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You searched for: Subject "neuroglia" Remove constraint Subject: "neuroglia"
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1. The role of neural stem cells in regulating glial scar formation and repair

Author:
Alexandra M. Nicaise; Andrea D’Angelo; Rosana-Bristena Ionescu; Grzegorz Krzak; Cory M. Willis; Stefano Pluchino
Source:
Cell and tissue research 2022 v.387 no.3 pp. 399-414
ISSN:
0302-766X
Subject:
neuroglia,   etc   ; central nervous system; inflammation; research;     Show all 4 Subjects
Abstract:
... Glial scars are a common pathological occurrence in a variety of central nervous system (CNS) diseases and injuries. They are caused after severe damage and consist of reactive glia that form a barrier around the damaged tissue that leads to a non-permissive microenvironment which prevents proper endogenous regeneration. While there are a number of therapies that are able to address some component ...
DOI:
10.1007/s00441-021-03554-0

2. Activation of the MAC1-ERK1/2-NOX2 Pathway Is Required for LPS-Induced Sustaining Reactive Microgliosis, Chronic Neuroinflammation and Neurodegeneration

Author:
Shih-Heng Chen; Shuangyu Han; Chih-Fen Hu; Ran Zhou; Yun Gao; Dezhen Tu; Huiming Gao; Jing Feng; Yubao Wang; Ru-Band Lu; Jau-Shyong Hong
Source:
Antioxidants 2022 v.11 no.6 pp. -
ISSN:
2076-3921
Subject:
neuroglia,   etc   ; neurodegenerative diseases; neurons; oxidative stress; phosphorylation;     Show all 5 Subjects
Abstract:
... Recent studies suggest that improper resolution of acute neuroinflammation may lead to long-lasting low-grade chronic neuroinflammation and drive progressive neurodegeneration. However, the molecular mechanism underlying the transition from acute to chronic neuroinflammation remains unclear. The main purpose of this study was to search for potential pathways mediating LPS-elicited chronic neuroinf ...
DOI:
10.3390/antiox11061202

3. Phenolic glycosides from Oroxylum indicum

Author:
Le Thi Vien; Tran Thi Hong Hanh; Tran Hong Quang; Nguyen The Cuong; Nguyen Xuan Cuong; Hyuncheol Oh; Nguyen Van Sinh; Nguyen Hoai Nam; Chau Van Minh
Source:
Natural product research 2022 v.36 no.9 pp. 2336-2340
ISSN:
1478-6427
Subject:
neuroglia,   etc   ; Oroxylum indicum; bark; cell lines; glycosides; research;     Show all 6 Subjects
Abstract:
... Two new phenolic glycosides, oroxylumosides A (1) and B (2), along with four known compounds darendoside A (3), leucosceptoside A (4), acteoside (5) and decaffeoylacteoside (6) were isolated from the stem bark of Oroxylum indicum. Their structures were elucidated by extensive analysis of the 1 D and 2 D NMR as well as HR-ESI-QTOF-MS. In addition, compounds 1 − 4 exhibited inhibitory effects on NO ...
DOI:
10.1080/14786419.2020.1834548

4. Silk fibroin hydrolysate improves memory impairment via multi-target function

Author:
Siyuan Yao; Zheng Xu; Song Chen; Yue Meng; Yue Xue; Wenbing Yao; Xiangdong Gao
Source:
Journal of functional foods 2022 v.89 pp. 104942
ISSN:
1756-4646
Subject:
neuroglia,   etc   ; fibroins; hydrolysates; memory; memory disorders; neurons; rats;     Show all 7 Subjects
Abstract:
... Previously we have reported a specific hydrolysate form of silk fibroin named SFH and in vitro beneficial effects of SFH on neuron, however, evidence in vivo for the specific neuroprotective function of SFH on AD is urgently needed and our understanding for mechanism underlying SFH function is far from completion. In this study, we report here the amelioration of neurodegenerative changes in Aβ₂₅₋ ...
DOI:
10.1016/j.jff.2022.104942

