PubAg

Main content area

You searched for: Subject "neurotoxicity" Remove constraint Subject: "neurotoxicity"
Start Over

Search

2,797  Search Results

« Previous | 1 - 20 of 2,797 |
Number of results to display per page

Search Results

1. The why and how of micro(nano)plastic research

Author:
Oliveira, M.; Almeida, M.
Source:
Trends in analytical chemistry 2019 v.114 pp. 196-201
ISSN:
0165-9936
Subject:
neurotoxicity,   etc   ; energy; metabolism; nanoplastics; pollution; risk;     Show all 6 Subjects
Abstract:
... The presence of small plastic particles in the environment, reported for the first time in the 1970's, has only recently been recognized as a global issue. Although environmental awareness continues to grow, so does its consumption and associated risks. The number of studies reporting the presence of microplastics, has grown exponentially as did the concern over plastic degradation into smaller pa ...
DOI:
10.1016/j.trac.2019.02.023

2. An unusual case of gross myoglobinuria in a child following Russell's viper (Daboia russelii) envenomation

Author:
Dissanayake, P.V.; Muthukumarana, T.G.W.; Aslam, W.A.M.; Chaminda, S.A.A.; Munasinghe, T.S.; Kularatne, S.A.M.
Source:
Toxicon 2019 v.157 pp. 77-79
ISSN:
0041-0101
Subject:
neurotoxicity,   etc   ; Daboia russelii; children; nephrotoxicity; snakes;     Show all 5 Subjects
Abstract:
... Overt myoglobinuria associated with myotoxicity is a classic feature of sea snake envenomation. Russell's viper bites usually result in coagulopathy, neurotoxicity and nephrotoxicity but rarely myotoxicity has been reported, especially in the Sri Lankan variety (Daboia russelii). All those studies have demonstrated mild degree myotoxicity with microscopic level myoglobinuria. We report what is pro ...
DOI:
10.1016/j.toxicon.2018.11.299

3. Regulation of neuronal microtubule dynamics by tau: Implications for tauopathies

Author:
Venkatramani, Anuradha; Panda, Dulal
Source:
International journal of biological macromolecules 2019 v.133 pp. 473-483
ISSN:
0141-8130
Subject:
neurotoxicity,   etc   ; Alzheimer disease; Parkinson disease; axons; microtubules; proteins; synaptic vesicles;     Show all 7 Subjects
Abstract:
... In specialized cell types such as neurons, microtubules maintain the integrity of axons by forming stable bundles and facilitate the transport of synaptic vesicles. The cells regulate the stability and dynamics of microtubules using a diverse array of mechanisms. One of the mechanisms involves the interaction of microtubules with its associated proteins. Microtubule-associated proteins (MAPs) may ...
DOI:
10.1016/j.ijbiomac.2019.04.120

4. Blood lead levels and cognitive functioning: A meta-analysis

Author:
Vlasak, Thomas; Jordakieva, Galateja; Gnambs, Timo; Augner, Christoph; Crevenna, Richard; Winker, Robert; Barth, Alfred
Source:
The Science of the total environment 2019 v.668 pp. 678-684
ISSN:
0048-9697
Subject:
neurotoxicity,   etc   ; adults; blood; cognition; lead; meta-analysis; models; statistical analysis;     Show all 8 Subjects
Abstract:
... The neurotoxicity of lead is well-known and even low exposure levels potentially impact neurocognitive abilities. This metaanalysis aimed to investigate associations between neurocognitive performance and lead exposure in adults and further assess potential effect thresholds.Articles indexed in Medline published until January 2017 reporting associations between lead exposure, blood lead, cognitive ...
DOI:
10.1016/j.scitotenv.2019.03.052

