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1. Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo

Author:
Jixuan Ma; Yujia Xie; Yiju Xu; Pei Gu; Yingdie Zhang; Lieyang Fan; Yun Zhou; Haijiao Wang; Ting Zhou; Jintong He; Dongming Wang; Weihong Chen
Source:
Journal of environmental sciences (China) 2023 v.126 pp. 772-783
ISSN:
1001-0742
Subject:
necrosis,   etc   ; antibodies; collagen; environmental exposure; epithelium; fibroblasts; fibrosis; gelatinase A; glycoproteins; inflammation; interleukin-11; interleukin-6; lungs; mice; mitogen-activated protein kinase; neoplasms; neutralization; silica; therapeutics; China;     Show all 20 Subjects
Abstract:
... Environmental exposure to crystalline silica particles can lead to silicosis, which is one of the most serious pulmonary interstitial fibrosis around the world. Unfortunately, the exact mechanism on silicosis is unclear, and the effective treatments are lacking to date. In this study, we aim to explore the molecular mechanism by which interleukin-11 (IL-11) affects silica particles-induced lung in ...
DOI:
10.1016/j.jes.2022.03.015

2. Comparing the CT and MRI findings for canine primary hepatocellular lesions

Author:
Shohei Kurokawa; Toshiyuki Tanaka; Hiroki Yamazaki; Shunsuke Noguchi; Yusuke Wada; Hidetaka Nishida; Hideo Akiyoshi
Source:
Veterinary record 2022 v.190 no.11 pp. e1083
ISSN:
0042-4900
Subject:
necrosis,   etc   ; dogs; gadolinium; hyperplasia;     Show all 4 Subjects
Abstract:
... BACKGROUND: Triple‐phase CT and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA) MRI have been used to differentiate hepatocellular carcinomas (HCCs) in dogs. METHODS: This retrospective case series aimed to compare the CT findings with MRI findings of 20 canine hepatocellular lesions, including eight poorly/moderately‐differentiated HCCs, eight well‐differentiated HCCs an ...
DOI:
10.1002/vetr.1083

3. Target identification and occupancy measurement of necrosis avid agent rhein using bioorthogonal chemistry-enabling probes

Author:
Cuihua Jiang; Jian Zhang; Shihe Hu; Meng Gao; Dongjian Zhang; Nan Yao; Qiaomei Jin
Source:
RSC advances 2022 v.12 no.26 pp. 16491-16495
ISSN:
2046-2069
Subject:
necrosis,   etc   ; DNA; biomarkers; chemistry;     Show all 4 Subjects
Abstract:
... Necrosis is an important biomarker, which only occurs in pathological situations. Tracking of necrosis avid agents is of crucial importance toward understanding their mechanisms. Herein, we developed a modular probe strategy based on bioorthogonal copper-free click chemistry. Structural modification of rhein with transcyclooctene (TCO) led to the identification of rhein-TCO2 as the most active pro ...
DOI:
10.1039/d2ra02844a

4. A comprehensive approach to assess marine macro litter pollution and its impacts on corals in the Bangka Strait, North Sulawesi, Indonesia

Author:
Jasmin S. Mueller; Nicolas Bill; Marco S. Reinach; Markus T. Lasut; Holger Freund; Peter J. Schupp
Source:
Marine pollution bulletin 2022 v.175 pp. 113369
ISSN:
0025-326X
Subject:
necrosis,   etc   ; algae; marine pollution; microhabitats; Indonesia;     Show all 5 Subjects
Abstract:
... This is a comprehensive study showing the marine anthropogenic litter pollution within North Sulawesi, Indonesia. From an area of 2972 m² that encompassed five sparsely populated locations, a total of 9421 litter items weighing 137 kg were collected. One location (Talisei North) contributed 50% of all collected litter items. Plastic litter always dominated with 96–99%. Litter was unevenly distribu ...
DOI:
10.1016/j.marpolbul.2022.113369

