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1. Retraction: Elevation of USP4 antagonizes oxygen glucose deprivation/reoxygenation-evoked microglia activation and neuroinflammation-mediated neurotoxicity via the TRAF6-NF-κB signaling

Author:
Fisher, Laura
Source:
RSC advances 2021 v.11 no.8 pp. 4374
ISSN:
2046-2069
Subject:
neurotoxicity,   etc   ; glucose; neuroglia; oxygen;     Show all 4 Subjects
Abstract:
... Retraction of ‘Elevation of USP4 antagonizes oxygen glucose deprivation/reoxygenation-evoked microglia activation and neuroinflammation-mediated neurotoxicity via the TRAF6-NF-κB signaling’ by Zhaoxia Wang, RSC Adv., 2019, 9, 23916–23924, DOI: 10.1039/C9RA03614H. ...
DOI:
10.1039/d1ra90021h

2. Vlasoulides A and B, a pair of neuroprotective C₃₂ dimeric sesquiterpenes with a hexacyclic 5/7/5/5/(5)/7 carbon skeleton from the roots of Vladimiria souliei

Author:
Wu, Zhi-li; Wang, Qun; Fu, Lu; Su, Ri-xin; Sun, Ze-shi; Li, Hui-liang
Source:
RSC advances 2021 v.11 no.11 pp. 6159-6162
ISSN:
2046-2069
Subject:
neurotoxicity,   etc   ; carbon; sesquiterpenoids; spectral analysis;     Show all 4 Subjects
Abstract:
... Vlasoulides A and B (1 and 2), a pair of epimeric C₃₂ sesquiterpene lactone dimers, featuring a 5/7/5/5/(5)/7 ring system were isolated from the roots of Vladimiria souliei. Their chemical structures were determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D NMR spectroscopic data. Their absolute configurations were established by Mosher's method and ECD exper ...
DOI:
10.1039/d1ra00075f

3. NeurotoxKb 1.0: Compilation, curation and exploration of a knowledgebase of environmental neurotoxicants specific to mammals

Author:
Ravichandran, Janani; Karthikeyan, Bagavathy Shanmugam; Singla, Palak; Aparna, S.R.; Samal, Areejit
Source:
Chemosphere 2021 v.278 pp. 130387
ISSN:
0045-6535
Subject:
neurotoxicity,   etc   ; exposome; humans; nervous system; neurotoxins; toxicology;     Show all 6 Subjects
Abstract:
... Exposure to environmental neurotoxicants is a significant concern due to their potential to cause permanent or irreversible damage to the human nervous system. Here, we present the first dedicated knowledgebase, NeurotoxKb 1.0, on environmental neurotoxicants specific to mammals. Using a detailed workflow, we have compiled 475 potential non-biogenic neurotoxicants from 835 published studies with e ...
DOI:
10.1016/j.chemosphere.2021.130387

4. Binding of Cu2+ to Aβ1-29 causes aggregation and toxicity in SH-SY5Y cells

Author:
Taniguchi, Masanari; Saito, Mayu; Kuga, Takahisa; Yamagishi, Nobuyuki
Source:
Biochemical and biophysical research communications 2021 v.534 pp. 617-623
ISSN:
0006-291X
Subject:
neurotoxicity,   etc   ; apoptosis; cytotoxicity; digestion; pathogenesis; peptides; research;     Show all 7 Subjects
Abstract:
... The accumulation and aggregation of amyloid-β (Aβ) are critical factors in the pathogenesis of Alzheimer’s disease (AD). Several studies have indicated that metal ions such as Cu²⁺and Zn²⁺ play a key role in the formation and stabilization of neurotoxic Aβ aggregates, however the molecular mechanisms underlying Aβ cytotoxicity have not yet been fully elucidated. Previously, we showed that the Aβ-d ...
DOI:
10.1016/j.bbrc.2020.11.031

