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1. Functional, proteomic and transcriptomic characterization of the venom from Micrurus browni browni: Identification of the first lethal multimeric neurotoxin in coral snake venom

Author:
Bénard-Valle, Melisa; Neri-Castro, Edgar; Yañez-Mendoza, Manuel F.; Lomonte, Bruno; Olvera, Alejandro; Zamudio, Fernando; Restano-Cassulini, Rita; Possani, Lourival D.; Jiménez-Ferrer, Enrique; Alagón, Alejandro
Source:
Journal of proteomics 2020 v.225 pp. 103863
ISSN:
1874-3919
Subject:
neurotoxicity,   etc   ; Micrurus; messenger RNA; mice; neurotoxins; organobromine compounds; phospholipases; proteome; proteomics; snake venoms; snakes; transcriptome; transcriptomics;     Show all 13 Subjects
Abstract:
... Proteomic characterization of Micrurus browni browni venom showed approximately 41 components belonging to 9 protein families, mainly phospholipases A₂ (PLA₂s) and three-finger toxins (3FTxs). Venom gland transcriptome yielded 39 venom transcripts belonging to 10 protein families. Functional characterization identified a multimeric toxin, here designated Brownitoxin-1, which comprises at least one ...
DOI:
10.1016/j.jprot.2020.103863

2. 5-HT2A receptor-mediated PKCδ phosphorylation is critical for serotonergic impairments induced by p-chloroamphetamine in mice

Author:
Phan, Dieu Hien; Shin, Eun-Joo; Sharma, Naveen; Hoang Yen, Tran Phi; Dang, Duy-Khanh; Lee, Yong Sup; Lee, Yu Jeung; Nah, Seung-Yeol; Cheong, Jae Hoon; Jeong, Ji Hoon; Kim, Hyoung-Chun
Source:
Food and chemical toxicology 2020 v.141 pp. 111395
ISSN:
0278-6915
Subject:
neurotoxicity,   etc   ; amphetamine; antagonists; enzyme inhibitors; gene expression; genes; mice; phosphorylation; protein kinase C; toxicology;     Show all 10 Subjects
Abstract:
... p-Chloroamphetamine (PCA), an amphetamine derivative, has been shown to induce serotonergic toxicity. However, the precise mechanism of serotonergic toxicity induced by PCA remains unclear. In this study, PCA treatment (20 mg/kg, i.p.) did not significantly change 5-HT₁A receptor gene expression, but significantly increased 5-HT₂A receptor gene expression. Furthermore, 5-HT₂A receptor antagonist M ...
DOI:
10.1016/j.fct.2020.111395

3. Neuro-protection of Chlorogenic acid against Al-induced apoptosis in PC12 cells via modulation of Al metabolism and Akt/GSK-3β pathway

Author:
Cheng, Dai; Wang, Guangliang; Wang, Xuerui; Tang, Jinlei; Yu, Qianqian; Zhang, Xinyu; Wang, Shuo
Source:
Journal of functional foods 2020 v.70 pp. 103984
ISSN:
1756-4646
Subject:
neurotoxicity,   etc   ; aluminum; aluminum chloride; apoptosis; chlorogenic acid; metabolism; polyphenols; protective effect; signal transduction;     Show all 9 Subjects
Abstract:
... Dietary polyphenols showed good scavenging effects on the neurotoxicity of aluminum (Al). The aim of this study was to explore the mechanism of CGA on AlCl₃ in PC12 cells. Based on the protective effect of CGA on the apoptosis of PC12 cells induced by AlCl₃, we designed a scheme of intervention with CGA before, during and after AlCl₃ treatment. The results showed that the co-treatment of CGA and A ...
DOI:
10.1016/j.jff.2020.103984

4. Impacts of nanoplastics on bivalve: Fluorescence tracing of organ accumulation, oxidative stress and damage

Author:
Li, Zhenling; Feng, Chenghong; Wu, Yuehan; Guo, Xiaoyu
Source:
Journal of hazardous materials 2020 v.392 pp. 122418
ISSN:
0304-3894
Subject:
neurotoxicity,   etc   ; Bivalvia; benthic organisms; fluorescence; gills; inflammation; intestines; liver; nanoplastics; oral exposure; oxidative stress; polystyrenes; stomach;     Show all 13 Subjects
Abstract:
... The outcomes of this research offer novel insights into the toxic effects of nanoparticles (i.e., nanoplastics or other nanomaterials) on the benthos. Herein, this study aimed to evaluate the accumulation pathway, distribution characteristics and potential biotoxicity of polystyrene nanoplastics in C. fluminea. The results revealed that nanoplastics could accumulate in the mantle through adherence ...
DOI:
10.1016/j.jhazmat.2020.122418

