PubAg

Main content area

You searched for: Subject "mutation" Remove constraint Subject: "mutation"
Start Over

Search

29,059  Search Results

« Previous | 1 - 20 of 29,059 |
Number of results to display per page

Search Results

1. π-π stacking interaction is a key factor for the stability of GH11 xylanases at low pH

Author:
Ge, Hui-Hua; Qiu, Yue; Yi, Zhi-Wei; Zeng, Run-Ying; Zhang, Guang-Ya
Source:
International journal of biological macromolecules 2019 v.124 pp. 895-902
ISSN:
0141-8130
Subject:
mutation,   etc   ; amino acids; engineering; equations; pH; xylanases;     Show all 6 Subjects
Abstract:
... Acidic xylanases possess the unique features necessary for the tolerance of acidic environments, which may have great potentials for industrial purposes. However, factors controlling the pH-dependent stability of xylanases are only partially known. Here we proposed a residue interaction networks based method to analyze the differences of residue interactions between 6 pairs of experimentally verif ...
DOI:
10.1016/j.ijbiomac.2018.11.282

2. Temporal evolution of Acinetobacter baumannii ST107 clone: conversion of blaOXA-143 into blaOXA-231 coupled with mobilization of ISAba1 upstream occAB1

Author:
Rodrigues-Costa, Fernanda; Cayô, Rodrigo; Matos, Adriana Pereira; Girardello, Raquel; Martins, Willames M.B.S.; Carrara-Marroni, Floristher Elaine; Gales, Ana Cristina
Source:
Research in microbiology 2019 v.170 no.1 pp. 53-59
ISSN:
0923-2508
Subject:
mutation,   etc   ; Acinetobacter baumannii; carbapenems; transcription (genetics);     Show all 4 Subjects
Abstract:
... Nine carbapenem-resistant Acinetobacter baumannii isolates carrying blaOXA-231 and an ISAba1 upstream occAB1 were evaluated. They were clonally related and belonged to ST107. An OXA-143-producing A. baumannii ST107 strain (Ac-148) that did not possess ISAba1 upstream occAB1 was included in the analysis. Reduction in the expression of occAB1 and a 4-fold increase of carbapenem MICs were observed fo ...
DOI:
10.1016/j.resmic.2018.07.001

3. Detecting Rare Mutations and DNA Damage with Sequencing-Based Methods

Author:
Sloan, Daniel B.; Broz, Amanda K.; Sharbrough, Joel; Wu, Zhiqiang
Source:
Trends in biotechnology 2018 v.36 pp. 729-740
ISSN:
0167-7799
Subject:
mutation,   etc   ; DNA damage; tissues;     Show all 3 Subjects
Abstract:
... There is a great need in biomedical and genetic research to detect DNA damage and de novo mutations, but doing so is inherently challenging because of the rarity of these events. The enormous capacity of current DNA sequencing technologies has opened the door for quantifying sequence variants present at low frequencies in vivo, such as within cancerous tissues. However, these sequencing technologi ...
DOI:
10.1016/j.tibtech.2018.02.009

4. Phosphorylation alters Bim‐mediated Mcl‐1 stabilization and priming

Author:
Conage‐Pough, Jason E.; Boise, Lawrence H.
Source:
TheFEBS journal 2018 v.285 no.14 pp. 2626-2640
ISSN:
1742-464X
Subject:
mutation,   etc   ; apoptosis; phosphorylation; proteins;     Show all 4 Subjects
Abstract:
... Mcl‐1 is a highly labile protein, subject to extensive post‐translational regulation. This distinguishes Mcl‐1 from other antiapoptotic proteins and necessitates further study to better understand how interactions with proapoptotic Bcl‐2 proteins affect its regulation. One such protein, Bim, is known to stabilize Mcl‐1, and Bim phosphorylation has been associated with increased Mcl‐1 binding. Cons ...
DOI:
10.1111/febs.14505

5. Interactions between BTB domain of CP190 and two adjacent regions in Su(Hw) are required for the insulator complex formation

Author:
Melnikova, Larisa; Kostyuchenko, Margarita; Molodina, Varvara; Parshikov, Alexander; Georgiev, Pavel; Golovnin, Anton
Source:
Chromosoma 2018 v.127 no.1 pp. 59-71
ISSN:
0009-5915
Subject:
mutation,   etc   ; Drosophila; chromatin; genomics;     Show all 4 Subjects
Abstract:
... The best-studied Drosophila insulator complex consists of two BTB-containing proteins, the Mod(mdg4)-67.2 isoform and CP190, which are recruited cooperatively to chromatin through interactions with the DNA-binding architectural protein Su(Hw). While Mod(mdg4)-67.2 interacts only with Su(Hw), CP190 interacts with many other architectural proteins. In spite of the fact that CP190 is critical for the ...
DOI:
10.1007/s00412-017-0645-6

