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1. Relationship between the expression of TNFR1-RIP1/RIP3 in peripheral blood and cognitive function in occupational Al-exposed workers: A mediation effect study

Author:
Zhang, Jingsi; Hao, Yanxia; Wang, Yanni; Han, Yingchao; Zhang, Shuhui; Niu, Qiao
Source:
Chemosphere 2021 v.278 pp. 130484
ISSN:
0045-6535
Subject:
tumor necrosis factor receptors; tumor necrosis factor-alpha,   etc   ; aluminum; cognition; cognitive disorders; macrophages; necroptosis; neuroglia; toxicity;     Show all 9 Subjects
Abstract:
... Aluminium (Al), not essential for biological activities, accumulates in the tissues. It exerts toxic effects on the nervous system, inducing in humans’ irreversible cognitive impairment. In this study, a cluster sampling method was used to observe the cognitive function of long-term occupational Al-exposed workers in a large Al factory, and determine the expression of peripheral blood tumour necro ...
DOI:
10.1016/j.chemosphere.2021.130484

2. 5-((7-Chloro-6-fluoro-1h-indol-3-yl) methyl)-3-methylimidazolidine-2,4-dione as a RIP1 inhibitor protects LPS/D-galactosamine-induced liver failure

Author:
Li, Aichun; Yang, Qin; Lou, Guohua; Liu, Yanning; Xia, Hongguang; Chen, Zhi
Source:
Life sciences 2021 v.273 pp. 119304
ISSN:
0024-3205
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; ; humans; liver; liver failure; necroptosis; therapeutics;     Show all 8 Subjects
Abstract:
... Necroptosis, an inflammatory form of regulated necrosis mediated by receptor-interacting kinase 1 (RIP1), RIP3, and pseudokinase mixed lineage kinase domain-like protein (MLKL) is extensively implicated in liver inflammatory disease. Thus identification small-molecule inhibitor of necroptosis has emerged as a potential therapeutic strategy to prevent liver damage. In this study, we identified 5-(( ...
DOI:
10.1016/j.lfs.2021.119304

3. Cerebral Microangiopathy in Two Dogs with Cutaneous and Renal Glomerular Vasculopathy

Author:
Pisco, Vera; Beck, Sam; Walker, Joshua JA.; Lopes, Bruno; Ives, Edward; Holm, Laura P.; Walker, David J.
Source:
Journal of comparative pathology 2021 v.184 pp. 95-100
ISSN:
0021-9975
Subject:
necrosis,   etc   ; brain; complement; electrolytes; etiology; histopathology; humans; kidneys; microangiopathy; pathophysiology;     Show all 10 Subjects
Abstract:
... Cutaneous and renal glomerular vasculopathy (CRGV) is an emerging disease in the UK, but its aetiology remains unclear. It is considered a thrombotic microangiopathy (TMA) in which the kidney and skin are the most commonly affected organs. We now document two cases of CRGV with brain lesions, which may have accounted for neurological signs displayed by these animals. The histopathological brain le ...
DOI:
10.1016/j.jcpa.2021.03.001

4. The use of near infrared fluorescence imaging with indocyanine green for vascular visualization in caudal auricular flaps in two cats

Author:
Quinlan, Adam S. F.; Wainberg, Shannon H.; Phillips, Erin; Oblak, Michelle L.
Source:
Veterinary surgery 2021 v.50 no.3 pp. 677-686
ISSN:
0161-3499
Subject:
necrosis,   etc   ; cameras; case studies; excision; eyelids; fluorescence; regrowth;     Show all 7 Subjects
Abstract:
... OBJECTIVES: To describe the use of near infrared fluorescence (NIRF) imaging with indocyanine green (ICG) for vascular visualization in two caudal auricular axial pattern flaps (APF). ANIMALS: Two client‐owned cats with upper eyelid masses. STUDY DESIGN: Clinical case report. METHODS: Wide surgical excision with enucleation was performed by using a caudal auricular APF for closure. Flap margins an ...
DOI:
10.1111/vsu.13577

5. Correlation between Tumour Associated Macrophage (TAM) Infiltration and Mitotic Activity in Canine Soft Tissue Sarcomas

