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1. Synthetic production of prenylated naringenins in yeast using promiscuous microbial prenyltransferases

Author:
Isogai, Shota; Okahashi, Nobuyuki; Asama, Ririka; Nakamura, Tomomi; Hasunuma, Tomohisa; Matsuda, Fumio; Ishii, Jun; Kondo, Akihiko
Source:
Metabolic Engineering Communications 2021 v.12 pp. e00169
ISSN:
2214-0301
Subject:
naringenin,   etc   ; biochemical pathways; dimethylallyltranstransferase; genomics; phenylalanine; regioselectivity; synthesis; tryptophan; yeasts;     Show all 9 Subjects
Abstract:
... Reconstitution of prenylflavonoids using the flavonoid biosynthetic pathway and prenyltransferases (PTs) in microbes can be a promising attractive alternative to plant-based production or chemical synthesis. Here, we demonstrate that promiscuous microbial PTs can be a substitute for regiospecific but mostly unidentified botanical PTs. To test the prenylations of naringenin, we constructed a yeast ...
DOI:
10.1016/j.mec.2021.e00169

2. Managing enzyme promiscuity in plant specialized metabolism: A lesson from flavonoid biosynthesis: Mission of a “body double” protein clarified

Author:
Waki, Toshiyuki; Takahashi, Seiji; Nakayama, Toru
Source:
BioEssays 2021 v.43 no.3 pp. e2000164
ISSN:
0265-9247
Subject:
naringenin-chalcone synthase,   etc   ; biosynthesis; catalytic activity; chalcone isomerase; flavonoids;     Show all 5 Subjects
Abstract:
... Specificities of enzymes involved in plant specialized metabolism, including flavonoid biosynthesis, are generally promiscuous. This enzyme promiscuity has served as an evolutionary basis for new enzyme functions and metabolic pathways in land plants adapting to environmental challenges. This phenomenon may lead, however, to inefficiency in specialized metabolism and adversely affect metabolite‐me ...
DOI:
10.1002/bies.202000164

3. Potential application of CHS and 4CL genes from grape endophytic fungus in production of naringenin and resveratrol and the improvement of polyphenol profiles and flavour of wine

Author:
Lu, Yao; Song, Yuyang; Zhu, Jing; Xu, Xiaoguang; Pang, Bing; Jin, Han; Jiang, Chunmei; Liu, Yanlin; Shi, Junling
Source:
Food chemistry 2021 v.347 pp. 128972
ISSN:
0308-8146
Subject:
naringenin; naringenin-chalcone synthase,   etc   ; Alternaria; Saccharomyces cerevisiae; anthocyanins; cheeses; coculture; endophytes; flavonols; flavor; food chemistry; fruits; fungi; grapes; ligases; odors; polyphenols; resveratrol; winemaking; wines;     Show all 20 Subjects
Abstract:
... 4-Coumaroyl-CoA ligase (Al4CL) and chalcone synthase (AlCHS) genes were found in grape endophyte Alternaria sp. MG1, but were not functional verified. A cross-validation method was used in Saccharomyces cerevisiae to identify their functions. AlCHS was identified to synthesize both naringenin and resveratrol, while Al4CL synthesized p-coumaroyl CoA. Co-culture of S. cerevisiae strains separately c ...
DOI:
10.1016/j.foodchem.2020.128972

4. Analysis of secondary metabolites induced by yellowing process for understanding rice yellowing mechanism

Author:
Liu, Yuqian; Liu, Jinguang; Wang, Rui; Sun, Hui; Li, Mei; Strappe, Padraig; Zhou, Zhongkai
Source:
Food chemistry 2021 v.342 pp. 128204
ISSN:
0308-8146
Subject:
naringenin,   etc   ; biomarkers; biosynthesis; chalcone; color; flavonols; food chemistry; metabolomics; rice; secondary metabolites;     Show all 10 Subjects
Abstract:
... The current study applied wide-targeted metabolomics based approach using LC-ESI-MS/MS to characterize the secondary metabolic difference between yellowed and normal rice. The results indicated that the biosynthesis of secondary metabolites including flavonoids, flavonols and phenolic acids was significantly enhanced during the rice yellowing process, which appears to be highly managed by phenylpr ...
DOI:
10.1016/j.foodchem.2020.128204