5. Periphery-confined particulate systems for the management of neurodegenerative diseases and toxicity: Avoiding the blood-brain-barrier challenge

Author:
Rabanel, Jean-Michel; Delbreil, Philippe; Banquy, Xavier; Brambilla, Davide; Ramassamy, Charles
Source:
Journal of controlled release 2020 v.322 pp. 286-299
ISSN:
0168-3659
Subject:
neurotoxicity,   etc   ; blood-brain barrier; brain; drugs; endothelium; hydrophilicity; neurodegenerative diseases; proteins; therapeutics;     Show all 9 Subjects
Abstract:
... The blood-brain barrier prevents passage of large and hydrophilic molecules, undermining efforts to deliver most active molecules, proteins and other macromolecules. To date, nanoparticle-assisted delivery has been extensively studied to overcome this challenge but with limited success. On the other hand, for certain brain therapeutic applications, periphery-confined particles could be of immediat ...
DOI:
10.1016/j.jconrel.2020.03.035

6. Effect of pristine fullerene on acquisition, consolidation and retrieval memory in wistar rats

Author:
Santa-Helena, Eduarda; Seus, Natália; Castro, Micheli
Source:
Comparative biochemistry and physiology 2020 v.232 pp. 108740
ISSN:
1532-0456
Subject:
neurotoxicity,   etc   ; antioxidant activity; fullerene; hippocampus; lipid peroxidation; memory; oxidative stress; rats; reactive oxygen species;     Show all 9 Subjects
Abstract:
... The present study evaluated the effect of fullerene (C₆₀) under in vitro conditions, in hippocampus homogenates from rats and on the induction of behavioral disabilities. Exposure to in vitro C₆₀ led to an increase in the concentration of reactive oxygen species (ROS) and lipid peroxidation (LPO) of hippocampus treated with of fullerene and suspension. These results indicate that the oxidative str ...
DOI:
10.1016/j.cbpc.2020.108740

7. Comparative neuroprotective effects of native curcumin and its galactomannoside formulation in carbofuran-induced neurotoxicity model

Author:
E. R., Sindhu; P. P., Binitha; Nair, Saritha S.; Maliakel, Balu; Kuttan, Ramadasan; I. M., Krishnakumar
Source:
Natural product research 2020 v.34 no.10 pp. 1456-1460
ISSN:
1478-6427
Subject:
neurotoxicity,   etc   ; bioavailability; brain; carbofuran; curcumin; histopathology; liver; mitochondria; models; neuroprotective effect; oxidative stress; pain; rats;     Show all 13 Subjects
Abstract:
... Toxicity of the pesticide carbofuran (CF) can be alleviated by curcumin, if not for its poor bioavailability. Hence, we investigated the effect of a bioavailable curcumin-galactomannan complex (CGM) on CF-induced neurotoxicity in rats in comparison to that of unformulated standard curcumin (CS). The CF (5 mg/kg b.wt/day) treatment for 90 days produced chronicity model which were treated with eithe ...
DOI:
10.1080/14786419.2018.1514401

8. Development of AOP relevant to microplastics based on toxicity mechanisms of chemical additives using ToxCast™ and deep learning models combined approach

Author:
Jeong, Jaeseong; Choi, Jinhee
Source:
Environment international 2020 v.137 pp. 105557
ISSN:
0160-4120
Subject:
neurotoxicity,   etc   ; additives; adverse outcome pathways; databases; durability; genes; inflammation; lipid metabolism; microplastics; neoplasms; neural networks; pollution;     Show all 12 Subjects
Abstract:
... Various additives are used in plastic products to improve the properties and the durability of the plastics. Their possible elution from the plastics when plastics are fragmented into micro- and nano-size in the environment is suspected to one of the major contributors to environmental and human toxicity of microplastics. In this context, to better understand the hazardous effect of microplastics, ...
DOI:
10.1016/j.envint.2020.105557

