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neurotoxicity, etc ; DNA; Western blotting; apoptosis; autophagy; flame retardants; flow cytometry; humans; neurons; phosphates; phosphorylation; protective effect; rats; China; Show all 14 Subjects
Abstract:
... Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is a commonly used organophosphate-based flame retardant and can bio-accumulate in human tissues and organs. As its structure is similar to that of neurotoxic organophosphate pesticides, the neurotoxicity of TDCIPP has raised widespread concerns. TDCIPP can increase neuronal apoptosis and induce autophagy. However, its regulatory mechanism remains un ...
... Pesticides are a well-known family of chemicals that have contaminated water systems globally. Four common subfamilies of pesticides include organochlorines, organophosphates, pyrethroids, and carbamate insecticides which have been shown to adversely affect the human nervous system. Studies have shown a link between pesticide exposure and decreased viability, proliferation, migration, and differen ...
Hong-Guen Lee; Jin Hae Kim; Tumpa Gorai; Young Ho Ko; Haw-Young Kwon; Wooseong Chung; Ilha Hwang; Sungsu Lim; Yun Kyung Kim; Kwanwoo Shin; Young-Tae Chang; Kimoon Kim; Kyeng Min Park
... Aggregation of amyloidogenic proteins causing neurodegenerative diseases is an uncontrollable and contagious process that is often associated with lipid membranes in a highly complex physiological environment. Although several approaches using natural cells and membrane models have been reported, systematic investigations focusing on the association with the membranes are highly challenging, mostl ...
neurotoxicity, etc ; amyloid; peptides; surfactants; therapeutics; Show all 5 Subjects
Abstract:
... α-Synuclein (a-syn) oligomers and fibrils are behind neurodegeneration in Parkinson’s disease (PD), but therapeutically targeting them is challenging. Amphipathic and cationic helical peptides inhibit amyloid formation and suppress neurotoxicity by selectively binding the solvent-accessible regions in these toxic species. Can endogenous peptides, like LL-37, constitute a new therapeutic paradigm i ...
neurotoxicity, etc ; amyloid; drugs; oxidative stress; therapeutics; Show all 5 Subjects
Abstract:
... Soluble oligomeric assemblies of amyloid β-protein (Aβ), called Aβ oligomers (AβOs), have been recognized as primary pathogenetic factors in the molecular pathology of Alzheimer’s disease (AD). AβOs exert neurotoxicity and synaptotoxicity and play a critical role in the pathological progression of AD by aggravating oxidative and synaptic disturbances and tau abnormalities. As such, they are import ...
neurotoxicity, etc ; models; patients; pharmacodynamics; pharmacokinetics; renal clearance; Show all 6 Subjects
Abstract:
... This study determined the pharmacokinetics of cefepime in patients requiring extracorporeal membrane oxygenation (ECMO) support to guide dosage selection. Cefepime population pharmacokinetics where characterized in Pmetrics for R for six critically ill patients receiving ECMO. Simulation was employed to determine the fT>MIC and total trough concentration of varying regimens in each patient to eval ...
neurotoxicity, etc ; lipids; models; nanotubes; nanowires; peptides; synapse; Show all 7 Subjects
Abstract:
... The question of how peptide chain aggregation is influenced by lipid membranes with varying shapes and structures is crucial for a detailed understanding of the neurotoxicity effect of the peptide chains. Not like the more usual spherical liposomes and planar lipid membranes, herein, we use lipid nanotubules as a model of important neuron synapse nanowire structures and devote particular attention ...
neurotoxicity, etc ; autophagosomes; autophagy; biogenesis; flame retardants; lysosomes; Show all 6 Subjects
Abstract:
... 2,2′,4,4′-tetrabromodiphenyl ether (PBDE-47), the widely used brominated flame retardant, has remarkable neurotoxicity which is associated with autophagy disorder. However, the mechanism remains unclear. The results showed that PBDE-47 damaged lysosomal biogenesis and interfered with autophagy-lysosome fusion both in vivo and in vitro. Our investigation further demonstrated that PBDE-47 could down ...
neurotoxicity, etc ; antidepressants; anxiety; environment; fish behavior; fluoxetine; wastewater; Show all 7 Subjects
Abstract:
... Antidepressant (AD) drugs are widely prescribed for the treatment of psychiatric disorders, including depression and anxiety disorders. The continuous use of ADs causes significant quantities of these bioactive chemicals to enter the aquatic ecosystems mainly through wastewater effluent discharge. This may result in many aquatic organisms being inadvertently affected by these drugs. Fluoxetine (FL ...
neurotoxicity, etc ; amyloid; apoptosis; cytokines; dimerization; mitochondria; prions; secretion; therapeutics; Show all 9 Subjects
Abstract:
... Current therapeutic strategies for Alzheimer’s disease (AD) mainly focus on amyloid β oligomer (AβO) formation or clearance. However, most of them have failed to yield good clinical results. There is an urgent need to explore an alternative therapeutic target for AD treatments. Recent studies have indicated that the cellular prion protein (PrPC) is one of the cell-surface receptors of AβO that med ...