5. Binding mechanism of naringenin with monoamine oxidase – B enzyme: QM/MM and molecular dynamics perspective

Author:
Govindasamy, Hunday; Magudeeswaran, Sivanandam; Kandasamy, Saravanan; Poomani, Kumaradhas
Source:
Heliyon 2021 v.7 no.4 pp. e06684
ISSN:
2405-8440
Subject:
naringenin,   etc   ; Parkinson disease; amine oxidase (flavin-containing); brain; dopamine; molecular dynamics; oxidation;     Show all 7 Subjects
Abstract:
... The reduced level of dopamine at midbrain (substantia nigra) leads to Parkinson disease by the influence of monoamine oxidation process of monoamine oxidase B (MAO-B) enzyme. This disease mostly affects the aged people. Reports outline that the naringenin molecule acts as an inhibitor of MAO-B enzyme and it potentially prevents the development of PD. To elucidate the binding mechanism of naringeni ...
DOI:
10.1016/j.heliyon.2021.e06684

6. Biologically guided isolation and ADMET profile of new factor Xa inhibitors from Glycyrrhiza glabra roots using in vitro and in silico approaches

Author:
Ibrahim, Reham S.; Mahrous, Rahma S. R.; Abu EL-Khair, Rasha M.; Ross, Samir A.; Omar, Abdallah A.; Fathy, Hoda M.
Source:
RSC advances 2021 v.11 no.17 pp. 9995-10001
ISSN:
2046-2069
Subject:
naringenin,   etc   ; COVID-19 infection; Glycyrrhiza glabra; coagulation; computer simulation; formononetin; licorice; root extracts; therapeutics;     Show all 9 Subjects
Abstract:
... Selective factor Xa inhibitors effectively block coagulation cascade with a broader therapeutic window than multitargeted anticoagulants. They have evolved as a crucial part of prevention and treatment of thromboembolic diseases and in therapeutic protocols involved in many clinical trials in coronavirus disease 2019 (COVID-19) patients. Biologically-guided isolation of specific FXa inhibitors fro ...
DOI:
10.1039/d1ra00359c

7. Six flavonoids inhibit the antigenicity of β-lactoglobulin by noncovalent interactions: A spectroscopic and molecular docking study

Author:
Pu, Pei; Zheng, Xin; Jiao, Linna; Chen, Lang; Yang, Han; Zhang, Yonghong; Liang, Guizhao
Source:
Food chemistry 2021 v.339 pp. 128106
ISSN:
0308-8146
Subject:
naringenin,   etc   ; allergenicity; decline; epigallocatechin gallate; epitopes; food chemistry; kaempferol; myricetin; quercetin; spectroscopy;     Show all 10 Subjects
Abstract:
... It is practical to inhibit the allergenicity of β-lactoglobulin (β-LG) using natural products acting via noncovalent interactions; however, the mechanism of the effect has not been investigated in detail. Herein, the comprehensive noncovalent mechanism of inhibition of the antigenicity of β-LG by six flavonoids (kaempferol, myricetin, phloretin, epigallocatechin-3-gallate (EGCG), naringenin, and q ...
DOI:
10.1016/j.foodchem.2020.128106

8. Retinal Neurodegeneration: Correlation between Nutraceutical Treatment and Animal Model

Author:
Piano, Ilaria; Di Paolo, Mattia; Corsi, Francesca; Piragine, Eugenia; Bisti, Silvia; Gargini, Claudia; Di Marco, Stefano
Source:
Nutrients 2021 v.13 no.3
ISSN:
2072-6643
Subject:
naringenin,   etc   ; animal models; blindness; dietary supplements; gene therapy; genes; humans; neurodegenerative diseases; saffron;     Show all 9 Subjects
Abstract:
... Retinal diseases can be induced by a variety of factors, including gene mutations, environmental stresses and dysmetabolic processes. The result is a progressive deterioration of visual function, which sometimes leads to blindness. Many treatments are under investigation, though results are still mostly unsatisfactory and restricted to specific pathologies, particularly in the case of gene therapy ...
DOI:
10.3390/nu13030770