9. α₃β₁ Integrin-Targeting Polymersomal Docetaxel as an Advanced Nanotherapeutic for Nonsmall Cell Lung Cancer Treatment

Author:
Zou, Yan; Sun, Yinping; Guo, Beibei; Wei, Yaohua; Xia, Yifeng; Huangfu, Zhenyuan; Meng, Fenghua; van Hest, Jan C. M.; Yuan, Jiandong; Zhong, Zhiyuan
Source:
ACS applied materials & interfaces 2020 v.12 no.13 pp. 14905-14913
ISSN:
1944-8252
Subject:
neurotoxicity,   etc   ; adverse effects; antineoplastic activity; cytotoxicity; human diseases; integrins; lung neoplasms; mice; neoplasm cells; patients;     Show all 10 Subjects
Abstract:
... Docetaxel (DTX) widely used for treating nonsmall cell lung cancer (NSCLC) patients is associated with dose-limiting side effects, especially neurotoxicity and myelosuppression. Here, we have developed cyclic cNGQGEQc peptide-directed polymersomal docetaxel (cNGQ-PS-DTX) as a targeted and multifunctional formulation for NSCLC. cNGQ-PS-DTX carrying 8.1 wt % DTX had a size of 93 nm, neutral surface ...
DOI:
10.1021/acsami.0c01069

10. Toxicity comparison between pristine and sulfonate modified nanopolystyrene particles in affecting locomotion behavior, sensory perception, and neuronal development in Caenorhabditis elegans

Author:
Qu, Man; Wang, Dayong
Source:
The Science of the total environment 2020 v.703 pp. 134817
ISSN:
0048-9697
Subject:
neurotoxicity,   etc   ; Caenorhabditis elegans; chemotaxis; diacetyl; fluorescence; head; locomotion; neurons; polystyrenes; sensation; sodium chloride; sulfonates;     Show all 12 Subjects
Abstract:
... Sulfonate modified polystyrene is potentially used in medical application; however, the effect of sulfonate modification on polystyrene toxicity is still largely unclear. We here compared the neurotoxicity between pristine and sulfonate modified nanopolystyrene particles in nematode Caenorhabditis elegans. Exposure to nanopolystyrene (35 nm) caused neurotoxicity on locomotion behaviors (head thras ...
DOI:
10.1016/j.scitotenv.2019.134817

11. Stability of Aβ11–40 Trimers with Parallel and Antiparallel β-Sheet Organizations in a Membrane-Mimicking Environment by Replica Exchange Molecular Dynamics Simulation

Author:
Ngo, Son Tung; Nguyen, Phuong H.; Derreumaux, Philippe
Source:
TheJournal of physical chemistry 2020 v.124 no.4 pp. 617-626
ISSN:
1520-5207
Subject:
neurotoxicity,   etc   ; Alzheimer disease; amino acids; amyloid; brain; models; molecular dynamics; mutants; mutation; patients; peptides;     Show all 11 Subjects
Abstract:
... The aggregation of the amyloid (Aβ) peptide of 39–43 amino acids into plaques is observed in the brain of Alzheimer’s disease (AD) patients, but the mechanisms underlying the neurotoxicity of Aβ oligomers are still elusive. One suggested initial mechanism is related to the implications of amyloid membrane interactions, but characterization of these assemblies is challenging by experimental means. ...
DOI:
10.1021/acs.jpcb.9b10982

12. Manganese modifies Neurotrophin-3 (NT3) and its tropomyosin receptor kinase C (TrkC) in the cortex: Implications for manganese-induced neurotoxicity

Author:
Yang, Yiping; Wei, Fu; Wang, Jian; Chen, Rui; Zhang, Jie; Li, Danni; Gan, Dong; Yang, Xiaobo; Zou, Yunfeng
Source:
Food and chemical toxicology 2020 v.135 pp. 110925
ISSN:
0278-6915
Subject:
neurotoxicity,   etc   ; apoptosis; caspase-3; cortex; ligands; manganese; mitogen-activated protein kinase; neurons; signal transduction; tropomyosins;     Show all 10 Subjects
Abstract:
... Manganese (Mn), an essential micronutrient, has the potential to induce apoptosis. The NT3/TrkC ligand/receptor pair known as part of the classic neurotrophic theory plays a critical role in neuronal survival. However, whether the NT3/TrkC-mediated signaling pathways are involved in Mn-induced apoptosis of cortical neurons remains unknown. The present study was designed to investigate the interact ...
DOI:
10.1016/j.fct.2019.110925