Author:
Finotello, Riccardo; Whybrow, Kate; Scarin, Giulia; Ressel, Lorenzo
Source:
Animals 2021 v.11 no.3
ISSN:
2076-2615
Subject:
necrosis,   etc   ; animal pathology; carcinosarcoma; dogs; histology; macrophages; mitosis; tissues;     Show all 8 Subjects
Abstract:
... Tumour-associated macrophages (TAMs) are an important part of the tumour microenvironment but knowledge of their distribution in canine soft tissue sarcomas (STSs) is limited to absent. We analysed 38 STSs retrieved from the veterinary pathology archive; oral and visceral STSs, synovial cell sarcoma, tumours of histiocytic origin, haemangiosarcoma, carcinosarcomas, and undifferentiated tumours wer ...
DOI:
10.3390/ani11030684

6. Morphology, Physiology and Analysis Techniques of Grapevine Bud Fruitfulness: A Review

Author:
Monteiro, Ana I.; Malheiro, Aureliano C.; Bacelar, Eunice A.
Source:
Agriculture (Basel) 2021 v.11 no.2
ISSN:
2077-0472
Subject:
necrosis,   etc   ; Vitis; agriculture; dormancy; fruit quality; information; yield forecasting;     Show all 7 Subjects
Abstract:
... Grapevine reproductive development extends over two growing seasons (vegetative cycles), for the complete formation of inflorescences and clusters. Induction and floral differentiation, the mechanism that leads to the formation of reproductive structures inside dormant buds, is a complex process divided into three well-defined stages (formation of anlagen, inflorescence primordia and flowers). Thi ...
DOI:
10.3390/agriculture11020127

7. Antiquity and fundamental processes of the antler cycle in Cervidae (Mammalia)

Author:
Rössner, Gertrud E.; Costeur, Loïc; Scheyer, Torsten M.
Source:
Die Naturwissenschaften 2021 v.108 no.1 pp. 3
ISSN:
0028-1042
Subject:
necrosis,   etc   ; Cervidae; Miocene epoch; abscission; deer; evolution; fossils; histology; Europe;     Show all 9 Subjects
Abstract:
... The origins of the regenerative nature of antlers, being branched and deciduous apophyseal appendages of frontal bones of cervid artiodactyls, have long been associated with permanent evolutionary precursors. In this study, we provide novel insight into growth modes of evolutionary early antlers. We analysed a total of 34 early antlers affiliated to ten species, including the oldest known, dating ...
DOI:
10.1007/s00114-020-01713-x

8. Osseous lesions in the distal extremities of dogs with strangulating hair mats

Author:
Watson, Elizabeth; Niestat, Laura
Source:
Veterinary radiology & ultrasound 2021 v.62 no.1 pp. 37-43
ISSN:
1058-8183
Subject:
necrosis,   etc   ; atrophy; lymphatic system; radiography; radiology; tissues; ultrasonics;     Show all 7 Subjects
Abstract:
... Strangulating hair mats in dogs are characterized as soft tissue injury secondary to chronically matted hair, which can encircle the extremities and constrict lymphatic tissue and local vasculature. As the tissue swells, the hair constriction tightens and may result in tissue necrosis and osseous changes secondary to ischemic necrosis. The objectives of this retrospective case series were to descr ...
DOI:
10.1111/vru.12924

9. Limosilactobacillus reuteri ATCC PTA 5289 and DSM 17938 as adjuvants to improve evolution of pharyngitis/tonsillitis in children: randomised controlled trial

Author:
Maya-Barrios, A.; Lira-Hernandez, K.; Jiménez-Escobar, I.; Hernández, L.; Ortiz-Hernandez, A.; Jiménez-Gutiérrez, C.; López-Velázquez, G.; Gutiérrez-Castrellón, P.
Source:
Beneficial microbes 2021 v.12 no.2 pp. 137-145
ISSN:
1876-2891
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; biomarkers; evolution; fever; immunoglobulin A; nose; pharyngitis; placebos; probiotics; randomized clinical trials;     Show all 11 Subjects
Abstract:
... Pharyngitis and tonsillitis are the most common acute respiratory infections (ARIs) in children aged ≤5 years. The analysis of published data showed that some probiotics could decrease the frequency and number of days with ARIs. This study evaluated the safety and efficacy of Limosilactobacillus reuteri ATCC PTA 5289 and DSM 17938 to reduce the duration and severity of ARI symptoms. This randomise ...
DOI:
10.3920/BM2020.0171

