PubAg

Main content area

You searched for: Subject "necrosis" Remove constraint Subject: "necrosis"
Start Over

Search

21,181  Search Results

« Previous | 1 - 20 of 21,181 |
Number of results to display per page

Search Results

1. Scalable Total Synthesis of (−)-Vinigrol

Author:
Yu, Xuerong; Xiao, Lianghong; Wang, Zechun; Luo, Tuoping
Source:
Journal of the American Chemical Society 2019 v.141 no.8 pp. 3440-3443
ISSN:
1520-5126
Subject:
tumor necrosis factor-alpha,   etc   ; medicinal properties; stereochemistry;     Show all 3 Subjects
Abstract:
... Vinigrol is a structurally and stereochemically complex natural product that displays various potent pharmacological activities, including the capability to modulate TNF-α. A new and efficient synthetic route toward this natural product has been developed to complete the asymmetric synthesis of (−)-vinigrol and provide over 600 mg of material, manifesting the power of macrocyclic stereocontrol and ...
DOI:
10.1021/jacs.9b00621

2. Bleaching and necrosis of staghorn coral (Acropora formosa) in laboratory assays: Immediate impact of LDPE microplastics

Author:
Syakti, Agung Dhamar; Jaya, Jales Veva; Rahman, Aulia; Hidayati, Nuning Vita; Raza'i, Tengku Said; Idris, Fadliyah; Trenggono, Mukti; Doumenq, Pierre; Chou, Loke Ming
Source:
Chemosphere 2019 v.228 pp. 528-535
ISSN:
0045-6535
Subject:
necrosis,   etc   ; Acropora cervicornis; bleaching; coral polyps; microplastics; photosynthesis; polyethylene;     Show all 7 Subjects
Abstract:
... The impact of low-density polyethylene (LDPE) microplastics (<100 μm; P100-A P100-B, P100-C, 100–200 μm; P200, 200–500 μm; P500) on Acropora formosa was investigated. This study investigated the bleaching and necrosis extent of A. formosa caused by LDPE contamination via laboratory assay. The staghorn coral ingested the microplastics, resulting in bleaching and necrosis that concomitantly occurred ...
DOI:
10.1016/j.chemosphere.2019.04.156

3. A Fibromyxoid Stromal Response is Associated with Muscle Invasion in Canine Urothelial Carcinoma

Author:
de Brot, S.; Grau-Roma, L.; Stirling-Stainsby, C.; Dettwiler, M.; Guscetti, F.; Meier, D.; Scase, T.; Robinson, B.D.; Gardner, D.; Mongan, N.P.
Source:
Journal of comparative pathology 2019 v.169 pp. 35-46
ISSN:
0021-9975
Subject:
necrosis,   etc   ; bladder; carcinoma; dogs; elderly; females; inflammation; muscles; prognosis; terriers;     Show all 10 Subjects
Abstract:
... Canine urothelial carcinoma (UC) is the most common type of cancer of the lower urinary tract and tends to affect elderly neutered female dogs, with a high predisposition for Scottish terriers. Tumour stroma, inflammation and necrosis are poorly characterized in canine UC and their role as prognostic factors is unknown. The aims of this study were to (1) assess histologically 381 canine UCs, with ...
DOI:
10.1016/j.jcpa.2019.04.003

4. Raspberry-like small multicore gold nanostructures for efficient photothermal conversion in the first and second near-infrared windows

Author:
Plan SangnierThese authors contributed equally to this paper and are joint first authors., Anouchka; Aufaure, Romain; Cheong, Soshan; Motte, Laurence; Palpant, Bruno; Tilley, Richard D.; Guenin, Erwann; Wilhelm, Claire; Lalatonne, Yoann
Source:
Chemical communications 2019 v.55 no.28 pp. 4055-4058
ISSN:
1364-548X
Subject:
necrosis,   etc   ; chemical reactions; gold; nanogold; neoplasm cells; neoplasms; polyethylene;     Show all 7 Subjects
Abstract:
... Gold nanoraspberries were synthesized by a seed-mediated synthesis with polyethylene glycol-functionalized bisphosphonates. The original structure shifted the optical absorption to infrared, revealing very efficient photothermal properties within the 2nd biological transparency window and leading to cancer cell necrosis at moderate intracellular doses and low (safe) laser power. ...
DOI:
10.1039/c8cc09476d

