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1. Formate hydrogenlyase, formic acid translocation and hydrogen production: dynamic membrane biology during fermentation

Author:
Katharina Peters; Frank Sargent
Source:
Biochimica et biophysica acta 2023 v.1864 no.1 pp. 148919
ISSN:
0005-2728
Subject:
mutation,   etc   ; Escherichia coli; fermentation; formate dehydrogenase; formates; formic acid; hydrogen; hydrogen production; oxidation; phenotype; quinones;     Show all 11 Subjects
Abstract:
... Formate hydrogenlyase-1 (FHL-1) is a complex-I-like enzyme that is commonly found in gram-negative bacteria. The enzyme comprises a peripheral arm and a membrane arm but is not involved in quinone reduction. Instead, FHL-1 couples formate oxidation to the reduction of protons to molecular hydrogen (H₂). Escherichia coli produces FHL-1 under fermentative conditions where it serves to detoxify formi ...
DOI:
10.1016/j.bbabio.2022.148919

2. Internal structure and thermal properties of potato starches varying widely in amylose content

Author:
Xue Zhao; Per Hofvander; Mariette Andersson; Roger Andersson
Source:
Food hydrocolloids 2023 v.135 pp. 108148
ISSN:
0268-005X
Subject:
mutation,   etc   ; amylopectin; amylose; anion exchange chromatography; calorimetry; dextrins; enthalpy; gel chromatography; gelatinization; hydrocolloids; polymerization; potatoes; retrogradation; starch synthase;     Show all 14 Subjects
Abstract:
... The correlation between starch internal structure and thermal properties (gelatinisation and retrogradation) was studied in starches of wild-type potatoes and potatoes from the lines with altered starch synthase or branching enzyme activities (GBSS, SS, SBE), representing a range of amylose:amylopectin ratio from 2 to >99.5% amylopectin. The different potato lines were divided into Group 1–8 depen ...
DOI:
10.1016/j.foodhyd.2022.108148

3. Anti-folate quintuple mutations in Plasmodium falciparum asymptomatic infections in Yaoundé, Cameroon

Author:
Rodrigue Roman Dongang Nana; Suzanne Sandrine Beack Bayengue; Martin Luther Koanga Mogtomo; Anne Rosalie Ngono Ngane; Vineeta Singh
Source:
Parasitology international 2023 v.92 pp. 102657
ISSN:
1383-5769
Subject:
mutation,   etc   ; Plasmodium falciparum; antimalarials; blood; chemoprevention; codons; dihydrofolate reductase; haplotypes; household surveys; malaria; microscopy; mutants; parasitemia; parasites; parasitology; therapeutics; Cameroon;     Show all 17 Subjects
Abstract:
... A major challenge in the fight to effectively control malaria is the emergence of resistant parasite to drugs used in therapy as well as for chemoprevention. In this study, single nucleotide polymorphisms (SNPs) associated with Plasmodium falciparum resistance to sulfadoxine-pyrimethamine (SP), one of the partner drugs in artemisinin-based therapies (ACTs) were studied in asymptomatic P. falciparu ...
DOI:
10.1016/j.parint.2022.102657

4. Ricin aptamer screening based on the QSAR model and construction of piezoresistive micro-cantilever aptasensor

Author:
Zhiwei Liu; Zhaoyang Tong; Bing Liu; Yuting Wu; Bin Du; Jiang Wang; Jianjie Xu; Chuan Gao; Shuai Liu; Wei Ma
Source:
Talanta 2023 v.252 pp. 123840
ISSN:
0039-9140
Subject:
mutation,   etc   ; aptasensors; crystal structure; deformation; detection limit; models; oligonucleotides; quantitative structure-activity relationships; ricin; synergism; systematic evolution of ligands by exponential enrichment;     Show all 11 Subjects
Abstract:
... Currently, many aptamers of different target molecules have been screened by systematic evolution of ligands by exponential enrichment (SELEX) method. However, since the crystal structure of aptamers is complicated to obtain, few studies focus on the quantitative structure activity relationship (QSAR) of aptamers. It is significant to develop a virtual screening method for aptamers based on the QS ...
DOI:
10.1016/j.talanta.2022.123840