5. Membrane-mimetic systems for biophysical studies of the amyloid-β peptide

Author:
Österlund, Nicklas; Luo, Jinghui; Wärmländer, Sebastian K.T.S.; Gräslund, Astrid
Source:
Biochimica et biophysica acta 2019 v.1867 no.5 pp. 492-501
ISSN:
1570-9639
Subject:
neurotoxicity,   etc   ; Alzheimer disease; amyloid; biophysics; cell membranes; lipids; models;     Show all 7 Subjects
Abstract:
... The interplay between the amyloid-β (Aβ) peptide and cellular membranes have been proposed as an important mechanism for toxicity in Alzheimer's disease (AD). Membrane environments appear to influence Aβ aggregation and may stabilize intermediate Aβ oligomeric states that are considered to be neurotoxic. One important role for molecular biophysics within the field of Aβ studies is to characterize ...
DOI:
10.1016/j.bbapap.2018.11.005

6. An AIE-active theranostic probe for light-up detection of Aβ aggregates and protection of neuronal cells

Author:
YangY. Yang and S. Li contributed equally to this work., Yaqi; Li, Shiwu; Zhang, Qin; Kuang, Ying; Qin, Anjun; Gao, Meng; Li, Feng; Tang, Ben Zhong
Source:
Journal of materials chemistry B 2019 v.7 no.15 pp. 2434-2441
ISSN:
2050-7518
Subject:
neurotoxicity,   etc   ; Alzheimer disease; chemistry; fluorescent dyes; image analysis; neurons;     Show all 6 Subjects
Abstract:
... Alzheimer's disease (AD) is one of the most serious health threats in our aging society. The major pathological feature of AD is excessive extracellular aggregation of β-amyloid (Aβ) protein in the form of Aβ fibrils or plaques. The simultaneous detection of Aβ fibrils and inhibition of their neurotoxicity is highly desirable for study of Alzheimer's disease. Although various fluorophores have bee ...
DOI:
10.1039/c9tb00121b

7. Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 1. On medical care and treatment of injuries from nerve agents

Author:
Timperley, Christopher M.; Forman, Jonathan E.; Abdollahi, Mohammad; Al-Amri, Abdullah Saeed; Baulig, Augustin; Benachour, Djafer; Borrett, Veronica; Cariño, Flerida A.; Geist, Michael; Gonzalez, David; Kane, William; Kovarik, Zrinka; Martínez-Álvarez, Roberto; Mourão, Nicia Maria Fusaro; Neffe, Slawomir; Raza, Syed K.; Rubaylo, Valentin; Suárez, Alejandra Graciela; Takeuchi, Koji; Tang, Cheng; Trifirò, Ferruccio; van Straten, Francois Mauritz; Vanninen, Paula S.; Vučinić, Slavica; Zaitsev, Volodymyr; Zafar-Uz-Zaman, Muhammad; Zina, Mongia Saïd; Holen, Stian
Source:
Toxicology 2019 v.415 pp. 56-69
ISSN:
0300-483X
Subject:
neurotoxicity,   etc   ; health care workers; humans; nerve agents; skin diseases; therapeutics;     Show all 6 Subjects
Abstract:
... The Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) has provided advice on assistance and protection in relation to the Chemical Weapons Convention. In this, the first of several papers describing the SAB’s work on this topic, we describe advice given in response to questions from the OPCW Director-General in 2013 and 2014 on the status of availab ...
DOI:
10.1016/j.tox.2019.01.004

8. Deciphering the mode of action of pollutants impairing the fish larvae escape response with the vibrational startle response assay

Author:
Faria, Melissa; Bedrossiantz, Juliette; Prats, Eva; Rovira Garcia, Xavier; Gómez-Canela, Cristian; Piña, Benjamin; Raldúa, Demetrio
Source:
The Science of the total environment 2019 v.672 pp. 121-128
ISSN:
0048-9697
Subject:
neurotoxicity,   etc   ; antagonists; escape behavior; fish larvae; habituation; imidacloprid; mechanism of action; muscarine receptors; neurotransmitters; pollutants; scopolamine;     Show all 11 Subjects
Abstract:
... The escape response evoked by vibrational stimuli and its habituation, essential behaviors for fish larvae survival, can be altered by neurotoxic environmental pollutants commonly found in our aquatic ecosystems.In this study we have analyzed the suitability of the Vibrational Startle Response Assay (VSRA) to obtain mechanistic information about the mode of action (MoA) of the chemicals impairing ...
DOI:
10.1016/j.scitotenv.2019.03.469