9. Effects of metabolic pathway gene copy numbers on the biosynthesis of (2S)-naringenin in Saccharomyces cerevisiae

Author:
Li, Hongbiao; Gao, Song; Zhang, Siqi; Zeng, Weizhu; Zhou, Jingwen
Source:
Journal of biotechnology 2021 v.325 pp. 119-127
ISSN:
0168-1656
Subject:
naringenin,   etc   ; Saccharomyces cerevisiae; biochemical pathways; biosynthesis; biotechnology; p-coumaric acid; tyrosine;     Show all 7 Subjects
Abstract:
... Flavonoids have notable biological activities and have been widely used in the medicinal and chemical industries. However, single-copy integration of heterologous pathway genes limits the production of flavonoids. In this work, we designed and constructed single-step integration of multiple flavonoid (2S)-naringenin biosynthetic pathway genes in S. cerevisiae. The efficiency of the naringenin meta ...
DOI:
10.1016/j.jbiotec.2020.11.009

10. Assessing the effect and related mechanism of naringenin on the proliferation, osteogenic differentiation and endothelial differentiation of human periodontal ligament stem cells

Author:
Zhang, Li; He, Haiyan; Zhang, Min; Wu, Yujie; Xu, Xiaomei; Yang, Maohua; Mei, Li
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 337-342
ISSN:
0006-291X
Subject:
naringenin,   etc   ; antagonists; bioactive properties; bone formation; gene expression; humans; ligaments; research;     Show all 8 Subjects
Abstract:
... Naringenin (NAR) is a natural flavonoid which exerts extensive biological activity, including anti-oxidation, anti-inflammation, anti-cancer, immune regulation and so on. However, the effect and mechanism of NAR in the alveolar bone regeneration are still unclear, which limits its clinical use. Hence, we investigated the effects of NAR in the proliferation, osteogenic and endothelial differentiati ...
DOI:
10.1016/j.bbrc.2020.11.081

11. GABA mediates NO/cGMP/GSK-3-induced isoflavone accumulation in soybean sprouts

Author:
Jiao, Caifeng; Liu, Yongsheng
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2021 v.135 pp. 110027
ISSN:
0023-6438
Subject:
naringenin-chalcone synthase,   etc   ; ; biosynthesis; diamine oxidase; genes; glycogen (starch) synthase; isoflavones; nitric oxide; protein synthesis; soybeans;     Show all 10 Subjects
Abstract:
... The effects of glycogen synthase kinase-3 (GSK-3) on nitric oxide (NO)/guanosine 3′,5′-cyclic monophosphate (cGMP)-activated γ-aminobutiric acid (GABA) accumulation and the role of GABA in isoflavone biosynthesis in response to UV-B exposure in soybean sprouts were investigated. The sprouts were sprayed using donors and inhibitors of cGMP and NO as well as inhibitors of GSK-3 and GABA. It turned o ...
DOI:
10.1016/j.lwt.2020.110027

12. Assessment of in-vitro bioaccessibility and antioxidant capacity of phenolic compounds extracts recovered from grapevine bunch stem and cane by-products

Author:
Ferreyra, Susana; Torres-Palazzolo, Carolina; Bottini, Rubén; Camargo, Alejandra; Fontana, Ariel
Source:
Food chemistry 2021 v.348 pp. 129063
ISSN:
0308-8146
Subject:
naringenin,   etc   ; Vitis; antioxidant activity; bioavailability; cinnamic acid; cultivars; dietary supplements; food chemistry; grapes; in vitro digestion; intestines; myricetin; syringic acid;     Show all 13 Subjects
Abstract:
... Grapevine woody by-products contain bioactive substances, mainly phenolic compounds (PCs), whose beneficial health effects initially depends on their levels of intake and bioavailability. Therefore, in-vitro simulated gastrointestinal digestion (GID; oral, gastric and intestinal phases) was performed to evaluate the bioaccessibility and antioxidant capacity (AC) of PCs extracts recovered from grap ...
DOI:
10.1016/j.foodchem.2021.129063

13. Comparison of physical, microstructural and antioxidative properties of pumpkin cubes cooked by conventional, vacuum cooking and sous vide methods

