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You searched for: Subject "neurotoxicity" Remove constraint Subject: "neurotoxicity"
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1. The regulatory roles of DDIT4 in TDCIPP-induced autophagy and apoptosis in PC12 cells

Author:
Li Li; Lingyi Xi; Jin Wu; Zunquan Zhao; Youliang Chen; Weili Liu; Zhihui Pan; Mingzhu Liu; Danfeng Yang; Zhaoli Chen; Yanjun Fang
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 823-830
ISSN:
1001-0742
Subject:
neurotoxicity,   etc   ; DNA; Western blotting; apoptosis; autophagy; flame retardants; flow cytometry; humans; neurons; phosphates; phosphorylation; protective effect; rats; China;     Show all 14 Subjects
Abstract:
... Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is a commonly used organophosphate-based flame retardant and can bio-accumulate in human tissues and organs. As its structure is similar to that of neurotoxic organophosphate pesticides, the neurotoxicity of TDCIPP has raised widespread concerns. TDCIPP can increase neuronal apoptosis and induce autophagy. However, its regulatory mechanism remains un ...
DOI:
10.1016/j.jes.2022.02.046

2. Assessment of risks, implications, and opportunities of waterborne neurotoxic pesticides

Author:
Delaram Dara; Andrei P. Drabovich
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 735-741
ISSN:
1001-0742
Subject:
neurotoxicity,   etc   ; bioaccumulation; biochemical compounds; biodegradation; bioremediation; chlorinated hydrocarbons; genetic engineering; humans; mice; nervous system; organophosphorus compounds; pyrethrins; synergism; therapeutics; viability; China;     Show all 16 Subjects
Abstract:
... Pesticides are a well-known family of chemicals that have contaminated water systems globally. Four common subfamilies of pesticides include organochlorines, organophosphates, pyrethroids, and carbamate insecticides which have been shown to adversely affect the human nervous system. Studies have shown a link between pesticide exposure and decreased viability, proliferation, migration, and differen ...
DOI:
10.1016/j.jes.2022.03.033

3. Contagious Aggregation: Transmittable Protein Aggregation in Cellular Communities Initiated by Synthetic Cells

Author:
Hong-Guen Lee; Jin Hae Kim; Tumpa Gorai; Young Ho Ko; Haw-Young Kwon; Wooseong Chung; Ilha Hwang; Sungsu Lim; Yun Kyung Kim; Kwanwoo Shin; Young-Tae Chang; Kimoon Kim; Kyeng Min Park
Source:
Journal of the American Chemical Society 2022 v.144 no.11 pp. 5067-5073
ISSN:
1520-5126
Subject:
neurotoxicity,   etc   ; artificial cells; lipids;     Show all 3 Subjects
Abstract:
... Aggregation of amyloidogenic proteins causing neurodegenerative diseases is an uncontrollable and contagious process that is often associated with lipid membranes in a highly complex physiological environment. Although several approaches using natural cells and membrane models have been reported, systematic investigations focusing on the association with the membranes are highly challenging, mostl ...
DOI:
10.1021/jacs.1c13545

4. Is a cure for Parkinson’s disease hiding inside us?

Author:
Jaime Santos; Irantzu Pallarès; Salvador Ventura
Source:
Trends in biochemical sciences 2022 pp. -
ISSN:
0968-0004
Subject:
neurotoxicity,   etc   ; amyloid; peptides; surfactants; therapeutics;     Show all 5 Subjects
Abstract:
... α-Synuclein (a-syn) oligomers and fibrils are behind neurodegeneration in Parkinson’s disease (PD), but therapeutically targeting them is challenging. Amphipathic and cationic helical peptides inhibit amyloid formation and suppress neurotoxicity by selectively binding the solvent-accessible regions in these toxic species. Can endogenous peptides, like LL-37, constitute a new therapeutic paradigm i ...
DOI:
10.1016/j.tibs.2022.02.001