5. Neurological and gastrointestinal manifestations of spontaneous poisoning by Ricinus communis in goats

Author:
Mizael Machado; Cintia R.R. Queiroz; Tais M. Wilson; Davi E.R. Sousa; Benito Soto-Blanco; Aníbal G. Armién; Severo S. Barros; Franklin Riet-Correa; Márcio B. Castro
Source:
Toxicon 2022 v.214 pp. 74-77
ISSN:
0041-0101
Subject:
necrosis,   etc   ; Ricinus communis; gastroenteritis; hepatocytes; liver; toxicity testing;     Show all 6 Subjects
Abstract:
... An outbreak of Ricinus communis poisoning in goats with neurological and digestive changes was related to the ingestion of different vegetative parts of the plant. Two poisoned animals died within 5 h of the plant intake showing necrotic gastroenteritis and hepatocytes degeneration and necrosis. Toxicological analysis by HPLC-DAD assay demonstrated 21.1–25.1 μg/g of ricinine in samples of ruminal ...
DOI:
10.1016/j.toxicon.2022.05.004

6. Early Antibiotic Exposure Alters Intestinal Development and Increases Susceptibility to Necrotizing Enterocolitis: A Mechanistic Study

Author:
Hala Chaaban; Maulin M. Patel; Kathryn Burge; Jeffrey V. Eckert; Cristina Lupu; Ravi S. Keshari; Robert Silasi; Girija Regmi; MaJoi Trammell; David Dyer; Steven J. McElroy; Florea Lupu
Source:
Microorganisms 2022 v.10 no.3 pp. -
ISSN:
2076-2607
Subject:
necrosis,   etc   ; antibiotics; cell proliferation; enterocolitis; inflammation; intestines; mortality; therapeutics;     Show all 8 Subjects
Abstract:
... Increasing evidence suggests that prolonged antibiotic therapy in preterm infants is associated with increased mortality and morbidities, such as necrotizing enterocolitis (NEC), a devastating gastrointestinal pathology characterized by intestinal inflammation and necrosis. While a clinical correlation exists between antibiotic use and the development of NEC, the potential causality of antibiotics ...
DOI:
10.3390/microorganisms10030519

7. Use of subdermal hyaluronic acid injections and a free labial mucocutaneous graft for the repair of feline eyelid agenesis

Author:
Kelly A Caruso; Benjamin D Reynolds; Cameron J Whittaker; Jeffrey S Smith; William M Irving; Paul G McCarthy; Negar Hamzianpour; Gladys Boo
Source:
Veterinary ophthalmology 2022 v.25 no.3 pp. 209-218
ISSN:
1463-5216
Subject:
necrosis,   etc   ; cats; cornea; eyelids; hyaluronic acid; keratitis; ophthalmology; tissues;     Show all 8 Subjects
Abstract:
... OBJECTIVE: To describe a technique to repair feline eyelid agenesis using a hyaluronic acid (HA) subdermal filler injection to allow for acute soft tissue expansion, followed by a free labial mucocutaneous graft. MATERIALS AND METHODS: Thirty‐nine colobomatous eyelids in 24 feline patients with secondary keratitis were recruited to the study group. RESULTS: Keratitis and trichiasis were markedly r ...
DOI:
10.1111/vop.12963

8. Hydrogen-Rich Water Alleviates the Nickel-Induced Toxic Responses (Inflammatory Responses, Oxidative Stress, DNA Damage) and Ameliorates Cocoon Production in Earthworm

Author:
Mine Köktürk; Serkan Yıldırım; Gizem Eser; Menekşe Bulut; Duried Alwazeer
Source:
Biological trace element research 2022 v.200 no.7 pp. 3442-3452
ISSN:
0163-4984
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; DNA damage; chlorides; earthworms; ecosystems; epithelium; histopathology; muscles; nickel; oxidative stress; polluted soils; protective effect; reactive oxygen species; research; toxicity;     Show all 16 Subjects
Abstract:
... In recent years, studies investigating the protective effect of hydrogen-rich water (HRW) against different diseases and the toxicity of some substances have attracted increasing attention. Here, we assessed the effects of hydrogen-rich water on different nickel-induced toxic responses (reactive oxygen species (ROS), tumor necrosis factor-alpha (TNF-α), and 8-hydroxy-2′-deoxyguanosine (8-OHdG) of ...
DOI:
10.1007/s12011-021-02908-7