Author:
Rinaldi, Massimiliano; Santi, Saverio; Paciulli, Maria; Ganino, Tommaso; Pellegrini, Nicoletta; Visconti, Attilio; Vitaglione, Paola; Barbanti, Davide; Chiavaro, Emma
Source:
Journal of the science of food and agriculture 2021 v.101 no.6 pp. 2534-2541
ISSN:
0022-5142
Subject:
naringenin,   etc   ; agriculture; antioxidant activity; carotenoids; color; food industry; fruits; gallic acid; legumes; microstructure; patents; plasmolysis; polyphenols; pumpkins; steam; texture;     Show all 16 Subjects
Abstract:
... BACKGROUND: Current dietary guidelines recommend five or more fruit, vegetable, and legume servings per day. Often, these products are eaten cooked, resulting in organoleptic and nutritional changes. Vacuum cooking is gaining attention as an alternative cooking technique, due to its ability to preserve or even enhance sensory and healthy properties of food. Its household application is, however, p ...
DOI:
10.1002/jsfa.10880

14. Effects of UV-A radiation on organ-specific accumulation and gene expression of isoflavones and flavonols in soybean sprout

Author:
Lim, You Jin; Lyu, Jae Il; Kwon, Soon-Jae; Eom, Seok Hyun
Source:
Food chemistry 2021 v.339 pp. 128080
ISSN:
0308-8146
Subject:
naringenin,   etc   ; biochemical pathways; daidzein; daidzin; food chemistry; gene expression; genistein; genistin; glycosides; irradiation; kaempferol; soybeans; synthesis; ultraviolet radiation;     Show all 14 Subjects
Abstract:
... Organ-specific flavonoid destination in soybean sprouts following UV irradiation is still unclear although the metabolic pathway of flavonoid synthesis and UV responded flavonoid accumulation have been well investigated. We report the identification of organ-specific localization and specific gene expression of isoflavones and kaempferol glycosides in the soybean sprouts responded to UV-A irradiat ...
DOI:
10.1016/j.foodchem.2020.128080

15. Ultrasound assisted extraction of phytochemicals from Coccinia indica fruits and its characterization

Author:
Sharma, Alok; Mazumdar, Bidyut; Keshav, Amit
Source:
Journal of food measurement & characterization 2021 v.15 no.1 pp. 466-477
ISSN:
2193-4126
Subject:
naringenin,   etc   ; Coccinia grandis; antioxidant activity; apigenin; ethanol; fruits; gallic acid; kaempferol; measurement; response surface methodology; resveratrol; rutin; solvents; temperature; ultrasonics;     Show all 15 Subjects
Abstract:
... Ultrasound assisted extraction (UAE) technique was employed for the extraction of phytochemicals from Coccinia indica fruit. Twenty-two compounds were identified post extraction process by GCMS analysis. Temperature, time of extraction, solvent concentration and solid-solvent (SS) ratio were considered as important process parameters for UAE. Response surface method was applied for optimizing the ...
DOI:
10.1007/s11694-020-00633-8

16. Correction to: Cascade biocatalysis systems for bioactive naringenin glucosides and quercetin rhamnoside production from sucrose

Author:
Thapa, Samir Bahadur; Pandey, Ramesh Prasad; Bashyal, Puspalata; Yamaguchi, Tokutaro; Sohng, Jae Kyung
Source:
Applied microbiology and biotechnology 2019 v.103 no.19 pp. 8281
ISSN:
0175-7598
Subject:
naringenin,   etc   ; biocatalysis; glucosides; quercetin; sucrose;     Show all 5 Subjects
Abstract:
... The name of the author “Yamaguchi Tokutaro” is incorrect for the first and last name has been interchanged. The correct presentation is “Tokutaro Yamaguchi”. ...
DOI:
10.1007/s00253-019-10079-8

17. Enhanced Biosynthesis of Dihydromyricetin in Saccharomyces cerevisiae by Coexpression of Multiple Hydroxylases

Author:
Li, Guangjian; Li, Hongbiao; Lyu, Yunbin; Zeng, Weizhu; Zhou, Jingwen
Source:
Journal of agricultural and food chemistry 2020 v.68 no.48 pp. 14221-14229
ISSN:
1520-5118
Subject:
naringenin,   etc   ; Saccharomyces cerevisiae; bioreactors; biosynthesis; food chemistry; glucose; synergism;     Show all 7 Subjects
Abstract:
... Dihydromyricetin (DHM) is a traditional plant-extracted flavonoid with some health benefits. This study aimed to metabolically engineer the strains for DHM bioproduction. Two strains of BK-11 and BQ-21 were integrated with flavonoid 3-hydroxylase (F3H) or both F3H and flavonoid 3′-hydroxylase (F3′H). The resulting strains have expressed the enzymes of GmCPR and SlF3′5′H, and then, the promoters of ...
DOI:
10.1021/acs.jafc.0c05261

