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necrosis, etc ; antibodies; collagen; environmental exposure; epithelium; fibroblasts; fibrosis; gelatinase A; glycoproteins; inflammation; interleukin-11; interleukin-6; lungs; mice; mitogen-activated protein kinase; neoplasms; neutralization; silica; therapeutics; China; Show all 20 Subjects
Abstract:
... Environmental exposure to crystalline silica particles can lead to silicosis, which is one of the most serious pulmonary interstitial fibrosis around the world. Unfortunately, the exact mechanism on silicosis is unclear, and the effective treatments are lacking to date. In this study, we aim to explore the molecular mechanism by which interleukin-11 (IL-11) affects silica particles-induced lung in ...
... BACKGROUND: Triple‐phase CT and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA) MRI have been used to differentiate hepatocellular carcinomas (HCCs) in dogs. METHODS: This retrospective case series aimed to compare the CT findings with MRI findings of 20 canine hepatocellular lesions, including eight poorly/moderately‐differentiated HCCs, eight well‐differentiated HCCs an ...
... Necrosis is an important biomarker, which only occurs in pathological situations. Tracking of necrosis avid agents is of crucial importance toward understanding their mechanisms. Herein, we developed a modular probe strategy based on bioorthogonal copper-free click chemistry. Structural modification of rhein with transcyclooctene (TCO) led to the identification of rhein-TCO2 as the most active pro ...
necrosis, etc ; algae; marine pollution; microhabitats; Indonesia; Show all 5 Subjects
Abstract:
... This is a comprehensive study showing the marine anthropogenic litter pollution within North Sulawesi, Indonesia. From an area of 2972 m² that encompassed five sparsely populated locations, a total of 9421 litter items weighing 137 kg were collected. One location (Talisei North) contributed 50% of all collected litter items. Plastic litter always dominated with 96–99%. Litter was unevenly distribu ...
Mizael Machado; Cintia R.R. Queiroz; Tais M. Wilson; Davi E.R. Sousa; Benito Soto-Blanco; Aníbal G. Armién; Severo S. Barros; Franklin Riet-Correa; Márcio B. Castro
necrosis, etc ; Ricinus communis; gastroenteritis; hepatocytes; liver; toxicity testing; Show all 6 Subjects
Abstract:
... An outbreak of Ricinus communis poisoning in goats with neurological and digestive changes was related to the ingestion of different vegetative parts of the plant. Two poisoned animals died within 5 h of the plant intake showing necrotic gastroenteritis and hepatocytes degeneration and necrosis. Toxicological analysis by HPLC-DAD assay demonstrated 21.1–25.1 μg/g of ricinine in samples of ruminal ...
Hala Chaaban; Maulin M. Patel; Kathryn Burge; Jeffrey V. Eckert; Cristina Lupu; Ravi S. Keshari; Robert Silasi; Girija Regmi; MaJoi Trammell; David Dyer; Steven J. McElroy; Florea Lupu
necrosis, etc ; antibiotics; cell proliferation; enterocolitis; inflammation; intestines; mortality; therapeutics; Show all 8 Subjects
Abstract:
... Increasing evidence suggests that prolonged antibiotic therapy in preterm infants is associated with increased mortality and morbidities, such as necrotizing enterocolitis (NEC), a devastating gastrointestinal pathology characterized by intestinal inflammation and necrosis. While a clinical correlation exists between antibiotic use and the development of NEC, the potential causality of antibiotics ...
necrosis, etc ; cats; cornea; eyelids; hyaluronic acid; keratitis; ophthalmology; tissues; Show all 8 Subjects
Abstract:
... OBJECTIVE: To describe a technique to repair feline eyelid agenesis using a hyaluronic acid (HA) subdermal filler injection to allow for acute soft tissue expansion, followed by a free labial mucocutaneous graft. MATERIALS AND METHODS: Thirty‐nine colobomatous eyelids in 24 feline patients with secondary keratitis were recruited to the study group. RESULTS: Keratitis and trichiasis were markedly r ...