5. Proteostasis-associated aging: lessons from a Drosophila model

Author:
Yu, Garbin; Hyun, Seogang
Source:
Genes & genomics 2021 v.43 no.1 pp. 1-9
ISSN:
1976-9571
Subject:
neurotoxicity,   etc   ; Drosophila; autophagy; genomics; homeostasis; longevity; models;     Show all 7 Subjects
Abstract:
... As cells age, they lose their ability to properly fold proteins, maintain protein folding, and eliminate misfolded proteins, which leads to the accumulation of abnormal protein aggregates and loss of protein homeostasis (proteostasis). Loss of proteostasis can accelerate aging and the onset of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Mechanisms exist to preve ...
DOI:
10.1007/s13258-020-01012-9

6. Comment on “Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity” Antioxidants 2020, 9, 594

Author:
Stehr, Jan Eric; Lundström, Ingemar; Karlsson, Jan Olof G.
Source:
Antioxidants 2020 v.9 no.9
ISSN:
2076-3921
Subject:
neurotoxicity,   etc   ; antioxidants; nerve fibers;     Show all 3 Subjects
Abstract:
... We have with enthusiasm read the article “Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity” written by Annalisa Canta, Guido Cavaletti and co-workers and published in Antioxidants [...] ...
DOI:
10.3390/antiox9090802

7. Structural Characterization of Individual α-Synuclein Oligomers Formed at Different Stages of Protein Aggregation by Atomic Force Microscopy-Infrared Spectroscopy

Author:
Zhou, Lei; Kurouski, Dmitry
Source:
Analytical chemistry 2020 v.92 no.10 pp. 6806-6810
ISSN:
1520-6882
Subject:
neurotoxicity,   etc   ; analytical chemistry; spectroscopy;     Show all 3 Subjects
Abstract:
... Aberrant α-synuclein aggregation is strongly associated with the onset and development of Parkinson’s disease (PD). Therefore, characterizing the structure of toxic intermediate oligomers plays an essential role in better understanding their neurotoxicity. Using atomic force microscopy-infrared spectroscopy (AFM-IR), we were able to reveal the structure of α-synuclein oligomers present at differen ...
DOI:
10.1021/acs.analchem.0c00593

8. Clusterin overexpression as a potential neuroprotective response to the pathological effects of high fat dieting on the brain reward system

Author:
Rodríguez-Rivera, Carmen; Pérez-Ortiz, José Manuel; Pook, Elizabeth; Conjaerts, Nina; Alguacil, Luis F.; González-Martín, Carmen
Source:
Food and chemical toxicology 2021 v.152 pp. 112186
ISSN:
0278-6915
Subject:
neurotoxicity,   etc   ; brain; cortex; extinction; immunochemistry; males; sucrose; toxicology;     Show all 8 Subjects
Abstract:
... High-fat diets (HFDs) can lead to pathological changes in the brain underlying several behavioral disturbances (e.g., reward deficiency). To further increase our knowledge of these associations, we studied the sucrose reward and the brain expression of clusterin, a protein that is overexpressed after several kind of brain damaging conditions. C57BL/6J male mice were differentially fed on an HFD or ...
DOI:
10.1016/j.fct.2021.112186

9. Previously unrecognized potential threat to children from manganese in groundwater in rohingya refugee camps in Cox’s Bazar, Bangladesh

Author:
Rahman, M. Feisal; Mahmud, Md Juel; Sadmani, A.H.M. Anwar; Chowdhury, Ahmed I.; Anderson, William B.; Bodruzzaman, Abu B.M.; Huq, Saleemul
Source:
Chemosphere 2021 v.266 pp. 129128
ISSN:
0045-6535
Subject:
neurotoxicity,   etc   ; epidemiological studies; groundwater; manganese; neurodevelopment; neurotoxins; risk; Bangladesh; Myanmar;     Show all 9 Subjects
Abstract:
... The forced displacement of over 700,000 Rohingyas from Myanmar to Bangladesh since the crackdown in August 2017 has resulted in a critical humanitarian and environmental crisis. Groundwater is the primary source of drinking water in the camps that were constructed to provide shelter for the refugee population. The current study explores occurrence of Mn in groundwater in the Rohingya camps and adj ...
DOI:
10.1016/j.chemosphere.2020.129128

10. Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity

Author:
Maity, Debabrata; Howarth, Madeline; Vogel, Maria C.; Magzoub, Mazin; Hamilton, Andrew D.
Source:
Journal of the American Chemical Society 2021 v.143 no.8 pp. 3086-3093
ISSN:
1520-5126
Subject:
neurotoxicity,   etc   ; amyloid; biocompatibility; cytotoxicity; homeostasis; humans; hydrophilicity; hydrophobicity; mice; mitochondria;     Show all 10 Subjects
Abstract:
... An interruption in Aβ homeostasis leads to the deposit of neurotoxic amyloid plaques and is associated with Alzheimer’s disease. A supramolecular strategy based on the assembly of peptidomimetic agents into functional vesicles has been conceived for the simultaneous inhibition of Aβ₄₂ fibrillation and expedited clearance of Aβ₄₂ aggregates. Tris-pyrrolamide peptidomimetic, ADH-353, contains one hy ...
DOI:
10.1021/jacs.0c09967

11. Crotalus Neutralizing Factor (CNF) inhibits the toxic effects of Crotoxin at mouse neuromuscular preparations

Author:
Pinto, Êmylle Karoline Ramos; Souza, Natália Muradas Valério; Maciel, Fernanda Valadares; de Abreu, Thales Augusto Gonçalves; Reis, Henrique Freitas Ferreira; Ortolani, Paula Ladeira; Fortes-Dias, Consuelo Latorre; Cavalcante, Walter Luís Garrido
Source:
Toxicon 2021 v.191 pp. 48-53
ISSN:
0041-0101
Subject:
neurotoxicity,   etc   ; ; Crotalus durissus terrificus; diaphragm; histology; mice; myotoxicity; phospholipases; venoms;     Show all 9 Subjects
Abstract:
... Crotalus Neutralizing Factor (CNF) was the first phospholipase A₂ inhibitor isolated from the plasma of the South American rattlesnake (Crotalus durissus terrificus). Previous biochemical and biophysical studies demonstrate an interaction of CNF with Crotoxin (CTX), the main toxic component in the venom of these snakes. CTX promotes the blockade of neuromuscular transmission by a sum of neurotoxic ...
DOI:
10.1016/j.toxicon.2020.12.016

12. l- Proline as a Valuable Scaffold for the Synthesis of Novel Enantiopure Neonicotinoids Analogs

Author:
Bonilla-Landa, Israel; Cuapio-Muñoz, Ulises; Luna-Hernández, Axel; Reyes-Luna, Alfonso; Rodríguez-Hernández, Alfredo; Ibarra-Juarez, Arturo; Suarez-Mendez, Gabriel; Barrera-Méndez, Felipe; Caram-Salas, Nadia; Enríquez-Medrano, J. Francisco; Díaz de León, Ramón E.; Olivares-Romero, José Luis
Source:
Journal of agricultural and food chemistry 2021 v.69 no.5 pp. 1455-1465
ISSN:
1520-5118
Subject:
neurotoxicity,   etc   ; Xyleborus; dinotefuran; enantiomers; food chemistry; insecticidal properties; lead; proline;     Show all 8 Subjects
Abstract:
... In this research, six neonicotinoid analogs derived from l-proline were synthesized, characterized, and evaluated as insecticides against Xyleborus affinis. Most of the target compounds showed good to excellent insecticidal activity. To the best of our knowledge, this is the first report dealing with the use of enantiopure l-proline to get neonicotinoids. These results highlighted the compound 9 a ...
DOI:
10.1021/acs.jafc.0c05997

13. Exposure to lead and cadmium of the Belgian consumers from ceramic food contact articles

Author:
Li, Yan; Zhang, Jianqing
Source:
Toxicology reports 2021 v.8 pp. 548-556
ISSN:
2214-7500
Subject:
neurotoxicity,   etc   ; cadmium; ceramics; food safety; lead; nephrotoxicity; risk; toxicology;     Show all 8 Subjects
Abstract:
... This study was aimed at estimating the intake of lead and cadmium by the Belgian consumers due to the use of ceramic ware. We adopted refined exposure scenarios with respect to migrant concentration, ceramic ware usage, and metal release characteristics. A deterministic estimation was initially performed, followed by probabilistic estimation, if the deterministic estimate exceeds toxicological ref ...
DOI:
10.1016/j.toxrep.2021.02.015