6. Solving Mendelian Mysteries: The Non-coding Genome May Hold the Key

Author:
Valente, Enza Maria; Bhatia, Kailash P.
Source:
Cell 2018 v.172 pp. 889-891
ISSN:
0092-8674
Subject:
mutation,   etc   ; genes; genomics; transcriptomics;     Show all 4 Subjects
Abstract:
... Despite revolutionary advances in sequencing approaches, many mendelian disorders have remained unexplained. In this issue of Cell, Aneichyk et al. combine genomic and cell-type-specific transcriptomic data to causally link a non-coding mutation in the ubiquitous TAF1 gene to X-linked dystonia-parkinsonism. ...
DOI:
10.1016/j.cell.2018.02.022

7. The effects of cardiomyopathy-associated mutations in the head-to-tail overlap junction of α-tropomyosin on its properties and interaction with actin

Author:
Matyushenko, Alexander M.; Koubassova, Natalia A.; Shchepkin, Daniil V.; Kopylova, Galina V.; Nabiev, Salavat R.; Nikitina, Larisa V.; Bershitsky, Sergey Y.; Levitsky, Dmitrii I.; Tsaturyan, Andrey K.
Source:
International journal of biological macromolecules 2019 v.125 pp. 1266-1274
ISSN:
0141-8130
Subject:
point mutation,   etc   ; actin; cardiomyopathy; muscle contraction; muscles; phenotype; sarcomeres; tropomyosins;     Show all 8 Subjects
Abstract:
... Tropomyosin (Tpm) plays a crucial role in the regulation of muscle contraction by controlling actin-myosin interaction. Tpm coiled-coil molecules bind each other via overlap junctions of their N- and C-termini and form a semi-rigid strand that binds the helical surface of an actin filament. The high bending stiffness of the strand is essential for high cooperativity of muscle regulation. Point mut ...
DOI:
10.1016/j.ijbiomac.2018.09.105

8. Two distinct aggregation pathways in transthyretin misfolding and amyloid formation Proteins and proteomics

Author:
Dasari, Anvesh K.R.; Hung, Ivan; Gan, Zhehong; Lim, Kwang Hun
Source:
Biochimica et biophysica acta 2019 v.1867 no.3 pp. 344-349
ISSN:
1570-9639
Subject:
mutation,   etc   ; amyloid; chemical structure; nuclear magnetic resonance spectroscopy; pH; prealbumin;     Show all 6 Subjects
Abstract:
... Misfolding and amyloid formation of transthyretin (TTR) is implicated in numerous degenerative diseases. TTR misfolding is greatly accelerated under acidic conditions, and thus most of the mechanistic studies of TTR amyloid formation have been conducted at various acidic pH values (2–5). In this study, we report the effect of pH on TTR misfolding pathways and amyloid structures. Our combined solut ...
DOI:
10.1016/j.bbapap.2018.10.013

9. Structural diversity and flexibility of diabodies

Author:
Kwon, Na-Young; Kim, Youngjin; Lee, Jie-Oh
Source:
Methods 2019 v.154 pp. 136-142
ISSN:
1046-2023
Subject:
mutation,   etc   ; antibodies; antigens; binding sites; disulfide bonds; nanotechnology; structural biology;     Show all 7 Subjects
Abstract:
... Diabodies are bispecific antibody fragments that have two antigen binding Fv domains. They are unique among hundreds of different formats of bispecific antibodies because they are small and rigid enough to be crystallized. Diabodies are generated by connecting variable regions of heavy and light chains by a peptide linker. Because of the short length of the linker, intramolecular association of th ...
DOI:
10.1016/j.ymeth.2018.09.005

10. A guide to nucleic acid detection by single-molecule kinetic fingerprinting

Author:
Johnson-Buck, Alexander; Li, Jieming; Tewari, Muneesh; Walter, Nils G.
Source:
Methods 2019 v.153 pp. 3-12
ISSN:
1046-2023
Subject:
mutation,   etc   ; filters; fluorescent dyes; microRNA; monitoring; polymerase chain reaction;     Show all 6 Subjects
Abstract:
... Conventional methods for detecting small quantities of nucleic acids require amplification by the polymerase chain reaction (PCR), which necessitates prior purification and introduces copying errors. While amplification-free methods do not have these shortcomings, they are generally orders of magnitude less sensitive and specific than PCR-based methods. In this review, we provide a practical guide ...
DOI:
10.1016/j.ymeth.2018.08.002