5. Gadolinium chloride protects neurons by regulating the activation of microglia in the model of optic nerve crush

Author:
Pengfei Yang; Li Wei; Huanbing Tian; Feifei Yu; Yongpeng Shi; Lan Gao
Source:
Biochemical and biophysical research communications 2022 v.618 pp. 119-126
ISSN:
0006-291X
Subject:
neuroglia,   etc   ; apoptosis; gadolinium; ganglia; inflammation; models; nerve tissue; research; retina; transcriptomics;     Show all 10 Subjects
Abstract:
... The pathological basis of optic nerve crush (ONC) is the apoptosis of retinal ganglion cells (RGCs), which leads to an irreversible impairment of visual function. When stimulated by external stimuli, microglia polarize into different types and play different roles in repairing retinal injury. In this study, gadolinium chloride (GdCl₃) could inhibit the excessive proliferation and activation of mic ...
DOI:
10.1016/j.bbrc.2022.05.088

6. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-ɑ/AKT/p70S6 kinase signaling

Author:
Jang-Hyuk Yun; Da-Hye Lee; Han-Seok Jeong; Seung-Hoon Kim; Sang-Kyu Ye; Chung-Hyun Cho
Source:
Biochemical and biophysical research communications 2022 v.613 pp. 133-139
ISSN:
0006-291X
Subject:
neuroglia,   etc   ; apoptosis; diabetic retinopathy; gene expression; inflammation; interleukin-6; research; therapeutics;     Show all 8 Subjects
Abstract:
... Diabetic retinopathy (DR) is one of the vascular complications associated with diabetes mellitus. Pericyte loss is an early characteristic phenomenon in DR. However, the mechanism by which pericyte apoptosis occurs in DR is not fully understood. We have focused on the increased STAT3 activation in diabetic retinas because STAT3 activation is associated with inflammation, and persistent chronic inf ...
DOI:
10.1016/j.bbrc.2022.05.004

7. The Microglial membrane receptor TREM2 mediates exosome secretion to promote phagocytosis of amyloid‐β by microglia

Author:
Si Huang; Xiaoli Liao; Junyong Wu; Xiaojie Zhang; Yamin Li; Daxiong Xiang; Shilin Luo
Source:
FEBS letters 2022 v.596 no.8 pp. 1059-1071
ISSN:
0014-5793
Subject:
neuroglia,   etc   ; Alzheimer disease; antigen presentation; central nervous system; exosomes; phagocytosis; secretion;     Show all 7 Subjects
Abstract:
... Considerable evidence links the microglial transmembrane receptor TREM2 to the progression of Alzheimer's disease through its involvement in Aβ phagocytosis by microglia. While previous studies have mainly focused on the phagocytic regulation of microglia itself, the antigen presentation of microglial exosomes in the process of immunity has been less investigated. Here, we identified TREM2 express ...
DOI:
10.1002/1873-3468.14336

8. Aβ-responsive metformin-based supramolecular synergistic nanodrugs for Alzheimer's disease via enhancing microglial Aβ clearance

Author:
Zhongxiong Fan; Tong Ren; Youjun Wang; Hao Jin; Dao Shi; Xiaofeng Tan; Dongtao Ge; Zhenqing Hou; Xin Jin; Lichao Yang
Source:
Biomaterials 2022 v.283 pp. 121452
ISSN:
0142-9612
Subject:
neuroglia,   etc   ; Alzheimer disease; biocompatible materials; blood-brain barrier; brain; metformin; phagocytosis; therapeutics;     Show all 8 Subjects
Abstract:
... Here, inspired by the concept of supramolecular inclusion complex, we successfully fabricate metformin (Met)-based supramolecular nanodrugs with the Aβ-responsive on-demand drug release for synergistic Alzheimer's disease (AD) therapy via enhancing microglial Aβ clearance. Interestingly, the introduction of low-dosage Met (1.1 mg/kg) can not only significantly improve the structural stability of n ...
DOI:
10.1016/j.biomaterials.2022.121452

9. Treadmill exercise improve recognition memory by TREM2 pathway to inhibit hippocampal microglial activation and neuroinflammation in Alzheimer's disease model