9. DEHP triggers cerebral mitochondrial dysfunction and oxidative stress in quail (Coturnix japonica) via modulating mitochondrial dynamics and biogenesis and activating Nrf2-mediated defense response

Author:
Luo, Yu; Li, Xue-Nan; Zhao, Yi; Du, Zheng-Hai; Li, Jin-Long
Source:
Chemosphere 2019 v.224 pp. 626-633
ISSN:
0045-6535
Subject:
neurotoxicity,   etc   ; Coturnix japonica; biogenesis; cerebrum; females; food chain; histology; humans; mitochondria; oxidative stress; phthalates; quails; wildlife;     Show all 13 Subjects
Abstract:
... Di-(2-ethylhexyl) phthalate (DEHP) in the environment and food chain may impact cerebrum development and neurobehavioral in humans and wildlife. However, it is unclear that DEHP exposure caused cerebral toxicity. This experiment used gavage to expose female quail to 0, 250, 500, and 1000 mg/kg BW/day for 45 days to assess the potential neurotoxicity of DEHP to the cerebrum. It can be observed that ...
DOI:
10.1016/j.chemosphere.2019.02.142

10. Neurotoxic assessment of Microcystin-LR, cylindrospermopsin and their combination on the human neuroblastoma SH-SY5Y cell line

Author:
Hinojosa, M.G.; Prieto, A.I.; Gutiérrez-Praena, D.; Moreno, F.J.; Cameán, A.M.; Jos, A.
Source:
Chemosphere 2019 v.224 pp. 751-764
ISSN:
0045-6535
Subject:
neurotoxicity,   etc   ; Cyanobacteria; acetylcholinesterase; apoptosis; cell lines; cylindrospermopsin; cytotoxicity; cytotoxins; glutathione; humans; microcystin-LR; oxidative stress;     Show all 12 Subjects
Abstract:
... Microcystin-LR (MC-LR) and Cylindrospermopsin (CYN) are produced by cyanobacteria. Although being considered as a hepatotoxin and a cytotoxin, respectively, different studies have revealed neurotoxic properties for both of them. The aim of the present work was to study their cytotoxic effects, alone and in combination, in the SH-SY5Y cell line. In addition, toxicity mechanisms such as oxidative st ...
DOI:
10.1016/j.chemosphere.2019.02.173

11. Gestational exposure to acrylamide inhibits mouse placental development in vivo

Author:
Yu, Dainan; Xie, Xingxing; Qiao, Bo; Ge, Wenjing; Gong, Lixin; Luo, Dan; Zhang, Dalei; Li, Yuezhen; Yang, Bei; Kuang, Haibin
Source:
Journal of hazardous materials 2019 v.367 pp. 160-170
ISSN:
0304-3894
Subject:
neurotoxicity,   etc   ; acrylamides; apoptosis; atrophy; carcinogens; foods; gene expression; genes; heat treatment; messenger RNA; mice; placenta; proteins;     Show all 13 Subjects
Abstract:
... Acrylamide, a carcinogen and neurotoxic substance, recently has been discovered in various heat-treated carbohydrate-rich foods. The aim of this study was to investigate the effects of acrylamide exposure on placental development. Pregnant mice received acrylamide by gavage at dosages of 0, 10, and 50 mg/kg/day from gestational days (GD) 3 until GD 8 or GD 13. The results showed that acrylamide fe ...
DOI:
10.1016/j.jhazmat.2018.12.061

12. No Effect of Polystyrene Microplastics on Foraging Activity and Survival in a Post-larvae Coral-Reef Fish, Acanthurus triostegus

Author:
Jacob, Hugo; Gilson, Arthur; Lanctôt, Chantal; Besson, Marc; Metian, Marc; Lecchini, David
Source:
Bulletin of environmental contamination and toxicology 2019 v.102 no.4 pp. 457-461
ISSN:
0007-4861
Subject:
neurotoxicity,   etc   ; Acanthurus; environmental impact; fish; fish communities; foraging; marine environment; microplastics; polystyrenes; postlarvae; predation; predators;     Show all 12 Subjects
Abstract:
... Microplastics (MP) are ubiquitous in the marine environment and have been shown to alter the behaviour of some species due to potential neurotoxic effect. However, very little is known on the effect of this stressor on behavioural responses of early and more vulnerable life stages. This study explores the effects of polystyrene MP (90 µm diameter) on the foraging activity of newly settled surgeonf ...
DOI:
10.1007/s00128-019-02587-0