10. The Human Milk Oligosaccharides 3‐FL, Lacto‐N‐Neotetraose, and LDFT Attenuate Tumor Necrosis Factor‐α Induced Inflammation in Fetal Intestinal Epithelial Cells In Vitro through Shedding or Interacting with Tumor Necrosis Factor Receptor 1

Author:
Cheng, Lianghui; Kong, Chunli; Wang, Wenjia; Groeneveld, Andre; Nauta, Arjen; Groves, Matthew R.; Kiewiet, Mensiena B. G.; de Vos, Paul
Source:
Molecular nutrition & food research 2021 v.65 no.7 pp. e2000425
ISSN:
1613-4125
Subject:
necrosis; tumor necrosis factor receptors,   etc   ; adults; breast milk; food research; inflammation; interleukin-8; neoplasms; nutrition; oligosaccharides; secretion;     Show all 11 Subjects
Abstract:
... SCOPE: Human milk oligosaccharides (hMOs) can attenuate inflammation by modulating intestinal epithelial cells, but the mechanisms of action are not well‐understood. Here, the effects of hMOs on tumor necrosis factor‐α (TNF‐α) induced inflammatory events in gut epithelial cells are studied. METHODS AND RESULTS: The modulatory effects of 2’‐fucosyllactose, 3‐fucosyllactose (3‐FL), 6’‐sialyllactose, ...
DOI:
10.1002/mnfr.202000425

11. A dual redox-responsive supramolecular polymer driven by molecular recognition between bisporphyrin and trinitrofluorenone

Author:
Hisano, Naoyuki; Hirao, Takehiro; Haino, Takeharu
Source:
Chemical communications 2020 v.56 no.55 pp. 7553-7556
ISSN:
1364-548X
Subject:
tumor necrosis factors,   etc   ; oxidation; polymers;     Show all 3 Subjects
Abstract:
... A dual redox-responsive supramolecular polymer driven by molecular recognition between bisporphyrin (bisPor) and trinitrofluorenone (TNF) has been developed. The supramolecular polymer was degraded into monomers in response to both oxidation and reduction stimuli. ...
DOI:
10.1039/d0cc02474k

12. Oral vaccine against IPNV based on antibiotic-free resistance recombinant Lactobacillus casei expressing CK6-VP2 fusion protein

Author:
Hua, Xiaojing; Zhou, Ying; Feng, Ying; Duan, Kexin; Ren, Xuanyu; Sun, Jinhui; Gao, Shuai; Wang, Na; Li, Jiahui; Yang, Jiawei; Xia, Dong; Li, Chunyue; Guan, Xueting; Shi, Wen; Liu, Min
Source:
Aquaculture 2021 v.535 pp. 736425
ISSN:
0044-8486
Subject:
Infectious pancreatic necrosis virus; necrosis,   etc   ; Lactobacillus casei; Oncorhynchus mykiss; antibiotic resistance; aquaculture; biosafety; chemokines; chloramphenicol; edible vaccines; genetic engineering; green fluorescent protein; hemorrhage; hepatopancreas; immunogenicity; juveniles; reporter genes;     Show all 17 Subjects
Abstract:
... Infectious pancreatic necrosis (IPN) is a disease caused by the infectious pancreatic necrosis virus (IPNV). The condition is associated with highly fatal hemorrhage and putrescence of hepatopancreas in fry and juvenile salmonids, resulting in significant economic losses. The conventionally developed recombinant Lactobacillus casei oral vaccines against IPNV use antibiotic resistance as a selectab ...
DOI:
10.1016/j.aquaculture.2021.736425

13. Antiviral activities of sea perch type I and type II IFNs against RGNNV and their different roles in antigen presentation