5. Protection against Amyloid-β Oligomer Neurotoxicity by Small Molecules with Antioxidative Properties: Potential for the Prevention of Alzheimer’s Disease Dementia

Author:
Wataru Araki; Fuyuki Kametani
Source:
Antioxidants 2022 v.11 no.1 pp. -
ISSN:
2076-3921
Subject:
neurotoxicity,   etc   ; amyloid; drugs; oxidative stress; therapeutics;     Show all 5 Subjects
Abstract:
... Soluble oligomeric assemblies of amyloid β-protein (Aβ), called Aβ oligomers (AβOs), have been recognized as primary pathogenetic factors in the molecular pathology of Alzheimer’s disease (AD). AβOs exert neurotoxicity and synaptotoxicity and play a critical role in the pathological progression of AD by aggravating oxidative and synaptic disturbances and tau abnormalities. As such, they are import ...
DOI:
10.3390/antiox11010132

6. Pharmacokinetics and Time above the MIC Exposure of Cefepime in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation (ECMO)

Author:
Abigail K. Kois; Jason A. Gluck; David P. Nicolau; Joseph L. Kuti
Source:
International journal of antimicrobial agents 2022 v.60 no.1 pp. 106603
ISSN:
0924-8579
Subject:
neurotoxicity,   etc   ; models; patients; pharmacodynamics; pharmacokinetics; renal clearance;     Show all 6 Subjects
Abstract:
... This study determined the pharmacokinetics of cefepime in patients requiring extracorporeal membrane oxygenation (ECMO) support to guide dosage selection. Cefepime population pharmacokinetics where characterized in Pmetrics for R for six critically ill patients receiving ECMO. Simulation was employed to determine the fT>MIC and total trough concentration of varying regimens in each patient to eval ...
DOI:
10.1016/j.ijantimicag.2022.106603

7. Physical Mechanism of Amyloid-β Peptide Chain Aggregation on Fluidic Lipid Nanotubules

Author:
Yu Geng; Tingting Huang; Wu Zhou; Lei Shen
Source:
Langmuir 2022 v.38 no.18 pp. 5752-5758
ISSN:
1520-5827
Subject:
neurotoxicity,   etc   ; lipids; models; nanotubes; nanowires; peptides; synapse;     Show all 7 Subjects
Abstract:
... The question of how peptide chain aggregation is influenced by lipid membranes with varying shapes and structures is crucial for a detailed understanding of the neurotoxicity effect of the peptide chains. Not like the more usual spherical liposomes and planar lipid membranes, herein, we use lipid nanotubules as a model of important neuron synapse nanowire structures and devote particular attention ...
DOI:
10.1021/acs.langmuir.2c00357

8. TFEB ameliorates autophagy flux disturbance induced by PBDE-47 via up-regulating autophagy-lysosome fusion

Author:
Huayang Tang; Haoying Huang; Dan Wang; Pei Li; Zhiyuan Tian; Dongjie Li; Sumei Wang; Rulin Ma; Tao Xia; Aiguo Wang
Source:
Journal of hazardous materials 2022 v.430 pp. 128483
ISSN:
0304-3894
Subject:
neurotoxicity,   etc   ; autophagosomes; autophagy; biogenesis; flame retardants; lysosomes;     Show all 6 Subjects
Abstract:
... 2,2′,4,4′-tetrabromodiphenyl ether (PBDE-47), the widely used brominated flame retardant, has remarkable neurotoxicity which is associated with autophagy disorder. However, the mechanism remains unclear. The results showed that PBDE-47 damaged lysosomal biogenesis and interfered with autophagy-lysosome fusion both in vivo and in vitro. Our investigation further demonstrated that PBDE-47 could down ...
DOI:
10.1016/j.jhazmat.2022.128483