5. Diagnostic performance of serum CK-MB, TNF-α and hs-CRP in children with viral myocarditis

Author:
Chen, Jia; Deng, Yuanying
Source:
Open life sciences 2019 v.14 no.1 pp. 38-42
ISSN:
2391-5412
Subject:
tumor necrosis factor-alpha,   etc   ; biomarkers; blood serum; children; myocarditis;     Show all 5 Subjects
Abstract:
... The purpose of this study was to investigate the diagnostic performance of serum CK-MB, TNF-α and hs-CRP in children with viral myocarditis (VMC). Fifty-six children with confirmed diagnosis of VMC were included in this study. Of the included 56 cases, 25 subjects were in acute and other 31 were in the recovery stage. A contemporaneous control group of 22 children were included for comparison. The ...
DOI:
10.1515/biol-2019-0005

6. Potential role of a disintegrin and metalloproteinase-17 (ADAM17) in age-associated ventricular remodeling of rats

Author:
Liu, Hainiang; Wang, Haoren; Cheng, Dong; Wang, Qinfu; Pei, Zuowei; Zhu, Ning; Fang, Weiyi; Yu, Qin
Source:
RSC advances 2019 v.9 no.25 pp. 14321-14330
ISSN:
2046-2069
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; Western blotting; body weight; cardiomyocytes; collagen; immunohistochemistry; inflammation; neoplasms; protein synthesis; rats;     Show all 11 Subjects
Abstract:
... Excessive tumor necrosis factor-α (TNF-α) could enhance cell death and aggravate left ventricular remodeling and myocardial dysfunction. A disintegrin and metalloproteinase-17 (ADAM17), an important maturation regulator of TNF-α, might be involved in the aging-associated ventricular remodeling. The present study observed myocardial ADAM17 expression in young and aged rats and explored the associat ...
DOI:
10.1039/c9ra01190k

7. Modulation of cytokine level and sperm quality of mice by Lycium barbarum polysaccharides

Author:
Qian, Li
Source:
International journal of biological macromolecules 2019 v.126 pp. 475-477
ISSN:
0141-8130
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; Lycium barbarum; blood serum; cyclophosphamide; interleukin-12; mice; models; polysaccharides; reproduction; sperm quality;     Show all 11 Subjects
Abstract:
... This study investigated the effect of Lycium barbarum polysaccharides (LBPs) on the cytokine level and sperm quality of mice with cyclophosphamide-induced impaired reproduction system. Sixty Kunming mice were randomly divided into five groups: a normal control group, a model control group (treated with cyclophosphamide) and three LBP groups (treated with cyclophosphamide and 0.5, 1.0 and 1.5 g/kg ...
DOI:
10.1016/j.ijbiomac.2018.12.250

8. Rapid diagnosis of Vibrio owensii responsible for shrimp acute hepatopancreatic necrosis disease with isothermal recombinase polymerase amplification assay

Author:
Liu, Liyuan; Jiang, Luzhi; Yu, Yongxin; Xia, Xiaoming; Pan, Yingjie; Yan, Shuling; Wang, Yongjie
Source:
Molecular and cellular probes 2017 v.33 pp. 4-7
ISSN:
0890-8508
Subject:
necrosis,   etc   ; Vibrio; shrimp;     Show all 3 Subjects
Abstract:
... A rapid and sensitive AHPND-RPA assay was developed for the specific detection of the AHPND-causing Vibrio owensii. The AHPND-RPA detected as few as 2 copies per reaction in 9.02 ± 0.66 min at 39 °C, and showed 100% positive predictive value and negative predictive value for AHPND diagnosis. ...
DOI:
10.1016/j.mcp.2017.02.001

9. Biological and Genetic Characterization of New and Known Necroviruses Causing an Emerging Systemic Necrosis Disease of Corn Salad (Valerianella locusta) in France

Author:
Verdin, E.; Marais, A.; Wipf-Scheibel, C.; Faure, C.; Pelletier, B.; David, P.; Svanella-Dumas, L.; Poisblaud, C.; Lecoq, H.; Candresse, T.
Source:
Phytopathology 2018 v.108 no.8 pp. 1002-1010
ISSN:
0031-949X
Subject:
Tobacco necrosis virus; Tobacco necrosis virus A; Tobacco necrosis virus D,   etc   ; Olive mild mosaic virus; Valerianella locusta; high-throughput nucleotide sequencing; necrosis; satellites; specialty crops; virology; viruses; France;     Show all 12 Subjects
Abstract:
... An emerging systemic necrosis disease of corn salad was first observed in the Nantes region of France in the late 2000s. Classical virology and high-throughput sequencing approaches demonstrated that the disease is associated with four different necroviruses: tobacco necrosis virus A (TNVA), tobacco necrosis virus D (TNVD), olive mild mosaic virus (OMMV), and a novel recombinant Alphanecrovirus fo ...
DOI:
10.1094/PHYTO-08-17-0284-R