13. Total Synthesis of Hoiamide A Using an Evans–Tishchenko Reaction as a Key Step

Author:
Guo, Yian; Zhou, Jingjing; Gao, Bowen; Zhao, Meng; Yan, Jia-Lei; Xu, Zhengshuang; Choi, Sun; Ye, Tao
Source:
Organic letters 2019 v.21 no.14 pp. 5471-5474
ISSN:
1523-7052
Subject:
neurotoxicity,   etc   ; aldehydes; chemical reactions; chemical structure; threonine;     Show all 5 Subjects
Abstract:
... The first total synthesis of neurotoxic cyclodepsipeptide hoiamide A (1) has been accomplished. The synthesis features the use of an Evans–Tishchenko fragment coupling between a five-stereogenic-center-containing β-hydroxyketone and a chiral aldehyde derived from threonine. ...
DOI:
10.1021/acs.orglett.9b01735

14. The why and how of micro(nano)plastic research

Author:
Oliveira, M.; Almeida, M.
Source:
Trends in analytical chemistry 2019 v.114 pp. 196-201
ISSN:
0165-9936
Subject:
neurotoxicity,   etc   ; energy; metabolism; nanoplastics; pollution; risk;     Show all 6 Subjects
Abstract:
... The presence of small plastic particles in the environment, reported for the first time in the 1970's, has only recently been recognized as a global issue. Although environmental awareness continues to grow, so does its consumption and associated risks. The number of studies reporting the presence of microplastics, has grown exponentially as did the concern over plastic degradation into smaller pa ...
DOI:
10.1016/j.trac.2019.02.023

15. An unusual case of gross myoglobinuria in a child following Russell's viper (Daboia russelii) envenomation

Author:
Dissanayake, P.V.; Muthukumarana, T.G.W.; Aslam, W.A.M.; Chaminda, S.A.A.; Munasinghe, T.S.; Kularatne, S.A.M.
Source:
Toxicon 2019 v.157 pp. 77-79
ISSN:
0041-0101
Subject:
neurotoxicity,   etc   ; Daboia russelii; children; nephrotoxicity; snakes;     Show all 5 Subjects
Abstract:
... Overt myoglobinuria associated with myotoxicity is a classic feature of sea snake envenomation. Russell's viper bites usually result in coagulopathy, neurotoxicity and nephrotoxicity but rarely myotoxicity has been reported, especially in the Sri Lankan variety (Daboia russelii). All those studies have demonstrated mild degree myotoxicity with microscopic level myoglobinuria. We report what is pro ...
DOI:
10.1016/j.toxicon.2018.11.299

16. Behavioural toxicity of environmental relevant concentrations of a glyphosate commercial formulation - RoundUp® UltraMax - During zebrafish embryogenesis

Author:
Lanzarin, Germano A.B.; Venâncio, Carlos A.S.; Monteiro, Sandra M.; Félix, Luís M.
Source:
Chemosphere 2020 v.253 pp. 126636
ISSN:
0045-6535
Subject:
neurotoxicity,   etc   ; Danio rerio; active ingredients; adverse effects; cortisol; ecosystems; embryo (animal); embryogenesis; environmental exposure; glyphosate; larvae; social behavior; soil; wildlife;     Show all 14 Subjects
Abstract:
... The use of herbicides with glyphosate as an active ingredient (a.i.) has increased dramatically in recent years, with its residues often being found in either soil or water. Nevertheless, concerns have arisen about its harmful side effects for both ecosystems and wildlife health. Therefore, the objective of this work was to assess the effects of a commercial formulation of glyphosate (RoundUp® Ult ...
DOI:
10.1016/j.chemosphere.2020.126636

17. Combined exposure of lead and cadmium leads to the aggravated neurotoxicity through regulating the expression of histone deacetylase 2