neurotoxicity, etc ; Parkinson disease; brain stem; cerebral cortex; neurites; therapeutics; Show all 6 Subjects
Abstract:
... Parkinson's disease is the second most prevalent neurodegenerative disease. The loss of dopaminergic neurons in the substantia nigra is one of the pathological hallmarks of PD. PD also belongs to the class of neurodegenerative disease known as ‘Synucleinopathies’ as α-synuclein is responsible for disease development. The presence of aggregated α-synuclein associated with other proteins found in th ...
neurotoxicity, etc ; Alzheimer disease; animal models; brain; etiology; physical chemistry; Show all 6 Subjects
Abstract:
... Alzheimer's and Parkinson's diseases are neurodegenerative conditions affecting over 50 million people worldwide. Since these disorders are still largely intractable pharmacologically, discovering effective treatments is of great urgency and importance. These conditions are characteristically associated with the aberrant deposition of proteinaceous aggregates in the brain, and with the formation o ...
neurotoxicity, etc ; biomineralization; carcinogenicity; genotoxicity; heavy metals; remediation; soil pollution; China; Show all 8 Subjects
Abstract:
... Smelting activities pose serious environmental problems due to the local and regional heavy metal pollution in soils they cause. It is therefore important to understand the pollution situation and its source in the contaminated soils. In this paper, data on heavy metal pollution in soils resulting from Pb/Zn smelting (published in the last 10 years) in China was summarized. The heavy metal polluti ...
neurotoxicity, etc ; brain; endocytosis; lysosomes; neurons; neuroplasticity; nutrient uptake; plasma membrane; Show all 8 Subjects
Abstract:
... Endocytosis is an essential cellular process required for multiple physiological functions, including communication with the extracellular environment, nutrient uptake, and signaling by the cell surface receptors. In a broad sense, endocytosis is accomplished through either constitutive or ligand‐induced invagination of the plasma membrane, which results in the formation of the plasma membrane‐ret ...
neurotoxicity, etc ; bariatric surgery; kynurenine; lipids; metabolome; nutrition; obesity; taste; tryptophan; Show all 9 Subjects
Abstract:
... Diet-induced obesity (DIO) reduces the orosensory perception of lipids in rodents and in some humans. Although bariatric surgery partially corrects this alteration, underlying mechanisms remain poorly understood. To explore whether metabolic changes might explain this fat taste disturbance, plasma metabolome analyses, two-bottle choice tests and fungiform papillae (Fun) counting were performed in ...
neurotoxicity, etc ; Danio rerio; bifenthrin; bioaccumulation; carbon nanotubes; enantiomers; enantioselectivity; immunity; Show all 8 Subjects
Abstract:
... The effects of different multi-walled carbon nanotubes on the enantioselective bioaccumulation and toxicity of the chiral pesticide bifenthrin to zebrafish were investigated in this work. The results showed that MWCNTs and MWCNTs-COOH did not affect the preferential bioaccumulation of 1R-cis-BF in zebrafish following exposure to cis-BF enantiomers for 28 days, but which increased cis-BF accumulati ...
neurotoxicity, etc ; apoptosis; autophagy; dose response; ecotoxicology; heavy metals; memory disorders; neurogenesis; Show all 8 Subjects
Abstract:
... Cadmium (Cd), a ubiquitous toxic heavy metal, with the intractable trait of low degradation, can induce multiple organ damage. Whereas, far less is known about its neurotoxicity and the specific mechanism in the chronic low Cd exposure. To investigate the chronic neurotoxicity of Cd²⁺, we traced its effects for up to 30 months in mice which were exposed to Cd²⁺ by drinking the mimicking Cd‐pollute ...
neurotoxicity, etc ; Western blotting; anesthesia; breathing; functional foods; memory; neonates; resveratrol; sevoflurane; Show all 9 Subjects
Abstract:
... Inhalation anesthetics have been shown to cause neurodevelopmental disorders and neurotoxic effects. In this study, we aimed to investigate the effect of resveratrol on the possible neurotoxic effect of sevoflurane and the brain-derived neurotrophic factor (BDNF) pathway in newborn rats. The animals were divided into four groups: control, sevoflurane, sevoflurane+resveratrol 25 mg/kg, and sevoflur ...
neurotoxicity, etc ; astrocytes; corn oil; dibutyl phthalate; environment; hypothalamus; neurodevelopment; protein synthesis; Show all 8 Subjects
Abstract:
... It has been demonstrated that activated astrocytes in the hypothalamus could disrupt GnRH secretion in offspring after maternal di-n-butyl phthalate (DBP) exposure, indicating that the effect of DBP on astrocyte activation and crosstalk between astrocytes and neurons is still worthy of further investigation. In this study, pregnant mice were intragastrically administered DBP dissolved in corn oil ...
neurotoxicity, etc ; childhood; confidence interval; environment; metabolites; neurodevelopment; pregnancy; prenatal development; pyrethrins; Show all 9 Subjects
Abstract:
... Pyrethroid insecticides are commonly used in residential settings, and their use has increased rapidly. Although research has been scarce, they have been reported to be associated with impaired neurodevelopment. Moreover, susceptible exposure windows and the long-term effects of pyrethroids have not been investigated. We examined the association between pyrethroid exposure and attention-deficit/hy ...