5. Research progress of biosensors for detection of SARS-CoV-2 variants based on ACE2

Author:
Hongshuai Wei; Congcong Zhang; Xin Du; Zhenguo Zhang
Source:
Talanta 2023 v.251 pp. 123813
ISSN:
0039-9140
Subject:
mutation,   etc   ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antibodies; biosensors; drug development; human health; pandemic; rapid methods; reverse transcriptase polymerase chain reaction; viruses;     Show all 11 Subjects
Abstract:
... Currently, the coronavirus disease 2019 (COVID-19) pandemic is ravaging the world, causing serious crisis in economy and human health. The top priority is the detection and drug development of the novel coronavirus. The gold standard for real-time diagnosis of coronavirus disease is the reverse transcription-polymerase chain reaction (RT-PCR), which is usually operatively complex and time-consumin ...
DOI:
10.1016/j.talanta.2022.123813

6. Improving the catalytic efficiency of Pseudomonas aeruginosa lipoxygenase by semi-rational design

Author:
Cuiping Pang; Song Liu; Guoqiang Zhang; Jingwen Zhou; Guocheng Du; Jianghua Li
Source:
Enzyme and microbial technology 2023 v.162 pp. 110120
ISSN:
0141-0229
Subject:
mutation,   etc   ; Pseudomonas aeruginosa; amino acids; catalytic activity; decolorization; fatty acids; half life; hydroperoxides; industrial applications; lipoxygenases; medicine; molecular dynamics; mutants; peroxidation; structure-activity relationships; van der Waals forces;     Show all 16 Subjects
Abstract:
... Lipoxygenase (LOX) catalyzes the peroxidation of unsaturated fatty acids to produce hydroperoxides, which had been widely used in food, medicine and chemical industries due to its decoloration of food and conversion of renewable oils. Thus, higher catalytic activity and stability is desired for low-cost and expanded industrial applications of LOX. To improve the catalytic activity of LOX, a mutant ...
DOI:
10.1016/j.enzmictec.2022.110120

7. Evaluation of HIV-1 integrase variability by combining computational and probabilistic approaches

Author:
Davide Vergni; Daniele Santoni; Yagai Bouba; Saverio Lemme; Lavinia Fabeni; Luca Carioti; Ada Bertoli; William Gennari; Federica Forbici; Carlo Federico Perno; Roberta Gagliardini; Francesca Ceccherini-Silberstein; Maria Mercedes Santoro; on behalf of the HIV drug-resistance group
Source:
Infection, genetics, and evolution 2022 v.101 pp. 105294
ISSN:
1567-1348
Subject:
mutation; mutation rate,   etc   ; amino acids; bioinformatics; entropy; infection; integrases;     Show all 7 Subjects
Abstract:
... This study aimed at updating previous data on HIV-1 integrase variability, by using effective bioinformatics methods combining different statistical instruments from simple entropy and mutation rate to more specific approaches such as Hellinger distance. A total of 2133 HIV-1 integrase sequences were analyzed in: i) 1460 samples from drug-naïve [DN] individuals; ii) 386 samples from drug-experienc ...
DOI:
10.1016/j.meegid.2022.105294