18. Alcoholic fermentation of citrus flavedo and albedo with pure and mixed yeast strains: Physicochemical characteristics and phytochemical profiles

Author:
Multari, Salvatore; Guzzon, Raffele; Caruso, Marco; Licciardello, Concetta; Martens, Stefan
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2021 v.144 pp. 111133
ISSN:
0023-6438
Subject:
naringenin,   etc   ; Citrus limon; Citrus paradisi; Citrus sinensis; Dekkera bruxellensis; Saccharomyces cerevisiae; Torulaspora delbrueckii; alcoholic fermentation; carotenoids; dietary supplements; grapefruits; hesperidin; lemons; oils; yeasts;     Show all 15 Subjects
Abstract:
... The present study aimed to investigate the effects of alcoholic fermentation on the physicochemical and phytochemical characteristics of the tissues flavedo and albedo from five citrus fruits, namely grapefruit (Citrus paradisi), lemon (Citrus limon), and sweet oranges (Citrus sinensis) cvs. ‘Tarocco’, ‘Washington navel’, and ‘Moro’. The tissues were fermented with pure and mixed cultures of Sacch ...
DOI:
10.1016/j.lwt.2021.111133

19. Effects of postharvest irradiation and superfine grinding wall disruption treatment on the bioactive compounds, endogenous enzyme activities, and antioxidant properties of pine (Pinus yunnanensis) pollen during accelerated storage

Author:
Cheng, Yong; Quan, Wei; He, Yujie; Qu, Tao; Wang, Zhaojun; Zeng, Maomao; Qin, Fang; Chen, Jie; He, Zhiyong
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2021 v.144 pp. 111249
ISSN:
0023-6438
Subject:
naringenin,   etc   ; 2,2-diphenyl-1-picrylhydrazyl; Pinus yunnanensis; antioxidant activity; antioxidants; ascorbic acid; irradiation; malondialdehyde; metabolism; p-coumaric acid; pine pollen; superoxide dismutase; taxifolin;     Show all 13 Subjects
Abstract:
... Effects of irradiation and superfine grinding wall disruption treatment on quality parameters and antioxidant activity of pine pollen during storage at 55 °C for 8 weeks were investigated. Results showed that irradiation slowed the reduction of taxifolin and ascorbic acid levels and the increase of ferric-ion reducing antioxidant power (FRAP), but accelerated the increase of 1,1-diphenyl-2-picrylh ...
DOI:
10.1016/j.lwt.2021.111249

20. Evaluation of bioactive compounds, phytochemicals profile and antioxidant potential of the aqueous and ethanolic extracts of some traditional fruit tree leaves used in Brazilian folk medicine

Author:
Andrade, Julianna Karla Santana; Barros, Romy Gleyse Chagas; Rezende, Yara Rafaella Ribeiro Santos; Nogueira, Juliete Pedreira; de Oliveira, Christean Santos; Gualberto, Nayjara Carvalho; Narain, Narendra
Source:
Food research international 2021 v.143 pp. 110282
ISSN:
0963-9969
Subject:
naringenin,   etc   ; antioxidant activity; antioxidants; catechin; dietary supplements; epicatechin; food research; fruit trees; fruits; insulin; kaempferol; passion fruits; polyphenols; rutin; soursops; traditional medicine; vanillin; Brazil;     Show all 18 Subjects
Abstract:
... The aim of this study was to analyze eight selected species of leaves, used in the traditional medicine of the Northeast region of Brazil obtained from several fruit trees (grageru, soursop, jambolanum, passion fruit, insulin, nogueira, pedra ume kaá and stévia), regarding their polyphenols contents and antioxidant activity. Condensed and hydrolysable tannins, phenolics and flavonoids contents wer ...
DOI:
10.1016/j.foodres.2021.110282