10. Different origins of paralogues of salmonid TNR1 and TNFR2: Characterisation and expression analysis of four TNF receptor genes in rainbow trout Oncorhynchus mykiss

Author:
Hong, Suhee; Wang, Ting-Yu; Secombes, Christopher J.; Wang, Tiehui
Source:
Developmental and comparative immunology 2019 v.99 pp. 103403
ISSN:
0145-305X
Subject:
tumor necrosis factor receptors; tumor necrosis factor-alpha,   etc   ; Oncorhynchus mykiss; apoptosis; cell viability; fish; gene expression regulation; genes; glycosylation; immune response; lymphotoxin; mammals; messenger RNA; tissues; translation (genetics);     Show all 15 Subjects
Abstract:
... Mammalian TNFR1 and TNFR2 bind TNFα and TNFβ, and provide key communication signals to a variety of cell types during development and immune responses that are crucial for cell survival, proliferation and apoptosis. In teleost fish TNFβ is absent but TNFα has been expanded by the third whole genome duplication (3R WGD) and again by a 4R WGD in some lineages, leading to the four TNFα paralogues kno ...
DOI:
10.1016/j.dci.2019.103403

11. Profiling of cellular immune responses to Mycoplasma pulmonis infection in C57BL/6 and DBA/2 mice

Author:
Boonyarattanasoonthorn, Tussapon; Elewa, Yaser Hosny Ali; Tag-El-Din-Hassan, Hassan T.; Morimatsu, Masami; Agui, Takashi
Source:
Infection, genetics, and evolution 2019 v.73 pp. 55-65
ISSN:
1567-1348
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; Mycoplasma pulmonis; cell-mediated immunity; inflammation; interleukin-17; interleukin-6; lungs; lymphocytes; macrophages; mice; mycoplasmosis; neoplasms; neutrophils; pneumonia;     Show all 15 Subjects
Abstract:
... Mycoplasma infections cause respiratory tract damages and atypical pneumonia, resulting in serious problems in humans and animals worldwide. It is well known that laboratory inbred mouse strains show various susceptibility to Mycoplasma pulmonis (M. pulmonis) infection, which causes murine respiratory mycoplasmosis. In this study, we aimed to demonstrate the difference in cellular immune responses ...
DOI:
10.1016/j.meegid.2019.04.019

12. Emodin ameliorates rheumatoid arthritis by promoting neutrophil apoptosis and inhibiting neutrophil extracellular trap formation

Author:
Zhu, Mengmeng; Yuan, Kai; Lu, Qingyi; Zhu, Qingqing; Zhang, Shan; Li, Xiaohong; Zhao, Lu; Wang, Hesong; Luo, Guangbin; Wang, Ting; Huang, Guangrui; Xu, Anlong
Source:
Molecular immunology 2019 v.112 pp. 188-197
ISSN:
0161-5890
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; apoptosis; autophagy; emodin; etiology; inflammation; interferon-gamma; interleukin-6; medicinal plants; mice; models; neoplasms; neutrophils; pathogenesis; rheumatoid arthritis; therapeutics;     Show all 17 Subjects
Abstract:
... Rheumatoid arthritis (RA) is a chronic, systemic, synovitis-based inflammatory disease with unknown etiology. Neutrophils play important roles in the pathogenesis of RA. Apoptosis and NETosis of neutrophils are two major mechanisms of programmed cell death that differ in their morphological characteristics and effects on the immune system. In rheumatoid arthritis, delayed neutrophil apoptosis ampl ...
DOI:
10.1016/j.molimm.2019.05.010

13. Phenothiazine antipsychotics exhibit dual properties in pseudo-allergic reactions: Activating MRGPRX2 and inhibiting the H1 receptor

