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1. Electrochemical immunosensors for the detection of cytokine tumor necrosis factor alpha: A review

Author:
Filik, Hayati; Avan, Asiye Aslıhan
Source:
Talanta 2020 v.211 pp. 120758
ISSN:
0039-9140
Subject:
tumor necrosis factor-alpha,   etc   ; electrochemistry; immunosensors; nanomaterials;     Show all 4 Subjects
Abstract:
... In this review, we focus on recent developments in nonlabeled@label-free and labeled@sandwich assay concepts of tumor necrosis factor-alpha (TNF-α) using numerous electrochemical approaches. The fundamental role of such nanostructured materials for the improvement of the analytical response and thus the analytical figures of merit of various TNF-α sensing operations were revealed. Also, this exami ...
DOI:
10.1016/j.talanta.2020.120758

2. Pathological Features of Complete Atrioventricular Block in Dogs with Lymphocytic Myocarditis

Author:
Sasaki, T.; Saeki, C.; Hirakawa, A.; Machida, N.
Source:
Journal of comparative pathology 2020 v.174 pp. 18-25
ISSN:
0021-9975
Subject:
necrosis,   etc   ; cardiomyocytes; dogs; etiology; fibrosis; histology; myocarditis;     Show all 7 Subjects
Abstract:
... The cardiac conduction system was examined histologically in 12 canine cases of lymphocytic myocarditis with complete atrioventricular (AV) block. Histological analysis showed active myocarditis characterized by intense infiltration of mononuclear cells, primarily lymphoid, associated with degeneration and necrosis of the adjacent cardiomyocytes. Additionally, there was healing or healed myocardit ...
DOI:
10.1016/j.jcpa.2019.10.191

3. TNF-α polymorphisms might influence predisposition to periodontitis: A meta-analysis

Author:
Li, Ying; Yang, Jie; Wu, Xiaoyan; Sun, Weifeng
Source:
Microbial pathogenesis 2020 v.143 pp. 104113
ISSN:
0882-4010
Subject:
tumor necrosis factor-alpha,   etc   ; Asians; meta-analysis; patients; periodontitis;     Show all 5 Subjects
Abstract:
... Tumor necrosis factor-α (TNF-α) polymorphisms might influence predisposition to periodontitis, but the results of already published studies were still controversial and ambiguous. So the authors designed this meta-analysis to more precisely estimate relationship between TNF-α polymorphisms and periodontitis by pooling the results of already published related studies.The authors searched Pubmed, Em ...
DOI:
10.1016/j.micpath.2020.104113

4. A computational model for understanding the oligomerization mechanisms of TNF receptor superfamily

Author:
Su, Zhaoqian; Wu, Yinghao
Source:
Computational and Structural Biotechnology Journal 2020 v.18 pp. 258-270
ISSN:
2001-0370
Subject:
tumor necrosis factor receptors; tumor necrosis factors,   etc   ; apoptosis; bioinformatics; cellular microenvironment; cytoplasm; inflammation; ligands; models; oligomerization; signal transduction;     Show all 11 Subjects
Abstract:
... By recognizing members in the tumor necrosis factor (TNF) receptor superfamily, TNF ligand proteins function as extracellular cytokines to activate various signaling pathways involved in inflammation, proliferation, and apoptosis. Most ligands in TNF superfamily are trimeric and can simultaneously bind to three receptors on cell surfaces. It has been experimentally observed that the formation of t ...
DOI:
10.1016/j.csbj.2019.12.016
PubMed:
32021664
PubMed Central:
PMC6994755

5. Zein hydrolysate and its peptides exert anti-inflammatory activity on endothelial cells by preventing TNF-α-induced NF-κB activation