9. Proximate causes and ultimate effects of common antidepressants, fluoxetine and venlafaxine, on fish behavior

Author:
Arash Salahinejad; Anoosha Attaran; Denis Meuthen; Douglas P. Chivers; Som Niyogi
Source:
Science of the total environment 2022 v.807 pp. 150846
ISSN:
0048-9697
Subject:
neurotoxicity,   etc   ; antidepressants; anxiety; environment; fish behavior; fluoxetine; wastewater;     Show all 7 Subjects
Abstract:
... Antidepressant (AD) drugs are widely prescribed for the treatment of psychiatric disorders, including depression and anxiety disorders. The continuous use of ADs causes significant quantities of these bioactive chemicals to enter the aquatic ecosystems mainly through wastewater effluent discharge. This may result in many aquatic organisms being inadvertently affected by these drugs. Fluoxetine (FL ...
DOI:
10.1016/j.scitotenv.2021.150846

10. Aptamer-Induced-Dimerization Strategy Attenuates AβO Toxicity through Modulating the Trophic Activity of PrPC Signaling

Author:
Shuya Liu; Shiwei Li; Jirong Lin; Jingying Li; Huanghao Yang
Source:
Journal of the American Chemical Society 2022 v.144 no.21 pp. 9264-9270
ISSN:
1520-5126
Subject:
neurotoxicity,   etc   ; amyloid; apoptosis; cytokines; dimerization; mitochondria; prions; secretion; therapeutics;     Show all 9 Subjects
Abstract:
... Current therapeutic strategies for Alzheimer’s disease (AD) mainly focus on amyloid β oligomer (AβO) formation or clearance. However, most of them have failed to yield good clinical results. There is an urgent need to explore an alternative therapeutic target for AD treatments. Recent studies have indicated that the cellular prion protein (PrPC) is one of the cell-surface receptors of AβO that med ...
DOI:
10.1021/jacs.2c00287

11. Neurotoxic or neuroprotective: Post-translational modifications of α-synuclein at the cross-roads of functions

Author:
Joshna Gadhavi; Mohini Patel; Dhiraj Bhatia; Sharad Gupta
Source:
Biochimie 2022 v.192 pp. 38-50
ISSN:
0300-9084
Subject:
neurotoxicity,   etc   ; Parkinson disease; brain stem; cerebral cortex; neurites; therapeutics;     Show all 6 Subjects
Abstract:
... Parkinson's disease is the second most prevalent neurodegenerative disease. The loss of dopaminergic neurons in the substantia nigra is one of the pathological hallmarks of PD. PD also belongs to the class of neurodegenerative disease known as ‘Synucleinopathies’ as α-synuclein is responsible for disease development. The presence of aggregated α-synuclein associated with other proteins found in th ...
DOI:
10.1016/j.biochi.2021.09.012

12. Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic

Author:
Ryan Limbocker; Silvia Errico; Denise Barbut; Tuomas P. J. Knowles; Michele Vendruscolo; Fabrizio Chiti; Michael Zasloff
Source:
Natural product reports 2022 v.39 no.4 pp. 742-753
ISSN:
1460-4752
Subject:
neurotoxicity,   etc   ; Alzheimer disease; animal models; brain; etiology; physical chemistry;     Show all 6 Subjects
Abstract:
... Alzheimer's and Parkinson's diseases are neurodegenerative conditions affecting over 50 million people worldwide. Since these disorders are still largely intractable pharmacologically, discovering effective treatments is of great urgency and importance. These conditions are characteristically associated with the aberrant deposition of proteinaceous aggregates in the brain, and with the formation o ...
DOI:
10.1039/d1np00042j