13. Adverse effects of hexaclorobenzene exposure in children

Author:
Casadó, Lina; Pedro Arrebola, Juan; Fontalba, Andrés; Muñoz, Araceli
Source:
Environmental research 2019
ISSN:
0013-9351
Subject:
neurotoxicity,   etc   ; adverse effects; byproducts; children; databases; health effects assessments; hepatotoxicity; hexachlorobenzene; immunotoxicity; industry; nephrotoxicity; pesticide mixtures;     Show all 12 Subjects
Abstract:
... Hexachlorobenzene (HCB: C₆Cl₆) is a persistent, bioaccumulative chemical formerly used worldwide in pesticide mixtures but also produced as a by-product in the chemical and metallurgical industry. Despite current international restrictions in the use and production of HCB, the majority of the general population still shows detectable levels of HCB, which raises concerns on the potential health imp ...
DOI:
10.1016/j.envres.2019.03.059

14. Sevoflurane enhanced the clearance of Aβ1-40 in hippocampus under surgery via up-regulating AQP-4 expression in astrocyte

Author:
Gao, Xuan; Ming, Jiang; Liu, Shiwen; Lai, Bin; Fang, Fang; Cang, Jing
Source:
Life sciences 2019 v.221 pp. 143-151
ISSN:
0024-3205
Subject:
neurotoxicity,   etc   ; T-lymphocytes; astrocytes; cognition; hippocampus; humans; sedation; sevoflurane; sleep; surgery;     Show all 10 Subjects
Abstract:
... The neurotoxicity of anesthetics on developing brain has been a focused issue for years. However, controversy exists between human and animal studies and surgery may be a potential reason for this. The discovery of glymphatic system, a pathway eliminating soluble substance from central nervous system (CNS), together with recent evidence that surgery-induced Aβ increase contributes to cognition dys ...
DOI:
10.1016/j.lfs.2019.02.024

15. Characterizing the structural and thermodynamic properties of Aβ42 and Aβ40

Author:
Lin, Yuxi; Im, Haeri; Diem, Le Thi; Ham, Sihyun
Source:
Biochemical and biophysical research communications 2019 v.510 no.3 pp. 442-448
ISSN:
0006-291X
Subject:
neurotoxicity,   etc   ; Alzheimer disease; Gibbs free energy; amyloid; humans; hydrophobicity; moieties; molecular dynamics; simulation models; water;     Show all 10 Subjects
Abstract:
... The self-assembly of amyloid-beta (Aβ) proteins in aqueous extracellular environments is implicated in Alzheimer's disease. Among several alloforms of Aβ proteins differing in sequence length, the 42- and 40-residue forms (Aβ42 and Aβ40) are the most abundant ones in the human body. Although the only difference is the additional I41A42 residues in the C-terminus, Aβ42 exhibits more aggregation ten ...
DOI:
10.1016/j.bbrc.2019.01.124

16. α-Synuclein misfolding and aggregation: Implications in Parkinson’s disease pathogenesis

Author:
Mehra, Surabhi; Sahay, Shruti; Maji, Samir K.
Source:
Biochimica et biophysica acta 2019
ISSN:
1570-9639
Subject:
neurotoxicity,   etc   ; Lewy bodies; Parkinson disease; cell death; mutants; neurites; pathogenesis; pathogens; phenotype; plasticity; point mutation; therapeutics;     Show all 12 Subjects
Abstract:
... α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical properties owing to its pathophysiological role in Parkinson’s disease (PD). Lewy bodies and Lewy neurites are the pathological hallmarks of PD and contain α-Syn aggregates as their major component. It was therefore hypothesized that α-Syn aggregation is actively associated with PD pathogenesis. The central role of ...
DOI:
10.1016/j.bbapap.2019.03.001