8. Generation of fast growth Nile tilapia (Oreochromis niloticus) by myostatin gene mutation

Author:
You Wu; Tengfei Wu; Lanying Yang; Yun Su; Chenhua Zhao; Lu Li; Jing Cai; Xiangyan Dai; Deshou Wang; Linyan Zhou
Source:
Aquaculture 2023 v.562 pp. 738762
ISSN:
0044-8486
Subject:
mutation,   etc   ; CRISPR-Cas systems; Oreochromis niloticus; aquaculture; basement membrane; body size; body weight; brain; carp; condition factor; fins; fluorescence; gene expression; genes; growth performance; head; hybridization; males; mammals; muscles; mutants; myostatin; phenotype; phylogeny; sexual dimorphism; skeletal muscle; specific growth rate; weight gain;     Show all 28 Subjects
Abstract:
... Tilapia is the second most prolific species grown in aquaculture after carp, and is widely grown in >100 countries. Myostatin (MSTN) has been proved to be a negative regulator of skeletal muscle growth. Mutation of MSTN gene resulted in significant increase in both body size and muscle mass in vertebrates, mostly with a species-specific effect. To generate a new strain in Nile tilapia (Oreochromis ...
DOI:
10.1016/j.aquaculture.2022.738762

9. Who ever thought genetic mutations were random?

Author:
Reiner A. Veitia
Source:
Trends in plant science 2022 v.27 no.8 pp. 733-735
ISSN:
1360-1385
Subject:
mutation; mutation rate,   etc   ; Arabidopsis thaliana; essential genes; gene frequency; planting;     Show all 6 Subjects
Abstract:
... In a recent study of de novo mutations in arabidopsis (Arabidopsis thaliana), Monroe et al. found a lower mutation frequency inside gene bodies and certain essential genes, shattering the long-standing idea that mutations are entirely random across the genome. Here I highlight the molecular nonrandomness of mutations and the type of gene affected. ...
DOI:
10.1016/j.tplants.2022.03.003

10. The Impact of Fast Radiation on the Phylogeny of Bactrocera Fruit Flies as Revealed by Multiple Evolutionary Models and Mutation Rate-Calibrated Clock

Author:
Federica Valerio; Nicola Zadra; Omar Rota-Stabelli; Lino Ometto
Source:
Insects 2022 v.13 no.7 pp. -
ISSN:
2075-4450
Subject:
mutation rate; spontaneous mutation,   etc   ; data collection; ecology; fossils; fruits; hybridization; phylogeny;     Show all 8 Subjects
Abstract:
... Several true fruit flies (Tephritidae) cause major damage to agriculture worldwide. Among them, species of the genus Bactrocera are extensively studied to understand the traits associated with their invasiveness and ecology. Comparative approaches based on a reliable phylogenetic framework are particularly effective, but several nodes of the Bactrocera phylogeny are still controversial, especially ...
DOI:
10.3390/insects13070603

11. Delivery of Cas9-guided ABE8e into stem cells using poly(l-lysine) polypeptides for correction of the hemophilia-associated FIX missense mutation

Author:
Lijuan Rong; Dandan Chen; Xiangbo Huang; Ling Sun
Source:
Biochemical and biophysical research communications 2022 v.628 pp. 49-56
ISSN:
0006-291X
Subject:
missense mutation; point mutation,   etc   ; coagulation; genes; hemophilia; lysine; mutants; nanocarriers; polypeptides; research;     Show all 10 Subjects
Abstract:
... The coagulation factor 9 gene (FIX) point mutation contributes to most hemophilia B cases, providing ideal gene correction models. Here we identified the frequent mutation G20519A (R226Q) in FIX, which resulted in many severe and moderate hemophilia B patients. This study aimed to investigate the effect of HDR and base editing in correcting FIX mutant. We first constructed HEK293 and liver-derived ...
DOI:
10.1016/j.bbrc.2022.08.076

12. Mutation accumulation in inbreeding populations under evolution of the selfing rate

Author:
Kuangyi Xu
Source:
Journal of evolutionary biology 2022 v.35 no.1 pp. 23-39
ISSN:
1010-061X
Subject:
mutation accumulation; mutation rate,   etc   ; conspecificity; extinction; genomics; outcrossing; risk; selfing; temporal variation;     Show all 9 Subjects
Abstract:
... It is theoretically established that self‐fertilization can facilitate mutation accumulation, thus increasing extinction risk. However, in previous studies, selfing rates are often set as fixed parameters, but in natural systems, evolution of selfing rates and deleterious mutations may mutually affect each other. I carried out simulations to investigate the dynamics of selfing rates and mutation a ...
DOI:
10.1111/jeb.13968