necrosis; tumor necrosis factor-alpha, etc ; DNA damage; chlorides; earthworms; ecosystems; epithelium; histopathology; muscles; nickel; oxidative stress; polluted soils; protective effect; reactive oxygen species; research; toxicity; Show all 16 Subjects
Abstract:
... In recent years, studies investigating the protective effect of hydrogen-rich water (HRW) against different diseases and the toxicity of some substances have attracted increasing attention. Here, we assessed the effects of hydrogen-rich water on different nickel-induced toxic responses (reactive oxygen species (ROS), tumor necrosis factor-alpha (TNF-α), and 8-hydroxy-2′-deoxyguanosine (8-OHdG) of ...
necrosis, etc ; Eriocheir sinensis; aquaculture; crustin; genes; innate immunity; intestines; starvation; whey; Show all 9 Subjects
Abstract:
... The occurrence of hepatopancreatic necrosis disease (HPND) puts pressure on the healthy aquaculture and development of Chinese mitten crab, Eriocheir sinensis. Research on the mechanism of innate immunity regulation in crabs with HPND is limited. We studied the effects of HPND on the expression of Toll receptor and crustin gene, as well as the relationship between Toll and the synthesis of crustin ...
necrosis, etc ; green fluorescent protein; half life; human serum albumin; ligands; neoplasms; pH; therapeutics; Show all 8 Subjects
Abstract:
... A short in vivo half-life of protein-based therapeutics often restricts successful clinical translation despite their promising efficacy in vitro. As a biocompatible half-life extender, human serum albumin (HSA) has proven effective in some cases. While genetic fusion is well-established for interlinking HSA and a protein payload, it is limited to structurally simple proteins, necessitating new st ...
necrosis, etc ; abscess; cold; dogs; equipment; ferrets; males; medicine; morbidity; pulp; sodium hypochlorite; therapeutics; Show all 12 Subjects
Abstract:
... Root canal therapy has decreased morbidity compared to extraction, but it is underutilised in the first opinion practice due to assumed skill and knowledge requirements. Fractures of ferret (Mustela putorius furo) canines are common due to their anatomy and function. Penetration of bacteria into exposed pulp tissue leads to pain, inflammation, pulp necrosis, abscess and swelling. Therefore, tooth ...
necrosis, etc ; Bromus riparius; Poa pratensis; abiotic stress; cold season; fungi; insects; leaves; mycelium; Show all 9 Subjects
Abstract:
... Silvertop (sterile heads) of perennial cool-season grasses is common in aging stands grown for seed production. It is associated with yield reduction, but the causal agent(s) has not been determined. A study was conducted to examine the cytology of grass tillers with and without silvertop. A series of cross sections of stems from field samples of Kentucky bluegrass and meadow bromegrass (where sig ...
necrosis, etc ; Crassostrea brasiliana; Neotropics; biocides; biomarkers; epithelium; histology; histopathology; marine pollution; oxidative stress; oysters; Show all 11 Subjects
Abstract:
... This study investigated the sublethal effects of environmentally relevant concentrations of DCOIT on the neotropical oyster Crassostrea brasiliana. Gills and digestive glands of animals exposed to increasing concentrations of DCOIT were analyzed for biochemical, cellular, and histopathological responses. Exposure to DCOIT (0.2 to 151 μg L⁻¹) for 120 h triggered oxidative stress in both tissues (th ...