Author:
Lu, Xiaobing; Zeng, Junwei; Jia, Kuntong; Yi, Meisheng
Source:
Aquaculture 2021 v.534 pp. 736314
ISSN:
0044-8486
Subject:
Redspotted grouper nervous necrosis virus; necrosis,   etc   ; Lateolabrax japonicus; antigen presentation; aquaculture; freshwater fish; immunomodulation; interferons; kidneys; perch; polyinosinic-polycytidylic acid; tissue distribution;     Show all 12 Subjects
Abstract:
... Viral nervous necrosis disease, caused by nervous necrosis virus (NNV), is one of the most serious diseases in many marine and freshwater fish species worldwide. To better understand the antiviral ability and immunoregulatory function of sea perch (Lateolabrax japonicus) interferon (IFN) to NNV infection, three type I IFN genes (IFNc, IFNd and IFNh) and two type II IFN genes (IFNγ and IFNγ rel) we ...
DOI:
10.1016/j.aquaculture.2020.736314

14. Biological anti-psoriatic therapy profoundly affects high-density lipoprotein function

Author:
Trakaki, Athina; Wolf, Peter; Weger, Wolfgang; Eichmann, Thomas O.; Scharnagl, Hubert; Stadler, Julia T.; Salmhofer, Wolfgang; Knuplez, Eva; Holzer, Michael; Marsche, Gunther
Source:
Biochimica et biophysica acta 2021 v.1866 no.7 pp. 158943
ISSN:
1388-1981
Subject:
necrosis,   etc   ; aryldialkylphosphatase; blood serum; high density lipoprotein cholesterol; mortality; phosphatidylcholine-choline acyltransferase; psoriasis; risk; therapeutics;     Show all 9 Subjects
Abstract:
... Psoriasis is a common chronic inflammatory skin disease linked to increased cardiovascular risk. Functional impairment of high-density lipoprotein (HDL) may contribute to excessive cardiovascular mortality in psoriasis patients. Anti-cytokine therapies with biologics have been efficiently used for the management of psoriasis, however little data is available on the effects of biologic anti-psoriat ...
DOI:
10.1016/j.bbalip.2021.158943

15. Evaluation of probiotics for inhibiting hyperproliferation and inflammation relevant to psoriasis in vitro

Author:
Deng, Yadan; Fang, Zhifeng; Cui, Shumao; Zhao, Jianxin; Zhang, Hao; Chen, Wei; Lu, Wenwei
Source:
Journal of functional foods 2021 v.81 pp. 104433
ISSN:
1756-4646
Subject:
necrosis,   etc   ; Bifidobacterium animalis; Lactobacillus paracasei; inflammation; interleukins; neoplasms; people; probiotics; psoriasis; sequence analysis; therapeutics;     Show all 11 Subjects
Abstract:
... Due to the complexity of psoriasis, people have been searching for better treatment methods, and probiotics therapy is gaining acceptance. In this study, tumor necrosis factor-α (TNF-α) was used to stimulate abnormal proliferation of HaCaT cells, and the inhibitory effects of potential probiotics supernatants on hyperproliferation were compared. Among 102 strains, two with better suppressive effec ...
DOI:
10.1016/j.jff.2021.104433

16. Periodic mesoporous organosilica-coated magnetite nanoparticles combined with lipiodol for transcatheter arterial chemoembolization to inhibit the progression of liver cancer

Author:
Liu, Li; Xu, Xiangxian; Liang, Xianxian; Zhang, Xiang; Wen, Jun; Chen, Kun; Su, Xiaodan; Ma, Ye; Teng, Zhaogang; Lu, Guangming; Xu, Jian
Source:
Journal of colloid and interface science 2021 v.591 pp. 211-220
ISSN:
0021-9797
Subject:
necrosis,   etc   ; biocompatibility; doxorubicin; drug therapy; emulsions; hepatoma; histology; humans; liver; magnetism; magnetite; organosilicon compounds; porous media;     Show all 13 Subjects
Abstract:
... Transcatheter arterial chemoembolization (TACE) is standard locoregional therapy for hepatocellular carcinoma (HCC) that involves the injection of chemotherapeutic drugs with embolic agents into tumor tissues through intra-arterial transcatheter infusion. TACE technology using lipiodol emulsion has been most widely used in the treatment of human HCC. However, lipiodol emulsions with anticancer dru ...
DOI:
10.1016/j.jcis.2021.02.022