Author:
Hou, Yajing; Che, Delu; Wei, Di; Wang, Cheng; Xie, Yitong; Zhang, Kaining; Cao, Jiao; Fu, Jia; Zhou, Nan; He, Huaizhen
Source:
Molecular immunology 2019 v.111 pp. 118-127
ISSN:
0161-5890
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; G-protein coupled receptors; adverse effects; anaphylaxis; antagonists; antipsychotics; blood serum; calcium; computer simulation; enzymes; histamine; mast cells; mice; neoplasms; phenothiazine;     Show all 16 Subjects
Abstract:
... Phenothiazines are a class of antipsychotics that share the same tricyclic structure and are widely used in clinical settings. Adverse reactions from these drugs, however, have been regularly reported, with allergic skin reactions noted in some cases. Nevertheless, the mechanisms underlying anaphylaxis by these drugs have not been described. In the present study, we found that phenothiazine antips ...
DOI:
10.1016/j.molimm.2019.04.008

14. Glycine protects partial liver grafts from Kupffer cell-dependent ischemia–reperfusion injury without negative effect on regeneration

Author:
Al-Saeedi, Mohammed; Liang, Rui; Schultze, Daniel P.; Nickkholgh, Arash; Herr, Ingrid; Zorn, Markus; Schemmer, Peter
Source:
Amino acids 2019 v.51 no.6 pp. 903-911
ISSN:
0939-4451
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; Kupffer cells; blood flow; enzymes; females; fluorescence microscopy; immunohistochemistry; leukocytes; liver; liver transplant; rats; reperfusion injury;     Show all 13 Subjects
Abstract:
... Donor preconditioning with glycine prevents Kupffer cell-dependent reperfusion injury to liver grafts. Partial liver grafts need to regenerate and grow in size after transplantation; however, glycine inactivates Kupffer cells, which are important for hepatic regeneration. Thus, this study was designed to evaluate the impact of donor preconditioning with glycine after partial liver transplantation ...
DOI:
10.1007/s00726-019-02722-5

15. Protective effects of rapamycin induced autophagy on CLP septic mice

Author:
Wang, Zhenxia; Li, Yan; Yang, Xiaowei; Zhang, Lian; Shen, Huiming; Xu, Weihong; Yuan, Congli
Source:
Comparative immunology, microbiology, and infectious diseases 2019 v.64 pp. 47-52
ISSN:
0147-9571
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; animal models; animal tissues; autophagy; death; inflammasomes; inflammation; interleukin-1beta; liver; lungs; macrophages; mice; neoplasms; protective effect; rapamycin; septic shock; spleen;     Show all 18 Subjects
Abstract:
... Sepsis is a life-threatening condition that may develop to multiple organ failure and septic shock. Autophagy is considered to play an important role in the regulation of inflammation. The present study aims to investigate the protective role of mTORC1 inhibitor, rapamycin, on septic death using cecal ligation and puncture (CLP) mice model. Here, results showed that pretreatment with rapamycin red ...
DOI:
10.1016/j.cimid.2019.01.009

16. Rhamnan sulfate extracted from Monostroma nitidum attenuates blood coagulation and inflammation of vascular endothelial cells

Author:
Okamoto, Takayuki; Akita, Nobuyuki; Terasawa, Masahiro; Hayashi, Tatsuya; Suzuki, Koji
Source:
Natural medicines 2019 v.73 no.3 pp. 614-619
ISSN:
1340-3443
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; Monostroma; anti-inflammatory agents; anticoagulant activity; anticoagulants; blood coagulation; heparin; human umbilical vein endothelial cells; inflammation; lipopolysaccharides; neoplasms; rhamnose; sulfates; thrombin;     Show all 15 Subjects
Abstract:
... Rhamnan sulfate (RS) is a polysaccharide with a rhamnose backbone isolated from Monostroma nitidum. Like heparin, it exerts anticoagulant activity in the presence of antithrombin. Endothelial cells facilitate the crosstalk between blood coagulation and vascular inflammation. In this study, we compared the effect of RS with that of heparin on blood coagulation and vascular endothelial cells in the ...
DOI:
10.1007/s11418-019-01289-5

