesium transport-associated genes in whole blood RNA of lactating ewes supplemented with magnesium

Author:
Ahmed, Mona H.; Sponder, Gerhard; Wilkens, Mirja R.; Schuberth, Hans-Joachim; Ganter, Martin; Breves, Gerhard; Aschenbach, Jörg R.
Source:
Livestock science 2021 v.250 pp. 104583
ISSN:
1871-1413
Subject:
monocytes,   etc   ; early lactation; energy; energy metabolism; gene expression; glucose; immune response; magnesium; magnesium oxide; neutrophils; pregnancy;     Show all 11 Subjects
Abstract:
... Lactation is characterized by an increase in energy demand and glucose consumption, which may also be linked to the concurrent compromise in immune function during early lactation. Magnesium (Mg) could be involved in this link based on its role for more than 600 metabolic reactions associated with energy metabolism, in addition to its essential role in glucose metabolism. Therefore, the current st ...
DOI:
10.1016/j.livsci.2021.104583

16. Immunocartography: Charting vaccine-driven immunity by applying single cell proteomics to an in vitro human model

Author:
Duprez, Jessica S.; Cohen, Michael; Li, Stephen; Wilson, Derek; Brookes, Roger H.; James, D. Andrew
Source:
Journal of immunological methods 2021 v.495 pp. 113083
ISSN:
0022-1759
Subject:
monocytes,   etc   ; T-lymphocytes; antigens; humans; immunologic memory; memory; proteomics; vaccine development; vaccines;     Show all 9 Subjects
Abstract:
... The ability to measure immunomodulatory effects of a vaccine is crucial for novel vaccine design. While traditional animal models have been effective, a better understanding of the response in humans to new vaccines in pre-clinical development is critical for advancement to clinical trials. A translational methodology that can capture the complexity of a vaccine-driven response in a human model, w ...
DOI:
10.1016/j.jim.2021.113083

17. Regulation of macrophage functions by FABP-mediated inflammatory and metabolic pathways

Author:
Jin, Rong; Hao, Jiaqing; Yi, Yanmei; Sauter, Edward; Li, Bing
Source:
Biochimica et biophysica acta 2021 v.1866 no.8 pp. 158964
ISSN:
1388-1981
Subject:
monocytes,   etc   ; fatty acids; homeostasis; immunomodulation; interleukin-4; liver; macrophage activation; macrophages; metabolism; phenotype; yolk sac;     Show all 11 Subjects
Abstract:
... Macrophages are almost everywhere in the body, where they serve pivotal functions in maintaining tissue homeostasis, remodeling, and immunoregulation. Macrophages are traditionally thought to differentiate from bone marrow-derived hematopoietic stem cells (HSCs). Emerging studies suggest that some tissue macrophages at steady state originate from embryonic precursors in the yolk sac or fetal liver ...
DOI:
10.1016/j.bbalip.2021.158964

18. Identification and expression analysis of group II C-type lectin domain containing receptors in grass carp Ctenopharyngodon idella

Author:
Jia, Zhao; Wang, Junya; Chen, Kangyong; Zhang, Qin; Sun, Zhaosheng; Hassan, Zeinab; Feng, Hao; Zou, Jun
Source:
Gene 2021 v.789 pp. 145668
ISSN:
0378-1119
Subject:
monocytes,   etc   ; Ctenopharyngodon idella; Flavobacterium columnare; fish; genes; immunologic receptors; innate immunity; kidneys; lectins; ligands; macrophages; spleen;     Show all 12 Subjects
Abstract:
... Group II C-type lectin domain (CTLD) containing receptors belong to a large family of pattern recognition receptors which mainly act on the innate immunity. They are structurally related and consist of a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and a single extracellular CTLD. Although they have been described in teleost fish, their involvement in immune responses is not w ...
DOI:
10.1016/j.gene.2021.145668

19. Is Probiotic and Synbiotic Supplementation Effective on Immune Cells? A Systematic Review and Meta-analysis of Clinical Trials

Author:
Kazemi, Asma; Soltani, Sepideh; Ghorabi, Sima; Nasri, Fatemeh; Babajafari, Sivash; Mazloomi, Seyed Mohammad
Source:
Food reviews international 2021 v.37 no.5 pp. 491-537
ISSN:
1525-6103
Subject:
monocytes,   etc   ; B-lymphocytes; CD4-positive T-lymphocytes; immunity; leukocyte count; meta-analysis; neutrophils; probiotics; systematic review;     Show all 9 Subjects
Abstract:
... Effect of probiotics on various parameters of immune system including immune cells count levels has been demonstrated by clinical trials; however, as far as we know, no meta-analysis has been done. The aim of this systematic review and meta-analysis was to evaluate the effect of probiotic/synbiotic on immune cells in health and disease status. We searched PubMed, SCOPUS, and Web of Science. All cl ...
DOI:
10.1080/87559129.2019.1710748

20. Monocytes promote pyroptosis of endothelial cells during lung ischemia-reperfusion via IL-1R/NF-κB/NLRP3 signaling

Author:
Zhou, Peng; Guo, Hui; Li, Yiqing; Liu, Quan; Qiao, Xinwei; Lu, Yuan; Mei, Pei-Yuan; Zheng, Zhikun; Li, Jinsong
Source:
Life sciences 2021 v.276 pp. 119402
ISSN:
0024-3205
Subject:
monocytes,   etc   ; caspase-1; coculture; edema; humans; ischemia; lungs; mice; models; pyroptosis; secretion;     Show all 11 Subjects
Abstract:
... In our previous study, we observed that donor pulmonary intravascular nonclassical monocytes play a major role in early PGF, but the specific mechanism remained unclear. In this study, we investigated the mechanistic role of monocytes in inducing pyroptosis of human pulmonary microvascular endothelial cells (HPMECs) during IRI. A murine hilar ligation model of IRI was utilized whereby left lungs u ...
DOI:
10.1016/j.lfs.2021.119402