Author:
Linlin Zhang; Yanzhong Liu; Xin Wang; Dan Wang; Hao Wu; Haichun Chen; Jiaxin Chen; Yiping Liu
Source:
Physiology & behavior 2022 v.251 pp. 113820
ISSN:
0031-9384
Subject:
neuroglia,   etc   ; Alzheimer disease; Dependoparvovirus; behavior; cognition; disease models; exercise; memory disorders; phenotype;     Show all 9 Subjects
Abstract:
... Alzheimer's disease-related cognition impairment is correlated with increased neuroinflammation. Studies show that physical exercises improve cognitive function and regulate neuroinflammation. However, no sufficient studies have been performed to directly observe the mechanism of exercise-related effects on microglia and neuroinflammation, in association with memory function under Alzheimer's dise ...
DOI:
10.1016/j.physbeh.2022.113820

10. BoNT/A alleviates neuropathic pain in osteoarthritis by down-regulating the expression of P2X4R in spinal microglia

Author:
Hui Yang; Lin Wang; Xiao Chu; Xiaojuan Shi; Xinhe Li; Tieshan Li
Source:
Toxicon 2022 v.206 pp. 55-63
ISSN:
0041-0101
Subject:
neuroglia,   etc   ; Western blotting; analgesic effect; analgesics; asymmetry; betamethasone; immunohistochemistry; osteoarthritis; pain; spinal cord;     Show all 10 Subjects
Abstract:
... Neuropathic pain in osteoarthritis is one of the reasons why the pain is difficult to treat, and P2X4R plays an important role in neuropathic pain. In addition, BoNT/A has been proven to have analgesic effects on both neuropathic pain and osteoarthritis, but its exact mechanism is still unknown. This study aims to investigate the relationship between the analgesic effect of BoNT/A on osteoarthriti ...
DOI:
10.1016/j.toxicon.2021.12.012

11. Microglia in CNS infections: insights from Toxoplasma gondii and other pathogens

Author:
Maureen N. Cowan; Ish Sethi; Tajie H. Harris
Source:
Trends in parasitology 2022 v.38 no.3 pp. 217-229
ISSN:
1471-4922
Subject:
neuroglia,   etc   ; Protozoa; Toxoplasma gondii; animals; brain; homeostasis; immunopathology; inflammation; neurodegenerative diseases; neuropathology; parasitology;     Show all 11 Subjects
Abstract:
... Microglia, the resident immune cells of the central nervous system (CNS), are poised to respond to neuropathology. Microglia play multiple roles in maintaining homeostasis and promoting inflammation in numerous disease states. The study of microglial innate immune programs has largely focused on exploring neurodegenerative disease states with the use of genetic targeting approaches. Our understand ...
DOI:
10.1016/j.pt.2021.12.004

12. NaF-induced neurotoxicity via activation of the IL-1β/JNK signaling pathway

Author:
Chengzhi Zhang; Yanmei Yang; Yanhui Gao; Dianjun Sun
Source:
Toxicology 2022 v.469 pp. 153132
ISSN:
0300-483X
Subject:
neuroglia,   etc   ; antagonists; apoptosis; cognitive disorders; culture media; memory; neurons; neurotoxicity; phosphorylation; toxicology; viability;     Show all 11 Subjects
Abstract:
... Excessive fluoride exposure can induce neuron apoptosis that is associated with neurodegenerative changes, but the mechanisms remain elusive. It has been suggested that chronic fluoride-induced microglia activation contributes to neuronal damage by producing pro-inflammatory cytokines. IL-1β, a pro-inflammatory cytokine released by activated microglia, is capable of inducing JNK phosphorylation an ...
DOI:
10.1016/j.tox.2022.153132

13. A time-course study of microglial activation and dopaminergic neuron loss in the substantia nigra of mice with paraquat-induced Parkinson's disease