13. Soil heavy metal pollution from Pb/Zn smelting regions in China and the remediation potential of biomineralization

Author:
Xinghua Luo; Chuan Wu; Yongcheng Lin; Waichin Li; Min Deng; Jingqiang Tan; Shengguo Xue
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 662-677
ISSN:
1001-0742
Subject:
neurotoxicity,   etc   ; biomineralization; carcinogenicity; genotoxicity; heavy metals; remediation; soil pollution; China;     Show all 8 Subjects
Abstract:
... Smelting activities pose serious environmental problems due to the local and regional heavy metal pollution in soils they cause. It is therefore important to understand the pollution situation and its source in the contaminated soils. In this paper, data on heavy metal pollution in soils resulting from Pb/Zn smelting (published in the last 10 years) in China was summarized. The heavy metal polluti ...
DOI:
10.1016/j.jes.2022.01.029

14. Brain‐specific functions of the endocytic machinery

Author:
Santiago Camblor‐Perujo; Natalia L. Kononenko
Source:
FEBS journal 2022 v.289 no.8 pp. 2219-2246
ISSN:
1742-464X
Subject:
neurotoxicity,   etc   ; brain; endocytosis; lysosomes; neurons; neuroplasticity; nutrient uptake; plasma membrane;     Show all 8 Subjects
Abstract:
... Endocytosis is an essential cellular process required for multiple physiological functions, including communication with the extracellular environment, nutrient uptake, and signaling by the cell surface receptors. In a broad sense, endocytosis is accomplished through either constitutive or ligand‐induced invagination of the plasma membrane, which results in the formation of the plasma membrane‐ret ...
DOI:
10.1111/febs.15897

15. La voie tryptophane/kynurénine : un lien inédit entre obésité, chirurgie bariatrique et perception orosensorielle des lipides

Author:
Arnaud Bernard; Cédric Le May; Aurélie Dastugue; Audrey Ayer; Claire Blanchard; Jean-Charles Martin; Jean-Paul Pais de Barros; Pascaline Delaby; Cindy Le Bourgot; Séverine Ledoux; Philippe Besnard
Source:
Cahiers de nutrition et de diététique 2022 v.57 no.2 pp. 148-155
ISSN:
0007-9960
Subject:
neurotoxicity,   etc   ; bariatric surgery; kynurenine; lipids; metabolome; nutrition; obesity; taste; tryptophan;     Show all 9 Subjects
Abstract:
... Diet-induced obesity (DIO) reduces the orosensory perception of lipids in rodents and in some humans. Although bariatric surgery partially corrects this alteration, underlying mechanisms remain poorly understood. To explore whether metabolic changes might explain this fat taste disturbance, plasma metabolome analyses, two-bottle choice tests and fungiform papillae (Fun) counting were performed in ...
DOI:
10.1016/j.cnd.2022.01.002

16. Multi-walled carbon nanotubes impact on the enantioselective bioaccumulation and toxicity of the chiral insecticide bifenthrin to zebrafish (Danio rerio)

Author:
Tingting Zhao; Bo Ren; Yuexing Zhao; Haiyue Chen; Ju Wang; Yanhong Li; Hanlin Liang; Li Li; Hongwu Liang
Source:
Chemosphere 2022 v.294 pp. 133690
ISSN:
0045-6535
Subject:
neurotoxicity,   etc   ; Danio rerio; bifenthrin; bioaccumulation; carbon nanotubes; enantiomers; enantioselectivity; immunity;     Show all 8 Subjects
Abstract:
... The effects of different multi-walled carbon nanotubes on the enantioselective bioaccumulation and toxicity of the chiral pesticide bifenthrin to zebrafish were investigated in this work. The results showed that MWCNTs and MWCNTs-COOH did not affect the preferential bioaccumulation of 1R-cis-BF in zebrafish following exposure to cis-BF enantiomers for 28 days, but which increased cis-BF accumulati ...
DOI:
10.1016/j.chemosphere.2022.133690

17. Apoptosis, rather than neurogenesis, induces significant hippocampal‐dependent learning and memory impairment in chronic low Cd2+ exposure