Author:
Liang, Qiufang; Chalamaiah, Meram; Liao, Wang; Ren, Xiaofeng; Ma, Haile; Wu, Jianping
Source:
Journal of functional foods 2020 v.64 pp. 103598
ISSN:
1756-4646
Subject:
necrosis; tumor necrosis factor receptors; tumor necrosis factor-alpha,   etc   ; adhesion; anti-inflammatory activity; cardiovascular diseases; cell adhesion; endothelial cells; hydrolysates; inflammation; intercellular adhesion molecule-1; monocytes; neoplasms; oxidative stress; phosphorylation; transcription factor NF-kappa B; vascular cell adhesion molecules; zein;     Show all 18 Subjects
Abstract:
... Vascular inflammation and oxidative stress are the major causes of endothelial dysfunction leading to cardiovascular disease. Previously, we have reported the anti-inflammatory activity of zein hydrolysate and its-derived peptides. However, the underlying mechanisms have not been understood. In this study, we report that zein hydrolysate and its derived peptides can inhibit the tumor necrosis fact ...
DOI:
10.1016/j.jff.2019.103598

6. Bilobalide alleviates tumor necrosis factor‐alpha‐induced pancreatic beta‐cell MIN6 apoptosis and dysfunction through upregulation of miR‐153

Author:
Hao, Yan; Wang, Weiwei; Wu, Dong; Liu, Kai; Sun, Yihan
Source:
Phytotherapy research 2020 v.34 no.2 pp. 409-417
ISSN:
0951-418X
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; Western blotting; apoptosis; flow cytometry; inducible nitric oxide synthase; insulin secretion; insulin-dependent diabetes mellitus; islets of Langerhans; neoplasms; protein kinases; rapamycin; viability;     Show all 13 Subjects
Abstract:
... Type 1 diabetes mellitus (T1DM) is a systemic disease and one classical type of total DM. Bilobalide (BB) is constituted of EGb 761. Our purpose was identifying the role of BB in TIDM in the current study. MIN6 cells were treated by TNF‐α; then, viability, apoptosis, and insulin secretion were assessed by performing Cell Counting Kit‐8 assay, flow cytometry, glucose‐stimulated insulin secretion as ...
DOI:
10.1002/ptr.6533

7. IFNγ potentiates TNFα/TNFR1 signaling to induce FAT10 expression in macrophages

Author:
Kandel-Kfir, Michal; Garcia-Milan, Rolando; Gueta, Itai; Lubitz, Irit; Ben-Zvi, Ilan; Shaish, Aviv; Shir, Lidar; Harats, Dror; Mahajan, Milind; Canaan, Allon; Kamari, Yehuda
Source:
Molecular immunology 2020 v.117 pp. 101-109
ISSN:
0161-5890
Subject:
tumor necrosis factor receptors; tumor necrosis factor-alpha,   etc   ; gene expression; inflammation; innate immunity; interferons; lipopolysaccharides; macrophage activation; macrophages; pathogens; signal transduction; transcription (genetics); transcription factor NF-kappa B;     Show all 13 Subjects
Abstract:
... The tight regulation of the cytokine network during macrophage activation is of prime importance to enable a fast and potent innate immune response against exogenous pathogens. The inflammation mediating ubiquitin-like protein HLA-F adjacent transcript number 10 (FAT10) was shown to be transcriptionally regulated by and also regulate the nuclear factor-κB (NFκB) signaling pathway. However, very li ...
DOI:
10.1016/j.molimm.2019.11.004

8. Oncolytic vesicular stomatitis viruses selectively target M2 macrophages

Author:
Polzin, Megan; McCanless, Jessica; Owen, Sylas; Sizemore, Dalton; Lucero, Emily; Fuller, Rebecca; Neufeld, Howard S.; Seals, Darren F.; Ahmed, Maryam
Source:
Virus research 2020 v.284 pp. 197991
ISSN:
0168-1702
Subject:
tumor necrosis factor-alpha,   etc   ; Vesiculovirus; cytopathogenicity; disease susceptibility; macrophages; monocytes; mutants; neoplasms; phenotype; vesicular stomatitis; viruses;     Show all 11 Subjects
Abstract:
... Macrophages have been identified as key players within the tumor microenvironment, with classically (M1) and alternatively (M2) activated macrophages exhibiting anti-tumoral and pro-tumoral functions, respectively. The goal of this study was to determine the response of macrophage populations to infection with oncolytic vesicular stomatitis virus (VSV). THP-1 monocytes were differentiated into var ...
DOI:
10.1016/j.virusres.2020.197991