14. Synthesis of (−)-Picrotoxinin by Late-Stage Strong Bond Activation

Author:
Crossley, Steven W. M.; Tong, Guanghu; Lambrecht, Michael J.; Burdge, Hannah E.; Shenvi, Ryan A.
Source:
Journal of the American Chemical Society 2020 v.142 no.26 pp. 11376-11381
ISSN:
1520-5126
Subject:
neurotoxicity,   etc   ; sesquiterpenoids; stereoselective synthesis; stereoselectivity;     Show all 4 Subjects
Abstract:
... We report a concise, stereocontrolled synthesis of the neurotoxic sesquiterpenoid (−)-picrotoxinin (1, PXN). The brevity of the route is due to regio- and stereoselective formation of the [4.3.0] bicyclic core by incorporation of a symmetrizing geminal dimethyl group at C5. Dimethylation then enables selective C–O bond formation in multiple intermediates. A series of strong bond (C–C and C–H) clea ...
DOI:
10.1021/jacs.0c05042

15. Botulinum neurotoxin inhibitor binding dynamics and kinetics relevant for drug design

Author:
Patel, Kruti B.; Kononova, Olga; Cai, Shuowei; Barsegov, Valeri; Parmar, Virinder S.; Kumar, Raj; Singh, Bal Ram
Source:
Biochimica et biophysica acta 2021 v.1865 no.9 pp. 129933
ISSN:
0304-4165
Subject:
neurotoxicity,   etc   ; ; botulinum toxin; botulism; calorimetry; drug design; enzyme inhibition; fluorescence emission spectroscopy; molecular dynamics; psoralen; zinc;     Show all 11 Subjects
Abstract:
... A natural product analog, 3-(4-nitrophenyl)-7H-furo[3,2-g]chromen-7-one, which is a nitrophenyl psoralen (NPP) was found to be an effective inhibitor of botulinum neurotoxin type A (BoNT/A).In this work, we performed enzyme inhibition kinetics and employed biochemical techniques such as isothermal calorimetry (ITC) and fluorescence spectroscopy as well as molecular modeling to examine the kinetics ...
DOI:
10.1016/j.bbagen.2021.129933

16. Chlorpyrifos pesticide promotes oxidative stress and increases inflammatory states in BV-2 microglial cells: A role in neuroinflammation

Author:
Cezimbra Weis, Grazielle Castagna; Weis, Grazielle Castagna Cezimbra; Assmann, Charles Elias; Mostardeiro, Vitor Bastianello; Alves, Audrei de Oliveira; da Rosa, Jéssica Righi; Pillat, Micheli Mainardi; de Andrade, Cinthia Melazzo; Schetinger, Maria Rosa Chitolina; Morsch, Vera Maria Melchiors; da Cruz, Ivana Beatrice Mânica; Costabeber, Ijoni Hilda
Source:
Chemosphere 2021 v.278 pp. 130417
ISSN:
0045-6535
Subject:
neurotoxicity,   etc   ; blood-brain barrier; brain; cell cycle checkpoints; chlorpyrifos; interphase; mice; oxidative stress;     Show all 8 Subjects
Abstract:
... The exposure to environmental stressors, such as organophosphate (OP) pesticides, has been associated with the development of neurodegenerative diseases. Chlorpyrifos (CPF) is the worldwide most used OP pesticide and one of the most hazardous pesticides as it can cross the blood-brain barrier. Since studies evaluating the effects of CPF on brain immune cells are scarce, this research investigated ...
DOI:
10.1016/j.chemosphere.2021.130417