13. Susceptibility reversed: modified plant susceptibility genes for resistance to bacteria

Author:
Eleni Koseoglou; Jan M. van der Wolf; Richard G.F. Visser; Yuling Bai
Source:
Trends in plant science 2022 v.27 no.1 pp. 69-79
ISSN:
1360-1385
Subject:
mutation,   etc   ; mutants; pleiotropy;     Show all 3 Subjects
Abstract:
... Plants have evolved complex defence mechanisms to avoid invasion of potential pathogens. Despite this, adapted pathogens deploy effector proteins to manipulate host susceptibility (S) genes, rendering plant defences ineffective. The identification and mutation of plant S genes exploited by bacterial pathogens are important for the generation of crops with durable and broad-spectrum resistance. App ...
DOI:
10.1016/j.tplants.2021.07.018

14. Recombination and mutation shape variations in the major histocompatibility complex

Author:
Yuying Sun; Fang Yuan; Ling Wang; Dongfa Dai; Zhijian Zhang; Fei Liang; Nan Liu; Juan Long; Xiao Zhao; Yongzhi Xi
Source:
Journal of genetics and genomics 2022 pp. -
ISSN:
1673-8527
Subject:
mutation; mutation rate,   etc   ; Chinese people; genomics; haplotypes; linkage disequilibrium; loci; major histocompatibility complex;     Show all 8 Subjects
Abstract:
... The major histocompatibility complex (MHC) is closely associated with numerous diseases, but its high degree of polymorphism complicates the discovery of disease-associated variants. In principle, recombination and de novo mutations are two critical factors responsible for MHC polymorphisms. However, direct evidence for this hypothesis is lacking. Here, we report the generation of fine-scale MHC r ...
DOI:
10.1016/j.jgg.2022.03.006

15. A Genetic Toxicology Study of the Rapid Detection of Nitrosamine Compounds by the rpsL Gene Mutation Assay

Author:
Xueling Peng; Junshuai Zhang; Qingdai Liu
Source:
Foods 2022 v.11 no.13 pp. -
ISSN:
2304-8158
Subject:
mutation rate; spontaneous mutation,   etc   ; ethidium; genes; genotoxicity; mutagenicity; mutagens; polymerase chain reaction; rapid methods;     Show all 9 Subjects
Abstract:
... In a rpsL gene mutation experiment, the mutagenicity of the nitrosamine compounds N-diethylnitrosamine (NDEA) and N-dipropylnitrosamine (NDPA) was investigated at the cellular level, as well as with PCR (polymerase chain reaction) and RCA (rolling-circle amplification) amplification systems. The experiments were set up with 10 ppm, 100 ppm, and 1000 ppm concentration gradients of NDEA and NDPA, an ...
DOI:
10.3390/foods11131893

16. Mutation Rate Analysis of RM Y-STRs in Deep-Rooted Multi-Generational Punjabi Pedigrees from Pakistan

Author:
Shahid Nazir; Atif Adnan; Rahat Abdul Rehman; Wedad Saeed Al-Qahtani; Abrar B. Alsaleh; Hussam S. Al-Harthi; Fatmah Ahmed Safhi; Reem Almheiri; Reem Lootah; Afra Alreyami; Imran Almarri; Chuan-Chao Wang; Allah Rakha; Sibte Hadi
Source:
Genes 2022 v.13 no.8 pp. -
ISSN:
2073-4425
Subject:
mutation; mutation rate,   etc   ; Y chromosome; haplotypes; human genetics; males; meiosis; microsatellite repeats; pedigree; Pakistan;     Show all 10 Subjects
Abstract:
... Y chromosome short tandem repeat polymorphisms (Y-STRs) are important in many areas of human genetics. Y chromosomal STRs, being normally utilized in the field of forensics, exhibit low haplotype diversity in consanguineous populations and fail to discriminate among male relatives from the same pedigree. Rapidly mutating Y-STRs (RM Y-STRs) have received much attention in the past decade. These 13 ...
DOI:
10.3390/genes13081403