9. Toll-crustin signaling pathway is activated in the Eriocheir sinensis with hepatopancreatic necrosis disease (HPND)

Author:
Ximei Nie; Yuqi Zhao; Hao Xu; Zhengxiao Han; Xing Zhang; Bingzhi Li; Xin Huang; Jiachun Ge; Qian Ren
Source:
Aquaculture 2022 v.552 pp. 738032
ISSN:
0044-8486
Subject:
necrosis,   etc   ; Eriocheir sinensis; aquaculture; crustin; genes; innate immunity; intestines; starvation; whey;     Show all 9 Subjects
Abstract:
... The occurrence of hepatopancreatic necrosis disease (HPND) puts pressure on the healthy aquaculture and development of Chinese mitten crab, Eriocheir sinensis. Research on the mechanism of innate immunity regulation in crabs with HPND is limited. We studied the effects of HPND on the expression of Toll receptor and crustin gene, as well as the relationship between Toll and the synthesis of crustin ...
DOI:
10.1016/j.aquaculture.2022.738032

10. An albumin scaffold grafted with an alpha-helical motif delivers therapeutic payloads by modular coiled-coil assembly

Author:
Parastou Rahimizadeh; Jeong Eun Lee; Dae-Hee Lee; Sung In Lim
Source:
International journal of biological macromolecules 2022 v.205 pp. 376-384
ISSN:
0141-8130
Subject:
necrosis,   etc   ; green fluorescent protein; half life; human serum albumin; ligands; neoplasms; pH; therapeutics;     Show all 8 Subjects
Abstract:
... A short in vivo half-life of protein-based therapeutics often restricts successful clinical translation despite their promising efficacy in vitro. As a biocompatible half-life extender, human serum albumin (HSA) has proven effective in some cases. While genetic fusion is well-established for interlinking HSA and a protein payload, it is limited to structurally simple proteins, necessitating new st ...
DOI:
10.1016/j.ijbiomac.2022.02.040

11. Cold Lateral Condensation Root Canal Treatment to Retain Fractured Canines of a Ferret (Mustela putorius furo)

Author:
Emily Gover; Dylan Rakhra
Source:
Journal of exotic pet medicine 2022 v.41 pp. 26-29
ISSN:
1557-5063
Subject:
necrosis,   etc   ; abscess; cold; dogs; equipment; ferrets; males; medicine; morbidity; pulp; sodium hypochlorite; therapeutics;     Show all 12 Subjects
Abstract:
... Root canal therapy has decreased morbidity compared to extraction, but it is underutilised in the first opinion practice due to assumed skill and knowledge requirements. Fractures of ferret (Mustela putorius furo) canines are common due to their anatomy and function. Penetration of bacteria into exposed pulp tissue leads to pain, inflammation, pulp necrosis, abscess and swelling. Therefore, tooth ...
DOI:
10.1053/j.jepm.2022.02.006

12. Vascular occlusion associated with abiotic stress is a causal agent of silvertop in perennial grasses

Author:
Juliana J. Soroka; Garry L. Lees; Bruce D. Gossen
Source:
Canadian journal of plant science 2022 v.102 no.3 pp. 690-697
ISSN:
1918-1833
Subject:
necrosis,   etc   ; Bromus riparius; Poa pratensis; abiotic stress; cold season; fungi; insects; leaves; mycelium;     Show all 9 Subjects
Abstract:
... Silvertop (sterile heads) of perennial cool-season grasses is common in aging stands grown for seed production. It is associated with yield reduction, but the causal agent(s) has not been determined. A study was conducted to examine the cytology of grass tillers with and without silvertop. A series of cross sections of stems from field samples of Kentucky bluegrass and meadow bromegrass (where sig ...
DOI:
10.1139/CJPS-2021-0232

13. A preliminary study on multi-level biomarkers response of the tropical oyster Crassostrea brasiliana to exposure to the antifouling biocide DCOIT