11. Correction to: A statistical framework for analyzing deep mutational scanning data

Author:
Rubin, Alan F.; Gelman, Hannah; Lucas, Nathan; Bajjalieh, Sandra M.; Papenfuss, Anthony T.; Speed, Terence P.; Fowler, Douglas M.
Source:
Genome biology 2018 v.19 no.1 pp. 17
ISSN:
1474-760X
Subject:
mutation,   etc   ; human genetics; models; variance;     Show all 4 Subjects
Abstract:
... CORRECTION: After publication of our article [1] it was brought to our attention that a line of code was missing from our program to combine the within-replicate variance and between-replicate variance. This led to an overestimation of the standard errors calculated using the Enrich2 random-effects model. ...
DOI:
10.1186/s13059-018-1391-7

12. Corneal Dystrophy Mutations Drive Pathogenesis by Targeting TGFBIp Stability and Solubility in a Latent Amyloid-forming Domain

Author:
Stenvang, Marcel; Schafer, Nicholas P.; Malmos, Kirsten Gade; Pérez, Adriana-Michelle Wolf; Niembro, Olatz; Sormanni, Pietro; Basaiawmoit, Rajiv Vaid; Christiansen, Gunna; Andreasen, Maria; Otzen, Daniel E.
Source:
Journal of molecular biology 2018 v.430 pp. 1116-1140
ISSN:
0022-2836
Subject:
mutation,   etc   ; bioinformatics; cornea; pathogenesis; solubility;     Show all 5 Subjects
Abstract:
... Numerous mutations in the corneal protein TGFBIp lead to opaque extracellular deposits and corneal dystrophies (CDs). Here we elucidate the molecular origins underlying TGFBIp's mutation-induced increase in aggregation propensity through comprehensive biophysical and bioinformatic analyses of mutations associated with every major subtype of TGFBIp-linked CDs including lattice corneal dystrophy (LC ...
DOI:
10.1016/j.jmb.2018.03.001

13. Correction to: Inheritance of the narrow leaf mutation in traditional Japanese evergreen azaleas

Author:
Tasaki, Keisuke; Nakatsuka, Akira; Cheon, Kyeong-Seong; Kobayashi, Nobuo
Source:
Euphytica 2018 v.214 no.4 pp. 76
ISSN:
0014-2336
Subject:
mutation,   etc   ; Rhododendron; leaves; plant breeding;     Show all 4 Subjects
Abstract:
... This article has been published with an erroneous version of Table 2. Please find the correct Table 2 in this document. ...
DOI:
10.1007/s10681-018-2130-6

14. Cooperative Interactions of Three Hotspot Heparin Binding Residues Are Critical for Allosteric Activation of Antithrombin by Heparin

Author:
Richard, Benjamin; Swanson, Richard; Izaguirre, Gonzalo; Olson, Steven T.
Source:
Biochemistry 2018 v.57 no.15 pp. 2211-2226
ISSN:
1520-4995
Subject:
mutation,   etc   ; anticoagulants; energy; heparin; sulfates;     Show all 5 Subjects
Abstract:
... Heparin allosterically activates the anticoagulant serpin, antithrombin, by binding through a sequence-specific pentasaccharide and inducing activating conformational changes in the protein. Three basic residues of antithrombin, Lys114, Lys125, and Arg129, have been shown to be hotspots for binding the pentasaccharide, but the molecular basis for such hotspot binding has been unclear. To determine ...
DOI:
10.1021/acs.biochem.8b00216

15. An advanced onlooker-ranking-based adaptive differential evolution to extract the parameters of solar cell models

Author:
Muangkote, Nipotepat; Sunat, Khamron; Chiewchanwattana, Sirapat; Kaiwinit, Sirilak
Source:
Renewable energy 2019 v.134 pp. 1129-1147
ISSN:
0960-1481
Subject:
mutation,   etc   ; algorithms; basins; models; solar cells; solar collectors; solar energy; swarms;     Show all 8 Subjects
Abstract:
... Solar cells are one of the renewable energy sources that have been widely used. The parameters extraction plays an important role in the speed and accuracy of models designed for photovoltaic (PV) solar cells and modules. In recent years, the evolutionary algorithm (EA), swarm intelligence (SI), and other nature-inspired (NI) algorithms have been widely used for the parameters extraction of PV mod ...
DOI:
10.1016/j.renene.2018.09.017