Diego Alves da Silva; Cristiane Lemes Hamawaki; Breno Cezar Marinho Juliatti; Lucas dos Santos Nascimento; Osvaldo Toshiyuki Hamawaki; Díbio Leandro Borges; Fernando Cezar Juliatti; Ana Paula Oliveira Nogueira
necrosis, etc ; Phakopsora pachyrhizi; agriculture; algorithms; chlorosis; cultivars; databases; electronics; farms; soybean rust; soybeans; Brazil; Show all 12 Subjects
Abstract:
... The development of soybean cultivars resistant to Phakopsora pachyrhizi (also known as Asian Soybean Rust (ASR)) may be achieved through genetic breeding. In the stage of selecting the resistant genotypes, one factor that can be used is to observe visually the severity of the rust symptoms upon leaflets of sampled soybean plants. By being able to quantify the exact amounts of regions with chlorosi ...
necrosis, etc ; Echinacea purpurea; biosynthesis; blood serum; hepatoma; histology; metabolites; metabolomics; mice; phenylalanine; tryptophan; tyrosine; Show all 12 Subjects
Abstract:
... Echinacea purpurea (L.) Moench (EP), a well-known “immunostimulant” in the West, is one of the most popular botanicals for patients with cancer. It has been proved to be effective against hepatocellular carcinoma (HCC), while the active ingredients remains unclear. This study aimed to investigate the inhibitory effect and interpret the material basis of EP against HCC through metabolomics and mole ...
K. Forster; L. S. Cutando; J. Ladlow; D. Anderson; C. Burton; S. Das; S. Gibson; N. Kulendra; T. Emmerson; S. Baines; L. Rutherford; R. D. Paulino; R. Fontanini; K. Compagnone; B. De La Puerta
necrosis, etc ; anesthesia; dehiscence; descriptive studies; edema; etiology; hypotension; hypothermia; neoplasms; small animal practice; surgery; Show all 11 Subjects
Abstract:
... OBJECTIVES: To describe the outcome and complications associated with the use of caudal superficial epigastric axial pattern flaps in dogs and cats. MATERIAL AND METHODS: Multicentre retrospective review and descriptive study of clinical records of dogs and cats having undergone caudal superficial epigastric axial pattern flaps between 2007 and 2020. Data retrieved included signalment, aetiology o ...
necrosis, etc ; Terminalia bellirica; cytotoxicity; glucosides; humans; ligands; methanol; neoplasm cells; neoplasms; spectral analysis; Bangladesh; Show all 11 Subjects
Abstract:
... Two new compounds, thannilignan 9-O-β-glucoside (1) and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative (2), and seven known compounds were isolated from the methanol extract of Terminalia bellirica leaves, collected in Bangladesh. The structures of the compounds were elucidated using spectroscopic analysis. Among these isolated compounds, corilagin (3) was cytotoxic against human gastric adeno ...
necrosis, etc ; dogs; epithelium; excision; histology; histopathology; mediastinum; metastasis; mitosis; myasthenia gravis; neoplasms; survival rate; Show all 12 Subjects
Abstract:
... Canine thymic epithelial tumours (TET) are uncommon and little is known about their behaviour. Previous attempts at histologic classification have varied, and as such reliable prognostic information is unavailable. The aim of this retrospective multi‐institutional study was to evaluate cases of canine TETs, irrespective of subtype, in order to identify useful histopathologic and clinicopathologic ...
necrosis, etc ; alcohol drinking; antioxidants; apoptosis; ascorbic acid; diet; ethanol; liver; liver diseases; neutrophils; therapeutics; Show all 11 Subjects
Abstract:
... Alcoholic liver disease (ALD) comprises an important component in chronic liver diseases, and its clinical significance has increased due to the high consumption of alcohol worldwide. Vitamin C is a potent antioxidant, and several previous studies have suggested that its therapeutic role in ALD is derived from its antioxidant role. However, its anti-inflammatory role in ALD remains to be elucidate ...
necrosis, etc ; blood vessels; endothelium; inflammation; mitogen-activated protein kinase; neoplasms; permeability; therapeutics; tight junctions; Show all 9 Subjects
Abstract:
... The endothelium is a monolayer of cells which line all of the vasculature where it acts as a barrier to control permeability of water and other molecules out of a blood vessel. Loss of endothelial barrier function resulting in increased endothelial permeability is often seen in pathological inflammation leading to organ damage. The inflammatory cytokine TNF-α activates several different signaling ...