Author:
Bruno Galvão de Campos; Mayana Karoline Fontes; Paloma Kachel Gusso-Choueri; Gabriela Pustiglione Marinsek; Caio Rodrigues Nobre; Beatriz Barbosa Moreno; Fiamma Eugenia Lemos Abreu; Gilberto Fillmann; Renata de Britto Mari; Denis Moledo de Souza Abessa
Source:
Marine pollution bulletin 2022 v.174 pp. 113241
ISSN:
0025-326X
Subject:
necrosis,   etc   ; Crassostrea brasiliana; Neotropics; biocides; biomarkers; epithelium; histology; histopathology; marine pollution; oxidative stress; oysters;     Show all 11 Subjects
Abstract:
... This study investigated the sublethal effects of environmentally relevant concentrations of DCOIT on the neotropical oyster Crassostrea brasiliana. Gills and digestive glands of animals exposed to increasing concentrations of DCOIT were analyzed for biochemical, cellular, and histopathological responses. Exposure to DCOIT (0.2 to 151 μg L⁻¹) for 120 h triggered oxidative stress in both tissues (th ...
DOI:
10.1016/j.marpolbul.2021.113241

14. An automatic phytopathometry system for chlorosis and necrosis severity evaluation of asian soybean rust infection

Author:
Diego Alves da Silva; Cristiane Lemes Hamawaki; Breno Cezar Marinho Juliatti; Lucas dos Santos Nascimento; Osvaldo Toshiyuki Hamawaki; Díbio Leandro Borges; Fernando Cezar Juliatti; Ana Paula Oliveira Nogueira
Source:
Computers and electronics in agriculture 2022 v.192 pp. 106542
ISSN:
0168-1699
Subject:
necrosis,   etc   ; Phakopsora pachyrhizi; agriculture; algorithms; chlorosis; cultivars; databases; electronics; farms; soybean rust; soybeans; Brazil;     Show all 12 Subjects
Abstract:
... The development of soybean cultivars resistant to Phakopsora pachyrhizi (also known as Asian Soybean Rust (ASR)) may be achieved through genetic breeding. In the stage of selecting the resistant genotypes, one factor that can be used is to observe visually the severity of the rust symptoms upon leaflets of sampled soybean plants. By being able to quantify the exact amounts of regions with chlorosi ...
DOI:
10.1016/j.compag.2021.106542

15. Material basis research for Echinacea purpurea (L.) Moench against hepatocellular carcinoma in a mouse model through integration of metabonomics and molecular docking

Author:
Wenqian Xu; Bin Hu; Yuliang Cheng; Yahui Guo; Weirong Yao; He Qian
Source:
Phytomedicine 2022 v.98 pp. 153948
ISSN:
0944-7113
Subject:
necrosis,   etc   ; Echinacea purpurea; biosynthesis; blood serum; hepatoma; histology; metabolites; metabolomics; mice; phenylalanine; tryptophan; tyrosine;     Show all 12 Subjects
Abstract:
... Echinacea purpurea (L.) Moench (EP), a well-known “immunostimulant” in the West, is one of the most popular botanicals for patients with cancer. It has been proved to be effective against hepatocellular carcinoma (HCC), while the active ingredients remains unclear. This study aimed to investigate the inhibitory effect and interpret the material basis of EP against HCC through metabolomics and mole ...
DOI:
10.1016/j.phymed.2022.153948

16. Outcome of caudal superficial epigastric axial pattern flaps in dogs and cats: 70 cases (2007‐2020)

Author:
K. Forster; L. S. Cutando; J. Ladlow; D. Anderson; C. Burton; S. Das; S. Gibson; N. Kulendra; T. Emmerson; S. Baines; L. Rutherford; R. D. Paulino; R. Fontanini; K. Compagnone; B. De La Puerta
Source:
journal of small animal practice 2022 v.63 no.2 pp. 128-135
ISSN:
0022-4510
Subject:
necrosis,   etc   ; anesthesia; dehiscence; descriptive studies; edema; etiology; hypotension; hypothermia; neoplasms; small animal practice; surgery;     Show all 11 Subjects
Abstract:
... OBJECTIVES: To describe the outcome and complications associated with the use of caudal superficial epigastric axial pattern flaps in dogs and cats. MATERIAL AND METHODS: Multicentre retrospective review and descriptive study of clinical records of dogs and cats having undergone caudal superficial epigastric axial pattern flaps between 2007 and 2020. Data retrieved included signalment, aetiology o ...
DOI:
10.1111/jsap.13467