17. Potential of Forsythoside I as a therapeutic approach for acute lung injury: Involvement of TXNIP/NLRP3 inflammasome

Author:
Liang, Hongwen; Liu, Kai; Zhuang, Zhe; Sun, Hong; Sun, Bo; Jiao, Minna; Cai, Yeqian; Cai, Guofeng
Source:
Molecular immunology 2021 v.134 pp. 192-201
ISSN:
0161-5890
Subject:
necrosis,   etc   ; apoptosis; cell viability; cytokines; dose response; edema; inflammasomes; inflammation; lungs; mice; oxidative stress; therapeutics;     Show all 12 Subjects
Abstract:
... To explore the role of Forsythoside I (FI) in acute lung injury (ALI) mouse and its underling mechanism.The cell models of ALI are constructed by LPS induction. After pretreatment with different concentrations of FI, the lung injury is assessed by pathological changes of lung tissues and cell apoptosis. The cell viability, levels of pro-inflammatory cytokines, and the activation of TXNIP/NLRP3 pat ...
DOI:
10.1016/j.molimm.2021.03.004

18. Proteasome subunit beta type-8 from sevenband grouper negatively regulates cytokine responses by interfering NF-κB signaling upon nervous necrosis viral infection

Author:
krishnan, Rahul; Kim, Jong-Oh; Jang, Yo-Seb; Oh, Myung-Joo
Source:
Fish & shellfish immunology 2021 v.113 pp. 118-124
ISSN:
1050-4648
Subject:
necrosis,   etc   ; cytopathogenicity; grouper; interferons; interleukin-6; interleukin-8; proteasome endopeptidase complex; shellfish; viral load; viruses;     Show all 10 Subjects
Abstract:
... During viral infection, proper regulation of immune signaling is essential to ensure successful clearance of virus. Immunoproteasome is constitutively expressed and gets induced during viral infection by interferon signaling and contributes to regulate proinflammatory cytokine production and activation of the NF-κB pathway. In this study, we identified Hs-PSMB8, a member of the proteasome β-subuni ...
DOI:
10.1016/j.fsi.2021.04.004

19. Dust exposure and pulmonary inflammation in Standardbred racehorses fed dry hay or haylage: A pilot study

Author:
Olave, C.J.; Ivester, K.M.; Couetil, L.L.; Kritchevsky, J.E.; Tinkler, S.H.; Mukhopadhyay, A.
Source:
The veterinary journal 2021 v.271 pp. 105654
ISSN:
1090-0233
Subject:
necrosis,   etc   ; Standardbred; alfalfa hay; dust; endotoxins; forage; haylage; inflammation; interleukin-4; neoplasms; neutrophils;     Show all 11 Subjects
Abstract:
... Respirable dust exposure is linked to airway inflammation in racehorses. Feeding haylage may reduce dust exposure by 60–70%. The objective of this study was to compare dust exposure, airway cytology, and inflammatory cytokine concentrations between horses fed haylage or hay over 6 weeks while in training. Seven healthy Standardbred horses were randomly assigned to be fed alfalfa hay (n = 3) or gra ...
DOI:
10.1016/j.tvjl.2021.105654

20. Pigeon adenovirus and pigeon torque teno virus associated with acute multifocal hepatic necrosis in pigeons in Queensland, Australia

Author:
Agnihotri, Kalpana; Smith, Craig; Oakey, Jane; Storie, Greg
Source:
Archives of virology 2021 v.166 no.5 pp. 1469-1475
ISSN:
0304-8608
Subject:
necrosis,   etc   ; ; Adenoviridae; Alphatorquevirus; biosecurity; body condition; cell culture; hepatocytes; histopathology; liver; nose; pigeons; virology; viruses; Queensland;     Show all 15 Subjects
Abstract:
... In 2018, an outbreak resulting in deaths of 28 breeding pigeons was reported north of Brisbane, Australia. The affected birds had runny nasal discharge and poor body condition. Two birds were submitted to Biosecurity Sciences Laboratory, Brisbane, for investigation. A range of diagnostic tests excluded a number of known pathogens, and no virus was isolated in cell culture. Histopathological examin ...
DOI:
10.1007/s00705-021-05033-x