16. Loss of K607 and E877 interaction is a key reason for JAK2 K607N mutation caused acute myeloid leukemia

Author:
Wu, Qing-Yun; Ma, Meng-Meng; Zhang, Sen; Liu, Yang; Cao, Jiang; Yan, Zhi-Ling; Li, Zhen-Yu; Zeng, Ling-Yu; Wang, Xiao-Yun; Li, Feng; Xu, Kai-Lin
Source:
International journal of biological macromolecules 2019 v.124 pp. 1123-1131
ISSN:
0141-8130
Subject:
somatic mutation,   etc   ; myeloid leukemia; non-specific protein-tyrosine kinase; patients; signal transduction;     Show all 5 Subjects
Abstract:
... Oncogenic activation of tyrosine kinase signaling pathway is recurrent in human leukemia. The acquired Janus kinase 2 (JAK2) K607N somatic mutation was detected in about 6.8% of acute myeloid leukemia (AML) patients. However, roles of JAK2 K607N mutation in the leukemogenesis of AML remain unclear. In this study, loss of interaction between K607 and E877 was identified as key reasons for JAK2 K607 ...
DOI:
10.1016/j.ijbiomac.2018.11.280

17. A label-free electrochemical biosensor for microRNAs detection based on DNA nanomaterial by coupling with Y-shaped DNA structure and non-linear hybridization chain reaction

Author:
Zhou, Lin; Wang, Yang; Yang, Cheng; Xu, Huan; Luo, Jie; Zhang, Wenqing; Tang, Xiaoqi; Yang, Sha; Fu, Weiling; Chang, Kai; Chen, Ming
Source:
Biosensors & bioelectronics 2019 v.126 pp. 657-663
ISSN:
0956-5663
Subject:
mutation,   etc   ; DNA; bioassays; biosensors; blood serum; detection limit; electrochemistry; hybridization; hybridization chain reaction; microRNA; nanomaterials;     Show all 11 Subjects
Abstract:
... DNA nanomaterials have been widely used in bioassays due to their promising properties for sensitive and specific detection of biomolecules. Herein, a label-free electrochemical method was developed for quantitative detection of microRNAs by integrating Y-shaped DNA (Y-DNA) structures with non-linear hybridization chain reaction (non-linear HCR). The Y-DNA structures consisting of three sequences ...
DOI:
10.1016/j.bios.2018.11.028

18. Generation of Fabs-in-tandem immunoglobulin molecules for dual-specific targeting

Author:
Gong, Shiyong; Wu, Chengbin
Source:
Methods 2019 v.154 pp. 87-92
ISSN:
1046-2023
Subject:
mutation,   etc   ; immunoglobulins; mammals; manufacturing; mechanism of action; molecular biology; monoclonal antibodies; pharmaceutical industry;     Show all 8 Subjects
Abstract:
... Bispecific antibody (BsAb) has become an important trend in developing next generation biologics therapies. By simultaneously engaging two molecular targets, BsAbs show distinctive mechanism of actions that could lead to clinical benefits unattainable by conventional monoclonal antibodies (mAbs). Successful launch provided clinical validation and encourage more BsAb development in the pipeline of ...
DOI:
10.1016/j.ymeth.2018.07.014

19. New daily global solar irradiation estimation model based on automatic selection of input parameters using evolutionary artificial neural networks

Author:
Marzouq, M.; Bounoua, Z.; El Fadili, Hakim; Mechaqrane, A.; Zenkouar, K.; Lakhliai, Z.
Source:
Journal of cleaner production 2019 v.209 pp. 1105-1118
ISSN:
0959-6526
Subject:
mutation,   etc   ; case studies; evolution; neural networks; planning; population size; regression analysis; solar energy; solar radiation; Morocco;     Show all 10 Subjects
Abstract:
... Assessment of solar potential over a location of interest is introduced as an important step for the successful planning of solar energy systems (photovoltaic or thermal). The aim of this paper is to develop an automatic selection of ANN inputs from available parameters set for the estimation of horizontal daily global solar irradiation in the city of Fez (Morocco). This selection is carried out u ...
DOI:
10.1016/j.jclepro.2018.10.254

20. Rapid, real-time chemiluminescent detection of DNA mutation based on digital microfluidics and pyrosequencing

Author:
Zou, Fenxiang; Ruan, Qingyu; Lin, Xiaoye; Zhang, Mingxia; Song, Yanling; Zhou, Leiji; Zhu, Zhi; Lin, Shuichao; Wang, Wei; Yang, Chaoyong James
Source:
Biosensors & bioelectronics 2019 v.126 pp. 551-557
ISSN:
0956-5663
Subject:
mutation,   etc   ; DNA; automation; bioluminescence; biosensors; genes; genetic testing; microfluidic technology; mutants; sequence analysis; sex determination analysis;     Show all 11 Subjects
Abstract:
... To explore genome mutation meaningfully, it is in urgent need to develop an automated and inexpensive platform for DNA mutation analysis. Digital microfluidics is a powerful platform for a broad range of applications due to the advantages of high automatization and low reagent consumption. Pyrosequencing enables DNA sequencing based on non-electrophoresis bioluminescence, which is suitable for rap ...
DOI:
10.1016/j.bios.2018.09.092