Author:
Tianpeng Li; Shuyan Dong; Chengjian He; Jing Yang; Weiyun Li; Shanshan Li; Jing Li; Xiaoxue Du; Zhaoxia Hou; Luping Li; Songtao Li; Zhihui Huang; Tingting Sun
Source:
Environmental toxicology 2022 v.37 no.4 pp. 814-824
ISSN:
1520-4081
Subject:
neurotoxicity,   etc   ; apoptosis; autophagy; dose response; ecotoxicology; heavy metals; memory disorders; neurogenesis;     Show all 8 Subjects
Abstract:
... Cadmium (Cd), a ubiquitous toxic heavy metal, with the intractable trait of low degradation, can induce multiple organ damage. Whereas, far less is known about its neurotoxicity and the specific mechanism in the chronic low Cd exposure. To investigate the chronic neurotoxicity of Cd²⁺, we traced its effects for up to 30 months in mice which were exposed to Cd²⁺ by drinking the mimicking Cd‐pollute ...
DOI:
10.1002/tox.23445

18. Does Resveratrol Prevent Sevoflurane Toxicity in Newborn Rats?

Author:
Ayşenur Sümer Coşkun; Hatice Aslı Bedel; Mustafa Munzuroğlu; Narin Derin; Coşkun Usta
Source:
Journal of medicinal food 2022 v.25 no.5 pp. 557-563
ISSN:
1557-7600
Subject:
neurotoxicity,   etc   ; Western blotting; anesthesia; breathing; functional foods; memory; neonates; resveratrol; sevoflurane;     Show all 9 Subjects
Abstract:
... Inhalation anesthetics have been shown to cause neurodevelopmental disorders and neurotoxic effects. In this study, we aimed to investigate the effect of resveratrol on the possible neurotoxic effect of sevoflurane and the brain-derived neurotrophic factor (BDNF) pathway in newborn rats. The animals were divided into four groups: control, sevoflurane, sevoflurane+resveratrol 25 mg/kg, and sevoflur ...
DOI:
10.1089/jmf.2021.0154

19. Maternal DBP exposure promotes synaptic formation in offspring by activating astrocytes via the AKT/NF-κB/IL-6/JAK2/STAT3 signaling pathway

Author:
Yunhui Xia; Junhan Chen; Tan Ma; Xiannan Meng; Xiaodong Han; Dongmei Li
Source:
Science of the total environment 2022 v.829 pp. 154437
ISSN:
0048-9697
Subject:
neurotoxicity,   etc   ; astrocytes; corn oil; dibutyl phthalate; environment; hypothalamus; neurodevelopment; protein synthesis;     Show all 8 Subjects
Abstract:
... It has been demonstrated that activated astrocytes in the hypothalamus could disrupt GnRH secretion in offspring after maternal di-n-butyl phthalate (DBP) exposure, indicating that the effect of DBP on astrocyte activation and crosstalk between astrocytes and neurons is still worthy of further investigation. In this study, pregnant mice were intragastrically administered DBP dissolved in corn oil ...
DOI:
10.1016/j.scitotenv.2022.154437

20. The association of prenatal and childhood pyrethroid pesticide exposure with school-age ADHD traits

Author:
Kyung-Shin Lee; Youn-Hee Lim; Young Ah Lee; Choong Ho Shin; Bung-Nyun Kim; Yun-Chul Hong; Johanna Inhyang Kim
Source:
Environment international 2022 v.161 pp. 107124
ISSN:
0160-4120
Subject:
neurotoxicity,   etc   ; childhood; confidence interval; environment; metabolites; neurodevelopment; pregnancy; prenatal development; pyrethrins;     Show all 9 Subjects
Abstract:
... Pyrethroid insecticides are commonly used in residential settings, and their use has increased rapidly. Although research has been scarce, they have been reported to be associated with impaired neurodevelopment. Moreover, susceptible exposure windows and the long-term effects of pyrethroids have not been investigated. We examined the association between pyrethroid exposure and attention-deficit/hy ...
DOI:
10.1016/j.envint.2022.107124