17. Environmentally relevant concentrations of microplastics influence the locomotor activity of aquatic biota

Author:
Sun, Tao; Zhan, Junfei; Li, Fei; Ji, Chenglong; Wu, Huifeng
Source:
Journal of hazardous materials 2021 v.414 pp. 125581
ISSN:
0304-3894
Subject:
neurotoxicity,   etc   ; dysbiosis; energy; freshwater; inflammation; intestinal microorganisms; locomotion; meta-analysis; metabolic diseases; microplastics; oxidative stress;     Show all 11 Subjects
Abstract:
... The occurrence of microplastics (MPs) in various marine and freshwater matrices has attracted great attention. However, the effect of MPs in natural environment on the locomotor performance of aquatic biota is still controversial. Therefore, this meta-analysis was conducted, involving 116 effect sizes from 2347 samples, to quantitatively evaluate the alteration in locomotor behavior of aquatic org ...
DOI:
10.1016/j.jhazmat.2021.125581

18. Toxic effects on bioaccumulation, hematological parameters, oxidative stress, immune responses and neurotoxicity in fish exposed to microplastics: A review

Author:
Kim, Jun-Hwan; Yu, Young-Bin; Choi, Jae-Ho
Source:
Journal of hazardous materials 2021 v.413 pp. 125423
ISSN:
0304-3894
Subject:
neurotoxicity,   etc   ; antioxidant activity; aquatic environment; bioaccumulation; biomarkers; blood; fish; microplastics; oxidative stress; physiology; reactive oxygen species;     Show all 11 Subjects
Abstract:
... Exposure to microplastics (MP) in aquatic environment leads to bioaccumulation in fish, with MP size being a major factor in determining the accumulation profile. MPs absorbed into the fish body enter the circulatory system and affect hematological properties, changing the blood physiology. MPs also induce an imbalance in reactive oxygen species (ROS) production and antioxidant capacity, causing o ...
DOI:
10.1016/j.jhazmat.2021.125423

19. Engineered expression of the invertebrate‐specific scorpion toxin AaHIT reduces adult longevity and female fecundity in the diamondback moth Plutella xylostella

Author:
Harvey‐Samuel, Tim; Xu, Xuejiao; Lovett, Erica; Dafa'alla, Tarig; Walker, Adam; Norman, Victoria C; Carter, Ruth; Teal, Joss; Akilan, Luxziyah; Leftwich, Philip T; Reitmayer, Christine M; Siddiqui, Hamid A; Alphey, Luke
Source:
Pest management science 2021 v.77 no.7 pp. 3154-3164
ISSN:
1526-498X
Subject:
neurotoxicity,   etc   ; ; Plutella xylostella; Scorpiones; adults; antidotes; fecundity; females; genomics; longevity; pest management; phenotype; tetracycline; toxins; transgenes;     Show all 15 Subjects
Abstract:
... BACKGROUND: Previous genetic pest management (GPM) systems in diamondback moth (DBM) have relied on expressing lethal proteins (‘effectors’) that are ‘cell‐autonomous’, that is, they do not leave the cell in which they are expressed. To increase the flexibility of future GPM systems in DBM, we aimed to assess the use of a non‐cell‐autonomous, invertebrate‐specific, neurotoxic effector – the scorpi ...
DOI:
10.1002/ps.6353

20. Behavioural effects in mice orally exposed to domoic acid or ibotenic acid are influenced by developmental stages and sex differences

Author:
Sasaki, Takahiro; Saito, Hirokatsu; Hiradate, Yuuki; Hara, Kenshiro; Tanemura, Kentaro
Source:
Biochemical and biophysical research communications 2021 v.558 pp. 175-182
ISSN:
0006-291X
Subject:
neurotoxicity,   etc   ; brain; domoic acid; females; glutamic acid; males; memory; neurotoxins; neurotransmitters; research; risk; sexual maturity;     Show all 12 Subjects
Abstract:
... The structure of the brain is dramatically altered during the critical period. Physiological substances (neurotransmitters, hormones, etc.) in the body fluctuate significantly before and after sexual maturation. Therefore, the effect of chemical exposure on the central nervous system often differs depending on the developmental stage and sex. We aimed to compare the behavioural effects that emerge ...
DOI:
10.1016/j.bbrc.2021.04.080