Author:
Hui-Ming Yang; Yong-Ling Wang; Chong-Yue Liu; Yu-Ting Zhou; Xiao-Feng Zhang
Source:
Food and chemical toxicology 2022 v.164 pp. 113018
ISSN:
0278-6915
Subject:
neuroglia,   etc   ; Parkinson disease; histopathology; interleukin-10; interleukin-6; males; neurons; paraquat; pathogenesis; phenotype; toxicology;     Show all 11 Subjects
Abstract:
... Activated microglia play an active role in the pathogenesis of PD and paraquat (PQ) induces PD. The study was to understand the time relationship between microglial activation and dopaminergic neuron loss in the substantia nigra (SN) of PQ-induced PD mice. Male C57BL/6 mice were injected intraperitoneally with PQ, twice a week for six weeks. Some mice underwent behavioral assessments each week and ...
DOI:
10.1016/j.fct.2022.113018

14. JEV infection increases USP42 to stabilize TRIM21 and OAS1 for neuroinflammatory and anti-viral response in human microglia

Author:
Ritu Mishra; Kanhaiya Lal Kumawat; Anirban Basu; Akhil C. Banerjea
Source:
Virology 2022 pp. -
ISSN:
0042-6822
Subject:
neuroglia,   etc   ; Japanese encephalitis virus; death; encephalitis; humans; mosquito-borne diseases; neurons; ubiquitin; virology; viruses;     Show all 10 Subjects
Abstract:
... Japanese Encephalitis Virus (JEV), a member virus of Flaviviridae family causes Japanese encephalitis (JE). JE is a mosquito-borne disease, spread mainly by Culexspp. During JE, dysregulated inflammatory responses play a central role in neuronal death and damage leading to Neuroinflammation. In this study, we show that JEV infection in human microglial cells (CHME3) reduces the cellular miR-590-3p ...
DOI:
10.1016/j.virol.2022.06.012

15. Anti-neuroinflammatory effect of oxaline, isorhodoptilometrin, and 5-hydroxy-7-(2′-hydroxypropyl)-2-methyl-chromone obtained from the marine fungal strain Penicillium oxalicum CLC-MF05

Author:
Dong-Cheol Kim; Tran Hong Quang; Nguyen Thuy Tien; Kwan-Woo Kim; Youn-Chul Kim; Nguyen Thi Thanh Ngan; Nguyen Xuan Cuong; Nguyen Hoai Nam; Hyuncheol Oh
Source:
Archives of pharmacal research 2022 v.45 no.2 pp. 90-104
ISSN:
0253-6269
Subject:
neuroglia,   etc   ; Penicillium oxalicum; cytotoxicity; fermentation; fungi; interleukin-12; interleukin-6; phenolic compounds; research; secondary metabolites;     Show all 10 Subjects
Abstract:
... Penicillium is a rich source of bioactive compounds. Among all Penicillium species, Penicillium oxalicum has been reported to produce various types of secondary metabolites, including alkaloids, phenolics, and tetrahydroxanthone dimeric compounds, exhibiting many pharmacological effects, such as antiviral, antibacterial, and cytotoxic activities. Three secondary metabolites were isolated from a fe ...
DOI:
10.1007/s12272-022-01370-w

16. Citicoline–liposome/polyurethane composite scaffolds regulate the inflammatory response of microglia to promote nerve regeneration

Author:
Jingjing Lin; Xingying Song; Hang Yin; Nijia Song; Yanchao Wang; Zhen Li; Feng Luo; Hong Tan; Xueling He; Jiehua Li
Source:
Journal of materials science 2022 v.57 no.3 pp. 2073-2088
ISSN:
0022-2461
Subject:
neuroglia,   etc   ; axons; blood-brain barrier; central nervous system; drugs; inflammation; nerve regeneration; nerve tissue; polyurethanes;     Show all 9 Subjects
Abstract:
... Regulating the immune microenvironment around the central neurons is a difficult problem. To address this critical matter, drug-loading scaffolds are promising ways of releasing drugs directly to the surrounding cells and ignoring the influence of blood–brain barrier and blood–medullary barrier. Microglia are fundamental innate immune sentinels in the central nervous system, usually activated duri ...
DOI:
10.1007/s10853-021-06628-0