17. A dual identification strategy based on padlock ligation and CRISPR/Cas14a for highly specific detection of BRAF V600E mutation in clinical samples

Author:
Weicheng Shi; Yao Gong; Decai Zhang; Tiantian Yang; Ming Yi; Jingyi Tan; Shijia Ding; Wei Cheng
Source:
Analytical methods 2022 v.14 no.19 pp. 1913-1921
ISSN:
1759-9679
Subject:
mutation,   etc   ; biopsy; ligases; prognosis;     Show all 4 Subjects
Abstract:
... BRAF V600E mutation is a single-nucleotide variation (SNV) that is widely found in various cancers and has been demonstrated to have a strong association with the prognosis and development of some diseases. Thus, we developed a strategy based on rolling circle amplification (RCA) and CRISPR/Cas14a to meet the great need for detecting highly specific BRAF V600E mutation in fine-needle biopsy sample ...
DOI:
10.1039/d2ay00319h

18. Genetic alterations in patients with chronic leucocytosis and persistent thrombocytosis

Author:
Naoki Mori; Mari Ohwashi-Miyazaki; Kentaro Yoshinaga; Toshie Ogasawara; Shoko Marshall; Masayuki Shiseki; Hiroshi Sakura; Junji Tanaka
Source:
Journal of genetics 2022 v.101 no.1 pp. 11
ISSN:
0022-1333
Subject:
mutation,   etc   ; myeloid leukemia; patients;     Show all 3 Subjects
Abstract:
... To elucidate the relevance of genetic alterations, we analysed 17 genes known to be involved in haematological neoplasms in patients with chronic leucocytosis and patients with persistent thrombocytosis. Mutations of the JAK2, SETBP1 and ASXL1 genes were found in 1/13, 1/13, and 2/13 patients with leucocytosis, respectively. Mutations of the JAK2, CALR, SETBP1 and ASXL1 genes were found in 1/5, 1/ ...
DOI:
10.1007/s12041-021-01354-7

19. Toward an evolutionary framework for language variation and change

Author:
Emmanuel D. Ladoukakis; Dimitris Michelioudakis; Elena Anagnostopoulou
Source:
BioEssays 2022 v.44 no.3 pp. e2100216
ISSN:
0265-9247
Subject:
mutation,   etc   ; evolution; research programs;     Show all 3 Subjects
Abstract:
... In this paper, we identify the parallels and the differences between language and life as evolvable systems in pursuit of a framework that will investigate language change from the perspective of a general theory of evolution. Despite the consensus that languages change similarly to species, as reflected in the construction of language trees, the field has mainly applied biological techniques to s ...
DOI:
10.1002/bies.202100216

20. Deficient Rnf43 potentiates hyperactive Kras‐mediated pancreatic preneoplasia initiation and malignant transformation

Author:
Xian Zhou; Zhichao Sun; Mengdi Zhang; Xiaoyu Qu; Shuhui Yang; Lianmei Wang; Yanling Jing; Li Li; Weiwei Deng; Fangming Liu; Jin Di; Jie Chen; Jian Wu; Hongbing Zhang
Source:
Animal models and experimental medicine 2022 v.5 no.1 pp. 61-71
ISSN:
2576-2095
Subject:
gain-of-function mutation; loss-of-function mutation,   etc   ; adenocarcinoma; animals; caregivers; medicine; models; monitoring; surgery;     Show all 9 Subjects
Abstract:
... BACKGROUND: Largely due to incidental detection, asymptomatic pancreatic cystic lesions (PCLs) have become prevalent in recent years. Among them, intraductal papillary mucinous neoplasm (IPMN) infrequently advances to pancreatic ductal adenocarcinoma (PDAC). Conservative surveillance versus surgical intervention is a difficult clinical decision for both caregivers and PCL patients. Because RNF43 l ...
DOI:
10.1002/ame2.12203