9. Role of NGF on sperm traits: A review

Author:
Castellini, Cesare; Mattioli, Simona; Dal Bosco, Alessandro; Mancinelli, Alice Cartoni; Rende, Mario; Stabile, Anna Maria; Pistilli, Alessandra
Source:
Theriogenology 2020 v.150 pp. 210-214
ISSN:
0093-691X
Subject:
necrosis,   etc   ; acrosome reaction; apoptosis; epididymis; mammals; nerve growth factor; nervous system; receptors; seminal plasma; spermatozoa;     Show all 10 Subjects
Abstract:
... The nerve growth factor (NGF), a member of the neurotrophins family, plays an important role in the nervous system but also in the reproductive apparatus and in sperm traits. The aim of this review is to summarize the effect of NGF on sperm functions of mammals. NGF was detected in seminal plasma of many animal species and its receptors, TrkA and p75NTR, are present in both epididymal and ejaculat ...
DOI:
10.1016/j.theriogenology.2020.01.039

10. Plasmid composition and the chpG gene determine the virulence level of Clavibacter capsici natural isolates in pepper

Author:
Hwang, In Sun; Lee, Hyo Min; Oh, Eom‐Ji; Lee, Seungdon; Heu, Sunggi; Oh, Chang‐Sik
Source:
Molecular plant pathology 2020 v.21 no.6 pp. 808-819
ISSN:
1464-6722
Subject:
necrosis,   etc   ; Clavibacter; Gram-positive bacteria; genes; genomics; leaves; loci; pepper; plasmids; serine proteinases; virulence;     Show all 11 Subjects
Abstract:
... The gram‐positive bacterial species Clavibacter capsici causes necrosis and canker in pepper plants. Genomic and functional analyses of C. capsici type strain PF008 have shown that multiple virulence genes exist in its two plasmids. We aimed to identify the key determinants that control the virulence of C. capsici. Pepper leaves inoculated with 54 natural isolates exhibited significant variation i ...
DOI:
10.1111/mpp.12932

11. A dicyanoisophorone-based, near-infrared, lysosome-targeting pH sensor with an extremely large Stokes shift

Author:
Shen, Wei; Wang, Lei; Zhu, Shen; Yu, Shian; Cai, Chunhui; Yi, Wenjun; Zhu, Qing
Source:
Analytical biochemistry 2020 v.596 pp. 113609
ISSN:
0003-2697
Subject:
necrosis,   etc   ; apoptosis; electron transfer; fluorescence; fluorescent dyes; free radicals; lysosomes; near-infrared spectroscopy; pH; piperazine; protonation;     Show all 11 Subjects
Abstract:
... Intracellular pH plays an important role in various biological processes; abnormal pH changes in the intracellular compartment leads to the production of free radicals, the disruption of membrane contractility, inappropriate apoptosis, and necrosis, resulting in serious illness. Although fluorescent probes have widely been used to detect pH levels owing to their high sensitivity and specificity, t ...
DOI:
10.1016/j.ab.2020.113609

12. CT characteristics of primary splenic torsion in eight dogs

Author:
Hughes, Jonathan R.; Johnson, Victoria S.; Genain, Marie‐Aude
Source:
Veterinary radiology & ultrasound 2020 v.61 no.3 pp. 261-268
ISSN:
1058-8183
Subject:
necrosis,   etc   ; databases; dogs; drainage; hemorrhage; histology; ligaments; retrospective studies; spleen; splenic torsion; surgery;     Show all 11 Subjects
Abstract:
... Splenic torsion is a rare potentially life‐threatening condition characterized by rotation of the spleen around the gastrosplenic and phrenosplenic ligaments leading to occlusion of venous drainage and arterial supply. This retrospective study describes the CT characteristics for dogs with surgically confirmed splenic torsion from 2013 to 2018 using the submissions to a large multinational telerad ...
DOI:
10.1111/vru.12844

13. Anoxia Effects in Asphyxiated Green Sea Turtles (Chelonia mydas) Caught in an Artisanal Fishing Net on the Coast of Brazil