Author:
Zhou, Ruiqing; Zhao, Jing; Li, Danyang; Chen, Yao; Xiao, Yanyan; Fan, Anni; Chen, Xiang-Tao; Wang, Hui-Li
Source:
Chemosphere 2020 v.252 pp. 126589
ISSN:
0045-6535
Subject:
neurotoxicity,   etc   ; cadmium; central nervous system; epigenetics; heavy metals; histone deacetylase; laboratory animals; lead; memory; neurites; rats; staining;     Show all 12 Subjects
Abstract:
... Lead (Pb) and cadmium (Cd) are common heavy metals in the environment, exerting detrimental effects on central nervous system. Although increasing evidence demonstrated the Pb and Cd-induced neurotoxicity, the exact epigenetic mechanisms induced by combined exposure (co-exposure) of Pb and Cd are still unclear. In this study, the neurotoxicity of individual exposure and co-exposure to Pb and Cd in ...
DOI:
10.1016/j.chemosphere.2020.126589

18. Neurotoxicity of perfluorooctanoic acid and post-exposure recovery due to blueberry anthocyanins in the planarians Dugesia japonica

Author:
Zhang, Jianyong; Shao, Xinxin; Zhao, Baoying; Zhai, Liming; Liu, Na; Gong, Fangbin; Ma, Xue; Pan, Xiaolu; Zhao, Bosheng; Yuan, Zuoqing; Zhang, Xiufang
Source:
Environmental pollution 2020 v.263 pp. 114471
ISSN:
0269-7491
Subject:
neurotoxicity,   etc   ; DNA damage; Dugesia; acetylcholinesterase; anthocyanins; blueberries; comet assay; ecosystems; enzyme activity; locomotion; neurons; neurotoxins; neurotransmitters; perfluorooctanoic acid;     Show all 14 Subjects
Abstract:
... Perfluorooctanoic acid (PFOA) is a widely used synthetic industrial chemical which accumulates in ecosystems and organisms. Our study have investigated the neurobehavioral effects of PFOA and the alleviation effects of PFOA-induced neurotoxicity by blueberry anthocyanins (ANT) in Dugesia japonica. The planarians were exposed to PFOA and ANT for ten days. Researchs showed that exposure to PFOA affe ...
DOI:
10.1016/j.envpol.2020.114471

19. Both N-Terminal and C-Terminal Histidine Residues of the Prion Protein Are Essential for Copper Coordination and Neuroprotective Self-Regulation

Author:
Schilling, Kevin M.; Tao, Lizhi; Wu, Bei; Kiblen, Joseph T.M.; Ubilla-Rodriguez, Natalia C.; Pushie, M. Jake; Britt, R. David; Roseman, Graham P.; Harris, David A.; Millhauser, Glenn L.
Source:
Journal of molecular biology 2020 v.432 no.16 pp. 4408-4425
ISSN:
0022-2836
Subject:
neurotoxicity,   etc   ; amino acid sequences; antibodies; copper; cultured cells; histidine; humans; mutants; mutation; prion diseases; prions; protective effect;     Show all 12 Subjects
Abstract:
... The cellular prion protein (PrPC) comprises two domains: a globular C-terminal domain and an unstructured N-terminal domain. Recently, copper has been observed to drive tertiary contact in PrPC, inducing a neuroprotective cis interaction that structurally links the protein's two domains. The location of this interaction on the C terminus overlaps with the sites of human pathogenic mutations and to ...
DOI:
10.1016/j.jmb.2020.05.020

20. Calreticulin regulated intrinsic apoptosis through mitochondria-dependent and independent pathways mediated by ER stress in arsenite exposed HT-22 cells

Author:
Wang, Xiaotong; Liu, Xudan; Chen, Yao; Wang, Huanhuan; Zhang, Ruo; Zhang, Qianhui; Wei, Yuting; Shi, Sainan; Li, Xin
Source:
Chemosphere 2020 v.251 pp. 126466
ISSN:
0045-6535
Subject:
neurotoxicity,   etc   ; apoptosis; arsenic; arsenites; calreticulin; caspase-3; cell lines; chronic exposure; dose response; endoplasmic reticulum; mice; quality control; signal transduction;     Show all 13 Subjects
Abstract:
... Arsenic is a naturally occurring environmental toxicant. Chronic exposure to arsenic is linked with neurological damage. Although the mechanisms remain to be elucidated, it is currently believed that neural cell apoptosis is one of the underlying mechanisms of arsenic-induced neurotoxicity. Calreticulin (CRT) is a quality control chaperone located in the lumen of the endoplasmic reticulum (ER), wh ...
DOI:
10.1016/j.chemosphere.2020.126466