17. Natural Products as Novel Neuroprotective Agents; Computational Predictions of the Molecular Targets, ADME Properties, and Safety Profile

Author:
Sahar Saleh Alghamdi; Rasha Saad Suliman; Norah Abdulaziz Aljammaz; Khawla Mohammed Kahtani; Dimah Abdulqader Aljatli; Ghadeer M. Albadrani
Source:
Plants 2022 v.11 no.4 pp. -
ISSN:
2223-7747
Subject:
neuroglia,   etc   ; absorption; anti-inflammatory activity; blood-brain barrier; lipophilicity; metabolites; molecular weight; phytochemicals; public health;     Show all 9 Subjects
Abstract:
... Neurodegenerative diseases (NDs) are one of the most challenging public health issues. Despite tremendous advances in our understanding of NDs, little progress has been made in establishing effective treatments. Natural products may have enormous potential in preventing and treating NDs by targeting microglia; yet, there have been several clinical concerns about their usage, primarily due to a lac ...
DOI:
10.3390/plants11040549

18. Coculture of ARPE-19 Cells and Porcine Neural Retina as an Ex Vivo Retinal Model

Author:
Natalie Wagner; Armin Safaei; Pia A. Vogt; Maurice R. Gammel; H. Burkhard Dick; Sven Schnichels; Stephanie C. Joachim
Source:
ATLA. Alternatives to laboratory animals v.50 no.1 pp. 27-44
ISSN:
0261-1929
Subject:
neuroglia,   etc   ; coculture; complement; death; epithelium; ex vivo studies; glutamic acid; humans; laboratories; models; photoreceptors; retina; swine;     Show all 13 Subjects
Abstract:
... Neural retinal organ cultures are used to investigate ocular pathomechanisms. However, these cultures lack the essential retinal pigment epithelium (RPE) cells, which are part of the actual in vivo retina. To simulate a more realistic ex vivo model, porcine neural retina explants were cocultured with ARPE-19 cells (ARPE-19 group), which are derived from human RPE. To identify whether the entire ce ...
DOI:
10.1177/02611929221082662

19. Microglial integrin, chemokine receptors, and inflammatory response vary with development

Author:
Yan Chen; Hengrui Zhang; Yu Zhao; Ye Zhang; Saige Yin; Yan Hu; Guolan Ma; Di Lu; Jun Sun
Source:
Biochemical and biophysical research communications 2022 v.615 pp. 94-101
ISSN:
0006-291X
Subject:
neuroglia,   etc   ; adulthood; adults; central nervous system; chemokine receptors; chemokines; complement; inflammation; integrins; perinatal period; phenotype; research;     Show all 12 Subjects
Abstract:
... Understanding microglia development could improve our understanding of the central nervous system (CNS) and neurological diseases. To explore the immune phenotypic changes that occur in microglia during development, we studied the morphology, inflammatory response, and expression of several important immune-related proteins in normal microglia from the embryonic, neonatal (postnatal day 3), and ad ...
DOI:
10.1016/j.bbrc.2022.05.054

20. Minor terpenoids from the stems and twigs of Rhododendron ovatum

Author:
Min Ma; Ya-Nan Wang; Hai-Qiang Wang; Shuang-Gang Ma; Yong Li; Jing Qu; Shi-Shan Yu
Source:
Journal of Asian natural products research 2022 v.24 no.5 pp. 445-456
ISSN:
1477-2213
Subject:
neuroglia,   etc   ; Rhododendron; circular dichroism spectroscopy; colorectal neoplasms; cytotoxicity; humans; monoterpenoids; neoplasm cells; nitric oxide; research; triterpenoids;     Show all 11 Subjects
Abstract:
... Four minor undescribed terpenoids, including a monoterpenoid (1) and three triterpenoids (3, 6 and 7), together with 26 known terpenoids were isolated from the stems and twigs of Rhododendron Ovatum. Their structures were identified by extensive spectroscopic analyses and electronic circular dichroism (ECD) techniques. Compound 10 showed excellent cytotoxicity against human colon cancer cell (HCT- ...
DOI:
10.1080/10286020.2022.2027916