Author:
Jerdy, H.; Mastrangelli, A.; Lacerda, P.; Baldassin, P.; Scarelli, A.C.; Werneck, M.R.; Carvalho, E.
Source:
Journal of comparative pathology 2020 v.176 pp. 67-70
ISSN:
0021-9975
Subject:
necrosis,   etc   ; Chelonia mydas; artisanal fishing; asphyxia; coasts; death; fish nets; lungs; Brazil;     Show all 9 Subjects
Abstract:
... Among studies of drowning in green sea turtles (Chelonia mydas), none have associated drowning with injuries of organs other than the lung. We describe the gross and microscopical findings in 23 green sea turtles found dead in a fishing net. Deprived of air, these animals experienced hypoxia and anoxia before dying, which caused congestion, hydropic degeneration and necrosis in several organs. The ...
DOI:
10.1016/j.jcpa.2020.02.002

14. Two-dimensional and contrast-enhanced ultrasound of intestinal ischaemia in cats: four cases

Author:
Linta, Nikolina; Baron Toaldo, Marco; Del Magno, Sara; Pey, Pascaline; Quinci, Manuela; Diana, Alessia
Source:
Journal of feline medicine and surgery 2020 v.22 no.4 pp. 384-390
ISSN:
1532-2750
Subject:
necrosis,   etc   ; arteries; cats; color; enteritis; histopathology; hospitals; ischemia; jejunum; mesentery; necropsy; surgery; ultrasonics; ultrasonography;     Show all 14 Subjects
Abstract:
... The aim of this study was to describe the results of two-dimensional (2D) and contrast-enhancement ultrasound (CEUS) in four cats with intestinal ischaemia. Data were collected from hospital records of all cats that had intestinal ischaemia between January 2012 and August 2018. The inclusion criteria were complete abdominal ultrasound examination, colour flow Doppler and CEUS of lesions, confirmat ...
DOI:
10.1177/1098612X19837332

15. Associations of TNF-Α −308 G>A and TNF-Β 252 A>G with Physical Function and BNP—Rugao Longevity and Ageing Study

Author:
Yao, S.; Zhu, Y. S.; Shi, G. P.; Guo, J. H.; Wang, Z. D.; Chu, X. F.; Jiang, X. Y.; Jin, Li; Wang, Xiao-Feng
Source:
The journal of nutrition, health & aging 2020 v.24 no.3 pp. 358-363
ISSN:
1279-7707
Subject:
tumor necrosis factor-alpha,   etc   ; elderly; genotype; longevity; lymphotoxin; natriuretic peptides; walking;     Show all 7 Subjects
Abstract:
... OBJECTIVES: To explore the associations of TNF-α −308 G>A (rs1800629) and TNF-β 252 A>G (rs909253) with physical function and plasma B-type natriuretic peptide (BNP). METHODS: Data of 1747 community-dwelling elders from the ageing arm of the Rugao Longevity and Ageing Study was used. Physical function was measured by handgrip strength, Timed Up and Go (TUG) test and 5-meter walking test (5MWT). RE ...
DOI:
10.1007/s12603-020-1336-1

16. Complications of peripheral venous catheters: The need to propose an alternative route of administration

Author:
Mailhe, Morgane; Aubry, Camille; Brouqui, Philippe; Michelet, Pierre; Raoult, Didier; Parola, Philippe; Lagier, Jean-Christophe
Source:
International journal of antimicrobial agents 2020 v.55 no.3 pp. 105875
ISSN:
0924-8579
Subject:
necrosis,   etc   ; antibiotics; arthritis; catheters; hospitals; infectious diseases; intravenous injection; lymphangitis; patients; phlebitis; thrombosis;     Show all 11 Subjects
Abstract:
... Use of peripheral venous catheters (PVCs) is very common in hospitals. According to the literature, after a visit to the emergency department >75% of hospitalised patients carry a PVC, among which almost 50% are useless. In this study, the presence and complications of PVCs in an infectious diseases (ID) unit of a French tertiary-care university hospital were monitored. A total of 614 patients wer ...
DOI:
10.1016/j.ijantimicag.2020.105875

17. Differential characterization of hepatic tumors in MR imaging by burst-released Mn2+-ions from hollow manganese-silicate nanoparticles in the liver