17. Ceria nanoparticles promoted the cytotoxic activity of CD8⁺ T cells by activating NF-κB signaling

Author:
TangThese authors contributed equally to this work., Shupei; Zhou, Lan; Liu, Zhenyu; Zou, Ling; Xiao, Minglu; Huang, Chunji; Xie, Zhunyi; He, Haiyang; Guo, Yanyan; Cao, Yi; Huang, Huang; Wu, Xiaoping; Meng, Dongwei; Ye, Lilin; Wu, Yuzhang; Yang, Xiaochao; Zhou, Xinyuan
Source:
Biomaterials science 2019 v.7 no.6 pp. 2533-2544
ISSN:
2047-4849
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; CD8-positive T-lymphocytes; cytotoxicity; immunotherapy; interleukin-2; nanoparticles; neoplasms; pathogens; reactive oxygen species; transcription factor NF-kappa B;     Show all 11 Subjects
Abstract:
... Cytotoxic CD8⁺ T cells (CTLs) are crucial for controlling intracellular pathogens as well as cancer. However, how to promote the cytotoxic activity of CTL cells in vitro and in vivo remains largely unknown. On the other hand, ceria nanoparticles (CNPs) are widely used in biomedical fields, but the role of CNPs in CTL cells is still unclear. In this study, we found that the activated antigen-specif ...
DOI:
10.1039/c9bm00113a

18. Experimental infection in mice with Erwinia persicina

Author:
Mohamaden, Walaa I.; Zhen-fen, Zhang; Hegab, Ibrahim M.; Shang-li, Shi
Source:
Microbial pathogenesis 2019 v.130 pp. 38-43
ISSN:
0882-4010
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; Erwinia persicina; adults; bacteria; blood; cyclophosphamide; diarrhea; human diseases; hyperemia; intestines; kidneys; liver; lungs; mice; mortality; necropsy; signs and symptoms (animals and humans);     Show all 18 Subjects
Abstract:
... Erwinia persicinus (E. persicina) is a plant pathogenic bacterial species that was previously isolated from a case of human infection. This study aimed to create an experimental infection protocol for E. persicina in laboratory mice. Seventy-two adult mice were divided into four groups (18 animal/group): the control group (G1), the group infected with E. persicina (G2), the group immune-suppressed ...
DOI:
10.1016/j.micpath.2019.01.050

19. The effects of dietary astaxanthin on intestinal health of juvenile tiger puffer Takifugu rubripes in terms of antioxidative status, inflammatory response and microbiota

Author:
Ou, Weihao; Liao, Zhangbin; Yu, Guijuan; Xu, Houguo; Liang, Mengqing; Mai, Kangsen; Zhang, Yanjiao
Source:
Aquaculture nutrition 2019 v.25 no.2 pp. 466-476
ISSN:
1353-5773
Subject:
necrosis; tumor necrosis factor-alpha,   etc   ; Arcobacter; Takifugu rubripes; astaxanthin; diet; enzyme activity; enzymes; gene expression regulation; hindgut; inflammation; interleukin-8; intestinal microorganisms; intestines; juveniles; malondialdehyde; neoplasms; transcription (genetics);     Show all 18 Subjects
Abstract:
... A 74‐day feeding trial was conducted to evaluate the effects of dietary astaxanthin (ASTX) on antioxidative status, inflammatory response and microbiota in the intestine of tiger puffer. Four diets differed only in ASTX content, that is, 0 (Control), 50 (ASTX50), 100 (ASTX100) and 500 (ASTX500) mg/kg. Compared with Control, ASTX50 and ASTX100 significantly reduced the malondialdehyde content and s ...
DOI:
10.1111/anu.12872

20. Viral infections in tilapines: More than just tilapia lake virus

Author:
Machimbirike, Vimbai Irene; Jansen, Mona Dverdal; Senapin, Saengchan; Khunrae, Pongsak; Rattanarojpong, Triwit; Dong, Ha Thanh
Source:
Aquaculture 2019 v.503 pp. 508-518
ISSN:
0044-8486
Subject:
Infectious pancreatic necrosis virus; Infectious spleen and kidney necrosis virus,   etc   ; Betanodavirus; Bohle iridovirus; Herpesviridae; Iridovirus; Lymphocystivirus; Tilapia lake virus; disease outbreaks; disease surveillance; mortality; pathogens; viruses;     Show all 13 Subjects
Abstract:
... There is an increasing number of emerging infectious agents, although not zoonotic, that affect farmed tilapines worldwide. Most recently, the emergence of a new virus, tilapia lake virus (TiLV), has diverted global attention to it while little or no research is being done on the other viruses of possible equal importance. These other viruses have reportedly been associated with relatively high mo ...
DOI:
10.1016/j.aquaculture.2019.01.036