17. Neurotoxic envenomation by the South African coral snake (Aspidelaps lubricus): A case report

Author:
Barton, David J.; Shao, Shirley; Marino, Ryan T.; Reichmeider, Alex; Yanta, Joseph H.; Pizon, Anthony F.
Source:
Toxicon 2019 v.159 pp. 38-40
ISSN:
0041-0101
Subject:
neurotoxicity,   etc   ; Elapidae; antivenoms; case studies; eggs; females; humans; muscles; paralysis; physicians; snakes; vomiting;     Show all 12 Subjects
Abstract:
... The South African coral snake (Aspidelaps lubricus, Elapidae) has not previously been reported to cause any neurotoxic envenomations in humans. We recently treated a 44-year-old man who was bitten twice, once in each hand, by a captive South African coral snake (Aspidelaps lubricus) while feeding the female snake who had recently laid eggs. Approximately one hour after receiving the bite, he devel ...
DOI:
10.1016/j.toxicon.2019.01.001

18. Population pharmacokinetic modelling of total and unbound flucloxacillin in non-critically ill patients to devise a rational continuous dosing regimen

Author:
Wilkes, Sarah; van Berlo, Inge; ten Oever, Jaap; Jansman, Frank; ter Heine, Rob
Source:
International journal of antimicrobial agents 2019 v.53 no.3 pp. 310-317
ISSN:
0924-8579
Subject:
neurotoxicity,   etc   ; Monte Carlo method; anti-infective agents; blood serum; intravenous injection; models; patients; pharmacokinetics; serum albumin;     Show all 9 Subjects
Abstract:
... This study's objective was to describe the population pharmacokinetics of total and unbound flucloxacillin in non-critically ill patients, and to devise a rational continuous dosing regimen for this population.Total and unbound flucloxacillin pharmacokinetics in 30 non-critically ill patients receiving intravenous flucloxacillin were analysed using non-linear mixed-effects modelling. Monte Carlo s ...
DOI:
10.1016/j.ijantimicag.2018.11.018

19. Formation of large oligomers of DOPAL-modified α-synuclein is modulated by the oxidation of methionine residues located at C-terminal domain

Author:
Coelho-Cerqueira, Eduardo; de Araújo Correia Campos, Camila; Follmer, Cristian
Source:
Biochemical and biophysical research communications 2019 v.509 no.2 pp. 367-372
ISSN:
0006-291X
Subject:
neurotoxicity,   etc   ; Parkinson disease; aldehydes; amino acid sequences; dopamine; hydrogen peroxide; hydrophobicity; methionine; mutants; neurons; oxidation;     Show all 11 Subjects
Abstract:
... The formation of neurotoxic oligomers of the presynaptic protein α-Synuclein (aSyn) is suggested to be associated with Parkinson's disease neurodegeneration. In this respect, it was demonstrated that the aldehyde 3,4-dihydroxyphenylacetaldehyde (DOPAL), a product from the enzymatic oxidation of dopamine, is capable of stabilizing potentially toxic aSyn oligomers via formation of covalent adducts w ...
DOI:
10.1016/j.bbrc.2018.12.128

20. Detection of amyloid β oligomers toward early diagnosis of Alzheimer's disease

Author:
Hwang, Soyoon Sarah; Chan, Hon; Sorci, Mirco; Van Deventer, James; Wittrup, Dane; Belfort, Georges; Walt, David
Source:
Analytical biochemistry 2019 v.566 pp. 40-45
ISSN:
0003-2697
Subject:
neurotoxicity,   etc   ; Alzheimer disease; amyloid; analytical methods; brain; detection limit; early diagnosis; monoclonal antibodies; quartz crystal microbalance;     Show all 9 Subjects
Abstract:
... Amyloid β (Aβ) peptide accumulation in the brain is considered to be one of the hallmarks of Alzheimer's disease. Here, we compare two analytical techniques for detecting neurotoxic Aβ1-42 oligomers - Quartz Crystal Microbalance with Dissipation (QCM-D) and Single Molecule Array (Simoa). Both detection methods exploit a feature of the monoclonal antibody bapineuzumab, which targets N-terminal resi ...
DOI:
10.1016/j.ab.2018.09.011