Author:
Kim, Jin Goo; Jang, Moon-Sun; Kumari, Nitee; Choi, Jung Kyu; Im, Geun Ho; Kwon, Taewan; Lee, Jung Hee; Lee, Won Jae; Lee, In Su
Source:
Biomaterials 2020 v.230 pp. 119600
ISSN:
0142-9612
Subject:
necrosis,   etc   ; adenocarcinoma; bioimaging; hepatoma; immunohistochemistry; liver; manganese; mitochondria; nanoparticles; silicates; therapeutics; toxicity;     Show all 12 Subjects
Abstract:
... Gd3+-based contrast agents monopolize in the clinical MR imaging-based diagnosis of hepatic tumors, however, the inherent toxicity by the released Gd3+-ions triggered an urgent demand for safer alternatives. Here, we demonstrate hollow manganese silicate nanoparticles (HMS), which exert burst-release of Mn2+-ions by switching to physiological acidic condition, exhibiting high effectiveness in hepa ...
DOI:
10.1016/j.biomaterials.2019.119600

18. Lip‐to‐nose flap for reconstruction of the nasal planum after curative intent excision of squamous cell carcinoma in cats: Description of technique and outcome in seven cases

Author:
Massari, Federico; Chiti, Lavinia E.; Lisi, Marta L. P.; Drudi, Dario; Montinaro, Vincenzo; Sommaruga, Paolo
Source:
Veterinary surgery 2020 v.49 no.2 pp. 339-346
ISSN:
0161-3499
Subject:
necrosis,   etc   ; aesthetics; cat diseases; cats; edema; excision; nose; squamous cell carcinoma;     Show all 8 Subjects
Abstract:
... OBJECTIVE: To describe the surgical technique for nasal planum reconstruction with a lip‐to‐nose flap after curative intent surgical excision of squamous cell carcinoma (SCC) in cats and to report the surgical outcomes. STUDY DESIGN: Short case series. ANIMALS: Seven cats with SCC of the lateral (n = 6) or dorsal (n = 1) aspect of the nasal planum. METHODS: After tumor excision, a mucocutaneous li ...
DOI:
10.1111/vsu.13359

19. US-triggered ultra-sensitive “thrombus constructor” for precise tumor therapy

Author:
Shao, Yanjiang; Guo, Li; Li, Airong; Zhang, Kaixiang; Liu, Wei; Shi, Jinjin; Liu, Junjie; Zhang, Zhenzhong
Source:
Journal of controlled release 2020 v.318 pp. 136-144
ISSN:
0168-3659
Subject:
necrosis,   etc   ; angiogenesis; apoptosis; blood vessels; cancer therapy; nanobubbles; neoplasm cells; neoplasms; peptides; thrombin; thrombosis; tissues; ultrasonics;     Show all 13 Subjects
Abstract:
... Embolization therapy is an attractive strategy for antitumor therapy, especially for solid tumors. In vivo self-coagulation behavior holds great potential in a new type of tumor embolization therapy. However, spatiotemporal controllable in situ formation of thrombus in tumor is a challenge. Herein, an ultrasound (US)-responsive ultra-sensitive “thrombus constructor” (UUNC), which was prepared by l ...
DOI:
10.1016/j.jconrel.2019.12.029

20. Prevalence and impact of cholecystitis on outcome in dogs with gallbladder mucocele

Author:
Rogers, Erin; Jaffey, Jared A.; Graham, Amber; Hostnik, Eric T.; Jacobs, Casandra; Fox‐Alvarez, William; Van Eerde, Eric; Arango, John; Williams, Fred, III; DeClue, Amy E.
Source:
Journal of veterinary emergency and critical care 2020 v.30 no.1 pp. 97-101
ISSN:
1479-3261
Subject:
necrosis,   etc   ; anti-infective agents; cholecystitis; comorbidity; dog diseases; dogs; gall bladder; histopathology; retrospective studies; surgery;     Show all 10 Subjects
Abstract:
... BACKGROUND: Gallbladder mucocele is a potentially life‐threatening extrahepatic biliary disease in dogs. The primary aims of this study were to evaluate the prevalence of cholecystitis in dogs with gross and histopathologically confirmed gallbladder mucocele and to investigate if there is an association between cholecystitis, including its subtypes (eg, acute, acute on chronic, with necrosis, chro ...
DOI:
10.1111/vec.12910