17. Thannilignan glucoside and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative, two new compounds isolated from Terminalia bellirica

Author:
Teruhisa Manome; Yasumasa Hara; Firoj Ahmed; Samir K. Sadhu; Masami Ishibashi
Source:
Natural medicines 2022 v.76 no.2 pp. 482-489
ISSN:
1340-3443
Subject:
necrosis,   etc   ; Terminalia bellirica; cytotoxicity; glucosides; humans; ligands; methanol; neoplasm cells; neoplasms; spectral analysis; Bangladesh;     Show all 11 Subjects
Abstract:
... Two new compounds, thannilignan 9-O-β-glucoside (1) and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative (2), and seven known compounds were isolated from the methanol extract of Terminalia bellirica leaves, collected in Bangladesh. The structures of the compounds were elucidated using spectroscopic analysis. Among these isolated compounds, corilagin (3) was cytotoxic against human gastric adeno ...
DOI:
10.1007/s11418-021-01593-z

18. Thymic epithelial tumours in 51 dogs: Histopathologic and clinicopathologic findings

Author:
Andrew D. Yale; Simon L. Priestnall; Rachel Pittaway; Angela J. Taylor
Source:
Veterinary and comparative oncology 2022 v.20 no.1 pp. 50-58
ISSN:
1476-5810
Subject:
necrosis,   etc   ; dogs; epithelium; excision; histology; histopathology; mediastinum; metastasis; mitosis; myasthenia gravis; neoplasms; survival rate;     Show all 12 Subjects
Abstract:
... Canine thymic epithelial tumours (TET) are uncommon and little is known about their behaviour. Previous attempts at histologic classification have varied, and as such reliable prognostic information is unavailable. The aim of this retrospective multi‐institutional study was to evaluate cases of canine TETs, irrespective of subtype, in order to identify useful histopathologic and clinicopathologic ...
DOI:
10.1111/vco.12705

19. Vitamin C alleviates alcoholic liver injury by suppressing neutrophil infiltration in senescence marker protein 30-knockout mice irrespective of its antioxidant effects

Author:
Su-Min Baek; Seoung-Woo Lee; Young-Jin Lee; Seong-Kyoon Choi; Hee-Yeon Kim; Min-Soo Seo; Soo-Eun Sung; A-Rang Lee; Tae-Un Kim; Se-Hyeon Han; Jun-Hyeok Son; Sang-Joon Park; Tae-Hwan Kim; Kyu-Shik Jeong; Jin-Kyu Park
Source:
Life sciences 2022 v.297 pp. 120228
ISSN:
0024-3205
Subject:
necrosis,   etc   ; alcohol drinking; antioxidants; apoptosis; ascorbic acid; diet; ethanol; liver; liver diseases; neutrophils; therapeutics;     Show all 11 Subjects
Abstract:
... Alcoholic liver disease (ALD) comprises an important component in chronic liver diseases, and its clinical significance has increased due to the high consumption of alcohol worldwide. Vitamin C is a potent antioxidant, and several previous studies have suggested that its therapeutic role in ALD is derived from its antioxidant role. However, its anti-inflammatory role in ALD remains to be elucidate ...
DOI:
10.1016/j.lfs.2021.120228

20. p38 MAPK is involved in the sustained loss of endothelial barrier function induced by Tumor Necrosis Factor-α

Author:
William P. Furman; Alvin J. Sullivan; Alexander J. Bitterman; Joshua P. Garrett
Source:
Bios 2022 v.92 no.4 pp. 117-126
ISSN:
0005-3155
Subject:
necrosis,   etc   ; blood vessels; endothelium; inflammation; mitogen-activated protein kinase; neoplasms; permeability; therapeutics; tight junctions;     Show all 9 Subjects
Abstract:
... The endothelium is a monolayer of cells which line all of the vasculature where it acts as a barrier to control permeability of water and other molecules out of a blood vessel. Loss of endothelial barrier function resulting in increased endothelial permeability is often seen in pathological inflammation leading to organ damage. The inflammatory cytokine TNF-α activates several different signaling ...
DOI:
10.1893/BIOS-D-20-00002